TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference ( ...
Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period.. In prospectively performed clinical trials, objective responses to any cytotoxic agent or regimen are infrequent, whereas stabilization of disease was observed more commonly.. In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare.. According to Younes MN et als study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. And when treated with EGFR/VEGFR TK dual inhibitor, the phosphorylated form of Akt decreased despite of total level of Akt is remained unchanged.. When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an ...
Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC). This study aims to decipher the prognostic and mechanistic role of PIM1 in progression of SACC cells and tumor tissues. A SACC cell line (ACC-M) was transfected with shRNA plasmids targeting the PIM1 gene. The expression levels of PIM1, RUNX3 and p21 were measured by quantitative real-time PCR and western blot. Subcellular translocalization of RUNX3 and p21 proteins was assessed using immunofluorescence, and cell cycle phase was quantified using flow cytometry. A total of 97 SACC patients were retrospectively analyzed by clinicopathologic characteristics and survival outcomes. After down-regulation of PIM1 in ACC-M cells, RUNX3 and p21 proteins were translocated from cytoplasm to nucleus, with a decrease of p21 expression and increase of G0/G1 phase cells. PIM1 and RUNX3 levels show a distinct
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic ...
Salivary adenoid cystic carcinoma (SACC) is one of the most frequent carcinomas derived from the salivary gland. Growing evidence implied the involvement of microRNAs (miRNAs) in SACC progression and metastasis. This study aimed to determine the regulatory role of miR-140-5p in SACC progression and metastasis and to explore the underlying mechanisms. MiR-140-5p and survivin mRNA expression levels were determined by quantitative real-time PCR; protein levels were evaluated by western blot assay; cell proliferation, growth, invasion, apoptosis and caspase-3 activity were evaluated by respective in vitro functional assays; xenograft nude mice model was used to assess the in vivo tumor growth; a luciferase reporter assay determined the interaction between miR-140-5p and survivin. MiR-140-5p overexpression suppressed SACC cell proliferation and invasion, induced cell apoptosis and inhibited in vivo tumor growth of SACC cells. The loss-of-function studies showed that miR-140-5p knockdown enhanced SACC cell
In a single-center phase II study reported in the Journal of Clinical Oncology, Tchekmedyian et al found that the multitargeted tyrosine kinase inhibitor lenvatinib was active in progressive recurrent or metastatic adenoid cystic carcinoma.. Study Details. In the study, 32 evaluable patients at Memorial Sloan Kettering Cancer Center with recurrent or metastatic adenoid cystic carcinoma of any primary site and radiographic or symptomatic progression were treated with lenvatinib 24 mg orally per day. Any prior therapy except lenvatinib was allowed.. The primary endpoint was overall response rate. The study was to be considered positive if 4 or more responses occurred among a total of 32 patients. Overall, 78% of patients had adenoid cystic carcinoma of either the major or minor salivary glands, and 96.9% had distant metastases.. Responses. Five patients (15.6%) had confirmed objective response (all partial responses) and an additional 24 patients (75.0%) had stable disease. Median progression-free ...
Treatment with novel radiotherapeutic technologies could increase local control in adenoid cystic carcinoma of the head and neck. Especially combined treatment with intensity-modulated radiation therapy and heavy ion (C12) boost to the primary tumor or previous tumor bed could be established as the treatment of choice in this disease.. Unfortunately, therapeutic results in the treatment of adenoid cystic carcinoma are still hampered by the occurrence of distant metastases (predominantly in the lungs) which, though progressing comparatively slowly, still limit the patients life expectancy. Most adenoid cystic carcinomas (, 80%) though, exhibit over-expression of EGFR receptors and hence provide an approach for systemic treatment. In this prospective phase II trial, the application of the EGFR antibody cetuximab will be evaluated in combination with the established treatment of intensity-modulated radiation therapy plus C12 heavy ion boost.. The trial aims at evaluation of toxicity and ...
