Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage, including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated. (A systemic mineral imbalance would elevate calcium levels in the blood and all tissues and cause metastatic calcification.) Basophilic calcium salt deposits aggregate, first in the mitochondria, and progressively throughout the cell. These calcifications are an indication of previous microscopic cell injury. It occurs in areas of cell necrosis in which activated phosphatases bind calcium ions to phospholipids in the membrane. Calcification can occur in dead or degenerated tissue. Caseous necrosis in T.B. is most common site of dystrophic calcification. Liquefactive necrosis in chronic abscesses may get calcified. Fat necrosis ...
Synonyms for dystrophic calcification in Free Thesaurus. Antonyms for dystrophic calcification. 8 words related to calcification: chemical action, chemical change, chemical process, ossification, hardening, inaction, inactiveness, inactivity. What are synonyms for dystrophic calcification?
Background Dystrophic calcifications may occur in patients with J uvenile Idiopathic Inflammatory Myopathy (JIIM) as well as other connective tissue and metabolic diseases, but a reliable method of measuring the volume of these calcifications has not been established. Myositis Assessment Scale (CMAS), myositis specific antibodies (MSA), and the TNF-308 promoter region A/G polymorphism. Statistical analysis utilized the Pearson correlation coefficient, the paired t-test and descriptive statistics. Results Ten JIIM, mean age 14.54??4.54?years, had a duration of untreated disease of 8.68??5.65 months? MSA status: U1RNP (1), PM-Scl (1), Ro (1, 4 indeterminate), p155/140 (2), MJ (3), Mi-2 indeterminate (1), negative (3). 4/8 JDM (50%) were TNF-308 A+. Overall, the calcification volumes tended to decrease from the first to the second CT study by 0.5?cm3 (from 2.79??1.98?cm3 to 2.29??2.25?cm3). The average effective radiation dose was 0.007??0.002, 0.010??0.005, and 0.245?mSv for the upper extremity, ...
TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. pathophysiology and management. Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy. Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
MalaCards based summary : Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23 ...
Mitral annular calcification (MAC) and aortic annular calcification (AVC) may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes. To examine the relationship between the degree of calcification at mitral and/or aortic valve annulus and large artery structure (thickness). We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP), pulse pressure (PP=SBP-DBP), body mass index (BMI), fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular/annular lesions independent scores based on acoustic densitometry: 1 = annular/valvular sclerosis/calcification absence; 2 = annular/valvular sclerosis; 3 = annular calcification; 4 =
In addition to fibrosis, calcification is a defining feature of aortic valve lesions. Calcification may contribute to lesion rigidity, thereby worsening obstruction to left ventricular outflow. Moreover, the extent of lesion calcification correlates both with more rapid disease progression and worse clinical outcomes.61,62. Aortic valve calcification now has been shown unequivocally to be an active, rather than a passive, process. Valvular calcium deposits contain both calcium and phosphate11,57,63,63 as hydroxyapatite,57,63 the form of calcium-phosphate mineral present in both calcified arterial tissue64 and bone. Proteins involved in regulation of tissue calcification have been detected in calcified valvular tissue, including osteopontin,13,14 bone morphogenic proteins (BMPs) 2 and 4,15 and receptor activator of nuclear factor NF-κB ligand (RANKL).65 Osteoprotegrin (OPG), which prevents mineral resorption in bone tissue, is a soluble decoy receptor that resembles RANK and acts as a ...
INTRODUCTION. Soft tissue radiopacities include calcification, ossification or foreign objects. The latter are excluded from this manuscript. Calcification is the deposition of calcium salts in tissue. The pathogenesis is based on either dystrophic or metastatic mechanisms. Dystrophic calcification, which comprises the majority of soft tissue calcifications in the head and neck region, is the result of soft tissue damage with tissue degeneration and necrosis which attracts the precipitation of calcium salts. The blood calcium concentration in these patients is normal. Appropriate examples are calcification of a focus of necrosis of tuberculosis, necrotic tumour tissue or of atheromatous plaque.. Metastatic calcification on the other hand results from the deposition of calcium salts in normal tissue in the presence of hypercalcemia secondary to metabolic causes such as hyperparathyroidism and skeletal deposits of malignant disease. Metastatic calcifications are therefore generally spread more ...
Looking for coronary artery calcification? Find out information about coronary artery calcification. Any process of soil formation in which the soil colloids are saturated to a high degree with exchangeable calcium, thus rendering them relatively immobile... Explanation of coronary artery calcification
Background and Aim: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT). Methods: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations. Results: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a radiologist
Cardiovascular calcification is prevalent in the aging population and in patients with chronic kidney disease (CKD) and diabetes mellitus, giving rise to substantial morbidity and mortality. Vitamin K-dependent matrix Gla-protein (MGP) is an important inhibitor of calcification. The aim of this study was to evaluate the impact of high-dose menaquinone-7 (MK-7) supplementation (100 µg/g diet) on the development of extraosseous calcification in a murine model. Calcification was induced by 5/6 nephrectomy combined with high phosphate diet in rats. Sham operated animals served as controls. Animals received high or low MK-7 diets for 12 weeks. We assessed vital parameters, serum chemistry, creatinine clearance, and cardiac function. CKD provoked increased aortic (1.3 fold; p < 0.05) and myocardial (2.4 fold; p < 0.05) calcification in line with increased alkaline phosphatase levels (2.2 fold; p < 0.01). MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline
Background: Clinical evidence links arterial calcification and cardiovascular risk. Fibrous cap microcalcifications can promote atherosclerotic plaque failure, and large calcifications can stabilize the plaque. Therefore, calcification morphology can determine cardiovascular morbidity, but temporal patterns of calcific mineral deposition and growth remain unknown.. Results: Apolipoprotein E-deficient (Apoe-/-) mice on an atherogenic diet develop plaque calcification. Longitudinal studies were performed using two different fluorescent calcium tracers injected intravenously into Apoe-/- mice: calcein injection following 18 weeks of atherogenic diet (n=7) and alizarin red S injection into the same mice 1 (n=4) or 3 (n=3) weeks later. Imaging green (calcein) and red (alizarin red S) fluorescence provided snapshots of aortic calcification at 18, 19, and 21 weeks. Observations within histological sections revealed green microcalcifications at 18 weeks embedded within alizarin red stained larger ...
