TY - JOUR. T1 - Pre‐pregnancy body mass index is associated with dietary inflammatory index and C‐reactive protein concentrations during pregnancy. AU - Shin, Dayeon. AU - Hur, Junguk. AU - Cho, Eun Hee. AU - Chung, Hae Kyung. AU - Shivappa, Nitin. AU - Wirth, Michael D.. AU - Hébert, James R.. AU - Lee, Kyung Won. PY - 2017/4/1. Y1 - 2017/4/1. N2 - There have been a limited number of studies examining the association between prepregnancy body mass index (BMI) and dietary inflammation during pregnancy. Our aim is to examine the association between pre‐pregnancy BMI and the Dietary Inflammatory Index (DII)™ and C‐reactive protein (CRP) concentrations during pregnancy. The study included 631 pregnant American women from the National Health and Nutrition Examination Survey (NHANES) crosssectional examinations from 2003 to 2012. Pre‐pregnancy BMI was calculated based on self‐reported pre‐pregnancy weight and measured height. The cut‐offs of ,18.5 (underweight), 18.5-24.9 (normal), ...
Using a prospective cohort study of 2,910 Danish women with invasive breast cancer, we have demonstrated that elevated CRP levels at the time of diagnosis of breast cancer were associated with reduced overall and disease-free survival and with increased risk of death from breast cancer. These are novel observations.. Mechanistically, three components might explain the observed association between elevated CRP levels and poor breast cancer prognosis. First, tumour cell behavior: plasma CRP levels may reflect the aggressiveness of the tumour, that is, plasma CRP levels might sum up some prognostic information of well-known tumour characteristics, such as tumour stage and grade. In the present study, elevated CRP levels were indeed associated with larger tumour size, presence of distant metastases, and lower tumour grade (although CRP was not linearly associated with tumour grade), and these prognostic factors were associated with poor prognosis. Second, adjacent inflammation: plasma CRP levels ...
Background. Cardiac Magnetic Resonance Imaging (CMR) can identify myocardial damage due to embolization after percutaneous coronary interventions (PCI). Late Gadolinium Enhancement (LGE) can non-invasively detect myocardial fibrosis however the association of High sensitive C-reactive protein (HS-CRP) or Neopterin levels with myocardial damage in PCI is currently unknown.. Methods. Patients admitted with potential PCI were enrolled. LGE CMR scan was performed 24hours pre- and 24 hours post-PCI. Fourty five patients were enrolled, 61±12 yrs old, 33(73%) male. CMR performed pre PCI failed to show LGE in the area of the target vessel. TnI were not elevated at baseline. New LGE areas in the 2nd CMR scan were classified in distal (, 10 mm downstream from the stent) or adjacent (close to the stent). Troponin I was assessed at baseline and at 12 and 24 hours after PCI.. Results. In 35 out of 45 pts, baseline levels of HS-CRP and neopterin were measured.Troponin I elevation occurred in 26 (58%) ...
The results of the present study demonstrate for the first time that elevated CRP levels are associated with a profound impairment in systemic endothelial vascular reactivity in patients with coronary artery disease. The blunted systemic endothelial vasodilator function related to elevated plasma CRP levels is independent of classic risk factors for coronary artery disease. Most importantly, normalization of CRP levels over time is associated with a significant improvement in endothelium-dependent FBF responses. These findings support the concept that alterations in endothelial cell function may provide a link between systemic inflammation and ischemic coronary events.. It is well established that atherosclerosis impairs endothelial vasodilator function in both the coronary18 and the forearm circulation. Moreover, chronic risk factors for coronary artery disease have been shown to adversely affect endothelium-dependent blood flow responses in the human forearm circulation.19 20 However, the ...
TY - JOUR. T1 - Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting. AU - Hong, Young Joon. AU - Jeong, Myung Ho. AU - Lim, Sang Yeob. AU - Lee, Sang Rok. AU - Hong, Seo Na. AU - Kim, Kye Hun. AU - Sohn, Il Suk. AU - Park, Hyung Wook. AU - Kim, Ju Han. AU - Kim, Weon. AU - Ahn, Youngkeun. AU - Cho, Jeong Gwan. AU - Park, Jong Chun. AU - Kang, Jung Chaee. PY - 2006/8/1. Y1 - 2006/8/1. N2 - Although various predictors relating to in-stent restenosis (ISR) have been demonstrated, the relation between the parameters of intravascular ultrasound and inflammatory markers and ISR has not been reported. This study included 120 patients who underwent stent implantation for angiographically significant stenosis. Patients were divided into a soft plaque group (n = 50) and a nonsoft plaque group (n = 70). All patients underwent angiographic and intravascular ultrasound follow-up at 6 ...
