F. Cundy, J. A. Kanis, G. Heynen, M. Earnshaw, T. L. Clemens, J. L. H. ORiordan, A. L. Merritt, J. E. Compston; Lack of Direct Effect of 1,25-Dihydroxy-Vitamin D3 on Mineralization of Bone and Secretion of Parathyroid Hormone. Clin Sci (Lond) 1 September 1980; 59 (3): 15P. doi: https://doi.org/10.1042/cs059015P. Download citation file:. ...
The importance of Wnt pathway signaling in development of bone has been well established. Here we investigated the role of a known Wnt target, ENC1 (ectodermal-neural cortex 1; NRP/B), in osteoblast differentiation. Enc1 expression was detected in mouse osteoblasts, chondrocytes, and osteocytes by in situ hybridization, and osteoblastic expression was verified in differentiating primary cultures and MC3T3-E1 pre-osteoblast cells, with 57 kDa and 67 kDa ENC1 protein isoforms detected throughout differentiation. Induced knockdown of both ENC1 isoforms reduced alkaline phosphatase staining and virtually abolished MC3T3-E1 mineralization. At culture confluence, Alpl (alkaline phosphatase liver/bone/kidney) expression was markedly reduced compared with control cells, and there was significant and coordinated alteration of other genes involved in cellular phosphate biochemistry. In contrast, with 67 kDa-selective knockdown mineralized nodule formation was enhanced and there was a two-fold increase in Alpl
Principal Investigator:SASAGAWA Ichiro, Project Period (FY):1993 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Morphological basic dentistry
Acidification of slurry through dietary manipulation of urinary pH is a means of mitigating nitrogen emission from pig production, but long-term effects of diet acidification on bone mineralization and mineral balance is less investigated. The objective was therefore to study the long-term effects of feeding benzoic acid (BA) and calcium chloride (CaCl2) on the mineral balance and microbial activity in the gastrointestinal tract of pigs. Four diets containing the combinations of 0 or 10 g/kg BA and 0 or 20 g/kg CaCl2 were fed to 24 pigs in a factorial design. For the diets without CaCl2, calcium carbonate (CaCO3) was added to provide equimolar levels of Ca. The pigs were fed the diets from 36 kg until slaughter at 113 kg BW, and they were housed in balance cages for 12 d from 60 to 66 kg BW. Supplementation of BA and/or CaCl2 had only minor effect on accumulation of digesta organic acids (acetate, propionate, butyrate and lactate) throughout the gastrointestinal tract. A reduction (P , 0.01) in ...
Background: Inhaled corticosteroids (ICS) are the drugs of choice for asthma. Corticosteroids can have many detrimental effects on bone mineralization and growth, despite of inhaled administration.. Aims and objectives: To evaluate the association between the long-term use of ICS in childhood and bone mineral density (BMD) in teenagers.. Methods: Ninety-one children hospitalized for wheezing at age ,24 months were prospectively followed until 12.2 (median) years of age. Data on ICS use were collected by interviewing the parents, supplemented by data from patient records. Cumulative doses, the duration of ICS use and systemic steroid doses were calculated. At the last check-up, BMD (BMDareal, g/cm2) was measured by dual energy X-ray absorptiometry (DXA) in 89 children, and apparent volumetric BMDs (aBMDvol, g/cm3) were calculated for the lumbar spine and femoral neck. Weight, height and pubertal stage were recorded.. Results: The regular use of ICS at age ,6 years was associated with a lower ...
rine calcification rates will change in the future the report warns t......,Report,warns,about,carbon,dioxide,threats,to,marine,life,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
The ICCBMT conference series, which has been held every three years or so since , is one of the most important scientific gatherings in the field of biological mineralization. The meeting emphasizes a wealth of physicochemical, biological and clinical topics concerning mineralization processes in vertebrate and invertebrate species.
Investigating the effect of increasing concentrations of β-glycerophosphate on 4T1 cell mineralization.Representative images were captured at 100× magnificati
Published in: Premières Journées JCSEE1 - Chimie, soleil, énergie et environnement, Saint-Avold, France, 3-4 févr. 2000, p. 10 ...
