We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. ...

TY - JOUR. T1 - Bilobectomy for Bronchogenic Carcinoma. AU - Keller, Steven M.. AU - Kaiser, Larry R.. AU - Martini, Nael. PY - 1988/1/1. Y1 - 1988/1/1. N2 - During a 12-year period, bilobectomy was performed on 166 patients for the treatment of primary lung carcinoma: 108 patients (65%) underwent right upper and middle lobectomy, while 58 patients (35%) underwent right middle and lower lobectomy. Indications for bilobectomy were tumor extending across a fissure (45%), absent fissure (21%), endobronchial tumor (14%), extrinsic tumor or nodal invasion of bronchus intermedius (10%), and vascular invasion (5%). Thirty-one patients (19%) suffered 41 perioperative complications, and 7 patients (4.2%) died. Upper and middle lobectomies were not associated with a significantly different morbidity (p , 0.10) or mortality (p , 0.10) when compared with middle and lower lobectomy. The postoperative chest roentgenograms of all patients demonstrated ipsilateral volume loss, and 31 patients were found to have ...

A patient is described with small cell carcinoma of the lung, associated with profound hypophosphataemia and hyponatraemia. Increased phosphate excretion and inappropriately high urine osmolality were observed. The abnormalities are consistent with tumoral hypophosphataemia and inappropriate antidiuresis. These tumour-related metabolic abnormalities have only been described once before with this malignancy.. ...

This is often referred to as bronchogenic carcinoma. It is recognized as being one of the most common complications of asbestos exposure and it invariably causes death. Asbestos induced carcinoma of the lung is one of the most fatal of the common cancers.. 80% of all people who contract bronchogenic carcinoma die within two years of diagnosis being made. It is not necessary for a worker to have asbestosis in order to attribute bronchogenic carcinoma to asbestos exposure. The attribution can be made if there has been sufficient exposure to asbestos dust.. Pleural Mesothelioma ...

Right lung upper lobe apical segment bronchogenic cancer with pleural invasion as well as malignant mediastinal and right hilar metastatic lymphadenopathy and right pleural effusion.

Acinar cell carcinoma of lung|Adenocarcinoma of lung|Adenocarcinoma of lung (disorder)|Adenocarcinoma of lung, stage I|Adenocarcinoma of lung, stage I (finding)|Adenocarcinoma of lung, stage II|Adenocarcinoma of lung, stage II (finding)|Adenocarcinoma of lung, stage III|Adenocarcinoma of lung, stage III (finding)|Adenocarcinoma of lung, stage IV|Adenocarcinoma of lung, stage IV (finding)|Adenoid cystic carcinoma of lung|Adenosquamous carcinoma of lung|Alveolar cell carcinoma|BC - Bronchogenic carcinoma|Basaloid squamous cell carcinoma of lung|Bronchial carcinoma|Bronchiolar adenocarcinoma|Bronchiolar carcinoma|Bronchioloalveolar carcinoma|Bronchioloalveolar carcinoma (disorder)|Bronchioloalveolar carcinoma - disorder|Bronchoalveolar cancer|Bronchogenic carcinoma|CA - Cancer of bronchus|CA - Carcinoma of bronchus|CA - Lung cancer|Cancer of bronchus|Carcinoma of bronchus|Carcinoma of lung|Carcinoma of lung parenchyma|Carcinoma of lung parenchyma (disorder)|Carcinosarcoma of lung|Clear cell squamous cell

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Four-drug combination chemotherapy (methotrexate, cyclophosphamide, hexamethylmelamine, and CCNU) for non-small cell bronchogenic carcinoma: A cancer and leukemia group B study. Journal of Clinical Oncology. 1983 ...

Summary: This review focuses on the cavitary lesions that are encountered in oncology patients, including primary bronchogenic carcinoma, pulmonary metastas...

Traditionally, high technical morbidity and mortality and uncertain long-term survival have been associated with carinal surgery for bronchogenic carcinoma. However, growing evidence exists that judicious indications, meticulous surgery, and also perioperative management can decrease surgical mortal …

Tracheobronchial foreign body (TFB) aspiration is a common occurrence in children compared with adults. Long-standing cases of TFB aspiration during childhood presenting in an adult have rarely been reported. We report the unique case of an endobronchial Playmobil traffic cone that went undetected for 40 years and presented as a suspected bronchogenic carcinoma. This was subsequently removed successfully with flexible bronchoscopy. To our knowledge this is the first case of a TFB that was overlooked this length of time. ...

