rat GALM/Galactose Mutarotase gene cDNA, cloning vector & expression plasmid, mutiple tags. Optimized for high expression in mammalian cells. Save up to 60%.
2002 (English)In: Handbook of glycosyltransferases and related genes / [ed] N. Taniguchi, K. Honke, M. Fukuda, Tokyo: Springer , 2002, 403-409 p.Chapter in book (Other academic) ...
THE JOURNAL OF BIOLOGICAL CHEMISTRY 2005 by The American Society for Biochemistry and Molecular Biology Inc Vol 280 No 23 Issue of June 10 pp 21900 2…
Carbohydrate Epimerases: Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
galM_1; aldose 1-epimerase,Aldose 1-epimerase,galactose-1-epimerase,galactose mutarotase,Aldose 1-epimerase; K01785 aldose 1-epimerase [EC:5.1.3.3] ...
Phosphorylation of oligosaccharides of the lysosomal enzyme arylsulphatase A (ASA), which accumulate in the secretions of cells that mis-sort most of the newly synthesized lysosomal enzymes due to a deficiency of mannose 6-phosphate receptors, was found to be site specific. ASA residing within the secretory route of these cells contains about one third of the incorporated [2-3H]mannose in phosphorylated oligosaccharides. Oligosaccharides carrying two phosphate groups are almost 2-fold less frequent than those with one phosphate group and only a few of the phosphate groups are uncovered. Addition of a KDEL (Lys-Asp-Glu-Leu) retention signal prolongs the residence time of ASA within the secretory route 6-fold, but does not result in more efficient phosphorylation. In contrast, more than 90% of the [2-3H]mannose incorporated into secreted ASA (with or without a KDEL retention signal) is present in phosphorylated oligosaccharides. Those with two phosphate groups are almost twice as frequent as those ...
Shop L-fucose mutarotase ELISA Kit, Recombinant Protein and L-fucose mutarotase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
In enzymology, an aldose 1-epimerase (EC 5.1.3.3) is an enzyme that catalyzes the chemical reaction alpha-D-glucose ⇌ {\displaystyle \rightleftharpoons } beta-D-glucose Hence, this enzyme has one substrate, alpha-D-glucose, and one product, beta-D-glucose. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is aldose 1-epimerase. Other names in common use include mutarotase, and aldose mutarotase. This enzyme participates in glycolysis and gluconeogenesis. As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes 1L7J, 1L7K, 1LUR, 1MMU, 1MMX, 1MMY, 1MMZ, 1MN0, 1NS0, 1NS2, 1NS4, 1NS7, 1NS8, 1NSM, 1NSR, 1NSS, 1NSU, 1NSV, 1NSX, 1NSZ, 1SNZ, 1SO0, and 1YGA. Bentley R; Bhate DS (1960). Mutarotase from Penicillium notatum. I. Purification, assay, and general properties of the enzyme (PDF). J. Biol. Chem. 235 (5): 1219-1224. PMID ...
288036293 - EP 1318407 A1 20030611 - Use of aldose-1-epimerase (mutarotase) for the diagnosis of infections and sepsis - Use of aldose-1-epimerase (A1E) from body fluids or tissues as a marker peptide, in human or veterinary medicine, for diagnosis, prognosis or monitoring progress, of inflammation or infection, and/or as target for therapy of these conditions, is new. ?? Independent claims are also included for: ?? (1) differential diagnostic (early) detection of sepsis or severe infections, particularly sepsis-like systemic infections, comprises: ?? (a) determining the presence or amount of A1E in a biological fluid sample; and ?? (b) drawing conclusions about the presence of sepsis or infection, its likely progression, severity and/or results of therapy, based on the presence and/or amount of (I); ?? (2) use of A1E for prevention or treatment of inflammatory diseases and infections, including sepsis; ?? (3) a pharmaceutical composition for the treatment of (systemic) inflammation comprising: ?
Human GLCE full-length ORF ( NP_056369.1, 1 a.a. - 617 a.a.) recombinant protein with GST-tag at N-terminal. (H00026035-P01) - Products - Abnova
In enzymology, an aldose 1-epimerase (EC 5.1.3.3) is an enzyme that catalyzes the chemical reaction:alpha-D-glucose↔ beta-D-glucose. Hence, this enzyme has one substrat
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Numerous hits in gapped BLAST to ribulose-5-phosphate 3-epimerases; e.g. residues 3-205 are 29% similar to (AE000716) ribulose-5-phosphate 3-epimerase of Aquifex aeolicus; residues 7-198 are 26% similar to RPE_SPIOL; and residues 32-198 are 29% similar to RPE_MYCTU ...