Adenoid cystic carcinoma is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In a brief report published on 17 June 2013 in theJournal of Clinical Investigation, researchers led by Andrew Futreal of the Cancer Genome Project, Wellcome Trust Sanger Institute in Cambridge, United Kingdom, reported on a whole exome sequencing performed in 24 adenoid cystic carcinoma cases.. They uncovered the involvement of multiple cancer genes that are likely to be contributing to tumour development in the context of MYB activation. The data point to disruption of chromatin regulation as a major factor in adenoid cystic carcinoma development. Furthermore, the data implicate NOTCH signalling deregulation in a proportion of cases. Finally, the analysis has identified activating mutations of the receptor tyrosine kinase FGFR2 in ...
Rare type of cancer Adenoid cystic carcinoma symptoms causes and treatment एक रिपोर्ट के मुताबिक, हर साल कैंसर के पांच लाख मामलों में करीब 1200 मामले अडेनाइड सिस्टिक कार्सिनोमा के होते हैं। Read latest hindi news (ताजा हिन्दी समाचार) on rare type of cancer, adenoid cystic carcinoma, adenoid cystic carcinoma symptoms - #1 हिन्दी न्यूज़ website.
Free Online Library: Ceruminous gland adenoid cystic carcinoma with contralateral metastasis to the brain. by Archives of Pathology & Laboratory Medicine; Health, general Cancer metastasis Diagnosis Head and neck cancer Metastasis
TY - JOUR. T1 - Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. AU - Yamamoto, Yuzo. AU - Virmani, Arvind K.. AU - Wistuba, Ignacio I.. AU - McIntire, Donald. AU - Vuitch, Frank. AU - Albores-Saavedra, Jorge. AU - Gazdar, Adi F.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the p53 and RB genes and low or absent K-ras mutations and LOH at chromosomal loci 3p, 5q, 8p, and 9p. From 21 tumors, the authors carefully microdissected and analyzed 36 subtype foci. Three interrelated pieces of evidence indicate that the relatively poor ...
TY - JOUR. T1 - AKT3 drives adenoid cystic carcinoma development in salivary glands. AU - Zboray, Katalin. AU - Mohrherr, Julian. AU - Stiedl, Patricia. AU - Pranz, Klemens. AU - Wandruszka, Laura. AU - Grabner, Beatrice. AU - Eferl, Robert. AU - Moriggl, Richard. AU - Stoiber, Dagmar. AU - Sakamoto, Kazuhito. AU - Wagner, Kay Uwe. AU - Popper, Helmut. AU - Casanova, Emilio. AU - Moll, Herwig P.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic ...
Adenoid cystic carcinoma is a malignant tumour frequently described arising from seromucinous salivary tissue in the major and minor salivary glands. Within the nasal cavity, it is uncommon and usually involves the lateral wall. A rare case of adenoid cystic carcinoma of the nasal septum is presented along with a review of the literature. The presentation and management of this uncommon condition is discussed. ...
Background: Primary external auditory canal (EAC) malignancies are very rare with adenoid cystic carcinoma (ACC) representing approximately 5% of these tumors. There is insufficient knowledge of the natural behavior of ACC in EAC. The disease needs early detection and complete treatment because of its tendency to recur, vicinity to sensitive organs and lower response to radiation.. Case presentation: In this case study, we presented a case of young female (37 years old) with right external auditory canal (EAC) mass which was diagnosed as a benign tumor, a postoperative biopsy confirmed it as ACC of the EAC which is a rare case in the literature.. Conclusion: Here, we report a rare case of Adenoid Cystic Carcinoma (ACC) of External Auditory Canal (EAC) in a 37 years old Saudi female. Initial, Clinical and CT findings were suggestive of a benign cystic mass but histopathology examination confirmed that tumor was ACC of EAC. The patient underwent to radical excision of the tumor along the complete ...
Kimberly Smith admired her brother-in-law for his kindness and thoughtfulness, as well as his courageous fight with stage IV adenoid cystic carcinoma (ACC), a rare cancer, when he was only 26 and newly married. In his honor, the family established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research at MD Anderson.
Adenoid cystic carcinomas are a rare histological subtype of adenocarcinoma. Pathology Adenoid cystic carcinomas are generally considered low grade 4. The tumours have a notable tendency for perineural spread. Location They have a wide distri...
