... ,Disposable paper cups or hidden potential carcinogens,Disposable paper cups or hidden potential carcinogens
論文:Final Report on Carcinogens Background Document fo...[Report on carcinogens background document for [substance name]] - Pubmed Result(ATGCchecker)の詳細情報です。フルテキスト情報、関連する論文情報も掲載。
Project [Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens (COMPLETED)] has been completed and the following reports have been generated ...
Project [Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens (COMPLETED)] has been completed and the following reports have been generated ...
Iannaccone, P M. and Tsao, T Y., "Acute effects of in vitro exposure to chemical carcinogens on preimplantation mouse embryos. Abstr." (1980). Subject Strain Bibliography 1980. 2117 ...
It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Non-genotoxic carcinogens act by the mechanisms such as induction of inflammation, immunosuppression, formation of reactive oxygen species, activation of receptors, and epigenetic silencing. Together, these genotoxic and non-genotoxic mechanisms can alter signal-transduction pathways that finally result in hypermutability, genomic instability, loss of proliferation control, and resistance to apoptosis - some of the ...
It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens act through a variety of genotoxic and non-genotoxic mechanisms. Genotoxic carcinogens can attack biological macromolecules such as DNA and RNA either directly or indirectly through metabolism, resulting in the formation of adducts with these macromolecules. If DNA adducts escape cellular repair mechanisms and persist, they may lead to miscoding, resulting in permanent mutations. Non-genotoxic carcinogens act by the mechanisms such as induction of inflammation, immunosuppression, formation of reactive oxygen species, activation of receptors, and epigenetic silencing. Together, these genotoxic and non-genotoxic mechanisms can alter signal-transduction pathways that finally result in hypermutability, genomic instability, loss of proliferation control, and resistance to apoptosis - some of the ...
When carcinogens are involved at the workplace, employers have to do everything in their power to prevent workers coming into contact with these substances.
Today, the House Science, Space, and Technology Committee and House Small Business Committee held a joint hearing on the National Toxicology Programs (NTP) Report on Carcinogens. It is critical that the NTP use the best available, peer reviewed science when making its decisions on what chemicals to list, yet it clearly doesnt do that. Read the full story on CEIs OpenMarket.org.. ...
Definition of non-genotoxic carcinogen and genotoxic carcinogens and whether there are any thresholds for carcinogens from a regulatory perspective.
A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of cancer. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes. Several radioactive substances are considered carcinogens, but their carcinogenic activity is attributed to the radiation, for example gamma rays and alpha particles, which they emit. Common examples of non-radioactive carcinogens are inhaled asbestos, certain dioxins, and tobacco smoke. Although the public generally associates carcinogenicity with synthetic chemicals, it is equally likely to arise in both natural and synthetic substances.[1] Carcinogens are not necessarily immediately toxic; thus, their effect can be insidious.. Cancer is any disease in which normal cells are damaged and do not undergo programmed cell death as fast as they divide via mitosis. Carcinogens may increase the risk of cancer by altering cellular metabolism or damaging DNA directly in cells, which ...
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Genotoxicity in vitro - rat - Liver Sister chromatid exchange Signs and Symptoms of Exposure ...
Fig. 1. Inhibition of azoxymethane-induced ACF in the colon of rats by polyethylene glycols (PEG) of various molecular weights given at 5% in the drinking water for 30 d (see Methods, study 5). Data from two sequential experiments are shown here, and are plotted as percent of control values, i.e., 135 ± 33 and 81 ± 13 ACF in the first (hatched bars) and second (empty bars) experiment, respectively. Molecular weights are given in dalton, or kilodalton (k). Data are mean and SD from 10 rats (control groups), 4 rats (hatched bars), or 8 rats (empty bars). A star indicates that P , 0.01 compared with respective control value (Dunnetts test made on the actual numbers of ACF).. ...
American baby care products are not as safe as consumers may expect. The Campaign for Safe Cosmetics released a report on 48 baby care products that were tested for the carcinogens formaldehyde and 1,4-dioxane. The March 2009 report, entitled "No More Toxic Tub", reveals that 67 percent of the products tested contained detectable levels of 1,4-dioxane. 82 percent of the products tested contained detectable levels of formaldehyde and 1,4-dioxane. And 61 percent of products tested contained both.. Of the 48 products tested, only 28 were tested for formaldehyde. So theres a chance that if all products had been tested for both, the percentage of products contaminated with both could be higher than 61 percent.. The State of California classifies both chemicals as carcinogens under its Proposition 65 "The Safe Drinking Water and Toxic Enforcement Act of 1986" passed in 1986. Both were listed as carcinogens on January 1, 1988. The US EPA regards both as probable carcinogens ...
Learn how potential carcinogens are tested and classified, find lists of known and possible carcinogens, and learn about cancer clusters.
Researchers for the first time have developed a method to track through the human body the movement of polycyclic aromatic hydrocarbons, or PAHs, as extraordinarily tiny amounts of these potential carcinogens are biologically processed and eliminated.
