Since ventricular fibrillation is the predominate cause of death following experimental coronary occlusion, measurement of the ventricular fibrillation threshold is recommended to assess the value of cardiac revascularization procedures. This determination is quantitative, precise and permits measurement under controlled circumstances. It was dissatisfaction with measurement of mortality rate following coronary occlusion in control and experimental animals (bioassay technic) that led to the adoption of the present more exact method.. Acute ligation of the anterior descending branch of the left coronary artery causes an immediate drop in the fibrillation threshold to one-fifth of normal. This is not changed if one releases the artery and retests the animal with occlusion 5 to 6 months later. Implantation of the internal mammary artery into the myocardium of the left ventricle creates a greater resistance to ventricular fibrillation after coronary occlusion. In animals in which the internal ...

The ventricular fibrillation threshold (VFT) was measured in 28 patients at the time of cardiac surgery. The VFT was measured with a 100 Hz train of 24 rectangular pulses positioned across the ST segment and T wave. Current was applied to the epicardial surface of either ventricle with a bipolar electrode probe. In six patients, the normal right VFT was 24.3 +/- 5.2 mA, and in 10 patients the normal left VFT was 33.6 +/- mA (p less than 0.05). In 12 patients with greater than or equal to 75% obstruction of the left anterior descending coronary artery, the left VFT was 18.6 +/- 6.9 mA. This value was significantly less than the left VFT in patients without coronary artery disease (p less than 0.001). This study shows that the VFT can be measured in man and that coronary artery disease reduces this parameter. ...

TY - JOUR. T1 - Effect of ligands of opiate receptors on morphofunctional state of the sympathoadrenal system and electrical stability of the heart in acute cold exposure. AU - Lishmanov, Yu B.. AU - Kondratev, B. Yu. AU - Maslov, L. N.. AU - Naryzhnaya, N. V.. PY - 1997/2. Y1 - 1997/2. N2 - Acute cold exposure (-20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity of the myocardium, prevents the decrease in the ventricular fibrillation threshold induced by acute cold exposure.. AB - Acute cold exposure (-20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity of the myocardium, prevents the decrease in the ventricular fibrillation ...

This page was last edited 01:50, 25 July 2014 by wikidoc user GeraldChi. Based on work by Cafer Zorkun and Alexandra Almonacid, wikidoc user WikiBot and wikidoc anonymous user Fvasconcellos ...

Background Hair shaft diameter is one of the most important factors for the outcome of follicular unit extraction (FUE) surgery. In fact, the hair shaft is elliptical. Therefore, it has a long and short axis. Many hair transplantation surgeons use manual micrometer caliper for gauging hair diameter and use the results in the management of recipient and donor area. ...

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In this multicenter cohort, only ≈40% of patients referred for RDN, mostly by specialists, were eligible for the procedure, according to the SYMPLICITY HTN-2 criteria, as well as according to the centers own judgment. These data confirm at the European level the results obtained by Verloop et al18 in a Dutch single-center cohort, also included in ENCOReD. The proportion of less complex, standard patients with resistant hypertension in whom RDN seems both feasible and justified is probably still an order of magnitude lower (7.5% in patients with resistant hypertension hospitalized for hypertension in a French third referral center; 2.6% according to a recent US chart review)2,19 and might further decrease if all patients would be assessed for drug adherence20 or would have received maximal and optimized drug treatment, including low-dose spironolactone whenever possible.19. As in the Dutch study,18 patients found to be ineligible for RDN in our current study were older and had lower office and ...

In applications where the bearing size is determined by factors other than load - for example, shaft diameter constrained by critical speed - the bearing may be lightly loaded in relation to its size and carrying capacity. Where there are very light loads, failure mechanisms other than fatigue, such as skidding and smearing of raceways or cage damage, often prevail. To provide satisfactory operation, rolling bearings must always be subjected to a given minimum load. As a general rule, minimum loads of 0,01 C should be imposed on ball bearings and 0,02 C on roller bearings. More accurate minimum load requirements are given in the product sections ...

