Breast cancer brain metastases (BCBM) develop in about 20-30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of valuable molecular therapeutic targets. The aim of the study was to identify new molecular biomarkers and targets in BCBM by using complementary state-of-the-art techniques. We compared array expression profiles of three BCBM with 16 non-brain metastatic BC and 16 primary brain tumors (prBT) using a false discovery rate (FDR) p | 0.05 and fold change (FC) | 2. Biofunctional analysis was conducted on the differentially expressed probe sets. High-density arrays were employed to detect copy number variations (CNVs) and whole exome sequencing (WES) with paired-end reads of 150 bp was utilized to detect gene mutations in the three BCBM. The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1,
TY - JOUR. T1 - Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models. AU - Jun, Kyong Hwa. AU - Lee, Jung Eun. AU - Kim, Se Hoon. AU - Jung, Ji Han. AU - Choi, Hyun Joo. AU - Kim, Young Il. AU - Chin, Hyung Min. AU - Yang, Seung Ho. PY - 2015/10/1. Y1 - 2015/10/1. N2 - Gastric cancer is the second most common cause of cancer-related death worldwide. Although brain metastasis is a rare complication of gastric cancer, no standard therapy for gastric cancer brain metastasis has been established. We attempted to identify biological markers that predict brain metastasis, and investigated how to modulate such markers. A case-control study of patients newly diagnosed with gastric cancer who had developed brain metastasis during follow-up, was conducted. These patients were compared with patients who had advanced gastric cancer but no evidence of brain metastasis. Immunohistochemistry was used to analyze ...
Central nervous system imaging is needed during programmed death 1 (PD-1) inhibitor therapy to monitor incidence, patterns of progression, and outcomes of melanoma brain metastases, according to research presented at the 2017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).. -----. Related Content. Ipilimumab Combination Significantly Improves Melanoma Outcomes. Skip whole-brain radiation in patients with limited brain metastases. -----. Metastases in the brain is a common occurrence for patients with metastatic melanoma. Currently available therapies are often unable to treat metastatic melanoma tumors in the brain. Limited data exists concerning the incidence, patterns of progression, and outcomes of patients with melanoma brain metastasis treated with PD-1 inhibitors, particularly in conjunction with central nervous system-focused therapy.. Gustavo Schvartsman, MD, MD Anderson Cancer Center (Houston, TX), and colleagues retrospectively reviewed the survival outcomes of patients with ...
June 19, 2020 - Imaging Biometrics, LLC (IB), a subsidiary of IQ-AI Limited and a recognized leader in quantitative imaging analysis for brain tumor diagnosis and treatment, today announced that the MRI DSC perfusion technology, first made commercially available in IB Neuro, earned recognition as the national standard for use in high-grade brain tumors. This recognition was the outcome of the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition. The Committees findings, published in Neuro Oncology (Consensus Recommendations for a DSC MRI Protocol), provide evidence-based best practices for routine clinical use from both an MR acquisition and post-processing perspective. DSC, which stands for dynamic susceptibility contrast, is the most common perfusion MRI technology used for the evaluation of brain tumors. This national consensus is long overdue. Despite its widespread use, MRI-DSC imaging has been plagued by inconsistent and suboptimal ways of ...
A metastatic, or secondary, brain tumor is one that begins as cancer in another part of the body. Some of the cancer cells may be carried to the brain by the blood or lymphatic fluid, or may spread from adjacent tissue. The site where the cancerous cells originated is referred to as the primary cancer. Metastatic brain tumors are often referred to as lesions or brain metastases. Metastatic brain tumors are the most common brain tumors. There has been an increase in metastatic lesions as people are surviving primary cancers for longer periods of time ...
