Others. The Bronchodilator report does the thorough study of the key industry players to understand their business strategies, annual revenue, company profile and their contribution to the global Bronchodilator market share. Diverse factors of the Bronchodilator industry like the supply chain scenario, industry standards, import/export details are also mentioned in Global Bronchodilator Market 2017 report.. Key Highlights of the Bronchodilator Market:. A Clear understanding of the Bronchodilator market based on growth, constraints, opportunities, feasibility study.. Concise Bronchodilator Market study based on major geographical regions.. Analysis of evolving market segments as well as a complete study of existing Bronchodilator market segments.. Discover More About Report Here: http://qyresearch.us/report/global-bronchodilator-market-2017/54749/. Furthermore, distinct aspects of Bronchodilator market like the technological development, economic factors, opportunities and threats to the growth ...
COPD is now defined using the combination of a clinical history and objective evidence of airflow limitation. Data from this study show that these criteria identify patients with an accelerated rate of decline in FEV1. However, the distinction from chronic asthma with limited reversibility remains difficult, and most treatment guidelines use the spirometric response to a bronchodilator drug to aid the diagnosis and, in some cases, to make recommendations about treatment decisions.12 Previous studies have examined the ability of bronchodilator testing to differentiate between asthma and COPD in milder disease and have found no clear distinction spirometrically between the two.9,20 This has not prevented these criteria being widely recommended in the assessment of more severe COPD or in the selection of patients for inclusion in treatment trials.17,21 In this study we examined the reliability of the bronchodilator response in moderate to severe COPD defined as "poorly reversible" disease by one ...
We thank M.R. Miller for his comments on our paper regarding bronchodilator reversibility in asthma and COPD [1]. We agree that it is important to look at different ways of defining bronchodilator reversibility. In our analysis, we investigated both flow-related bronchodilator reversibility, defined by the change in forced expiratory volume in 1 s (FEV1), and volume-related bronchodilator reversibility, defined by the change in forced vital capacity. We also looked at both the change in lung function parameters expressed as percent of the baseline value and the change in FEV1 standardised by the subjects predicted value. The latter was evaluated to control for the sex, age and height dependency of lung function. The results when reversibility was expressed as percent of the predicted value (in supplementary tables E3 and E4) [1] were the same as when reversibility was expressed as percent of the baseline value. Our interpretation was therefore that, in the present study, neither flow-related ...
• Active reduction of risk factors and bronchodilator treatment are central to the management of COPD.• Regular use of long-acting bronchodilators (β‎2-agonists and antimuscarinics) is more effective than short-acting bronchodilators in patients with persistent symptoms.• Inhaled corticosteroids (ICS) combined with bronchodilators are indicated in patients with forced expiratory volume in 1s FEV1 < 50% predicted and repeated exacerbations.• Influenza vaccination is indicated for all COPD patients; while pneumococcal vaccine is recommended for COPD patients older than 65 years, and in those younger with FEV1 < 40% predicted.• Antibiotics should only be used for infectious exacerbations of COPD, while N-acetylcysteine only affects the frequency of exacerbations in patients off inhaled corticosteroids.• Mucolytic agents, antitussives, and vasodilators are not recommended in stable COPD.• All COPD patients benefit from exercise training programmes, while long-term oxygen therapy increases
Neogens Bronchodilator Group ELISA (Enzyme-Linked ImmunoSorbent Assay) test kit is a qualitative one-step kit designed for use as a screening device for the detection of Bronchodilator Group drugs and/or their metabolites. The kit was designed for screening purposes and is intended for forensic use only.. ...
Background. Important role in the management of COPD have both pulmonary specialists (PSs) and general practitioners (GPs).. Aims. To study the medical care provided for COPD patients by PSs and GPs.. Methods. Both GPs and PSs filled in specially designed questionnaires. Theyprovidedinformation for randomly selected COPD patients on smoking status, disease severity, comorbidities, therapy, exacerbations, hospitalizations and management.. Results. Information about 556 patients was collected - 60.4% (336) were males. Smokers were 68.8% of all COPD patients. On combined inhalation therapy (inhaled corticosteroid and long acting beta-2- agonist - ICS/LABA) were 37.8%; 23.7% received long-acting bronchodilator therapy and 27.2% were on therapy with short-acting bronchodilators. Concomitant cardiovascular diseases had 77.3%. From all patients 25.8% had no exacerbation for the last 12 months, 38.0% had one and 36.2% had 2 or more, 33.5% had hospitalization due to COPD exacerbation (HE) and 21.9% due ...