Adenoid cystic carcinoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
15. NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway SCOPUS SCIE 作者:Gao, Xiao-lei; Zheng, Min; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Li, Li; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Tang, Ya-Jie; Liang, Xin-hua; Tang, Ya-ling. 作者机构:[Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Zheng, Min; Li, Li] Wenzhou Med Univ, Zhoushan Hosp, Dept ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of hybrid carcinomas that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Adenoid Cystic Carcinoma: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of MYB gene rearrangements and MYB-NFIB chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. MYB and TLN2 were affected by somatic mutations in two
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
PURPOSE: To study the effect of hepatitis B virus X protein binding protein (HBXIP) on proliferation, migration and invasion of adenoid cystic carcinoma cell line ACC-M, and the possible mechanism of PI3K/Akt signaling pathway. METHODS: HBXIP plasmid was transfected into ACC-M. The cells were divided into experimental group (transfected with plasmid pEGFP-N1-HBXIP) control group (non-transfected group) and blank control group (vector group, pEGFP-N1). RT-PCR was used to detect the expression HBXIP in ACC-M; MTT assay, transwell chamber experiments and scratches over the proliferation of HBXIP were utilized individually to evaluate the influence of HBXIP on ACC-M expression, migration and invasion; Western blotting was used to detect the protein expression of Akt, p-Akt, PI3K, p-PI3K and S100A4 after overexpression of HBXIP ...
Li, N., Xu, L., Zhao, H., El-Naggar, A. K. and Sturgis, E. M. (2012), A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer, 118: 3945-3953. doi: 10.1002/cncr.26740 ...
Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals. Controversy exists as to the benefit of regularly following asymptomatic patients to look for distant metastases because even if one is found, the options for further management are limited. When a metastasis is limited to the lung in an asymptomatic patient with no locoregional recurrence, metastasectomy might provide some long-term benefit, although we cannot know for certain. We encountered such a case, and we opted for surgical resection rather than a conservative approach. There is a need for multicenter trials so that the management of such patients, be it active or conservative, can be evidence-based.. ...
Adenoid cystic carcinoma (ACC) is a relatively rare form of cancer that most commonly develops in the salivary glands or other regions of the head and neck.
A Phase 2, Open-Label, Multi-centre Study of AL101 in Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at di …
Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer. Epidemiology They account for only 0.1-0.4% of all breast cancers. Pathology The tumour demonstrates a strikingly characteristic microscopic pattern similar to t...
目的:探讨外耳道腺样囊性癌的临床及病理特点,以提高诊断和治疗水平。方法:回顾性分析1例外耳道腺样囊性癌患者自首诊8年来连续的临床表现,病程进展,治疗及随访结果。结果:患者术后随访半年无复发。结论:外耳道腺样囊性癌生长缓慢,可长期带瘤生存但远期预后不佳,首次治疗应该采用扩大根治性手术,术后结合临床病理分期辅以放射治疗以提高治愈率。 Objective: To detect the clinical and pathological features of the adenoid cystic carcinoma of external audi-tory canal, and to improve its diagnosis and treatment level. Method: A retrospective analysis has been performed on patients with ACCEAC by their clinical manifestation, the therapy and follow-up results since 8 years ago as well as the combination with there view of related literature. Result: Patients without recurrence of postoperative follow-up of six months. Conclusion: Adenoid cystic carcinoma of external
Adenoid cystic carcinoma of nasopharynx: a single-center retrospective study, Shujun Ding, Tongai Jin, Min Xu, Yong Liang, Shoufeng Wang, Lingyun Lv, De Huai
The aim of this study was to determine the proteome of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature...
This is Cancer.Nets Guide to Adenoid Cystic Carcinoma. Use the menu below to choose the Introduction section to get started. Or, you can choose another section to learn more about a specific question you have. Each guide is reviewed by experts on the Cancer.Net Editorial Board, which is composed of medical, surgical, radiation, gynecologic, and pediatric oncologists, oncology nurses, physician assistants, social workers, and patient advocates.. ...