TY - JOUR. T1 - Visionary approach for the treatment of brain tumors. AU - Yoshimoto, Koji. AU - Kada, Akiko. AU - Hatae, Ryusuke. AU - Murata, Hideki. AU - Akagi, Yojiro. AU - Nishimura, Kunihiro. AU - Mizoguchi, Masahiro. AU - Iihara, Koji. PY - 2015/10/25. Y1 - 2015/10/25. N2 - To investigate patient background and current trends in the treatment of brain tumor patients, we analyzed a patient dataset using the Diagnosis Procedure Combination(DPC) database. The DPC data of all inpatients treated between April 2013 and March 2014 in the 327 core and branch hospitals enrolled in the Japan Neurosurgical Society training program were collected. Using ICD-10 code, we could extract 6,142 primary malignant brain tumor patients, 2,538 secondary malignant brain tumor patients, 2,043 pituitary tumor patients, 3,854 meningioma patients, and 5,666 other benign brain tumor patients from amongst a total of 501,609 patients. In this study, we focused on the primary and secondary malignant brain tumor ...
Patients with surgically removed single brain metastasis are randomly allocated to control or experimental arm. Before treatment the MRC Neurological Status Scale is used for assessing neurological status, the EORTC QLQ-C30 and QLQ-BN20 for quality of life and Mini-Mental State Examination to assess cognitive functioning. The control group receive 30Gy in 10 fractions of 3Gy over 12 days to the whole brain. The patients in the experimental arm are treated with stereotactic radiotherapy to the resection cavity. The dose to the tumor bed is 15-18Gy in one fraction or 25Gy in 5 fractions. The study hypothesis is that the difference in the 5-months failure free survival rate isnt higher than 25% in experimental arm compared to control arm ...
Patients with surgically removed single brain metastasis are randomly allocated to control or experimental arm. Before treatment the MRC Neurological Status Scale is used for assessing neurological status, the EORTC QLQ-C30 and QLQ-BN20 for quality of life and Mini-Mental State Examination to assess cognitive functioning. The control group receive 30Gy in 10 fractions of 3Gy over 12 days to the whole brain. The patients in the experimental arm are treated with stereotactic radiotherapy to the resection cavity. The dose to the tumor bed is 15-18Gy in one fraction or 25Gy in 5 fractions. The study hypothesis is that the difference in the 5-months failure free survival rate isnt higher than 25% in experimental arm compared to control arm ...
Pediatric brain tumors are masses or growths of abnormal cells that occur in the brain or the tissue and structures that are near it. Many different types of pediatric brain tumors exist. Some pediatric brain tumors are noncancerous (benign), and some pediatric brain tumors are cancerous (malignant).
Pediatric brain cancer is one of the most common forms of disease diagnosed in children. Market Research Future, a firm which specializes in market reports related to the healthcare sector among others, published in its recent report on Pediatric Brain Tumor Market Research Report - Global Forecast till 2023, that the global pediatric brain tumor market is growing at the CAGR of 4.1% during the forecast period and expected to reach US$ 1659.4 million by 2023. Increasing incidences of pediatric brain tumor are being identified around the world which has contributed gradually to the growth of the market.. The main causative factor for pediatric brain tumor market is genetics. Most of the tumors are diagnosed after child birth till 12 years of age, which is usually detected after appearance of certain symptoms. Due to the appearance of additional types of mutations in terms of pediatric brain tumor, the scope of the market has widened significantly. Most of the tumors currently known in this ...
Series Editor: Arthur T. Skarin, MD, FACP, FCCP Systemic cancer can affect the central nervous system in several different ways, including direct tumor metastasis and indirect remote effects. Intracranial metastasis can involve the skull, dura, and leptomeninges (arachnoid and pia mater), as well as the brain parenchyma. Of these, parenchymal brain metastases are the most common and have been found in as many as 24% of cancer patients in autopsy studies. It has been reported that metastatic brain tumors outnumber primary brain tumors 10 to 1. To read the full article in PDF: Click here ...
Side Effects of Whole Brain Radiation. The initial approach to using radiation postoperatively to treat brain metastases, used to be whole brain radiation, but this was abandoned because of the substantial neurological deficits that resulted, sometimes appearing a considerable time after treatment. Whole brain radiation was routinely administered to patients after craniotomy for excision of a cerebral metastasis in an attempt to destroy any residual cancer cells at the surgical site. However, the deleterious effects of whole brain radiation, such as dementia and other irreversible neurotoxicities, became evident. This raised the question as to whether elective postoperative whole brain radiation should be administered to patients after excision of a solitary brain metastasis. Current clinical practice, at most leading cancer centers, use a more focused radiation field that includes only 2-3cm beyond the periphery of the tumor site. This may involve therapy once a day for about six weeks and ...
