DOI: 10.11607/prd.00.0510 The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. Beta-TCP particles were inserted inside the cylinders and harvested 6 months after placement. The density of the newly formed bone inside the bone-growing chambers measured 27.84% 24.67% in test and 17.90% 4.28% in control subjects, without a statistically significant difference. Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. The present study demonstrates the spontaneous healing of infrabony artificial defects, 2.5 mm diameter, in the jaw. The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation. (Int J Periodontics Restorative Dent 2003;23:69 77 ...

Bioceramics 19: The Effect of Lif-Maleic Acid Added Calcium Aluminate Bone Cement and Ca-PMMA Composite Bone Cement on Bone Regeneration in Rat Calvarial Defects

The aim of this experimental study was to evaluate the effect of bovine lactoferrin (bLF)-loaded gelatin microspheres (GM) used in combination with anorganic bovine bone on bone regeneration in surgically created bone defects around tooth implants. Twenty-four uniform bone defects were created in the frontal bone via an extraoral approach in 12 domestic pigs. Twenty-four implants were placed at the center of the defects. In eight animals one of these defects was filled with 0.3 mL anorganic bovine bone while the other was left empty. In four animals, all defects were filled with 3 mg/defect bLF-loaded GM and anorganic bovine bone. All the defects were covered with collagen membranes. All animals were sacrificed after 10 weeks of healing, and the implants with the surrounding bone defects were removed en bloc. Undecalcified sections were prepared for histomorphometric analysis. The mean total area of hard tissue was 26.9 +/- 6.0% in the empty defect group, 31.8 +/- 8.4% in the graft group, and ...

Objectives: Guided bone regeneration (GBR) is a commonly utilized surgical technique in the craniofacial region. The transcriptional mechanisms associated with this type of bone regeneration are not well understood. The aim of this study was to characterize the transcriptome associated with GBR of a critical-size calvarial defect in the rat. Material and methods: Critical-size calvarial defects were created in six Wistar strain rats and treated according to the principles of GBR. The tissue filling the regenerating defect was harvested at 7 and 14 days. Total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between days 7 and 14. Results: Gene ontology (GO) analysis of the genes up-regulated at day 7 showed that immature wound healing-related mechanisms, such as protein metabolism and cell proliferation, were upregulated at this time point. Furthermore, the immuno-inflammatory process was also up-regulated at the earlier time point. In ...

A common design constraint in functional tissue engineering is that scaffolds intended for use in load-bearing sites possess similar mechanical properties to the replaced tissue. Here, we tested the hypothesis that in vivo loading would enhance bone morphogenetic protein-2 (BMP-2)-mediated bone regeneration in the presence of a load-bearing PLDL scaffold, whose pores and central core were filled with BMP-2-releasing alginate hydrogel. First, we evaluated the effects of in vivo mechanical loading on bone regeneration in the structural scaffolds. Second, we compared scaffold-mediated bone regeneration, independent of mechanical loading, with alginate hydrogel constructs, without the structural scaffold, that have been shown previously to facilitate in vivo mechanical stimulation of bone formation.. Contrary to our hypothesis, mechanical loading had no effect on bone formation, distribution, or biomechanical properties in structural scaffolds. Independent of loading, the structural scaffolds ...

Fingerprint Dive into the research topics of Order versus Disorder: In vivo bone formation within osteoconductive scaffolds. Together they form a unique fingerprint. ...

DOI: 10.11607/prd.1175 This report describes a novel bone reconstructive technique based on guided bone regeneration for extensive three-dimensional hard tissue augmentation. This two-stage technique utilizes bioresorbable osteosynthesis plates, pins, and collagen membranes that form a physical barrier resembling a fence, which contains the bone graft biomaterials composed of a combination of deproteinized bovine bone matrix and autologous bone grafted from intraoral sites. This technique can result in significant bone regeneration with minimal patient discomfort. Four case reports are presented. Histologic analysis of specimens shows the presence of mature bone. This procedure yields favorable results for bone formation, implant placement, and patient satisfaction. (Int J Periodontics Restorative Dent 2013;33:129 136. doi: 10.11607/prd.1175 ...

Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as ...

