TY - JOUR. T1 - Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis. AU - Dunlay, R.. AU - Rodriguez, M.. AU - Felsenfeld, A. J.. AU - Llach, F.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The effect of intravenous calcitriol on parathyroid function was evaluated in nine chronic hemodialysis patients with secondary hyperparathyroidism. Two micrograms of calcitriol were administered intravenously after dialysis thrice weekly for ten weeks. Parathyroid function was assessed by inducing hypo- and hypercalcemia with low calcium (1.0 mEq/liter) and high calcium (4.0 mEq/liter) dialyses before and after ten weeks of intravenous calcitriol therapy. To avoid hypercalcemia during calcitriol administration, the dialysate calcium was reduced to 2.5 mEq/liter. Parathyroid hormone (PTH) values (pg/ml) from dialysis-induced hypo- and hypercalcemia were plotted against serum ionized calcium, and the sigmoidal relationship between PTH and calcium was evaluated. Basal PTH levels ...
TY - JOUR. T1 - Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. AU - Christensen, G L. AU - Jepsen, J S. AU - Fog, C K. AU - Christensen, I J. AU - Lykkesfeldt, A E. PY - 2004/5. Y1 - 2004/5. N2 - Development of resistance to antihormonal therapy is a major problem in the treatment of breast cancer patients. Metastatic tumors, which progress after a period of response to treatment, often respond to second line endocrine treatment, but eventually develop estrogen independent growth. Vitamin D analogues are promising new drugs, using alternative mechanisms to inhibit growth of breast cancer cells. The sensitivity to antiestrogens and vitamin D analogues has been proposed to be inverse, indicating that the sensitivity to vitamin D analogues might increase after development of antiestrogen resistance and vice versa. In this study, the inverse sensitivity between ...
Hostutler, R. A., DiBartola, S. P., Chew, D. J., Nagode, L. A., Schenck, P. A., Rajala-Schultz, P. J. and Drost, W. T. (2006), Comparison of the Effects of Daily and Intermittent-Dose Calcitriol on Serum Parathyroid Hormone and Ionized Calcium Concentrations in Normal Cats and Cats with Chronic Renal Failure. Journal of Veterinary Internal Medicine, 20: 1307-1313. doi: 10.1111/j.1939-1676.2006.tb00743.x ...
1,25 Dihydroxyvitamin D circulating levels, calcitriol administration, and incidence of acute rejection, CMV infection, and polyoma virus infection in renal transplant recipients ...
To clarify the effects of active vitamin D3 on pressor and vascular responses to vasoconstrictor substances, we studied pressor responses to the intravenous injection of norepinephrine or angiotensin II (Ang II) and vasoconstrictor responses to norepinephrine. Sprague-Dawley rats were given 1,25-dihydroxyvitamin D3 subcutaneously (200 ng/kg per day) for 14 days. The administration of 1,25-dihydroxyvitamin D3 augmented the pressor responses to norepinephrine and Ang II in conscious rats and was associated with a significant increase in serum calcium concentration (11.0 +/- 0.2 mg/dl). To further clarify whether the increased pressor response to vasoconstrictors may be due to the calcemic or direct action of active vitamin D3, we studied the effect of its noncalcemic analogue, 22-oxacalcitriol, and its inactive analogue, 24,25-dihydroxyvitamin D3, on the pressor response to vasoconstrictors in rats. The pressor responses to norepinephrine and Ang II were apparently augmented in ...
OUTLINE: This is a dose-escalation study of calcitriol.. In the first stage of the study, cohorts of 3-6 patients receive escalating doses of oral calcitriol on days 1-3. Dose escalation continues until the maximum tolerated dose (MTD) is determined.. In the second stage, patients receive escalating doses of oral calcitriol on days 1-3 and a fixed dose of oral dexamethasone on days 0-4. Treatment continues weekly in the absence of disease progression or unacceptable toxicity. Dose escalation continues until the MTD is determined.. Six additional patients may receive calcitriol and dexamethasone at one dose level below the MTD determined in the second stage, to confirm the MTD.. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.. PROJECTED ACCRUAL: Approximately 40 patients will be accrued for this study. ...