TY - JOUR. T1 - The mutational landscape of adenoid cystic carcinoma. AU - Ho, A.S.. AU - Kannan, K.. AU - Roy, D.M.. AU - Morris, L.G.T.. AU - Ganly, I.. AU - Katabi, N.. AU - Ramaswami, D.. AU - Walsh, L.A.. AU - Eng, S.. AU - Huse, J.T.. AU - Zhang, J.N.. AU - Dolgalev, I.. AU - Huberman, K.. AU - Heguy, A.. AU - Viale, A.. AU - Drobnjak, M.. AU - Leversha, M.A.. AU - Rice, C.E.. AU - Singh, B.. AU - Iyer, N.G.. AU - Leemans, C.R.. AU - Bloemena, E.. AU - Ferris, R.L.. AU - Seethala, R.R.. AU - Gross, B.E.. AU - Liang, Y.P.. AU - Sinha, R.. AU - Peng, L.K.. AU - Raphael, B.J.. AU - Turcan, S.. AU - Gong, Y.X.. AU - Schultz, N.. AU - Kim, S.. AU - Chiosea, S.. AU - Shah, JP. AU - Sander, C. AU - Lee, W.. AU - Chan, T.A.. PY - 2013. Y1 - 2013. U2 - 10.1038/ng.2643. DO - 10.1038/ng.2643. M3 - Article. VL - 45. SP - 791. EP - 798. JO - Nature Genetics. JF - Nature Genetics. SN - 1061-4036. IS - 7. ER - ...
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis Chunliu Ning,1 Tengfei Zhao,1 Zechen Wang,1 Delong Li,1 Yurong Kou,2 Shaohui Huang1 1Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China Background: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. Materials and methods: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3.
Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck This study is currently recruiting participants. Verified March 2012 by University of Iowa…
Background: Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are uncommon in the uterine cervix. .001). Conclusions: Even though the nuclei of both these buy 253863-00-2 tumor types had been oval formed, inferred through the ratio of small axis to main axis (0.728 in ACC and 0.669 in ABC), the region of nuclei was 1 approximately.7 times bigger in ACC than in ABC. Distinguishing nucleic features, including region, morphology, and chromatin design, may be useful in making the correct analysis. Keywords: Adenoid cystic carcinoma, Adenoid basal carcinoma, Genital smears, Papanicolaou check The World Wellness Firm (WHO) classifies malignant tumors from the uterine cervix into three classes: squamous tumors, glandular tumors, and additional epithelial tumors [1]. The group of additional epithelial tumors comprises five different tumor types: adenosquamous carcinoma, adenoid cystic carcinoma (ACC), adenoid basal carcinoma (ABC), neuroendocrine tumors, and undifferentiated carcinoma ...
Discover natural remedies to help in the treatment of adenoid cystic carcinoma, such as acupuncture, hydrogen peroxide therapy and Vitamin B-17.
Background:. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrated that Pim-1 phosphorylates RUNX3 and alters its subcellular localization. As a highly malignant tumor, salivary adenoid cystic carcinoma (ACC) accounts for approximately 10% of all epithelial salivary tumors and the 5-year survival rate of patients with highly metastatic ACC is less than 20%. However, few studies have concerned the implications of Pim-1 in the salivary ACC.. Aim:. In this study, we aimed to clarify the function of Pim-1 in ACC cell lines in vitro. Meanwhile, we measure the levels of Pim-1 and RUNX3 in the ACC tissues. The correlations between Pim-1/RUNX3 levels and clinical parameters were also analyzed. Methods:. SACC-83 and SACC-LM cells were transfected with the Pim-1 siRNA. Pim-1 mRNA and protein expression were measured using real-time PCR and immnuoblot, ...
