Looking for online definition of carboxylesterase 2 in the Medical Dictionary? carboxylesterase 2 explanation free. What is carboxylesterase 2? Meaning of carboxylesterase 2 medical term. What does carboxylesterase 2 mean?

TY - JOUR. T1 - Deletions of the esterase D locus from a survey of 200 retinoblastoma patients. AU - Cowell, J. K.. AU - Rutland, P.. AU - Jay, Marcelle. AU - Hungerford, J.. PY - 1986/2. Y1 - 1986/2. N2 - Esterase D levels from 200 retinoblastoma patients have been measured in an attempt to identify individuals carrying deletions of chromosome region 13q14. In this series 75% had bilateral tumours and 23% were familial. Of nine patients identified as having low esterase D levels, five had not previously been diagnosed as deletion carriers. These observations demonstrate the benefit of screening retinoblastoma populations for esterase D deficiency.. AB - Esterase D levels from 200 retinoblastoma patients have been measured in an attempt to identify individuals carrying deletions of chromosome region 13q14. In this series 75% had bilateral tumours and 23% were familial. Of nine patients identified as having low esterase D levels, five had not previously been diagnosed as deletion carriers. These ...

Any risk of strain JPL-2, with the capacity of degrading fenoxaprop-P-ethyl (FE), was isolated from the soil of the wheat line of business and defined as JPL-2, FE -hydrolyzing carboxylesterase gene Introduction Fenoxaprop-ethylethyl-2-(4-((6-chloro-2-benzoxazolyl)oxy) phenoxy) propanoate) (FE) is normally a representative of aryloxyphenoxy propanoate (AOPP) herbicides. their matching acid type (Nie sp. B2 could degrade clodinafop propargyl (CF) to clodinafop acidity and 4-(4-Chloro-2-fluoro-phenoxy)-phenol (Singh, 2013). In summary, step one in the degradation of AOPP herbicides, which is normally distributed among these strains, may be the break down of the carboxylic acidity ester bond with a carboxylesterase. Far Thus, just two genes encoding this enzyme have already been cloned: from QDZ-1 and from sp. T1. Nevertheless, the features of FeH possess yet to become investigated. In this study: JPL-2, an aryloxyphenoxy propanoate (AOPP) herbicide-degrading strain of was cloned and expressed; and ...

Carboxylesterases hydrolyze numerous endogenous and foreign compounds with diverse structures. Humans and rodents express multiple forms of carboxylesterases, which share a high degree of sequence identity (∼70%). Alignment analyses locate in carboxylesterases several functional subsites such the catalytic triad as seen in acetylcholinesterase. The aim of this study was to determine among human and rodent carboxylesterases the immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, tissue distribution, and tumor-related expression. Six antibodies against whole carboxylesterases or synthetic peptides were tested for their reactivity toward 11 human or rodent recombinant carboxylesterases. The antibodies against whole proteins generally exhibited a broader cross-reactivity than the anti-peptide antibodies. All carboxylesterases hydrolyzed para-nitrophenylacetate and para-nitrophenylbutyrate. However, the relative activity varied markedly from ...

cell wall, extracellular region, acylglycerol lipase activity, carboxylic ester hydrolase activity, short-chain carboxylesterase activity, medium-chain fatty acid catabolic process, monoacylglycerol catabolic process, short-chain fatty acid catabolic process

https://doi.org/10.18632/oncotarget.23619 Dominique Lombardo, Françoise Silvy, Isabelle Crenon, Emmanuelle Martinez, Aurélie Collignon, Evelyne Beraud, Eric Mas

Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identified the monoclonal antibodies that bind to overlapping and independent epitopes on human BChE. The nucleotide and amino acid sequences of 4 monoclonal antibodies are deposited in GenBank. Our goal was to determine which of the 5 monoclonal antibodies recognize BChE in the plasma of animals. Binding of monoclonal antibodies 11D8, B2 18-5, B2 12-1, mAb2 and 3E8 to BChE in animal plasma was measured using antibody immobilized on Pansorbin cells and on Dynabeads Protein G. A third method visualized binding by the shift of BChE activity bands on nondenaturing gels stained for BChE activity. Gels were counterstained for carboxylesterase activity. The three methods agreed that B2 18-5 and mAb2 have broad species specificity, but the other monoclonal antibodies interacted only with human BChE, the exception being ...

