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TY - JOUR. T1 - Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. AU - Jäkel, Cornelia. AU - Bergmann, Frank. AU - Toth, Reka. AU - Assenov, Yassen. AU - Van Der Duin, Daniel. AU - Strobel, Oliver. AU - Hank, Thomas. AU - Klöppel, Günter. AU - Dorrell, Craig. AU - Grompe, Markus. AU - Moss, Joshua. AU - Dor, Yuval. AU - Schirmacher, Peter. AU - Plass, Christoph. AU - Popanda, Odilia. AU - Schmezer, Peter. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The ...
Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. It represents 5% of all exocrine tumours of the pancreas, making it the second most common type of pancreatic cancer. It is abbreviated ACC. It typically has a guarded prognosis. The disease is more common in men than women and the average age at diagnosis is about 60. Symptoms are often non-specific and include weight loss. A classic presentation, found in around 15% of cases includes subcutaneous nodules (due to fat necrosis) and arthralgias, caused by release of lipase. ACC are associated with increased serum lipase and manifest in the classic presentation as the Schmid triad (subcutaneous fat necrosis, polyarthritis, eosinophilia). ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. They can arise in any part of the pancreas. Histomorphologically, the tumour resembles the cells of the pancreatic acini and, ...
Since acinar cell carcinoma(ACC)of pancreas is rare, we sometimes meet a case hard to make diagnosis before surgery. We here reported a case of ACC of pancreas with extensive intraductal growth to the main pancreatic duct and the branch of the pancreatic duct. A 43-year-old man visit a clinic with a concern of uncomfortable feeling on left side abdomen. CT/MRI examination showed a ischemic tumor, 38×25 mm, in the body-tail of the pancreas, and the tumor infiltrated to left renal capsule. ERCP showed the interruption and stenosis of the pancreatic duct at the point adjacent to tumor. Cytological diagnosis of the pancreatic juice was performed, but malignant cells were not detected(Class III ). The tumor abnormally accumulated FDGin PET-CT examination(SUVmax 3.3). We diagnosed the tumor PDAC with infiltrating to the left renal capsule, and the distal pancreatectomy was performed. The pathological examination of the resected specimen showed that the tumor progressed into main pancreatic duct and ...
TY - JOUR. T1 - Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation. AU - Varsegi, Mary F.. AU - Ravis, Scott M.. AU - Hattab, Eyas M.. AU - Henley, John D.. AU - Billings, Steven D.. PY - 2008/6. Y1 - 2008/6. N2 - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease. To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.. AB - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a ...
Case Report: 59-year-old man was admitted with an infiltrative, solid lesion in pancreatic tail diagnosed as PACC. Lymph nodes in the hepatic hilum were enlarged, and many metastatic liver nodules were observed. After partial pancreatectomy, the left and right lobes of the liver were separately treated with Y-90 resin microspheres. Follow-up imaging revealed that all hepatic nodules shrank by at least 50%, and 3 nodules disappeared completely. Lipase concentration was 8407 U/L at baseline, rose to 12,705 U/L after pancreatectomy, and declined to 344 U/L after SIRT. Multiple rounds of chemotherapy in the subsequent year shrank the hepatic tumors further; disease then progressed, but a third line of chemotherapy shrank the tumors again, 16 months after SIRT treatment ...
Context Acinar cell carcinoma is rare disease of exocrine pancreas with an indolent course and favorable tumor biology. It usually occurs in elderly m..
Pancreatic panniculitis is a rare condition, which has only been described in relation with pancreatic diseases up to now. It is characterized by necrotizing subcutaneous inflammation and is thought to be triggered by adipocyte necrosis due to systemic release of pancreatic enzymes with consecutive infiltration of neutrophils. We present the first case of a patient with pancreatic panniculitis caused by pancreatic-type primary acinar cell carcinoma (ACC) of the liver and without underlying pancreatic disease. A 73-year old Caucasian female patient was referred to our department with painful cutaneous nodules persisting for eight weeks and with marked lipasemia (~15000 U/l; normal range |60 U/l). Four weeks prior, several liver lesions had been detected. Empiric treatment with steroids did not show any effect. A biopsy of the skin nodules revealed
Pancreatic panniculitis is a rare condition, which has only been described in relation with pancreatic diseases up to now. It is characterized by necrotizing subcutaneous inflammation and is thought to be triggered by adipocyte necrosis due to systemic release of pancreatic enzymes with consecutive infiltration of neutrophils. We present the first case of a patient with pancreatic panniculitis caused by pancreatic-type primary acinar cell carcinoma (ACC) of the liver and without underlying pancreatic disease. A 73-year old Caucasian female patient was referred to our department with painful cutaneous nodules persisting for eight weeks and with marked lipasemia (~15000 U/l; normal range |60 U/l). Four weeks prior, several liver lesions had been detected. Empiric treatment with steroids did not show any effect. A biopsy of the skin nodules revealed
Results Non-neoplastic acinar cells were stained diffusely, but epithelial cells of the pancreatic duct and the islets of Langerhans were not stained. In pancreatic tumours, all the seven ACCs were diffusely positive for the 2P-1-2-1 antibody. However, no positive staining was found in other pancreatic tumours including NETs, SPNs and ductal adenocarcinomas. The sensitivity and specificity of the 2P-1-2-1 antibody for ACCs were both 100%. In other organs studied, positive staining was observed only in the ectopic pancreas. ...
