Title:18FDG-PET/CT in Traumatic Brain Injury Patients: The Relative Hypermetabolism of Vermis Cerebelli as a Medium and Long Term Predictor of Outcome. VOLUME: 7 ISSUE: 1. Author(s):Andrea Lupi, Giannettore Bertagnoni, Anna Borghero, Alessandro Picelli, Vincenzo Cuccurullo and Pierluigi Zanco. Affiliation:Division of Nuclear Medicine, Ospedale "S. Bortolo" - Via M. Rodolfi, 36100 Vicenza - ITALY.. Keywords:Brain trauma, imaging, prognosis, vermis cerebelli.. Abstract:Purpose: Both, the constant presence of apparent hypermetabolism of the vermis cerebelli compared to the cerebellar hemispheres in traumatic brain injury, and the presence of a good relationship between the intensity of this sign and the severity of the clinical conditions have been addressed in previous studies. Aim of the present paper is to evaluate the possible correlation between the intensity of the finding and the medium and long term outcome in a group of patients. Materials and Methods: A group of 105 patients consecutively ...
The Centers for Disease Control and Prevention (CDC), along with Rep Bill Pascrell (D-NJ) and Sen Robert Menendez (D-NJ), recently announced that CDC will form an expert panel to establish national guidelines for pediatric traumatic brain injury and concussion. This initiative was a major component of the Concussion Treatment and Care Tools (ConTACT) Act, legislation that was not passed into law but was supported by APTA in past congressional sessions. This announcement marks a positive step forward by the federal government through a united commitment by Congress and the Department of Health and Human Services to address the important issue of concussion management. The expert panel will define the need, scope, and expectations of federal guidelines for pediatric mild traumatic brain injury, including those for student athletes. The national guidelines will take into account advice from experts across the country, laying the foundation for all 50 states to implement a standard and protect young ...
The Brain Trauma Foundation is presenting a free webinar on Assessment & Prognosis in Severe Traumatic Brain Injury on Wednesday, April 25, 2012, 12-1 Eastern Time. This webinar is open to all. Survivors of severe traumatic brain injury face a wide range of possible prognoses, from nearly complete recovery to permanent unconsciousness. The ability to predict prognosis at an early point is limited, but the time until return of consciousness (e.g., command following) and orientation (e.g., duration of post-traumatic amnesia) are useful predictors in the early days and weeks. More specialized assessment techniques exist of those with persistent disorders of...
1 Botulinum Toxin Type A Treatment For Traumatic Brain Injury-Induced Jaw-Opening Oromandibular Dystonia Karen Gisotti DO 1, Scott Fuchs DO 1, Gilbert Siu DO PhD 1, Sooja Cho MD 2, C.R. Sridhara MD 1,2 1 Department of Physical Medicine & Rehabilitation, Temple University Hospital, Philadelphia, PA 2 MossRehab, Elkins Park, PA ABSTRACT Setting: Tertiary care rehabilitation center and electrodiagnostic laboratory Patient: 18-year-old female with severe traumatic brain injury. Case: 18-year-old female with severe traumatic brain injury due to a motor vehicle collision who sustained a right subdural hematoma and diffuse axonal injury along with right orbital and mandible fractures and remained minimally responsive at admission. She had upper motor neuron syndrome, severe spasticity, and hyperreflexia with minimal voluntary control. The patient also presented with severe jaw-closing impairment, which affected her oral hygiene, swallowing mobility, and speech presentation. Electrodiagnostic studies ...
About: Predicting Seizures In The Acute Stage Of Pediatric Traumatic Brain Injury. Blog by a compassionate yet aggressive San Francisco Injury Attorney.
Content for ASHAs Practice Portal is developed through a comprehensive process that includes multiple rounds of subject matter expert input and review. ASHA extends its gratitude to the following subject matter experts who were involved in the development of the Pediatric Traumatic Brain Injury page. ...