Bone morphogenetic proteins (BMPs) have been widely investigated for their clinical use in bone repair and it is known that a suitable carrier matrix to deliver them is essential for optimal bone regeneration within a specific defect site. Fused deposited modeling (FDM) allows for the fabrication of medical grade poly ε-caprolactone/tricalcium phosphate (mPCL-TCP) scaffolds with high reproducibility and tailor designed dimensions. Here we loaded FDM fabricated mPCL-TCP/collagen scaffolds with 5 μg recombinant human (rh)BMP-2 and evaluated bone healing within a rat calvarial critical-sized defect. Using a comprehensive approach, this study assessed the newly regenerated bone employing micro-computed tomography (μCT), histology/histomorphometry, and mechanical assessments. By 15 weeks, mPCL-TCP/collagen/rhBMP-2 defects exhibited complete healing of the calvarium whereas the non-BMP-2-loaded scaffolds showed significant less bone ingrowth, as confirmed by μCT. Histomorphometry revealed ...

The aim of this study is to investigate the influence of electro-magnetic stimulation on bone regeneration and the effect on bacterial infection. Electro-magnetic stimulation is a promising technique and a powerful tool for the enhancement of bone regeneration. To optimize the amplitude of the electric field and also the magnetic flux density norm a finite element analysis (FEM) simulation was investigated. In conclusion, we demonstrate that a simulation of an electro-magnetic stimulation in an already applied stimulation chamber with DC current could generate suitable values. Future aims include an additional optimization of the magnetic flux density due to the variation of the current. In order to achieve this, a parameter sweep with different diameters of the area of interest will be performed. ...

The treatment of intrabony defects is a real challenge in molar teeth as it is chronic, slowly progressing disease which needs timely intervention. Periodontal inflammation associated with intrabony defect is not a separate entity as it secondarily affects the pulp causing retrograde pulpitis. However, treatment of these lesions will be complicated due to extensive bone loss. The tooth was endodontically treated followed by periodontal surgery to eliminate the deep periodontal pocket and promote bone fill in osseous defect. PepGen P-15 composited with platelet rich plasma was utilized for enhancing bone formation. The combination of these graft materials provides synergistic effect on bone regeneration.

Guided Tissue Bone Regeneration is used for patients with gum disease that have bone loss and mobility, to restore their smile and secure their teeth. Dr. Ronald H. Watkins performs procedures to promote bone regeneration at our offices in Phoenix, AZ . Call us today to discuss your options for bone regeneration.

Bone tissue engineering and regenerative medicine are promising strategies for treating bone diseases and reconstructing bone defects. For many years research has been dedicated to understanding the biochemical environment that is required to encourage bone regeneration and the desired properties of biocompatible scaffold materials. These studies demonstrate the potential for stem cell based therapies for bone regeneration. However the field of tissue regeneration is faced with the specific challenge to develop novel tissue regeneration approaches to produce tissue that can simultaneously support loading, but is also porous to allow for cell migration and diffusion of nutrients into the regenerated tissue to maintain viability. Dr. McNamaras research group develop mechanobiology based approaches (compression, vibration, fluid flow and hydrostatic bioreactors) for bone tissue regeneration and apply these methods to overcome limitations of biomaterial based in vitro approaches for bone tissue ...

Guided tissue bone regeneration helps the body regenerate bone around the gums after gum disease. Call Drs. Szymanowski, Periodontists in Sacramento, CA.

Principles of Bone Regeneration 2012th Edition by Jona J. Sela , Itai A. Bab Principles of Bone Regeneration PDF is a timely publication that

TY - JOUR. T1 - Incisive canal cysts related to periodontal osseous defects. T2 - case reports.. AU - Mealey, B. L.. AU - Rasch, M. S.. AU - Braun, J. C.. AU - Fowler, C. B.. PY - 1993/6. Y1 - 1993/6. N2 - The incisive canal cyst is the most common non-odontogenic cyst of the oral cavity. While the cyst has frequently been described, the relationship between the lesion and adjacent periodontal osseous defects has rarely been reported. This paper describes the occurrence and treatment of incisive canal cysts in two patients with severe adult periodontitis on maxillary incisor teeth.. AB - The incisive canal cyst is the most common non-odontogenic cyst of the oral cavity. While the cyst has frequently been described, the relationship between the lesion and adjacent periodontal osseous defects has rarely been reported. This paper describes the occurrence and treatment of incisive canal cysts in two patients with severe adult periodontitis on maxillary incisor teeth.. UR - ...

