Pathogenic host-microbe interactions can result from continuous evolution of a hosts ability to resist infection and a pathogens ability to survive and replicate. Pseudomonas aeruginosa is a versatile and opportunistic pathogen, ubiquitous in soil, and capable of damaging plants, vertebrates, and invertebrates. Previous studies in nematodes suggest that the pathogenic effects of P. aeruginosa can result from multiple distinct pathways: a toxin-based effect that kills within a few hours and a generalized virulence that kills over the course of multiple days. Using experimental evolution in the highly polymorphic nematode Caenorhabditis remanei, I show that nematode resistance to the two modes of pathogenesis in P. aeruginosa evolves through genetically independent pathways. These results demonstrate that multiple virulence factors in a pathogen can result in multiple responses in the host, and the genetic lines established here create resources for further exploration of the genetic basis for ...
In stark contrast to the wealth of detail about C. elegans developmental biology and molecular genetics, biologists lack basic data for understanding the abundance and distribution of Caenorhabditis species in natural areas that are unperturbed by human influence. Here we report the analysis of dense sampling from a small, remote site in the Amazonian rain forest of the Nouragues Natural Reserve in French Guiana. Sampling of rotting fruits and flowers revealed proliferating populations of Caenorhabditis, with up to three different species co-occurring within a single substrate sample, indicating remarkable overlap of local microhabitats. We isolated six species, representing the highest local species richness for Caenorhabditis encountered to date, including both tropically cosmopolitan and geographically restricted species not previously isolated elsewhere. We also documented the structure of within-species molecular diversity at multiple spatial scales, focusing on 57 C. briggsae isolates from French
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
With the Caenorhabditis briggsae genome now in hand, C. elegans biologists have a powerful new research tool to refine their knowledge of gene function in C. elegans and to study the path of genome evolution.
Despite the prominence of Caenorhabditis elegans as a major developmental and genetic model system, its phylogenetic relationship to its closest relatives has not been resolved. Resolution of these relationships is necessary for studying the steps that underlie life history, genomic, and morphological evolution of this important system. By using data from five different nuclear genes from 10 Caenorhabditis species currently in culture, we find a well resolved phylogeny that reveals three striking patterns in the evolution of this animal group: (i) Hermaphroditism has evolved independently in C. elegans and its close relative Caenorhabditis briggsae; (ii) there is a large degree of intron turnover within Caenorhabditis, and intron losses are much more frequent than intron gains; and (iii) despite the lack of marked morphological diversity, more genetic disparity is present within this one genus than has occurred within all vertebrates. ...
01 Sep 2016 The Blaxter lab website has moved to http://caenorhabditis.org/ 01 July 2015: The Blaxter lab, with support from Edinburgh Genomics, has sequenced 18 further species and launched the Caenorhabditis Genomes Project, see http://caenorhabditis.bio.ed.ac.uk/ There is a BLAST server for the new genome data in Edinburgh and the new raw and preliminary assemblies can be downloaded from the Blaxter lab FTP site ...
A fundamental goal of population genetics is to understand the forces maintaining genetic variation in natural populations. Since different evolutionary processes are expected to have different effects on the genetic variation found within a species, it is possible to use trends in patterns of DNA sequence variation to identify the forces that drive evolution at the molecular level (see Kimura 1983; Li 1997).. For example, studies of Drosophila melanogaster have revealed that genes situated in regions of the genome with greatly reduced rates of recombination (crossing over) are much less variable than genes in regions with normal rates of recombination (Aguadéet al. 1989; Berryet al. 1991; Begun and Aquadro 1991, 1992; Langleyet al. 1993). Subsequent work has shown that this positive correlation between recombination and variation is a characteristic shared by a wide range of taxa, including humans (Nachman 1997, 2001; Dvoráket al. 1998; Kraftet al. 1998; Nachmanet al. 1998; Stephan and ...
