Caliciviral infections in humans, among the most common causes of viral-induced vomiting and diarrhea, are caused by the Norwalk group of small round structured viruses, the Sapporo caliciviruses, and the hepatitis E agent. Human caliciviruses have been resistant to in vitro cultivation, and direct study of their origins and reservoirs outside infected humans or water and foods (such as shellfish contaminated with human sewage) has been difficult. Modes of transmission, other than direct fecal-oral routes, are not well understood. In contrast, animal viruses found in ocean reservoirs, which make up a second calicivirus group, can be cultivated in vitro. These viruses can emerge and infect terrestrial hosts, including humans. This article reviews the history of animal caliciviruses, their eventual recognition as zoonotic agents, and their potential usefulness as a predictive model for noncultivatable human and other animal caliciviruses (e.g., those seen in association with rabbit hemorrhagic disease).
TY - JOUR. T1 - Caliciviruses. T2 - A major cause of foodborne illness. AU - Gerba, C. P.. AU - Kayed, D.. PY - 2003/5. Y1 - 2003/5. N2 - The public health impact of infections by human caliciviruses (HuCVs) is increasingly being recognized. The Norwalk-like viruses (NLV) are the most common cause of outbreaks of nonbacterial gastroenteritis and the most recognized foodborne viral etiologic agents. Factors that contribute to their high burden of infection are low infectious dose, stability in the environment, the diversity of strains, and the lack of long-term immunity to infection or illness. The recent development of sensitive molecular techniques for diagnosis, quantification, and characterization of these agents has led to the recognition of the importance of NLV infection. Future applications of these approaches to understanding modes of transmission and the effectiveness of control measures holds promise for improved understanding of the epidemiology of HuCVs, as well as important control ...
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Publications in 2015 The underlined (otherwise all) authors are from the Institute Papers Alkan F, Karayela I, Catella C, Bodnar L, Lanave G, Bányai K, Di Martino B, Decaro N, Buonavoglia C, Martella V. (2015): Identification of a bovine enteric calicivirus, Kırklareli virus, distantly related to neboviruses, in calves with enteritis in Turkey. Journal of Clinical. Microbiology, 53(11): 3614-3617.
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The Garry Lab is pleased to announce the addition of a new resource to our collection of links, All the Virology on the WWW: http://www.tulane.edu/~dmsander/garryfavweb.html Amoung other updates, and at the request of our many supporters, we have created a site that focuses on virology and science jobs. It can be found at: http://www.tulane.edu/~dmsander/garryfavwebjobs.html At this site you will find links specific to government, academic, consulting and corporate jobs. Additionally we list a variety of resources including: professional societies, general job databases, positions advertized in journals / magazines, Recruiting agencies and Job Banks, meta-lists of other jobs sites, Usenet News, and other helpful resources. If you have any sites that you would like to add to our list of Job pages on the WWW, please use the submission form at: http://www.tulane.edu/~dmsander/garryfavwebadd.html Thanks again for your support, and Happy Marti Gras! David ...
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Caliciviridae is a family of viruses, members of Class IV of the Baltimore scheme. They are positive-sense, single stranded RNA which is non-segmented. There are currently seven species in this family, divided among 5 genera. Diseases associated with this family include: feline calicivirus: respiratory disease; rabbit hemorrhagic disease virus: often-fatal hemorrhages; norwalk group of viruses: gastroenteritis. Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/spherical and has icosahedral symmetry (T=1 or T=3) with a diameter of 35-39 nm. Caliciviruses are not very well studied because until recently they could not be grown in culture, and there is no suitable animal model. However, the recent application of modern genomic technologies has led to an increased understanding of the ...
Its efficacy in presence of maternally derived FCV antibodies. References. 1. Baulch-Brown, C., Love, D.N., Meanger, J., 1997. Feline calicivirus: a need for vaccine modification ? Aust. Vet. J. 75(3), 209-213.. 2. Baulch-Brown, C., Love, D.N., Meanger, J., 1999. Sequence variation within the capsid protein of Australian isolates of feline calicivirus. Vet. Microbiol. 68, 107-117.. 3. Binns, S.H., Dawson, S., Speakman, A.J., Cuevas, L.E., Hart, C.A., Gaskell, C.J., Morgan, K.L., Gaskell, R.M., 2000. A study of feline upper respiratory tract disease with reference to prevalence and risk factors for infection with feline calicivirus and feline herpesvirus. Journal of Feline Medicine and Surgery 2, 123-133.. 4. Chappuis, G., Stellmann, C., 1974. Etude sérologique des picornavirus félins: parenté-dominance des souches. Bull.Soc.Sci.Vet et Med comparée, 76(4), 289-299.. 5. Dawson, S., McArdle, F., Bennett, D., Carter, M., Bennett, M., Ryvar, R., Gaskell, R.M., 1993. Investigation of vaccine ...