Lung cancer is strongly associated with exogenous risk factors, in particular tobacco smoking and asbestos exposure. New research data are accumulating about the regulation of the metabolism of tobacco carcinogens and the metabolic response to oxidative stress. These data provide mechanistic details about why well known risk factors cause lung cancer. The purpose of this review is to evaluate the present knowledge of the role of cytochrome P450 (CYP) enzymes in the metabolism of tobacco carcinogens and associations with tobacco and asbestos carcinogenesis. Major emphasis is placed on human data and regulatory pathways involved in CYP regulation and lung carcinogenesis. The most exciting new research findings concern cross-talk of the CYP-regulating aryl hydrocarbon receptor with other transcription factors, such as nuclear factor-erythroid 2-related factor 2, involved in the regulation of xenobiotic metabolism and antioxidant enzymes. This cross-talk between transcription factors may provide mechanistic
No person shall distribute, sell, offer for sale, or expose for sale any art or craft material containing toxic substances causing chronic illness on which the person:. (a) Has failed to affix a conspicuous label containing the signal word "WARNING," to alert users of potential adverse health effects. (b) Has failed to affix a conspicuous label warning of the health-related dangers of the art or craft material. (1) If the product contains a human carcinogen, the warning shall contain the statement: "CANCER HAZARD! Overexposure may create cancer risk." (2) If the product contains a potential human carcinogen, and does not contain a human carcinogen, the warning shall contain the statement: "POSSIBLE CANCER HAZARD! Overexposure might create cancer risk." (3) If the product contains a toxic substance causing chronic illness, the warning shall contain, but not be limited to, the following statement or statements where applicable: (A) May cause sterility or damage to reproductive organs. (B) May ...
p,,b,BACKGROUND: ,/b,The aim of this work was to establish recommendations for the medical follow-up of workers currently or previously exposed to lung carcinogens.,/p,,p,,b,METHODS: ,/b,A critical synthesis of the literature was conducted. Occupational lung carcinogenic substances were listed and classified according to their level of lung cancer risk. A targeted screening protocol was defined.,/p,,p,,b,RESULTS: ,/b,A clinical trial, National Lung Screnning Trial (NLST), showed the efficacy of chest CAT scan (CT) screening for populations of smokers aged 55-74 years with over 30 pack-years of exposure who had stopped smoking for less than 15 years. To propose screening in accordance with NLST criteria, and to account for occupational risk factors, screening among smokers and former smokers needs to consider the types of occupational exposure for which the risk level is at least equivalent to the risk of the subjects included in the NLST. The working group proposes an algorithm that estimates ...
During this introductory online 13 Carcinogen safety class, we will teach you what carcinogens are and what they can do to the human body. Proper carcinogen training decreases the risk of fatal exposure and teaches what to do in case of exposure. Along with carcinogen safety, we will discuss your right to know and how medical surveillance impacts your life.. ...
IARC, the French-based cancer research department of WHO, released its findings Friday after studying the carcinogenicity of five insecticides and herbicides. News on NewsHub.org
What Carcinogens Are You Avoiding? - posted in Cancer: Are there any substances besides the obvious (smoking, being overweight, excess alcohol, exhaust fumes) that you are avoiding to prevent cancer? Are there any substances that are legally in the global food supply (preservatives, colorings and the like) that you are fairly convinced increase the probability of cancer and are therefore avoiding?
Tumor promotion is a critical event in cancer development and a potential target for chemopreventive measures. The multistage model of mouse skin carcinogenesis defines tumor development in terms of distinct stages and provides a standardized scheme for the investigation of tumor promoters. By using this model, a specific COX-2 inhibitor, celecoxib, was found to inhibit tumor formation by interfering with the promotion stage. Although COX-2 has been shown to catalyze the formation of genotoxic metabolites from polycyclic hydrocarbons (19), tumor initiation in skin by DMBA is not affected by celecoxib, whereas DMBA-induced breast cancer in rats was inhibited by this drug (7). Inhibition of postinitiation stages has also been observed for chemically induced colorectal carcinogenesis in rats (20). Thus, these studies indicate that COX-2 is involved in the promotion of both mouse skin and rat colon tumors.. As shown previously (15), transgenic overexpression of COX-2 in basal keratinocytes of mice ...
Because the scope of Volume 100 is so broad, its Monographs are focused on key information. Each Monograph presents a description of a carcinogenic agent and how people are exposed, critical overviews of the epidemiological studies and animal cancer bioassays, and a concise review of the agents toxicokinetics, plausible mechanisms of carcinogenesis, and potentially susceptible populations, and life-stages. Details of the design and results of individual epidemiological studies and animal cancer bioassays are summarized in tables. Short tables that highlight key results are printed in Volume 100, and more extensive tables that include all studies appear on the Monographs programme website (http://monographs.iarc.fr ...
Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people. ...