Background & objective: The histologic distinction of small cell from non-small cell lung carcinoma and correct identification of all subtypes of lung carcinoma are very important in treatment management. The main method for histologic classification of lung tumors is based on morphology. However, in small bronchoscopic biopsies in particular, distinction is very difficult upon morphology alone. The current study aimed at evaluating the utility of a panel of antibodies, consisting of thyroid transcription factor (TTF-1), P63, high molecular weight keratin [HMWK (34βE12)], cytokeratin (CK7), and cluster of differentiation (CD56) for accurate distinction of bronchogenic carcinomas. Methods: Bronchoscopic biopsies of 60 lung carcinoma cases including 20 small cell carcinomas, 20 adenocarcinomas, and 20 squamous cell carcinomas (SCCs) with typical morphologic features were selected. All these cases were immunohistochemically stained for TTF-1, P63, HMWK (34βE12), CK7, and CD56. All immunostained slides

TY - JOUR. T1 - Cisplatin-etoposide induced myocardial infarction in a patient with small cell carcinoma. AU - Katta, Srija. AU - Chauhan, Sheetal. AU - Singh, Ajit. AU - Shetty, Prasad N.. AU - Kareem, Hashir. AU - Devasia, Tom. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Various drugs used to treat cancer cause hemodynamic/physiological changes in various organs of the body. Cardiotoxicity is one of the major side effects. Cardiotoxicity associated with chemotherapy can range from asymptomatic sub-clinical echocardiographic changes to life-threatening events like congestive heart failure or acute coronary syndrome. We present a case of cisplatin and etoposide-induced myocardial infarction (MI) during the second cycle of chemotherapy for bronchogenic carcinoma of the left lung (small cell carcinoma). The patient developed troponin positive NSTEMI and was managed conservatively. Here, the possible mechanism of action and the importance of cardiac screening while using cisplatin and etoposide are ...

Although the lung is not usually considered a major target organ of sex hormones, epidemiological observations, studies of pulmonary neoplasms in laboratory animals, and investigations of carcinomas derived from other nontarget organs suggest that sex hormones may have a role in the pathogenesis of bronchogenic carcinoma. To confirm that estrogen (ER) and progesterone receptors are present in human lung cancers, 19 resected lung cancers were examined for receptors using a prelabeled sucrose gradient method. Three squamous cell carcinomas were positive for ER (,6.9 fmol/mg cytosol protein). Three squamous cell carcinomas, two adenocarcinomas, and one small cell carcinoma were positive for progesterone receptors (,6.9 fmol/mg cytosol protein). One tumor, a squamous cell carcinoma arising in a woman who smoked, had an ER level of 301 fmol/mg, a highly positive level even for breast cancers. These observations may provide a basis for adjuvant hormonal therapy in selected lung cancer ...

The proportion of elderly patients presenting with bronchogenic carcinoma is increasing. To study the impact of age on clinical presentation, management and outcome of patients, the authors have reviewed their clinical experience over the last 20 yrs. Between 1977 and 1996, 1,079 patients underwent thoracotomy for primary lung carcinoma in the authors institution. Patients were grouped by age at the time of surgery as ,60 yrs, 60-69 yrs and , or =70 yrs. Although the mode of clinical presentation was similar between all age groups, patients ,60 yrs were more prone to have advanced stage carcinoma at the time of diagnosis. The rates of exploratory thoracotomy and pneumonectomy were higher in patients ,70 yrs, whereas lobectomies and lesser resections largely predominated in patients , or =70 yrs. The mortality rate following lobectomy and lesser resection increased from 1.3% in patients ,60 yrs to 5.5% in patients , or =60 yrs (p=0.04) and the mortality rate following pneumonectomy increased ...