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Sure bunk beds will solve the spacing issue while providing each child with their own bed; however, regular bunk beds are not always the best answer. The reality is that our children do more in their rooms than sleep and play with their toys. Their rooms also have to serve as the homework center, the entertainment area and more. For situations like this youre best option is to acquire a futon bunk bed set. Futon bunk beds function in the same manner as a regular bunk beds; the only difference is that it has additional uses. For instance take a look at the picture to the left ...

Reference-free method for conducting EWAS while deconvoluting DNA methylation arising as mixtures of cell types. The older method (Houseman et al., 2014,,doi:10.1093/bioinformatics/btu029,) is similar to surrogate variable analysis (SVA and ISVA), except that it makes additional use of a biological mixture assumption. The newer method (Houseman et al., 2016, ,doi:10.1186/s12859-016-1140-4,) is similar to non-negative matrix factorization, with additional constraints and additional utilities.. ...

100% Natural Shea Butter! Shea Butter will provide improvement in all the conditions listed below. As you use this multi-purpose butter, you are likely to discover additional uses. The amount of time required for optimum results with various conditions may vary with each condition. Wrinkles, for example, require 4 to 6 weeks of daily use. Itching is relieved immediately.

A new surgical technique may (ELAR) is again performed through a small incision around the navel and using an HD camera, the muscles at the proper place, closed the hernia and abdominal wall stability are restored. With additional use of a classic plastic network or a completely resolution (absorbable) network this reconstruction will be held on time and the biomechanics of the abdominal and back muscles is again in the balance, so that often belong also passed back pain the past and Sport is again possible. About Stretched sagging skin, for example, just after pregnancy tightens after such an operation by itself, and plastic surgery (tummy tuck etc.) are usually unnecessary.. The operation is scheduled for individual examination incl. Ultrasound and then conducted by us at a partner hospital under Vollnachkose. After about 4-5 days a dismissal in the outpatient care is available and for 6 weeks a waist belt worn and lifting loads than 5 kg should be avoided. Then there are no more restrictions ...

There are approximately 20,000 new cases of rheumatoid arthritis in the UK every year [8]. These data show that most people who acquire RA do so when they are of working age and are productive, contributing members of society. It is obvious from the above that the incidence of RA amongst productive members of society in the European Union is causing significant distress, economic costs, and loss of productivity which affects Europeans quality of life in addition to placing additional burden on health care systems and health budgets across the EU. Therefore the economic impact of early intervention will be significant. Recent studies have indicated that early intervention can significantly reduce the clinical impact of the condition. Treatment choices for RA patients include corticosteroids and disease modifying anti-rheumatic drugs (DMARDs), such as methotrexate. For patients who fail to respond to these conventional therapies, the additional use of biologic TNF inhibitors offers greater ...

The following are known as direct tests because they detect the organism itself, rather than detecting compounds generated by the disease, such as antibodies, inflammatory cytokines and other compounds which form part of the immune response.. Culture: the multiplication of bacteria, taken from infected tissue or body fluids, on artificial media in a laboratory. Multiplication aids identification. Borrelia are extremely small and cannot readily be distinguished from some other spirochaetes (spiral shaped bacteria of the same family) without the additional use of PCR (see below).. Microscopy: the use of a microscope to identify bacteria. The same comment on identification of Borrelia applies.. PCR: Polymerase Chain Reaction. A method of amplifying a targeted region of DNA. This can be used to identify the presence of specific gene sequences of a target such as Borrelia burgdorferi. This can be down to genospecies level.. DMARD ...

Immune defenses depend on the ability of immunoreceptors to recognize foreign antigens and initiate intracellular signaling when a pathogen is detected. Signal initiation requires spatial reorganization of proteins and site-specific receptor phosphorylation, which leads to engagement of feedback loops. This Journal Club discusses recent work using combined experimental and computational approaches to investigate these processes in B cell antigen receptor (BCR) signaling. Specifically, the roles of different kinases in the presence and absence of BCR clustering were evaluated. Results indicated that spleen tyrosine kinase (SYK) can compensate for loss of Src-family kinase activity when receptors are spatially clustered, in part because receptor clustering enables SYK to trigger a positive feedback loop. This study and its implications suggest additional uses for computational models in studies of immunoreceptor signaling and highlight areas where extensions of current methodology are needed to ...

