The long-lasting phase of precursors of invasive cancer, i.e. dysplasia or intraepithelial neoplasia (IEN), is particularly relevant among risk determinants. At present, about 15-20% of all breast cancers are diagnosed in a non-invasive phase. Despite their good prognosis, women with breast IEN (lobular and ductal intraepithelial neoplasia, LIN and DIN) have a 10-15/1000 annual risk of invasive disease (8-10 times the same age general population), and thus represent an important target for chemoprevention. In the National Surgical Adjuvant Breast and Bowel Project (NSABP-P1 trial), tamoxifen use at 20 mg/day was associated with a 86% reduction of invasive breast cancer in women with previous atypical ductal hyperplasia (ADH) (RR=0.14, 95% IC, 0.03-0.47) and with a 56% risk reduction in women with previous Lobular Carcinoma in situ (LCIS) (RR=0.44, 95% IC, 0.16-1.06). However, tamoxifen use in this setting is hampered by serious adverse events attributable to its partial estrogenic activity, such ...
In this study, three different groups of lesions have been identified by using immunohistochemical profiling for MIB-1, p53 and Bcl-2. The first group contains florid and atypical ductal and lobular hyperplasias, well-differentiated ductal carcinoma in situ and lobular carcinoma in situ. The second group contains poorly differentiated ductal carcinoma in situ, whereas the third group shows heterogeneous staining and contains intermediate ductal carcinoma in situ. Two possible models of neoplastic progression could explain these results. In the first model, progression could occur from the group containing the well-differentiated ductal carcinoma in situ to intermediate and finally to poorly differentiated ductal carcinoma in situ with a progressive increase in both proliferation and p53 expression and loss of Bcl-2 expression. An alternative model suggests that low grade ductal carcinomas and lobular carcinomas in situare derived from the florid and atypical hyperplasias as they share a common ...
Introduction: With the emerging importance of the tumor immune environment in both invasive and preinvasive breast cancer, vaccine therapy may provide a well-tolerated, durable therapy for preinvasive breast cancer by preventing both recurrent preinvasive disease and progression to invasive disease. Preinvasive breast cancer is ideal for vaccines because the disease is slow growing and the patients are not immunosuppressed. However, design of the vaccines are critical including consideration of appropriate antigens, selecting Th1 stimulating epitopes, and using multiantigen vaccines to address tumor heterogeneity.. ...
Squamous microcarcinomas of the uterine cervix represent a focus of controversy regarding a useful clinical definition. The confusion of terminology and numerous pathological definitions have led to a great variety of surgical treatments from the con
Information that explains what Ductal Carcinoma In Situ (DCIS) is, and how it is diagnosed and treated. This page also recommends other sources of information.
In situ cancers and invasive cancers often are treated in the same way but for different reasons. After all, we dont have too many options. We can save the breast, we can save the breast and then radiate it or we can do mastectomies. And in selected circumstances, each of these treatments is applicable to patients with in situ cancers and with invasive cancers.
The occurance and clinical course of human papillomavirus (HPV)-induced lesions is largely determined by the nature of the cellular immune defense generated. Even tough both genital warts and vulvar intraepithelial neoplasia (VIN) are HPV-associated genital lesions they differ in their risk of malignant progression. Imiquimod (IMQ) is a topically applied Toll-like receptor (TLR) 7 agonist that has been approved for the treatment of superficial (pre-) carcinomas of the skin (basal cell carcinomas, actinic keratosis) and HPV-associated lesions (genital warts). It acts by activation of the immune system exerting anti-tumor and anti-viral properties. The aim of the study is to evaluate the mechanisms of IMQ treatment and to analyze the differences in HPV-affected and non affected tissue at cellular and molecular level as determined by immunofluorescence stainings and real time PCR, respectively ...