2814 An estimated 30% of breast cancer patients have metastases to the brain and no effective treatment is yet available. Breast cancer brain metastases flourishes under the brains highly vascularized microenvironment, which provides nutrients and oxygen to the tumor. The purpose of this study was to analyze the functional properties of endothelial cells derived from metastatic breast cancer to the brain (BBEC). BBEC were isolated from brain tissue specimens of a patient with advanced breast cancer brain metastases. Primary cultures of human BBEC were purified using flow cytometry and characterized as endothelial cells based on positive immunostaining for Factor VIII, CD31, and CD105. BBEC are morphologically larger and more flattened than normal brain endothelial cells (BEC). A functional analysis of BBEC demonstrate that these cells proliferate more slowly than the BEC, and exhibit a significantly higher expression of the proangiogenic growth factors: vascular endothelial growth factor ...
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Pediatric brain tumors are abnormal growths that arise in the brain during childhood. Several treatment options are available, including close observation, surgery, radiation therapy and chemotherapy. Although brain tumors are rare overall, they are the most common solid tumor among children. Whats important to remember is that children are not simply miniature adults. Brain tumors in children behave differently than brain tumors in adults. Whats more, children require treatment that is tailored not just to their tumor type, but also to their age and development. At the Pediatric Neurosurgery Center, we are committed to meeting the special needs of young patients and their families. Pediatric brain tumors can be either benign or malignant. Malignant, or cancerous, tumors tend to be fast-growing and aggressive, invading surrounding brain tissue. Benign tumors are not cancerous; they do not spread and they tend to be slow-growing. Even slow-growing benign brain tumors can eventually become ...
Wockhardt Hospitals provides brain tumor treatment for international patients from around the world whilst ensuring excellent international patient care. Visit us to know more about the brain tumor surgery in India.
A brain tumor is an abnormal growth of tissue in the brain. The tumor can either originate in the brain itself (primary brain tumor), or come from another part of the body and travel to the brain (metastastic or secondary brain tumor). Brain tumors may be classified as either benign (noncancerous) or malignant (cancerous), depending on their behavior.. A benign tumor does not contain cancer cells and usually, once removed, does not recur. Most benign brain tumors have clear borders, meaning they do not invade surrounding tissue. These tumors can, however, cause symptoms similar to cancerous tumors because of their size and location in the brain.. Malignant brain tumors contain cancer cells. Malignant brain tumors are usually fast growing and invade surrounding tissue. Malignant brain tumors very rarely spread to other areas of the body, but may recur after treatment. Sometimes, brain tumors that are not cancer are called malignant because of their size and location, and the damage they can do to ...
TY - JOUR. T1 - Brain tumor patients with impaired cognitive flexibility do not efficiently update functional connectivity within the fronto-parietal network. AU - De Baene, Wouter. AU - Jansma, J.M.. AU - Rutten, Geert-Jan. AU - Sitskoorn, Margriet. PY - 2018. Y1 - 2018. N2 - Background The majority of brain tumor patients suffers from cognitive deficits. These deficits can be very disruptive for a persons daily functioning, quality of life and treatment compliance. Examining functional connectivity patterns during the performance of a cognitive task may enhance our understanding of the relationship between functional brain networks and cognitive performance. Despite the similarity in network topology across rest and task states, there are also meaningful differences in functional connectivity that are likely to be linked to cognitive performance. Currently, it is largely unknown how differences between rest and task functional connectivity patterns are related to cognitive functioning in ...