Parotid Gland Acinic Cell Carcinoma (Acinic Cell Carcinoma of Parotid): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
NOTOC__ {{Acinic cell carcinoma}} {{CMG}}; {{AE}} {{RG}} == Overview == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. == Primary Prevention == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. ==References== {{Reflist,2}} {{WH}} {{WS ...
Acinic cell carcinoma (ACC) is a low-grade salivary gland malignancy characterized by serous acinar differentiation. Most ACCs arise in the parotid gland, but ACCs have been reported to originate in nonparotid salivary glands where serous acini are less abundant. Given the recent discovery of mammary analog secretory carcinoma (MASC)-a salivary malignancy that histologically mimics ACC-a retrospective reevaluation of nonparotid ACCs is warranted. The surgical pathology archives of The Johns Hopkins Hospital were searched for all ACCs arising outside of the parotid gland. For each case, the histologic slides were reviewed; immunohistochemical analysis (mammaglobin, S100 protein) was performed; and confirmatory ETV6 breakapart fluorescence in situ hybridization assay was completed. Demographic and clinical data were obtained from the medical records. Fourteen extraparotid tumors diagnosed as ACC were identified. Eleven of 14 (79%) tumors harbored the ETV6 translocation (oral cavity=9 of 11; ...
RESULTS: We defined three distinctive phases-termed inflammation, regeneration and refinement-following induction of moderate acute pancreatitis in wild-type mice. These corresponded to different waves of proliferation of mesenchymal, progenitor-like and acinar cells. Pancreas regeneration required a coordinated transition of proliferation between progenitor-like and acinar cells. In mice harbouring an oncogenic Kras mutation and challenged with pancreatitis, there was an extended inflammatory phase and a parallel, continuous proliferation of mesenchymal, progenitor-like and acinar cells. Analysis of high-resolution transcriptional data from wild-type animals revealed that organ regeneration relied on a complex interaction of a gene network that normally governs acinar cell homeostasis, exocrine specification and intercellular signalling. In mice with oncogenic Kras, a specific carcinogenic signature was found, which was preserved in full-blown mouse pancreas cancer ...
Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal adenocarcinoma (PDAC). The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase the likelihood of PDAC development are poorly understood. We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed KrasG12D acinar cells is associated with PDAC development and maintenance of malignancy in human cells and mice. p62 accumulation promotes neoplastic progression by controlling the NRF2-mediated induction of MDM2, which acts through p53-dependent and -independent mechanisms to abrogate checkpoints that prevent conversion of differentiated acinar cells to proliferative ductal progenitors. MDM2 targeting may be useful for preventing PDAC development in high-risk individuals ...
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Although the gemcitabine is an effective chemotherapeutic agent for pancreatic cancer, unacceptable side effects often accompany. Since we have previously discovered that PKCγ C1B domain peptides effectively control tumor growth without any side effect (Kawabata et. al, Cancer Biol Ther, 2012), we sought to examine the efficacy of co-treatment with this peptide and a low dose of gemcitabine on the growth of pancreatic cancer. Although individual and co-treatment with C1B5 peptide (1µM) and gemcitabine (20 nM) weakly inhibited growth of PAN02 murine pancreatic acinar cell carcinoma in 2D culture, either treatment effectively attenuated spheroid growth on PAN02 cells in 3D culture with 48.2% and 35.8% inhibition, respectively. Combination treatment with the C1B5 peptide and gemcitabine further attenuated the growth of PAN02 cells (69.5% inhibition). In mice bearing peritoneal allograft tumors of PAN02 cells (2.5 x 105 cells/mouse), combination treatment with C1B5 peptide at 20 mg/kg (every other ...
