Fig. S1. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the indicated concentrations of CAPE (0-100 μM). The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells were measured by flow cytometry.. Fig. S2. The apoptotic effect of caffeic acid phenethyl ester (CAPE) on stimulated human CD4+ T cells. CD4+ T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and anti-CD28 monoclonal antibodies (2 μg/ml) stimulation. The percentage of annexin-V+ and 7-amino actinomycin D (7-AAD)+ cells from four asthmatic patients were measured by flow cytometry.. Fig. S3. Caffeic acid phenethyl ester (CAPE) inhibits interferon (IFN)-γ and interleukin (IL)-5 production by polarized T helper type 1 (Th1) and Th2 cells. Polarized helper T cells (106 cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 μM) with soluble anti-CD3 and ...
TY - JOUR. T1 - Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. AU - Lin, Hui Ping. AU - Lin, Ching Yu. AU - Huo, Chieh. AU - Hsiao, Ping Hsuan. AU - Su, Liang Cheng. AU - Jiang, Shih Sheng. AU - Chan, Tzu Min. AU - Chang, Chung Ho. AU - Chen, Li Tzong. AU - Kung, Hsing Jien. AU - Wang, Horng Dar. AU - Chuu, Chih Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar colony formation and retarded nude mice xenograft growth of LNCaP 104-R1 cells. We identified that CAPE treatment significantly reduced ...
TY - JOUR. T1 - Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. AU - Wang, L. C.. AU - Chu, K. H.. AU - Liang, Y. C.. AU - Lin, Y. L.. AU - Chiang, B. L.. PY - 2010/5. Y1 - 2010/5. N2 - Summary Caffeic acid phenethyl ester (CAPE), an active component in propolis, is known to have anti-tumour, anti-inflammatory and anti-oxidant properties. In this study, the effects of CAPE on the functions of primary human CD4+ T cells were evaluated in vitro. CAPE significantly suppressed interferon (IFN)-γ and interleukin (IL)-5 production and proliferation of CD4+ T cells stimulated by soluble anti-CD3 and anti-CD28 monoclonal antibodies in both healthy subjects and asthmatic patients. CAPE inhibited nuclear factor (NF)-κB activation and protein kinase B (Akt) phosphorylation, but not p38 mitogen-activated protein kinase (MAPK) phosphorylation in T cells. CAPE also induced active caspase-3 ...
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.. Tolba MF1, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, Mosli HA, Abdel-Rahman SZ, Abdel-Naim AB.. Author information. Abstract. Evidence is growing for the beneficial role of selective estrogen receptor modulators (SERM) in prostate diseases. Caffeic acid phenethyl ester (CAPE) is a promising component of propolis that possesses SERM activity. This study aimed at investigating the modulatory impact of CAPE on docetaxel (DOC) and paclitaxel (PTX) cytotoxicity in prostate cancer cells and exploring the possible underlying mechanisms for this chemomodulation. CAPE significantly increased DOC and PTX potency in PC-3, DU-145 and LNCaP prostate cancer cells. Combination index calculations showed synergistic interaction of CAPE/DOC and CAPE/PTX cotreatments in all the tested cell lines. Subsequent mechanistic studies in PC-3 cells indicated that cyclin D1 and c-myc were significantly ...
BACKGROUND:Our aim was to study the effect of caffeic acid phenethyl ester (CAPE) on iNOS and cystathionine gamma-lyase (CSE) of hepatic fibrosis rat, and discuss the anti-hepatic fibrosis mechanism of caffeic acid phenethyl ester. MATERIAL AND METHODS:We observed changes of NO and H2S in serum of hepatic fibrosis rats. Enzyme-linked immunosorbent assay was used to test OD value of iNOS and CSE in serum of each. The expressions of iNOS and CSE protein in the liver were also detected by immunohistochemistry. RESULTS:Compared with the model group, the expression of NO and iNOS was decreased obviously and the level of H2S and CSE was increased in the CAPE group. CONCLUSIONS:CAPE has the effect of anti-hepatic fibrosis, which can be realized through adjusting the expression level of iNOS and CSE.
In vivo and in vitro antıneoplastic actions of caffeic acid phenethyl ester (CAPE): therapeutic perspectives.. Akyol S1, Ozturk G, Ginis Z, Armutcu F, Yigitoglu MR, Akyol O.. Author information. Abstract. Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-κB at μM concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.. PMID: 23659443 [PubMed - indexed for MEDLINE]. ...
We found that micromolar concentrations of caffeic acid phenethyl ester blocked voltage-gated sodium channel activity in several invasive cell lines from different cancers, including breast (MDA-MB-231 and MDA-MB-468), colon (SW620) and non-small cell lung cancer (H460). In the MDA-MB-231 cell line, which was adopted as a model, long-term (48h) treatment with 18μM caffeic acid phenethyl ester reduced the peak current density by 91% and shifted steady-state inactivation to more hyperpolarized potentials and slowed recovery from inactivation. The effects of long-term treatment were also dose-dependent, 1μM caffeic acid phenethyl ester reducing current density by only 65%. The effects of caffeic acid phenethyl ester on metastatic cell behaviours were tested on the MDA-MB-231 cell line at a working concentration (1μM) that did not affect proliferative activity. Lateral motility and Matrigel invasion were reduced by up to 14% and 51%, respectively. Co-treatment of caffeic acid phenethyl ester ...