TY - JOUR. T1 - Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain. AU - Tseng, Sheng Hong. AU - Hsieh, Chia Ling. AU - Lin, Swei Ming. AU - Hwang, Lih Hwa. PY - 1999. Y1 - 1999. N2 - This study investigated the therapeutic effects of a rat glioma cell line, C6, that was engineered to secrete mouse GM-CSF (mGM-CSF) on intracerebral (i.c.) brain tumors. Significant antitumor immunity was induced in rats when the live or irradiated mGM-CSF-secreting tumor vaccine was implanted i.c. The antitumor activity was effective on small tumors and, to a lesser extent, on large tumors or tumors existing in vivo for a longer duration, Immunohistochemical analysis revealed cellular infiltrates (granulocytes, macrophages, and CD4+ and CD8+ T cells) at both the vaccine site and the tumor site, indicating that immune responses were similarly activated when tumor vaccine was inoculated in the brain, as at the subcutis. Additional studies demonstrated that the therapeutic ...
Los Angeles - March 22, 2006 - In a study published in the March 15 issue of The Journal of Immunology, researchers at Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have developed a way to overcome immune privilege in the brain to eradicate potentially deadly brain tumors such as glioblastoma multiforme and other types of brain infections.. Brain tumors account for 85 to 90 percent of all primary central nervous system tumors. Of those tumors, almost 40 percent are either the deadly glioblastoma multiforme or anaplastic astrocytomas. Each year about 19,000 people in the United States are diagnosed with primary brain cancers, and close to 70 percent of those diagnosed will not survive more than five years. In addition, approximately 150,000 Americans a year are diagnosed with metastatic brain tumors, cancer that has spread into the brain from another part of the body.. "We have developed a novel gene therapy strategy to modify the brain microenvironment ...
TY - JOUR. T1 - An instrument for estimating the 6-month survival probability after whole-brain irradiation alone for cerebral metastases from gynecological cancer. AU - Janssen, Stefan. AU - Hansen, Heinke C.. AU - Schild, Steven E.. AU - Rades, Dirk. PY - 2018/6/1. Y1 - 2018/6/1. N2 - Background/Aim: Patients with cerebral metastases from gynecological cancer who receive whole-brain irradiation (WBI) alone require personalized therapy. This study contributes to personalized care by creating an instrument to predict 6-month survival probability. Patients and Methods: In 49 patients, six pre-treatment variables, namely age, Eastern Cooperative Oncology Group performance score (ECOG-PS), primary tumor type, number of cerebral metastases, metastasis outside the brain, and interval between diagnosis of gynecological cancer and WBI, were analyzed for survival. Results: Of the six pre-treatment variables, ECOG-PS was significantly associated with survival (p=0.014) and metastasis outside the brain ...
Munich, February 3, 2017-In support of World Cancer Day 2017, which aims to bring global attention to cancer, Brainlab, a leader in cancer-fighting technologies, raises awareness about metastatic brain cancer and the revolutionary new methods being used to treat the disease. According to the World Health Organization (WHO), 14 million new cases of cancer are diagnosed every year, with that number expected to rise by 70% over the next two decades. Cancers of the lung, breast, skin, colon and kidney present the highest risk of metastasizing to the brain.. As treatments improve, in combination with early detection, cancer patients are living longer, resulting in higher incidence of brain metastases, according to the American Brain Tumor Association (ABTA). One of the most prevalent procedures for treating multiple brain metastases is whole brain radiation therapy (WBRT) despite increasing evidence that WBRT can lead to significant cognitive side effects and the existence of alternative, less severe ...
Brain is used for almost every function of the body. It is related to the work of most of the parts. It controls and coordinates the actions and allows us to think and feel. It processes information that is received from different parts of the body and the way how we react is dependent on brain only. It is considered as the most complex organ in the body. It consists of billions of neurons which are connected by synapses to several other neurons. There are some conditions and disorders related to this part which stops it from working properly and affect the whole body. Brain tumor is one of those conditions. Brain tumor treatment hospital in India diagnoses the symptoms and treats according to the severity of the condition.. It is the condition in which there is growth of abnormal cells or mass in the brain. Tumors are of different types. They can either be benign which means they are non cancerous or can be malignant which means they have the potential to spread to different parts of the body. ...