Two cross-sectional studies of adults showed no association between CRP levels and carotid intima-medial thickness (IMT) measured by ultrasound.21,22 Two other studies found no association between serum CRP and coronary artery calcification.23,24 The Framingham Study found an association between CRP and internal carotid IMT (but not common carotid IMT) only in women.25. CRP levels were higher in subjects dying with, but not resulting from, severe coronary atherosclerosis, and were also higher in subjects dying because of recent coronary thrombosis without infarction, than in subjects dying from noncardiovascular causes with minimal coronary atherosclerosis.26 Immune reactivity to heat shock proteins, but not CRP concentration, was associated with carotid and femoral IMT in young (17 to 18 years) men.27 Human transgene expression accelerated aortic atherosclerosis in apolipoprotein E-deficient mice.28. The AHA classification system is based on a temporal sequence that is deduced from lesions ...
BackgroundInflammation and microvascular dysfunction (MVD) are independently associated with adverse cardiovascular outcomes in patients with ischaemic heart disease. This study aimed to assess the relationship between inflammation, MVD and myocardial injury.MethodsCoronary microvascular function was assessed in 74 patients undergoing percutaneous coronary intervention (PCI) using the index of microvascular resistance (IMR) by a pressure-temperature sensor-tipped wire. Serum high-sensitivity C-reactive protein (hsCRP) level was quantified by rate turbidimetry. Severe MVD was defined as IMR|30. Pearson correlation was computed to assess the relationships between hsCRP, troponin and IMR of culprit vessel. Predictors of severe MVD were assessed by regression analysis. ResultsAcute coronary syndromes (ACS) represented 49% of the total cohort. Study cohort was divided into Low CRP (hsCRP3mg/L) groups. There was higher representation of smokers (78% vs. 52%), diabetics (39% vs. 18%) and ACS (61% vs. 33%), as
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
The high sensitivity C-reactive protein (hs-CRP), mediator of atherosclerotic disease, is known to be a sensitive predictor of coronary heart disease in type 2 diabetes mellitus (T2DM).. Aims: To evaluate the relationship of hs-CRP levels to metabolic syndrome (MS) and albuminuria in T2DM.. Methods: Four hundred and eighty-eight T2DM subjects were recruited. Patients with hs-CRP ≥10 mg/l, creatinine ≥1.4 mg/dl, chronic inflammatory and cardiovascular diseases, smokers or on antiplatelet therapy were excluded. In all the 178 subjects (65.2±10.7 years, 71 men and 107 women) enrolled, we measured hs-CRP, waist circumference (WC), fasting plasma glucose (FPG), systolic and diastolic blood pressure, high density lipoprotein-cholesterol (HDL-Ch), triglycerides (TGs), and 24 h. Albumin excretion (ALB-e). The MS was defined according to the IDF criteria. Student s t-test was used to compare the means, and the Mann Whitney U test to analyze the relationship between hs-CRP levels and the presence of ...
The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin (P for trend = .007), pyridoxine (P for trend = .042), and cobalamin (P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin (P for trend = .084) and pyridoxine (P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile.. CONCLUSION ...
Lupus and elevated c reactive protein levels - Whatcauses high c-reactive protein ihave IBS andfamily history of lupus could either of these be the cause? CRP. Is just a marker for inflammation whatever the cause.