TY - JOUR. T1 - Prevalence of Medical and Psychiatric Comorbidities Following Traumatic Brain Injury. AU - Hammond, Flora M.. AU - Corrigan, John D.. AU - Ketchum, Jessica M.. AU - Malec, James F.. AU - Dams-OConnor, Kristen. AU - Hart, Tessa. AU - Novack, Thomas A.. AU - Bogner, Jennifer. AU - Dahdah, Marie N.. AU - Whiteneck, Gale G.. PY - 2019/7/1. Y1 - 2019/7/1. N2 - Objective: To examine the prevalence of selected medical and psychiatric comorbidities that existed prior to or up to 10 years following traumatic brain injury (TBI) requiring acute rehabilitation. Design: Retrospective cohort. Setting: Six TBI Model Systems (TBIMS) centers. Participants: In total, 404 participants in the TBIMS National Database who experienced TBI 10 years prior. Interventions: Not applicable. Main Outcome Measure: Self-reported medical and psychiatric comorbidities and the onset time of each endorsed comorbidity. Results: At 10 years postinjury, the most common comorbidities developing postinjury, in order, ...
TY - JOUR. T1 - Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. AU - McAllister, Thomas W.. AU - Rhodes, C. Harker. AU - Flashman, Laura A.. AU - McDonald, Brenna C.. AU - Belloni, Dorothy. AU - Saykin, Andrew J.. PY - 2005/9/1. Y1 - 2005/9/1. N2 - Objective: The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury. Method: Thirty-nine patients with mild traumatic brain injury and 27 comparison subjects were genotyped. All subjects completed memory and attention tests, including the California Verbal Learning Test recognition task and the Continuous Performance Test. Results: In both groups the T allele was associated with poorer performance on the California Verbal Learning Test recognition task. There was also a significant diagnosis-by-allele interaction on measures of response ...
What is a brain injury? Brain injury can be defined as a type of head injury that is caused by rapid acceleration and deceleration of the head during which the brain bounces off the inside of the skull. Brain injury can also be caused by a car accident, gunshot wound, or other external factor. What are the different types of brain injuries? There are many different types of brain injuries with varying levels of severity. The different types of brain injuries are: Traumatic Brain Injury (TBI), Acquired Brain Injury, Open Brain Injury, and Closed Brain Injury. An Anoxic brain injury occurs when the oxygen supply is somehow cut off, and can cause serious and irreversible damage if it\s interrupted for even just a few minutes. What are the most common causes of brain injury? Some of the most common causes of brain injury include car accidents, motorcycle accidents, slip-and-fall accidents, gunshots, stabbings, and pedestrian accidents. This also varies according to an age group, as young children ...
TY - JOUR. T1 - Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children. T2 - Association with severity of injury and excitotoxicity. AU - Robertson, Courtney. AU - Bell, M. J.. AU - Kochanek, P. M.. AU - Adelson, P. D.. AU - Ruppel, R. A.. AU - Carcillo, J. A.. AU - Wisniewski, S. R.. AU - Mi, Z.. AU - Janesko, K. L.. AU - Clark, R. S B. AU - Marion, D. W.. AU - Graham, S. H.. AU - Jackson, E. K.. PY - 2001. Y1 - 2001. N2 - Objectives: To measure adenosine concentration in the cerebrospinal fluid of infants and children after severe traumatic brain injury and to evaluate the contribution of patient age, Glasgow Coma Scale score, mechanism of injury, Glasgow Outcome Score, and time after injury to cerebrospinal fluid adenosine concentrations. To evaluate the relationship between cerebrospinal fluid adenosine and glutamate concentrations in this population. Design: Prospective survey. Setting: Pediatric intensive care unit in a university-based ...