|i|Objectives.|/i| Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard |sup|18|/sup|F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism.|i| Methods.|/i| Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO|sub|2|/sub|) and glucose (CMRGlu) metabolism, and AG, using |sup|15|/sup|O-labeled CO, O|sub|2|/sub| and H|sub|2|/sub|O, and FDG, and were compared to a normative cohort of 20 age-matched individuals.|i| Results.|/i| Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO|sub|2|/sub| and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased
Brain tumour treatment depends on various factors, such as size and location of the tumour, as well as the patients age and heath. The treatment options are differs for adults and children. Visit here to know more.
This neurosurgeon and neuroradiologist team will determine whether a new non-invasive MRI imaging technique can reveal innate immune cells presence in deadly brain tumors in children and adults, and can be used to assess responses to an experimental immunotherapy that is soon to undergo human clinical testing. Prognoses for malignant brain tumors in children and adults remain stubbornly poor, with a life expectancy of about one year, despite decades of vigorous research on experimental treatments. Prior research has demonstrated that innate (first line of defense) immune cells called "macrophages" infiltrate brain tumors; in fact, they make up 30-70 percent of brain tumor tissue. The degree of macrophage infiltration has been found to relate to overall survival in a few types of cancers including breast cancers and Hodgkins lymphoma, and in a type of brain tumor called malignant-astrocytoma. Despite the abundant macrophage presence in brain tumors, no current immunotherapy has employed the use ...
Thesis, English, role of magnetic resonance spectroscopy in differentiation between recurrent brain neoplasms versus postradiation effects for Amin Mai Hafez Abbas
Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide Mark R Gilbert1, Terri S Armstrong21Department of Neuro-Oncology, The University of Texas MD, Anderson Cancer Center, Houston, TX, USA; 2Department of Integrated Nursing Care, University of Texas Science Center â School of Nursing, Houston, TX, USAAbstract: The prognosis for patients with newly diagnosed malignant gliomas remains poor; however there have been some recent advances in treatment that have generated optimism. Medical management usually includes administration of corticosteroids to control peritumoral edema. Anticonvulsants are indicated for patients with established tumor-related seizures; however, the prophylactic use of anticonvulsants remains controversial. Advances in neurosurgical techniques have improved the safety of tumor resection and most patients undergo the maximal safe surgical debulking of tumor. The tissue sample obtained provides conclusive
Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC. Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors. Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and
Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC. Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors. Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and
metastatic brain tumors are malignant.. - Primary brain tumors - gliomas. About 80% of primary malignant brain tumors known as gliomas.It is not any particular type of cancer, but the term is used to describe tumors that arise from glial cells (glia or glial cells - These cells surround nerve cells and play a supportive role, glial cells, except microglia have common features and some common origin,they constitute microenvironment specific to neurons, providing conditions for the transmission of nerve impulses).Glial cells are the building blocks of the connective tissue or supporting cells in the central nervous system (CNS).. gliomas are divided into four classes, which reflect the degree of malignancy.Classes (degree) I and II are considered low-grade, and classes III and IV - full-fledged.Classes I and II - with the slowest and least malignant.Class III malignant tumors and is considered to grow at a moderate rate.Class IV malignant - tumor such as glioblastoma, the most rapidly growing and ...
Treatment depends on the size and type of the tumor, from where in the body it spread, and the persons general health. The goals of treatment may be to relieve symptoms, improve functioning, or provide comfort.. Radiation to the whole brain is often used to treat tumors that have spread to the brain, especially if there are many tumors.. Surgery may be used when there is a single tumor and the cancer has not spread to other parts of the body. Some tumors may be completely removed. Tumors that are deep or that extend into brain tissue may be reduced in size (debulked).. Surgery may reduce pressure and relieve symptoms in cases when the tumor cannot be removed.. Chemotherapy for metastatic brain tumors is usually not as helpful as surgery or radiation. Some types of tumors, though, do respond to chemotherapy.. Stereotactic radiosurgery may also be used. This form of radiation therapy focuses high-power x-rays on a small area of the brain. It is used when there are only a few tumors.. Medicines ...