Read Comparison on mineralization of 2,4,6-tribromophenol by UV-based advanced oxidation processes: UV/Na2S2O8 and UV/H2O2, Research on Chemical Intermediates on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Infants will be randomly assigned to one of 3 study groups. Group 1 - physical activity once a day. Group 2 - physical activity twice a day and group 3 - control.. The physical activity program is based on the Moyer-Mileur et al protocol (1). Briefly, this protocol involves extension and flexion range-of-motion exercise against passive resistance of both the upper and lower extremities. Both extension and flexion were performed five times at the wrist, elbow, shoulder, ankle, knee, and hip joints (about 10 minutes for each session). Infant in group 1 have the physical activity intervention once a day, 5 days a week. Infant in group 2 will have the same physical activity intervention twice a day, five times a week. Infant in group 3, the control group will have a similar time (10 minutes) of daily interactive periods of holding and stroking without range-of-motion activity.. The physical activity will be done by the same person (the NICU physiotherapist) Growth parameters, and bone strength, will ...
Defective bone mineralization has serious clinical manifestations, including deformities and fractures, but the regulation of this extracellular process is not fully understood. We have developed a mathematical model consisting of ordinary differential equations that describe collagen maturation, production and degradation of inhibitors, and mineral nucleation and growth. We examined the roles of individual processes in generating normal and abnormal mineralization patterns characterized using two outcome measures: mineralization lag time and degree of mineralization. Model parameters describing the formation of hydroxyapatite mineral on the nucleating centers most potently affected the degree of mineralization, while the parameters describing inhibitor homeostasis most effectively changed the mineralization lag time. Of interest, a parameter describing the rate of matrix maturation emerged as being capable of counter-intuitively increasing both the mineralization lag time and the degree of
The present review aims to systematically and critically analyze the current knowledge on phospholipases and their role in physiological and pathological mineralization undertaken by mineralization competent cells. Cellular lipid metabolism plays an important role in biological mineralization. The physiological mechanisms of mineralization are likely to take place in tissues other than in bones and teeth under specific pathological conditions. For instance, vascular calcification in arteries of patients with renal failure, diabetes mellitus or atherosclerosis recapitulates the mechanisms of bone formation. Osteoporosis-a bone resorbing disease-and rheumatoid arthritis originating from the inflammation in the synovium are also affected by cellular lipid metabolism. The focus is on the lipid metabolism due to the effects of dietary lipids on bone health. These and other phenomena indicate that phospholipases may participate in bone remodelling as evidenced by their expression in smooth muscle cells, in
Objective: To evaluate the effects of osteoformin on mineralisation and quality of the new bone formation during rapid distraction osteogenesis. ...
In the Sahel region in Africa, and in most arid regions, groundwater is the crucial source for water supply since surface water is scarce. This study aimed to understand a complex geochemical mechanism controlling the mineralization process in the Taoudeni Basin. A thousand randomly distributed groundwater samples acquired from different aquifers were used for this research. The results show that the majority of the samples observed are of the Ca2+-Mg2+-HCO3− and Na+-HCO3− types depending on the different aquifers. Mg2+ and Ca2+ may react with HCO3− precipitating as calcite and dolomite. The Na+-HCO3− groundwater type is mainly derived from the ion exchange process. This type indicates a paleo-marine depositional environment or that it passes through paleo-marine channels. Calcium of the standard Ca2+-HCO3− groundwater type exchanges with the sodium. Groundwater is characterized by the water-rock interactions that indicate the chemical alteration of the rock-forming
Channel Sampling is carried out on rocks exposed thats usually done on outcrops, trenches, and walls of a typical exploration and mine stage projects. This procedure of sampling is done by cutting much narrow channels on the rocks surface. Channels in some cases can be made by using a chisel and a hammer, or a diamond saw. One of the best techniques in obtaining channel samples from a specific location is done by using a diamond saw. The reasoning why diamond cutting is pronounced for its cutting ability is because better channel samples of significant quality are obtained. Channels are generally cut through the whole entire vein system or ore-body being sampled, and extend to the wall rocks. This largely depends on the thickness of the mineralization being sampled, and can be tens of metres. Length of each individual sample is known to also vary from 10 cm to 100 cm that largely depends on mineralization style. Width of channels can also range from 5-10 cm, and a depth of approximately 3-5 cm. ...