Pathological calcification Definition: it is the deposition of calcium salts in sites other than bones and teeth. Grossly: the calcified tissue appears chalky white and hard. Microscopically, the calcification appears as blue granules (with haematoxylin and eosin stain). There are two types of pathological calcification: 1. Dystrophic calcification: it is the most common type. Definition: […]. Tags: calcification, Pathological, type, unknown. ...
Two brothers aged 10 years and 18 years presented with multiple soft tissue calcareous swellings around the elbows, arms, knees, and forearms, which had been present for the last three years. Both were in good general health and there was no history of trauma. On examination, the younger boy had a calcified soft tissue swelling around the left knee joint with a sinus around the medial side of the knee. There was occasional discharge of white chalky material from the sinus. Movements at the knee were full and there was no neurovascular problem. The other brother had calcareous, firm, soft tissue swellings over the right lower thigh, left and right arms, and around both the elbow joints. Movements at the elbow and knee joints were normal and he had no discharging sinus. Their serum calcium, serum phosphorus, alkaline phosphatase, and urinary calcium were within normal limits. The erythrocyte sedimentation rate and the leukocyte count were normal. A test for lupus erythematosus was negative and ...
Microcalcifications are small. They often occur because of benign (not cancer) changes, but occasionally microcalcifications can be an early sign of cancer.. Macrocalcifications are larger. They usually occur because of benign (not cancer) changes and do not need to be investigated.. Breast calcifications are very common. They are usually due to benign (not cancer) changes that occur as part of aging.. Sometimes they form because of other benign changes in the breast, such as a fibroadenoma or breast cyst. They can also form if youve had an infection in your breast, if youve injured your breast, or if youve had surgery or a breast implant.. Breast calcifications can develop in the blood vessels of the breast. These may be age-related or caused by other medical conditions but dont usually require further assessment.. Breast calcifications are more common in women, but can also be found in men.. Occasionally, breast calcifications can be an early sign of cancer. Because of this, you may need ...
To the best of our knowledge, the present IVUS study is the first to demonstrate the relationship between calcification patterns, arterial remodeling, and the morphology of plaques within the culprit lesion segment. The major finding is that there is a significant difference in the pattern of coronary calcifications at the culprit lesion segment, particularly with respect to size, number, and length of the deposits, among patients with AMI, UAP, and SAP. Small calcium deposits were significantly more frequent in the culprit lesion segments in ACS than in SAP patients. In fact, our qualitative analysis of calcifications demonstrated that the culprit segments of AMI patients were mostly characterized by small calcium deposits, associated with fibrofatty plaques and PR.. Thus far, there have been few quantitative IVUS studies of coronary plaque calcification in lesions associated with ACS. Nakamura et al8 recently reported that lesser degrees of calcium were observed in the culprit lesions of ACS ...
Intervention study focused on preventing the progression of aortic valve calcification. Vascular and cardiac calcifications are a marker of risk and po
TY - JOUR. T1 - Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the multi-ethnic study of atherosclerosis). AU - Cohen, Randy. AU - Budoff, Matthew. AU - McClelland, Robyn L.. AU - Sillau, Stefan. AU - Burke, Gregory. AU - Blaha, Michael. AU - Szklo, Moyses. AU - Uretsky, Seth. AU - Rozanski, Alan. AU - Shea, Steven. PY - 2014/10/15. Y1 - 2014/10/15. N2 - Although a coronary artery calcium (CAC) score of 0 is associated with a very low 10-year risk for cardiac events, this risk is nonzero. Subjects with a family history of coronary heart disease (CHD) has been associated with more subclinical atherosclerosis than subjects without a family history of CHD. The purpose of this study was to assess the significance of a family history for CHD in subjects with a CAC score of 0. The Multi-Ethnic Study of Atherosclerosis cohort includes 6,814 participants free of clinical cardiovascular disease (CVD) at baseline. Positive ...
Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, ...
2017, Springer Science+Business Media B.V., part of Springer Nature. Purpose: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients. Methods: Four hundred and nineteen patients were included. Lateral abdominal and pelvic radiographs were obtained. The degree of AAC and PAC was evaluated according to the methods described previously by Kaupplia et al. and Adragao et al. ...
Cardiovascular diseases represent the most common cause of global mortality (31%), affecting both developed and developing countries, claiming the lives of an estimated 17.5 million people in 2012 (1-3). Among the predictors for cardiovascular morbidity and mortality, cardiovascular calcification is an independent risk factor. Many pathologies, such as atherosclerosis, diabetes mellitus, and chronic kidney disease, are often associated with cardiovascular calcification (4, 5), which can occur in blood vessels, the myocardium, and cardiac valves. In blood vessels, calcification typically occurs in intimal atherosclerotic plaques and in the tunica media (4, 6-8).. In the past two decades, research has highlighted the active inflammatory and/or osteogenic signaling processes that contribute to pathological cardiovascular calcification, shifting the paradigm away from that of a passive accumulation of minerals (9, 10). However, very little is known about the mechanism of nonpathological mineral ...
In a study to ascertain whether breast arterial calcification (BAC) detected with digital mammography correlates to chest CT findings of coronary artery calcification (CAC), researchers have discovered a striking relationship between the two factors. In 76 percent of the study cohort, women who had a BAC score of 0 also had a CAC score of 0. As the BAC score increases, there is a concomitant increase in the CAC score.
