Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue (or in cells that display epithelial characteristics) that bear microscopic resemblance to lymphoepithelioma (nasopharyngeal carcinoma). There is considerable variation in the classification of LELC-while it is perhaps most commonly considered a subtype of squamous cell carcinoma, it can also be classified as a form of large cell carcinoma (i.e. when occurring in the lung), and can be considered as a separate, unique entity. In most anatomical sites, many cases are associated with the Epstein-Barr virus. In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator. Nasopharyngeal carcinoma Lymphoepithelioma Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. ...
This study has shown that immunohistochemical expression of DBC1 was significantly associated with advanced clinicopathological factors of ovarian carcinoma such as higher tumor stage, latent distant metastasis, platinum-resistance, elevated serum level of CA125, and higher histologic grade. Moreover, DBC1 expression was significantly associated with shorter survival of ovarian carcinomas, especially in high-grade serous carcinomas. In agreement with our results, increased expression of DBC1 has been reported as an indicator of poor prognosis of gastric carcinoma [15], breast carcinoma [14], colorectal carcinoma [9], esophageal carcinoma [20], clear cell renal cell carcinoma [12], diffuse large B cell lymphoma [13], and soft tissue sarcomas [13]. Nevertheless, there has been no report investigating DBC1 expression in ovarian carcinomas. Therefore, this is the first report that examined DBC1 expression in human ovarian tumors and suggests that DBC1 expression might be usable as a prognostic ...
carcinoma - MedHelps carcinoma Center for Information, Symptoms, Resources, Treatments and Tools for carcinoma. Find carcinoma information, treatments for carcinoma and carcinoma symptoms.
Anaplastic carcinoma is a rare type of thyroid cancer that can cause severe breathing difficulties. The main signs of anaplastic...
Dr. Thompson responded: Possibly. Undifferentiated carcinoma means that the tumor is not showing the normal patterns seen for a transitional or urothelial (lining of the |a href="/topics/bladder" track_data="{
Background : Interval carcinoma is defined as a carcinoma detected between two mammographic screening rounds after a negative screening. By some authors these carcinomas are considered to be more aggressive than screen-detected carcinomas. Methods : In a group of 937 patients referred for breast cancer in the period 1975-1990,76 interval...
Beim Carcinoma in situ der Brust unterscheiden wir 2 Formen: Das ductale und das lobuläre Carcinoma in situ. Das letztere wird von den Pathologen in der Regel nicht mehr als echtes Carcinoma...
The ICD-10 Code D09.19 is the code used for Carcinoma in situ of other urinary organs .An alternative description for this code is Carcinoma in situ of other urinary ...
Definition of Carcinoma myxomatodes with photos and pictures, translations, sample usage, and additional links for more information.
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... - Una variante anaplásica del carcinoma epidermoide, denominada linfoepitelioma en amígdala palatina/lingual, tenían menos probabilidades de aparecer en.
The case histories of six patients are presented where the diagnosis of carcinoma of the esophagus and the stomach was made at the same time by barium stud
Sigma-Aldrich offers abstracts and full-text articles by [Xiaoli Yang, Cui Wang, Changzhi Xu, Zhifeng Yan, Congwen Wei, Kai Guan, Shengli Ma, Ye Cao, Liping Liu, Deyong Zou, Xiang He, Buchang Zhang, Qingjun Ma, Zirui Zheng].
INTRODUÇÃO: O carcinoma basocelular (CBC) é o tipo de câncer cutâneo mais comum no ser humano. O aparecimento de CBC na maioria das vezes se dá de forma esporádica em indivíduos que se expõem cronicamente...
Mediante el Tratamiento Inmunobiológico Issels y sin necesidad de ningún otro tratamiento convencional, se logró una remisión completa a largo plazo de la tercera recurrencia de un carcinoma cervical avanzado de células escamosas inoperable.
Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The ...
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Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cells (8305c cells). To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis. Apoptosis was analyzed with Hoechst 33342 staining and DNA ladder formation assay. 8305c cells became radiosensitive when glycerol was added to culture medium before X-ray irradiation. Apoptosis was induced by X-rays in the presence of glycerol. However, there was little apoptosis induced by X-ray irradiation or glycerol alone. The binding activity of whole cell extracts to bax promoter region was induced by X-rays in the presence of glycerol but not by X-rays alone. These findings suggest that glycerol is
Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Anaplastic thyroid carcinoma presented as a large neck mass with necrosis in 82% of cases. The tumors demonstrated common extrathyroidal extension (91%). Sixty-two percent of tumors demonstrated calcification. Visceral space invasion involved the esophagus (62%), trachea (57%), and larynx (29%). Carotid artery encasement was present in 42%, and 43% involved the internal jugular vein. Sixty-three percent had lateral compartment lymphadenopathy; 58% of these nodes were necrotic, and 11% were cystic. No metastatic nodes had calcification. Central compartment lymphadenopathy was seen in 56% of cases, and lateral retropharyngeal lymphadenopathy was detected in 12%. Knowledge of these imaging features aids in guiding ...
