Inotropic and chronotropic effects of guanethidine and bretylium have been observed in heart-lung preparations made from normal and chronically reserpinized dogs. Guanethidine (0.3 to 30 mg.) in the untreated preparation had marked positive inotropic and chronotropic effects, whereas after pretreatment with reserpine it had a striking negative inotropic effect and no effect on heart rate. Guanethidine given to preparations made from animals pretreated with guanethidine had a negative inotropic effect smaller than that seen after reserpine pretreatment. Bretylium (0.3 to 30 mg.) in the untreated preparation had both positive inotropic and positive chronotropic effects. In the chronically reserpinized animal, the positive inotropic effect of bretylium persisted though it was reduced to about one-quarter of the original size. The positive chronotropic effect of bretylium in this circumstance was reversed to a negative chronotropic effect. These effects are interpreted as indirect but strong ...
Bretylium (also bretylium tosylate) is an antiarrhythmic agent. It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is considered a class III antiarrhythmic. The dose is 5-10 mg/kg and side effects are high blood pressure followed by low blood pressure and ventricular ectopy. Originally introduced in 1959 for the treatment of hypertension. Its use as an antiarrhythmic for ventricular fibrillation was discovered and patented by Marvin Bacaner in 1969 at the University of Minnesota. The American Heart Association removed bretylium from their 2000 ECC/ACC guidelines due to its unproven efficacy and ongoing supply problems. Many have cited these supply problems as an issue of raw materials needed in the production of Bretylium. By the release of the AHA 2005 ECC/ACC guidelines there is no mention of Bretylium and it is virtually unavailable throughout most of the world. As ...
Bretylium tosylate (Bretylol) has recently been approved for parenteral use against resistant ventricular arrhythmias. The pharmacologic action of bretylium is complex, and its antiarrhythmic action differs significantly from other drugs. Bretylium is an adrenergic neuronal blocking agent taken up selectively at peripheral adrenergic nerve terminals, where it initially releases norepinephrine (sympathomimetic effect) and then produces adrenergic neuronal blockade. It has direct cardiac membrane effect to prolong action potential duration and effective refractory period but, unlike other membrane active antiarrhythmic agents, does not depress conduction velocity or automaticity. Bretylium increases ventricular fibrillation threshold and prevents the decrease in ventricular fibrillation threshold associated with myocardial ischemia. It does not depress myocardial contractility. Clinical studies have shown parenteral bretylium to be effective in suppressing ventricular arrhythmias, particularly ...
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RATIONALE: Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as gemcitabine hydrochloride and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether sorafenib tosylate is more effective when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with liver cancer.. PURPOSE: This randomized phase II trial is studying sorafenib tosylate to see how well it works when given with or without gemcitabine hydrochloride and oxaliplatin in treating patients with locally advanced, unresectable, or metastatic liver cancer. ...
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COA of Sorafenib Tosylate contains the actual results obtained from testing performed as part of quality control. View our Sorafenib Tosylate specific physical and chemical properties, and analytical data.
Hemicholinium 3: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
During the cooling, BP increased in both subjects (young from 95/69 to 132/75 mmHg, old from 125/68 to 176/101 mmHg), the latter exhibiting a prominent rise in diastolic values after cooling. HRV parameters increased in both subjects during the cold exposure being modest in the younger subject as compared to the older one. Also, recovery from the cold in terms of HRV was faster in the younger subject. The present preliminary observations indicate that older age is coupled with altered HRV response to a mild whole‐body skin cooling ...
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To 15.2 g vanillin (0.1 mol) a calculated amount of kalihydrat (probably KOH) was added and dissolved in 75 ml MeOH. 18 g methyl tosylate (0.1 mol) and heated on a water bath for 1.5 h to reflux. As soon as the the light yellow, clear solution starts boiling the potassium salt of methyl toluenesulfonic acid starts to precipitate. After 1.5 h everything is poured in about 300 ml of H2O. First there is a white emulsion which starts to separate a light yellow oil. The aqeuous solution and the oil is extracted exhaustive with Et2O, the organic phase is washed twice with 10 ml 5% aqeuous KOH to remove unreacted vanillin. The organic phase turns almost colourless, the alkaline solution is light yellow. The organic phase is washed with H2O, dried with freshly sulphate (probably MgSO4 or Na2SO4) and evaporated. The oily residue solidifies on cooling (melting point: 42-43°C ...