C-reactive protein is a sensitive but nonspecific systemic marker of inflammation. Several prospective studies have investigated the association of prediagnostic circulating C-reactive protein concentrations with the development of colorectal cancer, but the results have been inconsistent. We performed a systematic review of prospective studies of the association between prediagnostic measurements of circulating high-sensitivity C-reactive protein and development of invasive colorectal cancer. Authors of original studies were contacted to acquire uniform data. We combined relative risks (RR) for colorectal cancer associated with a one unit change in natural logarithm-transformed high-sensitivity C-reactive protein using inverse variance weighted random effects models. We identified eight eligible studies, which included 1,159 colorectal cancer cases and 37,986 controls. The summary RR per one unit change in natural log-transformed high-sensitivity C-reactive protein was 1.12 (95% confidence intervals
TY - JOUR. T1 - Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial. AU - Soedamah-Muthu, S.S.. AU - Livingstone, Shona J.. AU - Charlton-menys, Valentine. AU - Betteridge, D. John. AU - Hitman, Graham A.. AU - Neil, H. Andrew W.. AU - Bao, Weihang. AU - Demicco, David A.. AU - Preston, Gregory M.. AU - Fuller, John H.. AU - Stehouwer, Coen D. A.. AU - Schalkwijk, Casper G.. AU - Durrington, Paul N.. AU - Colhoun, Helen M.. PY - 2015/7/1. Y1 - 2015/7/1. U2 - 10.1007/s00125-015-3586-8. DO - 10.1007/s00125-015-3586-8. M3 - Article. VL - 58. SP - 1494. EP - 1502. JO - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. JF - Diabetologia: Clinical and experimental diabetes and metabolism: Organ of the European Association for the Study of Diabetes. SN - 0012-186X. IS - 7. ER - ...
C-reactive protein has been used to identify patients at high risk for infectious morbidity with preterm labor or preterm rupture of membranes. In this article we report on 104 patients with preterm labor symptoms (n = 45) or preterm rupture of the membranes (n = 59) and serial evaluations of C-reactive protein measured by latex agglutination and laser nephelometry. The simple, inexpensive latex method appears comparable to the laser method in predicting infectious morbidity and can be used clinically. Elevated C-reactive protein values before delivery predict infectious morbidity in only 8% to 29% of patients, and up to 18% of patients with serious infections may be misdiagnosed as having normal C-reactive protein values before delivery.
Kovacs, A, Green, F, Hansson, LO, Lundman, P, Samnegard, A, Boquist, S, Ericsson, CG, Watkins, HH, Hamsten, A and Tornvall, P (2005) A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein ...
Background and Purpose- Recent studies described an association between elevated levels of C-reactive protein (CRP) and outcome after ischemic stroke. We investigated the impact of early serial CRP measurements in hyperacute ischemic stroke on long-term outcome.. Methods- One hundred twenty-seven consecutive patients without thrombolysis with a first ischemic stroke no more than 12 hours after symptom onset were examined. Serial CRP measurements were done at admission (CRP 1), within 24 hours (CRP 2), and within 48 hours (CRP 3) after symptom onset. In addition to several cerebrovascular risk factors, the 1-year outcome and the lesion volumes of initial diffusion-weighted images were determined.. Results- The CRP concentration increased significantly during the first 48 hours after symptom onset (CRP 1, 0.86 mg/dL [95% CI, 0.69 to 1.02]; CRP 2, 1.22 mg/dL [95% CI, 0.88 to 1.55]; CRP 3, 1.75 mg/dL [95% CI, 1.25 to 2.25]; P=0.003). Multiple logistic regression analysis identified Barthel Index ...
Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients - Volume 101 Issue 8 - An Pan, Wendy Demark-Wahnefried, Xingwang Ye, Zhijie Yu, Huaixing Li, Qibin Qi, Jianqin Sun, Yanqiu Chen, Xiafei Chen, Yong Liu, Xu Lin
Serum concentrations of CRP increase several hundredfold in response to bacterial infection, making it an attractive diagnostic test for neonatal sepsis. Because many of the more than 70 publications on this subject that have appeared during the past 30 years were flawed by imprecise diagnostic criteria, absent or inappropriate controls (eg, healthy neonates), incomplete description of results, or inadequate sample sizes, the role of this test in evaluation of neonates remains controversial. Early reports described a high prevalence of elevated CRP levels in infected infants, but levels are elevated in only 35% to 65% of neonates with bacterial infection at the onset of illness. Recognition that a delay of at least several hours is intrinsic to the cascade of events leading to elevation of serum CRP levels (including activation of neutrophils, elaboration of interleukin-6, and induction of hepatic synthesis of CRP) led to appropriate criticism of this test as having insufficient sensitivity to ...
