Abstract 1964: Bone Morphogenetic Protein Antagonist Protein Related to Dan and Cerberus Promotes Differentiation of...
The molecular factors that regulate cardiac differentiation have been extensively studied, yet, relatively little is known about how cardiomyocytes acquire atrial versus ventricular characteristics. Embryonic stem (ES) cells, which have the potential to differentiate to a wide array of distinct cell types, including most types of cardiovascular cells, offer a pertinent in vitro model to work out the molecular mechanisms of atrial specification and differentiation. We discovered that the secreted antagonist of BMP signaling, Protein Related to Dan and Cerberus (PRDC, also called Gremlin2) leads to a surge in cardiomyocytic differentiation when applied to mouse ES-derived cardiac progenitor cells. This property is unique to PRDC among tested BMP antagonists. Lineage expansion is restricted to cardiomyocytes, with the differentiation of endodermal, blood, endothelial and neuronal cells being unaffected. Using molecular and electrophysiological analyses, we show that PRDC-induced cardiomyocytes ...
Gene Expression Literature Detail
J:133691 Choi M, Stottmann RW, Yang YP, Meyers EN, Klingensmith J, The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res. 2007 Feb 2;100(2):220-8 ...
In vitro and In vivo imaging of antivasculogenesis induced by Noggin p by Hye-Won Kang, Ronn P. Walvick et al.
Noggin protein is a potent bone morphogenetic protein (BMP) antagonist capable of inhibiting vasculogenesis even in the presence of provasculogenic VEGF and FGF-2. We found that human umbilical vein endothelial cells (HUVECs) do not express Noggin in culture and used these cells for modeling of antivasculogenesis. We hypothesized that high-efficiency transduction of HUVECs with bicistronic lentiviral vector encoding Noggin and enhanced green fluorescent protein (EGFP) enables direct visualization of Noggin effects in homogenous primary cell populations in vitro and in vivo. By comparing HUVECs transduced with a control GFP and GFP/Noggin expression cassettes, we showed that constitutive and orthotopic Noggin protein expression did not influence cell proliferation, down-regulated BMP-2 expression, and showed no effect on BMP receptor transcripts. We demonstrated that in contrast to GFP-only control, Noggin expression in endothelial cells abrogated endothelial migration in response to monolayer injury,
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Human BMP2 ELISA Kit (ab119581) | Abcam
Human BMP2 ELISA Kit is a sensitive (| 2 pg/ml) immunoassay suitable for the quantification of BMP2 in Cell culture supernatant, Serum, Plasma, Other biological fluids, Tissue Extracts samples.
A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling |...
Several models have been proposed to explain the anti- and pro-Bmp mechanisms of Bmper (Coles et al., 2004). Recently, a paper using biochemical and genetic studies in Drosophila proposes a model where Cv-2 can enhance and inhibit Bmp signaling at low and high concentrations, respectively (Serpe et al., 2008). Dependency on concentration and proteolytic cleavage have also been reported for other extracellular modulators of Bmp activity (Larrain et al., 2001). Our data provide an additional mechanism whereby proteolysis and concentration dependency fine-tune Bmp signaling through interactions with secreted proteins.. Although both proteolytic activation and inactivation have been described for several Bmp factors, the degradation of secreted Bmps are incompletely understood. To date, limited data are available describing Bmp degradation (Entchev et al., 2000; Degnin et al., 2004). Lysosomal- and proteasomal-dependent degradation of Bmp4 within the presecretory pathway was shown to occur after the ...
BMP8B Gene - GeneCards | BMP8B Protein | BMP8B Antibody
Complete information for BMP8B gene (Protein Coding), Bone Morphogenetic Protein 8b, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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Bone morphogenetic protein 3 - Wikipedia
Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene. The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMPs) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMPs in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues. GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic). Human BMP3 genome location and BMP3 gene details page in the UCSC Genome Browser. Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (March 1990). Chromosomal ...