Background: Recent guidelines have suggested that presence of coronary artery calcium (CAC) is an independent marker of adverse cardiovascular disease (CVD) events and mortality. However the predictive value of thoracic aorta calcification (TAC) that can be additionally identified without further scanning during assessment of CAC is unknown.. Method: We followed a cohort of 8418 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and coronary calcium testing with electron-beam CT for median period of 5.0 years. Multivariable Cox proportional hazards models were developed to predict all-cause mortality obtained from the National Death Index with presence of TAC.. Results: 141 (2%) all cause deaths were recorded. Overall survival was 96.7% and 98.8% for subjects with and without detectable TAC (p , 0.0001). As compared to those with absent TAC (reference group) the hazard ratio for mortality for subjects with TAC was 3.07 (95% CI: 2.20 - 4.38) in ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
Is this going to be okay? From what I understand, lots of babies can have this and turn out absolutely normal. The doctor told me everything was measuring properly and that the baby was actually measuring in at 20 weeks but that there were two calcium deposits in the heart? Calcium Deposit In The Fetus S Heart. The fetal heart rate (FHR) is usually faster as compared to the heart rate of an adult. First, I have a placenta previa (the doctor says there is a good chance this will change before delivery) and the second is a calcium deposit in the babys heart, which my doc says could be a sign of Downs Syndrome. Calcifications were mainly located in the liver (57%), but also in heart (13%), bowel (6%) and other tissues. The cause of EIF is unknown, but the condition is generally harmless. So this morning we had our 20 week ultrasound. for the most part is measuring good and most is fine. Q: Tests showed that the baby has calcium deposits in the heart at 20 weeks. Echogenic intracardiac focus (EIF) ...
This 15 year longitudinal study provides insights into the relationship between coronary artery calcification and diabetes mellitus. Abstract Background Data regarding coronary artery calcification (CAC) prognosis in diabetic individuals are limited to 5-years follow-up. We investigated the long-term risk stratification of CAC among diabetic compared with nondiabetic individuals. Methods and Results Nine thousand seven…
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In a previous study ([17]) performed in the same patient group as that in the present study, the total coronary calcification score predicted coronary stenosis. The sensitivity, specificity, PPV, NPV and accuracy of the total calcification score were 0.77, 0.86, 0.86, 0.76 and 0.81, respectively. The sensitivity (0.75), specificity (0.81) and accuracy (0.80) of calcification for prediction of significant stenosis was similar in the present study, but the PPV (0.36) was significantly lower (p , 0.0001 by chi-square analysis) and the NPV (0.96) significantly higher (p , 0.0001). These differences were revealed by the site by site comparison. As in our previous study ([17]), the prevalence and amount of coronary calcification increased with age, even in patients without significant stenosis. These findings may explain why the PPV and sensitivity increased significantly with age for all atherosclerotic lesions. The PPV and sensitivity did not increase with age for significant stenosis. Although the ...
CALCINOSIS CUTIS TREATMENT PDF - BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but theres still no consensus on treatment. OBJECTIVES.
TY - JOUR. T1 - Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people. T2 - The Cardiovascular Health Study. AU - Massera, Daniele. AU - Xu, Shuo. AU - Bartz, Traci M.. AU - Bortnick, Anna E.. AU - Ix, Joachim H.. AU - Chonchol, Michel. AU - Owens, David S.. AU - Barasch, Eddy. AU - Gardin, Julius M.. AU - Gottdiener, John S.. AU - Robbins, John A. AU - Siscovick, David S.. AU - Kizer, Jorge R.. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Summary: Associations between bone mineral density and aortic valvular, aortic annular, and mitral annular calcification were investigated in a cross-sectional analysis of a population-based cohort of 1497 older adults. Although there was no association between continuous bone mineral density and outcomes, a significant association between osteoporosis and aortic valvular calcification in men was found. Introduction: The process of cardiac calcification bears a resemblance to skeletal bone metabolism and its ...
The present study examined the diagnostic performance of FFRCT at various levels of coronary calcification for the identification and exclusion of ischemia-causing lesions using FFR as the reference standard. The 2 major findings of this study were: 1) FFRCT provided high per-patient and per-vessel diagnostic performance and discrimination for ischemia over a wide range of coronary calcification severity; and 2) the diagnostic performance of FFRCT was superior to coronary CTA stenosis interpretation regardless of the AS level.. Because the presence of myocardial ischemia is associated with a poor prognosis (23), current guidelines recommend noninvasive functional imaging testing as the first-line strategy in patients with suspected stable CAD (21). However, shortcomings of current noninvasive diagnostic strategies are apparent from the frequent inaccurate selection of patients for ICA (24,25). To date, FFR is the only diagnostic tool shown to improve clinical outcomes and to reduce health care ...
Idiopathic Infantile Arterial Calcification (IIAC) also known as Arterial Calcification of Infancy, Generalised Infantile Arterial Calcification (GACI), Idiopathic Arterial Calcification of Infancy (IACI), Occlusive Infantile Arterial Calcification, Occlusive Infantile Arteriopathy is an extremely rare, usually fatal genetic disorder, caused by mutations in the ENPP1 gene in 75% of the subjects. The condition affects infants during the first 6 months of life. This condition is inherited as an autosomal recessive pattern. It is characterized by generalised calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. Most infants die of vaso-occlusive disease, especially of the coronary arteries. Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero. Decreased fetal activity Gestation with an ...
DESIGN: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatstons method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors ...
A database of 145 mammograms containing biopsy proven malignant or benign microcalcifications was digitized with a laser scanner at a pixel size of 35 micrometer by 35 micrometers. Digitization at larger pixel sizes was simulated by averaging adjacent pixels. The individual microcalcifications were segmented from the digital images with region growing and adaptive gray level thresholding techniques. The characteristics of the individual microcalcifications were analyzed with visibility descriptors and shape descriptors. The variations of visibility and shape of the microcalcifications in a cluster were evaluated by the standard deviation, the coefficient of variation, and the maximum of each of the descriptors. In addition, texture features were extracted from the spatial gray level dependence (SGLD) matrices in the region containing the cluster of microcalcifications. A genetic algorithm (GA) was used to select features from the multidimensional morphological and texture feature space. Linear ...
Comments, concepts and statistics about Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study.