BACKGROUND: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. MAIN BODY: Recent advances in whole exome sequencing, gene expression profiling, and knowledge ... read more of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. CONCLUSION: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma. show less ...
Answer: Acinic cell adenocarcinoma. Histology: The tumor is composed of sheets of predominantly serous (acinic) cells which are associated with dense bands of fibroses and lymphoid reaction. Occasional cells show vacuolization which gives rise to a microcystic pattern. Striated ducts are not present within the tumor.. Discussion: When they are composed of predominantly acinic cells, acinic cell adenocarcinomas can be difficult to distinguish from normal parotid gland tissue. The absence of striated ducts, the presence of stromal fibrosis, a polygonal cell shape (as opposed to the triangular appearance of normal acinar cells), and the lack of a normal lobular pattern favor carcinoma. Acinic cell carcinomas are often associated with a lymphoid reaction often designated TALP (Tumor-Associated Lymphoid Proliferation). This raises the differential diagnosis of a metastasis to intraparotid lymph nodes. TALP, unlike lymph nodes, lacks a fibrous capsule and a subcapsular sinus. Oncocytomas are composed ...
Synonyms for acinar carcinoma in Free Thesaurus. Antonyms for acinar carcinoma. 28 words related to carcinoma: cancer of the liver, liver cancer, cancer, malignant neoplastic disease, adenocarcinoma, glandular cancer, glandular carcinoma. What are synonyms for acinar carcinoma?
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two Phase 1 studies in patients with advanced or metastatic solid tumors, including patients with active CNS disease. Here we summarize the overall safety and report the antitumor activity of entrectinib in a cohort of patients with tumors harboring NTRK1/2/3, ROS1, or ALK gene fusions, naïve to prior TKI treatment targeting the specific gene, and who were treated at doses that achieved therapeutic exposures consistent with the RP2D. Entrectinib was well tolerated, with predominantly Grades 1/2 adverse events that were reversible with dose modification. Responses were observed in NSCLC, colorectal cancer, mammary analog secretory carcinoma, melanoma, and renal cell carcinoma, as early as 4 weeks after starting treatment and lasting as long as , 2 years. Notably, a complete CNS response was achieved in a patient with SQSTM1-NTRK1-rearranged lung cancer. ...
A neoplastic human salivary intercalated duct cell clone was cultured in 5 µm 5-azacytidine for 5 days at 37°C; then the cells were trypsinized and subcultured in growth medium without 5-azacytidine. Thereafter, subclones were cloned from the subculture. Of 12 subclones isolated, 7 clonal cell lines were established and characterized. The two subclones composed of cells which were spindle shaped or stellate exhibited phenotypes similar to those of myoepithelial cells such as microfibrils and myosin and formed a myoepithelioma upon transplantation of the cells into nude mice. The other five subclones were composed of polygonal cells with numerous secretory granules in their cytoplasm and containing amylase that seems to be specific to acinar cells; transplantation of these cells into nude mice resulted in production of acinic cell carcinoma. These findings indicate that a neoplastic human salivary intercalated duct cell is capable of at least bidirectional differentiation.. ...
Although having a documented history of Gleason score 7 prostate adenocarcinoma, and tumour morphology consisent with metastatic prostate adenocarcinoma, confirmatory immunohistochemistry studies are still required to be performed to determine th...
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BAR HARBOR, Maine -- The remarkable coincidence of two rare malignancies in some children is leading to a new understanding of how other, more common cancers arise.The research, outlined at a recent
1BHY: Multiwavelength anomalous solvent contrast (MASC): derivation of envelope structure-factor amplitudes and comparison with model values.
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acinar cell carcinoma of the pancreas answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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Overview of insulin resistance what it means why it occurs and tests ordered when insulin resistance is suspected. Energy Drink Death 2017 diabetic Living; Eat This Recipes; Cinnamon Rolls. What Should Your Blood Sugar Level Be in the Morning? High blood sugar levels during pregnancy can cause your baby to be larger than average at birth Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. My Gestational Diabetes Diet Diary. Acinar cell carcinoma g.. How do I make a healthier pie crust?" is a frequent question from readers. Energy Drink Death 2017 Executive summary of our review of the UST400 system Diabetes , Diabetes diet Please note that this menu is not intended for patients with type 1 diabetes How to stay healthy while having fun in Presentation Why Research Networks in England? Diabetes Research Network NE London local coverage and set up If youve got five foil mini loaf pans weve got a recipe to fill them withlike these rich moist ...