To elucidate the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone, two known metabolites of 25-hydroxyvitamin D3--23,25-dihydroxyvitamin D3 and 25,26-dihydroxyvitamin D3--were incubated individually with kidney homogenate prepared from vitamin D-supplemented chickens, a preparation known to produce the lactone from 25-hydroxyvitamin D3. The 25-hydroxyvitamin D3-26,23-lactone produced in vitro was then separated, purified, identified, and quantitated by consecutive straight-phase and reverse-phase high-performance liquid chromatography. 23,25-Dihydroxyvitamin D3 is a far better substrate for production of 25-hydroxyvitamin D3-26,23-lactone than is 25,26-dihydroxyvitamin D3. Production of lactone is highly selective for the natural 23(S)-hydroxy-23,25-dihydroxyvitamin D3 while both epimers of 25,26-dihydroxyvitamin D3 resulted in small amounts of product comigrating with natural lactone. It appears that 23(S),25-dihydroxyvitamin D3, but not 25,26-dihydroxyvitamin D3, is a natural precursor in ...
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DN-101 is an investigational drug that has not been approved by the U.S. Food and Drug Administration (FDA). It is a newly formulated pill that contains high amounts of calcitriol, a naturally occurring hormone and the biologically active form of vitamin D. Administration of DN-101 results in much higher blood levels of calcitriol than the body can produce from dietary vitamin D or vitamin D supplements. These higher levels of calcitriol are associated with anti-cancer effects in laboratory models of human cancer. Laboratory models also indicate that calcitriol has synergy with many commonly used chemotherapeutic agents used to treat cancer.. Calcitriol, at very low doses, is currently approved for use in patients with chronic kidney failure. DN-101 was specifically designed for cancer and contains 30 times the amount of calcitriol found in the calcitriol pill commercially available today. In order to take an amount of calcitriol equivalent to 1 DN-101 pill, cancer patients would need to swallow ...
Calcitriol ,Calcitriol manufacturer,Calcitriol CAS No 32222-06-3,Calcitriol Molecular Formula C27H44O3,Calcitriol Synonyms (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol,Calcitriol Molecular weight 416.64 g/mol,Calcitriol manufacturing by A.S.Joshi & Company
Ongoing studies are attempting to determine the optimal combination of calcimimetics and calcitriol analogs for the treatment of SHPT. The ACHIEVE study recently compared the effects of Cinacalcet plus fixed low-dose calcitriol analogs with flexible doses of calcitriol analogs on PTH, Ca, and P levels (25). In this study, we used samples from ACHIEVE to perform a per-protocol analysis of the effects of treatment on FGF23, a factor associated with poor outcomes in ESRD (15). We found that the treatment regimen using Cinacalcet plus fixed low-dose calcitriol analogs results in a relative decrease in FGF23 levels compared with an approach using escalating doses of calcitriol analogs alone. This study is the first report of the disparate effects of different treatment strategies on FGF23 levels in HD patients.. The existence of complex interactions between treatment agents and mineral metabolic parameters make it difficult to ascribe the observed differences in FGF23 to a specific therapeutic ...
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TY - JOUR. T1 - The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1α,25- dihydroxyvitamin D2 as therapeutic agents for prostate cancer. AU - Chen, Tai C.. AU - Schwartz, Gary G.. AU - Burnstein, Kerry L.. AU - Lokeshwar, Bal L.. AU - Holick, Michael F.. PY - 2000/3/1. Y1 - 2000/3/1. N2 - Prostate cancer cells contain specific receptors [vitamin D receptors (VDRs)] for 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), which is known to inhibit the proliferation and invasiveness of these cells. These findings support the use of 1α,25(OH)2D3 for prostate cancer therapy. However, because 1α,25(OH)2D3 can cause hypercalcemia, analogues of 1α,25(OH)2D3 that are less calcemic but that exhibit potent antiproliferative activity would be attractive as therapeutic agents. We investigated the effects of two different types of less calcemic vitamin D compounds, 25-hydroxyvitamin D3 [25(OH)D3] and 19-nor-1α,25-dihydroxyvitamin D2 [19-nor-1,25(OH)2D2], and compared their activity to 1α,25(OH)2D3 on ...
