TY - JOUR. T1 - Peripheral location and infiltrative margin predict invasive features of papillary thyroid microcarcinoma. AU - Lee, Woo Kyung. AU - Lee, Jandee. AU - Kim, Hyunji. AU - Lee, Seul Gi. AU - Choi, Sun Hyung. AU - Jeong, Seonhyang. AU - Kwon, Hyeong Ju. AU - Jung, Sang Geun. AU - Jo, Young Suk. PY - 2019. Y1 - 2019. N2 - Objective: Tumor location in papillary thyroid microcarcinoma (PTMC) might determine tumor outgrowth from the thyroid gland. However, the clinical implications of tumor location and minimal extrathyroid extension (mETE) have not been well elucidated. We aimed to investigate the relationship between tumor location and mETE to predict the aggressiveness of PTMC. Methods: A total of 858 patients with PTMC were grouped according to tumor location on ultrasonography: central (cPTMC) and peripheral PTMC (pPTMC). PTMC without mETE (PTMC-mETE(-)) was divided further according to margin shape: encapsulated (E-) or infiltrative (I-). To understand the molecular biologic ...

TY - JOUR. T1 - Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma. AU - Akaishi, Junko. AU - Sugino, Kiminori. AU - Kameyama, Kaori. AU - Masaki, Chie. AU - Matsuzu, Kenichi. AU - Suzuki, Akifumi. AU - Uruno, Takashi. AU - Ohkuwa, Keiko. AU - Shibuya, Hiroshi. AU - Kitagawa, Wataru. AU - Nagahama, Mitsuji. AU - Shimizu, Kazuo. AU - Ito, Koichi. PY - 2015/7/5. Y1 - 2015/7/5. N2 - Background: Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. Materials and methods: Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Twenty-two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were ,45 years old. We compared clinicopathologic characteristics and outcomes between patients with DSV and those with classical PTC ,45 years old. Univariate analysis by the Kaplan-Meier method in ...

TY - JOUR. T1 - Cytologic features of infarcted thyroid papillary carcinoma induced by fine needle aspiration. AU - Jang, Se Min. AU - Jun, Young Jin. AU - Na, Woong. AU - Jang, Ki Seok. AU - Paik, Seung Sam. PY - 2010/1/1. Y1 - 2010/1/1. KW - Aspiration biopsy, fine-needle. KW - Carcinoma, papillary. KW - Infarction. KW - Thyroid neoplasms. UR - http://www.scopus.com/inward/record.url?scp=78650508591&partnerID=8YFLogxK. M3 - Letter. C2 - 21053614. AN - SCOPUS:78650508591. VL - 54. SP - 1082. EP - 1083. JO - Acta Cytologica. JF - Acta Cytologica. SN - 0001-5547. IS - 5. ER - ...

TY - JOUR. T1 - Intracystic papillary carcinoma. T2 - A review of 917 cases. AU - Grabowski, Julia. AU - Salzstein, Sidney L.. AU - Sadler, Georgia Robins. AU - Blair, Sarah. PY - 2008/9/1. Y1 - 2008/9/1. N2 - BACKGROUND. Intracystic papillary carcinoma (IPC) is an uncommon breast neoplasm. To the authors knowledge there are limited data regarding its epidemiology and only small studies focusing on outcomes. By using a large, population-based database, this study aimed to identify specific characteristics of patients with IPC, investigate its natural history, and determine its long-term prognosis. METHODS. The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988 through 2005. The data were analyzed with regard to patient sex, age at presentation, tumor stage, and overall survival. Cumulative relative actuarial survival was determined using a Berkson-Gage life table method. The CCR classifies IPC as either in situ (CIS) or invasive, as determined by the ...

Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as conditional heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. RAR and RXR ligands are known to play role in reprogramming several tumour cells, and thus the development of appropriate ligands with reduced teratogenic and other side effects are still highly required. In this study, we have investigated expression pattern of retinoid receptor subtypes (RARalpha, RARbeta, RARgamma) and retinoid X nuclear receptor subtypes (RXRalpha, RXRbeta, RXRgamma) in three different human organ malignancies, i) thyroid papillary carcinoma, ii) breast cancer, and iii) renal carcinoma.. ...

Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to diagnose due to its rarity and limited data regarding its clinical behavior. We attempted to assess the degree of stromal invasion using magnetic resonance imaging (MRI) and evaluate possible treatments for this lesion in view of its clinical behavior. We analyzed 28 cases of PSCC diagnosed on the colposcopic selective biopsies. We studied the rate of accuracy of diagnoses of the colposcopic selective biopsies compared with the final diagnoses, and compared the rate of stromal invasion between the MRI and pathological findings while focusing on surgical methods and the clinical prognosis. Of the 28 patients, only 12 exhibited true PSCC. The other 16 patients were ultimately diagnosed with SCC or adenosquamous carcinoma based on the finding of the surgical specimens and exhibited relatively poor prognoses. Among the 12 true PSCC cases, the rate of diagnostic accuracy of stromal invasion (with or without) was only 58% (7/12) on

It remains controversial whether patients with papillary thyroid microcarcinoma (PTMC) benefit from total thyroidectomy (TT) or thyroid lobectomy (TL). We aimed to investigate the impact of extent of surgery on the prognosis of patients with unilateral PTMC. Patients were obtained from the Surveillance, Epidemiology, and End Results database from 2004 to 2015. Cancer-specific survival (CSS) and overall survival (OS) were evaluated by Cox regression and Kaplan-Meier curves with propensity score matching. Of 31167 PTMC patients enrolled, 22.2% and 77.8% of which underwent TL and TT, respectively. Patients with TT were more likely to be younger, females, present tumors of multifocality, extrathyroidal extension, cervical lymph node metastasis (CLNM), distant metastasis, and receive radioactive iodine (RAI) compared with those receiving TL. The multivariate Cox regression model showed that TT was not associated with an improved CSS and OS compared with TL with hazard ratio (HR) and 95% confidence interval

What is the best surgical treatment for papillary thyroid microcarcinoma (PTMC)? Background: Surgeons have debated whether to perform a total or

Papillary carcinoma of the breast is an extremely rare variety of carcinoma breast with a mere incidence of only 0.5% of all recently diagnosed cases of breast cancer. We present a case of 63 years old postmenopausal female who came to the surgical outpatient department with complaints of a slowly increasing mass in the left breast of 1-month duration which was painless. A Left-sided modified radical mastectomy was performed with an absolutely normal post-operative period. The final histopathology report was suggestive of invasive papillary carcinoma. We report this case as it is rarely diagnosed. KEYWORDS: Invasive papillary carcinoma, modified radical mastectomy, carcinoma breast.. ...