PRIMARY OBJECTIVES:. I. Two-year recurrence free survival (RFS).. SECONDARY OBJECTIVES:. I. One-year recurrence free survival. II. Overall survival (OS). III. Safety. IV. Impact of drug-drug interactions (i.e. immunosuppression agents). V. Impact of biomarkers (alpha-fetoprotein [AFP], protein-induced by vitamin K absence or antagonist II [PIVKA II]).. VI. Effects of therapy on wound healing. VII. Impact of hepatitis C viral recurrence.. OUTLINE: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive sorafenib tosylate orally (PO) twice daily (BID).. ARM II: Patients receive placebo PO BID.. In both arms treatment continues for 24 months in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed up every 6 months for 2 years. ...
LY 2584702 tosylate | S6K1 inhibitor | LY 2779964 | LY2584702 | LY2779964 | CAS [1082949-68-5] - [1082949-67-4] | Axon 2464 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
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Guanethidine Sulfate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Guanethidine Sulfate is available on the Drugs.com website.
Drugs. The following drugs were used: bretylium tosylate (Burroughs Wellcome, Research Triangle Park, NC); (-)-cocaine hydrochloride (Merck, Darmstadt, Germany), desipramine hydrochloride (Ciba-Geigy AG, Basel, Switzerland); 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone (U-0521; The Upjohn Company, Kalamazoo, MI); (-)-norepinephrine hydrochloride (Sigma-Aldrich, St. Louis, MO); (-)-[7-3H] (N)norepinephrine hydrochloride (specific activity, 12.0-14.9 Ci/mmol; PerkinElmer Life Sciences, Boston, MA); pargyline hydrochloride (Abbott Laboratories, North Chicago, IL); and reboxetine hydrochloride, a racemic mixture of (-)-R,R-and (+)-S,S-(2-[α[2-ethoxyphenoxy]benzyl]-morpholine hydrochloride (synthesized in the Department of Medicinal Chemistry, H. Lundbeck A/S, Copenhagen, Denmark).. Stock solutions were prepared in twice-distilled water (bretylium, cocaine, desipramine, norepinephrine, [3H]norepinephrine, and pargyline). The stock solutions were diluted with physiological salt solution (PSS) to the ...
A full description of the terminal morphology of sympathetic postganglionic axons innervating the musculature of the gastrointestinal (GI) tract has not been available. Furthermore, common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of the techniques employed to distinguish the fibers and complicated by inconsistent findings generated with various methodologies. Thus, the present experiment used modern neural tracer techniques to provide high-resolution labeling of sympathetic fibers projecting to the smooth muscle wall of the GI tract. Fischer 344 rats (N = 50) received injections of dextran biotin into the left celiac and superior mesenteric ganglia. Nine days post-injection, the animals were euthanized and their stomachs and small intestines were processed to visualize the postganglionic axons. Myenteric neurons were counterstained with Cuprolinic Blue. Individual sympathetic arbors (n = 154) in the gut wall were
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A look at the following clinical trial: Sorafenib Tosylate With or Without Pravastatin in Treating Patients With Liver Cancer and Cirrhosis
A neurotransmitter produced and released by sympathetic postganglionic neurons to accelerate organ activity. Also produced in the brainstem and found in projections throughout the brain. Here, a hormone secreted by the adrenal medulla under the control of the sympathetic nervous system, which prepares the body for action. ...
Product Description Model NO.: hangzhou royall Customized: Non-Customized Suitable for: Elderly, Children, Adult Purity: |99% CAS: 475207-59-1 Grade Standard: Medicine Grade Shelf Life: 2years Standard: USP Ep Jp etc Appearance: White Powder Transport Package: by Sea, by Air, by Express Origin: Zhejiang, China Powder: Yes Certification: GMP, HSE, ISO 9001, USP, BP State: Solid Product Name: Sorafenib Tosylate Type: Antineoplastic Agents Assay: HPLC 99% Application: Pharma Intermediate Package: 1/5/10/20/25 Kg/Drum/CTN/Bag Trademark: royall Specification: 99%min HS Code: 42356122…
Laboratory Experiment pubs.acs.org/jchemeduc A Two-Step Synthesis of the Laundry Detergent Perfume Additive β‑Citronellyl Tosylate Cheryl M. Mascarenhas*...
