Ca2+ influx through voltage-dependent Ca2+ channels regulates vascular remodeling and contraction. However, the role of T-type Ca2+ channels (TCCs) has remained unknown in the ductus arteriosus (DA). Here we hypothesized that Ca2+ influx via TCC contributed to DA closure through promoting neointimal cushion formation and oxygen-induced vascular contraction. Quantitative RT-PCR analysis revealed that α1G, a TCC subtype, was significantly up-regulated in rat neonatal DA tissues at birth and in DA smooth muscle cells (SMCs) that were exposed to oxygen. The expression of α1G mRNA was higher in DA than in the aorta. Immunohistlogical analysis revealed that α1G was localized predominantly to the region of intimal thickening in fetal DA at term and to the central core of neonatal DA at birth. To examine the effects of blockade of TCCs, we used α1G-specific siRNA or R(−)-efonidipine, a highly selective TCC blocker that was recently developed. α1G-specific siRNAs inhibited SMC migration by 55% ...

L-type calcium channel blockers are used to treat hypertension. In most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypertension.[8]. T-type calcium channel blockers are used to treat epilepsy. Increased calcium conductance in the neurons leads to increased depolarization and excitability. This leads to a greater predisposition to epileptic episodes. Calcium channel blockers reduce the neuronal calcium conductance and reduce the likelihood of experiencing epileptic attacks.[9]. ...

Glioblastoma stem cells (GSCs) have been implicated in tumor resistance to radio- and chemotherapy. Proliferation of GSCs reportedly requires calcium influx through T-type calcium channels (Cav3.2). In this study we investigated the expression, function, mechanism of action and therapeutic targeting of Cav3.2 with the FDA approved and repurposed drug Mibefradil in glioblastoma (GBM), and GSCs. We found that Cav3.2 is highly expressed in the majority of human GBM specimens and all GCSs. TCGA data analysis demonstrated that approximately 11% of GBM tumors have upregulated Cav3.2 and that overexpression of Cav3.2 is associated with worse prognosis. Furthermore, we demonstrated that Mibefradil inhibits GSC growth and survival and sensitizes GSCs to Temozolomide (TMZ) chemotherapy. Mibefradil inhibited hypoxia inducible factor HIF1a and induced GSC differentiation. To investigate the mechanism of action of Mibefradil, were performed proteomic and transcriptomic screenings of Mibefradil-treated GSCs ...

The present study provides 2 major new findings. First, in contrast to its peripheral effects, centrally administered nifedipine decreases RSNA and HR in conscious SHR. Second, these sympathoinhibitory effects of nifedipine are enhanced in SHR on high versus regular sodium intake.. Dihydropyridine-sensitive, low-voltage-activated calcium channels have been demonstrated in rat brain neurons freshly isolated from regions such as the ventromedial hypothalamus.6 The role of the different types of calcium channels in neuronal synaptic transmission has not been clarified. In rat hippocampal cells,7 during neuronal activation postsynaptic or presynaptic Ca2+ entry involves the activation of the P/Q-, L-, or N-type Ca2+ channels but not the T-type Ca2+ channels. Unless dissolved in certain solvents such as dimethylsulfoxide,15 nifedipine blocks only L-type channels and has no effects on T-type channels in neuronal cells.8 15 In the present study nifedipine was dissolved in a vehicle containing no ...

Frequency of genetic polymorphism of calcium channels gene CACNA1C in healthy individuals and patients with arterial hypertension

TEMPLATE FILE FOR LTS CORTICAL PYRAMIDAL CELL --------------------------------------------- One compartment model and currents derived from: Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., Bal, T., Fregnac, Y., Markram, H. and Destexhe, A. Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons. Biological Cybernetics 99: 427-441, 2008. Model taken from: Destexhe, A. Contreras, D. and Steriade, M. LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38: 555-563 (2001). - one compartment model - passive - HH Traub - IM - T-type calcium current Alain Destexhe, CNRS, 2008 --------------------------------------------------------------*/ print print ,, defining template for one-compartment sPYr cell ,, print begintemplate sPYr // create a new template object public soma create soma[1] proc init() { local v_potassium, v_sodium v_potassium = -100 // potassium reversal potential v_sodium = 50 ...

