TY - JOUR. T1 - LONG-TERM EFFECTS ON BONE MINERAL DENSITY AFTER FOUR YEARS OF TREATMENT WITH TWO INTENSIVE COMBINATION STRATEGIES, INCLUDING INITIALLY HIGH DOSE PREDNISOLONE, IN EARLY RHEUMATOID ARTHRITIS PATIENTS: THE COBRA-LIGHT TRIAL. AU - Lucassen, M. J.. AU - ter Wee, M. M.. AU - den Uyl, D.. AU - Konijn, N. P.. AU - Nurmohamed, M. T.. AU - van Schaardenburg, D.. AU - Kerstens, P. J.. AU - Bultink, I. E.. AU - Van Tuyl, L. H.. AU - Boers, M.. AU - Lems, W. F.. PY - 2018/6. Y1 - 2018/6. U2 - 10.1136/annrheumdis-2018-eular.2826. DO - 10.1136/annrheumdis-2018-eular.2826. M3 - Meeting Abstract. VL - 77. SP - 290. EP - 291. JO - Annals of the Rheumatic Diseases. JF - Annals of the Rheumatic Diseases. SN - 0003-4967. ER - ...
Kemmler, W., von Stengel, S., Engelke, K., Haberle, L. and Kalender, W.A. (2010) Exercise Effects on Bone Mineral Density, Falls, Coronary Risk Factors, and Health Care Costs in Older Women The Randomized Controlled Senior Fitness and Prevention (SEFIP) Study. Archives of Internal Medicine, 170, 179-185.
As the population is becoming more aged, osteoporosis is becoming more prevalent and the number of fragility fractures that are occurring is increasing. One of the main predictors of developing osteoporosis in later life is a bone mineral density that is greater than 2.5 standard deviations below the young adult sex-matched mean, though studies have only been able to explain 5% of the variance seen in bone mineral densities between individuals. There is now increasing evidence that the development of osteoporosis can begin in utero and that epigenetic processes, such as DNA methylation, may be central to the mechanism by which early development influences bone mineral density and later bone health. Previous work within the group has identified associations of a 300bp differentially methylated region within the CDKN2A locus with bone mineral content, bone area and areal bone mineral density in offspring from the Southampton Womens Survey(SWS) cohort. As methylation of CDKN2A increases, bone ...
Hakim, O, Darling, A, Hart, K, Berry, J and Lanham-New, S (2011) VITAMIN D STATUS AND VOLUMETRIC BONE MINERAL DENSITY (VBMD) AT THE RADIUS AND TIBIA IN PREMENOPAUSAL CAUCASIAN AND ASIAN WOMEN Full text not available from this repository ...
Dual-energy X-ray absorptiometry (DXA) devices from the three main manufacturers provide different bone mineral density (BMD) values, due in part to technical differences in the algorithms for bone mineral content (BMC) and area measurements and in part to the use of different manufacturer-derived reference databases. As a result, significant differences exist between Hologic, Lunar and Norland systems in the reported young normal standard deviation scores or T-scores. In a number of European countries, including Belgium, a T-score below −2.5 is one of the key criteria for reimbursement of osteoporosis treatments. This paper addresses the first attempt to implement a nationwide, uniform expression of BMD in patients, in order to harmonize drug reimbursement. To this end, measures were taken to implement a uniform expression of BMD in Belgian patients, by converting each manufacturers absolute BMD to standardized BMD (sBMD) values and by establishing a single national reference range.
Market Research Future adds new report of "Bone Densitometers Market Research Report- Global Forecast to 2022" it contains Company information, geographical data and Table of Content. Market Highlight:. Bone densitometry is a sort of non-meddlesome development which is used to evaluate bone mass. This development measures the measure of loss of bone mass in a patients body. Bone mass is the greatness of the skeleton, general or specifically regions. Nowadays, bone densitometry is used as a set up standard to gage the bone material thickness. The market for bone densitometer is creating at a generally conventional rate. Creating senior masses which are exposed to bone related sicknesses has fueled the advancement of bone densitometer market.. The global market for bone densitometers is required to stretch around USD 1.2 billion before the finish of the conjecture time frame and is relied upon to develop at a CAGR of ~5.3%.. Get a Sample Report @ ...