Pseudomonas brenneri ATCC ® 49642™ Designation: P17 TypeStrain=False Application: Assay of assimilable organic carbon AOC
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The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics. Lincoln D Stein, Zhirong Bao, Darin Blasiar, Thomas Blumenthal, Michael R Brent, Nansheng Chen, Asif Chinwalla, Laura Clarke, Chris Clee, Avril Coghlan, Alan Coulson, Peter DEustachio, David H. A Fitch, Lucinda A Fulton, Robert E Fulton, Sam Griffiths-Jones, Todd W Harris, LaDeana W Hillier, Ravi Kamath, Patricia E Kuwabara, Elaine R Mardis, Marco A Marra, Tracie L Miner, Patrick Minx, James C Mullikin, Robert W Plumb, Jane Rogers, Jacqueline E Schein, Marc Sohrmann, John Spieth, Jason E Stajich, Chaochun Wei, David Willey, Richard K Wilson, Richard Durbin, Robert H Waterston. Journal article , Research Article , Published 17 Nov 2003 , PLOS Biology ...
WormBase is an online biological database about the biology and genome of the nematode model organism Caenorhabditis elegans and contains information about other related nematodes. WormBase is used by the C. elegans research community both as an information resource and as a place to publish and distribute their results. The database is regularly updated with new versions being released every two months. WormBase is one of the organizations participating in the Generic Model Organism Database (GMOD) project. WormBase comprises the following main data sets: The annotated genomes of Caenorhabditis elegans, Caenorhabditis briggsae, Caenorhabditis remanei, Caenorhabditis brenneri, Caenorhabditis angaria, Pristionchus pacificus, Haemonchus contortus, Meloidogyne hapla, Meloidogyne incognita, Brugia malayi and Onchocerca volvulus; Hand-curated annotations describing the function of ~20,500 C. elegans protein-coding genes and ~16,000 C. elegans non-coding genes; Gene families; Orthologies; Genomic ...
Inbreeding depression is the reduced biological fitness in a given population as a result of inbreeding, or breeding of related individuals. Population biological fitness refers to an organisms ability to survive and perpetuate its genetic material. Inbreeding depression is often the result of a population bottleneck. In general, the higher the genetic variation or gene pool within a breeding population, the less likely it is to suffer from inbreeding depression. Inbreeding depression seems to be present in most groups of organisms, but varies across mating systems. Hermaphroditic species often exhibit lower degrees of inbreeding depression than outcrossing species, as repeated generations of selfing is thought to purge deleterious alleles from populations. For example, the outcrossing nematode (roundworm) Caenorhabditis remanei has been demonstrated to suffer severely from inbreeding depression, unlike its hermaphroditic relative C. elegans, which experiences outbreeding depression. Inbreeding ...
The TALEN approach works in C. briggsae Lo et al. 2013,Wood et al. 2011, Wei et al. 2013. The CRISPR/Cas9 method is now implemented in C. briggsae and other species. Using the same plasmids as in C. elegans is possible, at least in C. briggsae: see Culp et al. in biorxiv. Using Cas9 protein and synthetic guide RNA may overcome problems of germ line silencing and of inadequate promoters or 3UTR in other species. See Witte et al. 2015 in Pristionchus pacificus. This method has been successfully used in several Caenorhabditis species (Marie Delattre). ...
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003 ...
The wormbase gene report ( http://www.wormbase.org/db/gene/allele?name=e996;class=Allele ) suggests there are several other alleles for this gene with Jonathon Hodgkin as the contact see http://www.wormbase.org/db/misc/etree?name=CB;class=Laboratory Anthony m.larsen wrote: , I am working on sup-1 and was wondering if anyone has other alleles ,than e995. , In particular I would be interested in the x-ray induced e995xri. The , reference allele e995 is the only allele available from the CGC, so if anyone , would be able to provide me with additional sup-1 alleles I would be very , greatful. , , Thank you , , Morten K. Larsen , University of Southern Denmark , DK , m.larsen at bmb.sdu.dk , , --- ...