Inhibition of PPAR gamma 2 by BADGE and Vitamin D in Male Mice Increases Osteoblastogenesis and Inhibits Bone Matrix Mineralization Leading to Osteomalacia. Conference Proceedings ...
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Rheumatology (Oxford). 2016 Oct;55(10):1714-25. Epub 2016 Jan 20. DOI: 10.1093/rheumatology/kev410 PMID: 26790456 [PubMed - in process]. Traditional BTMs have been used for years to help with fracture risk prediction and in particular for treatment monitoring. Clinical use of the new biochemical markers has not been established so far. Their relationship with fracture risk is still under investigation, and their use as treatment monitoring tools needs to be studied. In fact, their role is probably dependent on a new approach based on our understanding of bone physiology. These new markers will be helpful for exploring the physiological and pathological relations between the bone and other organs, and to monitor joint diseases, chronic kidney disease - mineral and bone disorder (CKD-MBD) and cardiovascular disease. mechanisms in the bone or other organs.. ...
Phosphatases are essential for the mineralization of the extracellular matrix within the skeleton. Their precise identities and functions however remain unclear. PHOSPHO1 is a phosphoethanolamine/phosphocholine phosphatase involved in the generation of inorganic phosphate for bone mineralization. It …
PURPOSE: To test our hypothesis that differences in urinary calcium excretion among blacks and whites may be secondary to ethnic variations in acid (H(+)) metabolism and to prove that increases in titratable acid excretion would be found among indivi
Introduction The difficulty in re-growing and mineralizing new bone after severe fracture can result in loss of ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing gene expression, cell growth and BMP-2 in gene expression and mineralization of bone. Materials and methods The regulation of gene expression was determined using real-time RTPCR (qRTPCR) and cell proliferation was measured by thymidine incorporation or fluorescent analysis of DNA content in MC3T3E1 osteoblast-like cells. Photomicroscopy was used to identify newly mineralized tissue and fluorescence was used to quantify mineralization. Results Fibroblast growth factor-2 (FGF-2) had the greatest ability to induce proliferation after 24 hours of treatment when compared to transforming growth factor beta (TGFβ, insulin-like growth factor-1 (IGF-1), bone morphogenic protein (BMP-2), platelet derived growth factor (PDGF) or prostaglandin E2 (PGE2). We found that FGF-2 caused the most significant induction of ...
In osteoporosis, the bone displays normal mineralization. In contrast, osteomalacia is characterized by defective mineralization. Histological examination reveals an increase in the amount of unmineralized bone and disorganized trabecular architecture. Of note, mineralization can only be assessed using special techniques not requiring decalcification of tissue specimens prior to staining ...
Gallery of pictures of the mineral Jamesonite taken for the purpose of training others for Jamesonite identification of rock and mineral Jamesonite specimens.
Alignment, Bone Mineralization, Calcifications, Distribution Of Joints, Erosions, Soft Tissue And Nails [x-ray Features In Arthritis ...
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By: Dr. Robin B. Dilley, author of In A Moments Notice: A Psychologists Journey with Breast Cancer and a licensed psychologist.. I have written before about this ancient symbol, The Labyrinth. However, I want to write again as I believe in the synchronicity of all events in each of our lives and that information that we need arrives just at the time we need it. I just returned from nine days of being immersed in all things Labyrinth. I returned knowing again that the Labyrinth has something important to share, especially with cancer patients.. That is something you and I have in common. We have been touched by cancer in one form or another and we are learning together how to manage the fear as well the changes to our lives that are so necessary to help us manage the disease with adjunctive holistic approaches such as yoga, exercise, clean eating and spiritual and psychological health.. Each of us are somewhere in our journey of treatment, maybe beginning, middle, or management stage. We did ...
