Knight P.G.; Cunningham F.J.; Gladwell R.T., 1983: Concentrations of immuno reactive lhrh discrete brain regions of the cockerel effects of castration and testosterone replacement therapy

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Term newborns with congenital heart disease have widespread brain abnormalities before they undergo cardiac surgery. The imaging findings in such newborns are similar to those in premature newborns and may reflect abnormal brain development in utero.

In late-onset Alzheimers disease (AD), multiple brain regions are not affected simultaneously. Comparing the gene expression of the affected regions to identify the differences in the biological processes perturbed can lead to greater insight into AD pathogenesis and early characteristics. We identified differentially expressed (DE) genes from single cell microarray data of four AD affected brain regions: entorhinal cortex (EC), hippocampus (HIP), posterior cingulate cortex (PCC), and middle temporal gyrus (MTG). We organized the DE genes in the four brain regions into region-specific gene coexpression networks. Differential neighborhood analyses in the coexpression networks were performed to identify genes with low topological overlap (TO) of their direct neighbors. The low TO genes were used to characterize the biological differences between two regions. Our analyses show that increased oxidative stress, along with alterations in lipid metabolism in neurons, may be some of the very early ...

I would air dry the slides overnight before heating them at all. Then dry at 60C for 30 min and stain as usual. Somehow the air drying makes a difference. Good luck! jJoyce WeemsPathology ManagerSaint Josephs Hospital of Atlanta404-851-7376404-851-7831 - Fax-----Original Message-----From: [email protected] on behalf of Ryan Dominique SalazarSent: Fri 2/8/2008 3:58 AMTo: [email protected]: [Histonet] brain tissue sections Hi,Please help me with my brain tissue sections, Im having difficulties in staining them because they disintegrate during H&E staining, resulting into folded and incomplete sections into the slide.I processed the tissues 2 days after fixation using Leica ASP300S (all new reagents). I have no problem in cutting 5 u thickness during microtomy.I used adhesive pre-treated slides and Milli-Q water during orientation and fishing out in the floatation bath. I use flattening table as hot plate and heat the freshly cut slides at 62C, for ...

Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate functional and genetic brain architecture. Here we describe the generation and analysis of a transcriptional atlas of the adult human brain, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals. Transcriptional regulation varies enormously by anatomical location, with different regions and their constituent cell types displaying robust molecular signatures that are highly conserved between individuals. Analysis of differential gene expression and gene co-expression relationships demonstrates that brain-wide variation strongly reflects the distributions of major cell classes such as neurons, oligodendrocytes, astrocytes and microglia. Local neighbourhood relationships between fine anatomical subdivisions are associated with discrete neuronal subtypes and genes

The left cerebral hemisphere controls movement of the right side of the body. Depending on the severity, a stroke affecting the left cerebral hemisphere may result in loss of motor skills and sensations on the right side of the body, and may also cause loss of the ability to speak and understand words ...

7 Pillars Of Brain Health What is the secret to maintaining brain health? How a person manages stress, how well they socialize, how well they sleep, how much they exercise, and what they drink and eat all are crucial to brain health. So how does one achieve brain health? Here are seven pillars of […]. ...

Given recent advances in technology, it isnt unusual for a previously paralyzed man or woman regaining the ability to walk thanks to manually-controlled robotic limbs, but now University of California-Irvine researchers have accomplished the feat without such aids.. In a preliminary proof-of-concept study, Dr. An Do, Dr. Zoran Nenadic and colleagues showed that it is possible to use direct brain control to allow a spinal cord injury patient to use his or her own legs to walk again without having to rely upon mechanical aids for locomotion.. The research, which was published in the Journal of NeuroEngineering and Rehabilitation, is said to mark the first time that direct brain control has enabled a person to walk without use of robotic devices following complete paralysis in both legs following a spinal cord injury.. The individual had been a paraplegic for five years, and thanks to an EEG-based brain control system, he was able to walk along a 3.66m long course 30 times over a 19 week span, the ...

Weve been hearing plenty about brain-based learning, but much of what we hear can be confusing. Not only are there arguments about how well brain-based learning works, there are arguments about whether such a thing such as brain-based learning exists at all.. Like so much other recent brain-related news, discussions about brain-based learning have been sparked by the boom in brain science over the past 15 years. With so much new information about the brain filtering into the mainstream, educators have been understandably eager to put to use in the classroom whatever they can.. The rush to use this information in the classroom, however, can be a problem and do more harm to education than good, says Dr. John Bruer, author of The Myth of the First Three Years and president of the James S. McDonnell Foundation, which supports research and education related to the brain. Brain science, says Bruer, can tell us very little about how the brain learns and it is far too early to take what we know at this ...