The main targets for antineoplastic drug in development are colorectal cancer, non-small cell lung cancer, breast and ovarian cancer. This reflects the frequency of the diseases. Lung cancer is the most common type of cancer, causing 24% of cancer deaths in UK males and 19% in females. Breast cancer and prostate cancer are the next most common cancers at 17% and 13% in the UK, while colorectal cancers account for around 10% of UK cancer deaths. There is also interest in drugs effective against less prevalent forms of cancer, partly because they may eventually provide treatments for other cancer types. The toxicity of many current antineoplastic is a major concern. Drugs which interfere with DNA and the cells ability to divide are also likely to introduce mutations, and are therefore potential carcinogens. For example, cyclophosphamide is listed as a human carcinogen and cisplatin as a probable carcinogen, by the International Agency for Research on Cancer. This means that these drugs can lead ...
Looking for epigenetic carcinogen? Find out information about epigenetic carcinogen. see cancer cancer, in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body... Explanation of epigenetic carcinogen
Looking for carcinogen? Find out information about carcinogen. see cancer cancer, in medicine, common term for neoplasms, or tumors, that are malignant. Like benign tumors, malignant tumors do not respond to body... Explanation of carcinogen
An overview of regulatory classification systems on carcinogens in the Organization for Economic Cooperation and Development (OECD) countries is presented based on a questionnaire study. Most OECD countries have implemented legislation including classification systems and lists of carcinogens. Basic...
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Limited daily exposure to toxins is tough in a pretty toxic world, but its a reasonable expectation that we all want to kick known carcinogens out of our homes. To that end, we asked Cara Bondi, a green scientists at Seventh Generation,
We compared effects of a high fat diet and a carcinogen on cellular elements of the spleen and mammary gland tumors in rats. Animals were fed a 15% olive-oil diet and a group of them were exposed to a carcinogen, dimethylbenz(a)antracne (DMBA), in two doses of 10 mg/rat. Results of the experiments were evaluated after 4 months. We studied changes in the areas of different zones of the spleen related to production of B and T lymphocytes and also the number of cells in the spleen and tumors with positive reaction to receptors related to manifestation of apoptosis (FasL and p53) and receptors related to inhibition of apoptosis (bcl-2). In the spleen, dietary fats as well as DMBA alone decreased the zones related to production of B lymphocytes and increased the number of T lymphocytes. The combined effect of a carcinogen and a high fat diet manifested in an increase in the number of lymphoid cells and macrophages. In tumors from rats fed a low-fat diet, an extremely high number of lymphoid cells was ...
JWH-18 is a synthetic cannabinoid with similar subjective effects to those of THC, active principle of marihuana. These last years this substance has become very popular and, as a consequence, the carcinogenic properties of this molecule have been widely discussed. In this text I will talk about the potential carcinogenicity of JWH-18. ___ JWH-18 (Fig.1) contains naphthalene in its structure (coloured in red). When we introduce naphthalene in our organism, it is going to pass through
JWH-18 is a synthetic cannabinoid with similar subjective effects to those of THC, active principle of marihuana. These last years this substance has become very popular and, as a consequence, the carcinogenic properties of this molecule have been widely discussed. In this text I will talk about the potential carcinogenicity of JWH-18. ___ JWH-18 (Fig.1) contains naphthalene in its structure (coloured in red). When we introduce naphthalene in our organism, it is going to pass through
Is anyone out there concerned about the hazardous materials we are exposed to daily in Histology? Such as Xylene, Formalin, and some of the other carcinogens used through out Histology. We keep the exposure levels under the limits but I still cant help but wonder if were in harms way. DAVE ...
Home testing and Human carcinogen - Iodine-131, diagnostic tests, self assessment, and other tools and products in relation to Human carcinogen - Iodine-131.
EXHAUST POLLUTION PREVENTION REDUCES CANCER RISK A considerable amount of knowledge regarding what causes cancer has accumulated during the past several decades. Cancer Biology has established the basic facts of the process, carcinogenesis, whereby a normal cell becomes a cancer cell. It has also come to be known that a considerable number of chemical substances are human carcinogens. Chemical carcinogens cause cancer by damaging the DNA of chromosomes. Damage occurs at the molecular level. One molecule of carcinogen attaches to the DNA molecule causing one increment of chromosomal damage, referred to as a lesion. Increased numbers of carcinogen molecules in the body increases the amount of damage done to the DNA. This means that reducing the amount of carcinogen one is exposed to reduces cancer risk. Genes are the basic functional units of chromosomes. Proteins that control all of the body s biochemical processes are produced using the genes for building instructions. When the gene that codes ...
Radiation - radiation that are high in energy can damage the bonds in DNA- this leads to mutations, ultraviolent radiation can cause skin cancer.. Carcinogens - carcinogens cause changes in DNA, DNA can be repaired by cells - it often takes lots of carcinogens before cancer is triggered. Carcinogens in cigarettes causes cancer, carcinogens in alcohol can cause cancer.. Ageing - older people have been exposed to more factor that cause cancers, they have also more time to accumulate damage DNA. Heredity - some people inherit genes which make them more likely to develop cancer.. Viruses - some viruses cause cancer, viruses infect cells by inserting new genetic materials into cells - cause changes in cells DNA.. ...