Port Phillip Bay, Australia, is a large semi-closed bay with over four million people living in its catchment basin. The Bay receives waters from the Yarra River which drains the city of Melbourne, as well as receiving the discharges of sewage treatment plants and petrochemical and agricultural chemicals. A 1999 study demonstrated that fish inhabiting Port Phillip Bay showed signs of effects related to pollutant exposure despite pollution management practices having been implemented for over a decade. To assess the current health status of the fish inhabiting the Bay, a follow up survey was conducted in 2015. A suite of biomarkers of exposure and effects were measured to determine the health status of Port Phillip Bay sand flathead (Platycephalus bassensis), namely ethoxyresorufin-O-deethylase (EROD) activity, polycyclic aromatic hydrocarbons (PAH) biliary metabolites, carboxylesterase activity (CbE) and DNA damage (8-oxo-dG). The reduction in EROD activity in the present study suggests a ...

Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood. Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites-benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaines metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, rather than undergoing hydrolysis with water, which results in the production of cocaethylene. cocaine + H2O → benzoylecgonine + methanol (with liver carboxylesterase 1) benzoylecgonine + ethanol → ...

Carboxylesterases play an important role in the metabolism of endogenous compounds and exogenous substances such as drugs (including prodrugs), pesticides, and herbicides. Carboxylesterases are widely distributed in the microsomes of the several tissues such as liver, kidney, brain, and lung, where they are loosely bound to the luminal surface of the ER. The highest concentration of carboxylesterases is found in the liver microsomes (Morgan et al., 1994). Furthermore, it has been reported that secretory form such as serum carboxylesterase is highly expressed in rodent (Yan et al., 1995b). Therefore, the in vivo hydrolysis of drug containing ester moiety depends on hydrolase activity in the tissues as well as the blood.. Taking into account the drug disposition after administration, hydrophilic drugs are mainly distributed to the systemic blood circulation, whereas hydrophobic drugs distribute in several tissues. The hydrophobicity and basicity of butyryl-PL strongly suggest that butyryl-PL is ...

Acetylcholinesterase (HGNC symbol ACHE), also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE is a hydrolase that hydrolyzes choline esters. It has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules of acetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. The active site of AChE comprises 2 subsites - the anionic site and the esteratic subsite. The structure and mechanism of action of AChE have been elucidated from the crystal structure of the enzyme. ...

Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, except cel5D. The location of the transcription initiation sites was determined using RT-PCR and the mRNA 5′-end extremities were detected using primer extension experiments. Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. To test this hypothesis in vivo, an insertional glyR2 mutant ...

A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl) benzothiazole (HMBT) has been developed for selective monitoring of human carboxylesterase 1 (hCE1). The probe is designed by introducing benzoyl moiety to HMBT. The prepared latent spectroscopic probe 1 displays satisfying stability under physiological pH conditions with very low background signal. Both the reaction phynotyping and chemical inhibition assays demonstrated that hCE1 mediated the specific cleavage of the carboxylic ester bond of probe 1 in human biological samples. The release of HMBT leads to a remarkable red-shifted emission in fluorescence spectrum (120 nm large emission shift). Furthermore, human cell-based assays show that probe 1 is cell membrane permeable, and it can be used for bioassay and cellular imaging of hCE1 activity in HepG2 cells. These findings lead to the development of a simple and sensitive fluorescent method for measurement of hCE1 activity in vitro or in living cells, in the ...