Despite extensive research, the role of the commonly employed tumour markers in the diagnosis of lung carcinoma is yet to be clarified. The utility of a new marker, CYFRA 21-1, in the preoperative evaluation of patients with bronchogenic carcinoma was investigated. CYFRA 21-1 was determined with a radiometric assay in serum of 280 patients with lung cancer and 208 patients with various nonmalignant lung diseases. The levels of the marker were significantly higher in lung cancer patients. Among benign lung diseases, elevated CYFRA 21-1 levels were found in pulmonary fibrosis. Using a cut-off of 3.2 ng.ml-1 (95th percentile of levels obtained in benign lung disease), the total sensitivity of the marker was 48%. The best sensitivity was obtained in squamous cell lung cancer (60%). The highest values of CYFRA 21-1 were found in metastatic lung cancer, and the marker sensitivity was more elevated in stage IIIb and IV. On the other hand, 40% of patients with surgically resectable lung cancer had CYFRA ...

The subject of malignant disease of the lung, particularly bronchogenic carcinoma, appears to be a suitable one for such an occasion as this for many reasons. It is a condition of considerable importance owing to its increasing incidence; it clearly illustrates the advance in diagnosis and treatment in chest disease obtained during the last 20 years. It affords, in all its various aspects, opportunities to all sections of this association for study, and, lastly, it is a subject which has always been of considerable interest to me personally (excerpt from A Tudor Edwards).1. Above the readers of todays Thorax will find the introduction to the first article ever published in this journal. The article was written by A Tudor Edwards and is based upon his presidential address to the association for the study of diseases of the chest on 27 July 1945. Despite the fact that this address was given 60 years ago and about 2 months after VE day celebrations signalling the end of World War II, it could just ...

There was no mortality, serious complications or transfusion.. Conclusion. Mediastinoscopy allows accurate information from biopsies of lymph nodes. In our series, the majority (68.2%) showed non-malignant granulomatous diseases, predominantly TB 29.5%, sarcoidosis 14.8%, and concurrent sarcoidosis and TB 12.5%. In the West, 83% are diagnosed with malignancy, of which 81% have lung cancer.2 TB is now uncommon in the West. Pakistan ranks 6th in the estimated global TB burden list, with an incidence of 181/100000, and prevalence 359/100000.4. Sarcoidosis is a diagnostic challenge in countries where TB is endemic.5 The estimated prevalence of sarcoidosis in this series was 27%, which seems higher than the West (12%).2 A series from India reports 18%.1 In our study, the prevalence of bronchogenic carcinoma was 24% and lymphoma 4.5%. Eight (33.3%) of these had N0 and N1 disease and underwent resection of the primary tumours. Thirteen (61.9%) were diagnosed with N2 or N3 disease and were spared a ...

1. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. eds. Introduction and historical overview. In: Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. eds. AJCC Cancer Staging Manual. 7th ed., 2010, Springer; p. xiii.. 2. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997; 111 (6): 1710-1717.. 3. Sobin LH, Wittekind C eds. Lung and pleural tumours. In: Sobin LH, Wittekind C eds. UICC International Union Against Cancer, TNM classification of malignant tumours, 6th ed. New York: Wiley-Liss, 2002; pp. 97-107.. 4. Naruke T, Tsuchiya R, Kondo H, Asamura H. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM staging classification: the Japanese experience. Ann Thorac Surg 2001; 71(6): 1759-1764.. 5. Ginsberg RJ. Continuing controversies in staging NSCLC: an analysis of the revised 1997 staging system. Oncology (Williston Park) 1998; 12 (1 Suppl 2): 51-54.. 6. Paci M, Sgarbi G, Ferrari G, De Franco S, Annessi ...

Belongs to a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in the body. To be more effective it is sometimes used in combination with other chemotherapy medications. Used to treat lymphomas, multiple myeloma, leukemias, mycosis fungoides, neuroblastoma, ovarian carcinoma, retinoblastoma, breast cancer, Ewings sarcoma, bronchogenic carcinoma, small cell lung carcinoma, and other types of cancer. Also known as Cytoxan.

SCLC accounts for approximately 15% of bronchogenic carcinomas. At the time of diagnosis, approximately 30% of patients with SCLC will have tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes. These patients are designated as having limited-stage disease (LD).[1] Patients...