Several denialists have sort to deliberately confuse the readership over the important evidence gathered by Death et al. (2009) on slowing coral calcification on the Great Barrier Reef. Given the recent resurgence in this misinformation, I thought it would be a good idea to post Dr Glenn Death, Dr Janice M. Lough and Dr Katharina E. Fabriciuss recent reply to Dr Peter Ridds confused and misleading claims. The maintenance of coral calcification rates is critical for the future of coral reefs and it is, therefore, important to identify spatial patterns and temporal trends in the rates of coral calcification. Our recent report showed that substantial declines in coral calcification have occurred on the Great Barrier Reef in the last 20 years (Death et al., 2009), and similar reports are now emerging from other parts of the world (Tanzil et al., 2009). Ridd et al. here suggest that (1) ontogenetic effects, and (2) the last data points at the end of the recent cores, largely explain the ~14% ...
Several denialists have sort to deliberately confuse the readership over the important evidence gathered by Death et al. (2009) on slowing coral calcification on the Great Barrier Reef. Given the recent resurgence in this misinformation, I thought it would be a good idea to post Dr Glenn Death, Dr Janice M. Lough and Dr Katharina E. Fabriciuss recent reply to Dr Peter Ridds confused and misleading claims. The maintenance of coral calcification rates is critical for the future of coral reefs and it is, therefore, important to identify spatial patterns and temporal trends in the rates of coral calcification. Our recent report showed that substantial declines in coral calcification have occurred on the Great Barrier Reef in the last 20 years (Death et al., 2009), and similar reports are now emerging from other parts of the world (Tanzil et al., 2009). Ridd et al. here suggest that (1) ontogenetic effects, and (2) the last data points at the end of the recent cores, largely explain the ~14% ...
Bone, tooth enamel, and dentin accumulate Sr 2+ , a natural trace element in the human body. Sr 2+ comes from dietary and environmental sources and is thought to play a key role in osteoporosis treatments. However, the underlying impacts of Sr 2+ on bone mineralization remain unclear and the use of synthetic apatites (which are structurally different from bone mineral) and non-physiological conditions have led to contradictory results. Here, we report on the formation of a new Sr 2+-rich and stable amorphous calcium phosphate phase, Sr(ACP). Relying on a bioinspired pathway, a series of Sr 2+ substituted hydroxya-patite (HA) that combines the major bone mineral features is depicted as model to investigate how this phase forms and Sr 2+ affects bone. In addition, by means of a comprehensive investigation the biominer-alization pathway of Sr 2+ bearing HA is described showing that not more than 10 at% of Sr 2+ , i.e. a physiological limit incorporated in bone, can be incorporated into HA without phase
Purpureocillium lilacinum can promote the biomineralization of jarosite by secreting extracellular polymeric substances (EPS), but the detailed mechanism is not clear. In this study, the biosynthesis process of jarosite induced by P. lilacinum Y3 and hypha cell surface characterization were investigated. X-ray diffraction (XRD) analysis indicated that P. lilacinum Y3 could induce the formation of jarosite crystal and enhance mineralization kinetics. The kinetic and isotherm models confirmed that the metal ions transferring from the solution to the mycelium surface was controlled by diffusion process and the active interfacial sites on hypha cell surface played a pivotal role in the biomineralization process. Furthermore, transmission electron microscopy (TEM) pictures illustrated that the P. lilacinum Y3 mainly induced the generation of mineral precipitate extracellularly, but not intracellularly. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectrum results further ...
This study will investigated Asfotase Alfa in patients with hypophosphatasia who completed the investigator-initiated clinical study (HPPJEAP-01) protocol for
Sigma-Aldrich offers abstracts and full-text articles by [Stephanie Graser, Birgit Mentrup, Doris Schneider, Ludger Klein-Hitpass, Franz Jakob, Christine Hofmann].
PURPOSE: Mineralization distribution of the subchondral bone plate can be used as a marker for long-term stress distribution in diarthrodial joints. Severe injuries or pathological changes of the glenohumeral joint often end in osteoarthritis, where shoulder arthroplasty has become the treatment of choice. The computed tomography osteoabsorptiometry (CT-OAM) is a non-invasive method to determine the distribution of the mineralization of the subchondral bone plate in vivo, which is an important factor concerning the implantation of orthopedic endoprostheses. The aim of this study was to investigate the mineralization of both joint partners of the glenohumeral joint and to compare them with each other. METHODS: The distribution of the mineralization of the subchondral bone plate of 57 shoulder specimens was determined by means of CT-OAM. To evaluate a correlation between age and localization of subchondral mineralization maxima, the Chi-square test correlation test was applied. RESULTS: Forty-nine ...