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Vascular and valvular calcification are commonly encountered in clinical medicine and a greater understanding of their significance and pathophysiology remain a subject of immense importance. In the coronary arteries, vascular calcification burden correlates with the severity of luminal stenosis and atherosclerotic plaque burden. While in progressive lesions, the presence of coronary calcification is not binary but rather depends on the type of calcification. Racial and gender differences, and comorbidities like diabetes mellitus and chronic kidney disease, all affect the presence and severity of calcification. The peripheral arteries of the lower extremities are affected by both medial calcification and intimal calcification, and the former barely contributes to luminal stenosis. The character of atherosclerosis differs between above-knee and below-knee lesions. Valvular calcification generally occurs on the aortic valve leaflets, and pathologic findings range from minimal fibrocalcific changes in
As a new feature of CNNhealth.com, our team of expert doctors will answer readers questions. Heres a question for Dr. Gupta. Asked by Collin, Oak Park, Illinois Im in my 40s and was told I have cardiac calcification.
As a new feature of CNNhealth.com, our team of expert doctors will answer readers questions. Heres a question for Dr. Gupta. Asked by Collin, Oak Park, Illinois Im in my 40s and was told I have cardiac calcification.
Materials and Methods: A retrospective study of seven patients of tumoral calcinosis treated with complete surgical excision over a period of 1 year was done. Demographic details were compiled. Routine blood investigations were performed. All patients underwent radiographs and magnetic resonance imaging (MRI) scans of involved part. We did not perform computed tomography (CT) or bone scan in any of our patients. All seven patients underwent surgery and were followed up till 2 years ...
Aortic valve calcification (AVC) without outflow obstruction (stenosis) is common in the elderly and increases the risk of cardiovascular morbidity and mortality. Although high blood pressure (BP) measured at the doctors office is known to be associated with AVC, little is known about the association between 24-hour ambulatory BP (ABP) and AVC. Our objective was to clarify the association between ABP variables and AVC. The study population consisted of 737 patients (mean age, 71±9 years) participating in the Cardiovascular Abnormalities and Brain Lesions study who underwent 24-hour ABP monitoring. Each aortic valve leaflet was graded on a scale of 0 (normal) to 3 (severe calcification). A total valve score (values 0-9) was calculated as the sum of all leaflet scores. Advanced AVC (score ≥4) was present in 77 subjects (10.4%). All of the systolic ABP variables (except systolic BP nocturnal decline) and mean asleep diastolic BP were positively associated with advanced calcification, whereas normal
Background: Recent studies showed that the assessment of aortic valve calcification (AVC) by multidetector computed tomography (MDCT) is useful to corroborate hemodynamic severity of aortic stenosis (AS). AVC load might provide incremental value beyond clinical and echocardiographic parameters of AS severity to predict hemodynamic progression and occurrence of valve-related events.. Methods: Three hundred twenty three patients (68±13 yrs, 70% men) with AS were prospectively enrolled in 2 academic centers. Hemodynamic AS progression was assessed by annualized increase in mean gradient (MG) measured by echocardiography. AVC was measured by MDCT using the Agatston method and was indexed to the cross-sectional area of the aortic annulus to obtain AVC density (AVCd).. Results: Patients with rapid progression (MG progression ≥3.0 mmHg/yr, median for the cohort) had higher AVCd at baseline as compared to those with slow progression (median [IQR]: AVCd: 322 [160-508] vs 175 [84-309] AU/cm2; ...
Looking for online definition of apocrine cystic calcinosis in the Medical Dictionary? apocrine cystic calcinosis explanation free. What is apocrine cystic calcinosis? Meaning of apocrine cystic calcinosis medical term. What does apocrine cystic calcinosis mean?
The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition. ...
Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. However, no mutations in FGF23, KL, or FGF receptor 1 (FGFR1) were identified. He subsequently developed type 1 diabetes mellitus, which raised the possibility of an autoimmune cause for hyperphosphatemic tumoral calcinosis. Luciferase immunoprecipitation systems revealed markedly elevated ...
Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating mutations in FGF23, N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO (KL) have been reported as causing HFTC/HHS. We present what we believe is the first identified case of autoimmune hyperphosphatemic tumoral calcinosis in an 8-year-old boy. In addition to the classical clinical and biochemical features of hyperphosphatemic tumoral calcinosis, the patient exhibited markedly elevated intact and C-terminal FGF23 levels, suggestive of FGF23 resistance. However, no mutations in FGF23, KL, or FGF receptor 1 (FGFR1) were identified. He subsequently developed type 1 diabetes mellitus, which raised the possibility of an autoimmune cause for hyperphosphatemic tumoral calcinosis. Luciferase immunoprecipitation systems revealed markedly elevated ...
BACKGROUND: Peripheral arterial disease and vascular calcifications contribute significantly to the outcome of dialysis patients. The aim of this study was to evaluate the prognostic role of severity of abdominal aortic calcifications and peripheral arterial disease on outcome of peritoneal dialysis (PD) patients using methods easily available in everyday clinical practice.. METHODS: We enrolled 249 PD patients (mean age 61 years, 67% male) in this prospective, observational, multicenter study from 2009 to 2013. The abdominal aortic calcification score (AACS) was assessed using lateral lumbar X ray, and the ankle-brachial index (ABI) using a Doppler device.. RESULTS: The median AACS was 11 (range 0 - 24). In 58% of the patients, all 4 segments of the abdominal aorta showed deposits, while 19% of patients had no visible deposits (AACS 0). Ankle-brachial index was normal in 49%, low (, 0.9) in 17%, and high (, 1.3) in 34% of patients. Altogether 91 patients (37%) died during the median follow-up ...
Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction
What follows is a listing of factors that are active at different points of the proposed mechanisms of calcification. At present it is impossible to outline the most important ones.. Periostin is found in VICs from healthy bovine aortic valves, but expression increases following exposure to LPS. Periostin is chiefly expressed in VICs of the lamina ventricularis, less in the fibrosa, and is coexpressed with elastin.57 Periostin is secreted by macrophages and myofibroblasts, and it stimulates expression of MMP‐2 and ‐9 in human VICs. Wild‐type mice fed with the Western diet develop aortic stenosis, but periostin‐knockout mice do not. In addition, they express lower levels of αSMA, collagen 1, and MMP‐2 and ‐13.57 Periostin may thus play a stimulatory role in the development of valve calcification.. Jian and colleagues showed that whereas healthy aortic valves did not express MMP‐2 or ALP, diseased valves expressed both, as well as tenascin‐C, an extracellular matrix glycoprotein ...
TY - JOUR. T1 - Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. AU - Prenner, Stuart B.. AU - Mulvey, Claire K.. AU - Ferguson, Jane F.. AU - Rickels, Michael R.. AU - Bhatt, Anish B.. AU - Reilly, Muredach P.. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Objective: While recent genomic studies have focused attention on triglyceride (TG) rich lipoproteins in cardiovascular disease (CVD), little is known of very low-density lipoprotein cholesterol (VLDL-C) relationship with atherosclerosis and CVD. We examined, in a high-risk type-2 diabetic population, the association of plasma VLDL-C with coronary artery calcification (CAC). Methods: The Penn Diabetes Heart Study (PDHS) is a cross-sectional study of CVD risk factors in type-2 diabetics (n = 2118, mean age 59.1 years, 36.5% female, 34.1% Black). Plasma lipids including VLDL-C were calculated (n = 1879) after ultracentrifugation. Results: In Tobit ...
Vascular calcification is prevalent in diabetes mellitus and is correlated with adverse cardiovascular outcome32,33; however, the molecular mechanisms underlying increased vascular calcification in diabetes mellitus are largely unknown. Elevation of O-GlcNAcylation is found in human diabetic carotid plaques20 and diabetic mouse vasculature.34 Coincidently, increased vascular calcification has been identified in patients with both type I and type II diabetes mellitus35 and diabetic mouse models.6 Nevertheless, the role of O-GlcNAcylation in vascular calcification has not been previously determined. The present study has demonstrated a causative effect of O-GlcNAcylation on diabetic vascular calcification. Our studies revealed that the activation of AKT by O-GlcNAcylation in vasculature is a key to diabetic vascular calcification. Two novel O-GlcNAcylation sites on AKT play a crucial role in enhancing AKT phosphorylation at S473 to increase vascular calcification. Because O-GlcNAcylation is ...
Radiographic findings in the extremities include acroosteolysis, soft tissue calcifications (calcinosis), and atrophy of the distal finger tips. Compared with hand involvement in scleroderma, foot involvement has a later onset and is relatively less frequent but can be disabling. Soft tissue changes included flexion deformities, generalized or localized atrophy, and dystrophic calcifications. In a study by Bassett et al.[1], resorption of distal phalanges was the most common bony change in patients with scleroderma, though osteolysis in other sites (feet, ribs, and mandibles) was also frequent. Nearly 20% showed radiographic evidence of inflammatory arthritis and joint destruction that could not be attributed to overlap with rheumatoid arthritis or mixed connective tissue disease.. Radiographic findings of other organ systems include fibrosis in the lungs and abnormal esophogram related to dysmotility.. File:Scleroderma.jpg. ...
Looking for online definition of arterial calcification, generalised, of infancy type 2 in the Medical Dictionary? arterial calcification, generalised, of infancy type 2 explanation free. What is arterial calcification, generalised, of infancy type 2? Meaning of arterial calcification, generalised, of infancy type 2 medical term. What does arterial calcification, generalised, of infancy type 2 mean?
Involvement of the basal ganglia in AIDS encephalopathy is well documented in both adults and children. The pathology remains obscure. A type of inflammation with increased vascularity and disruption of the blood-brain barrier has been postulated. Calcification of the basal ganglia in encephalopathic HIV / AIDS children has been relatively well documented. Only two adult HIV cases with basal ganglion calcification (BGC) have been reported in the literature. At our institution over the past few years, we have noted an increasing number of adult AIDS patients with neurological complications, demonstrating BGC on CT examination. A retrospective review was done. Ninety-six adult cases were identified with BGC. Of these, 38 patients were HIV positive. Review of the 38 HIV-positive cases revealed that all of the patients presented clinically with encephalopathic symptoms, and all showed BGC associated with varying degrees of atrophy on CT scan. Reports of paediatric HIV cases with BGC and encephalopathy have
Mean follow-up was 3.1 ± 2.6 years, with 440 AVRs and 194 deaths. High AVC density was associated with increased aortic valve peak velocity, higher mean gradient, and decreased valve area (p < 0.001 for each). Severe versus nonsevere AVC was associated with reduced 5-year survival in those treated medically (41 ± 6% vs. 78 ± 6%, p < 0.001). On multivariate analysis, severe AVC (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.04-2.92; p = 0.03) and severe AVC density (HR, 2.44; 95% CI, 1.37-4.37; p = 0.002) were independently associated with increased mortality in patients treated medically. For survival regardless of AVR, both severe AVC (HR, 1.71; 95% CI, 1.12-2.62; p = 0.01) and severe AVC density (HR, 2.22; 95% CI, 1.37-4.37; p = 0.002) remained associated with increased mortality; both of these variables remained statistically significant when adjusted for coronary artery calcium score in the subset with this available (p < 0.05 for each). Multivariable analysis observed that ...
Relief is when you and the right researcher find each other Finding the right clinical trial for Basal ganglia calcification, idiopathic, 3 can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
In this issue of iJACC, Silverman et al. (1) report the relationship of baseline Agatston coronary artery calcium (CAC) score and coronary calcium distribution with future incident coronary revascularization in 6,540 MESA (Multi-Ethnic Study of Atherosclerosis) participants. The primary findings of this novel analysis is that baseline calcium score and the number of vessels with CAC were each independently predictive of future coronary revascularizations over a median follow-up of 8.5 years. Additionally, among subjects who underwent revascularization, those with more diffuse baseline CAC were at higher risk to undergo coronary artery bypass graft (CABG) versus percutaneous coronary intervention (PCI). Specifically, adjusted for overall CAC score, individuals with 3- and 4-vessel CAC were 3 to 4 times more likely to undergo coronary revascularization than were patients with CAC in a single vessel, and ≥3 vessel CAC was strongly predictive of the risk for future CABG, particularly when ...
Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs.. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand.. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma.. Increasing of therapy with phosphate binders and cinacalcet only, was not effective to solve cutaneous masses, that were biopsied. Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis.. We further increased dialysis and therapy and we observed complete regression of masses in 2 months.. Key words: dystrophic ...
THESIS:. Objective: assess the prevalence of thoracic aortic calcification and aneurysm in patients in lung cancer screening.. Materials and methods: the retrospective study included randomly selected results of ultra-low-dose computed tomography of 254 patients.. Results: quantitative analysis of aortic calcination by Agatston, Volume, Mass index, as well as qualitative and quantitative analysis of aortic aneurysm occurrence in lung cancer screening was performed.. Conclusion: it is necessary to pay attention to the presence of thoracic aorta calcification and aneurysm in lung cancer screening, as these changes are closely associated with a high risk of cardiovascular diseases leading to death.. KEYWORDS: Aortic calcification, Aortic aneurysm, Ultra-low-dose computed tomography.. CORRESPONDING AUTHOR: Korkunova O. A. E-MAIL: [email protected] FOR CITATIONS: Korkunova O. A., Suchilova M. M., Nikolayev A. E., Grishkov S. M., Gombolevskiy V. А., Bosin V. Yu. - Aortic calcification and ...
Korean researchers have recently shown that drinking coffee is linked to lower arterial calcification (calcium deposits in vascular walls). Arterial calcification predicts increased cardiovascular risk, independent of the usual cardiovascular risk factors, and so its very important to prevent it.. The link between coffee consumption and prevalence of coronary artery calcium (CAC) was examined in 25 138 men and women (mean age 41.3 years). The subjects had no clinically evident cardiovascular disease, and CAC scores were determined by computed tomography. CT scans showed that 13.4% of subjects had detectable coronary artery calcium. The mean coffee consumption was 1.8 cups per day.. The study showed that coffee drinkers had lower coronary artery calcium scores, as compared to noncoffee drinkers. Those that drank 3 or 4 cups per day had the lowest coronary artery calcium scores. This link was similar inmen and women and for subgroups defined by age, weight, smoking status, alcohol consumption, ...
High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS) and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years) who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG) after drug-eluting stent (DES) were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG). The CCSs for predicting stent revascularization were elucidated. Results:
Vascular calcification refers to the abnormal deposition of calcium phosphate salts in blood vessels, myocardium, and cardiac valves. Vascular calcification can be life-threatening, as in the case of generalized infantile arterial calcification, calcific uremic arteriolopathy, and calcific valve disease.1,2 In atherosclerotic lesions, calcification is mainly found in the intima of blood vessels as dispersed punctate or patchy crystals associated with the necrotic core of atheromas (intimal calcification) and has been shown to positively correlate to the atherosclerotic plaque burden and the increased risk of myocardial infarction.3 Calcium phosphate salts deposit also in the media of blood vessels, known as Monckebergs medial sclerosis (medial calcification), and is prevalent in aging and patients with chronic kidney disease and type 2 diabetes mellitus.2,4,5 Medial calcification in these patients can occur independently of intimal calcification and/or atherosclerotic lesions and features ...
Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and mesenchymal transition of endothelial cells (EndMT). In this study, we investigated the contribution of BMP signal transduction to the medial calcification that develops in MGP-deficient mice. Approach and Results MGP-deficient mice (MGP-/-) were treated with one of two BMP signaling inhibitors, LDN-193189 or ALK3-Fc, beginning one day after birth. Aortic calcification was assessed in 28-day-old mice by measuring the uptake of a fluorescent bisphosphonate probe and by staining tissue sections with Alizarin red. Aortic calcification was 80% less in MGP-/- mice treated with LDN-193189 or ALK3-Fc compared with vehicle-treated control animals (P,0.001 for both). LDN-193189-treated MGP-/- mice survived ...
Definition of Physiological intracranial calcification with photos and pictures, translations, sample usage, and additional links for more information.
TY - JOUR. T1 - Ethnic Differences in the Prognostic Value of Coronary Artery Calcification for All-Cause Mortality. AU - Nasir, Khurram. AU - Shaw, Leslee J.. AU - Liu, Sandy T.. AU - Weinstein, Steven R.. AU - Mosler, Tristen R.. AU - Flores, Phillip R.. AU - Flores, Ferdinand R.. AU - Raggi, Paolo. AU - Berman, Daniel S.. AU - Blumenthal, Roger S.. AU - Budoff, Matthew J.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/9/4. Y1 - 2007/9/4. N2 - Objectives: The purpose of this study was to evaluate the prognostic value of coronary artery calcium (CAC), a known marker of subclinical atherosclerosis, in a large, ethnically diverse cohort of 14,812 patients for the prediction of all-cause mortality. Background: Disparities in case fatality rates for heart disease among ethnic groups are well known. In 2001, rates of death from heart disease were 30% higher among African Americans (AA) than non-Hispanic whites (NHW). Some of this variability may be due to differing ...
Aortic calcification was demonstrated in experimental animal models of hyperhomocysteinemia. Mild hyperhomocysteinemia was associated with aortic calcification, suggesting a relationship between homocysteine (HCY) and the pathogenesis of aortic calcification. In the present study, the effect of HCY on vascular calcification was examined in calcifying and non-calcifying vascular smooth muscle cells (VSMCs). Cell calcification was induced by incubation of VSMCs with [ glycerophosphate. Proliferation of VSMCs was studied by cell counting, H-3-thymidine (H-3-TdR) and H-3-leucine (H-3-Leu) incorporation. Ca-45 accumulation, cell calcium content, and alkaline phosphatase (ALP) activity were measured as indices of calcification. The results showed that the proliferation of calcifying VSMCs, which was indicated by cell counting, H-3-TdR and H-3-Leu incorporation in calcifying VSMCs, was enhanced as compared with that of non-calcifying VSMCs. HCY promoted increases in cell number, H-3-TdR and H-3-Leu ...