We have a closers look at the various brain tumor treatments that are currently being used in the neurological treatments table today
Pray for Gray is a local charity for brain tumors. Local woman, Julie Fletcher is the founder and a brain tumor survivor. It is an an organization filled with hope, to educate and to raise awareness of brain tumors, to help meet the needs of other brain tumor patients and their families, and to ultimately raise funds for new research and patient survival. Pray for Gray provided assistance to 67 area brain tumor families. The video is of some of our brain tumor families. The first picture is of Juie Fletcher, Founder and Executive Director and 2017 brain tumor honoree Andi Olsonawski. Proceeds Pray for Gray accumulates will go to help area brain tumor survivors and their families and ) and brain tumor research programs. Pray for Gray shares stories of people who have been affected by brain tumors, showing the reality of their existence, but yet creating an avenue for hope. Hope comes in the form of new treatments to fight this disease, a disease that affects the core of our existence; the Central
Our observed effect may have a correlation to the initial size of the lesion, as those with complete response had median initial size of 0.8 cm, while partial responders and stable responders had median initial sizes of 1.0 cm and 1.1 cm, respectively. In our descriptive comparison to patients treated with SRS and concurrent ipilimumab or with SRS without immunotherapy, the responses to SRS and pembrolizumab appeared favorable. Past studies have suggested that concurrent checkpoint blockade with CTLA-4 inhibition and SRS to brain metastases has durable local control of treated lesions [4, 5, 7], though not all reports have shown an enhanced benefit to SRS with concurrent ipilimumab [6]. In this study, we found that 93% of treated lesions were controlled at the time of death after SRS and concurrent pembrolizumab, similar to the prior reports of durable control.. Overall, pembrolizumab and brain radiation therapy appeared to have acceptable acute toxicity. Specific acute toxicities that were ...
HOUSTON--Controversy continues to shroud the issue of how single and multiple brain metastases should be treated, Moshe H. Maor, MD, said at a symposium on CNS cancer, sponsored by The University of Texas M.D. Anderson Cancer Center, where he is a radiation oncologist. 1
TY - JOUR. T1 - Loss of CADM1 expression is associated with poor prognosis and brain metastasis in breast cancer patients. AU - Wikman, H.. AU - Westphal, L.. AU - Schmid, F.. AU - Pollari, Sirkku. AU - Kropidlowski, J.. AU - Sielaff-Frimpong, B.. AU - Glatzel, M.. AU - Matschke, J.. AU - Westphal, M.. AU - Iljin, Kristiina. AU - Huhtala, H.. AU - Terraciano, L.. AU - Kallioniemi, A.. AU - Sauter, G.. AU - Müller, V.. AU - Witzel, I.. AU - Lamszus, K.. AU - Kemming, D.. AU - Pantel, K.. PY - 2014. Y1 - 2014. N2 - Breast cancer brain metastases (BCBM) are detected with increasing incidence. In order to detect potential genes involved in BCBM, we first screened for genes down-regulated by methylation in cell lines with site-specific metastatic ability. The expression of five genes, CADM1, SPARC, RECK, TNFAIP3 and CXCL14, which were also found down-regulated in gene expression profiling analyses of BCBM tissue samples, was verified by qRT-PCR in a larger patient cohort. CADM1 was chosen for ...
The intracranial compartment is a common site of metastatic cancer. Of the patients projected to die of systemic cancer approximately 25 percent, or over are expected to have intracranial metastasis. The importance of intracranial metastasis is, however, not primarily due to its frequent occurrence but to the fact that the large majority of the new foci become symptomatic. Compared with other organs, such as the lung and liver, in which the incidence of metastasis is even higher, the manifestations of metastases affecting the brain are usually more overt and disabling and if untreated, tend to be rapidly lethal. For these reasons brain metastasis demands prompt diagnostic and therapeutic attention.. A sense of frustration is justifiably inherent in the treatment of patients suffering from disseminated cancer. With few exceptions, even the eradication of a presumed solitary metastasis is followed sooner or later by the discovery of metastases elsewhere or at the primary site. Nevertheless, ...