TY - JOUR. T1 - PD-1 Blockade in Anaplastic Thyroid Carcinoma. AU - Capdevila, Jaume. AU - Wirth, Lori J.. AU - Ernst, Thomas. AU - Ponce Aix, Santiago. AU - Lin, Chia Chi. AU - Ramlau, Rodryg. AU - Butler, Marcus O.. AU - Delord, Jean Pierre. AU - Gelderblom, Hans. AU - Ascierto, Paolo A.. AU - Fasolo, Angelica. AU - Führer, Dagmar. AU - Hütter-Krönke, Marie Luise. AU - Forde, Patrick M.. AU - Wrona, Anna. AU - Santoro, Armando. AU - Sadow, Peter M.. AU - Szpakowski, Sebastian. AU - Wu, Hongqian. AU - Bostel, Geraldine. AU - Faris, Jason. AU - Cameron, Scott. AU - Varga, Andreea. AU - Taylor, Matthew. PY - 2020/8/10. Y1 - 2020/8/10. N2 - PURPOSE: Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease. As part of a phase I/II study in patients with advanced/metastatic solid tumors, patients with anaplastic thyroid carcinoma were treated with spartalizumab, a humanized ...
Medical information, Anaplastic carcinoma of the thyroid. Definition of Anaplastic carcinoma of the thyroid, symptoms of Anaplastic carcinoma of the thyroid, treatment of Anaplastic carcinoma of the thyroid, and prevention of Anaplastic carcinoma of the thyroid. Exams and Tests Anaplastic carcinoma of the thyroid.
This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of miR-34b. Immunocytochemistry, Western blot and ELISA were carried out to determine the effect of this manipulation on VEGF-A expression. In addition, an in vivo xenotransplantation mouse model was used to investigate the functional roles of overexpression of miR-34b in the carcinoma. In anaplastic thyroid carcinoma cells, miR-34b expression was low and significant overexpression (p , 0.05) was noted following transfection with liposome-loaded miR-34b. The miR-34b overexpressed thyroid carcinoma cell lines showed reduction in VEGF-A protein expression, decreased cell proliferation, decreased wound healing, reduced cell cycle ...
TY - JOUR. T1 - Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1. T2 - A paradigm shift that impacts current therapeutic strategies. AU - Marlow, Laura A.. AU - von Roemeling, Christina A.. AU - Cooper, Simon J.. AU - Zhang, Yilin. AU - Rohl, Stephen D.. AU - Arora, Shilpi. AU - Gonzales, Irma M.. AU - Azorsa, David O.. AU - Reddi, Honey V.. AU - Tun, Han W. AU - Dö ppler, Heike R.. AU - Storz, Peter. AU - Smallridge, Robert Christian. AU - Copland, John A III. PY - 2012. Y1 - 2012. N2 - The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth through transcriptional regulation of key genes regulating cell cycle arrest and apoptosis. In many types of cancer, in response to growth factor signaling, FoxO3a is phosphorylated by Akt, resulting in its exclusion from the nucleus. Here we show that FoxO3a remains nuclear in anaplastic thyroid carcinoma (ATC). This correlates with lack of Akt phosphorylation at ...
Lymphoepitheliomas are malignant epithelial tumors of the nasopharynx characterized by an important lymphoid proliferation at histological examination. Lymphoepithelioma-like carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. We report the case of a 64-year-old Moroccan man who presented with macroscopic hematuria. Investigations revealed a muscle-invasive lymphoepithelioma-like carcinoma of the bladder. Therefore he underwent a radical cystoprostatectomy with a good outcome. This case illustrates pathogenic, clinical and therapeutic features of this unusual tumor.
Health, ...Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer wit...Led by Professor H. Phillip Koeffler Senior Principal Investigator a...Thyroid cancer is the most common cancer of the endocrine system. ATC ... The effect of LAMC2 on ATC cells ...,NUS,researchers,make,new,discovery,of,protein,as,a,promising,target,for,treatment,of,ATC,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
... is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.. Nasopharyngeal carcinoma is difficult to detect early, probably because the nasopharnyx isnt easy to examine and symptoms of nasopharyngeal carcinoma mimic those of many other conditions. Your main treatment options for nasopharyngeal carcinoma are radiation therapy, chemotherapy or a combination of the two. You can work with your doctor to determine the exact approach depending on your particular situation.. Risk factors. Nasopharyngeal carcinoma is common in Southern China. It often affects people aged 30 and older, but occasionally can be seen in the young, including children. It is twice as common in women.. Several risk factors have been found with nasopharyngeal cancer:. Diet: In areas where nasopharyngeal carcinomas are common, people typically eat diets very high in salted fish and preserved meat from a young ...