Feline Calicivirus Vaccine shall be prepared from virus-bearing cell culture fluids. Only Master Seed Virus which has been established as pure, safe, and immunogenic shall be used for preparing the production seed virus for vaccine production. All serials of vaccine shall be prepared from the first through the fifth passage from the Master Seed Virus. (a) The Master Seed Virus shall meet the applicable general requirements prescribed in § 113.300. (b) The Master Seed Virus shall be tested for chlamydial agents as prescribed in § 113.43. (c) Each lot of Master Seed Virus used for vaccine production shall be tested for immunogenicity. The selected virus dose from the lot of Master Seed Virus shall be established as follows: (1) Thirty feline calicivirus susceptible cats shall be used as test animals (20 vaccinates and 10 controls). Throat swabs shall be collected from each cat and individually tested on susceptible cell cultures for the presence of feline calicivirus. Blood samples shall be ...
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Antigen Background The Caliciviridae are a family of positive-stranded RNA viruses of unique morphology characterized by a series of cup-like depressions on the surface of the virus. Feline Calicivirus (FCV) is a ubiquitous pathogen of cats producing a variety of clinical symptoms, including oral ulceration, upper respiratory tract infection and polyarthritis. FCV has a genome of 7.7kb which encodes several proteins. Product Specific Information NCL-1G9 detects one of these, a capsid protein of 62 kD.. ...
The kinetics and biochemical properties of feline calicivirus (FCV) attachment to Crandell-Reese feline kidney cells were determined. Maximum binding was observed at pH 6.5. Cells in suspension at...
Summary Isolates of feline calicivirus (FCV) can be divided into four groups according to plaque size under an agar overlay. All isolates classified as minute plaque, along with certain other isolates, are sensitive to inhibitors present in agar.
Science & Technology, Life Sciences & Biomedicine, Cell Biology, Medicine, Research & Experimental, Multidisciplinary Sciences, Research & Experimental Medicine, Science & Technology - Other Topics, feline calicivirus, caspase activation, capsid protein, DEATH ...
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With plexiglass barriers, de-densified classrooms, staggered schedules and courses taught simultaneously online and in person, Tulane is implementing public health measures and employing the latest technology to promote the safety of our academic community and to mitigate risks associated with COVID-19. Coursework at Tulane is innovative, collaborative and transformative. We are committed to retaining these qualities, while requiring students to mask, socially distance and encouraging good hand hygiene practices upon entering and leaving classrooms.. This summer, all classrooms underwent cleaning and disinfection by professional contract cleaners. Campus Services, in consultation with an external certified industrial hygienist, epidemiologists and Tulanes Office of Environmental Health and Safety, has developed detailed protocols for continued cleaning and disinfection in accordance with CDC and OSHA guidance. Sanitizing wipes will be provided so faculty and students can wipe down workspaces ...
Tulane Universitys Stryder Meadows, a cell and molecular biology professor, received a $1.7 million grant from the Department of Defense to study how arteriovenous malformations (AVM), which are d
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Al-Molawi, N, Beardmore, VA, Carter, MJ, Kass, GEN and Roberts, LO (2003) Caspase-mediated cleavage of the feline calicivirus capsid protein ...
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Affiliations: Tulane Cancer Center Tulane Vector Borne Infectious Diseases Research Center Tulane Lung Biology Program Tulane Bio-innovation Program Research interests include Nanobiotechnology, Molecular Recognition and Self-Assembly.
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OBJECTIVE: The preliminary classification criteria for antiphospholipid syndrome (APS), or the Sapporo criteria, are widely used for the inclusion of patients with APS into clinical studies. Revised Sapporo criteria have been proposed as an improved criteria set. Whether these criteria sets fulfill the current standards of measurement science are unknown. The purpose of this study was (1) to evaluate the developmental methodology and measurement properties of the Sapporo and the revised Sapporo criteria for use in clinical trials; and (2) to evaluate if the revised Sapporo criteria provide added value over the Sapporo criteria. METHODS: A computer search for articles describing use of the Sapporo and the revised Sapporo criteria was performed. Item generation, item reduction, sensibility, validity, and reliability of the criteria were evaluated. RESULTS: The Sapporo criteria set has incremental face and content validity over its predecessors. However, through separation of anti-ss2-glycoprotein ...
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