Fig. 11. Routine control of an 82-year-old man after surgery for carcinoma of the larynx ten years ago. PA view shows abnormal right hilum and blurring of the left cardiac contour (A, arrow). Lateral view shows marked forward displacement of the left major fissure (B, arrows) indicating severe LUL collapse, confirmed to be due to bronchogenic carcinoma.. In conclusion, the following areas should be investigated in the lateral view:. The anterior clear space, to evaluate lesions that are not visible in the PA radiograph, the most common being anterior mediastinal masses.. The posterior clear space; the most frequent abnormality in this area is pleural effusion.. The retrocardiac space; Hiatal hernia is the most common finding.. The lung fissures, to detect displacement that may herald the presence of a central carcinoma.. Next time, Ill finish with the checklists.. ...

A patient with watery diarrhea syndrome secondary to bronchogenic carcinoma responded to treatment with clonidine and lidamidine. Stool weight decreased to 43% and 53% of control on two separate trials of clonidine. Stool weight decreased to 35% of control during a trial of lidamidine. Both clonidine and lidamidine increased sodium and chloride absorption in vitro in human intestine. Clonidine, lidamidine, or drugs that are structurally similar may become therapeutic choices for secretory diarrhea. ...

28 late cases of malignancy of all pathologically proven were evaluated. Among them are one case of melanoma, two cases of non-Hodgkin lymphoma (NHL), twenty cases of gastro-intestinal cancers, three cases of bronchogenic carcinoma, one case each of primary hepatocellular carcinoma and multiple peritoneal malignancies of unknown origin respectively.. ,Click Here for Detail,. ...

Introduction Overall, colorectal cancer ranks second only to bronchogenic carcinoma among the cancer killers. Adenocarcinomas constitute the vast majority of colorectal cancers and represent 70% of all malignancies arising in the gastrointestinal tract.

A 32 year old female life long non-smoker with a history of mild asthma, previously well ... Bronchogenic carcinoma D) Atelectasis E) Lung abcess

SIADH. Alexander Usorov, MD July 31, 2007. SIADH. Most frequent cause of hyponatremia First described by Schwartz et al in 1957 in 2 pts with bronchogenic carcinoma Arginine vasopressin was then identified. ADH. Synthesized in hypothalamus Transported down to posterior pituitary...

Characteristics of the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery II (GCCB-S-II) and global description of their ...

We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.

Eloise Mikkonen from the University of Tampere, Finland, is part of a collaborative project investigating a connection between herpes simplex virus and Alzheimers disease. Thanks to a Travelling Fellowship from DMM, she visited her collaborators in Umeå University, Sweden, and the team have now published their work in DMM. Read more on her story here.. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 23 February 2018. Apply now!. Did you know that DMM also offers conference travel grants? Apply by 9 March 2018. Find out more here.. ...

SCLC represents approximately 15% to 20% of all bronchogenic malignancies and is biologically and clinically distinct from non-small cell types. Despite a good initial response to chemotherapy, most SCLC patients ultimately develop resistance and relapse. Because available therapies have little effect on survival, new therapeutic approaches are needed (28, 29). Epigenetic changes, such as DNA methylation and histone acetylation, have a central role in the control of gene transcription and are early events in lung tumorigenesis (1, 26, 30, 31). 5-AZA-dC and HDAC inhibitors can reactivate aberrantly hypermethylated or acetylated genes, thereby inhibiting tumor cells by inducing apoptosis, cell cycle arrest, and differentiation (32-35). In addition to its demethylating function, 5-AZA-dC may also play an antineoplastic role that is methylation independent (36, 37).. HDAC inhibitors alone inhibited growth in four of nine SCLC cell lines, whereas 5-AZA-dC alone inhibited growth in two cell lines ...

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Thirty-two patients with inappropriate secretion of antidiuretic hormone (ADH) complicating small-cell carcinoma of the bronchus were identified from a total of 226 patients with small-cell carcinoma of the bronchus treated at the Christie Hospital, Manchester, between 1978 and 1984. Basic data were collected from patients files concerning the extent of the tumour, symptoms of inappopriate secretion of antidiuretic hormone, biochemical findings, treatment, the course of the inappropriate secretion of ADH and that of the underlying tumour. The data were then analysed and compared with results of previous studies. The response of the inappropriate secretion of ADH to treatment was found to be a significant prognostic factor. Further data were collected to determine the reason for this but it was difficult to drawn any firm conclusions. ...