A013 | Bone Morphogenetic Protein 2 (BMP2)- Cloud-Clone Corp.
|p|Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition. BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.|/p||p|Bone morphogenetic protein 2 is shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States.|/p|
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Objective: Pancreas organogenesis is orchestrated by interactions between the epithelium and the mesenchyme, but these interactions are incompletely understood. Here we investigated a role for BMP signalling within the pancreas mesenchyme and found it to be required for the normal development of the mesenchyme as well as the pancreatic epithelium.. Research Design and Methods: We analysed active BMP signalling by immunostaining for phospho-Smad1,5,8 and tested whether pancreas development was affected by BMP inhibition after expression of Noggin and dominant negative BMP receptors in chicken and mouse pancreas.. Results: Endogenous BMP signalling is confined to the mesenchyme in the early pancreas and inhibition of BMP signalling results in severe pancreatic hypoplasia with reduced epithelial branching. Notably, we also observe an excessive endocrine differentiation when mesenchymal BMP signalling is blocked, presumably secondary to defective mesenchyme to epithelium signalling.. Conclusions: We ...
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Worldwide Bone Morphogenetic Protein (BMP) 2 Market Is Growing at a Swift Pace at a CAGR by 2029 - PharmiWeb.com
The Global Bone Morphogenetic Protein (BMP) 2 Market 2020-2029 is exhaustively researched and analyzed in the report to support market players to grow their business tactics and ensure long-term success. The authors of the report have used simple-to-understand language and uncomplicated statistical images but provid...
A truncated bone morphogenetic protein 4 receptor alters the f...
A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of vent
Bone Morphogenetic Proteins and Their Receptors
Bone morphogenetic proteins (BMPs) are importantsignalling molecules that were first identified by their ability to induce
bone and cartilage, and subsequently were shown to be pleiotropic cytokines controlling a wide variety of biological responses
during early development, skeletogenesis and homoeostasis of several tissues
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Decrease in expression of bone morphogenetic proteins 4 and 5...
Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis: Bone morphogenetic pr
Bone morphogenetic protein signalling dynamics in hFOBs | Open-i
Bone morphogenetic protein signalling dynamics in hFOBs under two-dimensional and three-dimensional culture conditions. (a) hFOBs in two-dimensional monolayer c
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Bone Morphogenetic Proteins (BMPs)
Bone Morphogenetic Proteins (BMPs), their structure, action and detailed description of BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7.
ZFIN Publication: Chen et al., 1997
The first evident break in left-right symmetry of the primitive zebrafish heart tube is the shift in pattern of BMP4 expression from radially symmetric to left-predominant. The midline heart tube then jogs to the left and subsequently loops to the right. We examined 279 mutations, affecting more than 200 genes, and found 21 mutations that perturb this process. Some cause BMP4 to remain radially symmetric. Others randomize the asymmetric BMP4 pattern. Retention of BMP4 symmetry is associated with failure to jog: right-predominance of the BMP4 pattern is associated with reversal of the direction of jogging and looping. Raising BMP4 diffusely throughout the heart, via sonic hedgehog injection, or the blocking of its action by injection of a dominant negative BMP4 receptor, prevent directional jogging or looping. The genes crucial to directing cardiac asymmetry include a subset of those needed for patterning the dorsoventral axis and for notochord and ventral spinal cord development. Thus, the ...
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The association between BMP4 gene polymorphism and its serum level with the incidence of LVH in hypertensive patients | Journal...
In the present study, we explored the correlations of the BMP4 gene polymorphisms and the serum BMP4 levels with the development of LVH among Chinese EH patients. We found that the 6007C , T polymorphism of the BMP4 gene and the serum BMP4 level were significantly associated with the risk to develop LVH. Our in vitro study shows that the BMP4 inhibition in cardiomyocyte by si-RNA technique significantly decreased the Ang II induced cardiomyocyte size and protein content per cell, indicating the importance of BMP4 in the cardiomyocyte hypertrophy. Collectively, our data suggest that both the 6007C , T of the BMP4 gene and the serum BMP4 level may be used as potential marker for LVH incidence among the EH patients.. Bone morphogenetic proteins are osteoinductive growth factors that play a key role in cell differentiation, proliferation, migration, development, and apoptosis. BMP4 has been linked to the receptor-activator of nuclear factor-κB ligand (RANKL) mediated calcification in vessel smooth ...
