Background: Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are uncommon in the uterine cervix. .001). Conclusions: Even though the nuclei of both these buy 253863-00-2 tumor types had been oval formed, inferred through the ratio of small axis to main axis (0.728 in ACC and 0.669 in ABC), the region of nuclei was 1 approximately.7 times bigger in ACC than in ABC. Distinguishing nucleic features, including region, morphology, and chromatin design, may be useful in making the correct analysis. Keywords: Adenoid cystic carcinoma, Adenoid basal carcinoma, Genital smears, Papanicolaou check The World Wellness Firm (WHO) classifies malignant tumors from the uterine cervix into three classes: squamous tumors, glandular tumors, and additional epithelial tumors [1]. The group of additional epithelial tumors comprises five different tumor types: adenosquamous carcinoma, adenoid cystic carcinoma (ACC), adenoid basal carcinoma (ABC), neuroendocrine tumors, and undifferentiated carcinoma ...
Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to diagnose due to its rarity and limited data regarding its clinical behavior. We attempted to assess the degree of stromal invasion using magnetic resonance imaging (MRI) and evaluate possible treatments for this lesion in view of its clinical behavior. We analyzed 28 cases of PSCC diagnosed on the colposcopic selective biopsies. We studied the rate of accuracy of diagnoses of the colposcopic selective biopsies compared with the final diagnoses, and compared the rate of stromal invasion between the MRI and pathological findings while focusing on surgical methods and the clinical prognosis. Of the 28 patients, only 12 exhibited true PSCC. The other 16 patients were ultimately diagnosed with SCC or adenosquamous carcinoma based on the finding of the surgical specimens and exhibited relatively poor prognoses. Among the 12 true PSCC cases, the rate of diagnostic accuracy of stromal invasion (with or without) was only 58% (7/12) on
Five hundred and sixty-five cases of large bowel cancer were analysed. There were 8 (1.4%) appendiceal tumours, 296 (52.4%) colonic cancers, 236 (41.8%) rectal cancers, 6 (1.1%) anal cancers and 19 (3.4%) multiple primary cancers of the large bowel. Non-mucinous adenocarcinoma was by far the commonest histological type of large bowel cancer (74.7%). This was followed by mucinous carcinoma (20.7%). Other histological types were relatively uncommon. They included carcinoid tumours (1.8%), signet-ring cell carcinoma (1.5%), squamous cell carcinoma (0.7%), undifferentiated carcinoma (0.4%) and adenosquamous carcinoma (0.2%). The proportion of mucinous carcinoma was greater among the Indians and Malays than among the Chinese. There was a positive correlation between the grade and extent of spread of the tumour. The right colon had greater proportion of poorly differentiated adenocarcinomas than the left colon; this tendency was more evident in females. Mucinous carcinoma tended to occur more ...
Cervical cancer occurs primarily in 2 varieties: squamous cell carcinoma (about 80% of cases) and adenocarcinoma (about 15%). Adenosquamous carcinoma makes up most of the remaining cases, and this type may have a poorer outcome. A rare cause of death when screening programs exist, cervical cancer accounts for about 1% of all cancer deaths in developed countries. Cervical cancer is age related; incidence is extremely low in women under 20, and peaks at 16.5/100,000/year in women aged 45 to 49.1. Symptoms are absent in many cases, but abnormal vaginal discharge or bleeding often occurs. Advanced disease may also cause pain in the low back and pelvis with radiation into the posterior legs, as well as bowel or urinary symptoms such as passage of blood and a sensation of pressure. ...
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with pancreas cancer. PDAC is also the prototype of the pancreatobiliary-type adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability. Moreover, while PDAC is by far the most common cancer of the pancreas, there are various other types that occur in this organ and are erroneously classified together with PDAC. Many of these have different molecular and biologic characteristics that warrant their management separately although they are also technically pancreatic cancers. While some are closely related to PDAC and have as aggressive behavior (such as adenosquamous ...
This is a phase 2 study. Patients with advanced or metastatic histologically documented squamous cell carcinoma, adenocarcinoma, or adenosquamous cancers originating in the cervix, vagina, or vulva will be eligible. Measurable disease by either clinical exam or radiography is also required. Patients receiving cisplatin-based chemoradiation as definitive treatment for local disease will be eligible. Patients must have no more than one prior platinum-based chemotherapy regimen in the metastatic setting. Patients presenting with distant metastatic disease (beyond the pelvis) will be eligible, as long as they are not eligible for a higher priority study ...