TY - JOUR. T1 - Lung function following upper sleeve lobectomy for bronchogenic carcinoma. AU - Brusasco, Vito. AU - Ratto, Giovanni B.. AU - Crimi, Paolo. AU - Sacco, Andrea. AU - Motta, Giovanni. PY - 1988. Y1 - 1988. N2 - Eight patients who underwent upper sleeve lobectomy and six who underwent upper simple lobectomy for lung cancer were studied. The two groups were matched for age and preoperative lung function as assessed by standard spirometry. Post-operative lung function studies, including measurements of regional ventilation (V·r) and perfusion (Q·r) by 133 Xenon technique showed that: 1) two weeks after surgery, forced expiratory volume at 1 s was more reduced after simple than after sleeve lobectomy, but in both groups V·r and its vertical gradient were similarly reduced in the operated lung compared to the contralateral; 2) one year after sleeve lobectomy, the vertical gradient of V·r tended to disappear in both lungs while V·r and V·r/Q·r of the operated side increased ...

Looking for online definition of bronchogenic cancer in the Medical Dictionary? bronchogenic cancer explanation free. What is bronchogenic cancer? Meaning of bronchogenic cancer medical term. What does bronchogenic cancer mean?

Definitive histology of the specimen was infiltrating colloid adenocarcinoma with immunophenotype of enteric adenocarcinoma arising from a benign cystic mucoid lesion compatible with bronchogenic cyst. Immunohistochemical staining was positive for cytokinin 20 and CDX 2, and negative for cytokinin 20 and TTF1. Mediastinal lymph nodes were not affected.. The final diagnosis was enteric adenocarcinoma arising from a bronchogenic cyst. No additional lesions were found on colonoscopy and further abdominal exams. Because no signs of disease dissemination were found, no additional therapy was applied. The patient is alive without recurrence of disease 6 months after the surgery.. Bronchogenic cysts are congenital lesions thought to originate from the primitive ventral foregut,2 and are the result of abnormal budding that pinches off from the tracheal tree in the stage when bronchial buds develop into the primitive of respiratory tree.9,10 Bronchogenic cysts are relatively rare, with a prevalence of ...

TY - JOUR. T1 - Supradiaphragmatic bronchogenic cyst extending into the retroperitoneum. AU - Jo, Won-Min. AU - Shin, Jae Seung. AU - Lee, In Sung. PY - 2006/1/1. Y1 - 2006/1/1. N2 - We experienced a case of bronchogenic cyst located on the left lower pleural space extending into the retroperitoneum in a 33-year-old man with left chest pain. Preoperative imaging studies and operative findings showed a broad-based cystic mass on the left lower posterior pleura and diaphragmatic pleura extending into the retroperitoneal region across the diaphragm. Histologic studies proved this mass to be a bronchogenic cyst.. AB - We experienced a case of bronchogenic cyst located on the left lower pleural space extending into the retroperitoneum in a 33-year-old man with left chest pain. Preoperative imaging studies and operative findings showed a broad-based cystic mass on the left lower posterior pleura and diaphragmatic pleura extending into the retroperitoneal region across the diaphragm. Histologic studies ...

Do You Have Bronchogenic Cyst? Join friendly people sharing true stories in the I Have Bronchogenic Cyst group. Find support forums, advice and chat with groups who share this life experience. A Bronchogenic Cyst anonymous support group with informat...

Pancoast tumour, otherwise known as superior sulcus tumour, refers to a relatively uncommon situation where a primary bronchogenic carcinoma arises in the lung apex at the superior pulmonary sulcus and invades the surrounding soft tissues. Termi...

Bronchogenic cysts are rare congenital anomalies that arise in early gestation as a result of abnormal budding of the developing respiratory system.1 Abnormal bronchi or bronchioles may form large saccular structures that may later form cystic lesions. Bronchogenic cysts predominantly occur in males and are often solitary and rarely multiple. Typically, bronchogenic cysts have ciliated epithelium with cartilage, smooth muscles, and mucus-producing bronchial glands similar to the bronchial walls. Bronchogenic cysts do not have alveolar structures because the abnormal budding occurs before the formation of the alveoli. Their location varies and depends on the embryonic stage of development at which the abnormality happens. Intrathoracic bronchogenic cysts have 2 radiographic classifications based on location: mediastinal and intrapulmonary. Mediastinal bronchogenic cysts account for approximately 20% of all primary mediastinal masses.2 Mediastinal bronchogenic cysts appear as smooth, rounded, ...