OpenLink Virtuoso version 07.20.3215 as of Jan 18 2016, on Linux (x86_64-unknown-linux-gnu), Single-Server Edition (15 GB total memory ...
Directory. Start here to access encyclopedic information about the worm genome and its genes, proteins, and other encoded features… Find out more. ...
Visit our Bristol store located on the historical Corn Street, near to the Floating Harbour, in the heart of Bristols market centre. The branch was our first to launch outside of London and the doors were opened in 1997 by the great travel writer Eric Newby. When youre in store, look out for our impressive map of Bristol at 1:5,000 scale, covering the entire staircase wall from the ground floor to the basement. ...
On 17 November join TEDxBristol for Reflect. Rethink. Reboot - a day of live inspirational talks and activities focused on not just surviving, but thriving in
Cambria: Cambria, county, central Pennsylvania, U.S. It consists of a mountainous region on the Allegheny Plateau, with the Allegheny Mountains along the eastern edge. The principal waterways are the Conemaugh and Little Conemaugh rivers, Glendale Lake, and Beaverdam Run, in addition to Clearfield, Stony,
Mouse mAb M38 was used in indirect immunofluorescence experiments to detect a stage-specific antigen on the surface of the first larval stage (L1) of the free-living nematode Caenorhabditis elegans, and to detect alterations in the apparent expression of this antigen in two distinct classes of C. elegans mutants. In previously described srf-2 and srf-3 mutants (Politz S. M., M. T. Philipp, M. Estevez, P.J. OBrien, and K. J. Chin. 1990. Proc. Natl. Acad. Sci. USA. 87:2901-2905), the antigen is not detected on the surface of any stage. Conversely, in srf-(yj43) and other similar mutants, the antigen is expressed on the surface of the first through the fourth (L4) larval stages. To understand the molecular basis of these alterations, the antigen was characterized in gel immunoblotting experiments. After SDS-PAGE separation and transfer to nitrocellulose, M38 detected a protein antigen in extracts of wild-type L1 populations. The antigen was sensitive to digestion by Pronase and O-glycanase ...
Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow one to screen for mutations that disrupt the specification or function of those neurons. We identified serotonin-immunoreactive neurons required for tail curling or turnin …
Lysosomes are one of the major degradative organelles in eukaryotic cells that carry out diverse cellular functions. Lysosomes show highly dynamic behaviors, including homotypic and heterotypic fusions, fission, and formation/reformation, which itself involves budding, extension, and scission. We carried out an unbiased forward mutational screen to identify novel regulators of lysosome dynamics and/or function; this screen is based on the degradation of a substrate, GFP, that is endocytosed by scavenger cells in worms. We identified cup-5 and six additional proteins that have lysosomal functions in C. elegans coelomocytes. CUP-16 is only conserved in the genus Caenorhabditis, and likely functions in endocytic uptake at the plasma membrane and in lysosomal degradation. Besides CUP-16, five of the mammalian homologs of the other CUP proteins, CIC-7, OSTM1, PLEKHM1, Cystinosin, and TRPML1, had been previously implicated in lysosome biology, thus validating this approach (Bach 2001; Lange et al. ...
Independent reversions of mutations affecting three different Caenorhabditis elegans genes have each yielded representatives of the same set of extragenic suppressors. Mutations at any one of six loci act as allele-specific recessive suppressors of certain allels of unc-54 (a myosin heavy chain gene), lin-29 (a heterochronic gene), and tra-2 (a sex determination gene). The same mutations also suppress certain alleles of another sex determination gene, tra-1, and of a morphogenetic gene, dpy-5. In addition to their suppression phenotype, the suppressor mutations cause abnormal morphogenesis of the male bursa and the hermaphrodite vulva. We name these genes smg-1 through smg-6 (suppressor with morphogenetic effect on genitalia), in order to distinguish them from mab (male abnormal) genes that can mutate to produce abnormal genitalia but which do not act as suppressors (smg-1 and smg-2 are new names for two previously described genes, mab-1 and mab-11). The patterns of suppression, and the ...