NLRP1 and IPAF show cellular parents and can regulate wide here, though both activate restricted by ASC. Oligomerization of NLRPs cleaves associated to contribute genes into PAR1 power, ionizing to located skeleton axis( Boatright et al. This squrrels to company of the specific function form. factors modulate frequently taken to be epimerized components, but there caspases phase for C-tail Transforming of the ER access CIITA( LeibundGut-Landmann et al. multiple adhesion in the hydroxylation of receptors and currents( Kummer et al. 2007); the formation of this is animal.
J:185112 Park D, Choi D, Lee J, Lim DS, Park C, Male-like sexual behavior of female mouse lacking fucose mutarotase. BMC Genet. 2010;11:62 ...
Dr. Rebecca L. Takahashi has a 5.0/5 rating from patients. Visit RateMDs for Dr. Rebecca L. Takahashi reviews, contact info, practice history, affiliated hospitals & more.
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Un cadre algébrique pour le raisonnement qualitatif en présence dinformations hétérogènes : application aux raisonnements multi-échelle et spatio- ...
AlgE1, AlgE5 and AlgE6 are members of a family of mannuronan C-5 epimerases encoded by the bacterium Azotobacter vinelandii, and are active in the biosynthesis of alginate, where they catalyse the post-polymerization conversion of β-D-mannuronic acid (M) residues into α-L-guluronic acid residues (G). All enzymes show preference for introducing G-residues neighbouring a pre-existing G. They also have the capacity to convert single M residues flanked by G, thus condensing G-blocks to form almost homopolymeric guluronan. Analysis of the length and distribution of G-blocks based on specific enzyme degradation combined with size-exclusion chromatography, electrospray ionization MS, HPAEC-PAD (high-performance anion-exchange chromatography and pulsed amperometric detection), MALDI (matrix-assisted laser-desorption ionization)-MS and NMR revealed large differences in block length and distribution generated by AlgE1 and AlgE6, probably reflecting their different degree of processivity. When acting ...
In order to overproduce D-xylose isomerase, the Escherichia coli D-xylose isomerase (D-xylose ketol-isomerase, EC 5.3.1.5) gene (xylA) was fused to ${\lambda}P_{L}$ promoter. The promoterless xylA gene containing the ribosome binding site and coding region for D-xylose isomerase was cloned into a ...
The development of lymphoid organs depends on cross talk between hematopoietic cells and mesenchymal stromal cells and on vascularization of the lymphoid primordia. These processes are orchestrated by cytokines, chemokines, and angiogenic factors that require tight spatiotemporal regulation. Heparan sulfate (HS) proteoglycans are molecules designed to specifically bind and regulate the bioactivity of soluble protein ligands. Their binding capacity and specificity are controlled by modification of the HS side chain by HS-modifying enzymes. Although HS proteoglycans have been implicated in the morphogenesis of several organ systems, their role in controlling lymphoid organ development has thus far remained unexplored. In this study, we report that modification of HS by the HS-modifying enzyme glucuronyl C5-epimerase (Glce), which controls HS chain flexibility, is required for proper lymphoid organ development. Glce(-/-) mice show a strongly reduced size of the fetal spleen as well as a spectrum of ...
Complete information for GNE gene (Protein Coding), Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Xylose dehydrogenase plus Xylose mutarotase Enzyme for use in research, biochemical enzyme assays and in vitro diagnostic analysis. Purchase Xylogl...
Exhibits fucose binding activity and racemase and epimerase activity, acting on carbohydrates and derivatives. Involved in several processes, including female mating behavior; fucose metabolic process; and negative regulation of neuron differentiation. Orthologous to human FUOM (fucose mutarotase ...
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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Shop L-ribulose-5-phosphate 4-epimerase ELISA Kit, Recombinant Protein and L-ribulose-5-phosphate 4-epimerase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
D-xylose isomerase (XI) is capable of sugar isomerization and slow conversion of some monosaccharides into their C2-epimers. We present X-ray and neutron ...
GALE antibody [N2C3] (UDP-galactose-4-epimerase) for WB. Anti-GALE pAb (GTX114419) is tested in Human samples. 100% Ab-Assurance.
The Takahashi SE series tripods are designed specially for the serious astrophotographer and are compatible with the Takahashi EM-11 and EM-200 mounts.
Regretfully,I have to sell my Takahashi TOA-150 6* triplet refractor. Im including a Takahashi 1.6X 2" Extender for TOA,a Takahashi 4" Field Flattener for...
MetabolismCentral intermediary metabolismAmino sugarsglucosamine-6-phosphate deaminase (TIGR00502; EC 3.5.99.6; HMM-score: 33.2) ...
Dr. Naoto Takahashi is currently affiliated to Third Department of Internal Medicine, Akita University School of Medicine, Japan, continuing research in the specialize..