Epidemiological and preclinical studies have shown both parallel and reciprocal changes in arterial versus skeletal mineralization. Whereas inflammatory lipids and cytokines appear to promote vascular calcification but inhibit bone mineralization,57,123 some osteoanabolic agents, such as PTH and BMP-7, promote mineralization in the skeleton but suppress it in arteries.63,103,124. The clinical association of aortic calcification with osteoporosis, often age independent, suggests a link between vascular and bone metabolism.125-127 Three causality vectors may apply: (1) vascular calcification promoting bone loss, (2) bone loss promoting vascular calcification, or (3) a common etiology. The first possibility is largely unexplored, although bone loss may be promoted by stenoses of bone supply arteries or by systemic inflammation associated with atherosclerosis. The second possibility has more supportive evidence. Bone matrix is rich in regulatory factors that are also active in the vasculature, such ...
The small GTP-binding protein Rad (RRAD, Ras associated with diabetes) is the founding member of the RGK (Rad, Rem, Rem2, and Gem/Kir) family that regulates cardiac voltage-gated Ca(2+) channel function. However, its cellular and physiological functions outside of the heart remain to be elucidated. Here we report that Rad GTPase function is required for normal bone homeostasis in mice, as Rad deletion results in significantly lower bone mass and higher bone marrow adipose tissue (BMAT) levels. Dynamic histomorphometry in vivo and primary calvarial osteoblast assays in vitro demonstrate that bone formation and osteoblast mineralization rates are depressed, while in vitro osteoclast differentiation is increased, in the absence of Rad ...
Author(s): Ros, Gerard H.; Temminghoff, Erwin J.M.; Hoffland, Ellis | Abstract: Strong relationships between Extractable Organic N (EON) and N mineralization suggest that they can be used to assess the N mineralization potential of soils. EON is often used to proxy Dissolved Organic Nitrogen (DON), which is assumed to play an intermediate role in N mineralization. We tested whether EON relates to N mineralization and how this relation is affected by the extraction methodology used. We synthesized results from 171 papers on correlation coefficients between EON and N mineralization using meta-analysis. EON was positively related to N mineralization, and its size explained 14-65% of the variation in N mineralization. Best results were obtained with hot CaCl2 and acid KMnO4 as extractants. EON extracted with alkali solutions explained less of the variation in N mineralization than the other soil tests. There was no direct relationship between the intensity of extraction and the performance of EON as
The representation of cyclins and cyclin-dependent kinases (cdks) was analyzed during progressive development of the bone cell phenotype in cultures of normal diploid rat calvarial osteoblasts. Three developmental stages were examined: (a) proliferation; (b) monolayer confluency; and (c) mineralization of the bone extracellular matrix. We demonstrate that the presence of cyclins and cdks is not restricted to the proliferation period. Consistent with their role in cell cycle progression, cdc2 and cdk2 decrease postproliferatively. However, cdk4 and cyclins A, B, and D1 persist in confluent cells. Cyclin E is significantly up-regulated during the extracellular matrix mineralization developmental period. Examination of the cytoplasmic levels of these cell cycle regulatory proteins indicates a marked increase in cyclin B in the late differentiation stage. The elevation of nuclear cyclin E and cytoplasmic cyclin B is not observed in osteoblasts maintained under culture conditions that do not support
Cardiovascular Calcification And Bone Mineralization è un libro di Aikawa Elena (Curatore), Hutcheson Joshua D. (Curatore) edito da Humana a luglio 2021 - EAN 9783030467272: puoi acquistarlo sul sito HOEPLI.it, la grande libreria online.
2 levels may also play a role.[32]. Biomineralization evolved multiple times, independently,[35] and most animal lineages first expressed biomineralized components in the Cambrian period.[36] Many of the same processes are used in unrelated lineages, which suggests that biomineralization machinery was assembled from pre-existing off-the-shelf components already used for other purposes in the organism.[37] Although the biomachinery facilitating biomineralization is complex - involving signalling transmitters, inhibitors, and transcription factors - many elements of this toolkit are shared between phyla as diverse as corals, molluscs, and vertebrates.[38] The shared components tend to perform quite fundamental tasks, such as designating that cells will be used to create the minerals, whereas genes controlling more finely tuned aspects that occur later in the biomineralization process - such as the precise alignment and structure of the crystals produced - tend to be uniquely evolved in ...