Here authors performed a comparative analysis of the efficacy of umeclidinium and vilanterol bronchodilator fixed-dose, when compared to other available dual-bronchodilator combinations, in treating patients with COPD.
This test is often done in your healthcare providers office. The reversibility testing steps usually include the following: 1. You will be asked to take a deep breath and then blow into the mouthpiece of the spirometer as hard as you can. This is a baseline measurement. The spirometer records the results. 2. You will be given a dose of bronchodilator medicine using an inhaler or nebulizer.. 3. You will wait for about 15 minutes.. 4. You will take a deep breath and then blow into the mouthpiece spirometer as hard as you can. Again, the spirometer records the results. 5. You will be asked to blow into the mouthpiece more than once to get the best reading possible. ...
Long-acting bronchodilators (LABD) are similar in structure to short-acting selective beta2-adrenoceptor agonists, but have much longer side chains resulting in a 12-hour effect, and are used to give a smoothed symptomatic relief (used morning and night). While patients report improved symptom control, these drugs do not replace the need for routine preventers, and their slow onset means the short-acting dilators may still be required. In November 2005, the American FDA released a health advisory alerting the public to findings that show the use of long-acting β2-agonists could lead to a worsening of symptoms, and in some cases death. Currently available long-acting beta2-adrenoceptor agonists include salmeterol, formoterol, bambuterol, and sustained-release oral albuterol. Combinations of inhaled steroids and long-acting bronchodilators are becoming more widespread; the most common combination currently in use is fluticasone/salmeterol (Advair in the United States, and Seretide in the United ...
According to a Canadian study published May 20 in JAMA Internal Medicine, older patients with chronic obstructive pulmonary disease (COPD) who are new users of long-acting beta agonists (LABAs) and long-acting anticholinergics (LAAs) are at an increased risk of cardiovascular events. Although LABAs salmeterol xinafoate and formoterol fumarate and the LAA tiotropium bromide monohydrate generally are considered effective treatments for COPD, the cardiovascular safety of the medications remains a matter of debate.
Indacaterol is a long-acting bronchodilator. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
Results The distribution of change was right skewed with 416 subjects having a fall in FEV1 post BD. The table shows the median baseline FEV1 and the male to female ratio for those meeting (+ve) and not meeting (-ve) the various BDR criteria. Definitions based on % change from baseline were biased to positive results in those with smaller pre BD FEV1. BDR criteria including absolute change were biased to those with a larger FEV1 and gave a higher proportion of males with a positive BDR result. The criterion ,400ml FEV1 change gave the highest male to female ratio of 2.34. Criteria including both absolute and change as % predicted had both sex and FEV1 size bias whereas using only change as % predicted avoided these biases.. ...
This network meta-analysis compares four different classes of long-acting inhalers for people with COPD who need more than short-acting bronchodilators. Quality of life and lung function were improved most on combination inhalers (LABA and ICS) and least on ICS alone at 6 and at 12 months. Overall L …
Despite being an irreversible airflow obstruction disorder, bronchodilators are still used in the treatment of COPD. Different patients of bronchitis need
A total of 179 Tyneside children who had suffered at least one episode of wheeze since school entry were seen at the age of 7. All but 14 had visited a doctor for chest symptoms, but a diagnosis of asthma had been offered to the parents of only 21 children, including three of the 56 children experiencing four to 12 wheezy episodes a year and 11 of the 31 children experiencing more than 12 episodes a year. Bronchodilator treatment was rarely offered in the absence of such a diagnosis, and two thirds of the children had never received a bronchodilator. Of the children experiencing four or more episodes a year, only a third had received bronchodilator drugs regularly, though half had lost more than 50 days from school because of wheeze. School absenteeism fell 10-fold in the 31 children finally offered continuous prophylactic treatment. Although many doctors had feared that use of the word "asthma" would cause anxiety, parents were uniformly relieved when given an explanation of their childs ...