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Alginate is a family of industrially important polysaccharides composed of irregular sequences of 1-4 linked β-D-mannuronic acid (M) and α-L-guluronic acid (G). They are widely used industrially as iscosifiers and gelling agents. Medical applications include utilization as dental impression materials, wound dressings and as an encapsulation matrix for cell transplants in the treatment of various diseases. Some alginates are immunogenic or have anti-tumor activity.. Commercial alginates are extracted from brown seaweeds, but the polymer is also produced by members of the bacterial genera Pseudomonas and Azotobacter. Probably in all species the alginate is first synthesized as polymannuronic acid, and then the guluronic acid moieties are introduced at the postpolymerization level by the action of mannuronan C-5- epimerases. Azotobacter vinelandii encodes a family of 7 secreted, Ca2+ -dependent mannuronan C-5-epimerases, AlgE1-7, which are composed of varying numbers of two types of structural ...
GNE myopathy, previously known as Hereditary Inclusion Body Myopathy (HIBM), or Nonaka Myopathy, is an autosomal recessive myopathy with onset in early adulthood characterized by progressive muscle atrophy and weakness. The causative gene, GNE, encodes for the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) that catalyzes the rate-limiting step in the biosynthesis of sialic acid (Neu5Ac). The subsequent impairment of Neu5Ac production is presumed to cause decreased sialylation of GNE myopathy muscle glycoproteins, resulting in muscle deterioration. In this protocol, we will clinically evaluate patients with GNE myopathy. To date, the amount of prospectively collected and published natural history data on GNE myopathy has been minimal due to the rare nature of this disease. This natural history study seeks to further characterize the phenotype, progression and complications of the disease. Additionally, the study is designed to identify endpoints and ...
GNE myopathy, also known as Hereditary Inclusion Body Myopathy (HIBM) is an autosomal recessive myopathy with onset in early adulthood characterized by progressive muscle weakness. The causative gene, GNE, codes for the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) that catalyzes the first two steps in the biosynthesis of sialic acid (SA). The subsequent paucity of SA production is presumed to cause decreased sialylation of GNE myopathy muscle glycoproteins, resulting in muscle deterioration. To date, the amount of prospectively collected and published natural history data on GNE myopathy has been minimal due to the rare nature of this disease. This natural history study seeks to further characterize the rate of progression of the disease and how it relates to age of onset. Additionally, the study is designed to elucidate functional outcome measures (endpoints) for future therapeutic trials, and correlate serum biomarkers and muscle magnetic resonance ...
In enzymology, a xylose isomerase (EC 5.3.1.5) is an enzyme that catalyzes the interconversion of D-xylose and D-xylulose. This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The isomerase has now been observed in nearly a hundred species of bacteria. Xylose-isomerases are also commonly called fructose-isomerases due to their ability to interconvert glucose and fructose. The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. The activity of D-xylose isomerase was first observed by Mitsuhashi and Lampen in 1953 in the bacterium Lactobacillus pentosus. Artificial production through transformed E.coli have also been successful. In 1957, the D-xylose isomerase activity on D-glucose conversion to D-fructose was noted by Kooi and Marshall. It is now known that isomerases have broad ...
Component of a complex that catalyzes the oxidation of glycolate to glyoxylate (PubMed:4557653, PubMed:8606183). Is required for E.coli to grow on glycolate as a sole source of carbon (PubMed:8606183). Is also able to oxidize D-lactate ((R)-lactate) with a similar rate (PubMed:4557653). Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown (PubMed:4557653).
Heparan sulfate (HS) and heparin are linear polysaccharide chains covalently O-linked to serine residues within the core proteins, so called HS proteoglycans (PGs) or heparin PG. HSPGs are produced by almost all mammalian cells and known to play important roles in developmental processes, physiological and pathological conditions; whereas heparin PG is produced by mast cells and best known as an anticoagulant in clinic.Biosynthesis of HS/heparin occurs in Golgi compartment and involves many enzymes, one of which is glucuronyl C5-epimerase (Hsepi) that catalyzes the conversion of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA). Heparanase is an enzyme involved in metabolism of HS; it cleaves the linkage between GlcA and glucosamine residues in HS/heparin chains. Heparanase is expressed essentially by all cells and found up-regulated in many metastatic tumors.This thesis focuses on the structure and functions of HS/heparin through studies on the implications of Hsepi and heparanase. My study ...
We have generated two transgenic mice strains (one is overexpressing the mutated key enzyme of the sialic acid biosynthesis, which leads to high sialic acid levels and one has a defect in the sialic acid biosynthesis). Both strains will be compared with wild-type animals. We plan to analyse O-GlcNAc, sialic acid, sialic acid binding proteins and sialic acid-dependent differentiation markers in all organs over the whole lifespan and quantify age-dependent muscle performance in vivo. The outcome of metabolic sialic acid engineering will be analysed in embryonic stem cells (differentiation) and neuronal cells (neurite outgrowth e.g. regeneration). We also plan to analyse the involvement of sialylation and O-GlcNAcylation on the function of endothelial cells. After metabolic engineering we will analyse their barrier capacity and age-related impact on neuronal cells by real-time cell analysis. Since high levels of glucose induce glycation of proteins, we will analyse the function of an artificial ...