Human papillomavirus type 16 (HPV-16)-associated vulval intraepithelial neoplasia (VIN) is frequently a chronic, multifocal high-grade condition with an appreciable risk of progression to vulval cancer. The requirement to treat women with VIN has recently stimulated the use of immunotherapy with E6/E7 oncogene vaccines. Animal models have shown that E2 may also be a useful vaccine target for HPV-associated disease; however, little is known about E2 immunity in humans. This study investigated the prevalence of HPV-16 E2-specific serological and T-cell responses in 18 women with HPV-16-associated VIN and 17 healthy volunteers. E2 responses were determined by full-length E2-GST ELISA with ELISPOT and proliferation assays using E2 C-terminal protein. As positive controls, HPV-16 L1 responses were measured using virus-like particles (VLPs) and L1-GST ELISA with ELISPOT and proliferation using VLPs as antigen. The VIN patients all showed a strong serological response to L1 compared with the healthy ...
TY - JOUR. T1 - Natural history of bronchial preinvasive lesions. AU - Ishizumi, Taichiro. AU - McWilliams, Annette. AU - MacAulay, Calum. AU - Gazdar, Adi. AU - Lam, Stephen. PY - 2010/3. Y1 - 2010/3. N2 - Preinvasive bronchial lesions defined as dysplasia and carcinoma in situ (CIS) have been considered as precursors of squamous cell carcinoma of the lung. The risk and rate of progression of preinvasive lesions to invasive squamous cell carcinoma as well as the mechanism of progression or regression are incompletely understood. While the evidence for the multistage, stepwise progression model is weak with relatively few documented lesions that progress through various grades of dysplasia to CIS and then to invasive carcinoma, the concept of field carcinogenesis is strongly supported. The presence of high-grade dysplasia or CIS is a risk marker for lung cancer both in the central airways and peripheral lung. Genetic alterations such as loss of heterozygosity in chromosome 3p or chromosomal ...
The American Cancer Society estimates that more than 62,000 news cases of carcinoma in situ will be diagnosed this year. A common type of c
Vulvar cancer is a malignant persistent growth in the vulva. It is reported for about 4 % of all type of gynecological cancers as well as affects usually women in later life. It is guessed that in 2006, in the United States, about 3,740 new instances of Vulvar cancer will be diagnosed. About 880 women will pass away as a consequence of vulvar cancer. Vulvar carcinoma is detached from a non-invasive lesion of the epithelium, vulvar intraepithelial neoplasia(VIN), which can improve through carcinoma-in-situ to squamous cell cancer. Even, Paget disease of the vulva can be formed. It is caused by the squamous cell carcinoma that creates from the epidermis of vulva tissue.. ...
There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia, nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic ratio. Mitotic activity is abundant. Several atypical mitoses are identified. The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A sizable portion of the lesion show some maturation to the surface (AIN 2). Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal interface is well-demarcated. Focal ulceration is present. The margin of the biopsy has severely dysplastic epithelium (AIN 3). ...
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Lobular carcinoma in situ (LCIS) is an uncommon condition where benign (non-cancer) change is seen within the lobules of the breast.
The current best hope for the successful treatment of pancreatic cancer is the removal of pre-invasive lesions before they become malignant. The early detection...
Feline Bowenoid in situ carcinoma (BISC) is a rare disease that presents as multiple discrete plaques of epidermal hyperplasia and dysplasia
The diagnosis of any of the listed below conditions must be established by histological evidence and be confirmed by a specialist in the relevant field.. Carcinoma-in-situ (CIS):. Carcinoma-in-situ means the presence of malignant cancer cells that remain within the cell group from which they arose. It must involve the full thickness of the epithelium but does not cross basement membranes and it does not invade the surrounding tissue or organ. The diagnosis of which must be positively established by microscopic examination of fixed tissues.. Prostate Cancer - early stage:. Early Prostate Cancer that is histologically described using the TNM classification as T1N0M0 with a Gleason Score 2 (two) to 6(six).. Thyroid Cancer - early stage:. All thyroid cancers that are less than 2.0 cm and histologically classified as T1N0M0 according to TNM classification. Bladder Cancer - early stage:. All tumors of the urinary bladder histologically classified as TaNoMo according to TNM classification.. Chronic ...