When neuronal activity is reduced over a period of days, compensatory changes in synaptic strength and/or cellular excitability are triggered, which are thought to act in a manner to homeostatically recover normal activity levels. The time course over which changes in homeostatic synaptic strength and cellular excitability occur are not clear. Although many studies show that 1-2 days of activity block are necessary to trigger increases in excitatory quantal strength, few studies have been able to examine whether these mechanisms actually underlie recovery of network activity. Here, we examine the mechanisms underlying recovery of embryonic motor activity following block of either excitatory GABAergic or glutamatergic inputs in vivo. We find that GABAA receptor blockade triggers fast changes in cellular excitability that occur during the recovery of activity but before changes in synaptic scaling. This increase in cellular excitability is mediated in part by an increase in sodium currents and a reduction

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The combination of the nonspecific F-type channels and the closing of K+ channels results in a steady depolarization when membrane potential is negative, these channels paired with the effects of T-type Ca+2 channels allow recurring depolarization following repolarization and therefore facilitate the pacemaker ...

Abstract: We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DZero detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process ppbar-,tb+X of 39 pb. The upper limit for the t-channel process ppbar-,tqb+X is 58 pb ...

Analysis of the Wtb vertex from the measurement of triple-differential angular decay rates of single top quarks produced in the t-channel at $\sqrt{s}=8$ TeV with the ATLAS detector / M. Aaboud, [et al.], L. ADAMCZYK, [et al.], T. BOŁD, [et al.], W. DĄBROWSKI, [et al.], G. P. GACH, [et al.], I. GRABOWSKA-BOŁD, [et al.], M. P. GUZIK, [et al.], P. A. JANUS, [et al.], D. KISIELEWSKA, [et al.], S. KOPERNY, [et al.], T. Z. KOWALSKI, [et al.], J. A. KREMER, [et al.], B. MINDUR, [et al.], M. PRZYBYCIEŃ, [et al.], A. ZEMŁA, [et al.] // The Journal of High Energy Physics ; ISSN 1126-6708. - 2017 iss. 12 art. no. 017, s. [1], 1-59. - Bibliogr. s. 37-42, Abstr.. - Publikacja dostępna online od: 2017-12-04. - tekst: https://goo.gl/XXSNDX ...

A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous as voltage-gated calcium channel, although there are also ligand-gated calcium channels. The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated. the receptor-operated calcium channels (in vasoconstriction) P2X receptors L-type calcium channel blockers are used to treat hypertension. In most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypertension. T-type calcium channel blockers are used to treat epilepsy. Increased calcium conductance in ...

Injection of NMDAR antagonist into the thalamus can produce delta frequency EEG oscillations in the thalamocortical system. It is surprising that an antagonist of an excitatory neurotransmitter should trigger such activity, and the mechanism is unknown. One hypothesis is that the antagonist blocks excitation of GABAergic cells, thus producing disinhibition. To test this hypothesis, we investigated the effect of NMDAR antagonist (APV) on cells of the nucleus reticularis (nRT) in rat brain slices, a thalamic nucleus that can serve as a pacemaker for thalamocortical delta oscillations and that is composed entirely of GABAergic neurons. We found, unexpectedly, that nRT cells are hyperpolarized by APV. This occurs because these cells have an unusual form of NMDAR (probably NR2C) that contributes inward current at resting potential in response to ambient glutamate. The hyperpolarization produced by APV is sufficient to deinactivate T-type calcium channels, and these trigger rhythmic bursting at delta

ID F7H6P3_MACMU Unreviewed; 2291 AA. AC F7H6P3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 25-OCT-2017, entry version 36. DE RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256,RuleBase:RU003808}; GN Name=CACNA1G {ECO:0000313,Ensembl:ENSMMUP00000034848}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313,Ensembl:ENSMMUP00000034848, ECO:0000313,Proteomes:UP000006718}; RN [1] {ECO:0000313,Ensembl:ENSMMUP00000034848, ECO:0000313,Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313,Ensembl:ENSMMUP00000034848, RC ECO:0000313,Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis ...