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The Traumatic Brain Injury Model System (TBIMS) program was created and funded by the National Institute on Disability and Rehabilitation Research (NIDRR) in 1987 to demonstrate the benefits of a coordinated system of neurotrauma and rehabilitation care and conduct innovative research on all aspects of care for those who sustain traumatic brain injuries. Each Center systematically collects important data about each individual who meets criteria for inclusion in the TBI National Database and sends this information to the TBI National Data Center at KMRREC. The Centers are currently located at 16 sites throughout the United States that provide comprehensive systems of brain injury care to individuals who sustain a traumatic brain injury, from acute care through community re-entry. The mission of the TBIMS is to improve the lives of persons who experience traumatic brain injury, their families and communities by creating and disseminating new knowledge about the course, treatment and outcomes relating to
From the age of five through adulthood, trauma is the leading cause of death, and many traumatic injuries involve brain injury. Fortunately, the majority of traumatic brain injuries are mild, but nevertheless, some children will experience a severe traumatic brain injury.
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17, 10-13. Haarbauer-Krupa, J. (2012b). Taking care of children after traumatic brain injury. Perspectives on School-Based Issues, 13, 79-86. Halstead, M. E., McAvoy, K., Devore, C. D., Carl, R., Lee, M., Logan, K., . . . LaBella, C. R. (2013). Returning to learning following a concussion. Pediatrics, 132, 948-957. Hickey, E. M., & Saunders, J. N. (2010). Group intervention for adolescents with chronic acquired brain injury: The future zone. Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders, 20, 111-119. Hotz, G., Castelblanco, A., Lara, I., Weiss, A., Duncan, R., & Kuluz, J. (2006). Snoezelen: A controlled multi-sensory stimulation therapy for children recovering from severe brain injury. Brain Injury, 20, 879-888. Hotz, G., Quintero, A., Crittenden, R., Baker, L., Goldstein, D., & Nedd, K. (2014). A countywide program to manage concussions in high school sports. The Sport Journal. Retrieved from ...
TY - JOUR. T1 - ACUTE GLUCOCORTICOID DEFICIENCY AND DIABETES INSIPIDUS ARE COMMON FOLLOWING ACUTE TRAUMATIC BRAIN INJURY AND PREDICT MORTALITY. AU - Hannon, M. AU - Crowley, R. AU - Behan, L. AU - OSullivan, E. AU - OBrien, M. AU - Sherlock, M. AU - Rawluk, D. AU - ODwyer, R. AU - Tormey, William. AU - Thompson, C. PY - 2013/5. Y1 - 2013/5. U2 - 10.1210/jc.2013-1555. DO - 10.1210/jc.2013-1555. M3 - Article. VL - 20. SP - 1555. JO - Journal of Clinical Endocrinology and Metabolism. JF - Journal of Clinical Endocrinology and Metabolism. SN - 0021-972X. ER - ...
CC Grand Rounds: Magnetic Resonance Imaging in Acute Traumatic Brain Injury: Identification of Novel Biomarkers and Implications for Therapy
Recovery from a mTBI can vary, however generally speaking, the severity of the mTBI will have a direct impact on the likelihood of a positive recovery. Dr Shores states, Concussion and uncomplicated mTBI generally lead to full recovery, however repeat concussions and complicated or more severe injuries can lead to long term functional impairment. Dr Shores advises caution and care when evaluating an injury, as there are dangers in both over-estimating and under-estimating brain injury severity, particularly based on duration of PTA. Duration of PTA provides a guideline to the severity of brain impairment and has been shown to be a useful outcome predictor of cognitive-behavioural-social dysfunction, with longer duration of PTA predicting a worse outcome. A careful scrutiny of the results of existing measures is necessary in determining severity of the injury. In contrast to mTBI, Moderate to Very Severe traumatic brain injuries are expected to have more permanent neurocognitive disorder than ...
Primary and secondary brain injury are ways to classify the injury processes that occur in brain injury. In traumatic brain injury (TBI), primary brain injury occurs during the initial insult, and results from displacement of the physical structures of the brain. Secondary brain injury occurs gradually and may involve an array of cellular processes. Secondary injury, which is not caused by mechanical damage, can result from the primary injury or be independent of it. The fact that people sometimes deteriorate after brain injury was originally taken to mean that secondary injury was occurring. It is not well understood how much of a contribution primary and secondary injuries respectively have to the clinical manifestations of TBI. Primary and secondary injuries occur in insults other than TBI as well, such as spinal cord injury and stroke. In TBI, primary injuries result immediately from the initial trauma. Primary injury occurs at the moment of trauma and includes contusion, damage to blood ...