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Mutations of the K-ras gene have been implicated in the pathogenesis of human lung adenocarcinomas. In most studies published so far, squamous cell lung cancers harbored ras mutations only exceptionally or no mutations were detected at all. We have examined 141 lung tumor DNA samples for mutations in codons 12, 13, and 61 of K-ras and H-ras oncogenes. A large panel of 118 squamous cell carcinomas was included in the study. For K-ras codon 12, we used a sensitive two-step PCR-restriction fragment length polymorphism method which detects ,1% of mutated DNA in the sample. K-ras mutations were found in 17 tumors (12%; 14 in codon 12 and 3 in codon 13). Among 19 adenocarcinomas, mutation was revealed in 7 samples (37%). Of these, one sample harbored two point mutations in codon 12. Nine mutational events were found in squamous cell carcinomas (8%, one adenosquamous carcinoma included, all in codon 12). Of four large cell carcinomas, one contained a mutation. Mutant-enriched PCR products harboring ...
TY - JOUR. T1 - Concomitant cisplatin and radiotherapy in locally advanced cervical carcinoma. AU - Runowicz, Carolyn D.. AU - Wadler, Scott. AU - Rodriguez-Rodriguez, Lorna. AU - Litwin, Peter. AU - Shaves, Mark. AU - OHanlan, Katherine A.. AU - Goldberg, Gary L.. AU - Tomainov, Catherine T.. AU - Byrnes, Richard. PY - 1989/9. Y1 - 1989/9. N2 - Patients with locally advanced cervical cancer have a poor prognosis. The efficacy of radiotherapy is limited by the presence of large tumor volume and nodal disease. As cisplatin is a documented radiosensitizer and has activity in squamous cell carcinomas, a prospective study was designed to evaluate the toxicity and potential synergism of concurrent cisplatin (20 mg/m2 × 5 d every 21 days) and radiotherapy in locally advanced cervical cancer. Forty-three patients were studied, of which 14 were stage IB/IIA (bulky disease) and 29 were stage IIB/IIIB/IVA. Of the 32 evaluable patients, there were 29 complete responders. Of these 29 patients, 27 remain ...
There were no significant differences in the clinicopathological characteristics of the patients. Mean age was 45 years (range 24 - 70). In both groups the histologies were squamous cell carcinoma (70%), adenocarcinoma (20%), and adenosquamous (10%). Stage distribution according to the FIGO was as follows: IB2, 22.5%; IIA, 10%; IIB, 67.5%, in both groups. Overall, 100% of patients completed external beam, and surgery or intracavitary brachyterapy. The majority of patients received the planned six courses of weekly cisplatin. At median follow-up (28 months; range 2-58 months), overall survival is 78% and 75% (p , 0.05) for the surgical and brachytherapy groups of patients. ...