Although widely used for its anti-estrogen properties tamoxifen has estrogen like effects on a number of tissues including bone and liver. Previous studies suggest a preservation of lumbar spine density in postmenopausal women but the effect on the hip had not been addressed. To determine whether tamoxifen prevents bone loss in the early postmenopausal period bone mineral density at the lumbar spine and femoral neck was measured using dual energy X-ray absorptiometry at presentation and 6 monthly thereafter for 1 year in a prospective controlled study. Also indices of bone turnover, serum osteocalcin and urinary hydroxyproline excretion, were assessed. Fifteen early postmenopausal women with Stage I or II breast cancer treated with tamoxifen and 21 normal postmenopausal women were studied. Sex hormone binding globulin and antithrombin III levels in serum were also measured as indices of the hepatic estrogenic activity. Tamoxifen (20 mg daily) prevented bone loss at the femoral neck and lumbar spine.
BACKGROUND: We have previously demonstrated that maternal body build and lifestyle factors predict neonatal bone mineral accrual. However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a fathers bone mass and that of his offspring. METHODS: A total of 278 pregnancies (142 male and 136 female neonates) were recruited from the Southampton Womens Survey, a unique, well-established cohort of women, aged 20-34 yr, who had been assessed before and during pregnancy. The neonates and their fathers underwent whole body dual-x-ray absorptiometry (DXA) within 2 wk of birth using a Lunar DPX (General Electric Corp., Madison, WI) and Hologic Discovery instrument (Hologic Inc., Bedford, MA), respectively; correlation and regression methods were used to explore the parental determinants of neonatal bone mass. RESULTS: After adjusting the paternal DXA indices for fathers age and the neonatal for babys gestational age and age at DXA scan, there were
TY - JOUR. T1 - Bone mineral density changes in lactating adolescent mothers during the first postpartum year. AU - Méndez, Rosa Olivia. AU - Gallegos, Ana Cristina. AU - Cabrera, Rosa María. AU - Quihui, Luis. AU - Zozaya, Ramón. AU - Morales, Gloria G.. AU - Valencia, Mauro E.. AU - Méndez, Marcela. PY - 2013/1/1. Y1 - 2013/1/1. U2 - 10.1002/ajhb.22366. DO - 10.1002/ajhb.22366. M3 - Article. SP - 222. EP - 224. JO - American Journal of Human Biology. JF - American Journal of Human Biology. SN - 1042-0533. ER - ...
PTH is the first Food and Drug Administration-approved agent that stimulates bone formation. According to Crandalls review, many small trials showed that daily subcutaneous PTH increases bone mass and 1 large RCT showed that it reduces fracture risk. The substantial risk reduction with 21 months of PTH resembles that seen with 1 to 2 years of alendronate or risedronate in patients who have osteoporosis (1−4). Treatment with PTH involves daily self-injections and is expensive. Thus, use of PTH should be limited to patients at high risk for fractures who have ≥ 1 vertebral fracture. The currently approved single 18- to 24-month course of daily PTH may not optimize use of PTH. Less frequent administration and shorter, longer, or repeated courses should be tested in trials to find ways to restore the architecture of bone and, perhaps, reach the previously elusive goal of "curing" patients with severe osteoporosis. As Crandall points out, the effect of combining antiresorptives and PTH needs ...
The use of antidepressants was also associated with lower bone mineral density (BMD), but this association was dependent on the persons weight and site of bone measurement.. Osteoporosis is a common disorder and an underlying factor in fragility fractures. Especially in women, the menopause increases the risk of osteoporosis. Other risk factors include low levels of physical activity, smoking, low intake of calcium and vitamin D, as well as some medications and diseases. In the elderly, susceptibility to fracture and serious hip fractures can result in long-term hospitalization and decreased state of health.. Previous studies have shown that also depression is associated with lower bone density. This might be due to the effects of depression-induced long-term stress and increased secretion of inflammatory markers. Furthermore, selective serotonin reuptake inhibitors (SSRIs) used to treat depression have been shown to weaken bone health. However, the majority of studies has focused on ...