Objective(s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has numerous biological effects. In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-β1, TNF-α and prostaglandin E2 (PGE2 ) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF). Materials and Methods: In this study, forty male Sprague-Dawley rats were divided into 5 groups (n=8). (1)
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the anti-inflammatory effects of CAPE on Helicobacter pylori-induced NF-kappaB and AP-1 in the gastric epithelial cell line AGS. Electrophoretic mobility shift assay was used to measure NF-kappaB- and AP-1-DNA binding activity. Western blotting was used to detect IkappaB-alpha and COX-2 expression in AGS cells cocultured with H. pylori. The antiproliferative effect of CAPE was measured by MTT assay. Our results showed that caffeic phenethyl ester inhibits H. pylori-induced NF-kappaB and AP-1 DNA-binding activity in a dose (0.1-25 microg ml(-1) approximately 0.35-88 microM) and time- (15-240 min) dependent manner in AGS cells. Maximum inhibition by CAPE was observed at concentrations of 25 microg ml(-1) ( approximately 88 microM) CAPE prevented H. pylori- and cytokine-induced ...
Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cells. Treatment with CAPE decreased protein abundance of Akt, Akt1, Akt2, Akt3, phospho-Akt Ser473, phospho-Akt Thr 308, GSK3β, FOXO1, FOXO3a, phospho-FOXO1 Thr24, phospho-FoxO3a Thr32, NF-κB, phospho-NF-κB Ser536, Rb, phospho-Rb Ser807/811, Skp2, and cyclin D1, but increased cell cycle inhibitor p27Kip. Overexpression of Akt1 or Akt2 in TW2.6 cells rescued growth inhibition caused by CAPE treatment. Co-treating TW2.6 cells with CAPE and 5-fluorouracil, a commonly used chemotherapeutic drug for oral cancers, exhibited additive cell proliferation inhibition. Our study suggested that administration of CAPE is a
In this Study, it was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE) oil cisplatin hepatotoxicity. Thirty New Zealand rabbits were divided into 5 groups as group 1 (saline-injected control, C), group 2 0% ethanol; vehicle for CAPE, E), group 3 (CAPE), group 4 (cisplatin, CS) and group 5 (cisplatin Plus CAPE, CS + CAPE). Cisplatin caused increased immunoreactivity against inducible nitric oxide synthase (iNOS), but CAPE treatment reduced the immunoreactive hepatocytes. Liver malondialdehide (MDA), nitric oxide (NO(center dot)) levels and xanthine oxidase (XO) activities were higher in CS than in groups C and E. Cisplatin treatment also significantly decreased the tissue reduced glutathione (GSH) concentration compared to groups C and E. CAPE administration normalized the tissue GSH level and XO activity in group CS + CAPE, whereas CAPE treatment did not affect MDA level In group CS + CAPE. In addition, CAPE treatment significantly depressed the cisplatin-induced ...
Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats. ...
CAPE (caffeic acid phenethyl ester) is one of the most valuable and investigated component of propolis which is composed by honeybees. In the current study, we aimed at examining apoptotic effects of CAPE on CCRF-CEM leukemic cells and at determining the roles of mitochondrial membrane potential (MMP) in cell death. ...
Background: To investigate the effects of propofol and caffeic acid phenethyl ester (CAPE) on prevention of lung injury as a remote organ after performing hindlimb ischaemia-reperfusion (IR) in a rat model. ...
Caffeic acid phenethyl ester is Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Cited in 17 publications
To understand the material basis of antitumor activity of Chinese propolis water extract (CPWE), we developed a simple and efficient method using macroporous absorptive resin coupled with preparative high performance liquid chromatography and separated and purified eleven chemical components (caffeic acid, ferulic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) from CPWE; then we tested the antitumor activities of these eleven components using different human tumor cell lines (MCF-7, MDA-MB-231, HeLa, and A549). Furthermore, cell migration, procaspase 3 level, and reactive oxygen species (ROS) of effective components from CPWE were investigated. Our data showed that antitumor activities of the eleven components from CPWE were different from each other. CPWE and its effective components induced apoptosis by inhibiting tumor cell migration, activating caspase 3, and promoting ROS
Vascular endothelial growth factor (VEGF) is a key regulator of pathogenic angiogenesis in diseases such as cancer and diabetic retinopathy. Bee products [royal jelly (RJ), bee pollen, and Chinese red propolis] from the honeybee, Apis mellifera, have been used as traditional health foods for centuries. The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs). In an in vitro tube formation assay, HUVECs and fibroblast cells were incubated for 14 days with VEGF and various concentrations of bee products [RJ, ethanol extract of bee pollen, ethanol extract of Chinese red propolis and its constituent, caffeic acid phenethyl ester (CAPE)]. To clarify the mechanism of in vitro angiogenesis, HUVEC proliferation and migration were induced by VEGF with or without various concentrations of RJ, bee pollen, Chinese red propolis, and CAPE. RJ, bee pollen, Chinese red propolis, and CAPE significantly suppressed VEGF-induced in vitro tube
An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.. Caffeic acid phenethyl ester, or CAPE, is a compound isolated from honeybee hive propolis, the resin used by bees to patch up holes in hives. Propolis has been used for centuries as a natural remedy for conditions ranging from sore throats and allergies to burns and cancer. But the compound has not gained acceptance in the clinic due to scientific questions about its effect on cells.. In a paper published in Cancer Prevention Research, researchers combined traditional cancer research methods with cutting-edge proteomics to find that CAPE arrests early-stage prostate cancer by shutting down the tumor cells system for detecting sources of nutrition.. If you feed CAPE to mice daily, their tumors will stop growing. After several weeks, if you stop the treatment, the tumors will begin to grow ...