ID I3N0U5_ICTTR Unreviewed; 1770 AA. AC I3N0U5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 27-SEP-2017, entry version 37. DE RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256,RuleBase:RU003808}; GN Name=CACNA1I {ECO:0000313,Ensembl:ENSSTOP00000017991}; OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) OS (Spermophilus tridecemlineatus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; OC Sciuridae; Xerinae; Marmotini; Ictidomys. OX NCBI_TaxID=43179 {ECO:0000313,Ensembl:ENSSTOP00000017991, ECO:0000313,Proteomes:UP000005215}; RN [1] {ECO:0000313,Ensembl:ENSSTOP00000017991} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG The Broad Institute Genome Assembly & Analysis Group; RG Computational R&D Group; RG and Sequencing Platform; RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D., RA MacCallum ...

학술회의] 민철기, Hae-Kwon Kim, Jae-Ho Lee, Yun-Jin Jung, Kyoo Wan Choi, Seung-Jae Lee, Sung Eun Lee, Hwa Lee Ryu, Ju-Hee Lee, Inhibitory action of mibefradil on steroidogenesis in mouse leydig cells: involvement of Ca+2 entry through T-type Ca+2 channels in steroidogenesis , ESHRE 21st Annual Meeting , Vol.21 , pp.121 -121 (Jun, 2005) ...

Procedure for localizing T-current in distal dendrites - Reconstructed thalamic RE cell with 80 compartments (re80) - currents must be localized everywhere first parameter: somatic and proximal dendritic conductance secnd parameter: medial dendritic conductance third parameter: distal dendritic conductance ----------------------------------------------------------------------*/ proc localize() { /* CHANGE ALL : */ forall { gcabar_it2 = $3 } /* CHANGE SOMA : */ soma.gcabar_it2 = $1 /* CHANGE PROXIMAL SEGMENTS : */ dend1[0].gcabar_it2 = $1 dend1[1].gcabar_it2 = $1 dend1[2].gcabar_it2 = $1 dend1[22].gcabar_it2 = $1 dend2[0].gcabar_it2 = $1 dend3[0].gcabar_it2 = $1 dend4[0].gcabar_it2 = $1 /* CHANGE MEDIAL SEGMENTS : */ dend1[3].gcabar_it2 = $2 dend1[16].gcabar_it2 = $2 dend1[17].gcabar_it2 = $2 dend1[18].gcabar_it2 = $2 dend1[19].gcabar_it2 = $2 dend1[23].gcabar_it2 = $2 dend1[34].gcabar_it2 = $2 dend2[1].gcabar_it2 = $2 dend2[4].gcabar_it2 = $2 dend3[1].gcabar_it2 = $2 dend3[10].gcabar_it2 = $2 ...

Joksovic PM, Brimelow BC, Murbartián J, Perez-Reyes E, Todorovic SM. Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol. 2005 Jan; 144(1):59-70 ...

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References for Abcams Recombinant Human CA8 protein (ab123192). Please let us know if you have used this product in your publication

TY - JOUR. T1 - Ca2+ channel subtypes and pharmacology in the kidney. AU - Hayashi, Koichi. AU - Wakino, Shu. AU - Sugano, Naoki. AU - Ozawa, Yuri. AU - Homma, Koichiro. AU - Saruta, Takao. PY - 2007/2/1. Y1 - 2007/2/1. N2 - A large body of evidence has accrued indicating that voltage-gated Ca channel subtypes, including L-, T-, N-, and P/Q-type, are present within renal vascular and tubular tissues, and the blockade of these Ca channels produces diverse actions on renal microcirculation. Because nifedipine acts exclusively on L-type Ca channels, the observation that nifedipine predominantly dilates afferent arterioles implicates intrarenal heterogeneity in the distribution of L-type Ca channels and suggests that it potentially causes glomerular hypertension. In contrast, recently developed Ca channel blockers (CCBs), including mibefradil and efonidipine, exert blocking action on L-type and T-type Ca channels and elicit vasodilation of afferent and efferent arterioles, which suggests the ...