TY - JOUR. T1 - Is invasive micropapillary serous carcinoma a low-grade carcinoma?. AU - Ohishi, Yoshihiro. AU - Imamura, Hiroko. AU - Aman, Murasaki. AU - Shida, Kaai. AU - Kaku, Tsunehisa. AU - Kato, Kiyoko. AU - Oda, Yoshinao. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Invasive micropapillary serous carcinoma has been proposed as a synonym for low-grade serous carcinoma by some expert pathologists. In contrast, Singer and colleagues reported that some serous carcinomas with conspicuous invasive micropapillary pattern (SC-IMPs) can show high-grade nuclear atypia. However, the molecular features of such tumors have not been well documented. The aim of this study was to demonstrate and emphasize the fact that high-grade serous carcinoma confirmed by immunohistochemistry and molecular analysis can show conspicuous invasive micropapillary pattern. We selected 24 SC-IMPs and investigated: (1) their morphologic features; (2) the immunostaining pattern of p53 protein; and (3) KRAS/BRAF/TP53 gene ...

history of IgG monoclonal gamopathy. An ultrasound of the thyroid showed a 10 mm diameter nodule to the right and a 12 mm diameter nodule ... and the prognosis is excellent (in the case the tumor is papillary carcinoma- the most common thyroid malignancy). To conclude- .... ...

RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).

Extrathyroidal extension was more frequent in DSV than in TCV and cPTC patients (p < 0.05); moreover, only DSV tumors had a higher rate of recurrent/persistent disease when compared to cPTC treated with the same protocol (total thyroidectomy followed by (131)I treatment) (p < 0.01). After initial treatment, 54.2% of TCV and 20.4% of DSV patients were classified at low risk, while at ongoing risk stratification, the excellent response (low risk) was higher for both TCV (77.8%) and DSV (50.0%) patients relative to initial stratification (both p < 0.01). Using ongoing risk classification, positive predictive value (PPV) for persistent/recurrent disease was higher relative to initial risk stratification for both TCV (PPV = 93.8 vs. 39.4%) and DSV (PPV = 63.0 vs. 34.9%), p < 0.05 for both. CONCLUSIONS ...

papillary cancer - MedHelps papillary cancer Center for Information, Symptoms, Resources, Treatments and Tools for papillary cancer. Find papillary cancer information, treatments for papillary cancer and papillary cancer symptoms.

But de l étude : le microcarcinome thyroïdien révélé par des adénopathies cervicales est fréquent et il s agit dans la majorité des cas du type papillaire

Intracystic papillary carcinoma of the breast associated with areas of infiltration, is a rare, constituting less than 1% of breast cancers. These are tumors whose initial radiological study shows lesions with low suspicion of malignancy in a high proportion of cases. We present two cases of intracystic papillary carcinoma, associated with infiltration diagnosed at the Breast Unit of Hospital Infanta Cristina In both cases the reason for consultation was the palpation of a nodule and initial radiographic approach showed lesions with low suspicion of malignancy ...

Patient: Thyroid Cancer > Papillary Carcinoma > Tall Cell Patient Info: Currently in active treatment (initial surgery, receiving chemo rounds/radiation), Diagnosed: over 10 years ago, Female, Age: 66, Stage IV

The thyroid is the organ that has the greatest risk of malignant tumors among the endocrine tumors. The papillary carcinoma occupies 80% of the entire thyroid tumors. Immunohistochemical staining of galectin-3 has usually been used in differentiating papillary carcinoma and follicular carcinoma. The p53 gene of the cell cycle is a tumor suppressor gene acting in on the control points. The cyclin D1 genes in the cell cycle, involved in the implementation of G1 and S phase, plays an important role in the progression of thyroid tumors. This research compares and analyzes correlation between papillary carcinoma, follicular carcinoma, p53, cyclin D1 and galectin-3 gene expression patterns. In a total of 30 cases from papillary carcinoma, 21 cases from p53 (70%), 27 cases in galectin-3 (90%), and 26 cases in cyclin D1 (86.7%) showed positive rate. The galectin-3 staining investigated, showed a significant difference between a papillary carcinoma and a follicular carcinoma. Follicular carcinoma from 15 ...

TY - JOUR. T1 - Papillary carcinoma of the thyroid gland. AU - Baker, R. Robinson. AU - Hyland, J.. PY - 1985. Y1 - 1985. N2 - The results of this analysis have demonstrated that papillary carcinoma of the thyroid gland rarely causes the death of the patient. Bilateral subtotal lobectomies, partial lobectomies and probably total lobectomy combined with contralateral partial lobectomy should not be performed in the treatment of this disease. The incidence of local recurrence is higher after these procedures, and any subsequent operative procedure is complicated by scarring secondary to the initial procedure. Total lobectomy is the procedure of choice for patients with disease confined to one lobe on palpation. Total thyroidectomy should only be performed for palpable disease in both lobes. Excision of a grossly normal contralateral lobe solely to obtain microscopic tumor which rarely becomes clinically apparent is not worth the inherent risk of bilateral recurrent palsy of the nerve or permanent ...