Differential gene expression during multistage carcinogenesis.: The use of the mouse skin multistage model of carcinogenesis has aided our understanding of crit
Get Carcinogen latest information and updates. Read latest Carcinogen articles, watch Carcinogen videos and much more at NDTV Food
Firefighters should assume carcinogens are present during suppression and overhaul activities and take appropriate actions during and after the incident.
An ingredient in soda, 4-methylimidazole, is a potential carcinogen and people who drink one or more can of soda per day could be exposed to it, increasing their risk of cancer.
MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. in the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinorna carcinogenesis, including its association with Helicobacterpylori (Hpylorl) and clinical applications. (c) 2008 the WIG Press. All rights reserved ...
AND THE SAME CARCINOGEN THAT PROMPTED A JULY RECALL OF SEVERAL BLOOD PRESSURE MEDICATIONS- HAS BEEN FOUND IN AN OVER THE COUNTER HEARTBURN MEDICINE. THE FOOD AND DRUG ADMINISTRATION SAYS THE DRUG ZANTAC AND ITS GENERIC SISTERS CONTAIN SMALL AMOUNTS OF A SUBSTANCE KNOWN AS N-D-M- A. AN F-D-A SPOKESWOMAN TOLD U-S-A TODAY THE DISCOVERY ISNT PROMPTING A RECALL… AND ADDS THAT PEOPLE SHOULDNT PANIC, BUT THE AGENCY SAYS ITS A GOOD IDEA TO SWITCH TO ANOTHER OVER-THE- COUNTER DRUG FOR THE TIME BEING. THOSE ON A PRESCRIPTION VERSION SHOULD TALK TO THEIR DOCTOR OR PHARMACIST. FINALLY SOME COOLER CHANGE IS COMING THANKS TO A COOL FRONT ...
Sorof, S and Dickens, M S., "Evidence for similar principal target proteins of chemical carcinogens in six carcinogen-organ systems. Abstr." (1978). Subject Strain Bibliography 1978. 443 ...
US FDA has warned pregnant women and children starting on to keep away from Pfizer s Viracept as a potential human carcinogen has been found in batches of the drug.
Immunocytochemical and biochemical analysis of the intermediate filaments of the hepatocytes in the chemical carcinogen-induced hyperplastic liver nodules of rats. (1990 ...
18+) *LEGAL MEDICAL CANNABIS PATIENT* *I MIS-SPOKE AT THE BEGINNING OF THE VIDEO, THE TITLE IS CORRECT* I saw this myth the other day .... ...
Several studies have shown that persistent infections and inflammation can favour carcinogenesis. At the same time, certain types of pathogens and anti-tumour immune responses can decrease the risk of tumourigenesis or lead to cancer regression. Infectious agents and their products can orchestrate a wide range of host immune responses, through which they may positively or negatively modulate cancer development and/or progression. The factors that direct this dichotomous influence of infection-mediated immunity on carcinogenesis are not well understood. Even though not universal, several previous reports have investigated the inverse link of pathogen-induced "benign" inflammation to carcinogenesis and various other pathologies, ranging from autoimmune diseases to allergy and cancer. Several models and ideas are discussed in this review, including the impact of decreased exposure to pathogens, as well as the influence of pathogen load, the timing of infection and the type of instigated immune ...
Despite the extensive work being performed to understand cancer and carcinogenic properties of chemicals and other agents, there are still gaps in our ability t...
Perth researchers have completed a comprehensive study into Australian workers and their exposure to ultraviolet radiation - a known human carcinogen.
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Table 8-1 lists definitions of terms commonly used in discussing chemical carcinogenesis. For benign neoplasms, the tissue of origin is frequently followed by the suffix "oma"; e.g., a benign fibrous neoplasm would be termed fibroma, and a benign glandular epithelium termed an adenoma. Malignant neoplasms from epithelial origin are called carcinomas, whereas those derived from mesenchymal origin are referred to as sarcoma. Thus, a malignant neoplasm of fibrous tissue would be a fibrosarcoma, whereas that derived from bone would be an osteosarcoma. ...
An environmental watchdog group said that Pepsi still contains dangerous levels of a carcinogen, a chemical that can cause cancer.
The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses ...
LONDON >> 1 of the worlds most preferred weed-killers -- and the most broadly employed sort in the U.S. -- has been labeled a probable carcinogen by the International Agency for Analysis on Cancer. News on NewsHub.org
Their research work has focused on an important enzyme, glutation transferase, which participates in the detoxification of the body from carcinogenic substances. The enzyme is made up of two identical protein structures that are joined by a contact similar to a key that fits a lock. The key is an amino acid that fits a cavity in the neighboring protein structure. In their work, the key has been replaced by artificial amino acids. Some exchanges yielded a fully active enzyme, while others did not.. The current study is a molecular equivalent to a hip joint operation, where the natural joint is replaced by an artificial part that is more robust. With the same methodology it is also possible not only to replace natural structures and functions but also to give proteins entirely new properties. Using simple chemistry, the twenty existent amino acids can be exchanged for hundreds of new chemical structures. In this way new proteins can be created with building blocks far beyond the limits of the ...