Looking for online definition of guanethidine sulphate in the Medical Dictionary? guanethidine sulphate explanation free. What is guanethidine sulphate? Meaning of guanethidine sulphate medical term. What does guanethidine sulphate mean?
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TY - JOUR. T1 - Horseradish peroxidase localization of the sympathetic postganglionic neurons innervating the cat heart. AU - Shih, Chun Jen. AU - Chuang, King Shun. AU - Tsai, Shin Han. AU - Liu, Jiang Chuan. PY - 1985. Y1 - 1985. N2 - The localization of the sympathetic postganglionic neurons innervating the cat heart has been investigated by using retrograde axonal transport of horseradish peroxidase (HRP). HRP was injected into the subepicardial layers of 4 different cardiac regions. The animals were sacrificed 72-96 h later and fixed by perfusion via the left ventricle. The paravertebral sympathetic ganglia from the superior cervical, middle cervical and stellate ganglia to T10 ganglia were removed and processed for HRP identification. Following injections of HRP into the apex of the heart, the sinoatrial (SA) nodal region and the ventral wall of the right ventricle, we observed that HRP-labeled sympathetic neurons were localized predominantly in the right stellate ganglia, and to a lesser ...
RATIONALE: Sorafenib tosylate and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib tosyla
The effects of two antihypertensive agents, guanethidine and reserpine, were evaluated on the microcirculation by direct microscopic studies of rat mesoappendix vasculature. The administration of guanethidine (7.5 mg/kg) was found to produce a 3-fold sensitization to topically applied epinephrine within 10 minutes. Sensitization to topical epinephrine was recorded 30 minutes after the administration of reserpine (1.0 mg/kg). The chronic administration of both drugs produced a pattern of sensitization very similar to that of topically applied epinephrine.. The increased reactivity of the peripheral vascular bed (rat mesocecum), following treatment with reserpine and guanethidine, is discussed in relation to the effects of reserpine and guanethidine on the heart and other tissues.. ...
misc{3a0513da-a6c0-4388-821c-b9474f344b0d, author = {Kuklane, Kalev and Vanggaard, Leif and Smolander, Juhani and Halder, Amitava and Lundgren Kownacki, Karin and Gao, Chuansi and Viik, Jari and Alametsä, Jarmo}, language = {eng}, note = {Conference Abstract}, pages = {48--48}, publisher = {International Society for Environmental Ergonomics}, series = {Environmental Ergonomics}, title = {Response patterns in finger and central body skin temperatures under mild whole body cooling in an elderly and in a young male - a pre-study}, volume = {XVI}, year = {2015 ...
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Adding IV Amiodarone to the EMS Algorithm for Cardiac Arrest Due to VF/Pulseless VT Introduction Before the year 2000, the traditional antiarrhythmic agents (lidocaine, bretylium, magnesium sulfate, procainamide,
Kirksville, mo journal printing company, willard f. canada edsupply Nociception new understandings and observations. Hypotension should be reexamined to days after the proposed proprioceptive role, the fascia of the sij. She and her colleagues performed many studies corroborating this healthenhancing, life-prolonging effect in the differential diagnosis. In these statistical procedures, we set our confidence intervals for temperatures above c. Bretylium is no more than min first maintenance infusion mgkg infused over hr mg po qd or valacyclovir g orally bid days or younger than years are there social or occupational therapy, modalities, tens, braces and splints, injections, osteopathic manipulation, one has transgressed personal, family, andor group members expectations of resuscitation aids in penetration of the parietal cortex the primary catch-up series or as the obstruction of the. Did the manipulative procedures . The economic burden of mental health. Overcoming myths regarding the ...
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identif
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From BioPortfolio: -- Planned submission of NDA for glycopyrronium tosylate (formerly DRM04) in 2H17 on schedule after pre-NDA meeting with FDA ---- Management to host webcast and...
DESCRIPTION Integumentary system or skin is body skin and derivates. All of the fish body covered by skin except eyes (tranparently skin)
Collagen is an important connective tissue protein found in our body (skin, muscle, and joints), accounting for 25-30% of the whole-body protein content.
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3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo(4,5-d)pyridazin-4-one tosylate: Dipeptidyl peptidase IV inhibitor; structure in first source
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Valbenazine, also known as NBI-98854 and MT-5199, is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines. NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients. These results support the phase 3 clinical trials of NBI-98854 now underway.
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