To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by both a semiquantitative food frequency questionnaire and by four 1-week dietary records. Dual energy X-ray absorptiometry was performed at five sites: total body, L2-L4 region of the lumbar spine, and three regions of the proximal femur. Serum concentrations of osteocalcin (an osteoblast-specific protein reflecting bone turnover) were measured by a radioimmunoassay. Linear regression models, with adjustment for possible confounding factors were used for statistical analyses. A weak positive association was found between dietary calcium intake as calculated from the semiquantitative food frequency questionnaire and total body bone mineral density (BMD) among premenopausal women. No ...
Author(s): Heilmeier, U; Carpenter, DR; Patsch, JM; Harnish, R; Joseph, GB; Burghardt, AJ; Baum, T; Schwartz, AV; Lang, TF; Link, TM | Abstract: © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: While type 2 diabetes (T2D) is associated with higher skeletal fragility, specific risk stratification remains incompletely understood. We found volumetric bone mineral density, geometry, and serum sclerostin differences between low-fracture risk and high-fracture risk T2D women. These features might help identify T2D individuals at high fracture risk in the future. Introduction: Diabetic bone disease, an increasingly recognized complication of type 2 diabetes mellitus (T2D), is associated with high skeletal fragility. Exactly which T2D individuals are at higher risk for fracture, however, remains incompletely understood. Here, we analyzed volumetric bone mineral density (vBMD), geometry, and serum sclerostin levels in two specific T2D subsets with different fracture
In this study, we focused on vBMD, bone microarchitecture and estimated bone strength of young male adult with CO AGHD and compared with age-matched controls. Our results showed that (1) vBMD of both distal tibia and non-dominant radius were significantly decreased in AGHD patients; (2) CO AGHD patients had significantly decreased cortical area and cortical thickness, as well as trabecular thickness and trabecular bone volume fraction of both tibia and distal radius; (3) CO AGHD patients had lower estimated bone strength; (4) after adjusting for age, BMI and serum levels of testosterone and free T4, serum IGF-1 level was a positive predictor for total vBMD, cortical vBMD, cortical area, trabecular vBMD, bone stiffness and failure load. In our series of CO AGHD patients, the average time course since cessation of rhGH replacement was 6.6 ± 3.3 years and all patients sustained testosterone replacement since 18 years old. We thus conclude that young adult male patients with CO AGHD who are no ...
THURSDAY, March 3, 2016 (HealthDay News) -- Children on medications for attention deficit hyperactivity disorder (ADHD) may have lower bone density than their peers, a new U.S. study suggests.. Using data from a government health survey, researchers found that children taking ADHD medications had, on average, lower bone density in the hip and lumbar spine (lower back) than kids not on the drugs.. These prescription medications included stimulants such as Ritalin and Adderall, and nonstimulants, like Strattera.. Experts said its not clear that the medications themselves actually thin kids bones, as the study only showed an association, and there could be other explanations for the connection.. "Im in no way saying that kids shouldnt be on these medications," said Dr. Jessica Rivera, the senior researcher on the study and an orthopedic surgeon with the U.S. Army Institute of Surgical Research, at Fort Sam Houston, Texas.. Studies like this dont give answers -- they raise questions for further ...
Hydrogen peroxide is a common reactive oxygen species involved in the catalytic mechanism though it is toxic to cells due to its oxidative nature. This work investigates the effects of hydrogen peroxide induced oxidative damage on bone mineral density and mechanical properties of bone which is primarily a composite material composed primarily of collagen fibers and biominerals. Sheep leg bones were exposed to hydrogen peroxide for a week. Bone mineral density was measured by using dual energy X-ray absorptiometry. Compressive modulus tests were applied to bone in order to determine mechanical properties. Our study shows that the hydrogen peroxide induced oxidative stress has negative effects on bone mineral density and stiffness. We observed higher control curve slopes than that of hydrogen peroxide curves which account for lesser stiffness values in the exposed tissue ( ...
