Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage, including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated. (A systemic mineral imbalance would elevate calcium levels in the blood and all tissues and cause metastatic calcification.) Basophilic calcium salt deposits aggregate, first in the mitochondria, and progressively throughout the cell. These calcifications are an indication of previous microscopic cell injury. It occurs in areas of cell necrosis in which activated phosphatases bind calcium ions to phospholipids in the membrane. Calcification can occur in dead or degenerated tissue. Caseous necrosis in T.B. is most common site of dystrophic calcification. Liquefactive necrosis in chronic abscesses may get calcified. Fat necrosis ...
Synonyms for dystrophic calcification in Free Thesaurus. Antonyms for dystrophic calcification. 8 words related to calcification: chemical action, chemical change, chemical process, ossification, hardening, inaction, inactiveness, inactivity. What are synonyms for dystrophic calcification?
TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. "pathophysiology and management". Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. "Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases". Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. "Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy". Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
MalaCards based summary : Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related An important gene associated with Hyperphosphatemic Familial Tumoral Calcinosis, Fgf23-Related is FGF23 (Fibroblast Growth Factor 23 ...
Mitral annular calcification (MAC) and aortic annular calcification (AVC) may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes. To examine the relationship between the degree of calcification at mitral and/or aortic valve annulus and large artery structure (thickness). We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP), pulse pressure (PP=SBP-DBP), body mass index (BMI), fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular/annular lesions independent scores based on acoustic densitometry: 1 = annular/valvular sclerosis/calcification absence; 2 = annular/valvular sclerosis; 3 = annular calcification; 4 =
In addition to fibrosis, calcification is a defining feature of aortic valve lesions. Calcification may contribute to lesion rigidity, thereby worsening obstruction to left ventricular outflow. Moreover, the extent of lesion calcification correlates both with more rapid disease progression and worse clinical outcomes.61,62. Aortic valve calcification now has been shown unequivocally to be an active, rather than a passive, process. Valvular calcium deposits contain both calcium and phosphate11,57,63,63 as hydroxyapatite,57,63 the form of calcium-phosphate mineral present in both calcified arterial tissue64 and bone. Proteins involved in regulation of tissue calcification have been detected in calcified valvular tissue, including osteopontin,13,14 bone morphogenic proteins (BMPs) 2 and 4,15 and receptor activator of nuclear factor NF-κB ligand (RANKL).65 Osteoprotegrin (OPG), which prevents mineral resorption in bone tissue, is a soluble decoy receptor that resembles RANK and acts as a ...
INTRODUCTION. Soft tissue radiopacities include calcification, ossification or foreign objects. The latter are excluded from this manuscript. Calcification is the deposition of calcium salts in tissue. The pathogenesis is based on either dystrophic or metastatic mechanisms. Dystrophic calcification, which comprises the majority of soft tissue calcifications in the head and neck region, is the result of soft tissue damage with tissue degeneration and necrosis which attracts the precipitation of calcium salts. The blood calcium concentration in these patients is normal. Appropriate examples are calcification of a focus of necrosis of tuberculosis, necrotic tumour tissue or of atheromatous plaque.. Metastatic calcification on the other hand results from the deposition of calcium salts in normal tissue in the presence of hypercalcemia secondary to metabolic causes such as hyperparathyroidism and skeletal deposits of malignant disease. Metastatic calcifications are therefore generally spread more ...