Purpose: The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.. Methods: Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.. Results: The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more ...
If the tumor has all of these features, it is considered to be a "true" medullary carcinoma. Sometimes the tumor has only some of these features but not others, or there may be some invasive ductal carcinoma cells mixed in. In these cases, your doctor may call the tumor "atypical medullary carcinoma.". In addition, medullary carcinoma cells often express a protein called p53. The pathologist may test for p53 to help decide if the cancer is truly medullary.. There are some other key features of medullary carcinoma:. ...
Staging of carcinoma refers to the process of combining physical/clinical examination, pathological review of cells and tissues, surgical techniques, laboratory tests, and imaging studies in a logical fashion to obtain information about the size of the neoplasm and the extent of its invasion and metastasis. Carcinomas are usually staged with Roman numerals. In most classifications, Stage I and Stage II carcinomas are confirmed when the tumor has been found to be small and/or to have spread to local structures only. Stage III carcinomas typically have been found to have spread to regional lymph nodes, tissues, and/or organ structures, while Stage IV tumors have already metastasized through the blood to distant sites, tissues, or organs. In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable only via examination of sputum for malignant cells (in lung carcinomas). In more recent staging systems, substages (a, b, c) are becoming ...
Radiation and chemotherapy are common treatments for anaplastic carcinoma. Learn about treatments for anaplastic carcinoma, a type of thyroid cancer.
Hemonc Today | The American Thyroid Association has released the first set of comprehensive guidelines for the management of anaplastic thyroid cancer, a rare but lethal form of thyroid cancer. Members of the American Thyroid Association (ATA) task force compiled a list of 65 recommendations based on relevant literature.
It was reported previously that the specific aim of screening agents that would induce apoptosis in the human breast carcinoma cell line MDA-MB-231 was completed, and that calyculin A was the most effective compound tested. Since then Cdc25 phosphatases were reported as possible key oncogenes in human breast carcinoma. In light of our results with calyculin A, it was decided that a more promising focus for the project would be the biochemical basis for the oncogenic actions of Cdc25 phosphatases in human breast carcinoma. At this time we have examined 18 compounds and discovered a Cdc25 phosphatase inhibitor, called 1f, that selectively inhibits Cdc25A,B, and C, has antiproliferative activity against and causes a G1 block in MDA-MB-231 cells. The pure form of this compound and two other compounds which selectively inhibit Cdc25 phosphatases have been made and also demonstrate an equal if not better inhibition of Cdc25 phosphatases as their combinatorial form.*HUMANS
Information about anaplastic thyroid cancer, a rare but deadly form of thyroid cancer that mainly affects men over the age of 65.
The Anaplastic Thyroid Cancer GUIDELINES Pocket Card is endorsed by the American Thyroid Association reflects the latest ATA recommendations. This practical quick-reference tool contains graded recommendations for diagnosis, including immunohistochemical markers, and treatment of local, regional and metastatic disease with management algorithms and tables of chemotherapy and adjuvant/radiosensitizing regimens. Also included are recommendations for palliative care and long-term monitoring. Spiral Bound 14 pages 80# Diamond Silk Cover with Satin Aqueous Coating 4.5″ x 7.25″
This form of cancer has an extremely low cure rate. The best treatments available allow only 10% of patients live 3 years after diagnosis. A larger percentage of patients diagnosed with it do not live beyond one year from the day cancer is diagnosed. It can arise within a different type of thyroid cancer. It can even form within a goiter. Anaplastic thyroid cancer can develop after many, many years following radiation exposure. Papillary cancer develops the same way. Cervical metastasis is when the cancer spreads to the lymph nodes in the neck. This is present in over 90% of patients diagnosed with anaplastic thyroid cancer. The appearance of lymph node metastasis in cervical areas cause much higher recurrence rate of anaplastic thyroid cancer and increases a patients mortality rate. The cancer becomes noticeable as growing neck mass. It can feel large and very hard. This type of tumor grows very quickly. It may grow so quickly that the patient may not even notice it at first. All of a sudden, ...
It was confirmed that CD147 (Emmprin) was expressed on the cell surface of carcinoma cells. For the purpose of studying the efficacy of a CD147-targeting agent on CD147-expressing carcinoma cells, we investigated the effect of a conjugate of glutathione-doxorubicin (GSH-DXR) encapsulated in an anti-CD147 antibody-labeled liposome (aCD147ab-liposome) in terms of specific accumulation and cytotoxicity in CD147-expressing human carcinoma cells. Expression of CD147 was not observed in many normal human tissues. However, slight expression of CD147 in kidney, prostate and breast tissues was observed. By contrast, high-level expression of CD147 in all carcinoma cells such as A431, PC3 and Ishikawa cell lines was confirmed by fluorescent microscopy and Western blot analysis. Specific accumulation of the aCD147ab-liposome in the above-described CD147-expressing cells was observed. GSH-DXR encapsulated in an aCD147ab-liposome expressed specific cytotoxicity against these carcinoma cells. These results ...