Transthyretin (TTR) is a homotetrameric serum protein associated with amyloidoses such as familial amyloid polyneuropathy and senile systemic amyloidosis. The amyloid fibril formation of TTR can be inhibited through stabilization of the TTR tetramer by the binding of small molecules. In this study, we examined the inhibitory potency of caffeic acid phenethyl ester (CAPE) and its derivatives. Thioflavin T assay showed that CAPE suppressed the amyloid fibril formation of TTR. Comparative analysis of the inhibitory potencies revealed that phenethyl ferulate was the most potent among the CAPE derivatives. The binding of phenethyl ferulate and the selected compounds to TTR were confirmed by the 8-anilino-1-naphthalenesulfonic acid displacement and X-ray crystallography. It was also demonstrated that Bio 30, which is a CAPE-rich commercially available New Zealand propolis, inhibited ...
Myeloid differentiation protein 2 (MD2) is an essential molecule which recognizes lipopolysaccharide (LPS), leading to initiation of inflammation through the activation of Toll-like receptor 4 (TLR4) signaling. Caffeic acid phenethyl ester (CAPE) from propolis of honeybee hives could interfere interactions between LPS and the TLR4/MD2 complex, and thereby has promising anti-inflammatory properties. In this study, we designed and synthesized 48 CAPE derivatives and evaluated their anti-inflammatory activities in mouse primary peritoneal macrophages (MPMs) activated by LPS. The most active compound, 10s, was found to bind with MD2 with high affinity, which prevented formation of the LPS/MD2/TLR4 complex. The binding mode of 10s revealed that the major interactions with MD2 were established via two key hydrogen bonds and hydrophobic interactions. Furthermore, 10s showed remarkable protective effects against LPS-caused ALI (acute lung injury) in vivo. Taken together, this work provides new lead ...
SOURCE: Guney M, et al. (2007). Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. 24(2):86-91.. Fluoride is a strong, hard anion and cumulative toxic agent. The effect of fluoride intoxication on lipid peroxidation in endometrial tissue and the protective effects of combinations of vitamins E and C in rats were studied. Additionally, the apoptotic changes in endometrial tissue were examined. Experimental groups were as follows: control group; a group treated with 100 mg/l fluoride (F group); and a group treated with 100 mg/l fluoride plus vitamins E and C (F+Vit group). The F and F+Vit groups were treated orally with fluoride for 30 days. Vitamins E and C were injected simultaneously at doses of 50 mg/kg day i.m. and 20 mg/kg day body weight i.p. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis, was detected with the use of the terminal deoxynucleotidyl ...
The triple-negative breast cancer (TNBC) patients have a high mortality due to paucity of effective treatments. We have utilized human MDA-MB-231 (MDA-231) BC cells, often serving as a model of TNBC, to determine whether CAPE (caffeic acid phenethyl ester), a major medicinal component of propolis, can combat TNBC as a preventive, therapeutic, and/or adjuvant to chemotherapeutic drugs. We found that CAPE inhibits MDA-231 cell growth in vitro and in vivo. In vitro: CAPE dose-dependently inhibits MDA-231 cell growth and has a strong effect on gene and protein expression without affecting non-tumorigenic cells. It inhibits cell proliferation and anti-apoptotic genes, decreases oncogenes, inflammatory cytokines, cyclins, and certain receptors and growth factors (i.e., EGFR, IGFR-like 1&2, RAR, Egr-1, and NF-\#954;B1&2 transcription factors). CAPE also increases p21 and p27. Notably, CAPE down-regulates mdr-1 gene, considered responsible for the resistance of cancer cells to chemotherapeutic agents, ...
Cell Culture and Chemicals. SW1116 cells, a cell line derived from human colon adenocarcinoma, were obtained from American Type Culture Collection (Manassas, VA) and cultured in Leibovitzs L-15 medium containing 10% (v/v) heat-inactivated fetal bovine serum, 100 U/ml penicillin, and 100 μg/ml streptomycin. Chemicals were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise stated. Caffeic acid phenethyl ester (CAPE) was purchased from Calbiochem (San Diego, CA), and celecoxib was a kind gift from SEARLE (Evanston, IL).. Estimation of Cell Viability. Cell viability was assayed by routine 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) reduction method. Briefly, SW1116 cells were seeded into a 96-well plate and incubated for 24 h for attachment. They were then incubated with different drugs for different times at 37°C. At the end of incubation, the medium was aspirated. The remaining cells were further incubated with 0.25 mg/ml MTT for 3 h. MTT was extracted with isopropanol ...
CAPE is an effective inhibitor of NF-kappaB activation in PC-3 cells, but the mechanism of apoptosis, and the corresponding loss of IAP expression, is caspase-dependent.