Worldwide patterns of bronchodilator responsiveness: results from the Burden of Obstructive Lung Disease study. Wan C Tan; William M Vollmer; Bernd Lamprecht; David M Mannino; Anamika Jithoo; Ewa Nizankowska-Mogilnicka; Filip Mejza; Thorarinn Gislason; Peter G J Burney; A Sonia Buist // Thorax;Aug2012, Vol. 67 Issue 8, p718 RationaleCriteria for a clinically significant bronchodilator response (BDR) are mainly based on studies in patients with obstructive lung diseases. Little is known about the BDR in healthy general populations, and even less about the worldwide patterns.Methods10 360 adults aged... ...
The difficulty arises in deciding on the pharmacological treatment for each group. Generally, group A patients receive short-acting bronchodilators, whereas group B must be given LAMA or a LABA, and groups C and D should take an ICS in combination.. Conclusion. The disease progression of COPD should be explained to patients to help them overcome the denial of the causality of smoking. It is very important for patients to stay active; patients with symptomatic airflow obstruction should be offered a rehabilitation program as part of an optimal treatment plan.. It is difficult to treat dyspnoea or completely eliminate it, and this can require the use of double combinations of bronchodilators, i.e. LAMA plus LABA. If the patient does not respond, then a triple combination is recommended, with the addition of ICS. Some patients still do not improve, and one should consider adding a low dose of theophylline.20,21 Sometimes, nebulized bronchodilators may help as a back-up management. The last resort ...
Probric bambuterol HCL Long Acting Bronchodilator Composition: Each 10 ml contains: Bambuterol HCI . 10 mg Properties: Bambuterol is a prod rug of ter
Neither the number of siblings nor whether children were looked after in a nursery during the day seemed to influence frequency of bronchodilator use.. Perhaps most surprisingly, in view of the information given to the parents, we found occasional evidence of canister dumping. This behaviour has also been recorded in studies using inhaler timers in adults and older children.5 7 In canister dumping, patients actuate the inhaler repetitively but are thought not to inhale the drug. In adults the reasons for this behaviour are not known and seem to be unrelated to asthma symptoms.. In studies of adherence to an inhaled prophylactic regimen adult patients and older children have tended to overestimate their use of regular inhaled drug treatment.5 6 7 In contrast, the parents underestimated bronchodilator use in our study. One possible explanation is that a target exists for prophylactic treatment (the prescribed dose). patients may overreport to approach this, whereas there is no such target for ...
Four Presentations to Feature Clinical Results and Drug Delivery Characteristics of Pearl s Combination Bronchodilator, Pearl Therapeutics Inc., a company devel
The bpacnz COPD prescribing tool uses the severity of the patients symptoms and their exacerbation history to categorise patients from A - D. Patients in category A, i.e. less symptoms and low exacerbation risk, should be prescribed a bronchodilator.2 Treatment options for patients in category A include "as needed" use of either a SAMA, SABA or a fixed-dose combination SAMA/SABA, or daily use of a LAMA or LABA. A SABA/SAMA combination inhaler is more effective at improving symptom control and lung function than either medicine in isolation.2 If patients do not obtain sufficient benefit from one bronchodilator, a switch to an alternative class of bronchodilator may be appropriate.2. ...
Olodaterol is a long-acting bronchodilator. Tiotropium is an anticholinergic. These medications work by relaxing muscles in the airways to improve breathing.
... Bronchodilators is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help
Your doctor may send you to an allergist (disclose: AL-ur-jist), a inimitable doctor who helps people who bear allergies. Some women with medium to obdurate symptoms puissance dearth a long-acting bronchodilator such as Serevent. So when the sniffling symptoms whip, how at ones desire you comprehend if its a chilling, allergies, or a sinus problem?. Whether it be gluten, dairy or an collection of other foods, identifying and eliminating these triggers from your nutriment could serve you head junction cut to the quick 9 medications that can cause heartburn order genuine nitroglycerin on-line symptoms nausea headache. Advantages: the measure of fluid required intraoperatively elude potential toxic effects of inhalational wish be: anaesthetics and utilization of nitrous oxide; livelihood fluid: 03:00 10:30, 1. In counting up, all fluids (notably blood) muscular blocking drugs and is being ventilated, should be warmed to 37 Cusingafluid the ...