The ipsogen JAK2 RGQ PCR Kit received clearance from the U.S. FDA for additional use in the diagnosis of all myeloproliferative neoplasms.

h o r t-R a n g e O r d e r D e ta ils o f M e ta p h o s p h a te G la s s e s S tu d ie d b y P u ls e d N e u tr o n S c a tte r in g Details of the short-range order of the binary metaphosphate glasses A1P30 9 and PbP2Oe and the ternary glass system ZnO-MgO-2P2Os have been studied by pulsed neutron scattering which provides a measuring range up to about ß m ax = 500 nm-1. The splitting of the P-O peak in the distance correlation functions attributable to the different bond lengths for the non-bridging and bridging oxygens was found to decrease with increasing field strength of the network-modifier cations. For the ternary system ZnO-MgO-2P2Os the peak in the distance correlation function, T(r), produced by the first oxygen neighbours around Zn2+ and Mg2+ was separated by the additional use of the X-ray structure factor. The distances rZn0 and rM gQ extracted from the separated peaks are slightly different from those obtained from the binary glasses ZnP20 6 and MgP20 6. The metal-oxygen ...

All images are owned by Matt Reese Photography and protected under the Copyright Act of 1976. LICENSING​ ​&​ ​RIGHTS​:​ ​Grant​ ​of​ ​any​ ​reproduction​ ​rights​ ​is​ ​conditioned​ ​upon​ ​receipt​ ​of​ ​payment​ ​in​ ​full.​ ​All​ ​rights​ ​not​ ​expressly​ ​granted remain​ ​the​ ​exclusive​ ​property​ ​of​ ​Matt​ ​Reese​ ​Photography​ ​LLC​ ​(Licensor).​ ​Any​ ​additional​ ​uses​ ​require​ ​the​ ​prior​ ​written​ ​agreement​ ​of​ ​Licensor on​ ​terms​ ​to​ ​be​ ​negotiated.​ ​Unless​ ​otherwise​ ​stated​,​ ​duration​ ​of​ ​the​ ​grant​ ​of​ ​rights​ ​is​ ​one ​(1)​ ​year​ ​from​ ​invoice​ ​date and​ ​limited​ ​to​ ​use​ ​in​ ​the​ ​United​ ​States​ ​of​ ​America.​ ​NO​ ​THIRD​ ​PARTY​ ​USE​ ​IS​

The mechanism underlying hypercalcaemia in TB is thought to be over-production of 1,25(OH)2D3 in extra-renal macrophages in granulomas, for example in the alveoli. It has been suggested that the production of 1,25(OH)2D3 has a protective effect against oxidative injuries from the nitric oxide burst from granulomatous macrophages [11]. This was initially studied in other granulomatous diseases, such as sarcoidosis. In TB, 1,25(OH)2D3 has been shown to be produced by alveolar macrophages from a patient with pulmonary TB [12], and high serum levels have been found in anephric patients, further supporting an extra-renal source [13]. Because production is extra-renal, the normal feedback control of 1,25(OH)2D3 production by parathyroid hormone is ineffective.. However, TB-associated hypercalcaemia has also been reported in patients with normal [4] and low [14] levels of serum 1,25(OH)2D3. Other causes may include an overdose of vitamin D or calcium supplements. An alternative possibility is abnormal ...

The analysis of triacylglycerol (TG) species is of interest in diseases that are associated with hypertriglycidemia. The individual composition of TGs seems to be of special interest in the...

The question whether the sequential diuretic therapy, that means using an antialdosteronic drug at first and adding a loop diuretic in nonresponders, is better than the combination of the two diuretics from the beginning (combined diuretic therapy) in the treatment of ascites in patients with cirrhosis is still open. Therefore, the aim of the study is to compare sequential versus combined diuretic therapy in these patients. One hundred patients will be randomized into two groups. Group A will receive potassium canrenoate at the initial dose of 200 mg/day, then increased up to 400 mg/day. Non responders will be treated with 400 mg/day of potassium canrenoate and furosemide at an initial dose of 50 mg/day, then increased up to 150 mg/day. Group B will receive at first 200 mg/day of potassium canrenoate and 50 mg/day of furosemide, then increased up to 400 mg/day and 150 mg/day, respectively.. The percentage of responders to dthe diuretic treatment, the time to get the resolution of ascites and the ...