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TGFβ as a gatekeeper of BMP action in the developing growth plate.
Author(s): Wang, Weiguang; Rigueur, Diana; Lyons, Karen M | Abstract: The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How these pathways interact with one another is an area of active investigation. These two signaling pathways have been described to negatively regulate one another through crosstalk involving Smad proteins, the primary intracellular effectors of canonical signaling. More recently, a mechanism for regulation of the BMP pathway through TGFβ and BMP receptor interactions has been described. Here in this review, we demonstrate examples of how TGFβ is a gatekeeper of BMP action in the developing growth plate at both the receptor and transcriptional levels.
Bone Morphogenetic Proteins as Biomarker
Inspite of doing extensive research work, cancer is still the leading cause of deaths. Its associated cost accounts a largest economic burden worldwide...
View source for Template:Bmp - Embryology
Developmental Signals - Bone Morphogenetic Protein,Bmp]],noinclude>[[Category:Template]][[Category:Term Link]][[Category:Molecular]][[Category:BMP]],/noinclude ...
TamPub - Selaus tekijän mukaan Alarmo, Emma-Leena
Background Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily of growth factors. They are known for their roles in regulation of osteogenesis and developmental processes and, in recent years ...
Forschungsdatenbank PMU SQQUID
Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? ...
February | 2015 | camk kinases
In some cases mice injected with cells transfected with industrial non distinct shRNA showed mixed responses, while these cells had been efficiently applied in vitro. Certainly, even further analysis of this RNA sequence exposed some similarity together with the RNA sequences of bone morphogenic protein two and SMAD5, the two of which are involved in TGF B signaling, which may well make clear the source of these spurious effects. Inhibiting stromal TGF B by intraperitoneal administration of P144 greater the survival rates in all groups irrespective of regardless of whether the cells injected had been untreated or pretreated with TGF B. Tumor histology was analyzed soon after sacrificing the mice, revealing that H157 tumor cells pretreated with TGF B formed greater tumors than untreated cells.. Additionally, this growth was abrogated when mice were handled together with the inhibitory peptide P144, whilst the smallest tumors were detected in animals injected with integrin B3 silenced cells. These ...
Bone morphogenetic protein 2B | definition of bone morphogenetic protein 2B by Medical dictionary
Looking for online definition of bone morphogenetic protein 2B in the Medical Dictionary? bone morphogenetic protein 2B explanation free. What is bone morphogenetic protein 2B? Meaning of bone morphogenetic protein 2B medical term. What does bone morphogenetic protein 2B mean?
Bone morphogenetic protein 5 - Wikipedia
Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene. The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMPs BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver. This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This ...
Bone morphogenetic protein 5 - wikidoc
Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[1][2][3] The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMPs BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver. This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric ...
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. - Oxford...
Bone morphogenetic protein 10 (BMP10) is a member of the TGF-β superfamily and plays a critical role in heart development. In the postnatal heart, BMP10 is restricted to the right atrium. The inactive pro-BMP10 (∼60 kDa) is processed into active BMP10 (∼14 kDa) by an unknown protease. Proteolytic cleavage occurs at the RIRR(316)↓ site (human), suggesting the involvement of proprotein convertase(s) (PCs). In vitro digestion of a 12-mer peptide encompassing the predicted cleavage site with furin, PACE4, PC5/6, and PC7, showed that furin cleaves the best, whereas PC7 is inactive on this peptide. Ex vivo studies in COS-1 cells, a cell line lacking PC5/6, revealed efficient processing of pro-BMP10 by endogenous PCs other than PC5/6. The lack of processing of overexpressed pro-BMP10 in the furin- and PACE4-deficient cell line, CHO-FD11, and in furin-deficient LoVo cells, was restored by stable (CHO-FD11/Fur cells) or transient (LoVo cells) expression of furin. Use of cell-permeable and cell surface
anti-BMP7 antibody | Mouse anti-Human Bone Morphogenetic Protein 7 (BMP7) Monoclonal Antibody-NP 001710.1
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JCI - FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
We report the first high-throughput screen of known pharmaceuticals to determine whether any of these agents would increase BMPR2 signaling. Our study design permitted evaluation of strong activators (without exogenous BMP ligand), weaker activators (with exogenous BMP ligand), and potential inhibitors of BMP signaling. The top 3 activators of BMP-mediated signaling and ID1 target gene expression, FK506 (tacrolimus), FK520 (ascomycin), and rapamycin, are potent immunosuppressants that prevent T cell proliferation by interacting with the immunophilin FKBP12 (50). FK506 appears superior to rapamycin in potentiating BMP signaling because it also inhibits the phosphatase calcineurin (51). In addition, FK506 interacts with FKBP12 associated with all 3 BMPR type 1 receptors (ALK1, ALK2, and ALK3), including those preferred by BMPR2 (ALK1 and ALK3), whereas rapamycin only interacts with ALK2. Cyclosporine shares the calcineurin inhibitory properties of FK506 (52), but as it does not bind FKBP12, it is ...