To present knowledge, macrophages are found in all tissues of the human body. They are a cell population with high plasticity which come with a multitude of functions which appear to be adapted to the respective tissue niche and micro-environment in which they reside. Bone harbors multiple macrophage subpopulations, with the osteoclasts as classical representative of a bone resorbing cells and osteomacs as a bone tissue resident macrophage first described by the expression of F4/80. Both subtypes are found throughout all phases in bone healing. In vivo data on bone regeneration have demonstrated their essential role in initiating the healing cascade (inflammatory phase) but also of the later phases of healing (e.g. endochondral and intramembranous bone formation). To participate in such diverse processes macrophages have to be highly plastic in their functionality. Thus, the widely used M1/M2 paradigm to distinguish macrophage subpopulations may not mirror the comprehensive role of the dynamics ...

The growing science of hard-tissue engineering has introduced various principles and solutions to confront the challenge of bone reconstruction. The process of bone augmentation is mandatory for successful placement and integration of root form dental implants in atrophic jaws. Although different techniques have achieved a predictable amount of horizontal bone gain, vertical augmentation has proven to be a consistent challenge, with often less than desirable results.1 This is especially evident in the posterior mandible, where the inferior alveolar nerve further accentuates the limited amount of available bone height.2 Because of this lack of predictability, a large range of reconstructive techniques and materials have been used: onlay bone grafting, guided bone regeneration (GBR), and distraction osteogenesis to list a few. The advantages and disadvantages of each technique impart its applicability to particular circumstances.3,4 The gold standard, autogenous bone graft, has several ...

Springfield MA Periodontist offers guided bone & tissue regeneration to stabilize teeth or prepare the jaw for dental implants. 413-788-9058

With the aging population and the popularity of oral implants, how to promote or accelerate bone regeneration and repair bone defects is increasingly important...

Bone defects occur as a result of trauma, atrophy or resection of intraosseous lesions. Bone regeneration using autologous or biomaterial bone grafts has evolved enormously in recent decades. Several graft materials, including autografts, allografts, xenografts and alloplasts, have been used for bone augmentation. Synthetic bone, on the other hand, does not imply disease risk, lacks the capacity to promote osteogenesis and osseoinduction, but is a great scaffold for bone neoformation. The healing of large bone defects is directly related to the size and time elapsed since the trauma, when more time elapses, greater is the healing and therefore the maturation of bone tissue. Osteogenesis, osseoinduction and osteoconduction are the three keys to osseointegration. Osteogenesis is the process by which new bone is formed from osteoprogenitor cells; osteoinduction is the stimulation and activation of the osteoprogenitor cells of the surrounding lesion tissue, and osteoconduction is the process by ...

BEGO Implant Systems GmbH & Co. KG, Bremen, Germany. The loss of volume of the alveolar ridge that regularly occurs after tooth extractions can compromise the hard and soft tissue situation for implants and thus the aesthetic outcome. The principle of membranesupported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice. The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment in which damaged or lost bone tissue can be regenerated. Commercially available barrier membranes can be clearly differentiated from one another on the basis of several properties. Factors such as source tissue and preparation process have been just as exhaustively studied as the effect of the species from which the collagen was harvested or the networking properties. To what extent these factors are essential for the biodegradation time of a barrier membrane, for example, ...

BEGO Implant Systems GmbH & Co. KG, Bremen, Germany. The loss of volume of the alveolar ridge that regularly occurs after tooth extractions can compromise the hard and soft tissue situation for implants and thus the aesthetic outcome. The principle of membranesupported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice. The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment in which damaged or lost bone tissue can be regenerated. Commercially available barrier membranes can be clearly differentiated from one another on the basis of several properties. Factors such as source tissue and preparation process have been just as exhaustively studied as the effect of the species from which the collagen was harvested or the networking properties. To what extent these factors are essential for the biodegradation time of a barrier membrane, for example, ...