Aldosterone Antagonist Pipeline Insight, 2020 report by DelveInsight offers comprehensive insights of the pipeline (under development) therapeutics scenario and growth prospects across Aldosterone Antagonist development.

Sigma-Aldrich offers abstracts and full-text articles by [Yasir H Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal, Mohammad Faisal].

All structured data from the main, Property, Lexeme, and EntitySchema namespaces is available under the Creative Commons CC0 License; text in the other namespaces is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...

Brooker and colleagues described their experience with an exciting new variable stiffness colonoscope. They made the point that a stiffer colonoscope shaft reduces recurrent looping but makes passage through an angulated sigmoid more difficult and causes more stretching and hence pain when loops do occur. Conversely, the more flexible thinner paediatric instruments are better for negotiating a fixed or narrow sigmoid colon but then tend to allow recurrent loop formation later in the procedure. Their randomised trial using either a standard Olympus CF200HL (13.3 mm shaft diameter) or a prototype (Olympus XCF-SH230L-12.9 mm shaft diameter) variable stiffness colonoscope looked very promising although in one case a paediatric Olympus PCF230I (11.3 mm shaft diameter) was required to get past a fixed sigmoid secondary to diverticular disease.. In addition to Brooker et al, there are a number of research workers1-4 and endoscope manufacturers interested in colonoscope/flexible sigmoidoscope shaft ...

BACKGROUND: Treatment with angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) is increasingly used to reduce proteinuria and retard the progression of chronic kidney disease (CKD). However, resolution of proteinuria may be incomplete with these therapies and the addition of an aldosterone antagonist may be added to further prevent progression of CKD. This is an update of a review first published in 2009.. OBJECTIVES: To evaluate the effect of aldosterone antagonists (both selective (eplerenone) and non-selective (spironolactone)) alone or in combination with ACEi or ARB in adults who have CKD with proteinuria (nephrotic and non-nephrotic range) on: patient-centred endpoints including major cardiovascular events, hospitalisation and all-cause mortality; kidney function (proteinuria, glomerular filtration rate (GFR), serum creatinine, and need for renal replacement therapy; and adverse events (including gynaecomastia and hyperkalaemia).. SEARCH METHODS: For ...

This randomized trial showed that the addition of spironolactone in patients with resistant arterial hypertension using a mean of 4.5 antihypertensive drugs, led to a significant decrease of systolic BP both in the office and on ABPM after 8 weeks of treatment. Spironolactone, compared to the placebo, did not significantly influence the diastolic BP, although a trend toward a decrease was observed for the ABPM nighttime and office diastolic BP. Spironolactone led to small but significant increases of serum potassium and creatinine without adverse clinical consequences and was well tolerated, and the number of side effects was comparable to the placebo.. To our knowledge, this is the first randomized trial to assess the antihypertensive effects of low-dose spironolactone in patients with truly drug-resistant hypertension. Previous uncontrolled observational trials showed a substantial BP reduction after the addition of spironolactone (ranging from 21.7 to 25 mm Hg systolic and 8.5 to 12.5 mm Hg ...

Increased blood volume and red blood cell mass Increased skeletal muscle capillary density, mitochondrial mass, and oxidative capacity Increased left ventricular mass, end-diastolic dimension, and stroke volume Increased diameter of coronary arteries Decrease in resting heart rate Likely increase in ventricular fibrillation threshold Explain the different cardiovascular responses to volume overload and pressure overload. Exercise […] Read more. ...

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Spironolactone is a steroid chemically similar to aldosterone. Aldactone increases calcium excretion by direct action on renal tubules. Spironolactone reduces blood pressure slightly. Spironolactone is used in conjunction with other diuretics to prevent potassium loss and to augment antihypertensive action. Spironolactone is more useful in cirrhotic and nephrotic edema. You can buy Spironolactone here at Rx 2 Go Pharmacy and get the guarantee of the cheapest prices all through the year.