Natural Size SOMSO Transparent Brain Model BS 25/T is an excellent tool for education. SOMSO Transparent Brain Model BS 25/T may be dissectible in 15 Parts showing anatomical structures. SOMSO Transparent Brain Model BS 25/T is mounted on a green base.

TY - JOUR. T1 - Aluminum Has Both Oxidant and Antioxidant Effects in Mouse Brain Membranes. AU - Oteiza, Patricia I. AU - Fraga, C. G.. AU - Keen, C. L.. PY - 1993/1. Y1 - 1993/1. N2 - The in vitro effects of aluminum (A1) on lipid peroxidation were studied in mouse brain homogenates and purified brain subcellular fractions. In brain homogenates prepared in 5 mM Na2HPO4, 0.14 M NaCl, pH 7.4, the addition of Al decreased Fe2+-induced lipid peroxidation, measured as 2-thiobarbituric acid- reactive substances (TBARS), in a dose dependent manner, with a maximum effect at 250 μM Al. In brain homogenates prepared in 20 mM Tris-HCI, 0.14 M NaCl, pH 7.4, Al acted as a prooxidant at 250 and 500 μM concentrations. The prooxidant effect of Al was enhanced with increasing concentrations of Fe2+. In brain microsonies Al increased TBARS production and conjugated dienes formation, both depending on the addition of Fe2+. In myelin, the prooxidant effect of Al on Fe2+-induced lipid peroxidation was eliminated ...

AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL Academic Article ...

At the intersection of brain health and housing, GBHI is collaborating with Respond Housing Agency to develop a training program that aims to create awareness and understanding of the importance of brain health.

The hippocampus is one of the earliest and most affected regions in Alzheimers disease (AD), followed by the cortex while the cerebellum is largely spared. Importantly, endothelial dysfunction is a common feature of cerebral blood vessels in AD. In this study, we sought to determine if regional heterogeneity of cerebral microvessels might help explain the susceptibility of the hippocampus and cortex as compared to the cerebellum. We isolated microvessels from wild type mice from the cerebellum, cortex, and hippocampus to characterize their vascular phenotype. Superoxide anion was significantly higher in microvessels isolated from the cortex and hippocampus as compared to the cerebellum. Importantly, protein levels of NADPH oxidase (NOX)-2 and NOX-4 were significantly higher in the cortical and hippocampal microvessels as compared to microvessels from the cerebellum. In addition, expression of manganese superoxide dismutase protein was significantly lower in microvessels from the cortex and hippocampus

The method researchers used to assess brain atrophy across 25 published studies, called colocalization-likelihood estimation (CLE), was developed by Peter E. Turkeltaub, MD, PhD, an associate professor of neurology at Georgetown and a co-author of the study.. The researchers found that the frontal region (including anterior cingulate cortex, or ACC) is the most frequently affected brain region in HIV+ adults, whereas the neural injury to the caudate/striatum was consistently linked to neurocognitive impairment.. These results suggest a two-stage model of HAND in the context of brain atrophy, with a frontal/ACC stage that links to HIV disease and likely other comorbidities, such as substance abuse, and a caudate/striatum stage that links to neurocognitive impairment. These two areas likely play different roles in HAND, Jiang says.. It is our theory, and others, that the frontal/ACC area damage is due to a number of factors, but which importantly includes damage to the dopaminergic region, he ...

Just like your habits, the food that you eat can also play a role in your brain health and brain power. There are some foods that can enhance your brain power and brain health. Below are some of them: Fatty Fish Fatty fish must top the list of any discussion regarding the best foods that can boost brain health. Fishes

Our brain plays numerous roles in our daily lives. Basically,our behavior, emotions, memory and other cognitive functions are all linked to our brains health.For these reasons, taking good care of our brains health is very important. So, how can you improve your mental health? Here is a list of ways on how to boost your brains health.

