Post-transcriptional protein synthesis by GH3 cloned pituitary cells, which secrete prolactin and growth hormone, is dependent on Ca2+. The effects of antagonists of prolactin secretion were examined on overall protein synthesis in GH3 cells as a function of cellular Ca2+ depletion and restoration at varying concentrations of extracellular Ca2+. Leucine incorporation by Ca2+-depleted cells during short incubations was reduced by 80-90%. Trifluoperazine at micromolar concentrations inhibited leucine incorporation in a Ca2+-dependent manner. The extent of inhibition varied with extracellular Ca2+ concentration and was fully reversed at higher Ca2+ concentrations. Similar patterns of inhibition of leucine incorporation were observed with nifedipine, verapamil, calmidazolium, chlorpromazine, bromocriptine, ergotamine, and the (+)- and (-)-isomers of butaclamol, but dopamine, apomorphine, and chlorpromazine sulfoxide were not inhibitory. Muscarinic agonists decreased incorporation in a Ca2+-dependent ...

3H]Spiperone, a neuroleptic/dopamine receptor ligand, binds with high affinity (Kd 0.15 nM) to a single specific site on rat corpus striatum membranes. The specific binding represents about 80% of the total binding and is displaced by dopamime, apomorphine, and stereospecifically by neuroleptics such as butaclamol and flupenthixol. However, in contrast to the striatum, only 30-40% of the binding of [3H]spiperone to limbic forebrain membranes is displaced stereospecifically by butaclamol or flupenthixol, whereas dopamine and certain spiperone analogues compete with high affinity for about 70% of the labeled sites. These additional sites are saturable, reversible, and of high affinity. Kinetic analysis of association and dissociation rates yields a Kd value (1.5 nM) in agreement with equilibrium saturation data for these sites. They also possess a precise distribution, with high amounts being found in the hippocampus, septum, and nucleus accumbens, but they are completely absent in areas such as ...

TY - JOUR. T1 - Combination of internal and external plasticization of hydroxypropylated birch xylan tailors the properties of sustainable barrier films. AU - Mikkonen, Kirsi S.. AU - Laine, Christiane. AU - Kontro, Inkeri. AU - Talja, Riku A.. AU - Serimaa, Ritva. AU - Tenkanen, Maija. N1 - Project code: 76880 PY - 2015. Y1 - 2015. N2 - To develop functional and sustainable products from future wood biorefineries, birch kraft pulp xylan was alkali-extracted and modified in aqueous solvent with hydroxypropylation to enhance its processability to films. For the first time, the roles of internal vs. external plasticization in the mechanical, thermal, and barrier performance of xylan films were systematically evaluated as a function of the degree of substitution (DS) of hydroxypropyl (HP) groups (internal plasticizer) and the added sorbitol (external plasticizer). In addition, the moisture uptake and the degree of crystallinity of hydroxypropyl xylan (HPX) films were characterized. Internal ...

Product introduction Coloress transparent oily liruid, boiling point: 170℃(133.3Pa), flash point (open):185℃.Soluble in most organic solvents.small volatility, good compatibility with resin, good plasticization effect. Resistance to coldness,...

The goal of this project is to elucidate the effect of pendant rings and crosslinking on membrane gas separation properties, and design advanced materials with superior gas permeability and selectivity, and great stability against aging and plasticization for practical separations. ...

Hi all, I am hopeing someone out there will be able to help with this question. If you make starch film with glycerol as a softner when does plasticization and antiplasticization happen and what are the differences between them? Thanks in advance. -- Yours Tim ************************************************************************** ____________ \ ______// Tim Eades - tim.eades at F-Secure.com \ \\____ F-Secure Quality Engineering Team \ __// F-Secure Corporation, PL 24, FIN-02231 Espoo, Finland \ \\ tel: +358 9 859 900, direct: +358 9 8599 0105 \ // fax: +358 9 8599 0599 gsm: +358 40 7435049 \/ web: http://www.F-Secure.com/ ...

In 2021, in the context of the bull market of commodities, the plastics market will not disappoint, and the rose sprint has been up for nearly ten years. The international crude oil surge has driven the plasticization sector to rise collectively, and pla ...

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A notable feature of the PRC of C57BL/6J Per1−/− mice is its high amplitude, which is reminiscent of the light responsiveness of Clock mutant (Δ19) heterozygous mice that have large phase shifts and low-amplitude circadian oscillations in the SCN (Vitaterna et al., 2006). This is consistent with our finding that the Per1−/− SCN is arrhythmic or has a low amplitude, irregular rhythm in vitro (Pendergast et al., 2009). The PRC of Per2−/− mice has an elongated advance zone and large phase advances. In addition, Per2−/− mice have a phase-advanced PRC, suggesting that the phase relationship between the circadian pacemaker and the onset of the activity rhythm in Per2−/− mice is altered. The PRC of Per3−/− mice is similar to the PRC of wild-type mice. This is not surprising because Per3 expression is not induced in response to light (Takumi et al., 1998; Zylka et al., 1998).. PRCs have been used to make predictions according to the discrete model of entrainment, which posits ...