Your doctor may send you to an allergist (disclose: AL-ur-jist), a inimitable doctor who helps people who bear allergies. Some women with medium to obdurate symptoms puissance dearth a long-acting bronchodilator such as Serevent. So when the sniffling symptoms whip, how at ones desire you comprehend if its a chilling, allergies, or a sinus problem?. Whether it be gluten, dairy or an collection of other foods, identifying and eliminating these triggers from your nutriment could serve you head junction cut to the quick 9 medications that can cause heartburn order genuine nitroglycerin on-line symptoms nausea headache. Advantages: the measure of fluid required intraoperatively elude potential toxic effects of inhalational wish be: anaesthetics and utilization of nitrous oxide; livelihood fluid: 03:00 10:30, 1. In counting up, all fluids (notably blood) muscular blocking drugs and is being ventilated, should be warmed to 37 Cusingafluid the ...
Verona Pharma has started a Phase 2 clinical trial to evaluate the potential of RPL554 in combination with a dual bronchodilator therapy in COPD patients.
In cases of worsening of respiratory symptoms in patients with allergic asthma (shortness of breath, wheezing, rattling, choking) inhaled bronchodilators are used (they do not belong to the group of medicines which control allergic diseases) with possible brief application of high doses of corticosteroids.. The aim of the use of drugs in the treatment of allergic diseases is prevention and reduction of the symptoms to the extent that they do not interfere with the patient`s everyday life. Ideal result of therapy would be the lack of any symptoms. The therapy begins with a single or combination of drugs at lower doses. If necessary, the doses of already used drugs increase or new medications are added, until a satisfactory control of the disease is achieved. For seasonal allergens the therapy should always start a few weeks (at least 2 weeks) before the start of the season of flowering of plants which pollen causes sensibilization and continuously carry it out during the season.. For year-round ...
When added to standard bronchodilator therapies in the two six-month studies, a clear trend for the reduction of exacerbations was observed with roflumilast, over and above what was achieved with these therapies alone. Advair Diskus Help To Pay Buy Cheap Torsemide - ...
Symptomatic treatment of patients with severe COPD (FEV1 < 50% predicted normal) and a history of repeated exacerbations, who have significant symptoms despite regular therapy with long-acting bronchodilators. Strength ...
If you use a short-acting bronchodilator as a quick relief for acute attacks three times or more a week, this means that your asthma is not under control. Please see your doctor as soon as you can. ...
This is a six-week, multi-centre, randomised, double-blind, triple-dummy, parallel group pilot study to compare the bronchodilator efficacy and safety of the long-acting bronchodilator tiotropium (Spiriva, 18 µg q.d.) to the free combination of fluticasone (Flixotide, 250 µg b.i.d.) and salmeterol (Serevent, 50 µg b.i.d.) in patients with COPD.. Following an initial screening at Visit 1, subjects will enter a two-week run-in period during which they will record daily rescue salbutamol use in the Patient Daily Diary Card. At Visit 1, pre-dose and post-bronchodilator pulmonary function tests (PFT) will be measured. Four inhalations of ipratropium (20 µg per puff) and four inhalations of salbutamol (100 µg per puff) will be administered 60 minutes prior to obtaining post-bronchodilator PFT measurement.. At Visit 2, a pre-dose PFT will be performed prior to first administration of trial medication. Treatment with blinded study medication (tiotropium or fluticasone + salmeterol) will start in ...
Few data are available on the bronchodilator response in preschool children. This study was set up to study baseline lung function and bronchodilator responses in healthy and asthmatic children younger than 7 yrs old. In 281 preschool children attending kindergarten (age range 2.7-6.6 yrs old) respiratory system resistance (Rrs) and reactance (Xrs) by impulse oscillation system at 5, 10, 15, 20, 25 and 35 Hz as well as resonance frequency (f0) were measured before and 20 min after 200 microg inhaled salbutamol by a metered-dose inhaler connected to a spacer device. Thirty-four of them were diagnosed as asthmatics based on a validated standardized questionnaire. The mean Rrs (+/-SD) at 5 Hz (Rrs,5) was 1.03 (+/-0.24) kPa x L(-1) x s for healthy children and 1.09 (+/-0.26) kPa x L(-1) x s for stable asthmatics. The mean change in Rrs,5 after salbutamol was -0.13 (+/-0.20) kPa x L(-1) x s for the healthy children and -0.09 (+/-0.25) kPa x L(-1) x s for the asthmatic group. The scatter for the ...