Looking for coronary artery calcification? Find out information about coronary artery calcification. Any process of soil formation in which the soil colloids are saturated to a high degree with exchangeable calcium, thus rendering them relatively immobile... Explanation of coronary artery calcification
Background and Aim: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT). Methods: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations. Results: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a radiologist
Background: Clinical evidence links arterial calcification and cardiovascular risk. Fibrous cap microcalcifications can promote atherosclerotic plaque failure, and large calcifications can stabilize the plaque. Therefore, calcification morphology can determine cardiovascular morbidity, but temporal patterns of calcific mineral deposition and growth remain unknown.. Results: Apolipoprotein E-deficient (Apoe-/-) mice on an atherogenic diet develop plaque calcification. Longitudinal studies were performed using two different fluorescent calcium tracers injected intravenously into Apoe-/- mice: calcein injection following 18 weeks of atherogenic diet (n=7) and alizarin red S injection into the same mice 1 (n=4) or 3 (n=3) weeks later. Imaging green (calcein) and red (alizarin red S) fluorescence provided snapshots of aortic calcification at 18, 19, and 21 weeks. Observations within histological sections revealed green microcalcifications at 18 weeks embedded within alizarin red stained larger ...
Two brothers aged 10 years and 18 years presented with multiple soft tissue calcareous swellings around the elbows, arms, knees, and forearms, which had been present for the last three years. Both were in good general health and there was no history of trauma. On examination, the younger boy had a calcified soft tissue swelling around the left knee joint with a sinus around the medial side of the knee. There was occasional discharge of white chalky material from the sinus. Movements at the knee were full and there was no neurovascular problem. The other brother had calcareous, firm, soft tissue swellings over the right lower thigh, left and right arms, and around both the elbow joints. Movements at the elbow and knee joints were normal and he had no discharging sinus. Their serum calcium, serum phosphorus, alkaline phosphatase, and urinary calcium were within normal limits. The erythrocyte sedimentation rate and the leukocyte count were normal. A test for lupus erythematosus was negative and ...
To the best of our knowledge, the present IVUS study is the first to demonstrate the relationship between calcification patterns, arterial remodeling, and the morphology of plaques within the culprit lesion segment. The major finding is that there is a significant difference in the pattern of coronary calcifications at the culprit lesion segment, particularly with respect to size, number, and length of the deposits, among patients with AMI, UAP, and SAP. Small calcium deposits were significantly more frequent in the culprit lesion segments in ACS than in SAP patients. In fact, our qualitative analysis of calcifications demonstrated that the culprit segments of AMI patients were mostly characterized by small calcium deposits, associated with fibrofatty plaques and PR.. Thus far, there have been few quantitative IVUS studies of coronary plaque calcification in lesions associated with ACS. Nakamura et al8 recently reported that lesser degrees of calcium were observed in the culprit lesions of ACS ...
Intervention study focused on preventing the progression of aortic valve calcification. Vascular and cardiac calcifications are a marker of risk and po
TY - JOUR. T1 - Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the multi-ethnic study of atherosclerosis). AU - Cohen, Randy. AU - Budoff, Matthew. AU - McClelland, Robyn L.. AU - Sillau, Stefan. AU - Burke, Gregory. AU - Blaha, Michael. AU - Szklo, Moyses. AU - Uretsky, Seth. AU - Rozanski, Alan. AU - Shea, Steven. PY - 2014/10/15. Y1 - 2014/10/15. N2 - Although a coronary artery calcium (CAC) score of 0 is associated with a very low 10-year risk for cardiac events, this risk is nonzero. Subjects with a family history of coronary heart disease (CHD) has been associated with more subclinical atherosclerosis than subjects without a family history of CHD. The purpose of this study was to assess the significance of a family history for CHD in subjects with a CAC score of 0. The Multi-Ethnic Study of Atherosclerosis cohort includes 6,814 participants free of clinical cardiovascular disease (CVD) at baseline. Positive ...
Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, ...
2017, Springer Science+Business Media B.V., part of Springer Nature. Purpose: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients. Methods: Four hundred and nineteen patients were included. Lateral abdominal and pelvic radiographs were obtained. The degree of AAC and PAC was evaluated according to the methods described previously by Kaupplia et al. and Adragao et al. ...