As an acute-phase protein, human C-reactive protein (CRP) is clinically important. CRPs were purified from several samples in six different pathological conditions, where their levels ranged from 22 to 342 μg/ml. Small, but significant, variations in electrophoretic mobilities on native PAGE suggested differences in molecular mass, charge and/or shape. Following separation by SDS/PAGE, they showed single subunits with some differences in their molecular masses ranging between 27 and 30.5 kDa, but for a particular disease, the mobility was the same for CRPs purified from multiple individuals or pooled sera. Isoelectric focusing (IEF) also indicated that the purified CRPs differed from each other. Glycosylation was demonstrated in these purified CRPs by Digoxigenin kits, neuraminidase treatment and binding with lectins. The presence of N-linked sugar moiety was confirmed by N-glycosidase F digestion. The presence of sialic acid, glucose, galactose and mannose has been demonstrated by gas liquid ...
(2014) Magro et al. Journal of Crohns and Colitis. Background: Infliximab (IFX) is effective in treating Crohns disease (CD) and C-reactive protein (CRP) is a useful biomarker in assessing inflammatory activity. Aim: Correlate CRP levels before beginning of IFX, at week 14 and CRP delta within ...
C-reactive protein (CRP) is an acute-phase reactant frequently used in histochemistry like a marker of ongoing inflammation. [AA] 218 to 232) was identified by CP-724714 monoclonal antibodies CRP-8 and 9C9. This epitope region of Hsp60 displays 26.6% amino acid identity to CRP AA region 77 to 90. These data suggest that the B-cell epitopes shared between CRP and Hsp60 give rise to a true mimicry-based cross-reaction and the induction of cross-reactive antibodies. Our study underlines the importance of thorough study design and careful interpretation of results while using polyclonal anti-CRP antibodies for histochemistry, especially at low dilutions. Furthermore, analytical interference with Hsp60 in CRP assays should also become tested. C-reactive protein (CRP) is an acute-phase reactant in humans, rabbits, and a number of additional mammalian varieties. It is indicated and secreted primarily by hepatocytes, but recently, local production at sites of swelling by monocytes has also been reported ...
Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.
We recruited a random sample of men aged 50-69 years from the registers of general practices in the Merton, Sutton, and Wandsworth District Health Authority area, south London. A total of 612 men were invited and 413 (67%) attended. Of these, 25 were non-white and were excluded. Information was obtained on history and symptoms of coronary heart disease, lifestyle, and socioeconomic circumstances, as described previously. Cardiovascular risk factor profiles and serological tests for H pylori and C pneumoniae were also performed as described.11 Electrocardiograms were Minnesota coded. We took tracings to indicate coronary heart disease if they showed any of the following: Q waves, ST segment depression, left bundle branch block, or T wave inversion. Only the 303 men who had complete cardiovascular risk factor profiles were included in the study.. C Reactive protein concentration was measured by in house enzyme linked immunosorbent assay (ELISA). Rabbit antihuman C reactive protein (Dako) was used ...
Results The prevalence of RCT was higher in patients with HOA group (192/307, 62.5%) than those without HOA (410/827, 49.5%, p,0.010). Among 307 with HOA, patients with RCT were older (62.69±7.04 vs. 59.11 ±7.69, p,0.001) and showed higher hs-CRP (1.51±3.78 vs. 0.67±0.70, p=0.004) and lower HDL levels (55.66±15.46 vs. 60.48±12.45, p=0.003) compared to those without RCT. There were no significant differences in gender, smoking, comorbidities, work period, body mass index, number of affected joints, HOA severity, and prevalence of erosive HOA between both groups. Multiple logistic regression analysis showed significant associations of age (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.02 - 1.10), serum levels of hsCRP (OR 1.37, CI 1.04 - 1.80), and HDL (OR 2.13, CI 1.14 - 3.98) with RCT in HOA patients. ...
C-reactive proteins are proteins that identify viral and bacterial infections that can cause inflammation. They are also used in identifying colon cancer and pulmonary disease. Normal C-reactive proteins have a protein structure that resembles a jellyroll. C-reactive proteins are part of the pentraxin family and were first identified by Tillet and Frances.