Very sorry for the necessity that drew you here. This link is compiled by the Am Cancer Soc and its pretty comprehensive. Print it out. There is room to write the answers if you print it out. If possible, have someone come with you to take notes. If you miss something or dont quite understand what they say, ask them to repeat it in plain English. If you think of it after the appt, dont worry. Call the office back with the question. The drs. nurse will call back with the info. If you have to have lung cancer, this is the slowest growing cancer which is fairly good news. There are fewer options for treatment at this time but with the advent of the newer targeted therapies in clinical trial, chances are very good that they will have several options in use before you need it. If they recommend lobectomies or wedges or both, you may never need further intervention. This may be overwhelming at first, but, it is survivable. Please let us know what the drs say. Dont be afraid to get a second opinion. ...
A 33-year-old woman with a 2.7 cm high grade, comedo type DCIS, which was accurately assessed by both MRI and mammography.A. Spot-magnification mediolateral obl
Номер такой: WVWZZZ3BZ3P093310 Помнится, у кого-то были выходы на ВИНопробойник. Посмотреть бы че за комплектация, че за зверь такой. :-k Кажется, у Axla. Спасибо! Жду :gaz:
Topical 5-aminolevulinic acid-based photodynamic therapy (PDT) has produced complete response rates of ,90% for nonmelanoma skin carcinomas, which are mostly human papillomavirus (HPV) negative. Using a similar treatment protocol, we observed a short-term response in only one third (10 of 32) of high-grade vulval intraepithelial neoplasia (VIN 2-3) lesions. Unifocal lesions were found more responsive than multifocal and pigmented lesions. Animal model studies have suggested that long-term PDT response involves an immune reaction in which CTLs play a crucial role. In this study, we have assessed: (a) HPV infection; (b) HLA expression; and (c) immune infiltrating cells in VIN biopsies from responders and nonresponders to determine whether these factors may limit response to topical 5-aminolevulinic acid-based PDT. Tissues from normal vulva (n = 9), vulval carcinoma (n = 11), and VIN (32 patients from which 19 pre- and 43 post-PDT biopsies were taken) were investigated for immune cell infiltration ...
... J Obstet Gynaecol. 2019 Oct 14;:1-5 Authors: Gurumurthy M, Leeson S, Tidy J, Cruickshank ME Abstract Vaginal intraepithelial neoplasia (VaIN) is less common than intraepithelial neoplasia at other non-cervical sites and can be challenging to manage. This survey describes current clinical practice by col...
Background: The detection of vaginal intraepithelial neoplasia (VAIN) in cervical samples is not a common finding. Therefore, we aimed to report VAINs detected in liquid-based cytology (LBC) from women examined at Hospital das Clínicas of Faculty of Medicine, Sao Paulo State University. Materials and Methods: We evaluated LBC samples from women referred to gynecology examination for different reasons (previous abnormal PapTest, follow up of treated cervical lesion, ecc) and women examined for regular screening proposals, and compared with biopsy diagnoses, including the controversial diagnoses of vaginal intraepithelial neoplasia (VAIN). Results: From 1866 patients, 1423 (76.3%) cases were negative and 443 (23.7%) were positive for any cellular alteration. Age of patients ranged from 12 to 86 years. We detected 25 histologically confirmed VAIN (1.3% p = 0.0002 by Fishers exact test IC 95% 0.0090 - 0.0198) and 1.1% VAIN (p = 0.0031 by Fishers exact test IC 95% 0.0077 - 0.0179). Conclusion
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Sirolimus in Preventing Invasive Breast Cancer in Patients with Ductal Carcinoma In Situ, Lobular Carcinoma In Situ, Atypical Lobular Hyperplasia, or Atypical Ductal Hyperplasia - NCT02642094
Pathology Histologic Classification of Vaginal Neoplasia. VAIN (VAginal Intraepithelial Neoplasms). These are pre-malignant lesions of the vaginal squamous epithelium that can develop primarily in the vagina or as an extension from the cervix. Histologically, VAIN is defined in the same way as cervical intraepithelial neoplasia (CIN). Classification includes three grades: Grade 1 (VAIN I = mild dysplasia); Grade 2 (VAIN II = moderate dysplasia); and Grade 3 (VAIN III = severe dysplasia or carcinoma in situ). Invasive carcinoma:. ...
Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS.. Methods: To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), associated with risk of invasive BC, in 1317 BCIS cases, 10,645 invasive BC cases, and 14,006 healthy controls in the National Cancer Institutes Breast and Prostate Cancer Cohort Consortium (BPC3). Using unconditional logistic regression models adjusted for age and study, we estimated the association of SNPs with BCIS using two different comparison groups: healthy controls and invasive BC subjects to investigate whether BCIS and BC share a common genetic profile.. Results: We found that five SNPs (CDKN2BAS-rs1011970, FGFR2-rs3750817, FGFR2-rs2981582, TNRC9-rs3803662, 5p12-rs10941679) were ...
This study assessed the efficacy and tolerability of imiquimod in HIV-infected patients with high-grade intraepithelial neoplasia. The primary measure of
Doctors and the general public are increasingly recognising diseases of the vulva and vagina as a cause of sexual dysfunction, morbidity and death, yet the wide but sometimes rare range of conditions involving this area are poorly represented in most textbooks of pathology. As the first volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists, Pathology of the Vulva and Vagina is one of the very few dealing wholly with this subject.Pathology of the Vulva and Vagina introduces the topic with a stylishly illustrated description of the embryology and development which is fundamental to understanding the pathogenesis and symptomatology. Subsequent chapters cover infections and non-infectious dermatoses, specifying those that can predispose to cancer. The precancerous conditions of vulval intraepithelial neoplasia, melanocytic proliferations and extra-mammary Pagets disease are integrated respectively with accounts of ...
Description of disease Breast, infiltrating lobular carcinoma of the. Treatment Breast, infiltrating lobular carcinoma of the. Symptoms and causes Breast, infiltrating lobular carcinoma of the Prophylaxis Breast, infiltrating lobular carcinoma of the
Melissas Rap: When I was 21, I discovered a lump in my breast. After multiple doctors appointments, mammograms and ultrasounds, my doctor decided I should have it surgically removed. Before the surgery, doctors found another lump in my other breast. So, I had bilateral biopsies. Thankfully, both were benign. Ever since that year, I have…
Although anal cancer is a rare disease, its incidence is increasing in men and women worldwide. The most important risk factors are behaviors that predispose individuals to human papillomavirus (HPV) infection or immunosuppression. Anal cancer is generally preceded by high-grade anal intraepithelial neoplasia (HGAIN), which is most prevalent in human immunodeficiency virus (HIV)-positive men who have sex with men. There is a general consensus that high-risk individuals may benefit from screening. Meta-analysis suggests that 80% of anal cancers could be avoided by vaccination against HPV 16/18. Nearly half of all patients with anal cancer present with rectal bleeding. Pain or sensation of a rectal mass is experienced in 30% of patients, whereas 20% have no tumor-specific symptoms. According to the Surveillance Epidemiology and End Results (SEER) database, 50% of patients with anal cancer have disease localized to the anus, 29% have regional lymph node involvement or direct spread beyond the primary, and
It seems like every year, a new recommendation is coming down the pipeline about the best ways to prevent and diagnose breast cancer. Navigating all of the confusion can be difficult, so Ive got a …. Continue Reading about New Annual Mammogram Guidelines-Some Things Every Woman Should Know → ...
Characteristics of lobular carcinoma and LCIS. Pictures showing the difference, and mentioning possible symptoms, mammogram findings and treatment.
The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of Kras. However, expression of mutant Kras alone is not sufficient to drive pancreatic ductal adenocarcinoma (PDAC) in adult mice. Obesity is a metabolic disorder and is a risk factor for PDAC. One of the main factors that contributes to the development of obesity is high-fat consumption. Recent studies have demonstrated that High-Fat-Diet (HFD) can promote oncogenic Kras mediated development of pancreatic intraepithelial neoplasia and PDAC. However, it is not clear why mice with oncogenic KrasG12D expression are predisposed to HFD mediated pancreatic carcinogenesis. Here, we report that Ras activity dramatically reduces the expression of fibroblast growth factor 21 (FGF21). FGF21 is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 lower serum free fatty acids and lead to weight loss in obese mice. FGF21 is highly expressed in pancreatic acinar cells and is a potential ...
As expected the US Food and Drug Administration has opened the door to Merck & Cos Gardasil vaccine for the prevention of anal cancer anal intraepithelial neoplasia. - News - PharmaTimes
Vaginal Cancer, In a recent study, the incidence of vulval, vaginal or anal intraepithelial neoplasia was 1.96 per 100 person-years for the HIV-infected women and 0.26 per 100 person-years fo... ...