AbstractAfter the Second World War, infatuation with modern products has exponentially widened the spectrum of chemicals used. Some of them are capable of hijacking the endocrine system by blocking or imitating a hormone and are referred to as hormonally active chemicals or endocrine disruptors. These are chemicals that the body was not designed for evolutionarily and they are present in every matrix of the environment. We are living in a chemical world where the exposures are ubiquitous and take place in combinations that can interact with the endocrine system and some other metabolic activities in unexpected ways. The complexity of interaction of these compounds can be understood by the fact that they interfere with gene expression at extremely low levels, consequently harming an individual life form, its offspring or population. As the endocrine system plays a critical role in many biological or physiological functions, by interfering bodys endocrine system, endocrine disrupting compounds (EDCs)
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Calcitriol or 1,25-dihydroxycholecalciferol (abbreviated 1,25-(OH)2-D3) is the active form of vitamin D found in the body (vitamin D3). Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis). It is produced in the kidneys via 25-hydroxyvitamin D-1 α-hydroxylase by conversion from 25-hydroxycholecalciferol (calcidiol). This is stimulated by a decrease in serum calcium, phosphate (PO43−) and parathyroid hormone (PTH) levels. It regulates calcium levels by increasing the absorption of calcium and phosphate from the gastrointestinal tract, increasing calcium and phosphate reabsorption in the kidneys and inhibiting the release of PTH. Calcitriol is also commonly used as a medication in the treatment of hypocalcemia and osteoporosis.
Calcitriol Receptors: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.. If you are being treated with dialysis (process of cleaning the blood by passing it through a machine), your doctor may also prescribe a low-phosphate diet. Follow these directions carefully.. If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. If you have kidney disease, talk to your doctor about how much fluid you should drink each day.. ...
Calcitriol will work only if you get the right amount of calcium from the foods you eat. If you get too much calcium from foods, you may experience serious side effects of calcitriol, and if you do not get enough calcium from foods, calcitriol will not control your condition. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. If you find it difficult to eat enough of these foods, tell your doctor. In that case, your doctor can prescribe or recommend a supplement.. If you are being treated with dialysis (process of cleaning the blood by passing it through a machine), your doctor may also prescribe a low-phosphate diet. Follow these directions carefully.. If you do not have kidney disease, you should drink plenty of fluids while taking calcitriol. If you have kidney disease, talk to your doctor about how much fluid you should drink each day.. ...
Before Its News). Market Research Store has been recently published a fresh research report- Global Calcitriol (CAS 32222-06-3) Market by Manufacturers, Countries, Type and Application, Forecast to 2022 . This added to the companys collection of research reports. This report offers a deep examination of the Calcitriol market for the period 2013-2023. As per the report, the Calcitriol market is estimated to grow at elevated CAGR recorded in 2017. The towering competitive Calcitriol market has been observing huge and whooping investments in development and research from government as well as private firms.. This report divides the market on the basis of regions, manufacturers, application, and type. It also showcases the growing factors, reasons for decline in the market, segmentations, and openings and breaks expected to power the market expansion during this time span. The primary factors such as revenues, supply chain management, product valuation and other crucial factors are also examined ...
TY - JOUR. T1 - Electromechanical effects of 1,25-dihydroxyvitamin D with antiatrial fibrillation activities. AU - Hanafy, Dicky A.. AU - Chang, Shih Lin. AU - Lu, Yen Yu. AU - Chen, Yao Chang. AU - Kao, Yu Hsun. AU - Huang, Jen Hung. AU - Chen, Shih Ann. AU - Chen, Yi Jen. PY - 2014. Y1 - 2014. N2 - Electromechanical Effects of 1,25-Dihydroxyvitamin D on the LA Introduction Treatment with 1,25-dihydroxyvitamin D (1,25[OH]2D) has several cardiovascular benefits. 1,25[OH]2D has direct cellular effects, but its effects on the atrium are not clear. We evaluated the effects of 1,25[OH]2D on the atrial electrophysiology and atrial fibrillation (AF). Methods Conventional microelectrodes were used to record action potentials (APs) and contractility in isolated rabbit left atrium (LA) tissue preparations before and after the administration of 0.01, 0.1, and 1 nM 1,25[OH] 2D with and without rapid atrial pacing (RAP) and acetylcholine (5 mM)-induced AF. Surface ECG and intracardiac electrograms were ...