Cardiovascular diseases represent the most common cause of global mortality (31%), affecting both developed and developing countries, claiming the lives of an estimated 17.5 million people in 2012 (1-3). Among the predictors for cardiovascular morbidity and mortality, cardiovascular calcification is an independent risk factor. Many pathologies, such as atherosclerosis, diabetes mellitus, and chronic kidney disease, are often associated with cardiovascular calcification (4, 5), which can occur in blood vessels, the myocardium, and cardiac valves. In blood vessels, calcification typically occurs in intimal atherosclerotic plaques and in the tunica media (4, 6-8).. In the past two decades, research has highlighted the active inflammatory and/or osteogenic signaling processes that contribute to pathological cardiovascular calcification, shifting the paradigm away from that of a passive accumulation of minerals (9, 10). However, very little is known about the mechanism of nonpathological mineral ...
In a study to ascertain whether breast arterial calcification (BAC) detected with digital mammography correlates to chest CT findings of coronary artery calcification (CAC), researchers have discovered a striking relationship between the two factors. In 76 percent of the study cohort, women who had a BAC score of 0 also had a CAC score of 0. As the BAC score increases, there is a concomitant increase in the CAC score.
Background: Recent guidelines have suggested that presence of coronary artery calcium (CAC) is an independent marker of adverse cardiovascular disease (CVD) events and mortality. However the predictive value of thoracic aorta calcification (TAC) that can be additionally identified without further scanning during assessment of CAC is unknown.. Method: We followed a cohort of 8418 asymptomatic individuals (mean age: 53 ± 10 years, 69% men) undergoing cardiac risk factor evaluation and coronary calcium testing with electron-beam CT for median period of 5.0 years. Multivariable Cox proportional hazards models were developed to predict all-cause mortality obtained from the National Death Index with presence of TAC.. Results: 141 (2%) all cause deaths were recorded. Overall survival was 96.7% and 98.8% for subjects with and without detectable TAC (p , 0.0001). As compared to those with absent TAC (reference group) the hazard ratio for mortality for subjects with TAC was 3.07 (95% CI: 2.20 - 4.38) in ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
BACKGROUND:. This study is ancillary to the MultiEthnic Study of Atherosclerosis (MESA) Trial, a prospective investigation of the etiology and natural history of atherosclerosis and the ability of non-invasive tools to measure atherosclerotic burden and identify high risk individuals in a large, population-based cohort. The development of computed tomography (CT) to evaluate coronary calcification (CC) now provides a tool to directly measure coronary atherosclerosis non-invasively. The information obtained by CT however provides more information than CC alone. CT has the ability to measure and quantitate aortic valve calcification (AVC), mitral annular calcification (MAC), aortic wall calcification and left ventricular size (LVS). The longitudinal nature of this study will allow epidemiologic associations to be established for a multitude of risk factors and these measures, establishing both the time sequence for each measure and consistency of the association in a variety of populations ...
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
This 15 year longitudinal study provides insights into the relationship between coronary artery calcification and diabetes mellitus. Abstract Background Data regarding coronary artery calcification (CAC) prognosis in diabetic individuals are limited to 5-years follow-up. We investigated the long-term risk stratification of CAC among diabetic compared with nondiabetic individuals. Methods and Results Nine thousand seven…
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In a previous study ([17]) performed in the same patient group as that in the present study, the total coronary calcification score predicted coronary stenosis. The sensitivity, specificity, PPV, NPV and accuracy of the total calcification score were 0.77, 0.86, 0.86, 0.76 and 0.81, respectively. The sensitivity (0.75), specificity (0.81) and accuracy (0.80) of calcification for prediction of significant stenosis was similar in the present study, but the PPV (0.36) was significantly lower (p , 0.0001 by chi-square analysis) and the NPV (0.96) significantly higher (p , 0.0001). These differences were revealed by the site by site comparison. As in our previous study ([17]), the prevalence and amount of coronary calcification increased with age, even in patients without significant stenosis. These findings may explain why the PPV and sensitivity increased significantly with age for all atherosclerotic lesions. The PPV and sensitivity did not increase with age for significant stenosis. Although the ...