Dietary polyphenol caffeic acid (1) has been reported for various pharmacological activities. The aim of the current study was to investigate the
The absorption and metabolism in the small intestine of chlorogenic acid (5-O-caffeoylquinic acid), the main phenolic acid in the human diet, and of caffeic acid were studied in rats in order to determine whether chlorogenic acid is directly absorbed
PubMed journal article: Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Download Prime PubMed App to iPhone, iPad, or Android
A novel peroxidase that catalyses the dimerization of ferulic acid or caffeic acid via oxidative coupling and formation of beta beta′-linkage to the lignan-type compounds 8,8′-bis(caffeic acid) or 8,8′-bis(ferulic acid) respectively was purified from the leaves of Bupleurum salicifolium. The enzyme, for which the name caffeate peroxidase is proposed, was purified 2700-fold. It is a glycoprotein and has an Mr of 38,000 as determined by gel filtration and SDS/PAGE. The Km values for ferulic acid and caffeic acid were 0.24 mM and for H2O2 0.04 mM with caffeic acid and 0.48 mM with ferulic acid. The purified peroxidase does not exhibit activity on other phenylpropanoids tested and has no detectable phenol oxidase or NADPH oxidase activity. The caffeate peroxidase could be involved in the biosynthesis of lignans. ...
Cryptococcosis, specifically caused by Cryptococcus neoformans, is a subacute or chronic fungal infection with several manifestations. It is commonly observed as a disseminated disease in the immunocompromised patient with approximately two thirds of patients experiencing meningitis.(3,5) Because of the wide spectrum of Cryptococcosis and the opportunistic nature of such infection, rapid laboratory identification of Cryptococcus neoformans is necessary so that therapy can be immediately initiated. The presumptive identification of Cryptococcus neoformans is based on the presence of an encapsulated yeast (using India ink), the absence of pseudohyphae, the failure to utilize an inorganic nitrate substance, and the ability to produce urease. The final identification of C. neoformans is usually based on typical substrate utilization patterns and brown pigment production in the presence of caffeic acid.(2,3,5). The brown pigmented colonies of Cryptococcus neoformans were observed by Staib in 1962 ...
Material Safety Data Sheet of Caffeic acid contains identification of substance and details of the supplier of the safety data sheet.
In addition to a variety of vitamins and minerals, the glossy purple, red violet, pink or white vegetables are rich in phytochemicals with potent antioxidant effects. For instance, eggplants contain phenolic compounds such as caffeic acid and chlorogenic acid, as well as flavonoids like nasunin. Caffeic acid is a phenol with amazing anti-inflammatory and antioxidant properties that is shown to inhibit cancer cell proliferation. Chlorogenic acid is an amazing hepatoprotective and studies suggest it is incredibly efficient in stopping the multiplication of tumor cells in liver and colon cancers. Other amazing health benefits of chlorogenic acid include antimicrobial, (LDL) cholesterol-lowering and antiviral properties.. The flavonoid called nasunin is mostly found in the skin of the vegetable. Studies focused on the health benefits of nasunin show that it is a powerful antioxidant which efficiently protects cell membranes from the oxidative effects of free radicals. Cell membranes are basically ...
Authors: A.HAKAN AKTAŞ, GÜLSÜM YAŞAR, GÜLEREN ÖZKAN ALSANCAK, ŞAHİNDE DEMİRCİ Abstract: In this study, four hydroxycinnamic acids, namely 3,4-dihydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy --3- methoxycinnamic acid and 4-hydroxy-3,5-dimethoxycinnamic acid, were titrated conductimetrically and potentiometrically using triethylamine and tetrabutylammonium hydroxide in acetonitrile, 2-propanol, and pyridine solvents under a nitrogen atmosphere at 25 ^oC. In conductimetric titration with tetrabutylammonium hydroxide all of the compounds exhibited conventional stoichiometric titration curves in 2-propanol . As is evident from the titration curves, all these compounds gave two well-defined end points. The first end point corresponds to exactly one equivalent and the second one to the two equivalents of the base. In conductimetric titration with tetrabutylammonium hydroxide, all of the acids (except caffeic acid) show two end points in pyridine solvent. These compounds were ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance, instead of having the information ...
In this work, the near-neutral photo-Fenton process, as a means of wastewater disinfection, was enhanced by the addition of Organic Acids (OAs), namely citric, ascorbic, tartaric and caffeic acid. The addition of OAs exhibited significant bacterial inactivation enhancement, compared to the classic photo-Fenton systems (Fe2+/H2O2/solar and Fe3+/H2O2/solar). The improved disinfection performance was not attributed to pH variations by the addition of OAs, but to the increase of the initial dissolved iron in the system, facilitating the Fe3+/Fe2+ turnover in the catalytic photo-Fenton reaction and consequently, the hydroxyl radicals production. For citric and tartaric acid, increased photo-activity of the complexes was associated with their high capability to complex Fe3+ and to promote ligand-to-metal charge transfer (LMCT), which is of key importance to feed Fe2+ to the Fenton process. On the other hand, for ascorbic and caffeic acid, the acceleration of the homogeneous Fenton reaction was ...
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One of the best fragments identified in the previous work was L-tryptophan methyl ester (compound 1), so the researchers naturally tried substituting the methyl group. A phenethyl ester (compound 5c) gave a satisfying 10-fold boost in potency, but this turned out to be the best they could get: shorter or longer linkers were both less active, and modifications around the phenyl ring gave marginal improvements at best. Also, changing the ester to an amide decreased affinity. They were, however, able to improve potency another order of magnitude by acylating the nitrogen (compound 6a ...