Background The main toxicity of irinotecan in advanced colorectal cancer (CRC) is delayed diarrhoea. Intestinal SN-38, released by deconjugation of the parent glucuronide excreted into the bile or produced in situ by intestinal carboxylesterase, is toxic to the intestinal epithelium. The canalicular transport of irinotecan and SN-38G is mediated by ABCC2 (MRP2) and ABCB1 (MDR1) which are both inhibited by ciclosporin. We tested whether irinotecan and ciclosporin was non-inferior for anti-cancer efficacy and superior for toxicity compared with single-agent irinotecan. Methods Six hundred and seventy-two patients with advanced, measurable CRC following prior fluoropyrimidine- containing chemotherapy were randomised to either irinotecan 3-weekly 350 mg/m 2 (or 300 mg/m 2 if age | 70 or performance status (PS) = 2) or 3-weekly irinotecan at 140 mg/m 2 (120 mg/m 2 if age | 70 or PS = 2) with ciclosporin 3 mg/kg t.d.s. for three days by mouth starting on the morning before irinotecan. The primary end

Background The main toxicity of irinotecan in advanced colorectal cancer (CRC) is delayed diarrhoea. Intestinal SN-38, released by deconjugation of the parent glucuronide excreted into the bile or produced in situ by intestinal carboxylesterase, is toxic to the intestinal epithelium. The canalicular transport of irinotecan and SN-38G is mediated by ABCC2 (MRP2) and ABCB1 (MDR1) which are both inhibited by ciclosporin. We tested whether irinotecan and ciclosporin was non-inferior for anti-cancer efficacy and superior for toxicity compared with single-agent irinotecan. Methods Six hundred and seventy-two patients with advanced, measurable CRC following prior fluoropyrimidine- containing chemotherapy were randomised to either irinotecan 3-weekly 350 mg/m2 (or 300 mg/m2 if age |70 or performance status (PS) = 2) or 3-weekly irinotecan at 140 mg/m2 (120 mg/m2 if age |70 or PS = 2) with ciclosporin 3 mg/kg t.d.s. for three days by mouth starting on the morning before irinotecan. The primary end-point was the

Cocaine is a carboxylesterase substrate predominantly eliminated by hydrolysis to BE and EME (Fig. 1) by CES1 and CES2 (Isenschmid et al., 1992; Dean et al., 1995; Kamendulis et al., 1996; Cone et al., 1998), and it is one of the few carboxylesterase substrates whose interaction with ethanol has been studied extensively. Studies of the effect of ethanol on cocaine pharmacokinetics have focused on the pharmacodynamic interaction in drug abuse and have reported on administration of cocaine by the intravenous, intraperitoneal, nasal, and smoking routes (Farré et al., 1993; Cami et al., 1998; Laizure et al., 2003). All of these routes of administration bypass the first-pass metabolism of cocaine either completely (intravenous and smoking) or partially (intraperitoneal and intranasal). These studies, performed in both humans and animal models, consistently demonstrate that the coadministration of ethanol inhibits the metabolism of cocaine given by nonoral (intravenous, smoking, intraperitoneal, and ...

A scarce number of tests with terrestrial organisms are available for the category members of the Short Chain Alcohol Esters. As the category members of the Short Chain Alcohol Esters (SCAE) are readily biodegradable, ready degradation into metabolites is postulated. Fatty acids have been shown to have a low potential for bioaccumulation when considering biotransformation and the omnipresent activity of the enzyme carboxylesterase. Fatty acids and alcohols are the main metabolites of fatty acid esters. These components occur in soils naturally and are part of physiological pathways and can be used as energy source. The enzyme carboxylesterase is omnipresent in the environment. Bioaccumulation in organisms birds feed on are not expected. Furthermore, low toxicity to rats (repeated dose oral, NOAEL(90d) = 6000 mg/kg bw/d) was found. As a result, a low potential for secondary poisoning of birds is expected. Further testing should not be conducted due to animal welfare. ...