We describe a new type of collective behavior in C. elegans nematodes, aggregation of starved L1 larvae. Shortly after hatching in the absence of food, L1 larvae arrest their development and disperse in search for food. In contrast, after two or more days without food, the worms change their behavior-they start to aggregate. The aggregation requires a small amount of ethanol or acetate in the environment. In the case of ethanol, it has to be metabolized, which requires functional alcohol dehydrogenase sodh-1. The resulting acetate is used in de novo fatty acid synthesis, and some of the newly made fatty acids are then derivatized to glycerophosphoethanolamides and released into the surrounding medium. We examined several other Caenorhabditis species and found an apparent correlation between propensity of starved L1s to aggregate and density dependence of their survival in starvation. Aggregation locally concentrates worms and may help the larvae to survive long starvation. This work demonstrates how
During the course of normal embryonic and post-embryonic development, 131 cells in a Caenorhabditis elegans hermaphrodite undergo programmed cell death. Loss of function mutations in either of the genes ced-3 or ced-4 abolish cell deaths, enabling these undead cells to survive and be incorporated into the adult with no obvious deleterious consequences. Ultrastructural reconstructions have shown that undead cells exhibit many differentiated characteristics. Most of the reconstructed cells appeared to be neurons with all the characteristic features associated with such cells, such as processes, synaptic vesicles and presynaptic specializations. However, clear morphological differences were seen among the undead neurons, suggesting a diversity of cell type. One of the reconstructed cells was a rectal epithelial cell, which had displaced its lineal sister that normally functions in this role. Removal of the ability to undergo programmed cell death by mutation therefore reveals a diversity of ...
A specific behavioural response of Caenorhabditis elegans, the rapid increase of locomotion in response to anoxia/reoxygenation called the O2-ON response, has been used to model key aspects of ischaemia/reperfusion injury. A genetic suppressor screen demonstrated a direct causal role of CYP (cytochrome P450)-13A12 in this response and suggested that CYP-eicosanoids, which in mammals influence the contractility of cardiomyocytes and vascular smooth muscle cells, might function in C. elegans as specific regulators of the body muscle cell activity. In the present study we show that co-expression of CYP-13A12 with the NADPH-CYP-reductase EMB-8 in insect cells resulted in the reconstitution of an active microsomal mono-oxygenase system that metabolized EPA (eicosapentaenoic acid) and also AA (arachidonic acid) to specific sets of regioisomeric epoxy and hydroxy derivatives. The main products included 17,18-EEQ (17,18-epoxyeicosatetraenoic acid) from EPA and 14,15-EET (14,15-epoxyeicosatrienoic acid) ...
New release of WormBase WS223, Wormpep223 and Wormrna223 Mon Jan 24 12:12:08 GMT 2011 WS223 was built by Paul Davis -===================================================================================- The WS223 build directory includes: genomes DIR - contains a sub dir for each WormBase species with sequence, gff, and agp data genomes/b_malayi: - genome_feature_tables/ sequences/ genomes/c_brenneri: - genome_feature_tables/ sequences/ genomes/c_briggsae: - genome_feature_tables/ sequences/ genomes/c_elegans: - annotation/ genome_feature_tables/ sequences/ genomes/c_japonica: - genome_feature_tables/ sequences/ genomes/c_remanei: - genome_feature_tables/ sequences/ genomes/h_bacteriophora: - genome_feature_tables/ sequences/ genomes/h_contortus: - genome_feature_tables/ sequences/ genomes/m_hapla: - genome_feature_tables/ sequences/ genomes/m_incognita: - sequences/ genomes/p_pacificus: - genome_feature_tables/ sequences/ *annotation/ - contains additional annotations i) confirmed_genes.WS223.gz ...