Tumors of the lacrimal gland constitute less than 5% of all biopsied orbital lesions [3, 4]. The most common epithelial malignancy is primary adenoid cystic carcinoma; adenocarcinoma is rare, representing only 5 to 7% of epithelial tumors of the lacrimal gland [2-6]. Because there is no specific histopathologic classification for lacrimal gland tumors, they are often classified according to the histological classification of salivary gland tumors with which they share many similarities [1, 3, 7].. This subtype of lacrimal gland, adenocarcinoma, was described for the first time in 1996 by Katz et al. [2]. Since then, most reports in the literature are case reports describing an aggressive clinical pattern and poor prognosis [1, 2, 8].. The tumor usually begins in the upper eyelid as a growth and is accompanied by clinical symptoms such as lid pseudoptosis, exophthalmos, dystopia, pain, and reduced visual acuity [4, 6].. The patients short life expectancy after surgical treatment for ...
TY - JOUR. T1 - Genetic profiling of patients with adenoid cystic carcinoma of the Bartholins glands reveals potential new routes for targeted therapies. T2 - A case report. AU - Nakamura, Kohei. AU - Aimono, Eriko. AU - Tanishima, Shigeki. AU - Nomura, Hidetaka. AU - Imai, Mitsuho. AU - Hayashi, Hideyuki. AU - Nishihara, Hiroshi. N1 - Funding Information: This study was supported by JSPS KAKENHI (Grant-in-Aid for Young Scientists B) grant 20 K18232, and Japan Agency for Medical Research and Development (AMED) grant JP 16kk0205006. AMED had no control over the interpretation, writing, or publication of this work. Publisher Copyright: © 2020 The Author(s).. PY - 2020/5/28. Y1 - 2020/5/28. N2 - Background: Bartholin gland carcinomas (BGCs) are rare tumor types, for which no molecular analyses including genomic sequencing have been reported to date. Adenoid cystic carcinomas (ACCs) of the Bartholins glands are an atypical histological type of BGC, and currently nothing is known regarding their ...
Adenoid Cystic Carcinoma, Minor Salivary Gland Cancer is back/Recurred Oh No Gabbymom04 - WhatNext.com - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
Choroidal metastasis rarely reveals a primary cancer. At this stage, they are associated with multiple metastases. Adenoid cystic carcinoma also known..
Blake , PW, Toro , JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat. vol. 30. 2009. pp. 1025-36. (A comprehensive review about the clinical features, molecular genetics, and the animal models of Brooke-Spiegler syndrome.). Layegh , P, Sharifi-Sistani , N, Abadian , M, Moghiman , T. Brooke-Spiegler syndrome. Indian J Dermatol Venereol Leprol. vol. 74. 2008. pp. 632-4. (A case report describing a patient diagnosed as Brooke-Spiegler syndrome.). Kazakov , DV, Zelger , B, Rütten , A, Vazmitel , M, Spagnolo , DV, Kacerovska , D. Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol. vol. 33. 2009. pp. 705-19. (An article describing a series of 24 malignant neoplasms arising in preexisting benign spiradenoma ...
Learn about salivary gland cancer treatment advances. New radiation therapy technology has resulted in improved treatment of salivary gland cancer.
Treatments for salivary gland cancer include surgery and radiation. Learn about treatment plans and options for salivary gland cancer.
Primary malignant neoplasms of trachea and tracheal invasion by thyroid malignancies although rare are serious causes of morbidity and mortality. Management of tracheal tumours in general includes interventional endoscopy, surgery and radiotherapy. This paper describes the surgical and functional results of tracheal resections done in the surgical oncology department of a tertiary care cancer centre. Methods: This is a retrospective analysis of all patients with malignant tracheal tumours who underwent resection and anastomosis in the period 2005-2009. Nine consecutive patients with tracheal involvement either from locally invasive thyroid malignancy or from primary tracheal adenoid cystic carcinoma were included in the study. Results: Six patients had locally invasive differentiated thyroid cancer and three had adenoid cystic carcinoma. The male to female ratio was 2:1. All thyroid cases were papillary carcinoma with involvement of tracheal lumen. These patients underwent thyroidectomy along ...