Research by a UConn neurobiologist has demonstrated that a developmental brain disorder that causes a predisposition to seizures can be reversed.. The research, by a team led by Joseph LoTurco, a professor of physiology and neurobiology in the College of Liberal Arts and Sciences, was the cover article in the January issue of the biomedical research journal Nature Medicine.. We showed that adding back a normal gene in a brain that has already developed the wrong way can reverse a previously formed developmental malformation, LoTurco says.. The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perception, thought, and language. Its layered structure is formed during development by the migration of neurons.. The researchers focused on a malformation that happens early in fetal development that is a known risk factor for epilepsy. The malformation is linked to mutations in a certain gene known as Dcx or doublecortin. LoTurco says patients who have a ...

John DSouza mines a rich seam of thinking in this article on Brain-Based Learning... This article has been reproduced in full from its original posting on LinkedIn: Brain-Based Learning 2: BBL - Brain-Based Learning | JOHN DSOUZA | LinkedIn Brain-based learning refers to teaching methods, lesson designs, and school programs that are based on the latest scientific research…

Vitamin D, which supports overall brain structure and function by working with Omega-3 fatty acids to support cognitive function and contains powerful immune support, essential for brain health. CogGevity helps you meet your daily needs for this essential vitamin.. The CogGevity® Scientific Advisory Board members, who are experts in the medical, neuroscience and lifestyle management fields, include: Keith Black, MD, Founder/Chairman and Professor, Department of Neurosurgery, Director, Maxine Dunitz Neurosurgical Institute Ruth and Lawrence Harvey Chair in Neuroscience at Cedars-Sinai Medical Center; Kristen Willeumier, PhD, Neuroscientist-Advisor; Greg Cole, PhD, Developer, Alzheimer Research Lab Professor, UCLA Department of Medicine & Neurology; Sally Frautschy, PhD, Developer/Professor-in-Residence of Neurology, David Geffen School of Medicine at UCLA and Alzheimer Research Lab Professor, Department of Medicine and Neurology; Vernon Williams, MD, Neurologist-Advisor and Director of the ...

BioAssay record AID 299827 submitted by ChEMBL: Drug level in Tg2576 betaAPP swedish transgenic mouse brain at 500 umol/kg, sc twice a day for 5 days.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R01) RFA-MH-08-110. NIMH

Now, writing in the journal Cell Stem Cell (July 1, 2010), a team of scientists from the University of Wisconsin-Madison has identified a single gene that seems to be a master regulator of human brain development, guiding undifferentiated stem cells down tightly defined pathways to becoming all of the many types of cells that make up the brain.. The new finding is important because it reveals the main genetic factor responsible for instructing cells at the earliest stages of embryonic development to become the cells of the brain and spinal cord. Identifying the gene - known as Pax6 - is a first critical step toward routinely forging customized brain cells in the lab.. Whats more, the work contrasts with findings from animal models such as the mouse and zebrafish, pillars of developmental biology, and thus helps cement the importance of the models being developed from human embryonic stem cells.. The new work, conducted in the Waisman Center laboratory of UW-Madison neuroscientist Su-Chun Zhang, ...

TY - JOUR. T1 - The role of nutrition on cognition and brain health in ageing. T2 - A targeted approach. AU - Monti, Jim M.. AU - Moulton, Christopher J.. AU - Cohen, Neal J.. PY - 2015/10/15. Y1 - 2015/10/15. N2 - Animal experiments and cross-sectional or prospective longitudinal research in human subjects suggest a role for nutrition in cognitive ageing. However, data from randomised controlled trials (RCT) that seek causal evidence for the impact of nutrients on cognitive ageing in humans often produce null results. Given that RCT test hypotheses in a rigorous fashion, one conclusion could be that the positive effects of nutrition on the aged brain observed in other study designs are spurious. On the other hand, it may be that the design of many clinical trials conducted thus far has been less than optimal. In the present review, we offer a blueprint for a more targeted approach to the design of RCT in nutrition, cognition and brain health in ageing that focuses on three key areas. First, the ...