Osteoporosis is a major cause of morbidity and mortality through its association with age-related fractures. Although most effort in fracture prevention has been directed at retarding the rate of age-related bone loss, and reducing the frequency and severity of trauma among elderly people, evidence is growing that peak bone mass is an important contributor to bone strength during later life. The normal patterns of skeletal growth have been well characterized in cross-sectional and longitudinal studies. It has been confirmed that boys have higher bone mineral content, but not volumetric bone density, than girls. Furthermore, in both genders there is a dissociation between the peak velocities for height gain and bone mineral accrual. Puberty is the period during which volumetric density appears to increase in both axial and appendicular sites. Many factors influence the accumulation of bone mineral during childhood and adolescence, including heredity, gender, diet, physical activity, endocrine status and
Bone Densitometers Market (Technology - Axial Bone Densitometry (Dual Energy X-Ray Absorptiometry and Quantitative Computed Tomography) and Peripheral Bone Densitometry (Single Energy X-Ray Absorptiometry, Peripheral Dual Energy X-Ray Absorptiometry, Radiographic Absorptiometry, Quantitative Ultrasound, and Peripheral Quantitative Computed Tomography); End User - Hospitals, Diagnostic Centers, and Specialty Clinics) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2016 - ...
The purpose of this study is to determine if low bone mineral density (a measurement of how thick and strong bones are) improves in adults with HIV infection who switch their HIV medication tenofovir to another HIV medication raltegravir.. Hypothesis:That Bone Mineral Density (BMD) will improve in osteopenic or osteoporotic patients switching from ART including tenofovir disoproxil fumarate (TDF) and a ritonavir-boosted protease inhibitor (r/PI) to ART including RAL+r/PI. ...
OBJECTIVE : Patients with chronic liver disease (CLD) have an increased prevalence of osteoporosis. The aim of this study was to evaluate prospectively the rate of bone loss and potential predictors of increased bone loss in a cohort of patients with CLD. DESIGN : Bone mineral density (BMD) was measured at baseline and at follow-up by dual-energy X-ray absorptiometry at the lumbar spine and the femoral neck. RESULTS : Forty-three patients (31 female, 12 male) were available for a second measurement of BMD, with a median of 25 months (range 18-41) between the measurements. Mean annual bone loss at the lumbar spine and the femoral neck, respectively, was 0.6 +/- 2.0% and 1.5 +/- 2.4% in females and 0.8 +/- 1.9% and 2.9 +/- 2.0% in males. The BMD Z score decreased significantly over time at the femoral neck (P = 0.005 and P = 0.02 for females and males, respectively). Bone loss was increased significantly at the lumbar spine in patients classified as Child-Pugh B + C compared with those classified ...
Your doctor will tell you when your child should be checked for low bone density. In general, your child should be checked for low bone density if they have low levels of vitamin D, limited mobility or poor muscle tone, had 2 or more broken bones (fractures) before age 10, had 3 or more broken bones before age 19, had a vertebral or spine fracture, rett syndrome or other conditions that increase the risk of low bone density
[101 Pages Report] Check for Discount on United States Peripheral Bone Densitometer Market Report 2017 report by QYResearch Group. In this report, the United States Peripheral Bone Densitometer market...