Working in viruses of aquaculture we have a number of raggedy primary monocultures that we have been tiptoeing around in the hopes of getting a cell line for routine use in screening.Are there any methods involving growth enhancing chemicals or carcinogens that may help speed this process up? Thanks , Steve and Jane ...
You can still enjoy summer barbecues and drastically reduce the level of grilling carcinogens in your meat by following a few science-backed tricks.
Shell and Dow hid a cancer-causing chemical in two commonly-used pesticides that contaminated the drinking water of millions of people across 13 states, according to several lawsuits collected by the Environmental Working Group.
Sugar feeds cancer cells, helping them to grow and multiply quickly, supporting the theory most cancers are a metabolic disease and not a genetic problem.
This proposal studies the mechanisms by which cells respond to DNA damaging agents. A specialized technology developed early in this project will be used to def...
News Analysis Scientists Continue to Use Outdated Methods The use of underperforming computational tools is a major offender in sciences reproducibility crisis-and theres growing momentum to avoid it.. ...
More than half a century has elapsed since the carcinogenic effects of radiation were first recorded. Study of such effects has since received continuing impetus from the early and expanding uses of...
Presents information describing investigations of molecular aspects of the mechanisms involved in chemical, physical, and viral (biological) carcinogenesis
Thank you for submitting a letter asking the government of Ontario to label carcinogens on household products to protect the health of Canadians. Help spread the word by sharing this action on Facebook and Twitter or emailing it to your contacts. For more updates on our work on toxic chemicals, subscribe to the Kicking Out Toxics quarterly newsletter.. Our work is possible thanks to caring people like you. Please make a charitable gift today in support of our environment!. Donate ...
Although the short-term health effects of formaldehyde exposure are well known, less is known about its potential long-term health effects. In 1980, laboratory studies showed that exposure to formaldehyde could cause nasal cancer in rats. This finding raised the question of whether formaldehyde exposure could also cause cancer in humans. In 1987, the U.S. Environmental Protection Agency (EPA) classified formaldehyde as a probable human carcinogen under conditions of unusually high or prolonged exposure (1). Since that time, some studies of humans have suggested that formaldehyde exposure is associated with certain types of cancer. The International Agency for Research on Cancer (IARC) classifies formaldehyde as a human carcinogen (2). In 2011, the National Toxicology Program, an interagency program of the Department of Health and Human Services, named formaldehyde as a known human carcinogen in its 12th Report on Carcinogens (3). ...
Scientists and environmentalists have been saying for decades that the worlds most common weed killer, glyphosate, also known as Monsantos Roundup, is a carcinogen. Last week, a World Health Organization report indicated that, indeed, glyphosate is a "probable carcinogen." Now theres evidence that the Environmental Protection Agency knew glyphosate was a probable carcinogen thirty years ago, but approved it for use anyway. Heres a summarized chronology of events: 1985: The Environmental Protection Agency (EPA) was aware of the herbicides ability to cause cancer 30 years ago, even categorizing it as a Class C Carcinogen." Class C carcinogens have "suggestive evidence of carcinogenic potential." 1991: The EPA already had evidence of multiple studies showing glyphosate is a possible carcinogen, but still reversed its decision suggesting that suddenly, six years later, t... Full article: http://www.care2.com/greenliving/epa-classified-roundup-a... ...
Quantitative Risk Assessment. July 1, 2014. Concept Definitions. Hazard - An intrinsic chemical, physical, societal, economic or political condition that has the potential for causing damage to a risk receptor (people, property or the environment). Slideshow 5801895 by wolfe
Returning to the United States in 1980 at the behest of Dr. David Rall, he joined the National Institute of Environmental Health Sciences and the National Toxicology Program. Dr. Huff was the first person hired by Dr. Rall, primarily to help establish the newly created NTP into a world-renowned scientific and public health-oriented program. He was a lead person for the transition of the bioassay program from the National Cancer Institute to the NTP. Dr. Huff introduced and established the NTP levels of evidence of carcinogenicity for the experimental chemical carcinogenesis bioassays for evaluating results, and as still utilized in the bioassay technical reports. While with the NTP he wrote or led the preparation and evaluation of more than 200 carcinogenesis bioassay technical reports. Along with Dr Hans Falk and later joined by Dr Vladimer Vouk, Dr Huff helped establish the Congressionally mandated NTP Report on Carcinogens, now in its 10th edition, into a science-based and globally accepted ...