Herein, we describe a versatile and efficient total synthesis of 1α,25-dihydroxyvitamin D3 (calcitriol). The synthetic strategy relies on an unprecedented Si-assisted SN2′-syn displacement of carbamates by cuprates to set the challenging pivotal quaternary methyl group at the fused-ring junction of the CD-tr
Breast cancer is the second leading cause of cancer deaths among females and a leading cause of death of all middle age women in the United States. Epidemiologic evidence suggests a role for vitamin D deficiency in the development of breast cancer. Moreover, vitamin D receptors have been found in most breast cancers, and their presence appears to be a favorable prognostic sign. While much clinical focus has been given to the vitamin A related retinoids, little is known about the role for vitamin D in the development of breast cancer although vitamin D and its active metabolites and analogs represent a class of compounds which at the molecular and cellular level have strong similarities to the vitamin A metabolites and analogs. With the development of potent but non hypercalcemic analogs of vitamin D, the potential role of vitamin D in the etiology and treatment of breast cancer can now be tested both in vitro and in vivo. In the past decade, a number of tissues have been found to contain receptors for
Calcitriol (ergocalciferol, 1,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D3) is a synthetic form of vitamin D[1]. Calcitriol causes increased calcium absorption from the gut. This product is used for treatment of hypocalcemia associated with rickets and hypoparathyroidism[2]. Regular monitoring of blood calcium is important to avoid development of hypercalcemia. Recommended dose in dogs is 25,000 - 50,000 U/day given orally[3]. ...
We have examined the effects of the seco-steroid hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on membrane phosphoinositide metabolism, protein kinase C (PKC) activation and influx of extracellular Ca2+ in chick-embryo muscle-cell (myoblast) cultures. At physiological concentrations, the hormone induces a rapid (15 s) and transient release of inositol triphosphate (InsP3) and diacylglycerol (DAG). InsP3 release is maximal at 60 s (80% above controls) and then declines. The effects of 1,25(OH)2D3 on InsP3 production exhibited specificity, as 25-hydroxy-vitamin D3 and 24,25-dihydroxy-vitamin D3 did not alter myoblast InsP3 levels. The stimulation of DAG is biphasic, with peaks at 60 s (+105%) and 5 min (+700%). The second phase of DAG release is not associated with changes in InsP3. 1,25(OH)2D3 induces a rapid (within 60 s) accumulation of InsP2, and its effect on InsP is delayed (120 s). The hormone rapidly activates myoblast PKC, with maximal translocation of activity from the cytosol to the ...
TY - JOUR. T1 - Phase I study of weekly DN-101, a new formulation of calcitriol, in patients with cancer. AU - Beer, Tomasz (Tom). AU - Javle, Milind M.. AU - Ryan, Christopher. AU - Garzotto, Mark. AU - Lam, Gilbert N.. AU - Wong, Alvin. AU - Henner, W. David. AU - Johnson, Candace S.. AU - Trump, Donald L.. PY - 2007/4. Y1 - 2007/4. N2 - Background: DN-101 is a new, high-dose, oral formulation of calcitriol under investigation for the treatment of cancer. We sought to evaluate the tolerability and pharmacokinetics (PK) of weekly doses of DN-101 in patients with advanced cancer. Methods: Patients who completed a previously reported single dose escalation study of DN-101 [Beer et al. (2005) Clin Cancer Res 11:7794-7799] were eligible for this continuation weekly dosing study. Cohorts of 3-10 patients were treated at doses of 15, 30, 45, 60, and 75 μg calcitriol. Once 45 μg was established as the maximum tolerated dose (MTD), this cohort was expanded to include 18 patients. Dose limiting ...
Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment," says senior author Ronald M. Evans, a professor in Salks Gene Expression Laboratory and lead researcher in the Institutes new Helmsley Center for Genomic Medicine. The Salk study focused on a star-shaped "stellate" cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases. The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. "Preclinical results suggest the vitamin D brake is highly efficacious and led us to believe that the time is right to consider a trial in the context of ...
TY - JOUR. T1 - C-terminal proteolysis of the avian 1,25-dihydroxyvitamin D3 receptor. AU - Allegretto, Elizabeth A.. AU - Pike, J. Wesley. AU - Haussler, Mark R.. PY - 1987/8/31. Y1 - 1987/8/31. N2 - Exposure of the 60 kDa chick intestinal 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor to carboxypeptidase A resulted in a time dependent decrease in receptor hormone-binding; after 2 h, there was no detectable macro-molecular-bound 1,25(OH)2[3H]D3. Upon DNA-cellulose chromatography of this preparation, a 56 kDa protein adsorbed to the column and eluted as a function of para-chloromercuribenzene sulfonate (a sulfhydryl blocking reagent). The 56 kDa fragment was detected by anti-receptor monoclonal antibodies via immunoblot technology. The 1,25(OH)2[3H]D3 eluted in the fall through fractions of the column. Thus, cleavage of up to 40 amino acids from the carboxy-terminus of the 1,25(OH)2D3 receptor results in a protein which no longer binds to hormone, but retains its capacity to interact with ...
Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving...
Avet Pharmaceuticals Inc. announced the immediate availability of Calcitriol soft gel capsules in 0.25 and 0.5 mcg strengths. This product is the AB rated generic equivalent to the synthetic Vitamin D drug Rocaltrol®* and adds to Avets robust portfolio of generic oral soft gel products. According to IMS data for the twelve-months ended April 2013, the U.S. market for Calcitriol approximated $60 million. *Rocaltrol is a registered trademark of Hoff-mann LaRoche-Validus.. Download Press Release. ...
The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis of variation in the immunomodulatory effects of 1,25D, we mapped quantitative traits of 1,25D response at both the cellular and the transcriptional level. We carried out a genome-wide association scan of percent inhibition of cell proliferation (Imax) induced by 1,25D treatment of peripheral blood mononuclear cells from 88 healthy African-American individuals. Two genome-wide significant variants were identified: rs1893662 in a gene desert on chromosome 18 (p = 2.32 x 10−8) and rs6451692 on chromosome 5 (p = 2.55 x 10−8), which may influence the anti-proliferative activity of 1,25D by regulating the expression of nearby genes such as the chemokine gene, CCL28, and the translation initiation gene, PAIP1. We also identified 8 expression ...
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The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). In order to investigate early effects on the differentiation process of MO, we used the mRNA Differential Display technology to identify genes that are induced in freshly isolated human blood MO cultured for 4 hours with Vitamin D3. A cDNA fragment was isolated and Northern analysis confirmed a low expression of this cDNA at about 1,4 kb in MO which was increased by the addition of Vitamin D3. Using the rapid amplification of cDNA Ends (RACE)-PCR we got a transcript (DDVit 1) of a length of 1251 bp containing an open reading frame that encodes a putative 16,5 kD protein. Database search revealed an identity with a possible enterocyte differentiation promoting factor with a length of 1177 bp that has not been further characterized. Therefore DDVit 1 may be a differentiation promoting factor for the monocytic lineage. Further investigations will clarify the role of ...