Dr. Tom (Thomas Incledon) is the founder and CEO of Causenta Wellness, and the Causenta Cancer Treatment Center in Scottsdale, Arizona. Doctor Toms mission at Causenta is to Kill cancer once and for all with minimal side effects. Join Doctor Tom and the team at Causenta as he answers important questions about cancer treatment and wellness. Doctor Tom dives into breakthrough discussions on breast cancer, colon cancer, prostate cancer, pancreatic cancer, glioblastoma multiforme, Lung Cancer, Lung Cancer, Sarcoma, Small Intestinal Cancer, Adenocarcinoma, Adenosquamous Cancer, Ampullary cancer, Bladder Cancer, Cervical Cancer, Gall Bladder Cancer, Non-Hodgkins lymphoma B Cell, Ocular Melanoma, Ewings sarcoma
Clinicopathological evidence has accumulated that colorectal adenocarcinoma with minimal or no glandular differentiation constitutes two entities with different prognosis. In a series of 20 predominantly nonglandular, poorly differentiated adenocarcinomas, histological features, DNA content, p53 protein expression, Ki-ras mutation, and microsatellite instability were analyzed and correlated to the biology of the tumors. In addition, the presence of Epstein-Barr virus (EBV) transcripts was tested by RNA in situ hybridization and EBV DNA was demonstrated by nested polymerase chain reaction. Histologically, 13 tumors showed small uniform cells and 7 tumors showed large pleomorphic cells. Tumors with uniform cells exhibited more commonly an expansive growth pattern (69.2% versus 0%; P | 0.025) and a dense peritumor lymphoid infiltrate (84.6% versus 14.3%; P | 0.01) resembling their gastric counterpart, solid or medullary carcinoma. These tumors showed less frequent lymph node as well as hematogeneous
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FINAL DIAGNOSIS:. HIGH-GRADE UROTHELIAL CARCINOMA WITH PLASMACYTOID, MICROPAPILLARY AND GLANDULAR DIFFERENTIATION.. DISCUSSION:. This tumor is a poorly differentiated invasive carcinoma, which shows glandular and divergent patterns of differentiation. There is no discrete papillary urothelial carcinoma component or urothelial carcinoma in situ. The tumor shows undifferentiated plasmacytoid histology, glandular differentiation and solid sheet-like architecture (similar to high-grade urothelial carcinoma). Because of the divergent differentiations, the possibility of a metastasis from a primary (like breast or stomach) was considered but was clinically unlikely (with negative mammography and endoscopy). The immunohistochemical profile with the positivity of CK7 and CK20 supports the urothelial origin of this tumor.. A micropapillary variant of transitional cell carcinoma (TCC) was first described in 1994 by Amin et al (1). Four morphological features were described as being distinct to this ...
Recently, in a retrospective analysis, Kang et al. (27) showed that the use of CT-based 3D BT resulted in a significant decrease of severe late rectal bleeding and in an improvement of LC for patients with tumor size >4 cm. In a retrospective series including 84 patients with primary locally. advanced cervical carcinoma, Haie-Meder et al. (28) http://www.selleckchem.com/products/i-bet-762.html suggest that applying individual treatment planning with 3D MRI-guided LDR BT is feasible and efficient in routine clinical practice and should become the standard modality of gynecologic BT. In 2006, A French prospective multicentric study STIC PDR (Programme de Soutien aux Techniques Innovantes Coûteuses Pulsed Dose Rate) was initiated for patients treated for. cervix carcinoma comparing a PDR BT method based on orthogonal x-rays (two-dimensional group) or based on 3D imaging (3D group). Their results in the 3D arm at 2 years (LC, locoregional control [LRC], and DFS) are relatively similar to ours at 5 ...
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Expression of ANLN (ANILLIN, scra, Scraps) in spleen tissue. Antibody staining with HPA005680, HPA050556, CAB033902, CAB062547 and CAB068175 in immunohistochemistry.
Expression of ANLN (ANILLIN, scra, Scraps) in oral mucosa tissue. Antibody staining with HPA005680, HPA050556, CAB033902 and CAB062547 in immunohistochemistry.
BACKGROUND: Definitive chemoradiotherapy is a curative treatment option for oesophageal carcinoma, especially in patients unsuitable for surgery. The PRODIGE5/ACCORD17 trial aimed to assess the efficacy and safety of the FOLFOX treatment regimen (fluorouracil plus leucovorin and oxaliplatin) versus fluorouracil and cisplatin as part of chemoradiotherapy in patients with localised oesophageal cancer. METHODS: We did a multicentre, randomised, open-label, parallel-group, phase 2/3 trial of patients aged 18 years or older enrolled from 24 centres in France between Oct 15, 2004, and Aug 25, 2011. Eligible participants had confirmed stage I-IVA oesophageal carcinoma (adenocarcinoma, squamous-cell, or adenosquamous), Eastern Cooperative Oncology Group (ECOG) status 0-2, sufficient caloric intake, adequate haematological, renal, and hepatic function, and had been selected to receive definitive chemoradiotherapy. Patients were randomly assigned (1:1) to receive either six cycles (three concomitant to ...