Tumor-infiltrating neutrophil (TIN) has been reported to be an independent predictor in multiple tumors, but its role in the development of adenocarcinoma of the esophagogastric junction (AEG)...
Prostate cancer is the third commonest malignancy among Singaporean men. The increase can be attributed to aging population, serum PSA screening and the application of TRUS. 170 cases of prostatic acinar adenocarcinoma of male patients who underwent radical prostatectomy were being studied. Clinicopathological and histological parameters were being evaluated against biomarkers - p53, Ki-67, androgen receptor, Her-2/neu, chromogranin A, CD56 and synaptophysin to determine if correlation can be established. Ki-67 and p53 have been found to be associated with adverse pathological variables. Ki-67 was positively correlated to PSA level as indicated by a p value of 0.041 while p53 intensity was positively correlated to Gleason score as indicated by p value of 0.018. Ki-67 and p53 were also observed to be positively correlated with AR. Ki-67 immunoreactive score (IRS) was positively correlated to AR IRS as indicated by p value of 0.055; p53 intensity-percentage score (IPS), p53 IRS were positively ...
Semantic Scholar extracted view of [Factors deciding survival rate after resection of pancreatic neoplasms. 5). Perineural invasion]. by Satomi Suzuki Uematsu et al.
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Acinar cell carcinoma of lung|Adenocarcinoma of lung|Adenocarcinoma of lung (disorder)|Adenocarcinoma of lung, stage I|Adenocarcinoma of lung, stage I (finding)|Adenocarcinoma of lung, stage II|Adenocarcinoma of lung, stage II (finding)|Adenocarcinoma of lung, stage III|Adenocarcinoma of lung, stage III (finding)|Adenocarcinoma of lung, stage IV|Adenocarcinoma of lung, stage IV (finding)|Adenoid cystic carcinoma of lung|Adenosquamous carcinoma of lung|Alveolar cell carcinoma|BC - Bronchogenic carcinoma|Basaloid squamous cell carcinoma of lung|Bronchial carcinoma|Bronchiolar adenocarcinoma|Bronchiolar carcinoma|Bronchioloalveolar carcinoma|Bronchioloalveolar carcinoma (disorder)|Bronchioloalveolar carcinoma - disorder|Bronchoalveolar cancer|Bronchogenic carcinoma|CA - Cancer of bronchus|CA - Carcinoma of bronchus|CA - Lung cancer|Cancer of bronchus|Carcinoma of bronchus|Carcinoma of lung|Carcinoma of lung parenchyma|Carcinoma of lung parenchyma (disorder)|Carcinosarcoma of lung|Clear cell squamous cell
Treatment of mucinous cystic pancreatic neoplasms mainly involves surgical resection[14][15]. The surgery involves distal pancreatic resection with or without splenectomy. Other surgical procedures include pancreaticoduodenectomy, enucleation, middle pancreatectomy, or total pancreatectomy[16]. In published trials, there is no significant mortality associated with surgery. However, postoperative morbidity can be as high as 49%[17]. It is still recommended practitioners pursue non-operative management for tumors that are smaller than 3 cm and without mural nodules, specifically in elderly patients with co-morbidities[18][19]. This is because mucinous cystic pancreatic neoplasms that are smaller than 4 cm and with no nodules are usually adenomas or borderline neoplasms. Hence, the patients mentioned above can be followed with serial imaging. Conversely, middle-aged women with a long life expectancy presenting with mucinous cystic pancreatic neoplasms, surgical resection is recommended as many of ...
The role of tuberous sclerosis complex (TSC) in the pathogenesis of pancreatic cancers remains largely unknown. The present study shows that neurogenin 3 directed Cre deletion of Tsc1 gene induces the development of pancreatic acinar carcinoma. By cross-breeding the Neurog3-cre mice with Tsc1(loxp/loxp) mice, we generated the Neurog3-Tsc1-/- transgenic mice in which Tsc1 gene is deleted and mTOR signaling activated in the pancreatic progenitor cells. All Neurog3-Tsc1-/- mice developed notable adenocarcinoma-like lesions in pancreas starting from the age of 100 days old. The tumor lesions are composed of cells with morphological and molecular resemblance to acinar cells. Metastasis of neoplasm to liver and lung was detected in 5% of animals. Inhibition of mTOR signaling by rapamycin significantly attenuated the growth of the neoplasm. Relapse of the neoplasm occurred within 14 days upon cessation of rapamycin treatment. Our studies indicate that activation of mTOR signaling in the pancreatic ...