CONTEXT: Treatment of osteoporotic women with PTH increases biochemical markers of bone turnover, increases axial bone mineral density (BMD), and reduces fracture risk. OBJECTIVE: Our objective was to determine the relationship between levels of baseline turnover before PTH therapy and short-term changes in turnover during PTH therapy and subsequent changes in areal and volumetric BMD. DESIGN AND SETTING: We conducted a randomized, placebo-controlled trial at four academic centers. PATIENTS: Patients included 238 postmenopausal women with low hip or spine BMD. INTERVENTION: Subjects were randomized to sc PTH (1-84), 100 mug/d (119 women), for 1 yr. MAIN OUTCOME MEASURE: Bone turnover markers were measured in fasting blood samples collected before therapy and after 1 and 3 months. Areal and volumetric BMD at the spine and hip were assessed by dual-energy x-ray absorptiometry and quantitative computed tomography (QCT) after 1 yr of therapy. RESULTS: Among women treated with PTH alone, the
The findings could have implications for the prevention of osteoporosis.. Osteoporosis, or porous bone, is a disease in which there is a loss of bone mass and destruction of bone tissue. This process causes weakening of the bones and makes them more likely to break. The bones most often affected are the hips, spine, and wrists.. Osteoporosis affects over 10 million Americans, with women four times more likely to develop osteoporosis than men.. Another 34 million people have low bone mass and therefore have an increased risk for osteoporosis. Estrogen deficiency is one of the main causes of bone loss in women during and after menopause. Women may lose up to 20 percent of their bone mass in the five to seven years following menopause.. "Premenopausal women with depression should be screened for low bone mass," says Dr. Giovanni Cizza, senior author of the study who conducted the research while at the National Institute of Mental Health (NIMH).. "They should do a bone mineral density measurement, ...
Introduction:There is considerable amount of controversy about the long term effects of multiparity and duration of breast-feeding on maternal bone mineral density after menopause. This study was conducted to determine whether multiple pregnancy and prolonged duration of breast-feeding are independent predictors of low bone mass in post-menopausal Kurdish women. Methods: In a retrospective study, we evaluated 991 post-menopausal women with mean age of 58.9 years screened for osteoporosis by dual energy X-ray absorptiometry (DXA). According to the parity (1-2, 3-4, 5-7, |7 children) and total duration of breast-feeding (1-24, 25-60, 61-96, |96 months) they were classified. Bone mineral density (BMD) results for femoral neck and lumbar spine were classified into three groups (normal, osteopenia, and osteoporosis) according to the WHO criteria. Binary logistic regression was used to assess the independent associations of low femur or spine BMD with parity and total duration of breast-feeding. Results: We
Bone Density Test Some women are at greater risk for osteoporosis - the decrease of bone mass and density as a result of the depletion of bone calcium and protein - than others. Your physician can help you determine your risk of developing osteoporosis by taking your personal and family medical history, and by performing a bone density test or bone mass measurement. What is a bone density test? A bone density test, also known as bone mass measurement or bone mineral density test, measures the strength a...
01 February 2012 February 2012 - A new study has found that a drug shown to be highly effective in preventing breast cancer in women who are at high risk for the disease appears to worsen age-related bone loss, although the clinical implications of the findings are unclear.. In June 2011, the results of a Canadian-led clinical trial showed that, for postmenopausal women at increased risk of developing breast cancer, the drug exemestane reduced the risk by 65 %, compared with placebo. The new study found that exemestane worsens age-related bone loss by about three-fold compared to placebo.. The new study involved 351 postmenopausal women, with a median age of 61 years, who were not previously diagnosed with osteoporosis, were not on bone medications and were taking calcium and vitamin D supplements. The research team measured bone mineral density using high-resolution CT scans to assess the density or bone strength. After two years, the researchers found a 7.9 % loss of bone density in the ...
TY - JOUR. T1 - The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. AU - Slemenda, C. W.. AU - Turner, C. H.. AU - Peacock, M.. AU - Christian, J. C.. AU - Sorbel, J.. AU - Hui, S. L.. AU - Johnston, C. C.. PY - 1996/4/12. Y1 - 1996/4/12. N2 - To estimate genetic effects on femoral neck geometry and the distribution of bone mineral within the proximal femur a cross-sectional twin analysis was carried out at a university hospital that compared correlations in these traits in pairs of mono- and dizygotic female twins. Monozygotic (MZ, n = 51 pairs, age 49.1 ± 9.3 years) and dizygotic (DZ, n = 26 pairs, age 45.7 ± 11.3 years) twins were randomly selected from a larger sample of twins previously studied. Measurements of bone mineral density (BMD), femoral neck angles and length, cross-sectional area and moment of interia, the center of mass of the narrowest cross-section of the femoral neck, and BMDs of regions within the femoral neck were made. A summary ...