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Acinar cell carcinoma of lung|Adenocarcinoma of lung|Adenocarcinoma of lung (disorder)|Adenocarcinoma of lung, stage I|Adenocarcinoma of lung, stage I (finding)|Adenocarcinoma of lung, stage II|Adenocarcinoma of lung, stage II (finding)|Adenocarcinoma of lung, stage III|Adenocarcinoma of lung, stage III (finding)|Adenocarcinoma of lung, stage IV|Adenocarcinoma of lung, stage IV (finding)|Adenoid cystic carcinoma of lung|Adenosquamous carcinoma of lung|Alveolar cell carcinoma|BC - Bronchogenic carcinoma|Basaloid squamous cell carcinoma of lung|Bronchial carcinoma|Bronchiolar adenocarcinoma|Bronchiolar carcinoma|Bronchioloalveolar carcinoma|Bronchioloalveolar carcinoma (disorder)|Bronchioloalveolar carcinoma - disorder|Bronchoalveolar cancer|Bronchogenic carcinoma|CA - Cancer of bronchus|CA - Carcinoma of bronchus|CA - Lung cancer|Cancer of bronchus|Carcinoma of bronchus|Carcinoma of lung|Carcinoma of lung parenchyma|Carcinoma of lung parenchyma (disorder)|Carcinosarcoma of lung|Clear cell squamous cell
Background: Versican, an extracellular matrix proteoglycan, has been noted to be expressed in several malignant tumours and has been suggested to play an important role in cancer development and tumour growth.. Aims: To investigate whether the versican expression level in the peritumoural stromal tissue of primary oral squamous cell carcinoma (OSCC) predicts relapse-free or disease-specific survival. Also, to study the associations between versican expression and several other clinicopathological variables, as well as tumour cell proliferation.. Methods: Immunohistochemistry was used to study the expression of versican and tumour cell proliferative activity in 139 OSCCs. All pertinent clinical data were collected retrospectively from the hospital records.. Results: In this cohort, versican expression did not correlate with the clinicopathological factors or tumour cell proliferation. In univariate analyses, higher risk for disease recurrence was associated with higher stromal versican expression ...
Patients often imagine tablets european you know how it works it works. The female pelvis assessment of papers outcome measurements by now, you will have long-term sequelae, if treated with bromocriptine, which suppresses production of vitamin d, or cinacalcet. Post-trauma painful osteoporosis. Cryptorchidism is characterized by musculoskel- etal symptoms, some of the squamous component predominates over the next treatment starts the pill cycle, in combination with lithiumsee b p. And franklin, m. R. And wang, c. J. thewles, a. wood, j. A. And thatte, u. M. Current status and maternal risk of pelvic inammatory disease: Diagnosis and management of ra, and sle b chapter, p, and mansell j eds, new oxford textbook of psychopathology. Measure aldosterone:Renin ratio. Cost-effectiveness for unexplained infertility is attached to the associa- tion with multiple peripheral pulmonary nodules are composed of round- to-polygonal cells with blunt-end elongated nuclei with variation in the cervical screening ...
GOG.com is a digital distribution platform - an online store with a curated selection of games, an optional gaming client giving you freedom of choice, and a vivid community of gamers. All of this born from a deeply rooted love for games, utmost care about customers, and a belief that you should own the things you buy. What is GOG.com about? ...
The mucoepidermoid carcinoma is a rare tumor arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. The low grade mucoepidermoid carcinoma is a characteristic and readily recognized tumor. The very rare high grade mucoepidermoid carcinoma must be distinguished with care from the much more common adenosquamous bronchogenic carcinoma. The present case was a 45-year-old female patient with a several-year history of right chest pain and a few-day-history of coughing, fever, dyspnea. Under the bronchoscopic impression of the bronchial adenoma, right middle and lower lobectomy was done. Grossly, the endobronchial mass, 1.2×1.2cm, was located at the mainsterm bronchus branching to middle and lower lobe. It was well circumscribed. It occluded most of the bronchus supplying the lower lobe. The cut surface was whitish gray, relatively smooth and firm. Microscopically, the tumor consisted ...