JIM HSU, JAE Y. RO. The 2016 WHO classification of tumors of the urothelial tract recently revised the classification of invasive urothelial carcinoma to include nested, microcystic, micropapillary, plasmacytoid, sarcomatoid, giant cell, and poorly differentiated variants, among others. In particular, invasive micropapillary carcinoma (IMPC) is now recognized as a distinct entity with aggressive f

In 2016, Saleh [59] from Egypt, performed heterotopic autotransplantation of fresh thyroid tissue for 20 patients who underwent TT (13 with simple MNG, 4 with Graves disease and 3 with toxic nodular goiter). Intraoperatively, 10-15 g of the healthiest looking non-nodular part of the excised gland was minced into 1-2 mm slices after stripping of its fibrous capsule. The tissue was then made into an emulsion of 20 mL lactated Ringers solution and injected through the rectus femoris muscle in 6-8 different directions using a specially designed wide bore needle. The final postoperative pathology reported a follicular variant of thyroid papillary carcinoma in 2 patients in whom preoperative pathology missed their diagnosis. The 2 patients had their graft excised and were excluded from the study. Follow-up of 18 patients was done to report the survival and function of the heterotopic transplanted thyroid tissue through 99mTc uptake at 2-month postoperatively and thyroid function tests (FT3, FT4, and ...

TY - JOUR. T1 - Asymptomatic Solid Pseudopapillary Neoplasm of the Pancreas. AU - Gleeson, Ferga C.. AU - Smyrk, Thomas C.. AU - Chari, Suresh T.. PY - 2008/1/1. Y1 - 2008/1/1. UR - http://www.scopus.com/inward/record.url?scp=37349075371&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=37349075371&partnerID=8YFLogxK. U2 - 10.1016/j.cgh.2007.10.014. DO - 10.1016/j.cgh.2007.10.014. M3 - Article. C2 - 18166468. AN - SCOPUS:37349075371. VL - 6. SP - A22. JO - Clinical Gastroenterology and Hepatology. JF - Clinical Gastroenterology and Hepatology. SN - 1542-3565. IS - 1. ER - ...

Ms. Aida Antonio was 29 years old when I did a thyroidectomy on her thyroid papillary carcinoma. She is now 53 years old with no clinical evidence of recurrence. We both thank God for this long 24 years of remission.

The incidence of thyroid cancer is increasing globally. This is mainly due to the increase in the detection of small papillary carcinomas, including papillary microcarcinomas (PMC) 1 cm or smaller. It

Has anybody here been diagnosed with Papillary Carcinoma Thyroid Cancer that has affected the surrounding lymph nodes? My 21 y/o cousin was diagnosed and her thyroid along with lymph nodes were removed less than a month ago. The pathology report showed several nodules on the thyroid (2 on the left node 2x1x1 cm in size, and several on the right node with the biggest one being 2.5x2x1 cm). The lymph nodes removed some are tumor compromised, and some have extranodal extension. Shes having a 2nd

Every thyroid case is different, survival depends on many different factors like age, or how long you had cancer before discovery, etc. Im not a doctor. But I am a Thyroid Cancer Survivor x 21 years now. My cancer was Papillary Carcinoma. From all that I have been told and read-- is that you can get thyroid cancer from being exposed to x-rays, especially if you had them when you were a child, it doesnt have to be because of Chernobyl. If you have had your surgery, you are on your road to recovery...for me, only one lobe had cancer, it was removed,the other lobe remained. No chemo was needed. The docs told me that I needed to have suppression therapy, they use Synthroid. They say-- that is because I still have one lobe left and there is a potential for cancer cells, suppressing the lobe will hopefully keep the cancer cells at bay for awhile. The other thing the docs are doing is keeping my TSH level low, ,1. Please keep your chin up, I wish you all the best with your health in the ...

Papillary carcinoma of the breast encompasses a spectrum of histologic subtypes. There are two common types: cystic (noninvasive form) and micropapillary ductal carcinoma (invasive form). Papillary br... more

I dont have an oncologist either, my endocrinologist specializes in treating thyroid cancer patients so I didnt see a need. You can talk to your endo about this, bring all the lab reports from your mamograms, sonograms and biopsy so he has something to look at. Your surgeon may also be very knowledgable about the questions you have, depending on his speciality.. I think if the breast cancer is metastic thyroid cancer they would have told you so, but best to ask to be certain.. Yes, I know what you mean, lucky to catch it early. I didnt know anything was wrong until I felt a swollen lymph node in my neck. Per doctors orders, I waited for a few months for it to go down, then spent another month waiting for the biopsy and found I had papillary. I had a TT and neck disection 2/11 and RAI 4/11. So far no recurrance, but well see. Theyre right when they say lucky, if I had ignored the lump, Id probably be dealing with a larger metastic spread than just a couple of nodes in my neck. The thing ...

Tytu : Simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of papillary carcinoma to the cervical lymph nodes and the coinciding small B-cell lymphocytic lymphoma of the lymph nodes - a case report. ...

Thyroid carcinoma seems to have generated a considerable number of misconceptions. About 20% of these tumors are pure papillary, about 10% pure follicular, about 50% mixed papillary and follicular, and about 5% (range, 2%-10%) are called medullary. However, the pure papillary carcinoma usually has a few follicular elements if enough histologic sections are made, and […]. ...

OYAMA Tetsunari , SUZUKI Takeshi , HARA Futoshi , IINO Yuich , ISHIDA Tsunehiro , SAKAMOTO Atsuhiko , NAKAJIMA Takashi Pathology international 45(1), 45-50, 1995-01 医中誌Web 参考文献21件 被引用文献6件 ...

Treatment Options by Stage. Stage 0 (Papillary Carcinoma and Carcinoma in Situ). Treatment of stage 0 may include the following:. ...

By definition, clinical papillary carcinomas are 1. 60 The example indicates that cross-resistance is increased for hydrophilic drugs of moderate size.

TY - JOUR. T1 - Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival. AU - Holoubek, Simon A.. AU - Yan, Huan. AU - Khokar, Amna H.. AU - Kuchta, Kristine M.. AU - Winchester, David J.. AU - Prinz, Richard A.. AU - Moo-Young, Tricia A.. N1 - Publisher Copyright: © 2019 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/1. Y1 - 2020/1. N2 - Background: This study compares pathologic features and overall survival of classic versus aggressive variants of papillary thyroid microcarcinoma (PMTC). Methods: Patients ≥18 years in the National Cancer Data Base (2004-2015) with the subtypes of classic (cPTMC), tall cell (mTCV), or diffuse sclerosing (mDSV) PTC (≤1 cm) were identified. Overall survival was analyzed by Kaplan-Meier and propensity matched for clinicopathologic and treatment variables. Results: There were 82,056 cPTMC patients, 923 mTCV, and 219 mDSV. Extrathyroidal extension and ...

Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated ...

Solid pseudopapillary tumors are rare, with the majority of described cases originating in the pancreas. To date, there are only 10 documented reports of primary ovarian solid pseudopapillary tumors. Here, we describe the case of a 24-year-old woman who presented with worsening pelvic pain and dysmenorrhea. Workup demonstrated a right ovarian solid mass on ultrasound and an elevated serum LDH, which raised concerns for dysgerminoma due to her relatively young age. Therefore, she was taken to the operating room and underwent laparoscopic right salpingo-oophorectomy. On initial rapid frozen section, her ovarian cyst had a grossly hemorrhagic appearance with multiple hemosiderin deposits noted microscopically, which suggested a benign hemorrhagic cyst. However, the final pathology was reported as solid pseudopapillary tumor based on several defining histologic characteristics. Most importantly, immunostaining was positive for |i|β|/i|-catenin and negative for E-cadherin. This report presents a brief

Although the vast majority of patients with Papillary Thyroid Microcarcinoma (PTMC) have excellent long-term outcomes, some patients experience tumor re

A collision tumor involving a tracheal sarcomatoid carcinoma and a papillary thyroid carcinoma has never been reported in the literature. A 78-year-old female presented with a large neck mass and hoarseness. A fine needle aspiration demonstrated papillary thyroid carcinoma. Imaging revealed a right thyroid mass invading into the tracheal lumen with bulky ipsilateral lymphadenopathy. The patient underwent a total thyroidectomy, tracheal resection, and central and right neck dissections. Pathology demonstrated a tracheal sarcomatoid carcinoma invading the right thyroid, which had multifocal papillary thyroid carcinoma with central and lateral neck metastases. The patient subsequently received adjuvant chemoradiotherapy and radioactive iodine. We present a case of a tracheal sarcomatoid carcinoma colliding with a papillary thyroid cancer. Treatment modalities should address the most aggressive tumor, while being tailored to clinical picture, tumor histology, and patient preferences.

The study objective is to analyze the mutation profile of the tall cell variant (TCV) of papillary thyroid carcinoma (PTC). Materials and methods. The main inclusion criteria according to the WHO classification (2017) was PTC composed of at least 30 % of tall cells. Genetic examination was conducted using the FoundationOne CDx assay (USA) with median depth of coverage of |500x. This study included 5 patients (1 man and 4 women) with a mean age of 52.6 years (range: 48-56 years). The tumor size varied between 0.4 x 0.5 cm and 11.0 x 9.0 cm. All patients have undergone surgical treatment: hemithyroidectomy for patient No. 1 with a small tumor (pT1b); thyroidectomy for patient No. 2 (pT3b); extensive thyroidectomy with the removal of paratracheal tissue for patients No. 3, 4, and 5 (No. 3 - pT3bN0; No. 4 - pT3bN1b; No. 5 - pT3bN1b). Three out of the five patients also had adenomatous goiter. The mean follow-up time was 3.4 to 5.2 years. Results. Tumors in all patients were characterized by low mutational

A comprehensive analysis of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer: Confirmation of linkage to TCO1. About 5% of nonmedullary thyroid cancer is familial. These familial nonmedullary thyroid cancer cases are characterized by an earlier age of onset, more aggressive phenotype, and in some families a high propensity to benign thyroid disease. Little is known about the genes conferring predisposition to nonmedullary thyroid cancer. Three loci have been identified through genetic linkage: MNG1 on 14q32, TCO1 on 19p13.2, and fPTC on 1p21. In addition to these putative genes, a number of loci represent candidate familial nonmedullary thyroid cancer predisposition genes by virtue of their involvement in sporadic disease (TRKA), their role in benign disease (TSHR), and because they underlie syndromes with a risk of nonmedullary thyroid cancer (PTEN). To evaluate the roles of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer, we have ...

TY - JOUR. T1 - Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. AU - Tang, Wendell W.. AU - Stelter, Arwen A.. AU - French, Samuel. AU - Shen, Steven. AU - Qiu, Suimin. AU - Venegas, Rose. AU - Wen, Julie. AU - Wang, Hui Qun. AU - Xie, Jingwu. PY - 2007/5/30. Y1 - 2007/5/30. N2 - Solid pseudopapillary tumor of pancreas (SPT) is a rare neoplasm that occurs most often in young females with the two distinct features, the solid-cystic gross appearance, and the solid-pseudopapillary microscopic pattern. It has been reported that almost all SPT tumors contain a mutation in the β-catenin gene; however, the histogenetic origin of this tumor remains largely a mystery. E-cadherin is a cell adhesion molecule that links to catenins to form cell adhesion junctions, which is associated with the cytoskeleton formation. In this study, we examined the expression of E-cadherin and β-catenin from SPT in an attempt to determine the molecular basis for the unusual ...

TY - JOUR. T1 - Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status. AU - Means, Casey. AU - Clayburgh, Daniel. AU - Maloney, Lauren. AU - Sauer, David. AU - Taylor, Matthew H.. AU - Shindo, Maisie. AU - Coussens, Lisa. AU - Tsujikawa, Takahiro. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction. Methods: Immune complexity profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 patients with PTC, and were assessed for correlations with aggressive histopathological features based on the presence of lymphovascular invasion and/or extrathyroidal extension, and BRAF V600E mutational status. Results: mIHC ...

Synchronous primary cancers are occasionally observed, but TTM is extremely rare; only about 100 cases have been reported in the English literature. Campbell et al. [7] proposed the concept of TTM, which can be distinguished from collision tumor based on following criteria: 1) more than one primary tumor; 2) the recipient tumor may be a true benign or malignant neoplasm; 3) the metastatic neoplasm is a true metastasis with established growth within the host tumor, not the result of contiguous growth (collision tumor) or tumor emboli; 4) primary tumors spreading into the lymphatic system in the setting of generalized lymphoreticular malignancy are excluded.. According to the seed and soil hypothesis [8] of cancer metastasis, interactions between cancer cells (seed) and specific organ microenvironments (soil) determine the outcome of metastasis. Renal cell carcinoma and meningioma are both highly vascularized tumors, and have high lipid and glycogen content, which can provide a fertile ...