Bronchogenic cysts are small, solitary cysts or sinuses, most typically located in the region of the suprasternal notch or over the manubrium. Bronchogenic cysts are formed in the 6th week of gestation from an abnormal budding of the tracheal diverticulum. They are lined by respiratory type (ciliated) epithelium, which is characterized by cilia. Histologically these are also composed of cartilage, smooth muscle, fibrous tissue and mucous glands. These cysts originate from the ventral foregut that forms the respiratory system. These cysts are located close to the trachea or main stem bronchi. Rarely there is communication of the cyst with the tracheobronchial tree. These cysts are found most often in young adults and are rare in infancy. The usual symptoms are the result of compression by the cyst, e.g., difficulty breathing or swallowing, cough, and chest pain. Malignant degeneration has been reported in these cysts on rare occasions. Chest x-rays show a smooth density just in front of the ...

Mediastinal bronchogenic cysts are encountered relatively often, but in many cases, diagnosis using imaging modalities, is difficult. Early surgical excision of bronchogenic cysts is recommended as a...

Retroperitoneal bronchogenic cysts (BC) are rare clinical entities and may mimic an adrenal mass. Laparoscopic and retroperitoneoscopic approach is widely-used in adrenal surgery. However minimally- invasive resection of a periadrenally located BC has been reported rarely. Material and methods. A systematic review of PubMed has been performed using the following search strategy: bronchogenic cyst AND (adrenal OR retroperitoneal OR subdiaphragmatic). 18 BC being removed via minimally invasive approach have been found. Including our own case 7 were removed retroperitoneoscopically and 12 laparoscopically. Results. An index case of a 50 year old male is presented. CT revealed 2 masses above the left adrenal area. A control demonstrated an increase in size. Retroperitoneoscopic resection was performed. Pathologic finding showed a multilocular cystic lesion with a diameter of 4cm. The cysts were lined by pseudostratified ciliated epithelium. The wall contained hyaline cartilage, seromucous glands and ...

The mucoepidermoid carcinoma is a rare tumor arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. The low grade mucoepidermoid carcinoma is a characteristic and readily recognized tumor. The very rare high grade mucoepidermoid carcinoma must be distinguished with care from the much more common adenosquamous bronchogenic carcinoma. The present case was a 45-year-old female patient with a several-year history of right chest pain and a few-day-history of coughing, fever, dyspnea. Under the bronchoscopic impression of the bronchial adenoma, right middle and lower lobectomy was done. Grossly, the endobronchial mass, 1.2×1.2cm, was located at the mainsterm bronchus branching to middle and lower lobe. It was well circumscribed. It occluded most of the bronchus supplying the lower lobe. The cut surface was whitish gray, relatively smooth and firm. Microscopically, the tumor consisted ...

Thirty-two patients who presented with haemoptysis and in whom a chest radiograph showed no suggestion of a tumour are reviewed. Six had bronchogenic carcinoma diagnosed� by bronchoscopy and I had an adenoid cystic tumour of the trachea.

Background: Arsenicosis is a multisystem disorder that may affect virtually every organs of the body. The lung involvement in arsenicosis includes bronchitis, obstructive airway disease, bronchiectasis, diffuse parenchymal lung disease and bronchogenic carcinoma.. Objective: To report a rare case of arsenicosis causing bilateral bronchiectasis in a nine year old girl.. Presentation of Case: We describe a 9-year-old girl, who developed bilateral bronchiectasis in association with chronic arsenicosis caused by long-term consumption of homeopathic medicines for drug-resistant epilepsy. To the best of our knowledge, only few cases of bronchiectasis in connection with confirmed arsenicosis has been reported.. ...

Although the use of asbestos has been banned in most industrialized countries, it is still a major public health concern. Asbestos fibers are mutagenic and carcinogenic for humans, classified as carcinogen category 1 (T, R45: can cause the cancer) in the 25th adaptation of the directive 67/548/EEC. In France, asbestos is thought to be responsible each year for many pulmonary diseases: pleural plaque, bronchogenic carcinoma and mesothelioma (malignant tumor of pleura). In order to better understand the transformation process of pleural cells, we compared the gene expression of mesothelium cells (Met-5A) and mesothelioma cells (MSTO-211H) using high-density filter array (588 genes) and microarray (6.969 genes). Results of both technologies were compared and expression levels of several genes were confirmed by quantitative RT-PCR. Data analysis with GemtoolsTM 2.4 software allows us hierarchical classification of genes of known functions by enzyme, function and pathway clusters and leads to ...