Dopaminergic neurons of the substantia nigra pars compacta (SNc) are involved in the control of movement, sleep, reward, learning, and nervous system disorders and disease. To date, a thorough characterization of the ion channel phenotype of this important neuronal population is lacking. Using immunohistochemistry, we analyzed the somatodendritic expression of voltage-gated ion channel subunits that are involved in pacemaking activity in SNc dopaminergic neurons in 6-, 21-, and 40-day-old rats. Our results demonstrate that the same complement of somatodendritic ion channels is present in SNc dopaminergic neurons from P6 to P40. The major developmental changes were an increase in the dendritic range of the immunolabeling for the HCN, T-type calcium, Kv4.3, delayed rectifier, and SK channels. Our study sheds light on the ion channel subunits that contribute to the somatodendritic delayed rectifier (Kv1.3, Kv2.1, Kv3.2, Kv3.3), A-type (Kv4.3) and calcium-activated SK (SK1, SK2, SK3) potassium ...

At supratherapeutic doses (2- to 5-fold), the T-type Ca2+antagonist mibefradil modifies the T/U wave of the human ECG. In this study, we show that this effect is observed in conscious monkeys and is duplicated by verapamil or diltiazem. We then evaluate the proarrhythmic risk of such alterations of cardiac repolarization by examining the actions of mibefradil on cardiac action potentials (APs). In isolated cardiomyocytes from guinea pigs or humans, mibefradil dose dependently shortens the plateau of the AP; this effect is similar to other Ca2+ antagonists and opposite to drugs having class III antiarrhythmic properties. The metabolites of mibefradil, singly or in combination, also shorten APs. In isolated rabbit hearts, noncardiodepressant concentrations of mibefradil have no effect on monophasic action potentials (MAPs), whereas cardiodepressant levels produce a slight nonsignificant lengthening. In hearts of open-chest bradycardic dogs, mibefradil has no effect on MAP dispersion or on QT ...

Efonidipine (INN) is a dihydropyridine calcium channel blocker marketed by Shionogi & Co. of Japan. It was launched in 1995, under the brand name Landel. The drug blocks both T-type and L-type calcium channels. It has also been studied in atherosclerosis and acute renal failure.

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Mouse monoclonal antibody raised against a full-length recombinant CA13. CA13 (NP_940986.1, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00377677-M) - Products - Abnova

Contractions induced by 10 nM endothelin-1 (ET) in the rabbit aortic media intimal layer were inhibited by prior exposure to 100 microM Ni++ (33.1%) or to a Ca(++)-free buffer (80.2%) but were unaffected by pretreatment with 0.1 microM nifedipine. Contractions elicited by phenylephrine (1 nM-100 microM) or K+ (10-50 mM) were not inhibited by 100 microM Ni++ but those induced by ET in tissues submaximally precontracted with 20 mM K+ were selectively antagonized by the divalent cation. The mechanism for the inhibitory action of Ni++ was ascertained by an examination of the effects of the cation on ET-induced alterations in the cellular distribution and mobilization of Ca++. Efflux of 45Ca from the muscle into a solution without added Ca++ was not altered by ET. Total or cellular 45Ca uptake (uptake after exposure to La and low temperature), at either low- or high-affinity sites in resting muscles was also not affected by the peptide. However, low-affinity cellular 45Ca retention in muscles ...

White bass (Roccus chrysops) retinal horizontal cells possess two types of voltage-activated calcium currents which have recently been characterized with regard to their voltage dependence and pharmacology (Sullivan, J., and E. M. Lasater. 1992. Journal of General Physiology. 99:85-107). A low voltage-activated transient current was identified which resembles the T-type calcium current described in a number of other preparations, along with a sustained high threshold, long-lasting calcium current that resembles the L-type calcium current. Here we report on the modulation of horizontal cell calcium channels by dopamine. Under whole-cell voltage clamp conditions favoring the expression of both calcium currents, dopamine had opposing actions on the two types of voltage-sensitive calcium currents in the same cone-type horizontal cell. The L-type calcium current was significantly potentiated by dopamine while the T-type current was simultaneously reduced. Dopamine had no effect on calcium currents in ...