Brain injury can occur in different ways. Trauma is often involved, such as a sports injury, fall or motor vehicle accident. Brain injury can also occur without trauma, for example, the result of a stroke or infection.. Medical care is the first step in treatment to stabilize and promote the brains healing. For long-term treatment planning, rehabilitation plays an important role. With a long track record of experienced, specialized brain injury rehabilitation, HealthSouth has restored hope and encouraged maximum outcomes for many patients and their families.. Brain injury rehabilitation focuses on: ...
Brain injury or damage is the destruction or degeneration of brain cells. Brain injury can be caused by a variety of internal and external factors. A common category is traumatic brain injury that occurs after head damage from an outside source. Mild traumatic brain injury may cause temporary dysfunction of brain cells. More serious traumatic brain injury can result in more extensive physical damage to the brain that can lead to long-term complications or death. Loss of brain function can also be caused by stroke, a temporary loss of blood supply to the brain, which deprives brain tissue of oxygen and food and causes consequent brain cell death.. Feinstein Institute researchers are studying different aspects of brain injury. They are developing "smart catheters," the next generation of monitoring devices that will allow clinicians to continuously measure functional parameters in the injured brain during surgery. They are studying recovery from central nervous system injury, like spinal cord ...
Traumatic brain injury (TBI, physical trauma to the brain) can cause a variety of complications, health effects that are not TBI themselves but that result from it. The risk of complications increases with the severity of the trauma; however even mild traumatic brain injury can result in disabilities that interfere with social interactions, employment, and everyday living. TBI can cause a variety of problems including physical, cognitive, emotional, and behavioral complications. Symptoms that may occur after a concussion - a minor form of traumatic brain injury - are referred to as post-concussion syndrome. Generally, there are six abnormal states of consciousness that can result from a TBI: Stupor is a state of partial or near complete unconsciousness in which the patient is lethargic, immobile, and has a reduced response to stimuli. Coma is a state in which the patient is totally unconscious and cannot be aroused even with strong stimuli. Persistent vegetative state is a condition in which ...
Patients who are hospitalized and who have suffered mild TBI (loss of consciousness or post-traumatic amnesia; Glasgow Coma Score 13-15; admitted within 24 hours of injury; able to read, speak, and understand English) who do not have pre-injury dementia or significant cognitive impairment will undergo computerized neuropsychologic testing using a previously validated tool that has been effective in sports-related mild TBI. Sequential testing will be performed during recovery and patients who report disabling symptoms and/or functional impairment will be compared to patients who recover uneventfully. Goal is to identify those parameters that predict early who may suffer long term sequelae or functional impairment and therefore benefit from early cognitive rehabilitation. Secondary goals are to establish objective parameters for functional recovery after mild TBI ...
New Book - Mild Traumatic Brain Injury: Symptom Validity Assessment and Malingering - Editors: Dominic A. Carone and Shane S. Bush Publication Date: 8/2012448pp SoftcoverISBN-13: 9780826109156. Price: $75.00 USDThis authoritative volume is the first book specifically devoted to symptom validity assessment with individuals having a known or suspected history of mild traumatic brain injury (MTBI). It brings together leading experts in MTBI, symptom ... International Brain Injury Association - IBIA International Brain Injury Association - IBIA
Study evaluates associations between fresh frozen plasma (FFP) and platelet transfusions with long-term functional outcome and survival in patients with traumatic brain injury (TBI) and moderate hemostatic laboratory abnormalities. Data examined included patient demographics, several initial injury severity metrics, daily laboratory values, Glasgow Outcome Score- Extended (GOSE) scores, Functional Status Examination (FSE) scores, and survival to 6 months. Correlations were evaluated between these variables and transfusion of FFP, platelets, packed red blood cells (RBCs), cryoprecipitate, recombinant factor VIIa, and albumin. Analyses showed significant correlations between poor outcome scores and FFP, platelet, or packed RBC transfusion; the volume of FFP or packed RBCs transfused also correlated with poor outcome. Several measures of initial injury and laboratory abnormalities also correlated with poor outcome. Patient age, initial Glasgow Coma Scale score, and highest recorded serum sodium ...