2 levels may also play a role.[32] Biomineralization evolved multiple times, independently,[35] and most animal lineages first expressed biomineralized components in the Cambrian period.[36] Many of the same processes are used in unrelated lineages, which suggests that biomineralization machinery was assembled from pre-existing off-the-shelf components already used for other purposes in the organism.[37] Although the biomachinery facilitating biomineralization is complex - involving signalling transmitters, inhibitors, and transcription factors - many elements of this toolkit are shared between phyla as diverse as corals, molluscs, and vertebrates.[38] The shared components tend to perform quite fundamental tasks, such as designating that cells will be used to create the minerals, whereas genes controlling more finely tuned aspects that occur later in the biomineralization process - such as the precise alignment and structure of the crystals produced - tend to be uniquely evolved in ...
The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD). In this study we investigated the biological variance of the BMDD at the micrometer level, applying a quantitative backscattered electron imaging (qBEI) method. We used the mean calcium concentration (CaMean), the most frequent calcium concentration (CaPeak), and full width at half maximum (CaWidth) to characterize the BMDD. In none of the BMDD parameters were statistically significant differences found due to ethnicity (15 African-American vs. 27 Caucasian premenopausal women), skeletal site variance (20 ilium, 24 vertebral body, 13 patella, 13 femoral neck, and 13 femoral head), age (25 to 95 years), or gender. Additionally, the interindividual variance of CaMean and CaPeak, ...
We have shown that performance of highly repetitive tasks is associated with increased serum levels of IL-1alpha and increased activated macrophages in musculoskeletal tissues. Our purpose was to examine expression patterns of genes related to bone mineralization and inflammation in flexor forelimb muscles from young adult and aged (16 months) rats performing a repetitive reaching and grasping tas
1 uM dexamethasone, 10 mM B glycerolphosphate and 50 uM ascorbic new post acid for 14 days. The in duction medium was changed every 3 days, and the bone matrix mineralization was evaluated by Alizarin red S staining. The ARS was ex tracted by adding 10% cetylpyridinium chloride in 8 mM Na2HPO4 and 1. 5 mM KH2PO4 and the absorbance was mea sured by SpectraMax 190 ELISA plate reader at 550 nm. Cell proliferation assay To evaluate the cell proliferation, MTT 2,5 diphenyl 2H tetrazoliumbromide assay was performed as described previously. Briefly, cells were seeded at the density of 1. 5 103 cells/well in 96 well plate and cultured without or with various concentrations of OGT2115. Cells were analyzed every two days by adding Inhibitors,Modulators,Libraries 10 uL of the MTT to each well and the cells were continued to culture for 4 hr.. After the incubation, the supernatant was discarded and 100 uL of dimethyl sulfoxide was added to each well to dissolve the formazan. The number of cells was ...
Looking for online definition of cutaneous mineralization in the Medical Dictionary? cutaneous mineralization explanation free. What is cutaneous mineralization? Meaning of cutaneous mineralization medical term. What does cutaneous mineralization mean?
Introduction: Mutations in the gene ALPL in hypophosphatasia (HPP) reduce the function of tissue nonspecific alkaline phosphatase, and the resulting increase in pyrophosphate (PPi) contributes to bone and tooth mineralization defects by inhibiting physiologic calcium-phosphate (P-i) precipitation. Although periodontal phenotypes are well documented, pulp/dentin abnormalities have been suggested in the clinical literature although reports are variable and underlying mechanisms remains unclear. in vitro analyses were used to identify mechanisms involved in HPP-associated pulp/dentin phenotypes. Methods: Primary pulp cells cultured from HPP subjects were established to assay alkaline phosphatase (ALP) activity, mineralization, and gene expression compared with cells from healthy controls. Exogenous P-i was provided to the correct P-i/PPi ratio in cell culture. Results: HPP cells exhibited significantly reduced ALP activity (by 50%) and mineral nodule formation (by 60%) compared with the controls. ...
Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF. Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. Am J Surg. 2016 Oct; 212(4):602-608 ...
Oscarvit (OSC) is an in-house preparation consisting of calcium, magnesium, phosphorus, strontium, Vitamin D, and eggshell membrane hydrolysate containing naturally occurring glycosaminoglycans and sulfated glycoproteins. OSC has been used both in an open-label human study and in vitro in osteoblasts. Fifteen patients divided into three groups received oral OSC 0.6 g three times daily for 20 days. The main outcome measures were regional skeletal pain over the treatment period. For the in vitro experiments eight primary human osteoblasts cultures were established from trabecular bone, six of them from the femoral head, and two from the tibia. Cells were cultured for five to 20 days in the presence of 20 μg/ml OSC. Immunocytochemistry and RT-PCR were used to detect molecular alterations involved in the mineralization process. Calcium concentration was measured by means of a colorimetric assay and cell viability was analyzed using the LDH cytotoxicity assay. To investigate whether the osteoblasts response
Looking for arterial mineralization? Find out information about arterial mineralization. 1. of, relating to, or affecting an artery or arteries 2. denoting or relating to the usually bright red reoxygenated blood returning from the lungs or... Explanation of arterial mineralization
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Bone tissue is an organic-inorganic composite material that provides mechanical support and protection for our bodies. Its impressive...
Recent years have seen an increase in the number of studies focusing on alkaline phosphatases (AP), revealing an expanding complexity of function of these enzymes. Of the four human AP proteins, most is known about tissue non-specific AP (TNAP) and intestinal AP (IAP). This review highlights current understanding of TNAP and IAP in relation to human health and disease. TNAP plays a role in multiple processes including bone mineralization, vitamin B6 metabolism and neurogenesis, is the genetic cause of hypophosphatasia, influences inflammation through regulation of purinergic signaling, and has been implicated in Alzheimers disease. IAP regulates fatty acid absorption and has been implicated in the regulation of diet induced obesity and metabolic syndrome. IAP and TNAP can dephosphorylate bacterial derived lipopolysaccharide (LPS), and IAP has been identified as a potential regulator of the composition of the intestinal microbiome, an evolutionarily conserved function. Endogenous and recombinant
Initially recognized by Rathbun in 1948, hypophosphatasia is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a phosphomonoesterase of 507 residues and is anchored at its carboxyl terminus to the plasma membrane by a phosphatidylinositol-glycan ...
Initially recognized by Rathbun in 1948, hypophosphatasia is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a phosphomonoesterase of 507 residues and is anchored at its carboxyl terminus to the plasma membrane by a phosphatidylinositol-glycan ...
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Please email Dr. You at [email protected] if youd like to meet the speaker.. Natural process of mineral formation and dissolution at near-surface conditions are subject to various effects ranging from that of aqueous speciation to biological participation. As such complications arise for laboratory investigations of mineralization and weathering when thermodynamicd is considered the only driving force. Two case studies, one is solution chemistry effect on crystallization and the other microbially mediated dissolution, will be discussed in this presentation to highlight the complexity.. For mineralization, the classical approach states that the net growth rate of mono-molecular layers (ie, step velocity) is determined by the difference between fluxes of species attaching to and detaching from kinks along step edges. Such treatment leads to the development of the widely accepted understanding that step velocity depends solely on solution supersaturation. Yet, literature data from numerous cases argued ...
Wonders of the World specializes in collectible minerals and crystals from all over the world with everything from Aquamarine to Zincite. ...
Download biomineralization medical aspects of solubility.pdf. Free Download with High quality files from our biggest resource. Download PDF, MP3, software, video and more.
TY - JOUR. T1 - Mineralization of nitrogen and sulphur from sheep faeces. AU - Barrow, N.J.. PY - 1961. Y1 - 1961. M3 - Article. VL - 12. SP - 644. EP - 650. JO - Crop & Pasture Science. JF - Crop & Pasture Science. SN - 1836-0947. ER - ...
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Physical Properties of Element Solids, their Compounds and Oxides, and mineral phases at extreme conditions of Pressure and Temprature : an Experimental and theoritical ...