Osteoporosis is a serious health concern, especially for older people. There could be nutritional deficiencies that your family members have, and that should be addressed with your doctor. Once you determine the cause of low bone density, your doctor may recommend certain supplements, such as Vitamin D, Vitamin K, and/or Calcium. A diet rich in these vitamins could potentially prevent future bone density loss and osteoporosis. Foods such as eggs, oily fish (salmon, sardines, tuna), and fortified dairy products are high in Vitamin D. For Calcium-rich foods, try adding broccoli, kale, low-fat dairy, and oily fish to your diet. Exercise has been proven to increase bone density, particularly strength training (squats, lunges, pushups), and weight lifting. Also, cardio exercises such as running/jogging, fast walking, stair climbing, jumping rope, and jump training are great bone density building sports.. ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Xu, H.; Xiong, D. H.; Xu, F. H.; Zhang, Y. Y.; Lei, S. F.; Deng, H. W. Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: a study on postmenopausal chinese women. Acta Biochimica Et Biophysica Sinica. 2005, JAN. 37(1):61-67. ...
Trabecular bone structure as well as bone mineral density (BMD) have impact on the biomechanical competence of bone. In osteoporosis-related fractures, there have been shown to exist disconnections in the trabecular network as well as low bone mineral density. Imaging of bone parameters is therefore of importance in detecting osteoporosis. One available imaging device is cone-beam computed tomography (CBCT). This device is often used in pre-operative imaging of dental implants, for which the trabecular network also has great importance.. Fourteen or 15 trabecular bone specimens from the radius were imaged for conducting this in vitro project.. The imaging data from one dual-energy X-ray absorptiometry (DXA), two multi-slice computed tomography (MSCT), one high-resolution peripheral quantitative computed tomography (HR-pQCT) and four CBCT devices were segmented using an in-house developed code based on homogeneity thresholding. Seven trabecular microarchitecture parameters, as well as two ...
Proximal femur bone density measurements consistently outperformedlumbar spine measurements for fracture prediction, according to studyresults published in the August issue of the Archives of InternalMedicine.
Vitamins C and E, and magnesium helped postmenopausal women maintain healthy bones, and magnesium built bone in girls, in three new studies. In a bone study, doctors combined antioxidant vitamins and resistance training to measure the effect on bone mineral density (BMD) in postmenopausal women. Thirty-four women, average age 66, were divided into four groups to take either 600 mg of vitamin E plus 1,000 mg of vitamin C per day, the same antioxidants plus exercising three times per week, a placebo with the same amount of exercise or just a placebo. After six months, the placebo-only group had lost significant lumbar spine BMD, while the antioxidant-only and antioxidant plus exercise groups remained stable. Magnesium helps increase BMD, but doctors dont know how. In an effort to find out, researchers in an osteoporosis study thought bone turnover, the natural cycle of bone loss and gain, might provide clues. In osteoporosis, bone turnover gets out of balance, as the body loses bone faster than ...
The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant loss of BMD during the study period but the premenopausal women did not. The annual percent decrease of BMD (delta BMD) in the perimenopausal women (-2.40% in average) was significantly greater than that in either of the premenopausal (-0.01%) or over-all postmenopausal women (-0.85%). The subjects who had been postmenopausal for less than 10 years showed a significant bone loss. delta BMD in the postmenopausal women became less marked as the postmenopausal duration increased. The bone loss was accelerated for about 10 years after menopause. The pattern and magnitude of bone loss of Japanese women seemed to be similar to those of Caucasian women. The regression equation for delta BMD based on
Background This cross-sectional study aimed to look for an association in young children between whole body bone mineral content (BMC) and areal bone mineral density (aBMD) and dairy consumption as...