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​The life of a seawater pump is limited, even if maintenance activities such as replacement of sealing and impeller are performed regularly. The reason for this is corrosion, which is caused by the constant condensation of the pump even if the engine is at a standstill, as well as material removal due to erosions as a result of the high flow speed of the seawater inside the pump housing. Often small but steadily increasing leakages, usually at the bottom of the housing, are signs of a seawater pump's demise. At that point, you should think about a replacement. In order to assist skilled skippers in carrying out their own repairs without causing a total financial loss, we have now offered seawater pumps for the most common types of engines on the market since 2015. Dimensions, connection widths, flow rates and shaft diameters can be found in the table. There you will also find information on which pump is suitable for which manufacturer/motor type. We have seawater pumps (impeller pumps) from the

Serious skin problems. These are problems that can make it hard for a person to function day to day. Simple over the counter treatments might not be enough to offer help. In many cases an appointment to the doctor is going to be needed in order to find out exactly whats going on.. Bactroban is a medicational treatment thats designed to help people who suffer from moderate to severe skin problems. Its generic name is Mupirocin. Its an effective antibiotic thats able to stop bacteria from growing on a persons skin. It can also be used in order to treat different skin infections like impetigo or Staph infections of the skin. There are additional uses for this treatment, but this will be left to the discretion of a doctor.. Whats some important information you need to make sure you understand before you were to start using this medicational treatment?. Make sure you use this treatment for the complete period of time a doctor tells you to or as youre told to on the packaging. This is even if ...

The originals of images offered in this catalog were contributed to the Mammal Images Library with the understanding that the Mammal Images Library will sell copies only for optical projection for nonprofit instruction. However, some contributors will allow their slides to be used for other purposes; this permission is set forth in a written Contribution Agreement between the contributors and the Mammal Images Library. These additional permissible uses, and arrangements for royalties derived from additional uses, vary among the contributors. Persons or organizations wishing to use images for purposes other than projection for nonprofit instruction or copying the slide in any way must first contact the Chair of the Mammal Images Library to get information about the use of specific images. Failure to obtain the required permission jeopardizes the ability of the Mammal Images Library to operate its program. This program depends on the good will of contributors, the voluntary efforts by the MIL ...

Branch Whitneys Hiking Las Vegas: Protect Your Ropes with Chafe Pro. Chafe-Pro®s chafe guards have been designed specifically for the recreational boater who use smaller diameter lines (ropes). However, I have found an additional use for them: to protect hand lines (ropes) that have been permanently placed in the mountains to assist hikers/climbers up difficult sections of rock.. What happens is the rope becomes abraded as it rubs across the rock. Over time this can compromise the rope and it can become dangerous. Normally we replace the ropes when needed. By covering the rope with Chafe-Pro®s chafe guards the rope will not become abraded thus keeping hikers and climbers safe.. The chafe guards I have are 26 inches in length. They are closed along the length (all 26 inches) and on each end by heavy-duty velcro. They are very thick and should protect the rope for years. Chafe guards are very flexible and can bend around the rock ...

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Power Factor Correction is the use of technology to restore power factor as close to unity as possible. This is usually achieved by the additional use of capacitors to the electrical network. Although capacitor banks help with power factor correction, they definitely leave room for improvement. Enerdoor understood this and developed a new technology, the FINSVG, which provides a better solution for power factor correction than the commonly used capacitor banks.. Power Factor, or the ratio of real power to apparent power, has an ideal measurement of 1. Manufacturing plants generally experience low power factor. Electrical utility companies often charge these manufacturing plants penalties and additional fees when the power factor correction is 90% or less. Additionaly, as an incentive for facilities to improve power factor, electrical utility companies offer a credit on electricity bills when the power factor is greater than 95%. Low power factor not only create additional costs, it also causes ...

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This study will investigate the effects of anti-digoxin polyclonal antibody [DIGIBIND] on marinobufagenin levels in pregnant women with preeclampsia.

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I just found out yesterday I was pregnant, went to the doctor and he estimated me at about six weeks... Since november I have been taking 100mg once a day of spironolactone used as off label acne medicine... Been reading it may be dangerous... does anyone know or has anyone gone thru this and everything is fine? I am on vacation... cant wait to go home to MY doctor lol thanks ladies