Non-P-glycoprotein-mediated multidrug-resistant C-A120 cells that overexpressed multidrug resistance protein (MRP) were 10.8- and 29.6-fold more resistant to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) and SN-38, respectively, than parental KB-3-1 cells. To see whether MRP is involved in CPT-11 and SN-38 resistance,MRP cDNA was transfected into KB-3-1 cells. The transfectant, KB/MRP, which overexpressed MRP, was resistant to both CPT-11 and SN-38. 2-[4-Diphenylmethyl)-1-piperazinyl]ethyl-5-(trans-4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide (PAK-104P) and MK571, which reversed drug resistance in MRP overexpressing multidrug-resistant cells, significantly increased the sensitivity of C-A120 and KB/MRP cells, but not of KB-3-1 cells, to CPT-11 and SN-38. The accumulation of both CPT-11 and SN-38 in C-A120 and KB/MRP cells was lower than that in KB-3-1 cells. The treatment with 10 μM PAK-104P increased the ...

Irinotecan (CPT-11) is now widely used as the first-line chemotherapy for mCRC. There were 4 key enzymes for CPT-11 metabolizing, CYP3A4, UDP-glucuronosyltransferase, carboxylesterase(CES), and ATP-binding cassette (ABC) transporters. Genetic variations of those enzymes may cause the heterogeneity in safety and efficacy of CPT-11. The aim of this study is to figure out the correlation between the genetic polymorphism and the drug response ...

4133 Individualized, tailored drug therapy is an important direction for development of cancer treatment. Currently, irinotecan (CPT-11) has been widely used in a variety of human cancers. Occasionally, occurrence of unexpected severe toxicities (Gr. 4 neutropenia, Gr. 4 diarrhea, sepsis) of irinotecan may hinder its clinical use. Irinotecan is activated by carboxylesterase to SN-38 with its antitumor activity, and which has been associated with the severe diarrheal episodes as a result of the direct enteric injury. SN-38 undergoes glucuronide conjugation and inactivation by UDP-glucuronosyl transferase 1A1 (UGT1A1) isoform to form the inactive SN-38 glucuronide (SN-38G). Among the UGT1A1 polymorphism, the UGT1A1*28 genotype, with (TA)7TAA change of UGT1A1 gene promoter, had probable important implications to predict and monitor clinical toxicity induced by irinotecan. We tried to analyze the polymorphisms in UGT1A1*28 genotype as predictors of severe toxic events occurring after irinotecan ...

Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS. . ...

Expression of CES5A (CAUXIN, CES4C1, CES5, CES7, FLJ31547) in granulocytes tissue. Antibody staining with in immunohistochemistry.

Cat.-Nr: LS001141. A non-specific esterase partially purified to the 0.35-0.55 fraction by the method described by Singer, JBC, 174, 11 (1948). Also active as a... Read More ...

Découvrez les pièces détachées écrans pour Pièces détachées MacBook Pro 15 Retina Début 2013 sur Sosav spécialistes des pièces détachées, kits de réparation et accessoires de qualité pour la gamme Pièces détachées MacBook Pro 15 Retina Début 2013

Le Registre public des espèces en péril est une source complète dinformation publique sur des espèces en péril au Canada et la Loi sur les espèces en péril (LEP).

ISBN 9789898066343 - Get FREE shipping offers and dollar off coupons with our price comparison for Os Ces Nunca Mentem sobre o Amor Reflexes acerca do mundo emocional dos ces - ISBN 9789898066343, 9898066342.

Analyse bioinformatique des événements de transferts horizontaux entre espèces de drosophiles et lien avec la régulation des éléments transposables ...

Samsung's latest Creative Lab projects are shaping up to be some of their most innovative ideas yet. The projects, which will be shown off at CES next week, include the S-Ray portable directional speaker, the GoBreath lung damage recovery device…

Learn more about Parto por cesárea at Grand Strand Medical Center DefiniciónRazones para realizar el procedimientoPosibles complicaciones¿Qué...