In large cohort studies changes in bone density and mass are often described statistically as mean values over a period of time1,2. This implies that bone loss occurs homogeneously in the study population over the observation period. Also in intervention studies often only mean changes in bone mass and density are reported3. So, for example, information about the number of non-responders are concealed in many studies4. Our study aims to clarify if there are temporary and individual variations in the rate of bone loss over a period of 4 years in an elderly ...
Department of Primary Health Care, Göteborg University, Sweden. Bone mineral content in the lumbar spine was studied in relation to lactation history and number of live births in 126 pre- and postmenopausal Swedish women. Total number of months of breastfeeding was significantly associated with low bone mineral content, and the strength of the association was greatly enhanced by statistical adjustment for menopausal status and body weight. Women with higher parity also had lower bone mineral content, but this observation could be attributed to more breastfeeding among that group. PMID: 2054717 [PubMed - indexed for MEDLINE] ...
Cystic fibrosis (CF) is a common progressive genetic disorder among children which involves lungs, kidneys, intestine and liver. Apart from the significance of genetic factors, various environmental factors particularly bone mineral density are directly associated with CF. Remarkably, bone disease is appeared as a routine and common trait in long term CF survivors which implies that environmental parameters including calcium and vitamin D intake as well as drug inducement are the most important risk factors causing low bone mineral density. Conspicuously, absolute and notable treatment of cystic fibrosis associated to bone disorder must involve investigating the risk factors including the reduced intake of certain vitamins and minerals due to pancreatic inadequacy, modified hormone production, severe and chronic lung infection with increased ranges of bone function cytokines for a weak bone health situation. In this review, focus is on these considerable factors alongside the genetic factors in cystic
Osteoporosis is a major healthcare problem which is conventionally assessed by dual energy X-ray absorptiometry (DXA). New technologies such as high resolution peripheral quantitative computed tomography (HRpQCT) also predict fracture risk. HRpQCT measures a number of bone characteristics that may inform specific patterns of bone deficits. We used cluster analysis to define different bone phenotypes and their relationships to fracture prevalence and areal bone mineral density (BMD). 177 men and 159 women, in whom fracture history was determined by self-report and vertebral fracture assessment, underwent HRpQCT of the distal radius and femoral neck DXA. Five clusters were derived with two clusters associated with elevated fracture risk. Cluster 1 contained 26 women (50.0% fractured) and 30 men (50.0% fractured) with a lower mean cortical thickness and cortical volumetric BMD, and in men only, a mean total and trabecular area more than the sex-specific cohort mean. Cluster 2 contained 20 women (50.0%
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The participants will be evaluated for a) Mineral metabolism: blood calcium, phosphorus, PTH, 25(OH) vitamin D; b) Bone turnover markers: bone-specific alkaline phosphatase, cross-linked C-telopeptide of type I collagen (CTx), and N-terminal propeptide of type I collagen (PINP); c) Bone Mineral Density using a Dual energy x-ray absorptiometry which is the standard method by which bone mass is measured clinically, we will measure bone mass at the lumbar spine, wrist, hip and total body bone mass at 3, and 18 months ...
Results Activity levels were related to body composition outcomes; for example, lean mass index (lean mass/height2) was positively associated with time spent in moderate activity (r=0.40, p=0.02) and negatively with time spent in sedentary activity (r=−0.50, p=0.002). Per cent time spent in sedentary activity correlated negatively with whole body bone mineral density z-score (r=−0.44, p=0.01) and hip bone mineral content (r=−0.38, p=0.03).. ...