Trade Name: Mustargen®. How is this drug used? Mechlorethamine is FDA approved for the treatment of advanced Hodgkins disease, lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, bronchogenic carcinoma, and metastatic cancer resulting in effusion. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Mechlorethamine belongs to a group of drugs called alkylating agents. Alkylating agents produce their anti-cancer effects by causing a chemical reaction that damages the DNA in a cell. The chemical reaction, called interstrand cross-linking, inhibits the cancer cell to grow or replicate and/or ultimately causes cellular death.. How is ...

There is preliminary evidence linking waterpipe use to disease, though this research is made difficult by the fact that many waterpipe users also smoke cigarettes24,27,66 and/or engage in other behaviours that may increase cancer risk.67 Waterpipe use likely increases the risk of bronchogenic carcinoma,68 as well as lung,16,20,69 oral,8 and bladder21,70 cancers. The notion that waterpipe use is associated with cancer is not surprising, given that, like cigarette tobacco, the tobacco used in waterpipes contains tobacco specific nitrosamines,71 and that waterpipe extract produces degeneration and hyperkeratosis in rat mucosa.72 Moreover, in a study comparing 35 healthy waterpipe users with 35 healthy, non-exposed controls, waterpipe use was associated with a significant increase in frequency of chromosomal aberrations and sister chromatid exchanges.63 While the sample size was low, there were obvious trends toward a dose dependent relation on these outcome measures when the data were analysed ...

There is preliminary evidence linking waterpipe use to disease, though this research is made difficult by the fact that many waterpipe users also smoke cigarettes24,27,66 and/or engage in other behaviours that may increase cancer risk.67 Waterpipe use likely increases the risk of bronchogenic carcinoma,68 as well as lung,16,20,69 oral,8 and bladder21,70 cancers. The notion that waterpipe use is associated with cancer is not surprising, given that, like cigarette tobacco, the tobacco used in waterpipes contains tobacco specific nitrosamines,71 and that waterpipe extract produces degeneration and hyperkeratosis in rat mucosa.72 Moreover, in a study comparing 35 healthy waterpipe users with 35 healthy, non-exposed controls, waterpipe use was associated with a significant increase in frequency of chromosomal aberrations and sister chromatid exchanges.63 While the sample size was low, there were obvious trends toward a dose dependent relation on these outcome measures when the data were analysed ...

Photodynamic therapy (PDT) utilizes a combination of sensitizer, visible light and molecular oxygen to generate singlet oxygen and reactive oxygen species (ROS) such as hydrogen peroxide, hydroxyl radical and superoxid anion. Photochemical reactions lead to damage and destruction of cancer cells. The most suitable and effective source of radiation used in PDT is a laser. For this study, a semiconductor laser with output power of 50 mW and 675 nm was selected. In this paper we report a generation of ROS using chloroaluminium disulphonated phthalocyanine (ClAlPcS2) in A549 bronchogenic carcinoma cell line after PDT in vitro. Phthalocyanines, belonging to a new generation of substances for PDT, exhibit effective tissue penetration because of their proper light absorption region, chemical stability and photodynamic stability. The fluorescence measurement with molecular probes, CM-H2DCFDA and Amplex Red, was performed for detection of ROS generation and hydrogen peroxide release from cells. Our ...

A bronchogenic cyst is an inherited condition in which a person has a cyst in the central area of his or her chest cavity, which...

Sep 18, 2018 - Find best Cardiothoracic Surgeons for Bronchogenic Cyst / Mass near you & make an appointment online instantly! Bronchogenic Cyst / Mass appointments are guaranteed and free!