The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channels properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene. They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus. They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics. Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit. Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP (May 1993). Structure and functional expression of a member of the low voltage-activated calcium channel family. Science. 260 (5111): 1133-6. doi:10.1126/science.8388125. PMID ...

TY - JOUR. T1 - Venom from Anemesia species of spider modulates high voltage-activated Ca2+ currents from rat cultured sensory neurones and excitatory post synaptic potentials from rat hippocampal slices.. AU - Kalikulov, D.. AU - Ayar, A.. AU - Nuritova, F.. AU - Frenguelli, B. G.. AU - McClelland, David. AU - Davidson, I.. AU - Scott, Roderick Hamilton. PY - 2001. Y1 - 2001. N2 - The actions of crude venom from Anemesia species of spider were investigated in cultured dorsal root ganglion neurones from neonatal rats and hippocampal slices. Using mass spectrometry (MALDI-TOF MS), 10-12 distinct peptides with masses between about 3 and 10 kDa were identified in the crude spider venom. At a concentration of 5 mug/ml crude Anemesia venom transiently enhanced the mean peak whole cell voltage-activated Ca2+ current in a voltage-dependent manner and potentiated transient increases in intracellular Ca2+ triggered by 30 mM KCI as measured using Fura-2 fluorescence imaging. Additionally, 5-8 mug/ml ...

L-type (CaV1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 gene by the transcript-scanning method revealed 19 of the 55 exons were subjected to alternative splicing, and two of these were novel exons. A large IVS3-S4 variability resulting from combinatorial utilization of exons 31-33 demonstrated a correlation between increased IVS3-S4 linker length and more depolarized activation potentials.Sixty-four splicing profiles of CaV1.2 alpha-1 subunit were identified from 6 full-length cDNA libraries generated from heart and aortic tissues of the Spontaneously Hypertensive Rats and Wistar Kyoto Rats. The tissue-selective and pathologically induced splicing profiles of 10 alternatively spliced exons assessed indicated a striking alteration in exon utilization and ...

Low-voltage-activated calcium channels in the lamprey locomotor network: simulation and experiment. J. Neurophysiol. 77: 1795-1812, 1997. To evaluate the role of low-voltage-activated (LVA) calcium channels in the lamprey spinal locomotor network, a previous computer simulation model has been extended to include LVA calcium channels. It is also of interest to explore the consequences of a LVA conductance for the electrical behavior of the single neuron. The LVA calcium channel was modeled with voltage-dependent activation and inactivation using the m 3 h form, following a Hodgkin-Huxley paradigm. Experimental data from lamprey neurons was used to provide parameter values of the single cell model. The presence of a LVA calcium conductance in the model could account for the occurrence of a rebound depolarization in the simulation model. The influence of holding potential on the occurrence of a rebound as well the latency at which it is elicited was investigated and compared with previous ...

Background- Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression of T-type Ca2+ channels contributes to the progression of heart failure. The ability of T-type Ca2+ channel blockade to prevent lethal arrhythmias associated with heart failure has never been tested, however.. Methods and Results- We compared the effects of efonidipine and mibefradil, dual T- and L-type Ca2+ channel blockers, with those of nitrendipine, a selective L-type Ca2+ channel blocker, on survival and arrhythmogenicity in a cardiac-specific, dominant-negative form of neuron-restrictive silencer factor transgenic mice (dnNRSF-Tg), which is a useful mouse model of dilated cardiomyopathy leading to sudden death. Efonidipine, but not nitrendipine, substantially improved survival among dnNRSF-Tg mice. Arrhythmogenicity was dramatically reduced in dnNRSF-Tg mice treated with efonidipine or ...

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RecName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-4;AltName: Full=Voltage-gated calcium channel subunit alpha-2/delta-4;Contains: RecName: Full=Voltage-dependent calcium channel subunit alpha-2-4;Contains: RecName: Full=Voltage-depen ...