Association of serum phosphorus, calcium and parathyroid hormone with cardiovascular calcification in regular hemodialysis patients
Cardiovascular Calcification And Bone Mineralization è un libro di Aikawa Elena (Curatore), Hutcheson Joshua D. (Curatore) edito da Humana a luglio 2021 - EAN 9783030467272: puoi acquistarlo sul sito HOEPLI.it, la grande libreria online.
Sigma-Aldrich offers abstracts and full-text articles by [R Vongpromek, S Bos, G-J R Ten Kate, R Yahya, A J M Verhoeven, P J de Feyter, F Kronenberg, J E Roeters van Lennep, E J G Sijbrands, M T Mulder].
Contrary to the general assumption, we found that PPi has bioavailability in humans and mice when administered orally (Fig 1). The observed transient elevation found in healthy volunteers (Fig 1A) indicates that in both GACI and in PXE patients, PPi levels may be transiently raised to the physiological level when 67 or 98 mg Na4PPi/kg of body weight is taken. Importantly, it has been shown that inhibition of calcification in uremic rats and in PXE mice can be achieved by daily intraperitoneal injections of PPi triggering transient increase in plasma PPi levels (ONeill et al, 2011; Pomozi et al, 2017). We determined a t1/2 = 44.7 min what is rather similar to that published in rat (34.1 min; ONeill et al, 2011).. We also demonstrated significant attenuation of calcification in two different well‐characterized mouse models of ectopic calcification disorders, PXE and GACI when the animals were treated with pyrophosphate orally. Furthermore, we demonstrated PPi uptake from the oral cavity and ...
The geminal bisphosphonates are a new class of drugs characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate, but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical effect leads in vivo to the prevention of soft tissue calcification and, in some instances, inhibition of normal calcification. The main effect is to inhibit bone resorption, but in contrast to the effect on mineralisation, the mechanism involved is cellular. These various effects vary greatly according to the structure of the individual bisphosphonate. The half-life of circulating bisphosphonates is very brief, in the order of minutes to hours. 20% to 50% of a given dose is taken up by the skeleton, the rest being excreted in the urine. The half-life in bone is far longer and depends upon the turnover rate of the skeleton itself. Bisphosphonates are very well tolerated; the ...
Normophosphataemic familial tumoral calcinosis, charac-terized by ectopic mineralization of skin, is caused by mutations in the SAMD9 gene located in human chromosome 7q21, next to a paralogous gene, SAMD9-like (SAMD9L). The mouse does not have a SAMD9 orthologue, Samd9, because it has been deleted during evolution owing to genomic rearrangements. It has been suggested that the mouse Samd9l gene serves as a functional paralogue of human SAMD9. In this study, we examined Samd9l knockout mice with respect to ectopic mineralization. We also crossed these mice with Abcc6(tm1JfK) mice, a model system to study pseudoxanthoma elasticum, to see whether the absence of the Samd9l gene modifies the mineralization process. Necropsy analysis of Samd9l(tm1Homy) mice revealed no evidence of ectopic mineralization, and deletion of the Samd9l gene in mice failed to modify the mineralization process on the Abcc6(tm1JfK) background. Collectively, the results suggest that mouse Samd9l is not a functional paralogue of human
Read also: Study: Salt intake accelerates kidney scarring in CKD patients by activating brain-kidney connection. Blood vessel calcification may put people who develop recurrent kidney stones at increased risk of heart disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that monitoring such calcification may help protect stone formers heart health.. About 10% of men and 7% of women develop kidney stones. Over the last decade, large epidemiological studies have shown that kidney stone formers have an increased likelihood of developing other conditions such as hypertension, chronic kidney disease and heart disease; however, the mechanisms involved are unknown.. Linda Shavit, MD, from the University College London Medical School, in the UK, and Shaare Zedek Medical Center, in Israel, and her colleagues wondered whether the heart problems experienced by kidney stone formers might be due to abnormal ...
Tendon calcification in the shoulder joint. X-ray of a shoulder joint showing acute calcification in the subscapularis tendon. The bone on the left is the humerus, the rounded head of which articulates with the scapula on the right. The calcification is the small white area at the base of the articulation of these two bones. Calcification may occur due to damage to the tendon, and can make movement of the joint very painful and stiff (rheumatism). Treatment is by local corticosteroid injection which reduces inflammation, ultrasound application to disrupt the calcium deposit or, occasionally, surgical removal of the deposit. - Stock Image M110/0347
Medial vascular calcification (MVC) is a pathological condition common to a variety of diseases, including chronic kidney disease, diabetes, obesity, generalized arterial calcification of infancy, arterial calcification due to deficiency of CD73, and Keutel syndrome. These diseases share the common feature of tissue-nonspecific alkaline phosphatase (TNAP) upregulation in the vasculature. We developed a mouse model that overexpresses human TNAP in vascular smooth muscle cells, in an X-linked manner. As early as 7 days of age, mice showed strong TNAP expression in the aorta and, by 14 days, distinct aortic calcification was visible by X-ray. Hemizygous overexpressor male mice (TaglnCre/WT; HprtALPLflox/Y) exhibit severe cardiac hypertrophy and have a median age of death of 44 days, whereas the hypertrophy is less pronounced and life expectancy is normal in heterozygous females (TaglnCre/WT; HprtALPLflox/WT). Gene expression analysis showed upregulation of classical markers of MVC (Bmp2, Mgp and ...