Traumatic brain injury (TBI) is said to be one of the signature injuries of the conflict in Iraq, and accounts for a larger proportion of troop casualties than it has in previous wars fought by the United States. According to the Defense and Veterans Brain Injury Center, the U. S. military formally diagnosed 2,121 cases…
Traumatic brain injury patients frequently undergo tracheal intubation. We aimed to assess current intubation practice in Europe and identify variation in practice. We analysed data from patients with traumatic brain injury included in the prospective cohort study collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI) in 45 centres in 16 European countries. We included patients who were transported to hospital by emergency medical services. We used mixed-effects multinomial regression to quantify the effects on pre-hospital or in-hospital tracheal intubation of the following: patient characteristics; injury characteristics; centre; and trauma system characteristics. A total of 3843 patients were included. Of these, 1322 (34%) had their tracheas intubated; 839 (22%) pre-hospital and 483 (13%) in-hospital. The fit of the model with only patient characteristics predicting intubation was good (Nagelkerke R2 64%). The probability of tracheal intubation ...
Objectives. Voluntarily stopping an on-going motor response has been shown to engage a specific prefrontal-basal-ganglia (PBG) neural network. However, it is not known whether the PBG network is also crucial for other types of response inhibition such as suppressing an urge to act (i.e., habitual impulse), a common impairment after traumatic brain injury (TBI). The objectives of this protocol are: 1) to determine whether the PBG network is engaged in suppressing habitual impulses and, 2) to determine the extent to which the (PBG) neural network can account for the deficiency in response inhibition after mild to moderate traumatic brain injury (TBI). The proposed studies will involve performance of simple behavioral tasks, functional magnetic resonance imaging (fMRI), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and diffusion tensor imaging (DTI). tDCS will be applied separately from fMRI scans. TMS will be applied separately or concurrently during fMRI ...
BACKGROUND: Serum albumin level is correlated with outcome in various clinical situations. Albumin has multiple physiologic properties that could be beneficial in brain injury. The Lund therapy for elevated intracranial pressure uses albumin as part of its protocol and demonstrates favorable outcome. We sought to find out if albumin is associated with outcome after traumatic brain injury to justify conducting a randomized trial. METHODS: A retrospective study of traumatic brain injury patients was conducted. Characteristics known to influence outcome were included in a multiple logistic regression model to analyze predictors of poor outcome at 6 months.. RESULTS: Data were available for 138 patients. The majority of patients (65%) had a severe injury (Glasgow Coma Scale score ,9). Seventy percent of patients had a favorable outcome. Albumin levels decrease considerably from normal values in the first few days after injury irrespective of outcome. Albumin remained ,25 g/L for a longer period of ...
One of the most common deployment injuries is a mild Traumatic Brain Injury (TBI). A mild TBI is an injury to the head that can affect brain functioning. However, traumatic brain injury involves more than getting hit on the head; it also means that the brain temporarily stops working in its usual way. A service member with a traumatic brain injury might become dazed, or see stars, or have trouble remembering what happened before or after the injury, or even become unconscious for a few seconds to half an hour ...
A traumatic brain injury is caused by a bump or blow to the head or an injury that disrupts the normal function of the brain. Often the injury seems harmless at first and the person notices they arent thinking or performing like they used to. Traumatic brain injuries can range from a mild concussion, brief change in mental status or consciousness to a severe extended period of unconsciousness or amnesia. Veterans are at high risk for traumatic brain injury and blast-related concussions. These types of injuries account for more than 65 percent of combat injuries, and of these vets, 60 percent have symptoms of traumatic brain injury.. ...