The present study examined the diagnostic performance of FFRCT at various levels of coronary calcification for the identification and exclusion of ischemia-causing lesions using FFR as the reference standard. The 2 major findings of this study were: 1) FFRCT provided high per-patient and per-vessel diagnostic performance and discrimination for ischemia over a wide range of coronary calcification severity; and 2) the diagnostic performance of FFRCT was superior to coronary CTA stenosis interpretation regardless of the AS level.. Because the presence of myocardial ischemia is associated with a poor prognosis (23), current guidelines recommend noninvasive functional imaging testing as the first-line strategy in patients with suspected stable CAD (21). However, shortcomings of current noninvasive diagnostic strategies are apparent from the frequent inaccurate selection of patients for ICA (24,25). To date, FFR is the only diagnostic tool shown to improve clinical outcomes and to reduce health care ...
Idiopathic Infantile Arterial Calcification (IIAC) also known as Arterial Calcification of Infancy, Generalised Infantile Arterial Calcification (GACI), Idiopathic Arterial Calcification of Infancy (IACI), Occlusive Infantile Arterial Calcification, Occlusive Infantile Arteriopathy is an extremely rare, usually fatal genetic disorder, caused by mutations in the ENPP1 gene in 75% of the subjects. The condition affects infants during the first 6 months of life. This condition is inherited as an autosomal recessive pattern. It is characterized by generalised calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. Most infants die of vaso-occlusive disease, especially of the coronary arteries. Clinical presentation is variable. First symptoms usually occur at birth but can take place in the first 6 months of life or in utero. Decreased fetal activity Gestation with an ...
DESIGN: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatstons method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors ...
A database of 145 mammograms containing biopsy proven malignant or benign microcalcifications was digitized with a laser scanner at a pixel size of 35 micrometer by 35 micrometers. Digitization at larger pixel sizes was simulated by averaging adjacent pixels. The individual microcalcifications were segmented from the digital images with region growing and adaptive gray level thresholding techniques. The characteristics of the individual microcalcifications were analyzed with visibility descriptors and shape descriptors. The variations of visibility and shape of the microcalcifications in a cluster were evaluated by the standard deviation, the coefficient of variation, and the maximum of each of the descriptors. In addition, texture features were extracted from the spatial gray level dependence (SGLD) matrices in the region containing the cluster of microcalcifications. A genetic algorithm (GA) was used to select features from the multidimensional morphological and texture feature space. Linear ...
Comments, concepts and statistics about Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study.
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia). Normalization of elevated serum calcium occurs within a few days of treatment withdrawal (ie, faster than in treatment with vitamin D3 preparations). Chronic hypercalcemia may lead to generalized calcification, nephrocalcinosis and other soft tissue calcification. The serum calcium times phosphate (Ca X P) product should not exceed 70 mg2/dL2. Overdose may require immediate medical attention ...
Vascular and valvular calcification are commonly encountered in clinical medicine and a greater understanding of their significance and pathophysiology remain a subject of immense importance. In the coronary arteries, vascular calcification burden correlates with the severity of luminal stenosis and atherosclerotic plaque burden. While in progressive lesions, the presence of coronary calcification is not binary but rather depends on the type of calcification. Racial and gender differences, and comorbidities like diabetes mellitus and chronic kidney disease, all affect the presence and severity of calcification. The peripheral arteries of the lower extremities are affected by both medial calcification and intimal calcification, and the former barely contributes to luminal stenosis. The character of atherosclerosis differs between above-knee and below-knee lesions. Valvular calcification generally occurs on the aortic valve leaflets, and pathologic findings range from minimal fibrocalcific changes in
Purpose: Soft tissue calcification is a pathological condition. In arterial calcification, the elastic lamina is the first site of mineral deposition leading to increased arterial stiffness and higher systolic blood pressure. MGP is a potent mineralization inhibitor secreted by chondrocytes in cartilage and VSMC in arteries where colocalizes with elastin. Mgp-deficient mice die at 6 wks due to massive artery calcification. An Mgp Knock-In (KI) mouse showed high Mgp expression in the eye uniquely targeted to trabecular meshwork (TM) and sclera. Since scleral stiffness affects optic nerve damage, we investigated sclerals Mgp spatial/temporal distribution in the KI and ppSCs calcification in the KO.. Methods: The KI DNA in our Mgp-Cre mouse contains the Mgp gene, 2 kb promoter, 3 kb 3UTR and an IRES-Cre cassette inserted in between. This mouse was crossed with a Cre-mediated reporter line R26R-lacZ. Their offspring expresses lacZ (β-gal) where Mgp is transcribed. Eyes from MgpCre/+;R26RlacZ/+ ...