CES 2017 took place from Jan 3-8th in Las Vegas. This years show was crazy big with interesting technology that has some unique potential.

Iriarte Corredora, Venta y arriendo de propiedades, administración de propiedades en arriendo, tasaciones de bienes raíces y terrenos.

Iriarte Corredora, Venta y arriendo de propiedades, administración de propiedades en arriendo, tasaciones de bienes raíces y terrenos.

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...

Abstract: The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the removal of an essential palmitoleate. Here we disclose two new chemical scaffolds that inhibit Notum enzymatic activity. Our approach was to create a fragment library of 250 acids for screening against Notum in a biochemical assay followed by structure determination by X-ray crystallography. Twenty fragments were identified as hits for Notum inhibition and 14 of these fragments were shown to bind in the palmitoleate pocket of Notum. Optimization of 1-phenylpyrrole 20, guided by structure-based drug design, identified 20z as the most potent compound from this series. Similarly, optimization of 1-phenylpyrrolidine 8 gave acid 26. This work demonstrates that inhibition of Notum activity can be achieved by small, drug-like molecules possessing favorable in vitro ADME ...

Expression of CES5A (CAUXIN, CES4C1, CES5, CES7, FLJ31547) in cerebellum tissue. Antibody staining with in immunohistochemistry.

Download Exterminez Toutes Ces Brutes ().pdf online, Author( s): Sven Lindqvist; Format: Book; Dimensions: x x 17mm , g. La colonne (Tome 2) - Exterminez-moi toutes ces brutes (French Edition) - Kindle on comiXology and on these devices; Due to its large file size, this book may. kurtzvetclinic.com: La colonne 2 Exterminez-moi toutes ces brutes (French Edition) ( ): Christophe Dabitch, Nicolas Dumontheuil: Books. Read Download Online Exterminez Toutes Ces Brutes!: GæɛņÄnocides By Sven Lindqvist download ebook PDF EPUB, book in english language. PDF Exterminez Toutes Ces Brutes Download Free. eBooks are electronic books that is formatted to fit many devices. There quite a lot of fine websites offering. Exterminez toutes ces brutes!: un voyage à la The dead do not die: Exterminate all the brutes and Terra Nullius. by Sven Lindqvist. eBook. English. Download Exterminez Toutes Ces Brutes ().pdf online, Author( s): Sven Lindqvist; Format: Book; Dimensions: x x 17mm , g. La colonne ...

All products sold and installed by CES are covered by factory warranties. The terms and conditions of these warranties vary from manufacturer to manufacturer. It is CESs commitment to honor and execute these warranties to their full extent where applicable. At all times,CES will strive to provide the swiftest, and most fair solutions to equipment warranty issues.. CES acts as an authorized factory representative for all warranty related claims. CES field personnel are not permitted to authorize warranty returns and claims at installation sites. Warranty determinations made at the job site may be subject to rejection or modification by the factory.. CES guarantees all labor for a period of one year from initial installation on equipment installed by CES personnel.. In cases where products are replaced by the factory, labor charges for removing and reinstalling equipment may be the customers responsibility and will be determined on a case by case basis.. Warranties do not cover cosmetic damage ...

All products sold and installed by CES are covered by factory warranties. The terms and conditions of these warranties vary from manufacturer to manufacturer. It is CESs commitment to honor and execute these warranties to their full extent where applicable. At all times,CES will strive to provide the swiftest, and most fair solutions to equipment warranty issues.. CES acts as an authorized factory representative for all warranty related claims. CES field personnel are not permitted to authorize warranty returns and claims at installation sites. Warranty determinations made at the job site may be subject to rejection or modification by the factory.. CES guarantees all labor for a period of one year from initial installation on equipment installed by CES personnel.. In cases where products are replaced by the factory, labor charges for removing and reinstalling equipment may be the customers responsibility and will be determined on a case by case basis.. Warranties do not cover cosmetic damage ...