TY - JOUR. T1 - Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma. T2 - A phase II trial. AU - Hitre, E.. AU - Budai, B.. AU - Takácsi-Nagy, Z.. AU - Rubovszky, G.. AU - Tóth, E.. AU - Remenár, É. AU - Polgár, C.. AU - Láng, I.. PY - 2013/9. Y1 - 2013/9. N2 - Background:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated.Methods:Eligible patients (9 with locally advanced tumour and 12 with metastases) had positive tumour EGFR expression. The cetuximab loading dose (400 mg m -2) was followed by 250 mg m -2 per week. Locally advanced tumours were irradiated (mean dose 65 Gy) and treated with concomitant cisplatin (75 mg m -2, intravenously). Patients with metastases received ...
David Height - Born in Riga, Latvia but lived in Milwaukee, WI since age of 16. Born: 1923. Diagnosed with ACC: 1957. Died from ACC: 1970. ...
Multiple familial trichoepithelioma (also known as Brooke-Spiegler syndrome and epithelioma adenoides cysticum) is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face. The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene. Types include: Brooke-Spiegler syndrome is a condition where multiple skin tumors develop from skin structures. Tumors commonly occurring in this syndrome include spiradenomas, trichoepitheliomas, and cylindromas. The tumors are generally benign, but may become malignant. Affected individuals are also at increased risk of developing tumors in tissues other than skin - particularly benign or malignant tumors of the salivary glands. Tumours in Brooke-Spiegler typically appear in early adulthood ...
ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Nets Guide to Salivary Gland Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.About the salivary glandsThe salivary glands contain tissues that produce saliva. Saliva is important to the
Most people with salivary gland cancer will have radiation therapy, alone or with other treatments. Learn about radiation therapy for salivary tumours.
Layne Compston wasnt born yet when his mother was diagnosed with throat cancer as a teenager. But hes learned a lot from hearing about that experience and watching her deal with salivary gland cancer more recently.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Information on salivary gland cancer, including how it is diagnosed, treatments you might have, possible side effects and how to get further support.
As many readers of this blog will know, I have cancer. Ive had many operations over the last fifteen years, but a few years ago we decided that the spread was now wide enough that further surgery was not very pointful; we should instead wait for particular lesions to start causing problems, and only then treat them. (I have metastases in my lungs, liver, remaining kidney, leg, pleura and other places.). Historically, chemotherapy hasnt been an option for me. Broad spectrum chemotherapies work by killing anything growing fast; but my rather unusual cancer doesnt grow fast (which is why Ive lived as long as I have so far) and so they would kill me as quickly as they would kill it. And there are no targetted drugs for Adenoid Cystic Carcinoma, the rare salivary gland cancer I have.. However, recently my oncologist referred me to The Christie hospital in Manchester, which is doing some interesting research on cancer genetics. With them, Im trying a few things, but the most immediate is that ...
The genetic predisposition to these tumours is rare. Although cylindromas carry a significant burden of disease, they are usually not life threatening, which may explain why there are few studies looking at the benefits of genetic testing in affected or at risk individuals. Anecdotal evidence is described in one study of 26 affected patients.2 In this study, issues relating to genetic counselling which are relevant to those undergoing genetic testing for CYLD mutations are explored. When a pathogenic mutation in CYLD is identified in a patient who meets the criteria for testing, they have the advantage of knowing their diagnosis is confirmed, and can use the information for their benefit. Patients who present with multiple skin appendage tumours but are not known to have a family history may not have considered that their tumours could represent an underlying genetic cause. The knowledge that this is so can help them anticipate the fact that further tumours may develop and prepare for necessary ...
Brooke-Spiegler Syndrome. Quyn Sherrod, MD; Miguel Gutierrez, MD; Keith Carlson, MD UCLA/WLA VA Division of Dermatology David Geffen School of Medicine Los Angeles, California. History. 39 year-old, healthy, Caucasian male Multiple lesions on face and scalp beginning at 10 years old...
Examples adenoid cystic carcinoma cribriform adenocarcinoma of minor salivary glands polymorphous adenocarcinoma pleomorphic adenoma (...)
The epidemiology, pathology, clinical presentation, treatment, and prognosis of malignant primary tracheal tumors will be reviewed here.Depending upon histology and location, tracheal tumors may overlap with primary lung cancers or head and neck lesi
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug ...