Introduction. Solid pseudopapillary neoplasm (SPN) of the pancreas is rare, accounting for 2-3 % of primary pancreatic tumours (1). It was first described by Frantz in 1959 and has since then been referred to as: solid and cystic tumour, solid and papillary neoplasm, Frantzs tumour, papillary-cystic neoplasm and papillary epithelial neoplasm. It was finally defined by the World Health Organization (WHO) in 2000 as a solid pseudopapillary neoplasm of the pancreas (2). SPN is considered a low malignant potential neoplasm, due to its benign morphology and the fact that it rarely metastasizes (3). Even though pancreatic tumours generally have bad prognosis, SPN shows good prognosis, which makes the disease entity unique in this disease group. To predict malignant behavior of SPN, several morphological criteria are needed (angioinvasion, invasion to surrounding tissue or unequivocal perineural invasion) and if present, the tumour should be designated as solid pseudopapillary carcinoma (SPC) (4). We ...

Thyroid cancer, the commonest of endocrine malignancies, continues increasing in incidence being the 5th more prevalent cancer among women in the United States in 2012. Familial thyroid cancer has become a well-recognized, unique, clinical entity in patients with thyroid cancer originating from follicular cells, that is, nonmedullary thyroid carcinoma. Hereditary nonmedullary thyroid cancer may occur as a minor component of familial cancer syndromes (familial adenomatous polyposis, Gardners...

Objective: Describe a case of a patient diagnosed with papillary thyroid carcinoma by a retropharyngeal tumor.. Methods: A 46-year-old male was referred from the otorhinolaryngology consult to our department with the post-operative diagnosis of papillary thyroid carcinoma, with 6 months history of upper airway dyspnea and dysphagia to solids. Physical examination: right side adenopathies, not painful on palpation. No goitre. Laryngoscopy: hypertrophy of right posterior pharyngeal wall, epiglottis with rotation. Glotis was permeable. Mobile vocal cords. Pyriform sinus free. Cervical and thoracic TC: right retropharyngeal and internal jugular adenopathic conglomerates. Subcentimetrical mediastinal lymph nodes. Nasopharyngeal MRI: right retropharyngeal paracentral mass rejecting adjacent structures. FNA of cervical lymph node: lymph node with metastases of papillary thyroid carcinoma.. Results: Surgical treatment is decided. Transcervical excision was performed in right parapharyngeal tumor, ...

TY - JOUR. T1 - Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations. AU - Attia, Doaa. AU - Lurie, Alexander. AU - Zhai, Qihui. AU - Smallridge, Robert. PY - 2020/6/30. Y1 - 2020/6/30. N2 - BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3.6 cm right thyroid nodule and a smaller lesion in the left lobe in 2007; both were FV-PTCs with no lymphovascular invasion or metastases. In 2015, a positron emission tomography-CT scan showed a small defect in the left posterior lateral fifth rib with mild increased hypermetabolic activity with standardised uptake value of 3.9 and another lesion in the right hip at the junction of the femoral neck ...

Introduction: We report an unusual case of adenocarcinoma of lung metachronous with stage IVA papillary thyroid carcinoma. The two tumors are morphologically similar; and the later presence of lung mass could clinically masquerade as metastatic thyroid carcinoma. We discuss the challenges in clinical, imaging and pathologic diagnosis. Case Report: A 64-year-old non-smoking female had a thyroidectomy and neck lymph node dissection for a stage IVA tumor with pathologic findings of one 2 mm microcarcinoma of left thyroid and six positive cervical lymph nodes. The post-surgical I131 whole body scan was negative and thyroglobulin is suppressed and stable (

TY - JOUR. T1 - The role of positron emission tomography/computed tomography in the management of recurrent papillary thyroid carcinoma. AU - Nahas, Zayna. AU - Goldenberg, David. AU - Fakhry, Carol. AU - Ewertz, Marjorie. AU - Zeiger, Martha. AU - Ladenson, Paul W.. AU - Wahl, Richard. AU - Tufano, Ralph P.. PY - 2005/2/1. Y1 - 2005/2/1. N2 - Objectives/Hypothesis: The aim of the study was to evaluate the role of combined positron emission tomography/computed tomography (PET/CT) fusion imaging in the detection and management of recurrent papillary thyroid cancer. Study Design: A retrospective analysis of 33 patients with suspected recurrent papillary thyroid carcinoma who had undergone PET/CT was performed. PET/CT was compared with standard imaging techniques in each patient to determine whether PET/CT contributed to the therapeutic management plan. Histopathological findings were correlated to PET/CT in patients who imderwent surgery. Methods: The senior author reviewed the charts of 33 ...

|i|Background.|/i| Papillary thyroid carcinoma (PTC) is a form of thyroid cancer with high risk of cervical lymph node metastasis. |i|Aim.|/i| The aim of this study was to investigate the incidence and the predictive factors for occult ipsilateral central lymph node (CLN) metastasis in the patients with papillary thyroid carcinoma. |i|Methods.|/i| A total of 916 PTC patients (1017 lesions) undergoing central lymph node dissection in our hospital from 2005 to 2011 were enrolled. The relationship between CLN metastasis and clinical factors such as gender, age, tumor size, tumor number, capsule invasion, and tumor location was analyzed. |i|Results.|/i| Occult CLN metastasis was observed in 52.41% (533/1017) of PTC lesions, respectively. Multivariate analysis showed that age ≤ 35 years, tumor size > 1.5 cm, present capsule invasion/extracapsular invasion, and tumor located in upper/middle pole/whole lobe were risk factors of CLN metastasis. |i|Conclusions.|/i| Tumor located in upper