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The superficial spinal dorsal horn contains a heterogeneous population of neurons that process sensory inputs. Information on the properties of excitatory interneurons in this region is limited. As calretinin is a protein thought to be restricted to an excitatory population in this region, the aim of this study was to characterize calretinin-expressing neurons. Most calretinin cells (85%) exhibited large A-type potassium currents and delayed firing action potential discharge, and received strong excitatory synaptic input, whereas the remainder exhibited hyperpolarization-activated cation currents and low threshold T-type calcium currents, and tonic- or initial bursting firing patterns, and received weak excitatory synaptic input. These respective features are consistent with properties of excitatory and inhibitory interneuron populations in this region of the spinal cord. Our findings have resolved a previously unidentified population of inhibitory interneurons. Furthermore, the contrasting ...

TY - JOUR. T1 - Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons. T2 - A model study. AU - Xu, Jun. AU - Clancy, Colleen E. PY - 2008/4/30. Y1 - 2008/4/30. N2 - A critical property of some neurons is burst firing, which in the hippocampus plays a primary role in reliable transmission of electrical signals. However, bursting may also contribute to synchronization of electrical activity in networks of neurons, a hallmark of epilepsy. Understanding the ionic mechanisms of bursting in a single neuron, and how mutations associated with epilepsy modify these mechanisms, is an important building block for understanding the emergent network behaviors. We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation. The single compartment model incorporates accurate representations of sodium (Na+) channels (Nav1.1) and T-type calcium ...

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Fingerprint Dive into the research topics of Receptor-operated, but not voltage-operated, calcium channels are involved in basophil leucocyte activation and histamine release. Together they form a unique fingerprint. ...

The objective of this study was to begin to examine the cellular and biophysical effects on human retinal glial cells of basic fibroblast growth factor (bFGF), which is endogenous to the retina and likely to play a role in retinal pathobiology. Experiments were performed on cultured glial cells derived from the adult postmortem retina. A proliferative response to bFGF established a sensitivity of the retinal glia to this growth factor. The possibility that bFGF alters calcium currents was assessed using the whole-cell recording configuration of the patch-clamp technique to analyze inward currents carried by barium. Two types of voltage-gated calcium channels could be expressed by the glial cells. One, similar to the T-type current described in various kinds of cells, had a low threshold of activation, a transient response, and an insensitivity to the dihydropyridine nifedipine. The other type of inward current, which closely resembles the L-type calcium current found in other cells, had a high ...

Oxygen is one of the most important molecules on Earth mainly because of the biochemical symmetry of oxygenic photosynthesis and aerobic respiration that can maintain homeostasis within our planet's biosphere. Oxygen can also produce toxic molecules, reactive oxygen species (ROS). ROS play a dual role in biological systems, since they can be either harmful or beneficial to living systems. They can be considered a double-edged sword because at moderate concentrations, nitric oxide (NO•), superoxide anion, and related reactive oxygen species play an important role as regulatory mediators in signalling processes. Many of the ROS-mediated responses actually protect the cells against oxidative stress and re-establish redox homeostasis. On the other hand, overproduction of ROS has the potential to cause damage. In the recent decades, ROS has become a focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence from research on several diseases ...

Liao, P., Yu, D., Li, G., Tan, F.Y., Tuck, W.S., Jia, L.S., Yeow, L.C. (2007). A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. Journal of Biological Chemistry 282 (48) : 35133-35142. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc. ...

The IUPHAR/BPS Guide to Pharmacology. Cav1.3 - Voltage-gated calcium channels. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.

RGK regulation of voltage-gated calcium channels. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Voltage-dependent calcium channel subunit alpha-2/delta-1 (CA2D1) antibody | P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3

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Can anyone recommend any newsgroups dealing with calcium channel of SR? Thank you in advance for your help. ssultang (in english, sugar ...

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View mouse Cacna1s Chr1:136052805-136119822 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

CRESTRON CNXRY 16 PDF - The Crestron CNXRY installs in any Y-Bus expansion slot of a 2-Series control system to provide 16 isolated, low-voltage relay closures. Each group of