Bone regeneration and graft is used in dentistery, especially for the dental implant treatment when the bone volume is not adequate.

Regeneration is a process of restoring the biological object structure after its damage. There are three types of bone regeneration: physiological, re

TY - GEN. T1 - Peptide amphiphiles for bone regeneration. AU - Mata, Alvaro. AU - Geng, Yanbiao. AU - Henrikson, Karl. AU - Sergeant, Tim. AU - Aparicio, Conrado. AU - Satcher, Robert L.. AU - Stupp, Samuel I.. PY - 2008/12/1. Y1 - 2008/12/1. UR - http://www.scopus.com/inward/record.url?scp=84869029925&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84869029925&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:84869029925. SN - 9781615670802. T3 - 8th World Biomaterials Congress 2008. BT - 8th World Biomaterials Congress 2008. T2 - 8th World Biomaterials Congress 2008, WBC 2008. Y2 - 28 May 2008 through 1 June 2008. ER - ...

Dental Product Shopper | Bone Regeneration Material | Dental Product Shopper delivers practical, unbiased product information. Our peer to peer product reviews help you select the best products for your practice.

The overall aim of this thesis was to establish whether selected Leeds β-structure self- assembling peptides were suitable candidates for use in skeletal tissue engineering. This was addressed by first carrying out simple cytotoxicity studies on selected SAPs using an osteosarcoma cell line in vitro, followed by assessing extent of bone regeneration / repair and safety in vivo in a rabbit calvarial defect model. In vitro investigations revealed that the SAPs (P11-4, P11-8, P111-12, P11-1S, P11-16 and Pl1- 20) tested were cytocompatible, though the positively charged SAP P11-16 performed less well than other SAPs tested in the contact cytoxicity assay, possibly due to the presence of chemical contaminant introduced during the peptide purification process. Cell proliferation was generally superior on the negatively charged peptides compared with the positively charged peptides and cells appeared to thrive at the lower concentrations (30 mg/mL) of negatively charged SAPs compared with their ...

Monitoring Degradation Process of PLGA/Cap Scaffolds Seeded With Mesenchymal Stem Cells in a Critical-Sized Defect in the Rabbit Femur using Raman Spectroscopy Abstract.

In an article in PLoS Medicine Gert Meijer (University Medical Centre...Until recently say the authors the use of bone grafts from a differe...Given all these problems with bone grafts scientists have attempted t...In their article the authors review the available data on bone tissue ...,Are,scientists,making,progress,in,being,able,to,regenerate,bone,tissue?,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters

Professor Maher Almasri, Dean of the College will be presenting at the Dental Tribune Symposium, Istanbul, on 13 April 2019.. Details:. DT Sempozyum. The presentation will be about Our Patients Do Not Require Augmentation Anymore! Dogma vs. Reality.. Successful placement of dental implants revolves around the availability of adequate bone at the time of implantation, and resorption of the alveolar ridge adversely affects treatment success rates. Guided Bone Regeneration has been used to successfully augment implant sites, and the use of autogenous bone was previously considered the gold standard. However, donor site morbidity and other complications have led to exploration of alternative techniques. Concentrated Growth Factors have been increasingly used as graft materials, with or without other bone scaffolds, mainly because they contain the molecular proteins known as Growth Factors, which seem capable of positively influencing hard and soft tissue regeneration. Nevertheless, efforts are ...

An idea struck. What if we could tap into the bodys ability to regenerate bone to help cancer patients? It was a novel concept … or so I thought.. High-grade bone cancers used to be a death sentence. If a person was lucky, he would get a limb amputated and live a few more years. Then chemotherapy came along and suddenly 70 percent of younger patients with these aggressive bone cancers were surviving.. Doctors could now treat the cancer with chemo, remove the tumors, and replace the bone defect with metal implants. However, metal things tend to break and wear out. As people got older, they needed multiple surgical interventions to fix or replace the implants. That meant hospital stays, risk of complications, sometimes infection.. Instead of medical implants, what if we could use the bodys natural ability to regenerate bone?I couldnt wait to tell my mentor.. It is a great idea, he said. But not a new idea.. Turns out a professor in Japan had been exploring this idea for 25 years already. ...

MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue. This type of coated scaffold could offer a dramatic improvement over the current standard for treating bone injuries, which involves transplanting bone from another part of the patients body - a painful process that does not always supply enough bone. Patients with severe bone injuries, such as soldiers wounded in battle; people who suffer from congenital bone defects, such as craniomaxillofacial disorders; and patients in need of bone augmentation prior to insertion of dental implants could benefit from the new tissue scaffold, the researchers say. Its been a truly challenging medical problem, and we have tried to provide one way to address that problem, says Nisarg Shah, a recent Ph.D. ...

Crushed bone injuries are relatively uncommon compared to compound, oblique and transverse fractures, yet they typically occur in accidents where there is...

Cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, researchers at Columbia University Medical Center found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes.

Regenerative repair of craniomaxillofacial bone injuries is challenging due to both the large size and irregular shape of many defects. Mineralized collagen scaffolds have previously been shown to be a promising biomaterial implant to accelerate craniofacial bone regeneration in vivo. Here we describe inclusion of a 3D-printed polymer or ceramic-based mesh into a mineralized collagen scaffold to improve mechanical and biological activity. Mineralized collagen scaffolds were reinforced with 3D-printed Fluffy-PLG (ultraporous polylactide-co-glycolide co-polymer) or Hyperelastic Bone (90wt% calcium phosphate in PLG) meshes. We show degradation byproducts and acidic release from the printed structures have limited negative impact on the viability of mesenchymal stem cells. Further, inclusion of a mesh formed from Hyperelastic Bone generates a reinforced composite with significantly improved mechanical performance (elastic modulus, push-out strength). Composites formed from the mineralized collagen ...

UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Learn about OSSIX Bone grafting material, OSSIX PLUS and OSSIX Volumax resorbable collagen and barrier membranes, and OSSIX Graft cortical and/or cancellous bone material.

The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, 35) is movable for the regeneration with a certain pulling force and speed. According to the invention the membrane (4, 4′, 24, 35) has, on its surface facing the tissue or bone, means (16) for the biological anchoring and adhesion for tissue or bone cells. These means (16) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts (17), as well as indentations (45, 46, 48) and surface peaks (50) of the membrane.

LADDEC is processed cancellous bone of bovine origin with structure and chemical composition similar to that of human bone. It is a safe biocompatible bone graft that provides an excellent osteoconductive scaffold for rapid regeneration of bone and remodeling of the graft into host bone.

Kunkel, Nadja; Wagner, Andrea; Gehwolf, Renate; Heimel, Patrick; Tempfer, Herbert; Korntner, Stefanie; Augat, Peter; Resch, Herbert; Redl, Heinz; Betz, Oliver; Bauer, Hans-Christian; Traweger, Andreas (2017): Comparing the osteogenic potential of bone marrow and tendon-derived stromal cells to repair a critical-sized defect in the rat femur. In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 11, No. 7: pp. 2014-2023 ...

Non-healing skeletal defects are addressed in over 2.2 million surgical cases each year. Bone morphogenetic protein 2 (BMP2), the main growth factor for bone re...

Dr. Kammeyer continues to be on the leading edge of bone and tissue regeneration. Contact us at 623-556-5442 for further queries.

Principal Investigator：YOSHIOKA HIROTAKA, Project Period (FY)：2014-04-01 - 2017-03-31, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Morphological basic dentistry

RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).

The last two decades have seen an explosion of knowledge and new techniques to regenerate periodontal tissues. Up until the 1980s most surgery was

Sigma-Aldrich offers abstracts and full-text articles by [A Tampieri, E Landi, F Valentini, M Sandri, T DAlessandro, V Dediu, M Marcacci].

Solutions Dental Implants offer soft tissue regeneration to encourage your bodys natural ability to regenerate bone and tissue. Call 623-556-5442

Reconstruction of craniofacial skeletal defects from both congenital and acquired etiologies can often present a daunting challenge. Contemporary strategies emp...

Dr Leandro Bolzoni from the University of Waikatos School of Engineering has been awarded a Health Research Council explorer grant worth $150,000.