Prof. Sean Keogh, a retrieval physician, professor of paramedic science at the University of the Sunshine Coast, and CEO at Australian Air Medical in Queensland, suggested that TBI patients should be flown at sea level pressure to avoid an increase in ICP: "Intracranial air is not an absolute contraindication to flying, and there is little evidence that it has ever caused a temporary or permanent neurological decline during air transport, but computer modelling suggests it may increase ICP as cabin pressure decreases. It seems sensible to fly all of these patients in a sea level cabin if possible." Arizona, US-based Angel MedFlight also subscribes to this view, as Kimberly Halloran, vice-president of business development explained: "Altitude can increase ICP, which can be detrimental for patients with brain injuries. To reduce this risk, [we] might fly at a lower altitude than a standard flight, adjust interior cabin pressure, or administer medication to reduce ICP." ...
Original Research: Full open access research for "Subacute Intranasal Administration of Tissue Plasminogen Activator Promotes Neuroplasticity and Improves Functional Recovery following Traumatic Brain Injury in Rats" by Yuling Meng, Michael Chopp, Yanlu Zhang, Zhongwu Liu, Aaron An, Asim Mahmood, and Ye Xiong in PLOS ONE. Published online September 3 2014 doi:10.1371/journal.pone.0106238. [divider]Open Access Neuroscience Abstract[/divider]. Subacute Intranasal Administration of Tissue Plasminogen Activator Promotes Neuroplasticity and Improves Functional Recovery following Traumatic Brain Injury in Rats. Traumatic brain injury (TBI) is a major cause of death and long-term disability worldwide. To date, there are no effective pharmacological treatments for TBI. Recombinant human tissue plasminogen activator (tPA) is the effective drug for the treatment of acute ischemic stroke. In addition to its thrombolytic effect, tPA is also involved in neuroplasticity in the central nervous system. However, ...
TY - JOUR. T1 - Working memory in patients with mild traumatic brain injury. T2 - Functional MR imaging analysis. AU - Chen, Chi-Jen. AU - Wu, Chih-Hsiung. AU - Liao, Yen Peng. AU - Hsu, Hui Ling. AU - Tseng, Ying-Chi. AU - Liu, Ho Ling. AU - Chiu, Wen-Ta. PY - 2012/9. Y1 - 2012/9. N2 - Purpose: To analyze brain activation patterns in response to tests of working memory after a mild traumatic brain injury (MTBI). Materials and Methods: Research ethics committee approval and patient written informed consent were obtained. Brain activation patterns in response to n-back working memory tasks (n = 1, 2, 3) were assessed with functional magnetic resonance (MR) imaging in 20 patients with MTBI within 1 month after their injury and in 18 healthy control subjects. In n-back working memory tasks, participants monitored a series of number stimuli and were to indicate when the presented number was the same as that presented n back previously. Nine (45%) MTBI patients underwent follow-up functional MR ...
Primary objective : During childhood, the central nervous system is in a state of rapid development which can be interrupted by a traumatic brain injury (TBI). This study aimed to describe if and how TBI during childhood influences health and life situation, 5-8 years later.. Research design : A case-control retrospective design was employed for the assessment of 61 adolescents and young adults with a mild, moderate or severe TBI and 229 matched controls from a normative group (16-24 years).. Methods and procedures : SF-36 (Short Form 36 health survey) and a self-reported questionnaire measuring life situation were distributed to youths suffering TBI 5-8 years ago. Forty-five youths (74%) completed the questionnaires.. Main outcomes and results : Participants with a TBI stated lower self-estimated health compared with the normative group.. Remaining self-reported symptoms were physical and cognitive. Negative effects of TBI influencing school results, leisure activities and thoughts about future ...