To compare the lesion distribution and the extent of the disease in ductal and lobular carcinomas of the breast, we studied 586 ductal and 133 lobular consecutive cancers. All cases were documented on large-format histology slides. The invasive component of ductal carcinomas was unifocal in 63.3% (371/586), multifocal in 35.5% (208/586), and diffuse in 1.2% (7/586) of the cases. The corresponding figures in the lobular group were 27.8% (37/133), 45.9% (61/586), and 26.3% (35/133), respectively. When the distribution of the in situ and invasive component in the same tumors was combined to give an aggregate pattern, the ductal carcinomas were unifocal in 41.6% (244/586), multifocal in 31.6% (185/586), and diffuse in 26.8% (157/586) of the cases. The corresponding figures in the lobular category were 15.0% (20/133), 54.2% (72/133), and 30.8% (41/133), respectively. Ductal cancers were extensive in 45.7% (268/586), lobular in 65.4% (87/133) of the cases. All these differences were statistically ...
Answers from trusted physicians on what are the treatment options for lcis. First: Lcis is somewhat of a misnomer in that it is not a cancer, but a "pre-malignant" condition in which there are abnormal cells present in the glands (lobules) of the breast. Therefore patients with a diagnosis of lcis are at a higher risk of developing breast cancer than the general population and require closer observation and screening. Hormonal therapy may be used in those with very high risk.
Baktearjen (wittenskiplike namme: Bacteria, iental Bacterium) binne (iensellige) mikro-organismen, dyt sa lyts binne dat se allinnich ûnder in mikroskoop te sjen binne. In wichtige eigenskip fan baktearjen is, dat se har hurd fermearderje kinne. In baktearje is in prokaryoat en hat dus gjin selkearn. It erflike materiaal sweeft om yn it sytoplasma. It DNA bestiet meastal út mar ien ringfoarmich gromosoam, faak beselskippe troch ien of mear plasmiden, dyt ek genetyske ynformaasje befetsje. Baktearjen kinne ûnderling plasmiden útwikselje (konjugaasje), wêrtrocht se rekombinearje. Sa ûntsteane allegeduerigen nije bacterievariëteiten. De Bakteria waarden eartiids Eubakteria neamd. Yn it algemiene spraakgebrûk wurdt meastal gjin ûnderskied makke tusken Bacteria ("gewoane" baktearjen) en Archaea (oerbaktearjen), dyt tegearre de groep prokaryoaten foarmje. Yn de taksonomy foarmje de Bakteria lykwols in ôfsûnderlik Ryk of Domein. Blaualgen of blauwieren, dyt gjin echte algen of wieren ...
Intímny sprchový gél na hygienu žien vo fertilnom veku, vhodný po športovaní, počas menštruácie, pri gynekologických problémoch a zápachu intímnych partií
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Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. DNA samples from 28 cervical adenocarcinoma, 55 squamous cell carcinoma and 31 intraepithelial neoplasia grade 3 (CIN3), previously characterized in terms of human papillomavirus (HPV) prevalence and genotype distribution, were analyzed for TP53 and PIK3CA mutations in the exons 4-9 and exon 9, respectively. Single nucleotide substitutions in TP53 and PIK3CA genes were detected in 36% and 11% of adenocarcinoma, in 16% and in 5% of squamous cell carcinoma, and in 13% and none of CIN 3, respectively. Nucleotide changes in TP53 were significantly more frequent in adenocarcinoma cases than in squamous cell carcinoma and CIN3 (P = 0.035) and were independent from HPV infection
TY - JOUR. T1 - Effect of antiretroviral therapy on the incidence of genital warts and vulvar neoplasia among women with the human immunodeficiency virus. AU - Massad, L. Stewart. AU - Silverberg, Michael J.. AU - Springer, Gayle. AU - Minkoff, Howard. AU - Hessol, Nancy. AU - Palefsky, Joel M.. AU - Strickler, Howard D.. AU - Levine, Alexandra M.. AU - Sacks, Henry S.. AU - Moxley, Michael. AU - Watts, D. Heather. PY - 2004/5. Y1 - 2004/5. N2 - Objective: The purpose of this study was to determine the incidence and predictors of genital warts and vulvar intraepithelial neoplasia among women with the human immunodeficiency virus. Study design: This was a multicenter prospective cohort study comprised of women without warts or vulvar intraepithelial neoplasia at baseline who underwent CD4 count, human immunodeficiency virus RNA measurement, examination, Papanicolaou test, and biopsy, as indicated, every 6 months. Human papillomavirus DNA typing was examined at baseline. Results: The incidence of ...