Calciphylaxis is a rare and devastating disease, affecting mostly patients with end-stage kidney disease, but also affecting patients with preserved kidney function. Due to the low prevalence of the disease, high quality evidence for the evaluation and management of calciphylaxis is lacking. Most of the current evidence and recommendations are based on small studies, case reports, and expert opinion. In an article published in the July issue of AJKD, Nigwekar et al thoroughly review the current literature on calciphylaxis and provide a summary of recommendations to evaluate and manage patients with calciphylaxis, developed by the Massachusetts General Hospitals Multi-Disciplinary Calciphylaxis Team.. Clinically, calciphylaxis presents with severe painful skin lesions that are frequently complicated by blistering and ulcerations. Histologically, it is characterized by vascular and soft tissue calcification, intimal hypertrophy, and microthrombosis of small vessels, which result in necrotizing, ...
Between 1995 and 1997 our laboratory made a diagnosis of MAC by transthoracic echocardiography in 805 patients. Of these, 133 (73 women and 60 men; age range, 47 to 89 years; mean, 74.3±8 years) underwent carotid artery duplex ultrasound for various indications. This group was compared with 129 age- and sex-matched patients (72 women and 57 men; age range, 61 to 96 years; mean, 73.6±7 years) without MAC who underwent carotid artery duplex ultrasound during the same period. Patients with rheumatic valvular disease, cardiomyopathy, or prosthetic valves were excluded.. Complete 2-dimensional and Doppler color flow examinations were performed in all patients with the 2.5-MHz transducer of a Hewlett-Packard phased array sector scanner (model 77020 A). The 2-dimensional echocardiographic criteria for MAC included an intense echo-producing structure located at the junction of the atrioventricular groove and posterior mitral valve leaflet on the parasternal long axis and apical 4-chamber views or an ...
OBJECTIVE: To investigate the association between regular coffee consumption and the prevalence of coronary artery calcium (CAC) in a large sample of young and middle-aged asymptomatic men and women. METHODS: This cross-sectional study included 25 138 men and women (mean age 41.3 years) without clinically evident cardiovascular disease who underwent a health screening examination that included a validated food frequency questionnaire and a multidetector CT to determine CAC scores. We used robust Tobit regression analyses to estimate the CAC score ratios associated with different levels of coffee consumption compared with no coffee consumption and adjusted for potential confounders. RESULTS: The prevalence of detectable CAC (CAC score >0) was 13.4% (n=3364), including 11.3% prevalence for CAC scores 1-100 (n=2832), and 2.1% prevalence for CAC scores >100 (n=532). The mean +/-SD consumption of coffee was 1.8+/-1.5 cups/day. The multivariate-adjusted CAC score ratios (95% CIs) comparing coffee ...
Hamuro, Y, Acute changes in inorganic phosphorus, urea, and alkaline phosphatase of plasma and glomerular filtration rate during the development of soft tissue calcification in the kk mice fed a diet low in magnesium and high in phosphorus. (1971). Subject Strain Bibliography 1971. 269 ...
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5 triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3,5-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity ...
Two siblings with idiopathic infantile arterial calcification are reported. The fetal and postnatal echocardiographic features were a large pericardial effusion, thickened pulmonary and aortic valves, poor pulsation of the descending aorta, and calcification of the great vessels. In one patient calcification was first detected at 33 weeks gestation. Despite treatment with disodium etidronate both children died. ...
Calcium deposits in veins - What are calcium deposits in the urine? Sometimes the level. Of calcium in the urine or blood is so high that it precipitates and forms deposits in the kidney called nephrocalcinosis. The is related to, but not the same as kidney stones. It can be caused by several genetic syndromes, hyperparathyroidism and vitamin D toxicity, certain meds, TB, renal tubular acidosis, etc. It is usually managed by treated the underlying condition. Good wishes:)
Pseudoxanthoma elasticum (PXE) is a genetic disease considered as a paradigm of ectopic mineralization disorders, being characterized by multisystem clinical manifestations due to progressive calcification of skin, eyes, and the cardiovascular system, resembling an age-related phenotype. Although fibroblasts do not express the pathogenic ABCC6 gene, nevertheless these cells are still under investigation because they regulate connective tissue homeostasis, generating the arena where cells and extracellular matrix components can promote pathologic calcification and where activation of pro-osteogenic factors can be associated to pathways involving mitochondrial metabolism. The aim of the present study was to integrate structural and bioenergenetic features to deeply investigate mitochondria from control and from PXE fibroblasts cultured in standard conditions and to explore the role of mitochondria in the development of the PXE fibroblasts pathologic phenotype. Proteomic, biochemical, and ...
So far, despite the large list of widely known risk factors, in daily practice, there is a reduced list of modifiable factors that can be controlled adequately in patients with CKD. The final part of this article reviews some aspects that are related to possible interventions to reduce vascular calcifications. Some of them are available already, and others still are in the experimental area.. Because of the high prevalence of hyperphosphatemia in patients with CKD stage 5 (still approximately 40 to 70% in most large series) and the implications of high phosphate in vascular events and mortality and its implications in the pathogenesis of secondary hyperparathyroidism, most strategies have concentrated on the control of serum phosphorus. Despite great efforts, still poor results have been obtained to bring serum phosphorus to safe values in the majority of dialysis patients. In addition, few studies have demonstrated the benefits of reducing serum phosphorus on vascular calcifications and ...
The invention provides a standard component for calibration that enables a calibration position to be easily specified in order to calibrate accurately a scale factor in the electron-beam system, and provides an electron-beam system using it. High-accuracy metrology calibration capable of specifying a calibration position can be realized by forming a mark pattern or labeled material for identifying the calibration position in proximity of a superlattice pattern of the standard component for system calibration. The standard component for calibration is one that calibrates a scale factor of an electron-beam system based on a signal of secondary charged particles detected by irradiation of a primary electron beam emitted from the electron-beam system on a substrate having a cross section of a superlattice of a multi-layer structure in which different materials are deposited alternately. The substrate have linear patterns that are on the substrate surface parallel to the multi-layer and are arranged at a
Our findings indicate that neutrophil counts and (re)activity are not directly associated with silent CAD disease burden and as such are not suitable as biomarkers to predict the presence of subclinical CAD in a high-risk population of women with a history of preeclampsia.