Abstract Traumatic brain injury (TBI) is the leading cause of morbidity and mortality in children worldwide. This study was conducted to report the presentation, management, outcomes and prognostic indicators in a large series of patients from a tertiary care centre in a developing country. It is a review of prospectively collected data of paediatric patients with TBI admitted at our centre between July 2010 and December 2013. A total of 291 patients with a mean age of 7.2±5.0 years were dichotomised into survivors and non-survivors, and variables were compared between the two groups. The mean post-resuscitation Glasgow coma scale (GCS) score was 11.6±3.9, mean Marshall Score was 2.26±0.95 and the mean revised trauma score at presentation was 10.58±1.7. Younger age, lower GCS score after resuscitation, lower revised trauma score, absent cisterns on imaging, associated subarachnoid haemorrhage (SAH) and intraventricular haemorrhage (IVH) and a lower Marshall score were associated with higher
Principle Investigator: Ruben J. Echemendia, Ph.D.. Institution: Pennsylvania State University, Department of Psychology. Title: Neuropsychological Assessment of Sports-Related Mild Traumatic Brain Injury: A Prospective Multi-Sport Study. Update. Abstract: Mild Traumatic Brain Injuries (mTBI) are serious, at times catastrophic, injuries which pose risks to athletes as all levels of competition. The Penn State Cerebral Concussion Program was developed in 1995 as a multi-sport (both sexes) prospective state-of-the-art neuropsychological assessment program. Recognize as a model for neuropsychological testing programs, baseline assessments have been conducted with 476 athletes in football, ice hockey, mens and womens soccer, mens and womens basketball. Swim teams serve as controls. This proposal requests funds to continue and improve the program. The overall goal of the project is to prevent catastrophic injury by determining when it is safe to return a player to competition. Specific aims ...
This prospective consecutive double-blinded randomized study investigated the effect of prostacyclin on pressure reactivity (PR) in severe traumatic brain injured patients. Other aims were to describe PR over time and its relation to outcome. Blunt head trauma patients, Glasgow coma scale a parts per thousand currency sign8, age 15-70 years were included and randomized to prostacyclin treatment (n = 23) or placebo (n = 25). Outcome was assessed using the extended Glasgow outcome scale (GOSE) at 3 months. PR was calculated as the regression coefficient between the hourly mean values of ICP versus MAP. Pressure active/stable was defined as PR a parts per thousand currency sign0. Mean PR over 96 h (PRtot) was 0.077 +/- A 0.168, in the prostacyclin group 0.030 +/- A 0.153 and in the placebo group 0.120 +/- A 0.173 (p , 0.02). There was a larger portion of pressure-active/stable patients in the prostacyclin group than in the placebo group (p , 0.05). Intra-individual changes over time were common. ...
Kessler Foundation researchers conducted a pilot study to determine ways to assess social communication difficulties in children with impaired social functioning caused by moderate-to-severe traumatic brain injury (TBI). ...
INFLAMMATION DISRUPTS THE BODYS BARRIER SYSTEMS, AND MOST PARTICULARLY, NEURO-NFLAMMATION DISRUPTS THE BLOOD BRAIN BARRIER: There are over 10,000 studies showing that inflammation causes something called LEAKY GUT SYNDROME. But would you have guessed that neuro-inflammation can disrupt the barrier that keeps toxicity out of the brain --- the BBB or Blood Brain Barrier? How big a deal is this? Last Aprils issue of the FASEB Journal (Blood-Brain Barrier Dysfunction and Microvascular Hyperpermeability Following Mild Traumatic Brain Injury) concluded that, "Brain edema, elevated intracranial pressure and reduced cerebral perfusion pressure occurring in traumatic brain injury (TBI) are attributed heavily to the hyperpermeability of the blood-brain barrier (BBB)." This "hyperpermeability of the brain is widely known as "LEAKY BRAIN SYNDROME". Furthermore, just a few months ago on his blog, Ivy League Neurosurgeon and researcher, David Younger, wrote that, "Treatment options have generally been ...
Is the average person at risk for such an injury? Are not traumatic brain injuries something that happens infrequently? Unfortunately, such injuries are not uncommon. Data from the Centers for Disease Control and Prevention reveals that about 1.7 million Americans suffer severe brain injuries every year, and it labels traumatic brain injury a contributing factor in more than 30% of the deaths that result from accidents in the U.S. The CDC reports that more than a quarter of a million people a year need to be hospitalized because of brain injuries. Sadly, about 52,000 people will die from those injures.. Thanks to medical shows on television, most Americans have heard the term "mild concussion." Indeed, brain injuries can be mild, resulting in a brief period of unconsciousness or other temporary change in mental status. But more severe injuries can have devastating consequences, causing changes in an individuals ability to think, to remember, and to use reasoning capabilities. Further, traumatic ...