TY - JOUR. T1 - Brief Report. T2 - Aging Attenuates the Association between Coronary Artery Calcification and Bone Loss among HIV-Infected Persons. AU - Escota, Gerome. AU - Baker, Jason. AU - Bush, Tim. AU - Conley, Lois. AU - Brooks, John T.. AU - Patel, Pragna. AU - Powderly, William. AU - Presti, Rachel. AU - Overton, Edgar T.. PY - 2019/9/1. Y1 - 2019/9/1. N2 - Introduction:Studies among HIV-uninfected persons (mostly in their sixth decade of life) show that detectable coronary artery calcium (CAC) is independently associated with low bone mineral density (BMD), suggesting a possible common pathogenic mechanism.Aim:We assessed the relationship between CAC and BMD, which has not been well described among younger to middle-aged HIV-infected persons.Methods:We studied participants with baseline CAC and BMD measures from a prospective cohort of HIV-infected persons enrolled in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) during 2004-2006. We used ...
A method and system for detecting and displaying clustered microcalcifications in a digital mammogram, wherein a single digital mammogram is first automatically cropped to a breast area sub-image which is then processed by means of an optimized Difference of Gaussians filter to enhance the appearance of potential microcalcifications in the sub-image. The potential microcalcifications are thresholded, clusters are detected, features are computed for the detected clusters, and the clusters are classified as either suspicious or not suspicious by means of a neural network. Thresholding is preferably by sloping local thresholding, but may also be performed by global and dual-local thresholding. The locations in the original digital mammogram of the suspicious detected clustered microcalcifications are indicated. Parameters for use in the detection and thresholding portions of the system are computer-optimized by means of a genetic algorithm. The results of the system are optimally combined with a
Atherosclerotic cardiovascular disease (ASCVD),including coronary heart disease, remains a major cause of death and disability among developed countries. Coronary artery calcification (CAC), which is detected by computed tomography scanning, is a well-known measure of subclinical atherosclerosis. CAC is considered to have important implications for understanding the long-term accumulated burden of cardiovascular risk factors and for the possibility of reclassification at the preclinical phase for preventing ASCVD. This review focuses on CAC and its usability in primary prevention of ASCVD. Numerous epidemiological studies, mainly in Western countries, have indicated that, among asymptomatic individuals, the CAC score is associated with future ASCVD. Additionally, the CAC score provides improved predictive values for estimating the risk of ASCVD beyond traditional cardiovascular risk factors. However, a lack of evidence for this score in other populations warrants further investigations. ...
This is a photo of a calcium deposit (calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN Photo Repository.
Premier Radiology offers CT of the coronary calcium score, Coronary calcification occurs when calcium deposits in your blood vessels.
Increased magnesium intake has been observed to lower the risk of adverse cardiac events including stroke, nonfatal myocardial infarction, and cardiac death, and it is thought that increased magnesium may slow or prevent arterial calcification and plaque formation. The present findings suggest that increased calcium intake may be associated with a reduction in arterial calcification in a large population of asymptomatic individuals without known cardiovascular disease. Increased arterial calcification correlates with greater overall plaque burden, and has been robustly demonstrated to convey increased cardiovascular risk. Nevertheless, some research suggests that calcified plaque may be less vulnerable than mixed or noncalcified plaque, and this study cannot assess whether these other types of plaque are also decreased in patients with increased magnesium intake. These findings support the hypothesis that increased magnesium intake may reduce cardiovascular risk, and should prompt future ...