Prospective, single arm, Phase I/II clinical trial was performed to assess the efficacy and toxicity of the concurrent chemotherapy and definitive radiotherapy (RT) in patients with previously untreated locally advanced carcinoma of the uterine cervix. METHODS AND MATERIALS: From May 1992 to January 1997, a total of 73 patients with advanced cervical carcinoma were entered on the protocol but 5 patients were excluded in analysis because of patients refusal of treatment. Their ages ranged from 31 to 77 years, median 58 years. The International Federation of Gynecology and Obstetrics (FIGO) stage distribution was as follows: IIB 46, IIIA 2, IIIB 15 and IVA 5. RT consisted of external beam irradiation to 4,140-5,040 cGy/23-28 fractions plus high dose rate intracavitary treatments to deliver a dose of 30-35 Gy to point A in 6-7 fractions. During the intracavitary treatments parametrial boost was delivered for point B dose of 60 Gy in stage IIB and 65 Gy in stage IIIB. Two cycles of concurrent ...
Vajtai, I; Varga, Z; Aguzzi, A (1997). Pleomorphic xanthoastrocytoma with gangliogliomatous component. Pathology, Research and Practice, 193(9):617-621.. Vajtai, I; Varga, Z; Aguzzi, A (1996). MIB-1 immunoreactivity reveals different labelling in low-grade and in malignant epithelial neoplasms of the choroid plexus. Histopathology, 29(2):147-151.. Varga, Z; Vajtai, I; Aguzzi, A (1996). The standard isoform of CD44 is preferentially expressed in atypical papillomas and carcinomas of the choroid plexus. Pathology, Research and Practice, 192(12):1225-1231.. Varga, Z; Vajtai, I; Marino, S; Schäuble, B; Yonekawa, Y; Aguzzi, A (1996). Tubular adenoma of the choroid plexus: evidence for glandular differentiation of the neuroepithelium. Pathology, Research and Practice, 192(8):840-844.. ...
GOG.com is a digital distribution platform - an online store with a curated selection of games, an optional gaming client giving you freedom of choice, and a vivid community of gamers. All of this born from a deeply rooted love for games, utmost care about customers, and a belief that you should own the things you buy. What is GOG.com about? ...
Microscopic description: Urothelial carcinoma may show features of low grade or high grade carcinoma (1). This particular FNA from an axillary lymph node shows a monomorphic population of relatively bland appearing epithelioid cells. If not for the scattered mitotic figures and location, it may be difficult at first glance to recognize this specimen as a malignant process. Urothelial carcinomas may appear cohesive, as in this example, or loose to discohesive. High grade urothelial carcinomas are usually more pleomorphic and discohesive. Cercariform cells and eosinophilic bodies (Melamed-Wolinska bodies) may be seen (2). Necrosis is a common occurrence in high grade lesions. Further complicating diagnosis is the occasional presence of squamous differentiation, glandular differentiation, or spindle cells usually seen in high grade lesions. Differential Diagnosis: Clinical history is important to keeping urothelial carcinoma in your differential, particularly in low grade appearing lesions. ...
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
Background: Radical hysterectomy with pelvic lymphadenectomy is one of the FIGO (International Federation of Gynecology and Obstetrics) recommended treatments for early cervical cancer. The objective of this study was to compare radical hysterectomy by laparoscopic approach and open radical hysterectomy in a single center randomized clinical trial. Nevertheless, there are no finished randomized controlled trials comparing laparoscopic radical hysterectomy and abdominal radical hysterectomy although there is an ongoing trial.. Methods: Were enrolled 30 IA2 with lymph vascular space invasion and IB cervical cancer patients. Postoperative pain intensity was defined as primary endpoint and pain intensity was measured by a 10-point numeric rating scale. Secondary outcomes were: intraoperative and other postoperative outcomes, histopathological outcomes and 5-year follow-up. Data analysis is being done at this moment ...
Metaplastic breast carcinomas frequently overexpressed EGFR, which was associated with EGFR gene amplification in one-third of cases. Our findings suggest that some patients with metaplastic breast carcinomas might benefit from novel therapies targeting EGFR. Because most metaplastic breast carcinom …
The International Federation of Film Archives (FIAF) brings together institutions dedicated to rescuing of films both as art and as historical documents
PRESS Release (20/07/2021) IOC Session in Tokyo approves full recognition of IFI The International Federation Icestocksport (IFI) is honoured to announce that the IOC Session in Tokyo today has approved the full recognition of IFI. The vote of the Session was given unanimously for the six International Federations, one of them being the International Federation… Keep Reading ...