A large number of substances that occur naturally in foods are carcinogenic (cancer-causing) when evaluated by the criteria scientists customarily use to assess the cancer-causing potential of synthetic substances. Other carcinogens are produced by cooking and by the actions of microorganisms. These natural carcinogens are more numerous, more widespread and in some cases more
WASHINGTON - Citing a strong body of peer-reviewed evidence, Environmental Working Group (EWG) today asked the National Toxicology Program (NTP) of the National Institutes of Health (NIH) to list fluoride in tap water in its authoritative Report on Carcinogens, based on its ability to cause a rare form of childhood bone cancer, osteosarcoma, in boys. The Report on Carcinogens lists only substances that are known or reasonably anticipated to cause cancer in humans.. In recent years, concerns have grown about the safety of fluoride in tap water. In 2002, the Environmental Protection Agency (EPA) commissioned a study by the National Research Council (NRC) on the overall safety of fluoride in tap water. The final report is expected by February 2006. The NRC, however, does not have the expertise or the mandate to determine the carcinogenicity of fluoride.. EWG recognizes the value of fluoride to dentistry, yet a substantial and growing body of peer-reviewed science strongly suggests that adding ...
Preservatives Bronopol, often listed as 2-bromo-2-nitropropane-1,3-diol, can contribute to the formation of cancer-causing nitrosamines, according to the FDA. It can also break down to produce formaldehyde (see below). Formaldehyde, found in eye shadows, mascaras and other cosmetics, is "reasonably anticipated to be a human carcinogen," according to the National Toxicology Programs "Ninth Report on Carcinogens" (January 2001)**. The EPA classifies it as a probable human carcinogen. In its liquid state, formaldehyde, present in the ingredients DMDM hydantoin, diazolidinyl urea imidazolidinyl urea and quaternium-15, can be absorbed through the skin and nails. As a volatile organic compound, or VOC, formaldehyde evaporates when the product is wet; levels drop sharply once its dry. Consumer concern has led many manufacturers to remove it from their nail polishes. Health Problems: Breathing formaldehyde fumes has been associated with many types of cancers, including those of the nose and throat. ...
A population-based case-control study was performed in South-West Germany in 1987/88 with 115 histological confirmed glioma and 81 meningioma cases and 418 randomly selected controls. On the basis of information from a food-frequency questionnaire and questions on food preparation and food supply, the role of dietary carcinogens, in particular...
We evaluated the patterns of sialylation on fibrosarcoma cell lines arising following 3-methylcholanthrene treatments of wild-type and IL-1alpha-deficient mice; the former induced progressive tumors, whereas the latter cell lines induced regressing tumors or failed to develop into tumors in mice due to immune rejection. In regressing tumors, terminating alpha2-6-Neu5Ac residues were present at lower levels than in progressively growing tumors. In both tumor cells, the amount of alpha2-6-Neu5Ac residues was higher by an order of magnitude relative to the amount expressed in primary fibroblasts harvested from IL-1alpha-deficient and wild-type mice. We focused on membrane proteins, which may interact with the immune system. Interestingly, HSP65, grp75, and gp96 were found on the surfaces of malignant cells and were shown to possess sialylated N-glycans. The amount of trisialylated glycans on gp96 and HSP65 and monosialylated glycans on grp75 of regressing cells was significantly lower than in ...
In the most recent version of the National Toxicology Programs Report on Carcinogens, two new substances have been classified as "known human carcinogens" and six others have been classified as... Continue Reading ...
Carcinogenesis involves the accumulation of genetic changes within a single cell. Tumor promotion functions in the initial clonal expansion of an initiated cell but is generally not considered to influence later stages. To investigate whether tumor promotion can influence later stages of carcinogenesis we developed a two-hit 7,12-dimethylbenz[a]anthracene (D) protocol designed to enrich for keratinocytes that contain at least two D-induced genetic alterations. FVB/N mice were initiated with D and promoted with 12-O-tetradecanoylphorbol-13-acetate (T) or treated with acetone (A) vehicle for 6 weeks. At 7 weeks after the start of promotion, but before visible papilloma development, groups of mice were treated with a second dose of D or A and 1 week later T promotion was resumed. D/T/A/T mice developed 2.8 papillomas/mouse and D/A/D/T mice demonstrated an additive tumor response and developed 5.8 papillomas/mouse. Importantly, D/T/D/T mice developed 12.4 papillomas/mouse, thereby demonstrating a ...
The tobacco-specific N-nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), as well as the Areca-derived N-nitrosoguvacoline (NG) were assayed for carcinogenicity in male F344 rats by lifetime administration in the drinking water. Groups of 30 to 80 rats were treated with 0.5 ppm, 1.0 ppm, or 5.0 ppm of NNK; 5.0 ppm of NNAL, 20 ppm of NG, a mixture of 20 ppm of NG and 1 ppm of NNK, and water only in the control group. The approximate total doses of the nitrosamines (mmol/kg of body weight) in these groups were: NNK, 0.073, 0.17, and 0.68; NNAL, 0.69; NG, 4.1; NG and NNK, 4.1 and 0.17. As in previous assays in which NNK was tested by s.c. injection, the lung was its principle target organ. Lung tumor incidences in the 0.5-, 1.0-, and 5.0-ppm groups were nine of 80, 20 of 80, and 27 of 30 compared to six of 80 in the control rats. This trend was significant, P , 0.005. Significant incidences of nasal cavity and liver tumors ...