Through a transcriptome microarray analysis, we have isolated Anterior gradient protein 2 (AGR2) as a gene up-regulated in papillary thyroid carcinoma (PTC). AGR2 is a disulfide isomerase over-expressed in several human carcinomas and recently linked to endoplasmic reticulum (ER) stress. Here, we analyzed the expression of AGR2 in PTC and its functional role. Expression of AGR2 was studied by immunohistochemistry and real time PCR in normal thyroids and in PTC samples. The function of AGR2 was studied by knockdown in PTC cells and by ectopic expression in non-transformed thyroid cells. The role of AGR2 in the ER stress was analyzed upon treatment of cells, expressing or not AGR2, with Bortezomib and analyzing by Western blot the expression levels of GADD153. PTC over-expressed AGR2 at mRNA and protein levels. Knockdown of AGR2 in PTC cells induced apoptosis and decreased migration and invasion. Ectopic expression of AGR2 in non-transformed human thyroid cells increased migration and invasion and

Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low-grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that ,1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area. The pathological features of the two tumors, including solid and pseudopapillary growth patterns with pale or eosinophilic cytoplasm, were characteristic of SPTs of the pancreas. However, in the case of the metastatic ovarian tumor, focal necrosis and an increased nuclear-to-cytoplasmic ratio were observed. The presence of positive nuclear-cytoplasmic β-catenin, ...

Tumor invasiveness is directly related to the ability of tumor cells to migrate and invade surrounding tissues, usually degrading extracellular matrix. Despite significant progress in the knowledge about migration and invasion, there is much more to elucidate about their regulatory mechanisms, especially in cancer cells. MicroRNAs (miRs) were recently described as important regulators of migration. Differential expression of miRs in cancer is frequently associated with progression, invasion and metastasis. In papillary thyroid carcinoma (PTC), miR-146b-5p is highly expressed and positively correlated to the degree of malignancy. This study aimed to investigate the role of miR-146b-5p on the migratory and invasive behaviors of thyroid cells, using a non tumor rat thyroid follicular cell line (PCCl3) transfected with the miR-146b-5p genomic region, and two PTC cell lines (TPC-1 and BCPAP, bearing distinct oncogenic backgrounds), which express high levels of miR-146b-5p, after miR-146b inhibition by

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Aims: Metastatic nodes on power Doppler sonography tend to demonstrate high intranodal resistance and abnormal distribution of vascularity within a node. However, in our experience metastatic nodes from papillary carcinoma of the thyroid frequently demonstrate low intranodal resistance and some do not demonstrate the presence of any abnormal vascularity within. We were therefore interested to document these features. Materials and Methods: The grey scale and power Doppler sonograms of 21 metastatic nodes from papillary carcinoma of the thyroid were evaluated. The intranodal distribution of vessels and the intranodal vascular resistance of vessels was assessed and compared with the reported features of metastatic nodes from other head and neck primaries. Results: A majority (17/20, 85%) of metastatic nodes from papillary carcinoma of the thyroid had a maximum resistance index (RI) and pulsatility index (PI) , 0.8 and 1.6, respectively. A majority of the nodes (16/21, 76%) demonstrated abnormal ...

Solid pseudopapillary tumor of the pancreas (SPTP) is a rare pancreatic tumor. Rarely does the tumor have a multicentric location. We report this unusual case of a 24-year-old woman who had 2 large synchronous SPTPs detected incidentally by routine p

Pancreas: Solid pseudopapillary tumour of the pancreas with t(11;22)(q24;q12) EWSR1/FLI1, Authors: Jean-Loup Huret. Published in: Atlas Genet Cytogenet Oncol Haematol.

Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The RET/PTC-RAS-BRAF linear molecular signaling cascade is known to mediate PTC pathogenesis. However, whether presence of BRAF mutation, the most common genetic alteration in PTC, can affect PTC behavior and prognosis is controversial. MicroRNAs (miRNAs) have been labeled as promising molecular prognostic markers in several tumor types. Our recent studies demonstrated that microRNA-146b (miR-146b) deregulation is associated with PTC aggressiveness and prognosis. Here we summarize the current knowledge related to the functional roles, regulated target genes, and clinical applications of miR-146b in PTC and discuss how these studies provide insights into the key role of miR-146b as an oncogenic regulator promoting

BACKGROUND:This paper aimed to evaluate the expression of REGg and characterize its clinical significance in papillary thyroid carcinoma (PTC). MATERIAL AND METHODS:In total, 54 patients with PTC who underwent partial or total thyroidectomy and cervical node dissection for PTC from February 2009 to September 2011 were retrospectively reviewed. Thyroid specimens and metastatic lymph nodes from 54 patients and normal thyroid tissues obtained from 13 volunteers were collected and analyzed. Tumor size, T-stage, and lymph nodes metastasis were recorded based on surgical pathology. Immunohistochemical (IHC) technology was performed to analyze REGg protein expression level. Corrections between the expression of REGγ and the clinicopathological factors were analyzed. RESULTS:All the normal thyroid tissues were REGg-negative. REGγ was positive in 75.9% (41/54) of PTC tissues, of which 29 cases (29/42, 69.0%) were in T1-T2 stage and 12 cases (12/12,100%) were in T3-T4 stage. Positive REGγ was found in 21 cases

Title: Oncogene profile of papillary thyroid carcinoma. Author: Sugg, Sonia L. / Ezzat, Shereen / Zheng, Lei / Freeman, Jeremy L. / Rosen, Irving B. / Asa, Sylvia L.. Reference: Surgery, 125 (1), p.46-52, Jan 1999. doi: 10.1016/S0039-6060(99)70287-4. Abstract: …suppressor genes in thyroid cancer is a subject of intense…a group of papillary thyroid cancers. Mutations…radiation fallout from the Chernobyl nuclear accident…oncogene rearrangement in thyroid cancer and other potentially…. URL: http://www.sciencedirect.com/science/article/pii/S0039606099702874. ...

Yim JH , Kim WB , Kim EY , Kim WG , Kim TY , Ryu JS , Gong G , Hong SJ , Shong YK. J Clin Endocrinol Metab April, 2011. The primary treatment of locoregionally recurrent/persistent papillary thyroid cancer (PTC) is surgical removal by reoperation. This study evaluated the efficacy of the first reoperation for loco-regionally recurrent/persistent papillary thyroid carcinoma and the usefulness of stimulated TG for evaluating efficacy of reoperation. A retrospective observational cohort study was done in a tertiary referral hospital. A total of 83 patients, who underwent initial total thyroidectomy and nodal dissection with radioactive iodine remnant ablation, received reoperation for loco-regionally recurrent/persistent PTC and were included in this study. Stimulated TG levels were assessed before and after reoperation. We assessed biochemical remission (stimulated TG,1 ng/ml) after reoperation and evaluated second clinical recurrence-free survival rate according to stimulated TG value. There was ...