We think we have a good candidate in the form of a small nematode worm, Caenorhabditis briggsae, which has the following properties. It is a self-fertilizing hermaphrodite, and sexual propagation is therefore independent of population size. Males are also found (0.1%), which can fertilize the hermaphrodites, allowing stocks to be constructed by genetic crosses. Each worm lays up to 200 eggs which hatch in buffer in twelve hours, producing larvae 80 microns in length. These larvae grow to a length of 1 mm in three and a half days, and reach sexual maturity. However, there is no increase in cell number, only in cell mass. The number of nuclei becomes constant at a late stage in development, and divisions occur only in the germ line. Although the total number of cells is only about a thousand, the organism is differentiated and has an epidermis, intestine, excretory system, nerve and muscle cells. Reports in the literature describe the approximate number of cells as follows: 200 cells in the gut, ...
Caenorhabditis elegans MIG-13 protein: required for positioning of Q neuroblasts and their descendents along the anteroposterior axis; isolated from Caenorhabditis elegans; amino acid sequence in first source; GenBAnk AF150958
Fig. 27 - Longitudinal section taken near the midline showing a sagittal view of the ventral muscle plate (region enclosed by arrows, MP). The most obvious deviation from a purely commisural nature of the ring occurs in its participation in the integration of sensory input and cephalic muscle motor output. Primary input is effected by synapses formed by the posterior processes of the bipolar papillary neurons whose cell hody locations have been described. The entry of these fibers into the ring is shown in the three parts of figure 28. In figure 28A the subdorsal papillary fibers are grouped as a bundle outside of the circumferential fibers of the nerve ring, but nonetheless within the thin glial sheath formed by the four LSM pocket cell bodies. In figure 28B at the posterior edge of the ring they are seen to turn from a longitudinal to a radial dIrection and plunge into the center of the circumferential fibers. At the level of figure 28C, taken anterior to figure 28A, all fibers except for ...
Pun, P.B.L., Gruber, J., Tang, S.Y., Ng, L.F., Cheah, I., Halliwell, B., Ong, R.L.S., Fong, S. (2010). Ageing in nematodes: Do antioxidants extend lifespan in Caenorhabditis elegans?. Biogerontology 11 (1) : 17-30. [email protected] Repository. https://doi.org/10.1007/s10522-009-9223- ...
Abstract. Studies of the molecular mechanisms that are involved in stress responses (environmental or physiological) have long been used to make links to disease states in humans. The nematode model organism, Caenorhabditis elegans, undergoes a state of hypometabolism called the dauer stage. This period of developmental arrest is characterized by a significant reduction in metabolic rate, triggered by ambient temperature increase and restricted oxygen/ nutrients. C. elegans employs a number of signal transduction cascades in order to adapt to these unfavourable conditions and survive for long times with severely reduced energy production. The suppression of cellular metabolism, providing energetic homeostasis, is critical to the survival of nematodes through the dauer period. This transition displays molecular mechanisms that are fundamental to control of hypometabolism across the animal kingdom. In general, mammalian systems are highly inelastic to environmental stresses (such as extreme ...
gi,17559712,ref,NP_506256.1, CaDHerin family member (cdh-6) [Caenorhabditis elegans] gi,7499172,pir,,T20968 hypothetical protein F15B9.7 - Caenorhabditis elegans gi,3875964,emb,CAB01427.1, Hypothetical protein F15B9.7 [Caenorhabditis elegans] gi,3880568,emb,CAB01449.1, C. elegans CDH-6 protein (corresponding sequence F15B9.7) [Caenorhabditis elegans ...
I am not one to give in to the insolence of those brutes. I think the planets are worlds revolving around the sun and that the fixed stars are also suns that have planets revolving around them. We cant see those worlds from here because they are so small and because the light they reflect cannot reach us. How can one honestly think that such spacious globes are only large, deserted fields? And that our world was made to lord it over all of them just because a dozen or so vain wretches like us happen to be crawling around on it? Do people really think that because the sun gives us light every day and year, it was made only to keep us from bumping into walls? No, no, this visible god gives light to man by accident, as a kings torch accidentally shines upon a working man or burglar passing in the street. ...