The molecular mechanisms of vulvar squamous cell carcinoma (VSCC) remain Dactolisib obscure. hierarchical cluster analysis. Further processing included functional analysis and overrepresentation calculations based on Gene Ontology Database for Annotation Visualization and Integrated Finding and Ingenuity Pathway Analysis. The molecular phenotypes of VSCC individuals exhibited significant and discrete transcriptional variations from the healthy controls whereas principal component analysis recorded that this separation is mediated by a consistent set of gene manifestation differences. We recognized 1077 genes (306 upregulated and 771 downregulated) that were differentially indicated between VSCC individuals and healthy settings by at least twofold (< .01) whereas a novel subset of individuals was revealed displaying a distinct pattern of 125 upregulated genes involved in multiple cellular processes. Functional analysis of the 1077 genes recorded their involvement in more than 50 signaling ...
Invasive lobular carcinoma (ILC), sometimes called infiltrating lobular carcinoma, is the second most common type of breast cancer after invasive ductal carcinoma. About 10% of all invasive breast cancers are invasive lobular carcinomas. Learn about the diagnosis and treatment of invasive lobular carcinoma.
Cancer occurs when abnormal tissue cells reproduce uncontrollably. Cancer can develop anywhere in the body, and the symptoms and treatment depend on the type of cancer and its location. There are various types of cancer that can affect the female reproductive organs, including vulvar cancer.. Vulvar cancer is a cancer of the vulva, or a females external genitals. The vulva includes the inner and outer lips of the vagina, the clitoris, and the opening of the vagina, which is called the introitus. Glands near the vaginal opening are also part of the vulva. Vulvar cancer typically affects the outer lips of the vagina, but other parts of the vulva may also be affected, especially as the cancer enlarges.. This type of cancer usually develops slowly. It often begins as vulvar intraepithelial neoplasia, which occurs when healthy skin cells around the vulva undergo abnormal changes. Without treatment, the abnormal cells can turn into cancer.. ...
Genital infection with low-risk types of HPV is associated with genital warts in men. Infection with high-risk types of HPV is associated with a proportion of preinvasive squamous lesions of the penis (penile intraepithelial neoplasia or PIN) and with penile cancer, as well as with preinvasive squamous lesions of the anus (anal intraepithelial neoplasia or AIN) and with anal cancer.. Invasive penile cancer is quite uncommon, especially in circumcised men.. In 2002, the age-adjusted incidence rate for penile cancer in the U.S. was 0.8 per 100,000 men (985 new cases). The age-adjusted incidence rate for anal cancer was 1.2 per 100,000 men (1,453 new cases). However, the risk of anal cancer for MSM is significantly higher.. Because of the increased incidence of anal cancer in MSM, especially HIV-infected MSM, some specialists recommend screening for AIN by cytology in this population. However, there are limited data on the natural history of AIN, the reliability of screening methods, the safety and ...
The progression from precursor lesions of pancreatic cancer, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN), to invasive disease is characterized by stepwise accumulation of genetic alterations. However, it remains unclear whether additional alterations are required for the progression of high-grade neoplasms to invasive pancreatic carcinoma. We compared the genomic profiles of paired noninvasive and invasive carcinoma tissues collected from patients with IPMN. We demonstrate that the frequency of genomic copy-number aberrations significantly increased during the course of invasion, and the loss of 8p11.22-ter was more often associated with invasive tissues. Expression profiling in pancreatic cancer cell lines with and without 8p11.22-ter revealed that DUSP4, an MAPK phosphatase, was significantly downregulated in cells lacking 8p11.22-ter as well as in invasive carcinomas due to genomic loss. Restoration of DUSP4 expression in pancreatic cancer ...