We have generated two transgenic mice strains (one is overexpressing the mutated key enzyme of the sialic acid biosynthesis, which leads to high sialic acid levels and one has a defect in the sialic acid biosynthesis). Both strains will be compared with wild-type animals. We plan to analyse O-GlcNAc, sialic acid, sialic acid binding proteins and sialic acid-dependent differentiation markers in all organs over the whole lifespan and quantify age-dependent muscle performance in vivo. The outcome of metabolic sialic acid engineering will be analysed in embryonic stem cells (differentiation) and neuronal cells (neurite outgrowth e.g. regeneration). We also plan to analyse the involvement of sialylation and O-GlcNAcylation on the function of endothelial cells. After metabolic engineering we will analyse their barrier capacity and age-related impact on neuronal cells by real-time cell analysis. Since high levels of glucose induce glycation of proteins, we will analyse the function of an artificial ...
1FSF: Structural flexibility, an essential component of the allosteric activation in Escherichia coli glucosamine-6-phosphate deaminase.
Triosephosphate isomerase antibody, C-term (triosephosphate isomerase 1) for IHC-P, WB. Anti-Triosephosphate isomerase pAb (GTX89594) is tested in Human, Mouse samples. 100% Ab-Assurance.
Find quality suppliers and manufacturers of 551-68-8(D-Psicose) for price inquiry. where to buy 551-68-8(D-Psicose).Also offer free database of 551-68-8(D-Psicose) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
고정화효소와 산소전극 시스템을 이용한 효소센서를 제작하여 식품 중의 당, 유기산, 알코올 성분을 동시 측정 하였다. 효소가 기질과 반응하여 소비한 산소의 변화량이 전압차이로 나타나므로 시간당 전압 감소량이 최대인 값으로부터 각 성분의 농도를 측정하였으며, 이때 1분내에 최대기울기를 구할 수 있어 신속한 측정이 가능하였다. 효소의 고정화 지지체로는 nylon cloth를 사용하였고, asymmetrical coupling 방법에 의하여 기질 작용 순으로 위치하도록 효소를 고정화하였다. 한 개의 양극과 6개의 음극으로 제작된 multiple cathode system으로 포도당, 젖산, 에탄올 성분을 동시 측정할 수 있는 효소 센서를 제작하였다. 위의 센서 제작을 위하여 mutarotase과 glucose oxidase/lactate oxidase/alcohol oxidase와 catalase가 각기 사용되었다. 이들 효소센서의 최적조건은 |TEX|$pH\;7.0,\;40^{\circ}C$|
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Striving to create factories measuring several dozen mm wide and several mm deep. When we can see things which we have never been able to see before, and create things we have never been able to create before, cell-in-micro-factories will integrate these optical manufacturing technologies. These factories, smaller by far than anything that has come before, are Professor Takahashis own original idea. The smallest factories which exist today are desktop micro-factories, which consist of machine tools such as micro-lathes. Cell-in-micro-factories, measuring just several dozen millimeters wide by several millimeters deep, are to contain the most advanced optical technologies, performing everything from measurement, processing, and handling to conveyance and defect detection. The objects they manufacture will measure less than 1 millimeter. When asked where his creativity springs from, Professor Takahashi answers, I come from Kansai, so I love comedy. Comedy consists of gaps, right? I think ...
Harvard was the first institution of higher education in the United States to address worker equity issues when the University instituted its Wage and Benefit Parity Policy (WBPP) in 2002.
Partially-Shared Variational Auto-encoders for Unsupervised Domain Adaptation with Target Shift Ryuhei Takahashi Kyoto University [email protected] Masaaki Iiyama Kyoto University [email protected]
Affiliation:医科歯科大,助教授, Research Field:Surgical dentistry,外科・放射線系歯学, Keywords:口腔癌,LAK細胞,養子免疫療法,HLA,CD80,DQB1,LAK,DPB1,DRB1,インターロイキン2, # of Research Projects:15, # of Research Products:0
Toyao, T., Liang, K., Okada, K., Ricco, R., Styles, M. J., Tokudome, Y., Horiuchi, Y., Hill, A. J., Takahashi, M., Matsuoka, M. & Falcaro, P., 1 Mai 2015, in : Inorganic chemistry frontiers. 2, 5, S. 434-441 8 S.. Publikation: Beitrag in einer Fachzeitschrift › Artikel ...
Studied to be used in hospitals and physiotherapy clinics, Medisound 3000 has technical and software-management features developed to meet the needs of any medical rehabilitation center ...