1α,25-Dihydroxyvitamin D3 (1α,25(OH) 2D3) has antitumor activity in addition to its classical action on calcium metabolism and bone tissue biology. It is thought to regulate the expression of multiple target genes and thus modulate processes critical for tumor growth and metastases. Here we show that 1α,25(OH) 2D3 differentially regulates the expression of Id1 and Id2 genes, members of a family of transcriptional regulators of cell proliferation and differentiation. 1α,25(OH)2D3 induced epithelial differentiation in SW480-ADH human colon carcinoma cell line by promoting expression of the proteins implicated in adherent junction formation, including E-cadherin, and by inhibiting β-catenin transcriptional activity. 1α,25(OH)2D3 activated the human Id1 gene promoter and rapidly induced Id1 RNA and protein. Ectopic overexpression of Id1 was not sufficient to induce E-cadherin, which was critical for the morphological changes induced by 1α,25(OH)2D3 in SW480-ADH cells. Conversely, Id2 ...
There is evidence that the active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D), may lead to reduced tumor formation by inhibiting vascularization, and thus feeding the tumor (1). Vascularization is controlled in part by the release of proteins which can be stimulated by low oxygen (hypoxia) to increase the transcriptional activity of hypoxia inducible factor 1α (HIF-1α) (2). HIF-1α controls the level of an important protein, vascular endothelial growth factor (VEGF), which stimulates vascularization (2). The level of HIF-1α protein level is regulated both transcriptionally and by protein stability through the activity of prolyl hydroxylase (PHD) (2). The purpose of this study is to determine if 1,25(OH)2D alters the mRNA expression of HIF-1α in untransformed (normal) cells and cells that contain the ErbB2 oncogene, a mutated gene commonly found in cancers.
Sigma-Aldrich offers abstracts and full-text articles by [Steve Y Rhieu, Andrew J Annalora, Guochun Wang, Caroline C Flarakos, Rose M Gathungu, Paul Vouros, Rita Sigüeiro, Antonio Mouriño, Inge Schuster, G Tayhas R Palmore, G Satyanarayana Reddy].
TY - JOUR. T1 - The metabolism of 1,25-dihydroxyvitamin D3.. AU - Kumar, Rajiv. PY - 1980/6. Y1 - 1980/6. UR - http://www.scopus.com/inward/record.url?scp=0019030105&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019030105&partnerID=8YFLogxK. M3 - Article. C2 - 6894425. AN - SCOPUS:0019030105. VL - 1. SP - 258. EP - 267. JO - Endocrine Reviews. JF - Endocrine Reviews. SN - 0163-769X. IS - 3. ER - ...
Defective binding and function of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with end-organ resistance to 1,25-dihydroxyvita
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Kidney disease Therapies Dialysis Dialysis is primarily used to provide an artificial replacement for lost kidney function in people with renal failure. The death rate from cardiovascular disease for dialysis patients is much higher than the general population, regardless of age.vitamin D receptorVDRkidney diseaseVDRVDRkidney diseasevitamin D receptorvitamin D receptorVDRinflammationinflammationkidney diseasekidney disease1,25-dihydroxyvitamin D1,25-dihydroxyvitamin D1,25-dihydroxyvitamin Dse…
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Citation: Nelson, C.D., Beitz, D.C., Reinhardt, T.A., Lippolis, J.D. 2009. Expression of Inducible Nitric Oxide Synthase is Up-Regulated by Production of 1,25-Dihydroxyvitamin D3 in Bovine Monocytes in Response to Toll-Like Receptor Signaling [abstract]. American Dairy Science Association. Paper No. 84. Interpretive Summary: Technical Abstract: In the endocrine pathway of vitamin D signaling 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is produced from 25-hydroxyvitamin D3 [25(OH)D3] by the enzyme CYP27B1 in the kidney. Production of 1,25(OH)2D3 in the kidney functions to regulate gene expression systemically. However, recent studies have shown that human monocytes express CYP27B1 and produce 1,25(OH)2D3 in response to toll-like receptor recognition of bacterial cell wall components. Activation of 25(OH)D3 by CYP27B1 in human monocytes improves antimicrobial activity via an autocrine pathway. The purpose of this study was to determine if 1,25(OH)2D3 is produced by CYP27B1 in bovine monocytes upon TLR ...
1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D3 (25(OH)D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) broadened the ...
After doing some research, I have decided on adding/changing some vitamins to my daily regime to help with my migraines. • Riboflavin - 200 mg twice a day • Thiamine (vitamin B1) - 100 mg three ...