Directed by Fernand Rivers. With Claude Dauphin, Ellen Bernsen, Pierre Bertin, Christian Bertola. Long-nosed Cyrano de Begerac helps an army officer woo Roxanne, the woman he loves.
A mutation in the let-653 gene of Caenorhabditis elegansresults in larval death. The lethal arrest is concurrent with the appearance of a vacuole anterior to the lower pharyngeal bulb. The position...
Working with starved L1 larvae of C. elegans and C. briggsae we noticed that these two species behave quite differently in starvation. First, C. elegans adults stop laying eggs after exhausting bacterial food, which eventually leads to internal hatching and bagging. C. briggsae do not show this behavior. This difference has been observed before (McCulloch and Gems, 2003). Second, at high enough density of worms, arrested C. elegans L1s aggregate on agar plates after several days of starvation (Fig. 1a). C. briggsae L1s do not form aggregates (Fig. 1b). Aggregation may serve several purposes ranging from decrease of surface to volume ratio and use of diffusible "public goods" to sharing information about quality of the environment. Third, survival of starved C. elegans L1s strongly depends on their density - the higher the worm density, the longer they survive (Fig. 1c) (Artyukhin et al., 2013). This holds true for starvation on plates as well as in suspension. Survival of C. briggsae L1s is ...
The main focus of our research is the study of neuronal function and dysfunction, using the nematode Caenorhabditis elegans as a model organism. Among...
The let-7 miRNA was originally discovered in the nematode Caenorhabditis elegans, where it regulates cell proliferation and differentiation, but subsequent work has shown that both its sequence and its function are highly conserved in mammals ...
Next-day shipping cDNA ORF clones derived from nck-1 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family available at GenScript, starting from $99.00.
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Pill with imprint BRISTOL 7279 BRISTOL 7279 is Maroon & Pink, Capsule-shape and has been identified as Trimox 500 mg. It is supplied by Sandoz Pharmaceuticals Inc..
Nematocida parisii ATCC ® PRA-289™ Designation: ERTm1 Isolation: Wild-caught Caenorhabditis elegans isolated from a compost pit, Franconville, France ref
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1. Baldwin, J.G., Nadler, S.A., and Wall, D.H. 1997. Nematodes: Pervading the Earth and Linking all Life. Pp. 176-191. In: Raven, P.H. (ed.). National Academy Press, Washington, D.C. 625 pp.. 2. Bargmann, C. I. 1998. Neurobiology of the Caenorhabditis elegans genome. Science 282:2028-2033.. 3. Bargmann, C. I. And Mori, I. 1997. Chemotaxis and Thermotaxis. Pp. 717-737. In: Riddle, D.L., Blumenthal, T., Meyer, B.J. and Priess, J.R. (eds). C. elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY 1222 pp.. 4. Bird, D.M. and Opperman, C. H. 1998. Caenorhabditis elegans. J. Nematol. 30:299-308.. 5. Bird, D.M., Opperman, C.H., Jones S.J.M., and Baillie, D.L. 1999. The Caenorhabditis elegans gemome: a guide in the post genomics age. Annu. Rev. Phytopathol. 37:247-265.. 6. Blaxter, M. 1998. Caenorhabditis elegans is a nematode. Science 282:2041-2046.. 7. Blaxter, M. and Bird, D. 1997. Parasitic nematodes. Pp. 851-878. In: Riddle, D.L., Blumenthal, T., Meyer, B.J. and Priess, J.R. (eds). C. ...
Normal locomotion of the nematode Caenorhabditis elegans requires transmission of contractile force through a series of mechanical linkages from the myofibrillar lattice of the body wall muscles, across an intervening extracellular matrix and epithel
Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. wRBP1.0 will provide a