A study of the association of Herpes simplex virus 1 and 2 exposure to early atherosclerosis using high C-reactive protein level as a marker was carried out in US born, non-pregnant, 20-49 year olds participating in a national survey between 1999 and 2004. Participants were required to have valid results for Herpes simplex virus 1 and 2 and C-Reactive Protein for inclusion. Cases were those found to have a high C-reactive protein level of 0.3-1 mg/dL, while controls had low to normal values (0.01-0.29 mg/dL). Overall, there were 1211 cases and 2870 controls. Mexican American and non-Hispanic black women were much more likely to fall into the high cardiac risk group than the other sex race groups with proportions of 44% and 39%, respectively. ^ Herpesvirus exposure was categorized such that Herpes simplex virus 1 and 2 exposure could be studied simultaneously within the same individual and models. The HSV 1+, HSV 2- category included the highest percentage (45.63%) of participants, followed by HSV 1-,
Provides device manufacturers and FDA staff with updated recommendations concerning 510(k) submissions for various types of assays for C Reactive Protein (CRP).
Description of disease C-Reactive Protein Test (CRP). Treatment C-Reactive Protein Test (CRP). Symptoms and causes C-Reactive Protein Test (CRP) Prophylaxis C-Reactive Protein Test (CRP)
Use of statin and/or aspirin therapy had negligible effects on the comparisons with the HNF1A-MODY group (Table 1). In the type 2 diabetic group, the hs-CRP level was the same for the statin/aspirin users as for the nonusers (P = 0.27), whereas in the type 1 diabetic group those taking statins and/or aspirin had a higher hs-CRP than nonusers (P = 0.004). Thus, it seems unlikely that use of these drugs would lower hs-CRP toward the range seen in the HNF1A-MODY group. In contrast, adjustment for BMI had a large impact on the estimated means (Table 1) and, given the correlation between BMI and CRP (r2 = 0.28, P , 10−6 for control subjects), abolished much of the difference observed between the type 2 diabetic and other groups. However, the differ- ences in hs-CRP levels between the HNF1A-MODY and other groups were preserved (P ≤ 0.01). Estimated mean adjusted hs-CRP (95% CI) levels for the HNF1A-MODY group compared with the other diabetic groups combined were 0.28 (0.16-0.49) vs. 0.82 ...
Porcine C-Reactive Protein/CRP ELISA Kit (Colorimetric). High sensitivity ELISA kit for detection of C-Reactive Protein/CRP. Backed by our 100% Guarantee.
PubMed journal article Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrom were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Prognostic role of serum C-reactive protein in esophageal cancer: a systematic review and meta-analysis Ying Huang,1 Ji-Feng Feng,2 Jin-Shi Liu,2 Qi-Xun Chen21Department of Operating Theatre, 2Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaBackground: Recent studies have shown that C-reactive protein (CRP) is a useful predictive factor in several cancers; however, its role in esophageal cancer (EC) is controversial.Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I2
Background: C-reactive protein (CRP) is often used as a clinical marker of acute systemic inflammation. Since low grade inflammation is evident in chronic diseases such as chronic obstructive pulmonary disease (COPD), new methods have been developed to enhance the sensitivity of CRP assays in the lower range. A study was undertaken to investigate the discriminative value of high sensitivity CRP in COPD with respect to markers of local and systemic impairment, disability, and handicap. Methods: Plasma CRP levels, interleukin 6 (IL-6) levels, body composition, resting energy expenditure (REE), exercise capacity, health status, and lung function were determined in 102 patients with clinically stable COPD (GOLD stage II-IV). The cut off point for normal versus raised CRP levels was 4.21 mg/l. Results: CRP levels were raised in 48 of 102 patients. In these patients, IL-6 ( ...
C-Reactive Protein antibody LS-C14638 is an unconjugated mouse monoclonal antibody to human C-Reactive Protein (CRP). Validated for ELISA and WB.
A 5 year old boy is brought to the accident and emergency department with pain in his left leg. The previous day he limped markedly and now he refuses to walk. History is negative for injury and positive for fever in a previously well, immunised child who is developmentally normal. Concerned about septic arthritis, the junior doctor requests a blood count, erythrocyte sedimentation rate, and C reactive protein concentration, and requests review by the paediatric team. ...
However, a low CRP level does not always mean that there is no inflammation present. Levels of CRP may not be increased in people with rheumatoid arthritis and lupus. The reason for this is unknown.. A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a persons risk for heart disease. Many consider a high CRP level to be a risk factor for heart disease. However, it is not known whether CRP is merely a sign of cardiovascular disease or if it actually plays a role in causing heart problems.. ...