Expression of BMP and Actin Membrane Bound Inhibitor Is Increased during Terminal Differentiation of MSCs
Chondrogenic differentiating mesenchymal stem cells (MSCs) are mimicking embryonal endochondral ossification and become hypertrophic. BMP (bone morphogenetic protein) and Activin Membrane Bound Inhibitor (BAMBI) is a pseudoreceptor that regulates the activity of transforming growth factor-|i|β|/i| (TGF-|i|β|/i|) and BMP signalling during chondrogenesis. Both TGF-|i|β|/i| and BMP signalling are regulators of chondrogenic cell differentiation. Human bone marrow derived MSCs were chondrogenically predifferentiated in aggregate culture for 14 days. Thereafter, one group was subjected to hypertrophy enhancing media conditions while controls were kept in chondrogenic medium until day 28. Histological evaluation, gene expression by PCR, and Western blot analysis were carried out at days 1, 3, 7, 14, 17, 21, and 28. A subset of cultures was treated with the BMP inhibitor Noggin to test for BMP dependent expression of BAMBI. Hypertrophic differentiated pellets showed larger cells with increased
Jan L Christian - Personal Page
Research Interests: Signal Transduction Bone Morphogenetic Proteins Growth and Embryonic Development Mouse Models Xenopus laevis Proprotein Convertases Hematopoiesis Extracellular Matrix Cell-cell signaling molecules such as bone morphogenetic proteins (BMPs) play critical roles in specifying cell fate during vertebrate embryogenesis. Strict regulation of BMP activity is required to prevent birth defects, degenerative diseases and cancer. Our research program has two major foci: 1) Understanding how BMP activity is regulated by cleavage of the precursor protein and by interactions with the extracellular matrix. We use targeted mutagenesis in mice together with cell biological and biochemical approaches in Xenopus embryos to determine how cleavages within the inactive prodomain of the BMP precursor protein regulate the activity of mature BMP homodimers and heterodimers. One current project in the lab involves analysis of mice carrying a point mutation that prevents cleavage of BMP7. This cleavage ...
The transforming growth factor-beta/bone morphogenetic protein signalling pathway in adipogenesis
Rising obesity epidemic makes the better understanding of transcription factor networks regulating adipogenesis very challenging. Adipogenesis begins with the commitment of pluripotent mesenchymal stem cells to the adipocyte lineage, followed by terminal differentiation of preadipocytes to mature ad …
Taking NO for an answer: NO modulation of BMP2 signalling and osteoinduction (English)
Das Bone Morphogenetic Protein 2 (BMP2) gehört zur TGF-beta Superfamilie und findet seinen Fokus in der osteogenen Aktivierung und in der Anwendung bei der Frakturheilung. Es wird angenommen, dass weitere, bisher unbekannte Verbindungen existieren, die die BMP2-Signalübertragung und die osteogene Aktivität verbessern und somit zu einer verbesserten klinischen Wirksamkeit von BMP2 führen. Für den Stickstoffoxid (NO)-Signalweg ist bereits bekannt, dass im endothelialen Kontext eine Verbindung zum BMP2-Signalweg existiert. Ziel dieser Arbeit war es daher, eine Verbindung zwischen dem NO- und BMP2-Signalweg bezüglich der Regulierung des BMP2-abhängigen Signalwegs und der Osteoinduktion aufzuzeigen. Dies erfolgte durch Anwendung von Inhibitoren (LNAME, ODQ und LY83583) und Aktivatoren (L-Arginin, Deta NONOate, SNAP und YC-1) des NO-Signalwegs, in Kombination mit BMP2. Eine mögliche Verbindung zwischen dem BMP2- und NO-Signalweg, über eine Protein Kinase A (PKA) Brücke, wurde durch die ...