The video shows laparoscopic enucleation of a bronchogenic cyst of esophagus with endoscopic evaluation. There is discussion in the end. Video by Pablo Omelanczuk,

PRIMARY OBJECTIVES:. I. To determine maximally tolerated light dose (MTID). Identify systemic and normal tissue toxicity using 2-[hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) for photodynamic therapy in patients with bronchogenic carcinoma-in-situ (CIS) or microinvasive carcinoma.. SECONDARY OBJECTIVES:. I. To study tumor response in patients with bronchogenic carcinoma-in-situ (CIS) or bronchogenic microinvasive carcinoma.. OUTLINE: This is a dose-escalation study.. Patients receive HPPH intravenously (IV) over 1 hour on day 1. Patients then photodynamic therapy with laser light on day 3. Patients also undergo therapeutic bronchoscopy for endoscopic debridement on day 5.. After completion of study treatment, patients are followed up at 4-6 weeks, 6 months, and then periodically for at least 2 years. ...

A bronchogenic cyst is congenital malformation of the foregut which was generally encountered within the mediastinum and detected in pediatric patients with symptoms of infection or compression on vital structures. They are rarely detected in adult population as a neck mass. We have recently experienced one case of bronchogenic cyst as a parathyroid mass in a 50-year-old female. It was incidentally detected by routine neck ultrasonography and interpreted as a parathyroid cyst with hemorrhage preoperatively, but confirmed as a bronchogenic cyst at pathologic examination. We report this case with review of literatures ...

Shorthouse, A J.; Smyth, J F.; Peckham, M J.; and Steel, G G., Comparison of the chemosensitivity of bronchial carcinoma xenografts with donor patients. Abstr. (1980). Subject Strain Bibliography 1980. 1141 ...

The co-incidence of synchronous intraepithelial neoplasia and early stage invasive lung cancer is not a rare phenomenon. The need for curative treatment and the invasive potential of squamous cell pulmonary carcinoma in situ have been a topic of controversy. Surgical resection still remains the treatment of choice. Varieties of endoscopic techniques such as brachytherapy were developed as an alternative to surgery in selected patients. External beam radiation therapy has been used traditionally in combination with endobronchial brachytherapy in the treatment of roentgenographically occult lung cancer, and can be offered for all patients, but is handicapped, because these tumors are radiographically invisible ...

TY - JOUR. T1 - 5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria. AU - Moro, Christian. AU - Edwards, Lily. AU - Chess-Williams, Russ. N1 - © 2016 The Japanese Urological Association.. PY - 2016/11. Y1 - 2016/11. N2 - OBJECTIVES: To examine the effect of 5-hydroxytryptamine (5-HT; serotonin) on the contractile properties of the urothelium and lamina propria, as a better understanding of bladder physiology might aid the development of new treatments.METHODS: Strips of porcine urothelium and lamina propria were suspended in gassed Krebs-bicarbonate solution, and cumulative concentration-response curves for 5-HT were generated in the absence and presence of 5-HT antagonists, Nω-nitro-l-arginine and indomethacin. Responses to α-methyl-5-HT were also examined.RESULTS: Strips of urothelium/lamina propria developed spontaneous contractions, whereas the addition of 5-HT induced concentration-dependent increases in contractile tone with maximal ...

INTRODUCTION. Nonbacterial endocardial vegetations of a specific morphologic and histologic pattern, and not attributable to other diseases, such as rheumatic fever or lupus erythematosus, have been described under various names. The appellations have usually attempted to denote the authors concept of its pathogenesis. The terms terminal and marantic endocarditis or endocardiosis imply a type of vegetation or valve change that terminates a chronic illness, and that it is a more or less incidental finding of only pathologic interest. There are many examples which do not terminate a long-term illness, such as carcinoma, but which may be seen in more or ...

An 11-month-old boy born of non-consanguineous marriage presented with a cough for 15 days and fever and breathlessness for 3 days. He had similar complaints at the age of 7 months and was hospitalized for same for 10 days and diagnosed as bronchiolitis and treated with IV antibiotics and nebulization. He was again hospitalized at 8 months of age for pneumonia and treated with IV antibiotics for 14 days. At that time, he was ventilated and bronchoalveolar lavage grew Klebsiella pneumoniae. He has had repeated episodes of cough and breathlessness and has been treated with antibiotics and steroids. On examination, the child had severe respiratory distress with decreased air entry on the left side. He was given nebulization, hydrocortisone but continued to develop stridor and difficulty in breathing. The child was then put under ventilator and condition improved. CT chest showed a retrotracheal bronchogenic cyst. The child underwent excision of the bronchogenic cyst and was alright after that ...

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