Head and Neck Cancer is a term used to describe a number of different malignant tumours that develop in or around the throat, larynx, nose, sinuses, and mouth.. Most Head and Neck Cancers are Squamous Cell Carcinomas. This type of cancer begins in the flat, squamous cells that make up the thin layer of tissue on the surface of the structures in the head and neck. Directly beneath this lining, which is called the epithelium, some areas of the head and neck have a layer of moist tissue, called the mucosa. If a cancer is limited to the squamous layer of cells, it is called Carcinoma in Situ. If the cancer has grown beyond this cell layer and moved into the deeper tissue, then it is called Invasive Squamous Cell Carcinoma.. If a Head and Neck Cancer starts in the salivary glands, the tumour will usually be classified as an adenocarcinoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma. ...
Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor
All of the tumors are infiltrative into the soft tissue, benign ceruminous glands, and/or bone. The tumor may expand into the overlying squamous surface epithelium, but it usually does not arise from the surface epithelium. The tumors are cellular, arranged in solid, cystic, cribriform, glandular, and single cell patterns. It is uncommon to see tumor necrosis, but when it is present, it is diagnostic of cancer. The same is true of perineural invasion. Nuclear pleomorphism is usually easily to identify, with the nuclei containing prominent nucleoli. There are usually increased mitotic figures, including atypical forms. There are usually areas of stromal fibrosis. Ceroid (cerumen or ear wax) is not seen in malignancies, although it is seen in benign tumors. The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types.[3]. ...
Familial Cylindromatosis (Turban Tumor Syndrome): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Neutron therapy is a form of radiotherapy used by radiation oncologists to treat certain types of tumour. Neutrons are sub-atomic particles with different radiobiological properties from photons and protons but similar to carbon ions. Neutrons are used in the treatment of salivary gland (adenoid cystic carcinomas), other head & neck tumours, sarcomas, prostate, breast cancer, mesothelioma, chordomas and rare cancers
Tumor markers are substances found in the blood, urine or body tissues that can be elevated in cancer. There are many different tumor markers. They are used in oncology to help determine the presence of cancer. An elevated level of a tumor marker can indicate cancer, however there can often also be other causes of the elevation.. Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. Tumor markers can be used in screening programs, such as screening for elevated levels of prostate specific antigen (PSA) to indicate possible prostate cancer. Tumor markers are also used to monitor patients for cancer return. Tumor markers can be classified in two groups: Cancer-specific markers and tissue-specific markers.. Adenoid Cystic Carcinoma. Ki- ...
and a 1.6-inch area in the left uterine area that needs to be checked for possible pelvic cancer.. The good news? There is no sign of disease elsewhere, including in my head, lungs, heart and other organs. Yippee! Seriously.. Life can turn on a dime, you know?. I reached for chocolate!. Did you all know Im claustrophobic? That makes all this scanning business quite stressful for me. An MRI is almost out of the question. Honestlly, part of me now believes the worst is over, if they dont make me get in another tube.. Heres the plan right now. Liver surgeon Dr. Qasim Chaudhry is sharing my report with the Tumor Board of consulting cancer physicians at Iowa Methodist, who know my internals very well by now. The discussion will probably include surgical removal of the tumors, since adenoid cystic carcinoma just doesnt have a history of responding to chemotherapy. If removal is the next step, this will be my third time having it done. First a golf-ball-sized tumor was removed from my lower ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the Cheeky Librarian, since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the Cheeky Librarian, since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
A 51-year-old white man was admitted to the Nemazee Hospital on June 1, 1957, with the chief complaint of difficulty in breathing.He was perfectly well until si
Oranje, A.P, Halley, D.J.J, den Hollander, J.C, Teepe, R.G.J, van de Graaf, R, van den Ouweland, A.M.W, & Wagner, A. (2008). Multiple familial trichoepithelioma and familial cylindroma: One cause!. Journal of the European Academy of Dermatology and Venereology, 22(11), 1395-1396. doi:10.1111/j.1468-3083.2008.02648. ...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
View details of top pituitary gland cancer hospitals in Navi Mumbai. Get guidance from medical experts to select best pituitary gland cancer hospital in Navi Mumbai