PubMed journal article The frequency of low bone mineral density and its associated risk factors in patients with inflammatory bowel disease were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Adequate levels of calcium intake can maximise the positive effect of physical activity on bone health during the growth period of children. Calcium supplementation has been shown to have a positive effect on bone mineral density in postmenopausal women. Calcium and vitamin D supplementation reduces rates of bone loss and also fracture rates in older male and female adults, and the elderly. In institutionalised elderly women, this combined supplementation reduced hip fracture rates. Fruit and vegetable intake was positively associated with bone density in a study in men and women. The exact components of fruits and vegetables, which may confer a benefit to bone are still to be clarified. Moderate alcohol intake is not thought to be harmful to bone. However, chronic alcohol abuse is detrimental to bone health, with one of the mechanisms being a direct toxic effect on bone forming cells ...
The present study confirmed the hypothethetical association between a high Larsen score and low BMD in the femoral neck in a large sample of patients with RA with low to moderately active disease. Moreover, the well known associates of high age and low BMI were independent variables associated with low BMD at all measurement sites. With increasing age, BMD decreased more in women than in men im both the hip and the spine. The current results were confirmed in a large subgroup of corticosteroid naïve patients. This is interesting as these associations had not been studied previously in a large group of corticosteroid naive patients.7,17. Previous studies7,17 showed an inverse association between joint damage, expressed by the Larsen score, and BMD measured by DXA in patients with a disease duration of more than 10 years in relatively small patient groups. With the present study, we confirmed these findings in a large population that was heterogeneous for disease duration and joint damage. The ...
This study is investigating denosumab on bone mineral density and biochemical markers of bone turnover in postmenopausal type 2 diabetes women with low bone
Studies have shown that elderly patients with osteoportic fractures of the hip have decreased bone mineral density (BMD) in the femoral neck in the first year following the fracture. However, a new prospective study of 21 patients found that between one and six years following the hip fractures there was a dramatic increase in BMD at both the femoral neck and lumbar spine measurement sites.. In many cases, the loss of BMD that occurred in the first year after a fracture was completely recouped, according to the study presented Wednesday in scientific paper 29.. The researchers observe that although the investigation is small, the results of the study suggest that pharmacological intervention with agents such as bisphosphonates to prevent accelerated loss of BMD after a hip fracture may not need to be continued indefinitely, if return to baseline BMD is the objective.. Although some studies have demonstrated a direct relationship between the level of activity and increased BMD, there was a ...
AIM: Non-invasive assessment of bone geometry, biomechanics, and mineral content in postmenopausal women by peripheral quantitative Computed Tomography (pQCT). MATERIAL AND METHODS: Total, trabecular and cortical mineral density (totBMD, cortBMD, trabBMD), and the geometrical (total area, trabecular area, cortical area) and biomechanical properties of bone (strength-strain index, cortical thickness) were assessed in 93 consecutive post-menopausal women (mean age: 63+/-7 yrs; age at menopause: 49+/-6 yrs; years since menopause: 14+/-9 yrs) by pQCT at the ultradistal radius of non-dominant forearm. RESULTS: Compared with 50 healthy women at peak of bone mass, volumetric total, trabecular and cortical bone densities were significantly reduced in postmenopausal subjects (TotBMD: 318+/-106 mg/cm3 vs ctr 442+/-100, -28%, ...
The effects of regular non-weight-bearing (NWB) exercise on bone health are largely unknown. The objective of the study was to determine the effects of participation in NWB sports on bone health in adult male recreational athletes. Male cyclists (NWB; n = 27) and runners (weight-bearing [WB]; n = 16) aged 20 to 59 years were recruited from the community. Whole-body and regional bone mineral content and bone mineral density (BMD), and body composition were assessed using dual x-ray absorptiometry. Bone formation and resorption markers, and hormones were measured in serum. Bone-loading history was estimated from a sports participation history questionnaire. Nutrient intake and current physical activity were estimated from 7-day written logs. The NWB athletes had significantly lower BMD of the whole body and spine than the WB athletes, despite having similar age, weight, body mass index, body composition, hormonal status, current activity level, and nutrient intakes. Sixty-three percent of NWB ...