Case Reports in Obstetrics and Gynecology is a peer-reviewed, Open Access journal that publishes case reports and case series related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, and reproductive endocrinology.
OHTAKE, T., ISHIOKA, K., HONDA, K., OKA, M., MAESATO, K., MANO, T., IKEE, R., MORIYA, H., HIDAKA, S. and KOBAYASHI, S. (2010), Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis. Hemodialysis International, 14: 218-225. doi: 10.1111/j.1542-4758.2009.00423.x ...
porcelain aorta - stl file processed This file was created with democratiz3D. Automatically create 3D printable models from CT scans. Learn more. porcelain aorta, ct with contrast, scan, dicom, axial, thorax, heart, aorta, descending, ascending, porcelain, arch, bronchus, lung, pulmonary, trunk, arteries, great, vessels, calcification, ribs, chest Calcification of the thoracic aorta is often associated with valvular and coronary calcification, reflecting an underlying atherosclerotic process. It has been found to be associated with an increased rate of mortality and cardiovascular disease. Porcelain aorta (PA) is extensive calcification of the ascending aorta or aortic arch that can be completely or near completely circumferential. This entity is rare in the general population, but it has an increasing incidence in older patients and in patients with coronary artery disease (CAD) or aortic stenosis (AS). The clinical relevance is based on the fact that it can complicate surgical aortic valve ...
1200 words Last week a study was published stating that white men who exercised 3 times the recommendation of 1.5 hours (450 minutes, 7.5 hours) had a higher chance of getting coronary artery calcification (CAC), which is the accumulation of plaque and calcium in the arteries of the heart. You, of course see news headlines…
Human 12/15-lipoxygenase (ALOX15) catalyzes the oxidation of polyunsaturated fatty acids and has been implicated in the pathogenesis of atherosclerosis. We previously reported that a common haplotype of the ALOX15 gene is associated with higher prevalence of coronary artery calcification in a cohort of middle-aged African-Americans. This haplotype was uniquely tagged by a promoter variant (rs2255888). We carried out an in vitro characterization of this promoter variant to further investigate regulatory mechanisms of the ALOX15 gene. We evaluated the activity of ALOX15 variant A-carrying and wild type G-carrying promoter haplotypes using a luciferase assay. We demonstrated a 65% higher activity of the A-carrying promoter haplotype as compared to the G-carrying promoter haplotype. Using mass-spectrometry and electrophoretic mobility shift assay we showed that vimentin, a structural protein, specifically binds to both A-carrying and G-carrying promoter haplotypes in vitro. However, the A ...
Howlett, P, Waheed, A, Horton, A, Shah, N, Leatham, E, Wu, H, Gerber, A and Mahmoudi, M (2015) MICRORNAS REPRESENT NOVEL BIOLOGICAL MARKERS OF CORONARY ARTERY CALCIFICATION In: British-Cardiac-Society (BCS) Annual Conference on Hearts and Genes, 2015-06-08 - 2015-06-10, Manchester, ENGLAND. Full text not available from this repository ...
Imaging of vascular calcification is increasingly used for cardiovascular screening purposes in asymptomatic patients. Coronary and aortic calcium deposits in the vascular wall have been shown to be related to atherosclerotic plaque burden. New imaging techniques with electron beam computed tomography (EBCT) and multi-slice computed tomography (MSCT), to measure the ... read more calcium content in the coronary arteries, are promising methods for clinical risk assessment. However, the rising costs of these emerging cardiac imaging techniques and the radiation exposure involved demand a more critical evaluation of already existing and less expensive technology. In this thesis we have investigated whether arterial calcifications that are frequently seen on mammograms may serve as a screening tool for atherosclerotic risk assessment in women. The simultaneous use of mammograms for screening on breast cancer and atherosclerotic disease could be very cost-effective. Based on our findings in two ...