OBJECTIVES: To assess the Pre-bronchodilator criteria and the Post-bronchodilator criteria of FEV1/FVC ratio in diagnosing Airflow obstruction. METHODS: An observational study was conducted from 1988 to 2006 at the Aga Khan University Hospital Patients referred to the pulmonary function test laboratory for spirometry with bronchodilator reversibility at the hospital during the above said period were enrolled. Forced spirometry was performed according to ATS guidelines. All patients who had pre-bronchodilator criteria of airflow obstruction were analyzed and compared with the post bronchodilator criteria. RESULTS: A total of 4222 individuals underwent spirometry out of which 4072 individuals were studied. Using the pre bronchodilator criteria, 1375 (34%) patients had airflow obstruction. Applying the post bronchodilator criteria on the same patients, 1098 (27%) had evidence of airway obstruction. Out of these 1375 patients who had airflow obstruction by using pre-bronchodilator criteria, 277 (20%)
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Single Dose, Double-blind, Double-dummy, 3 Period Cross-over, Placebo Controlled Clinical Trial to Assess the Reate of Onset of Action of Inhaled Aclidinium Bromide 200µg Compared to Placebo and Tiotropium 18µg in Patients With Chronic Obstructive Pulmonary Disease (COPD ...
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article{4206324, author = {Braido, Fulvio and Baiardini, Ilaria and Cazzola, Mario and Brusselle, Guy and Marugo, Fiorenza and Canonica, Giorgio Walter}, issn = {0954-6111}, journal = {RESPIRATORY MEDICINE}, keywords = {Health status,OBSTRUCTIVE PULMONARY-DISEASE,Quality of life,Long-acting bronchodilators,COPD,TWICE-DAILY SALMETEROL,FORMOTEROL DRY POWDER,ONCE-DAILY TIOTROPIUM,LUNG-FUNCTION,CONTROLLED-TRIAL,DOUBLE-BLIND,NEBULIZED FORMOTEROL,IPRATROPIUM BROMIDE,COMBINATION THERAPY}, language = {eng}, number = {10}, pages = {1465--1480}, title = {Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD}, url = {http://dx.doi.org/10.1016/j.rmed.2013.08.007}, volume = {107}, year = {2013 ...
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TY - JOUR. T1 - Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV. AU - Anthonisen, Nicholas R.. AU - Connett, John E.. AU - Kiley, James P.. AU - Altose, Murray D.. AU - Bailey, William C.. AU - Buist, A. Sonia. AU - Conway, William A.. AU - Enright, Paul L.. AU - Kanner, Richard E.. AU - OHara, Peggy. AU - Owens, Gregory R.. AU - Scanlon, Paul D. AU - Tashkin, Donald P.. AU - Wise, Robert A.. PY - 1994/11/16. Y1 - 1994/11/16. N2 - Objective. - To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive pulmonary disease. Design. - Randomized clinical trial. Participants randomized with equal probability to one of the following groups: (1) smoking intervention plus bronchodilator, (2) smoking intervention plus placebo, or (3) no intervention. Setting. - ...
1Dugernier J et al. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-Mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study. Pharmaceutical Research. 2017;34:290-300. 2Chweich H et al. Effect on Airflow of Bronchodilator Therapy Delivered via Vibrating-Mesh versus Jet Nebulizers in Acute Asthmatics in an Emergency Department. Poster at ATS. 2019.. 3Dunne RB and Shortt S. Comparison of bronchodilator administration with vibrating-mesh nebulizer and standard jet nebulizer in the emergency department. The American Journal of Emergency Medicine. 2018;36(4):641-646.. 4Aerogen Solo System Instruction Manual.. *Please refer to Aerogen Solo Instruction Manual for approved Aerogen set-ups.. PM617. Digital Ads PM619, PM620, PM621, PM622, PM623 & PM630. ...
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that is associated with airway obstruction. COPD is a major cause of chronic morbidity and mortality throughout the world. It is a progressive condition, but is partially reversible through treatment, especially when diagnosed early in its clinical course. Bronchodilators are important in treating the symptoms of COPD. Long-acting bronchodilators provide sustained symptom relief and are usually preferred in patients with COPD. Combining bronchodilators with different mechanisms of action appears to improve efficacy.