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Principal Investigator:SHIMIZU Michio, Project Period (FY):2001 - 2003, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Human pathology
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Discussion: Parotid gland neoplasms are quite rare in the pediatric population but when such a lesion is encountered, a higher percentage (40-50%) will be malignant when compared to the adult population (25-35%); therefore, parotid neoplasms in children must be approached with suspicion (1). The mean age at which malignant parotid gland neoplasms occur in the pediatric population is 13.2 years (2). Acinic cell carcinoma (ACC) accounts for an appreciable number of pediatric parotid malignancies; in fact, it is the second most common malignant parotid tumor in this population followed by mucoepidermoid carcinoma (3). Nasse first described the lesion in a 1892 publication in which four cases of parotid adenomas were described (4). Due to the similarity of the tumor cells to normal salivary tissue, the lesions were initially regarded as benign. The benignity of the lesion was questioned in 1953 when Buxton et al. reported three cases of ACC with verified distant metastases (5). Therefore, the lesion ...
Paraneoplastic syndromes.. Pathology and tumours of the naso-pharyngeal region: general features; specifically: naso-pharyngeal carcinoma.. Larynx: general features; specifically: nodules and polyps of the vocal cords; solitary papilloma and papillomatosis; Laryngeal carcinoma and precursor lesions.. Diseases of the Thymus. Developmental disorders.. Thymic hyperplasia.. Thymomas.. (A, AB, B1, B2, B3, C).. Thymic carcinoid.. Salivary gland pathology. Pleomorphic adenoma, Warthin tumor; acinic cell carcinoma; mucoepidermoid carcinoma; adenoid-cystic carcinoma; benign and malignant lympho-epithelial lesions. Cysts of the head and neck region.. Diseases of the Gastro-Intestinal system. Esophageal diseases. Pathology and pathogenesis of: esophagitis, Barretts esophagus, squamous carcinoma and adenocarcinoma of the esophagus. Non neoplastic gastric diseases. Pathology and pathogenesis of: gastritis (acute and chronic) and gastric ulcer (peptic and acute). Ménétrieres disease.. Tumor and tumorlike ...
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
Define acinar cell, acinous cell. acinar cell, acinous cell synonyms, acinar cell, acinous cell pronunciation, acinar cell, acinous cell translation, English dictionary definition of acinar cell, acinous cell. a small room as in a convent or prison; basic structural unit of all organisms: a one-celled animal Not to be confused with: sell - to transfer goods or...
Definition of acinar cell in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is acinar cell? Meaning of acinar cell as a legal term. What does acinar cell mean in law?
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To protect acinar cells from self-digestion, the powerful digestive enzymes that the cells make are initially produced in an inactive form, notes Pancreas.org. These inert enzymes are converted into...
Malignancies, some deadly, are actually documented amid children, adolescents, and youthful Older people who acquired cure with TNF-blockers (initiation of therapy ≤ 18 a long time of age), of which HUMIRA can be a member [see BOXED WARNING]. Approximately 50 % the cases had been lymphomas, like Hodgkins and non-Hodgkins lymphoma. One other cases represented a variety of various malignancies and incorporated rare malignancies ordinarily associated with immunosuppression and malignancies that are not normally noticed in young children and adolescents ...
TY - JOUR. T1 - Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas. AU - Tang, Wendell W.. AU - Stelter, Arwen A.. AU - French, Samuel. AU - Shen, Steven. AU - Qiu, Suimin. AU - Venegas, Rose. AU - Wen, Julie. AU - Wang, Hui Qun. AU - Xie, Jingwu. PY - 2007/5/30. Y1 - 2007/5/30. N2 - Solid pseudopapillary tumor of pancreas (SPT) is a rare neoplasm that occurs most often in young females with the two distinct features, the solid-cystic gross appearance, and the solid-pseudopapillary microscopic pattern. It has been reported that almost all SPT tumors contain a mutation in the β-catenin gene; however, the histogenetic origin of this tumor remains largely a mystery. E-cadherin is a cell adhesion molecule that links to catenins to form cell adhesion junctions, which is associated with the cytoskeleton formation. In this study, we examined the expression of E-cadherin and β-catenin from SPT in an attempt to determine the molecular basis for the unusual ...