TY - JOUR. T1 - How matching may impact interpretation. T2 - Comments on "A matched-cohort analysis of 192 pancreatic anaplastic carcinomas and 960 pancreatic adenocarcinomas: A 13-year North American experience using the National Cancer Data Base (NCDB)". AU - Bergquist, John R.. AU - Thiels, Cornelius A.. AU - Storlie, Curtis B.. AU - Nagorney, David M.. AU - Truty, Mark J.. PY - 2016/12/1. Y1 - 2016/12/1. UR - http://www.scopus.com/inward/record.url?scp=84979650457&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84979650457&partnerID=8YFLogxK. U2 - 10.1016/j.surg.2016.05.011. DO - 10.1016/j.surg.2016.05.011. M3 - Letter. C2 - 27365227. AN - SCOPUS:84979650457. VL - 160. SP - 1714. EP - 1715. JO - Surgery (United States). JF - Surgery (United States). SN - 0039-6060. IS - 6. ER - ...
Principal Investigator:TANIGUCHI Shin-ichi, Project Period (FY):2003 - 2004, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Endocrinology
An open right-sided neck biopsy was performed. Histology: MACROSCOPIC DESCRIPTION: Two specimens received. Right neck mass 1: Multiple irregular cream necrotic pieces of tissue measuring 20x15x4 mm in aggregate. Right neck mass 2: Multiple ta...
Hiraki, M.; Kitahara, K.; Miyoshi, A.; Koga, H.; Nakamura, H.; Kubo, H.; Ikeda, O.; Yoshioka, W.; Nakashita, S.; Nishihara, Y.; Akashi, M.; Azama, S.; Kawaguchi, Y.; Mori, D.; Aishima, S.; Aibe, H.; Tanaka, T.; Sato, S., 2018: A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review
A method of killing carcinoma cells associated normal cells using light of a predetermined wavelength. The method includes contacting the cells with a chromophor at a given concentration. The chromophor is positively charged and sufficiently lipophilic to be taken up by the mitochondria of the carcinoma cells and is retained substantially longer in the mitochondria of carcinoma cells than in normal cell mitochondria; or it may be taken up in greater quantity by the carcinoma cells than by the normal cells. The chromophor must also have a therapeutic index for light-induced cell killing of at least 500 for light of the predetermined wavelength, and has a therapeutic ratio for light-induced killing of at least 50 for light of said pre-determined wavelength. The cells are then exposed to light of this wavelength.
The most striking finding of this study was that the dimension of symptom intensity and the dimension of symptom distress were not equivalent. There also was remarkable consistency in the TSSD-LC data on symptom distress over time in all subgroups examined, whereas patterns of intensity were highly variable. The 3 symptoms-breathing, pain, and fatigue-were associated with the most distress in this sample of 400 patients with inoperable lung carcinoma.. It should be noted, however, that the sample in this study represents the healthiest of this very ill patient group, because participants were younger and had longer survivals than both nonparticipants and the population of patients with inoperable lung carcinoma registered in the same geographic area. Recruitment and participation in this study compared favorably with other studies, considering the well acknowledged difficulties in researching patients with lung carcinoma, debilitated patients, and women with lung carcinoma.3, 27-30 The low ...
Another name for Gastric Carcinoma is Gastric Carcinoma. It is important to follow a healthy diet if you have gastric carcinoma. Cancer and Chemotherapy ...
Diffuse-type gastric carcinoma (DGC) cell lines with robust overexpression of Met are sensitive to Met inhibitors. (a) DGC and other gastric carcinoma cell line
class III nasopharyngeal carcinoma in the WHO classification system (Lymphoepithelioma) -- For more information on this topic, see Nasopharyngeal carcinoma Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor. fact lexicon with terms going straight to the point. Facts are sorted by community importance and you can build your personalized lexicon
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Help. I have just put out a message on ask for advice. But I need to get all the informaton I can on this type of cancer. FRiday my mother in law was here with...
Cancer of unknown primary site represents approximately 3% to 5% of all new cancer diagnoses. Adenocarcinomas account for 60% of all unknown primary cancers and poorly differentiated carcinomas or 1
Prognostic relevance of LGALS3BP in human colorectal carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Ovarian cancer is a cancer that forms in an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. SK-OV-3, NIH:OVCAR-3 and HO-8910 are the ovarian carcinoma cell lines derived from human ovarian tumor. Studies were carried out to determin