By David J. Ostry (Professor, Psychology, McGill) We frequently think of neuroplasticity in the human brain in the context of the developmental and maturational changes that occur in the brain and behaviour during childhood. Luckily, for those of us that are no longer children, the adult human brain remains remarkably plastic. A facet of this plasticity that has important clinical applications is that changes occur in both sensory and motor systems of the brain with surprisingly brief periods of training. I will tell you about a series of recent studies in my laboratory, where we see that the effects of motor learning spill over into sensory systems, and that perceptual learning may provide us with a back door to the motor system that can be exploited in therapeutic interventions. Dr. Ostrys research focuses on understanding the biological mechanisms of voluntary movement and deals equally with speech production and human arm motion. His lab uses mathematical models, robots and behavioral and

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Experiments with rabbits, cats, and monkeys during recording of complex physiological processes (LEPG, ThG, Po2, Pco2, and ECoG) in functionally discrete brain regions of awake animals have shown that functional changes, expressed as desynchronization effects on ECoG, are followed by an increase of local blood flow (LCBF) in regional brain cortex up to 0.3 to 0.4 ml per minute per 1 gm brain tissue or an increase of 35% to 45% of resting levels of LCBF. Under normal physiological conditions LCBF and Po2 change periodically without any external interference at frequency ranges 0.005 to 0.2 cps. This is characteristic of all brain regions and all species of animals investigated. These variations range in amplitude as much as 28% of the mean level of LCBF.. Changes of LCBF have no correlation with changes of systemic blood pressure (SAP). Local control mechanisms appear to be responsible for them. The interrelationships of changes of functional activity and CBF in local regions of awake brain are ...

The BC Brain Wellness Program is an interactive effort to establish clinically relevant lifestyle approaches to complement medical treatment in the clinics at the Djavad Mowafaghian Centre for Brain Health. The goal of the program is to establish a provincial network of wellness programs to support people living with chronic brain disorders and their care partners. ...

The consumption of CBD helps to increase the levels of neurotransmitters in the brain, and it also helps to foster memory and learning.. 5. CBD used as an effective anti-convulsion therapy. CBD is very effective in the treatment or prevention of epilepsy and seizure attacks. The frequent seizures or convulsions are transmitted through the neurological conditions whose frequency can be greatly decreased, with the usage of CBD. The CBD oil and other supplements interact with the endocannabinoid systems and help in reducing the frequency of the convulsion attacks or seizures.. 6. CBD is used as a supplement for better brain health. CBD is a popular supplement which is used worldwide to help deal effectively with depression, migraines, and brain fog. The scientific studies have proved that CBD can be used effectively as a natural alternative to medicines to reduce mental problems, and it also helps to foster better memory, learning, and concentration.. If you want to improve your brain health then ...

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Hello, I have some sample of rat brain which is not perfused with any fixitive before. The tissue is profixed in 4% paraformaldehyde for a week and then processed for paraffin section. But when the section is cut, it expands and breaks when float in water. Does anyone know why this happen and can give suggestion for the protocol? I also have rat brain when received 4% PFA perfucion before dissected out. These whole rat brain is profixed in fixitive overnight and then dehydrated with alcohol, again, after xylene and wex embedding, it breaks up when cut into 8 micron section. Does anyone can give me some suggestions on the protocol? Thanks a lot. Janice Ho University of Hong Kong _______________________________________________ Histonet mailing list [email protected] http://lists.utsouthwestern.edu/mailman/listinfo/histonet ...

Keep in mind, in contrast to most other body organs, your brain cannot fix itself. Exploration considers have indicated that Parkinsons illness, a sensory system malady, is brought about by outside synthetic substances and neurotoxic toxins. As per an article distributed in the Journal of the American Association, ecological synthetic concoctions and neurotoxic toxins are answerable for some instances of Parkinsons sickness.. Food decision is critical to brain health in light of the fact that the food you eat today is not the same as that devoured by your progenitors. What was healthy in yesteryears may not be healthy today. The food you eat today contain not just remote substances in the blood that may harm the brain, yet in addition hormones and brain envoys that may upset brain exercises and consequently harm brain health.. Subsequently, your food decision ought to be founded on accessibility, taste, and cost, be that as it may, in particular, on the nonattendance or nearness of neurotoxic ...

Wait until you hear what our guest, Dr. David Perlmutter, author of the #1 New York Times bestseller Grain Brain, has to say about what foods will and wont positively affect our brain health. You may have heard the controversy resulting from his declaration that wheat, sugar and carbs have devastating effects on brain function ...

J Hepatol. 2011 Oct 22. [Epub ahead of print] Effects of Anti-Viral Therapy and HCV Clearance on Cerebral Metabolism and Cognition. Byrnes V, Miller A, Lowry D, Hill E, Weinstein C, Alsop D, Lenkinsk...

Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimers disease (AD). To determine if higher body mass index (BMI) is associated …

Summary: By optimizing neurons with CRISPR gene editing technology, researchers will have new ways to study genetic influences on brain health and disease, a new study reports.. Source: SfN.. Neuroscientists have used CRISPR/Cas9 genome editing technology to regulate genes in the rat brain. Described in eNeuro, this technique paves the way for researchers to probe genetic influences on brain health and disease in model organisms that more closely resemble human conditions... Studying genes in the brain is expensive and time-consuming, often relying on transgenic animals, such as fruit flies and mice, designed to assess one gene at a time. Despite rapid advances in the development of powerfully precise CRISPR/Cas9 systems, adapting these for use in the central nervous system has proved challenging.. A neuron-optimized CRISPR activation system developed by Jeremy Day and colleagues overcomes these challenges. The researchers demonstrate both in diverse cultured cells and in multiple regions of the ...

The Global Council on Brain Health (GCBH) provides recommendations for how much physical activity is needed to promote brain health as we age.

We provide a protocol for isolation of microglia from different dissected regions of an adult mouse brain hemisphere, followed by...

Brain Health and Cognitive Function expert in Saint Michaels, MD. Learn how to improve your brain health and keep your mental edge as you age.

Brain Health and Cognitive Function expert in Rye, NY. Learn how to improve your brain health and keep your mental edge as you age.

...In studies of human brain cells the widely-used anesthetic desflurane...Over 200 million people undergo surgery each year and there has been ...They subjected human brain cells to 12% desflurane for six hours (mimi...The researchers do emphasize that the current findings are from cell c...,Anesthesia,and,Alzheimers,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters

Our ultimate goal is to be able gather information long term, by checking in with residents each year over a period of decades. In parallel, we will also test the efficacy of evidence-based and other promising interventions to evaluate their effects on promoting brain health. These interventions will be tailored to meet the needs of the Lakewood Ranch community. We will track the immediate and long-term efficacy and sustainability of these interventions on the individual and overall communities. We will also focus on health coaching as a means to sustain these behaviors throughout the lifespan. Thus in summary, our vision is to identify and implement lifestyle interventions at both the individual and community level that can make an immediate and meaningful impact on the lives of the community while simultaneously advancing the science of brain health. ...

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Protecting and nourishing your brain health is a high priority! Brain health starts with whole foods, filtered water, getting restorative sleep and breathing...

Last week, Americas Brain Health Index ranked states by brain health. The top three brain-healthiest places in the US? Maryland, DC and Washington state. I helped judge the Indexs Beautiful Minds contest last year (full disclosure: Im chair of a scientific advisory board of a sponsoring...

Anatomical Brain Stud Earrings Anatomical Brain Stud Earrings Pair of birch brains with burnt-in foldy bits (sulci) Great for neurosurgeons and people whose

We know that high levels of amyloid-beta plaques are characteristic of Alzheimers, but we also know that people can have high levels of amyloid without displaying symptoms of Alzheimers. A new study shows that the reason for this apparent discrepancy may lie with another protein, called NPTX2.. It appears that memory loss occurs when high amyloid-beta occurs in combination with low levels of NPTX2.. The gene which expresses the protein NPTX2 belongs to a set of genes known as immediate early genes, which are activated almost instantly in brain cells when an experience results in a new memory. The protein is used by neurons to strengthen the circuits that encode memories.. A study of 144 archived human brain tissue samples revealed that NPTX2 protein levels were reduced by as much as 90% in brain samples from people with Alzheimers compared with age-matched brain samples without Alzheimers. People with amyloid plaques who had never shown signs of Alzheimers, on the other hand, had normal ...

Immunohistochemical analysis of human brain samples represents an alternative approach for neurogenesis experiments in adult humans [32]. Based on our results, we recommend that the time between death and tissue fixation does not exceed 16 h when devising an immunohistochemistry protocol to study neurogenesis markers in adult humans; thus, the development of a rapid autopsy program [33-35] is desirable. In the indirect immunofluorescence protocol, we noticed that better nestin staining was achieved when the primary antibody solution was maintained on the slides for 48 h at 4°C (Additional file 1: Table S1) [36] instead of overnight at room temperature (data not shown); this finding should be taken into consideration when troubleshooting poor staining of human brain samples.. A caveat of our results is that the staining may not identify a neurogenic system. Indeed, the streptavidin-biotin method revealed biotin staining in negative controls in major bundles such as the fimbria-fornix. To avoid ...