Programme de rétablissement du naseux de Nooksack (Rhinichthys cataractae) au Canada; La Loi sur les espèces en péril (LEP) renforce et accroît la capacité du gouvernement du Canada de protéger les espèces et les sous-espèces sauvages;Le naseux de Nooksack est un petit poisson de moins de 15 cm, de la famille des cyprinidés (méné). Ce poisson élancé possède de larges nageoires pectorales et un long museau qui dépasse distinctement la bouche.

CPT-001 시험정보 최신버전 덤프샘플문제 다운, CPT-001시험은 영어로 출제되는 만큼 시험난이도가 많이 높습니다.하지만 CPT-001인증덤프만 있다면 아무리 어려운 시험도 쉬워집니다, GAQM CPT-001 시험정보 ITExamDump 는 관련 업계에서 저희만의 브랜드 이미지를 지니고 있으며 많은 고객님들의 찬사를 받고 있습니다, 하지만 지금은 시스템이 업그레이드되어GAQM CPT-001덤프를 결제하시면 바로 사이트에서 다운받을수 있습니다, GAQM CPT-001 시험정보 하지만 여러분의 선택에 따라 보장도 또한 틀립니다, 경쟁율이 치열한 IT시대에 CPT-001시험을 패스하여 자격증을 취득함으로 IT업계 관련 직종에 종사하고자 하시는 분들께는 아주 큰 가산점이 될수 있고 자신만의 위치를 보장할수 있으며 더욱이는 한층 업된 삶을 누릴수 있을수도 있습니다.

We spent the week walking the hallways of CES searching for the forward-thinking designs that will change our lives. Here are our favorite items from CES 2016.

Tigers consume more food and occupy a far larger space. Furthermore, smaller animals are somewhat more numerous than larger ones. You are earning a cladogram of

Apple is ditching MacWorld to instead exhibit at CES next year instead, according to one source. The source, citing friends who work at Apple, insisted

Im new here and seeking advice/insight. I just purchased a 79 L-5 CES which was apparently cased for most of the last 40 years. As a result, the celluloid pickguard gassed out from heat, corroding th

Amanda Congdon turns in some truly shocking coverage from CES, where she decides to test-drive the perp end of a personal taser. As painful as it looks, its only about half as wrenching as watching Amandas

An Audi A7 self-driving car prototype completed a trip of more than 550 miles from California to CES in Las Vegas on public roads.

We use cookies to deliver our services and to provide you with a personalized experience. By using our services, you agree to our use of cookies ...

A few years ago, Judie and I were at CES, and she turned me on to having a smoothie for breakfast. Most days since that time, Ive done just that. Now, thanks to the BlendJet and JetPacks, I can have a delicious smoothy anywhere. With the companys overpriced but delicious JetPacks, the process is even easier!. Read More ...

宏碁股份有限公司 宏碁推出採用Windows 10的全新創作者筆電ConceptD 3與ConceptD 3 Ezel。其中ConceptD 3 Ezel為可翻轉筆電，大大的擴展了ConceptD系列產品。甫獲2020年CES創新獎的ConceptD Ezel系列採用宏碁專利Ezel軸承設計，提供六種不同使用模式，讓設計師更方便協作、分享、實踐創意點子。ConceptD Ezel 系列皆採用宏碁的Ezel軸承，適合用於各式工作情境，不管是團隊協作、或使用產品隨附的Wacom® 或Acer Active Stylus觸控筆進行繪製或向客戶簡報都能游刃有餘。設計師可以將筆電轉換至手邊最合適的工作模式，包含分享、漂浮、站立、平板及展示和傳統筆電共六種模式可供選擇。ConceptD 系列輕便易攜帶，能在旅途中取代桌機，以一台裝置即可繪製、完成作品並呈現簡報的創作者來說是效能強大的移動式專業工作站，是絕佳選擇。