Micropapillary carcinoma (MPC) is a rare variant of carcinoma, and it is composed of small papillary neoplastic cell clusters lying within clear lacunar spaces that simulate lymphovascular channels. This tumor has been described in the several organs such as the breast, lung, urinary bladder and salivary gland and it is known to be frequently associated with a high incidence of lymphatic invasion and metastasis in lymph nodes, resulting in poor clinical outcome. We present here a case of MPC in the gall bladder, and this type of case has not been previously described. Histologically, the tumor was composed of micropapillary carcinoma with tight clusters of micropapillary aggregates in the background of tubular adenoma. Focal invasive micropapillary components were also noted in the submuscular connective tissue. A metastatic lesion in a regional lymph node also showed an entirely micropapillary pattern. ...

Nucleotides are increasingly recognized as non-redundant extracellular signals for chemotaxis, cell growth and cytokine release. Effects of extracellular nucleotides are mediated by P2 receptors, among which the P2X7 subtype is attracting increasing attention for its involvement in apoptosis, cell growth and cytokine release. Recent studies showed that P2X7 is overexpressed in chronic lymphocytic leukemia, breast and prostate cancer. The aim of the present study was to better understand the clinical significance of P2X7 receptor expression in normal and cancer human thyroid tissues. P2X7 receptor message and protein expression and functional activity were tested in two cell lines (FB1 and FB2) established from either anaplastic and papillary primary thyroid cancer and in several histological samples of human papillary cancer. We show here that human thyroid papillary carcinoma, whether of the classical or follicular variant, express the P2X7 receptor (P2X7R) to a much higher level than normal ...

Papillary thyroid cancer, which is the most common type of thyroid cancer, makes up about 80% of all cases of thyroid cancer. It is one of the fastest growing cancer types with over 20,000 new cases a year. In fact, it is the 8th most common cancer among women overall and the most common cancer in women younger than 25. Although a person can get papillary thyroid cancer at any age, most patients will present before the age of 40.

Results-On VTI elastography: score 1 was found in 84 nodules (all benign); score 2 in 37 nodules (3 papillary carcinomas and 34 benign nodules); score 3 in 25 nodules (1 medullary carcinoma, 6 papillary carcinomas, and 18 benign nodules); score 4 in 53 nodules (50 papillary carcinomas and 3 benign nodules); score 5 in 17 nodules (14 papillary carcinomas and 3 benign nodules); and score 6 in 3 nodules (all papillary carcinomas). A VTI elasticity score of 4 or greater was highly predictive of malignancy (P, .01), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 87.0% (67 of 77), 95.8% (136 of 142), 91.8% (67 of 73), 93.1% (136 of 146), and 92.7% (203 of 219), respectively. The κ values were 0.69 for intraobserver agreement and 0.85 for interobserver agreement ...

Summary Global Markets Directs, Papillary Thyroid Cancer - Pipeline Review, H1 2016, provides an overview of the Papillary Thyroid Cancer pipeline landscape. The report provides comprehensive information on the therapeutics under development for Papillary Thyroid Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA

TY - JOUR. T1 - Outcome predictors and impact of central node dissection and radiometabolic treatments in papillary thyroid cancers ≤2 cm. AU - Perrino, Michela. AU - Vannucchi, Guia. AU - Vicentini, Leonardo. AU - Cantoni, Gianmaria. AU - Dazzi, Davide. AU - Colombo, Carla. AU - Rodari, Marcello. AU - Chiti, Arturo. AU - Beck-Peccoz, Paolo. AU - Fugazzola, Laura. PY - 2009. Y1 - 2009. N2 - The incidence of papillary thyroid cancer (PTC) is rapidly growing, the recorded increase being mainly related to tumors ≤2 cm. The re-classification of tumors ,1 and ≤2 cm limited to the thyroid from the T2 to the T1 category triggered some concerns about their best management. In order to identify possible predictors of disease outcome, several clinico-pathological features were analyzed by uni- and multivariate analyses in a retrospective consecutive series of 251 PTCs ≤2 cm. Moreover, since 37% of cases were submitted to prophylactic central compartment node dissection (CLND, VI-VII levels) and ...

Multiple studies have shown that papillary microcarcinomas are very low risk and are unlikely to grow and/or spread. As such, there is significant interest in confirming whether or not thyroid surgery can be avoided for at least some people diagnosed with papillary microcarcinoma. The purpose of the study is to provide better understanding of the risk of cancer growth and spread for patients diagnosed with papillary thyroid microcarcinoma to determine whether or not thyroid surgery is needed for such patients. ...

immune Uncategorized Dovitinib Dilactic acid, Rabbit Polyclonal to CEBPD/E Papillary thyroid carcinomas (PTCs) occasionally form multiple tumor foci in various sites of the same thyroid gland. demonstrated a concordant inactivation design Dovitinib Dilactic acid from the X-chromosome. AS-PCR indicated that mutational position between your tumor foci was discordant in three (25%) and concordant in nine (75%) of 12 obtainable situations. Once the total outcomes of the two molecular analyses had been mixed, 28.6% from the cases were discordant in X-chromosome inactivation design and/or mutation, recommending multicentric origin. A number of the remaining concordant situations could be of multicentric origins also. These total outcomes support a hypothesis that multicentric incident in multiple PTCs could be common, possibly higher than 30%. Even though specific system of multicentric incident is normally unclear still, our findings donate to the understanding the histogenesis of papillary thyroid ...

eng] INTRODUCTION: Proliferation and apoptosis are opposing processes by which the cell numbers are kept in a delicate balance, essential for tissue homeostasis, whereas uncontrolled growth of cells is a hallmark of cancer. Papillary thyroid cancer (PTC) is the commonest type of thyroid cancer, with some PTC following an indolent course, whereas the other ones are more aggressive. AIM: To evaluate respective contribution of proliferation and apoptosis in the tumorigenesis of PTC by automated analysis. MATERIALS AND METHODS: We investigated the immunolabeling of phosphorylated histone H3 (pHH3), cyclin D1, active caspase-3, and bcl-2 in thirteen cases each of metastatic PTC, follicular variant of PTC (FVPTC), papillary microcarcinoma (PMC) and well differentiated tumor of uncertain malignant potential (WDT-UMP). FVPTC cases comprised seven encapsulated and six unencapsulated cases. RESULTS: Proliferation, as assessed by pHH3 and cyclin D1 immunolabeling, was increased in all PTC variants, ...