Twelve Leuconostoc and seven Weissella strains with extracellular glucansucrase activity were obtained from an analysis of 41 lactic acid bacteria. Culture supernatants of all glucansucrase positive strains catalyzed the glycosylation of caffeic acid with sucrose as donor substrate. Eighteen enzymes produced one major peak, which was identified as caffeic acid-4′-O-α-D-monoglucoside by LC-MS and N ...
Natures Naturals® Propolis is rich in flavonoids, amino acids, and caffeic acid. Propolis has anti-inflammatory and anti-bacterial properties to help fight mild upper respiratory complaints. May help to reduce the severity and duration of the symptoms of colds and flu. It assists with recovery and helps restore good health.. Natures Naturals® Propolis protects and maintains the health of capillaries, Maintain a good blood sugar level, promotes general health and well being.. Natures Naturals® Propolis has an antioxidant property and acts as a free radical scavenger. Free radicals may be generated by lifestyle factors such as dietary fats, cigarette smoke, alcohol consumption, pollutants, and stress.. Directions for use:. Adults only. Take one or two capsules twice daily or as prescribed by your healthcare professional.. WARNING: Propolis may cause allergic reactions. If irritation or swelling of the mouth or throat occurs, discontinue use.. If symptoms persist consult your healthcare ...
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We want to thank all of our valued guests for their support and patience as we, along with the entire Cape May community, navigate the COVID-19 situation. Summer is almost here, and we know many of you are eager to enjoy a much-needed vacation.. As of Friday, June 5, we will begin welcoming guests back to our property. Per guidelines from the City of Cape May, between June 5 and June 22, we will be operating at 60% capacity. After June 22, we plan to open all of our rooms for guests to enjoy.. Our priority, as it has always been, is to maintain safe and responsible operations for everyone who visits and works at The Camelot. In preparation for reopening, we have also been revisiting and enhancing guest experience, as well as cleaning and maintenance protocols to make all of our guests and employees feel as safe and comfortable as possible. We have adopted more rigorous housekeeping procedures aligned to CDC-recommended guidelines and are using EPA approved cleaners and disinfectants. We are also ...
Hawthorns active components are mostly flavonoids (luteolin, apigenin, vitexin, rutin, and quercetin as glycosides) and procyanidins. Hawthorn is also a source of tannins or polyphenols (oligomeric cathechins and epicathechins), carboxylic acids (caffeic acid), triterpenes and simple amines (choline, acetylcholine and tyramine). Researchers were unable to find one major active ingredient. It would seem that the therapeutic effect of Hawthorn, like that of many other herbs, rests on the synergy of all of its components.(1). The various in vivo and in vitro studies have identified many of Hawthorns therapeutic effects:. Increase of cardiac contractility (positive inotropic effect). As a result, heart efficiency and ejection fraction are increased.(2). Peripheral resistance reduction (post-charge reduction). The lesser the resistance, the lesser the effort needed by the heart. The final effect is a reduction in oxygen consumption. (2). Coronary vasodilator (improves heart irrigation and oxygen ...
The Stepford Cuckoos episode allowed Anthony and I to discuss a smidgen of what sibling multiples may or may not go through in their lives. As usual, in no way was this a comprehensive discussion, so I figured a few written words could help flesh out the narrative. Unfortunately (fortunately?) I did a bit of reading on the subject, which led to watching something on the subject, which led to confusion, anger, and a willingness to make an apology for my field for something I didnt do... Im a bit off course. Breathe, doc. Your wife always tells you to breathe. I found out about the Dr. Peter Neubauer study involving the Triplets Pizza Brothers. If that sounds like the corny premise for an evening sitcom, its because I didnt mention the intentional separation of families from infants to study their development into adulthood, keeping everyone in secrecy and the ultimate footnote being one of them committing suicide. But hey! At least they learned what type of women they liked and they
Today I had the best views of Cape May Warblers ever during easily the best day of spring migration so far this year. Birds that had been trapped in the Mid-Atlantic for a week or 10 days finally moved north with heavy migration occurring on southerly winds. New England and northern New York had poor migratory conditions still, stopping a lot of birds when they arrived, and some areas of fog and/or rain also helped locally. I thought these couple of shots were the best I would get, and I was happy enough…. ...
Mental Health, Alcohol and Drug Abuse Board Regular Meeting 2018-02-13T17:00:00. @ William E. Sturm, Jr. Administration Building (County Administration Building), Room G-128, Cape May Court House, New JerseyCape May Court House, New JerseyCape May Court HouseNJ08210 ...
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Chlorogenic acid is an ester of caffeic acid and quinic acid. Chlorogenic acid is the major polyphenolic compound in coffee, isolated from the leaves and fruits of dicotyledonous plants. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal. Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid. The chlorogenic acid content of a 200 ml (7-oz) cup of coffee has been reported to range from 70-350 mg, which would provide about 35-175 mg of caffeic acid. The results of epidemiological research suggest that coffee consumption may help prevent several chronic diseases, including type 2 diabetes mellitus, Parkinsons disease and liver disease (cirrhosis and hepatocellular carcinoma). Most prospective cohort studies have not found coffee consumption to be associated with significantly increased cardiovascular disease risk. However, coffee consumption is associated with increases in several cardiovascular ...