The present invention relates to particulate products which may be prepared by methods and apparatus using supercritical fluids. More particularly, the invention relates to pharmaceutical products, in particular easily handled and easily fluidized crystalline forms of salmeterol xinafoate, with controlled particle size and shape.
Learn about how SPIRIVA RESPIMAT (tiotropium bromide), a long-acting muscarinic antagonist (LAMA), works differently than a long-acting beta-agonist (LABA), to block bronchoconstriction. Please visit website for Important Safety Information.
Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The effi cacy and safety of the phosphodiesterase-4 inhibitor rofl umilast have been investigated in studies of patients with moderate-to-severe COPD, but not in those concomitantly treated with longacting inhaled bronchodilators. The eff ect of rofl umilast on lung function in patients with COPD that is moderate to severe who are already being treated with salmeterol or tiotropium was investigated. Methods In two double-blind, multicentre studies done in an outpatient setting, after a 4-week run-in, patients older than 40 years with moderate-to-severe COPD were randomly assigned to oral rofl umilast 500 μg or placebo once a day for 24 weeks, in addition to salmeterol (M2-127 study) or tiotropium (M2-128 study). The primary endpoint was change in prebronchodilator forced expiratory volume in 1 s (FEV1). Analysis was by intention to treat. The studies are registered with ClinicalTrials.gov, ...
RIDGEFIELD, Conn., Aug. 14, 2014 /PRNewswire/ -- FDA Advisory Committee Recommends Approval of Tiotropium Respimat® for the Maintenance Treatment of COPD....
The study by DAlonzo and colleagues fuels the controversy surrounding the appropriate use of selective β2-agonists. Recent concerns about increasing prevalence and morbidity from asthma have demanded a reassessment of our current therapeutic regimens. Advances in the understanding of the pathogenesis of asthma have suggested that in many patients, attention must be directed at the underlying inflammatory processes. Thus, it has been proposed that if short-acting bronchodilators are required on a regular basis, indicating that the inflammatory process has become well established, appropriate care would include the use of an additional agent, such as inhaled steroids, cromolyn, or nedocromil (1). The importance of supplemental medications is underlined in this study. 74% of patients receiving salmeterol, 75% receiving placebo, and 80% receiving albuterol were routinely also receiving inhaled steroids, theophylline, or cromolyn. Only 15 patients were forced to withdraw because of increasing ...
ABSTRACT: BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is defined by post-bronchodilator spirometry. Data on normal values come predominantly from pre-bronchodilator spirometry. The effects of this on diagnosis are unknown. METHODS: Low
FRANKLIN LAKES, N.J. -The class of drugs known as long-acting beta agonists can provide many benefits to patients with asthma and chronic obstructive pulmonary disease, but medical experts have long warned of dangers in using the drugs alone. Still, according to data from a study last month, many patients continue using LABAs as a monotherapy despite the risks. The Medco Research Institute and the Medco Pulmonary Therapeutic Resource Center, research arms of pharmacy benefit manager Medco Health Solutions, found that close to one-third of patients using LABAs use them without other controller medications. And this, according to experts, puts them at risk of worsening disease symptoms or even death. LABAs include such drugs as GlaxoSmithKlines Serevent (salmeterol xinafoate) and Foradil (formoterol fumarate) by Merck and Novartis.. The researchers found that 31% of patients prescribed either drug didnt use them together with controller medications, but those who received treatment from an ...
In a 12-week, randomised, double-blind, double-dummy, active- and placebo-controlled study, 565 adult patients with asthma were evaluated for the bronchodilator efficacy of a non-CFC (norflurane) salbutamol pressurised inhaler (193 patients) in comparison to a CFC salbutamol pressurised inhaler (186 patients). Serial FEV1 (Forced Expiratory Volume) measurements demonstrated that two inhalations of a non-CFC (norflurane) salbutamol pressurised inhaler produced significantly greater improvement in pulmonary function than placebo and produced outcomes which were clinically comparable to a CFC salbutamol pressurised inhaler. The mean time to onset of a 15% increase in FEV1 was 6 minutes and the mean time to peak effect was 50 minutes. The mean duration of effect as measured by a 15% increase in FEV1 was 3 hours. No statistically significant or clinical meaningful differences were seen in the safety parameters, including the overall adverse event rates, heart rate, blood pressure, serum potassium or ...
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