The main nonmedullary form of thyroid cancer is papillary thyroid carcinoma (PTC) that accounts for 80-90% of all thyroid malignancies. Only 3-10% of PTC

The planning of surgery methods and patient evaluation in the thyroid cancer surgery has been subjected to up to date discussions with the over again description of cytological classification after the development of high-resolution ultrasound and fine needle aspiration biopsy. Papillary carcinomas consist of nearly 85% of all thyroid cancers and of them papillary thyroid microcarcinomas (PTM) constitute 30-56%. At the late 1980s, PTM defined as the papillary thyroid carcinomas (PTC) those are ≤1 cm at the largest diameter. In the international guidelines of thyroid cancer diagnosis and management, PTM and PTC diagnosis are the main factors that effect the surgical method. The management steps of papillary thyroid cancer begin with surgical removing of the primary tumor, the part overspilling from thyroid capsule and affected lymphoid ganglions. The main principle is retaining the morbidity in minimal during surgery with the extent of surgery according with ...

Papillary carcinoma (PTC) is the most common form of well-differentiated thyroid cancer, and the most common form of thyroid cancer to result from exposure to radiation. Papillary carcinoma appears as an irregular solid or cystic mass or nodule in a normal thyroid parenchyma.

Unusual presentation of papillary thyroid carcinoma: about two cases.: The papillary carcinoma is the most common cancer of thyroid but its presentation may be

Background: Inactivation of p16 by methylation of CpG islands is a frequent early event in human cancers, including papillary thyroid carcinoma (PTC). This study was to observe the methylation status of the p16 gene in papillary thyroid carcinoma (PTC) and its correlation with clinical parameters.. Methods: Methylation-specific PCR (MSP) was used to analyze the methylation status of the p16 gene in 74 PTCs and 21 adjacent normal thyroid tissues.. Results: Hypermethylation of p16 gene was observed in 27.0% (20/74) of PTC. None of the normal thyroid tissues was methylated, when compared to the PTCs (p < 0.05). There was no marked relationship between the methylation of p16 gene and the patients′ age, gender, size of cancer, histological subtypes and occurrence of recurrent disease (p > 0.05). The methylation of p16 gene was positively associated with metastasis, a high AMES (age, metastasis to distant sites, extrathyroidal invasion, size) risk group (p < 0.05) and advanced pathological tumor ...

A Germline CHEK2 Mutation in a Family with Papillary Thyroid Cancer. Thyroid. 2020 Feb 11;: Authors: Zhao Y, Yu T, Chen L, Xie D, Wang F, Fu L, Cheng C, Li Y, Zhu X, Miao G Abstract Approximately 5% of all cases of PTC are inherited. However, the susceptibility gene(s) for nonsyndromic familial papillary thyroid carcinoma (FPTC) remain unclear. We performed whole genome sequen...

These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...

Classical papillary thyroid microcarcinoma (PTMC) is a variant of papillary thyroid carcinoma (PTC) known to have excellent prognosis. It has a mortality of 0.3%, even in the presence of distance metastasis. The latest American Thyroid Association guidelines state that although lobectomy is acceptable, active surveillance can be considered in the appropriate setting. We present the case of a 37-year-old female with a history of PTMC who underwent surgical management consisting of a total thyroidectomy. Although she has remained disease-free, her quality of life has been greatly affected by the sequelae of this procedure. This case serves as an excellent example of how first-line surgical treatment may result more harmful than the disease itself. ...

Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand the effect of MiR-144-3p in papillary thyroid carcinoma (PTC) as well as the associated mechanisms. Real-time PCR, immunohistochemical and Western blot assays were performed to examine the expression of target miRNA and/or genes. CCK-8 and flow cytometry analysis was used to respectively test cell growth, cell cycle progression and apoptosis. Luciferase reporter assay was performed to find out whether miR-144-3p could bind to the 3′ untranslated region of PAX8 or not. We found that PAX8 decreased in PTC, while miR-144-3p increased in PTC. Over-expression of miR-144-3p promoted the cell viability and cell cycle progression. The expressions of cell-cycle-related genes, cyclin D1, cyclin-dependent kinase 2 and CDC25A were modulated by miR-144-3p. Meanwhile, the presence or absence of miR-144-3p both

TY - JOUR. T1 - Synchronous papillary thyroid carcinoma with mucinous rectal carcinoma. AU - Barreto, S. G.. AU - Shet, T.. AU - Shrikhande, S. V.. AU - Shukla, P. J.. N1 - This article is available under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License (CC BY-NC-SA), which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use.. PY - 2009/10/1. Y1 - 2009/10/1. UR - http://www.scopus.com/inward/record.url?scp=70350279171&partnerID=8YFLogxK. U2 - 10.4103/0377-4929.56122. DO - 10.4103/0377-4929.56122. M3 - Letter. C2 - 19805981. AN - SCOPUS:70350279171. VL - 52. SP - 577. EP - 579. JO - Indian Journal of Pathology and Microbiology. JF - Indian Journal of Pathology and Microbiology. SN - 0377-4929. IS - 4. ER - ...

Recently, the rearrangement of RET proto-oncogene has been reported to be the most common genetic change in papillary thyroid carcinoma (PTC). However, its prevalence has been reported variably and its relation to clinical outcome has been controversial. The characteristic nuclear features of PTC ...

I was diagnosed with Eosinophilic Esophagitis and severe food allergies in June of 07 then with thyroid papillary carcinoma in December. Now they want to do Lupus tests and possibly others. I have a lo...