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TY - JOUR. T1 - Stereochemistry of Knoevenagel Condensation Products from Cyanoacetates and Aromatic Aldehydes. AU - Cho, Hidetsura. AU - Iwashita, Takashi. AU - Hamaguchi, Mikiko. AU - Oyama, Yoshiaki. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1991. Y1 - 1991. N2 - The C-13 long-range selective proton decoupling method and X-ray crystallographic analysis were employed to determine the stereochemistry of the caffeic acid derivatives, extremely potent 12-lipoxygenase inhibitors, synthesized from cyanoacetates and aromatic aldehydes. The ester group of 1 and 2 was found to be trans to the phenyl group.. AB - The C-13 long-range selective proton decoupling method and X-ray crystallographic analysis were employed to determine the stereochemistry of the caffeic acid derivatives, extremely potent 12-lipoxygenase inhibitors, synthesized from cyanoacetates and aromatic aldehydes. The ester group of 1 and 2 was found to be trans to the phenyl group.. KW - ...
Umbellic acid (2,4-dihydroxycinnamic acid) is a hydroxycinnamic acid. It is an isomer of caffeic acid. It is a precursor in the umbelliferone biosynthesis pathway. Umbelliferone is a phenylpropanoid and as such is synthesized from L-phenylalanine, which in turn is produced via the shikimate pathway. Phenylalanine is lysated into cinnamic acid, followed by hydroxylation by cinnamate 4-hydroxylase to yield 4-coumaric acid. The 4-coumaric acid is again hydroxylated by cinnamate/coumarate 2-hydroxylase to yield 2,4-dihydroxy-cinnamic acid followed by a bond rotation of the unsaturated bond adjacent to the carboxylic acid group. Finally an intramolecular attack from the hydroxyl group of C2 to the carboxylic acid group closes the ring and forms the lactone umbelliferone. → P A L {\displaystyle {\xrightarrow {PAL}}} → C 4 H {\displaystyle {\xrightarrow {C4H}}} → C 2 H {\displaystyle {\xrightarrow {C2H}}} ⟶ {\displaystyle \longrightarrow } The enzyme 4-hydroxycinnamate decarboxylase, induced ...
To read the authors abstract of the article, click on the title of the article. Then, to read the full article, click on the full text icon. NOTE: Chlorogenic acid and caffeic acid are inhibitors of DNA methylation. Argan oil is a source of chlorogenic acid and caffeic acid. Green coffee bean extract contains chlorogenic […]. View Post ...
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While Jatropha aethiopica, popularly known in Cuba as mata diabetes, is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica, leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (4), a new kaempferol 3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranolsyl-(1→6)]-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2[α-L-rhamnopyranolsyl-(1→6)]-β-D-glucopyranoside (6), rutin (7), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (8) and quercetin (9 ...
A beloved beverage throughout the USA and the world at large, coffee is often blamed for various health woes. While coffee is not appropriate for everyone, and there is such a thing as too much for even the most tolerant of sippers, research has shown a vast array of health benefits.. The abundant phytochemicals found in coffee beans are responsible for the various benefits, including potential prevention of diseases such as Diabetes mellitus type II, Alzheimers disease and even cancer. Of course, we cannot overlook the well-loved stimulant effect of coffee that reliably provides us with increased stamina during exercise, and temporarily improves our cognitive function. Moreover, coffee simply makes mornings tastier.. Following is a brief overview discussing a few of the benefits to coffee consumption. These are presented in defense of coffee and as a thank you to its many active phytochemicals, including caffeine, caffeic acid, hydroxyhydroquine, chlorogenic acid, cafestol and ...
Results: DMEP-A exhibited cytotoxic activity on HN30 cells with significantly decreased viability at 200 μg/ml compared with the control (p , 0.05). However, no significant cytotoxic effect was evident in HN31 cells. DMEP-B and DMEP-C significantly decreased the viability of both cell lines from 100-200 μg/ml and 50-200 μg/ml, respectively (p , 0.05). Interestingly, HN31 cells were more toxically sensitive compared with the HN30 cells when treated with DMEP-B and DMEP-C. IC50 values for DMEP-B with HN30 and HN31 cells were more than 200 μg/ml and 199.8±1.05 μg/ml, respectively. The IC50 of DMEP-C to HN30 and HN31 cells was found to be 114.3±1.29 and 76.33±1.24 μg/ml, respectively. Notably, apigenin, pinocembrin, p-coumaric acid, and caffeic acid were not detected in our propolis extracts ...
Guo, D.J., Chen, F., Inoue, K., Blount, J.W., and Dixon, R.A., 2001, Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa: Impacts on lignin structure and implications for the biosynthesis of G and S lignin, Plant Cell 13:73-88.CrossRefPubMedGoogle Scholar ...
Richard Troum, DO is a Gastroenterologist at 307 Stone Harbor Blvd, Cape May Court House, NJ 08210. Wellness.com provides reviews, contact information, driving directions and the phone number for Cape Atlantic Gastro Assoc in Cape May Court House, NJ.
It is therefore not surprising that attention has focused on identifying small molecule activators of the Nrf2/Keap1 pathway. Many chemically diverse activators have already been identified (6), including the glutathione peroxidase-1 mimetic ebselen (7), sulforaphane found in cruciferous vegetables (8), caffeic acid phenethylester from the bee product propolis (9), cinnamic aldehyde (found in cinnamon bark), and most recently, bardoxolone methyl (10,11). Many have shown promising actions relevant to diabetes complications. For example, activation of Nrf2 by sulforaphane is able to suppress hyperglycemia-induced oxidative stress and metabolic dysfunction in human microvascular endothelial cells (8). A preclinical study by Zheng et al. (12) published in this edition of Diabetes also demonstrates the potential utility of the Nrf2 agonists, sulforaphane and cinnamic aldehyde, for improving the metabolic profile and reducing renal injury in mice with streptozotocin-induced diabetes. Specifically, ...