Glioblastoma multiforme (GBM), a highly malignant primary brain tumor, is difficult to distinguish from from its surrounding functioning tissue under direct vision in the operating field, since it grows in an infiltrative growth pattern. The main challenge in the surgical treatment of GBM is to fully resect the tumor and avoid neurological impairment. In this paper we extend previous proof-of-principle studies by extending the clinical potential of OTP with the introduction of more sophisticated multivariate analysis schemes. The aim is to distinguish tumor and healthy tissue as well as possible using singular value decomposition (SVD) and cluster analysis methods.. ...
Health, ...Brain tumor specimens taken from neurosurgery cases at the University ...The work may help identify new drugs to target oligodendroglioma a co...As described in the journal Cancer Cell this month the UCSF te... This happens early before the tumor forms and it may provide a poin...,How,normal,cells,become,brain,cancers,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Benign brain tumors are often outlined as a gaggle of comparable cells that dont comply with regular cell division and progress patterns and develop right into a mass of cells that microscopically dont have the attribute look of a most cancers. Most benign brain tumors are discovered by CT or MRI brain scans.
Synonyms for Adult Brain Tumor in Free Thesaurus. Antonyms for Adult Brain Tumor. 1 synonym for brain tumor: brain tumour. What are synonyms for Adult Brain Tumor?
Objectives Diffusion-weighted imaging (DWI) may enhance the radiographic diagnosis of pediatric brain tumors. This study reviews the DWI properties of pediatric brain tumors at our institution and...
Early surgery for patients with slow-growing, low-grade glioma brain tumours may result in better survival than a wait-and-see approach.
...For patients with glioma the most common primary brain tumor new fin...The finding is significant the researchers say because it gives canc...Different life expectancies for two types of brain tumors were what fi... With treatment patients with oligodendroglioma can live many years l...,Cell,of,origin,for,brain,tumors,may,predict,response,to,therapy,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Objective: Glioma is the most common primary malignant brain tumor in adults, responsible for 75% of adult primary malignant brain tumors, yet aside from its association with ionizing radiation, its etiology is poorly understood. Sex differences in brain tumor incidence suggest that hormonal factors may play a role in the etiology of these tumors, but few studies have examined this association in
A metastatic brain tumor is a tumor of the brain that originated from elsewhere in the body. The most commonly primary tumor sites associated with brain metastatic tumors are the lung and breast, although there are many sites where the tumor may come from. In general, it is important to determine the site of origin before treating the metastatic brain tumor. Treatment often entails stereotactic radiosurgery, microsurgical resection, and/or chemotherapy. The decision on exactly how to treat each tumor is made on a individual basis; there are many important factors that guide treatment. A few of these factors are the type of tumor (for example, originating from the lung), the location, the size, and the state of tumors in other parts of the body.. Read more about metastatic brain tumors on the AANS website.. ...
Neuro-oncology, Surgery on brain tumors, Spine surgery, Tumors, instability, congenital anomalies, CV junction, degenerative and trauma
BACKGROUND: Microglia/macrophages (M/Ms) with multiple functions derived from distinct activation states are key surveillants maintaining brain homeostasis. However, their activation status and role during the brain metastasis of malignant tumors have been poorly characterized. METHODS: Heterozygous CX3CR1-GFP transgenic mice were used to visualize the dynamic changes of M/Ms during the development of experimental brain metastasis through long-term intravital imaging equipped with redesigned bilateral cranial windows. The occurrence of experimental brain metastasis was evaluated after M/Ms were depleted with PLX3397, a CSF-1R inhibitor. The possible mediators of M/Ms in facilitating the brain metastasis were determined using reverse transcription-PCR, immunofluorescence, correlational analysis, and MMP inhibition. RESULTS: Here, we showed that M/Ms were persistently activated and facilitated the formation of melanoma brain metastasis in vivo. We observed that M/Ms gradually and massively ...
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