The book "Carcinogen" contains a collection of reviews and original papers which illustrate: Models of Carcinogenesis - a review focused on the role of stem cells as target to carcinogenesis Tests for Detection of Carcinogens - one of the reviews describes different methods for analyzing nucleic acid adducts, while the other describes the Ty1 retrotransposition short-term test, which can be used to study carcinogenicity of chemicals, including such applied in agriculture, nutrition and pharmacy. The test is highly sensitive, selective to carcinogenic substances, and can be used to control environmental pollution ...
The handbook provides instructions for conducting the cancer hazard evaluation and preparing the monographs on substances under evaluation.. ...
Date: Mon, 15 Mar 93 12:00:25 EST From: bszymcz%ulysses at relay.nswc.navy.mil (Bill Szymczak) Subject: re: beer, root beer and cancer In HBD1095 John Sampson brought to our attention a very interesting article appearing in Science, (vol. 258 pg 261) on natural vrs. synthetic carcinogens. The fact that wine and beer were at the top of the list alerted me to read the article myself. In that article Rodent Carcinogens: Setting Priorities, the authors try to support their hypothesis that naturally occuring chemicals have not been as rigorously tested as synthetic chemicals for being potential carcinogens. This was done by using an index (HEPR) measuring the percent of the equivalent (by weight) amount of daily lifetime rat dosage required to halve cancer free rats at the end of a standard lifetime. Some of the values are: HEPR (%) HUMAN EXPOSURE (PER DAY) RAT CARCINOGEN 4.7 Wine (250ml) Ethanol (30 ml) 2.8 Beer (12 oz; 354 ml) Ethanol (18 ml) 0.3 Lettuce, 1/8 head (125 g) Caffeic acid (66.3 mg) ...
Heres some more info: carcinogens are commonly radioactive. In this case, it is not the substance itself, but the gamma and alpha radiation that the substance releases (forms of high frequency light) that cause the cell damage. This makes cigarettes and alcoholic beverages particularly dangerous because of the high levels of radiation that they contain.. Beyond chemical carcinogens, there are several microbial agents that are known carcinagens. HPV (Human Paploma Virus, the virus that causes warts) and Hepititus B are examples.. There are also a multitude of carcinogens that naturally form on meat cooked at high temperatures (grilling or broiling for example).. ...
Lede / California water officials today approved regulations to limit the level of a chemical experts say is a potent cancer-causing agent in the states water supply.The State Water Resources Control Board will limit the level of 1,2,3 TCP, or trichloropropane to five parts per trillion. Vic Bedoian reports from Fresno ...
Many human carcinogens are environmental carcinogens, for example, polychlorinated biphenyls (PCBs) from transformers. Other known carcinogens are tobacco smoke, aflatoxins (produced by moldy peanuts), sunlight (increase in malignant melanoma and squamous cell carcinoma), radiation, chemicals, dioxin, and benzene. Most authorities believe that the herpes viruses and papillomaviruses have a potential for producing cancerous changes. Patients with a history of certain diseases, such as hepatitis, have a higher incidence of liver cancer than patients without such history.. Normal cells have a mechanism to turn off cell growth with certain signals. In cancer, however, a change in the cells occurs so that they continue to grow. With a lack of control (switch does not turn off), the abnormal neoplastic cells continue to grow. The cell-surface antigens appear similar to the normal fetal types, so the body does not mount an immune response. The tumor stem cells have chromosomal abnormalities, ...
The following lists were compiled by the International Agency for Research on Cancer (IARC) and the US National Toxicology Program (NTP). These are long lists, and a lot of them you probably know about already, but some might be a surprise. The two that really stuck out for me were Mineral Oil (you know, BABY OIL!) and Tamoxifen. It really bothers me that the drug they put most breast cancer patients on, in an attempt to prevent recurrence of breast cancer, is a known carcinogen. I opted not to take it. That said, I dont blame anyone for taking it. Breast cancer is a really scary thing to be diagnosed with, and if were told something will help prevent it from coming back, it makes sense to take it. When I studies the side effects, and started to understand how it works in our bodies, it made more sense in my opinion, to refuse it.. **Please note: My decision not to use Tamoxifen should in no way be viewed as a recommendation for someone else not to take it. I did a lot of research, and talked ...
DESCRIPTION (provided by applicant): Tobacco-smoking is the single major cause of cancer mortality in the US, and is a risk factor for a number of cancers including lung, upper aero-digestive tract, bladder and pancreas. One of the most powerful carcinogens in tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK is bioactivated to potent electrophiles that react to form methyl and 4-(3-pyridyl)-4-oxobutyl (POB) DNA adducts. Role of methyl-DNA adducts in carcinogenesis have been well characterized and the current paradigm is that methyl- DNA adducts are more important than POB-DNA adducts in the etiology of tobacco-induced cancers. However, recently it was found that O2-POB-dT adduct is the most persistent POB adduct in NNK-treated rodents. Our preliminary results show that O2-POB-dT is inefficiently repaired in human cells and is mutagenic in SOS-induced E. coli and mammalian cells. The objective of this application is to determine the mechanisms by which O2-POB-dT forms ...