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Hitching Post (Bourbon Stout) is a American Stout style beer brewed by Cape May Brewing Company in Cape May, NJ. 3.56 average with 4 ratings, reviews and opinions.
In wrinkle formation, caffeic acid and S-allyl cysteine found in garlic significantly inhibited the degradation of type І procollagen and the expressions of MMPs in vivo and attenuated the histological collagen fiber disorder and oxidative stress in vivo, through decreased oxidative stress and inflammation by modulating the activities of NF-κB and AP-1, and exhibited an indirect anti-oxidant effect by suppressing cyclooxygenase-2 (COX-2) and induced nitric oxide synthase (iNOS) expressions levels and down-regulated transcriptional factors(1). Its garlics antioxidant properties may either prevent or delay chronic diseases associated with aging(2). According to Aarhus University, garlic not only protected skin cell from undergo aging process but also inhibited the abnormal growth of skin cells, through its on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts(3 ...
Heres-Pulido, M.E., G. Avila-Acevedo, H. Dionicio-Lopez, G.L.B. Hernandez-Portilla, L. Castaneda-Partida, A.M. Garcia-Bores, G. Martinez-Cortes, S.L. Cardenas, G. Ceron, K. Tavera-Briseno, A. Vargas-Vera, and I.E. Duenas-Garcia. Non toxicity of phenylpropanoid verbascoside from a Buddleja scordioides extract in Drosophila melanogaster flare and Oregon-flare strains and toxicity of caffeic acid in the flare strain ...
Alternative URL: http://www.nature.com/srep/2014/141124/srep07159/full/srep07159.html Abstract: In this work, synergism and antagonism among active ingredients of traditional Chinese medicine (TCM) were studied at system-level by using molecular imprinting technology. Reduning Injection (RDNI), a TCM injection, was widely used to relieve fever caused by viral infection diseases in China. Molecularly imprinted polymers (MIPs) synthesized by sol-gel method were used to separate caffeic acid (CA) and analogues from RDNI without affecting other compounds. It can realize the preparative scale separation. The inhibitory effects of separated samples of RDNI and sample combinations in prostaglandin E2 biosynthesis in lipopolysaccharide-induced RAW264.7 cells were studied. The combination index was calculated to evaluate the synergism and antagonism. We found that components which had different scaffolds can produce synergistic anti-inflammatory effect inside and outside the RDNI. Components which had ...
Horsetail, not to be confused with cat-tail, is possibly the most abundant source of silica in the plant kingdom, so much in fact that the herb can be used for polishing metal. It got the name scouring rush from this very application. The horsetail constitutes one of the most diuretic species in all the plants. That is to say that it possesses a great capacity to eliminate water from the body, in such a point to increase urination up to 30% more than what is habitual. This fact makes that its scientific name Equisetum arvense generally appears in the composition of most of products that habitually are sold to reduce weight. This property is due to the action of several components, among which it is necessary to highlight equisetonin and potassium, but there are another ones that also take part such as calcium, magnesium, ascorbic acid and caffeic acid. ...
Date: Mon, 15 Mar 93 12:00:25 EST From: bszymcz%ulysses at relay.nswc.navy.mil (Bill Szymczak) Subject: re: beer, root beer and cancer In HBD1095 John Sampson brought to our attention a very interesting article appearing in Science, (vol. 258 pg 261) on natural vrs. synthetic carcinogens. The fact that wine and beer were at the top of the list alerted me to read the article myself. In that article Rodent Carcinogens: Setting Priorities, the authors try to support their hypothesis that naturally occuring chemicals have not been as rigorously tested as synthetic chemicals for being potential carcinogens. This was done by using an index (HEPR) measuring the percent of the equivalent (by weight) amount of daily lifetime rat dosage required to halve cancer free rats at the end of a standard lifetime. Some of the values are: HEPR (%) HUMAN EXPOSURE (PER DAY) RAT CARCINOGEN 4.7 Wine (250ml) Ethanol (30 ml) 2.8 Beer (12 oz; 354 ml) Ethanol (18 ml) 0.3 Lettuce, 1/8 head (125 g) Caffeic acid (66.3 mg) ...
Terms of Use Consequently, these pose fewer risks of producing side effects. Even the grapes are a great ally: thanks to the presence of potassium it has a detoxifying action. Keep this in mind if you have a medical condition where you should either add diuretics to your diet or avoid them. They contain flavonoids and caffeic acid that, together with vitamins and minerals, cause a great diuretic effect. Diuretics are also supplied to those attempting to lose weight. Blueberries are a good source of Vitamin K and eating one cup of blueberries provide around 29 micrograms of Vitamin K. Vitamin K is a vital nutrients that plays an important role in keeping us healthy and performs a number of functions in our body, like regulates blood clotting, improving bone density and making our bones stronger, reducing risk of cancer, providing cardiovascular benefits etc . Keep this in mind if you have a medical condition where you should either add diuretics to your diet or avoid them. Artichokes are ...