Use and efficacy of bone morphogenetic proteins in fracture healing
Although the efficacy of BMPs as stimulators of bone repair has been demonstrated in model systems and clinical studies, the use of BMPs to enhance fracture healing in the clinical setting is still controversial. Issues such as when, where and how much of which BMP is the most effective and profitab …
Patent US4789732 - Bone morphogenetic protein composition - Google Patents
BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals.
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Bone Morphogenetic Protein 4 (BMP4) for Treating Advanced Stage Neuroblastoma
Pediatric neuroblastoma in its advanced stage (st. IV) is usually lethal. 70% of the affected children die. 50% of the children show upon diagnosis metastasis or a genetic amplification of the oncogene N-myc. This group has a poor prognosis and a 5-year survival rate of only 33%. A drawback of the current standard therapy is the poor efficacy accompanied with severe side effects. Therefore a new treatment of neuroblastoma with a different antitumoral mode of action than the traditional cytotoxics is urgently required ...
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2040 Attempts by our lab to regulate ectopic bone formation in vivo have inadvertently revealed a very important biological phenomenon: excessive expression of the BMP antagonist, Noggin, in the presence of BMP4 induces tumor formation. BMP4:Noggin co-expression at specific ratios generated a malignant mesenchyoma, a mixture of osteosarcoma, rhabdomyosarcoma and undifferentiated neoplastic cells, derived from our implanted muscle-derived stem cells (MDSCs). We believe that these cells displayed aberrant differentiation or became stuck in a mixed differentiated state and underwent oncogenesis as a result of conflicting signals attributable to concurrent Noggin and BMP4 expression. To investigate this hypothesis, we cultured populations of BMP4- and Noggin-expressing MDSCs at various ratios. When grown for 7 weeks, mixed populations cultured at ratios of 1:2 and 1:3 (BMP4-:Noggin-expressing MDSCs) formed more colonies on soft agar than did either mixed populations cultured at a ratio of 1:1 or ...
Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-β superfamily predominantly expressed...
Fingerprint Dive into the research topics of Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-β superfamily predominantly expressed in long bones during human embryonic development. Together they form a unique fingerprint. ...
bone morphogenetic protein 6 Protocols and Video...
Video articles in JoVE about bone morphogenetic protein 6 include Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks.
Search Articles | University of Toronto Libraries
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer of bone and cartilage formation, BMP superfamily signalling has become one of the most heavily investigated topics in vertebrate skeletal biology ...
Proto-Oncogene Proteins / antagonists & inhibitors* Archives - Newsemia
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Gene Expression Literature Detail
J:56303 Hollnagel A, Oehlmann V, Heymer J, Ruther U, Nordheim A, Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem. 1999 Jul 9;274(28):19838-45 ...
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5:42 am
Defendants received payments and/or other consideration, directly or indirectly, from Medicare after submitting false claims for payment, including facts that the use of BMP-2 (bone morphogenetic protein) for this surgery was approved and proper, and that [the patient] was informed, and in fact, knowingly consented to the use of BMP-2 on this spinal surgery, which he did not, the complaint states ...
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TA-14 Erosion
Straw bales were installed is a semi-circle around the down-slope side of the area to be excavated. BMPs installed 9/30/96 (V. Hesch, 4/98). BMPs inspected: 9/30/96 (V. Hesch, 4/98 ...