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The overall aim of the research presented here was to expand the knowledge on metabolic course and nutritional outcome in patients with severe traumatic brain injury and to analyze the use and accuracy of different methods of assessment.. Study I, a systematic review of 30 articles demonstrated consistent data on increased metabolic rate, of catabolism and of upper gastrointestinal intolerance in the majority of the patients during early post injury period. Data also indicated a tendency of less morbidity and mortality in early fed patients.. Study II, a retrospective survey, based on medical records of 64 patients from three regions in Sweden, showed that the majority of patients regained their independence in eating within six months post injury. However, energy intake was set at a low level and 68 % of the patients developed malnutrition with 10 to 29 % loss of initial body mass during the first and second month post injury.. Study III, a questionnaire based study addressed to 74 care units ...
Brain injuries can be very traumatic. If you have experienced one, there are two crucial steps to take. First, you must make sure that you are being treated for your injury by a medical professional. Secondly, it\s very important to consult with a qualified brain injury attorney in order to determine whether or not you have a case against the person who was responsible for your injury.. If you include skull and facial fractures in the statistics, a total of approximately two million head injuries occur every year in the United States. One and a half million of them are nonfatal traumatic brain injuries which do not require hospitalization, while 300,000 brain injuries are severe enough for hospitalization, and 99,000 of those result in a long lasting disability. Every year, 56,000 people die because of a traumatic brain injury, and this figure accounts for 34% of all injury deaths in the United States. Traumatic brain injuries affect males at twice the rate they affect females, with a higher ...
mild traumatic brain injury treatment market- global mild traumatic brain injury treatment market industry size, growth trend, application potential, forecast, competitive analysis
Traumatic Brain Injury, Read about Traumatic Brain Injury symptoms, causes, diagnosis, and treatment. Also read Traumatic Brain Injury articles about how to live with Traumatic Brain Injury, and more.
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A consortium of physicians and scientists in the Houston region is now undertaking a research initiative to improve diagnosis of mild traumatic brain injury (MTBI) and develop innovative treatment strategies.
The annual incidence of traumatic brain injury (TBI) in the United States is over 2.5 million, with approximately 3-5 million people living with chronic sequelae. Compared with moderate-severe TBI, the long-term effects of mild TBI (mTBI) are less understood but important to address, particularly for contact sport athletes and military personnel who have high mTBI exposure. The purpose of this study was to determine the behavioural and neuropathological phenotypes induced by the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) model of mTBI in both wild-type (WT) and APP/PS1 mice up to 8 months post-injury. Male WT and APP/PS1 littermates were randomized to sham or repetitive mild TBI (rmTBI; 2 × 0.5 J impacts 24 h apart) groups at 5.7 months of age. Animals were assessed up to 8 months post-injury for acute neurological deficits using the loss of righting reflex (LRR) and Neurological Severity Score (NSS) tasks, and chronic behavioural changes using the passive avoidance (PA),
Serious brain injury may require surgical intervention to relieve pressure from bleeding in the brain which can be recognized by a CT Scan obtained in the emergency room. If physical pressure is not continuing in the brain such as may be caused by a hemorrhage inside the skull, more conservative treatment will most likely be required. Regardless of whether surgery is necessary or not, many brain injury patients suffer long-term disabilities, ranging from difficulties with communication, memory, sensory processing, motor function and cognition, to behavioral and mental health deficits. What disabilities a patient suffers and how severe the symptoms are depends on a multitude of variables, such as age, the type and severity of TBI suffered, and the general health of the injured person.. The economic cost of a traumatic brain injury can be staggering. For this reason, its imperative that brain injury victims or their families retain experienced, effective representation. At the Locks Law Firm, our ...