Each bottle decorated with a unique hand-made tassel.. Our 100% pure Moroccan Argan Oil is extracted through cold pressing that preserves the integrity of the oils fatty acids, vitamins, phenols (including caffeic acid) and carotenes. Argan oils main fatty acid content is made up of oleic acid and linoleic acid. The oil supports healthy skin and reduces blemishes, scarring, eczema, psoriasis, wrinkles and in general keeps the skin healthy.. Add a healthy gloss and strength to your hair.. Try it out as a luxury body oil or primer to foundation!. ...
Sitting or standing for long periods of time can lead to a little more than discomfort. When youre in the same position for long periods, your blood doesnt flow as efficiently as it would with regular movement, this causes the veins to work harder to pump your blood up to your heart. The added effort can lead to the veins becoming swollen and varicose.. Whether youre currently trying to hide protruding veins or find yourself falling into a few of the risk categories above, give Dr. Jeffrey Gosin at Shore Vascular & Vein Center a call at (609) 927-VEIN (8346) for more information, get diagnosed or receive treatments. Dont let the rest of summer pass you by, get out there and show off those legs.. Serving: Cape May County: Cape May, Villas, Marmora, Avalon, Wildwood, Ocean City, West Cape May, North Cape May, Wildwood Crest, Upper Township, Middle Township, Lower Township, Woodbine, Dennis Township; Atlantic County: Somers Point, Northfield, Linwood, Egg Harbor Township, Mays Landing, ...
We caught up with West Virginia-native and our brewhouse driver David Cook, who, although a Pilsner fan himself, says hes stoked to arrive in Cape May.. I dont have to load up again until Friday, so Im excited to try the beer, he told us.. As for the trip thus far? This is what David has to say:. Hows it going? Im getting a lot of attention.. How so? Yesterday, in New Mexico, I thought I was going to be pulled over by the cop behind me, but then I realized he had his phone out, taking pictures. A lot of people are grabbing photos.. Are you taking pictures of your trip? I wanted to in New Mexico, but I couldnt find the really big, really gnarly rocks I was looking for.. Any crazy sightings, wildlife encounters, bizarre happenings en route? All smooth so far.. How many hours are you driving a day? Between 10 and 11.. How are you staying alert? Lots of caffeine.. Is it nerve-wracking driving such a big load? This is my first brew house, but its alright. Its not hanging off the back of the ...
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Book now at The Pier House in Cape May, explore menu, see photos and read 849 reviews: One of my favorite dining spots in Cake May - food is consistently good and service is excellent .
Book now at The Pier House in Cape May, NJ. Explore menu, see photos and read 849 reviews: One of my favorite dining spots in Cake May - food is consistently good and service is excellent .
Cape May, New Jersey, boasts excellent fishing for a variety of species, including blue and white marlin, as well as one of the richest tournaments in the world.
Published in: Proceedings: 2nd Specialized Conference on Pretreatment of Industrial Wastewaters, October 16-18, 1996, Athens, Greece, p. 257-263 ...
The BeagleWire is an FPGA development platform that has been designed for use with BeagleBone boards. BeagleWire is a cape on which there is FPGA device - Lattice iCE40HX. The Lattice iCE40 is a family of FPGAs with a minimalistic architecture and very regular structure, designed for low-cost, high-volume consumer and system applications. The significance of FPGAs is continuously increasing, as they are more and more often used for supporting work of ARM processors. BeagleWire does not require external tools (JTAG) and the whole software is Open Source. iCE40 is an energy saving device, allowing to work with small batteries. FPGA cape allows easy and low cost start for beginners who would like to take their first steps in working with FPGAs. The developed software will be an easy and, at the same time, efficient tool for communication with FPGA. At this point FPGA will be able to meet the requirements of even more advanced applications. The BeagleWire creates a powerful and versatile digital ...
Even though heterogeneities of epithelial and mesenchymal-transitioned cancer cells are often observed within the tumor microenvironment the biological significance of the interaction between epithelial cancer cells and mesenchymal-transitioned cancer cells Salvianolic acid A is not yet understood. mean luminescence?±?SEM. Microarray data analysis The datasets (type:entrez-geo attrs :text:GSE17708″ term_id :17708″GSE17708 and type:entrez-geo attrs :text:GSE23952″ term_id :23952″GSE23952) […]. ...
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Every year, more than half of the honeybee hives in the United States are taken to California to pollinate the state's almond crop. Biologist Laurence
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Chlorogenic acids are among the most abundant phenolics found in the human diet. Of these, the mono-caffeoylquinic acids are the predominant phenolics found in fruits, such as apples and pears, and products derived from ...
Chlorogenic acids are among the most abundant phenolics found in the human diet. Of these, the mono-caffeoylquinic acids are the predominant phenolics found in fruits, such as apples and pears, and products derived from ...
I was wondering if there were any specific regulations regarding how long Maternity must keep placentas that do not meet our hospitals criteria to be sent to the lab for Pathologist evaluation. I am aware of the CLIAA -88 and CAP regulations, but they apply to specimens submitted to the lab. Thank-you for any insight, website, or information you are willing to share, Susan OBrien, Histology Supervisor Burdette Tomlin Memorial Hospital Cape May Court House, NJ _______________________________________________ Histonet mailing list [email protected] http://lists.utsouthwestern.edu/mailman/listinfo/histonet ...