Serum C-reactive protein (CRP) concentration was measured by a new solid phase ligand-binding radiometric monoclonal antibody immunoassay in a prospective study of 193 consecutively born preterm infants. In 104 with no clinical or laboratory evidence of infection the median CRP in cord serum was 0.125 mg/l (range 0.011-6.0 mg/l), at 24 h it was 1 mg/l (0.016-7.0) and at 48 h 2 mg/l (0.400-8.0). The present highly sensitive assay has enabled these normal ranges to be defined for the first time, at levels below the threshold of non-labelled immunoassays and of all commercially available CRP assays. The values in cord serum were significantly lower than in normal healthy adults (median 0.8 mg/l, range 0.07-29 mg/l, n = 468). Arterial catheterisation and endotracheal intubation, in the absence of infection, did not appear to elevate CRP, nor did cerebral germinal layer or intraventricular haemorrhage. Among nine infants with confirmed septicaemia eight had a serum CRP level raised at least once ...
The present study was undertaken to assess plasma C-reactive protein levels in pregnant women with and without periodontal disease. The study was designed as a prospective cohort study involving a sample size of 45 pregnant subjects in the age of 20-40 were selected from RavindraNath Tagore Medical College and hospital with gestational age of 2-12 weeks divided into 3 groups : Control group (15 healthy non pregnant female without periodontitis; group A; study group - 15 pregnant females with periodontitis - group B) study group (15 pregnant patients without periodontitis) Group C. Periodontal disease activity was recorded at baseline for all groups using month mirror and UNC-15 periodontal probe and Russells Index was recorded. Samples were taken for estimation of C-reactive protein levels from all groups at 2-12 weeks of gestation. CRP levels were determined using latex-agglutination-test. The results revealed a statistically significant increase in the levels of CRP in pregnant women with ...
Purpose: We aimed to establish an inflammatory prognostic index (IPI) in early and advanced non-small cell lung cancer (NSCLC) patients based on hematologic and biochemical parameters and to analyze its predictive value for NSCLC survival. Materials and Methods: A retrospective review of 685 patients with early and advanced NSCLC diagnosed between 2009 and 2014 was conducted with collection of clinical, and laboratory data. The IPI was calculated as C-reactive protein × NLR (neutrophil/ lymphocyte ratio)/serum albumin. Univariate and multivariate analyses were performed to assess the prognostic value of relevant factors. Results: The optimal cut-off value of IPI for overall survival (OS) stratification was determined to be 15. Totals of 334 (48.8%) and 351 (51.2%) patients were assigned to high and low IPI groups, respectively. Compared with low IPI, high IPI was associated with older age, greater tumor size, high lymph node involvement, distant metastases, advanced stage and poor performance status.
The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that finds lower levels of C-reactive protein (CRP). This protein measures general levels of inflammation in your body. The hs-CRP can be used to find the risk for heart disease and stroke in people who dont already have heart disease. It can also be used to help predict how well a person who has heart disease might recover or to predict how the person might respond to treatment. The hs-CRP test is different than the standard CRP test. The standard test measures high levels of the protein to find different diseases that cause inflammation. The hs-CRP test measures low levels and focuses on the risk of heart disease and stroke. ...
Most tissue-damaging processes such as infections, inflammatory diseases and malignant neoplasms are associated with a major acute phase response of the C-reactive protein (CRP) and other acute reactants e.g. AAT, AAGP, C3C, C4 HAPT. The CRP response frequently precedes clinical symptoms, including fever. In normal healthy individuals CRP is a trace protein with a range up to 5 mg/L. After onset of an acute phase response the serum CRP concentration rises rapidly and extensively. Levels of up to thousand times the normal value are associated with severe stimuli such as myocardial infarction, major trauma, surgery or malignant neoplasm. CRP has a half-life of only a few hours, making it an ideal tool for clinical monitoring ...
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More subtle, early indicators of problems could include headaches, muscles aches, fatigue, muscle stiffness, nausea, vomiting, diarrhea or constipation, gas, abdominal discomfort and even emotional problems including depression. These could be related to food sensitivities and intolerances. The most common food intolerances include dairy (lactose), wheat (gluten), yeast, soy, corn, eggs and even some artificial sweeteners.. How can you know if you have chronic inflammation if you dont have symptoms or a diagnosis?. You can find out if you have inflammation by having your C- reactive protein levels tested. The high sensitivity C-reactive protein, is the preferred indicator of chronic, low-grade inflammation.. What should I do if I have high levels of C-reactive protein?. If your C-reactive protein levels are high, you will first want to talk to your doctor to find out if there is an underlying infection, allergy, autoimmune disorder or other contributing disease. If not, your excess weight could ...