The impact assessment (IA) accompanying the proposal for a third revision of the carcinogens and mutagens Directive 2004/37/EC clearly defines the problem to be addressed. However, it would have benefited from providing more comprehensive explanations of its evolution without EU action. The objectives appear to be relevant, sufficiently measurable, achievable, though not time-bound. The IA considers a wide range of options, and those retained for further assessment appear to be reasonable, and consistent with the approach followed in two previous amendments of the directive. The analysis of impacts focuses on the economic and social dimension, mainly health, consistently with the manner in which the problem has been defined. Environmental impacts are assessed to be broadly negligible: considering that the IA is dealing with carcinogenic chemical substances, this would have perhaps required further justification. The IA acknowledges a general issue regarding, inter alia, the availability of data on the
According to WebMD (ew, I know) Aloe Vera contains lectins and aloin, which is a potential carcinogen but only in rats. Aloe as a human carcinogen has
PubMed journal article Heterocyclic amines: human carcinogens in cooked food? were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Conversion Technology has over 33 years of conducting risk assessments and working with multiple industry sectors to ensure compliance and keeping workers safe. www.conversiontechnology.com
Our expert team has vast experience in completing Qualitative Risk Assessments (QRAs) , which is a structured approach to identifying and understanding the risk associated with hazardous activities.
After the success of the events organized in February 2007 and in response to requests from users of the software, PIARC and Ineris have organized a new seminar and further training sessions in Paris, France, 26-28 January 2010.. ...
Whats that, you say? It seems hypocritical that Susan G. Komen for the Cure would create a perfume that contains potential carcinogens while simultaneously claiming to fight "every minute of every day to finish what we started and achieve our vision of a world without breast cancer"? Thats what Breast Cancer Action thinks, too. No amount of shopping for pink ribbon products will rid our world of the breast cancer epidemic. We need to change the conversation about breast cancer - to one that focuses on eliminating toxins from the personal care products that we use daily, and where we boldly call out pinkwashers for distracting us from the real work that needs to be done.. ...
Sucralose in e-liquids can break down, increasing toxic aldehydes in vapors and producing harmful organochlorines, including a potential carcinogen.
No it hasnt been banned, and it is probably safe to use. But no company with any sense will carry on using it.. What has happened is that it has been listed on a list of potential carcinogens. This means it is banned unless a committee called the SCCS upholds its use. They have looked at it and concluded that there is insufficient data to reach a conclusion. This leaves it in a bit of a legal limbo, and it might be banned at any minute. So if I were using it Id be switching to something else as quickly as I could.. This is a good example of why you need to know the background to something before making any decisions about it, and why you cant just look stuff up. If you were to read the EU cosmetic regulations youd see that it is listed as being fully legal. There is nothing so misleading as facts.. If you are in the business and thinking of using it in a product you are making I suggest you dont.. If you are wondering whether it is safe to use products you have already bought, Id be happy ...
Air fresheners get rid of noxious gas and pungent odors, but newest research has shown that they are also releasing fumes which are even more dangerous than cigarette smoke, and may lead to respiratory issues, such as asthma, and hormonal imbalance.. According to a study conducted by the Public Health Englands Center for Radiation, Chemical and Environmental Hazards, theres a "considerable" amount of formaldehyde in the content of common air fresheners, which enters the group of "known human carcinogen" by the United States National Toxicology Program.. Hence, the overexposure to air fresheners has been linked to nose and throat cancers. On the other hand, you can replace them with essential oils, and your home will smell pleasant, and you will also benefit from their use.. All you need to do is to add 10-15 drops of some essential oil to a cup of distilled water and spray the solution all over the house.. ...
Carcinogen: Carcinogen, any of a number of agents that can cause cancer in humans. They can be divided into three major categories: chemical carcinogens (including those from biological sources), physical carcinogens, and oncogenic (cancer-causing) viruses. Most carcinogens, singly or in combination, produce
The Rumsfeld Plague: Aspartame Brings Horror by Hesh Goldstein (NaturalNews) The aspartame horror began in 1981 due to Donald Rumsfeld, as head of the G.D. Searle pharmaceutical company, when he used his political clout to put a known carcinogen on the market to poison a nation all in the name of money. In a Washington…
ANAHEIM, Calif-Although toxicology and epidemiology have both contributed importantly to our understanding of cancer hazards, researchers have now
ORCID: 0000-0001-8562-4944, Williams, J. A., Cole, Kathleen J., Muir, Gordon H., Grover, Philip L. and Phillips, David H. (2000) Susceptibility of primary cultures of human prostate epilthelial cells to chemical carcinogens as detected using the Comet assay. Mutagenesis, 15 (5). p. 447. ISSN 0267-8357 Full text not available from this repository.. Official URL: http://dx.doi.org/10.1093/mutage/15.5.431. ...