TY - JOUR. T1 - Gender and C-reactive protein. T2 - Data from the Multiethnic Study of Atherosclerosis (MESA) cohort. AU - Lakoski, Susan G.. AU - Cushman, Mary. AU - Criqui, Michael. AU - Rundek, Tatjana. AU - Blumenthal, Roger S.. AU - DAgostino, Ralph B.. AU - Herrington, David M.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Background: American Heart Association/Centers for Disease Control and Prevention guidelines support the measurement of C-reactive protein (CRP) to further risk stratify individuals at intermediate risk (10%-20% 10-year risk) for heart disease. Determining gender-specific differences in CRP may alter how CRP levels are interpreted and used to determine risk. Methods: MESA is a prospective cohort consisting of 6814 men and women aged 45 to 84 years recruited from 6 US communities. Nonparametric analyses were performed to determine differences in CRP levels by gender in the entire cohort and after stratifying by use of estrogen medication (n = 944). Stratifying by median body mass ...
Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes. Kahn, Steven E.; Zinman, Bernard; Haffner, Steven M.; ONeill, M. Colleen; Kravitz, Barbara G.; Yu, Dahong; Freed, Martin I.; Herman, William H.; Holman, Rury R.; Jones, Nigel P.; Lachin, John M.; Viberti, Giancarlo C. // Diabetes;Aug2006, Vol. 55 Issue 8, p2357 The inflammatory factor C-reactive protein (CRP) and the fibrinolytic variables fibrinogen and plasminogen activator-1 (PAI-1) are associated with long-term cardiovascular morbidity. To determine the contribution of body adiposity (BMI), insulin sensitivity (homeostasis model assessment of... ...
BACKGROUND: Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances. METHODS: We meta-analysed individual records of 160 309 people without a history of vascular disease (ie, 1.31 million person-years at risk, 27 769 fatal or non-fatal disease outcomes) from 54 long-term prospective studies. Within-study regression analyses were adjusted for within-person variation in risk factor levels. RESULTS: Log(e) CRP concentration was linearly associated with several conventional risk factors and inflammatory markers, and nearly log-linearly with the risk of ischaemic vascular disease and non-vascular mortality. Risk ratios (RRs) for coronary heart disease per 1-SD higher log(e) CRP concentration (three-fold higher) were 1.63 (95% CI 1.51-1.76) when initially adjusted for age
C-reactive protein is a serum acute-phase reactant that increases several thousand-fold in concentration during inflammation in most mammals. However, mouse C-reactive protein is considered to be a minor acute-phase reactant, since its blood level increases only from approx. 0.1 to 1-2 micrograms/ml. A mouse genomic clone of approximately 5 kb was obtained to determine the molecular basis for the regulation of the expression of mouse C-reactive protein. Several cis-acting elements in the 5′ flanking region that potentially regulate transcription were identified: two glucocorticoid-responsive elements, two CCAAT-enhancer-binding protein C (C/EBP) consensus elements that are required for the interleukin-1 responsiveness of some acute-phase reactant genes, an interleukin-6-responsive element, two hepatocyte nuclear factor-1 (HNF-1) elements and a single heat-shock element. Transfection of the hepatoma cell line Hep 3B.2 with a pCAT expression vector containing the 5′ flanking sequence from ...
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein.
Background: Studies regarding the effects of high protein (HP) diet on cardiovascular (CVD) risk factors have reported contradictory results.. Objective: In present study, we aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.. Design: In this randomized controlled trial, we recruited 60 overweight and obese women, aged 20-65 years into HP or control energy restricted diets for three months (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). Total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. Fasting blood samples, hs-CRP, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines. ...
Results At one-month follow-up, 22 patients (33%) had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.14 to 2.98; p = 0.013) even after adjusting for age (OR 2.22; 95% CI 1.25 to 3.93; p = 0.006), for gender (OR 1.89; 95% CI 1.16 to 3.09; p = 0.011), or duration of arrhythmia (OR 1.86; 95% CI 1.13 to 3.07; p = 0.015). On multivariate analysis, CRP was the only independent predictor of arrhythmia recurrence (OR 2.19; 95% CI 1.05 to 4.55; p = 0.036). ...