TY - JOUR. T1 - Lumbar spine bone mineral density in US adults. T2 - Demographic patterns and relationship with femur neck skeletal status. AU - Looker, A. C.. AU - Melton, L. J.. AU - Borrud, L. G.. AU - Shepherd, J. A.. PY - 2012/4/1. Y1 - 2012/4/1. N2 - Summary This analysis examines lumbar spine bone mineral density (BMD) of US adults from NHANES 2005-2008 by age, sex, and race/ethnicity. Prevalence of low spine BMD and agreement between the prevalence of low BMD at the spine and femur neck in older adults are also assessed. Introduction Lumbar spine BMD data from a representative sample of the US population have not been previously available. Methods We used data from the National Health and Nutrition Examination Survey 2005-2008 to examine demographic patterns in lumbar spine BMD among US adults age ≫20 years and the prevalence of low lumbar spine BMD in adults age 50 years. Agreement between the prevalence of low BMD at the femur neck and spine in older adults was also assessed. ...
TY - JOUR. T1 - Aspirin and NSAID use in older women. T2 - Effect on bone mineral density and fracture risk. AU - Bauer, Douglas C.. AU - Orwoll, Eric S.. AU - Fox, Kathleen M.. AU - Vogt, Thomas M.. AU - Lane, Nancy E. AU - Hochberg, Marc C.. AU - Stone, Katie. AU - Nevitt, Michael C.. PY - 1996/1. Y1 - 1996/1. N2 - Prostaglandin inhibition by aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit bone loss and preserve bone mineral density (BMD) in vitro and in animal models. The effect of these agents on BMD and fracture risk in postmenopausal women is unknown. We assessed the risk factors for osteoporosis and the use of aspirin and NSAIDs in 7786 white women over age 65. Axial BMD was measured at the same time, and fractures were prospectively documented over the subsequent 4 years of follow-up. In age-adjusted analyses, daily use of aspirin or NSAIDs was associated with a 2.3-5.8% increase in BMD of the hip and spine. The relationship persisted even after adjustment for ...
To assess the prevalence of and risk factors for low bone mineral density in inflammatory bowel disease (IBD), 152 IBD patients and 73 healthy controls were studied. Sixty seven patients had ulcerative colitis, 78 had Crohns disease (52 of them (66.7%) had ileal disease), and seven had indeterminate colitis. Bone mineral density values (g/cm2) measured by dual energy x ray absorbtiometry at the spine (L2-L4), the femoral neck, Wards triangle, and the trochanter were 1.177, 0.948, 0.850, and 0.838 in the patients and 1.228 (p = 0.034), 1.001 (p = 0.009), 0.889 (NS), and 0.888 (p = 0.012) in the control group, respectively. The type or extent of the disease or previous small bowel resection did not have any significant effect on the bone mineral density values. There was a weak, but statistically significant negative correlation between bone mineral density and the total lifetime corticosteroid dose (in the lumbar spine r = -0.164, p = 0.04, the femoral neck r = -0.185, p = 0.02, Wards triangle ...
This study evaluated the effect of anti-osteoporosis treatment with intravenous zoledronic acid during the perioperative period, on the adjacent vertebral body bone mineral density (BMD) after spinal fusion surgery in postmenopausal women with osteoporosis. All data were collected retrospectively from patients medical records using standardized forms, including: demographics (age, BMI, years since menopause); surgical details of levels included (fusion level and cephalad levels); and BMD values. BMD values (g/cm2) were recorded for the overall lumbar spine, for the levels cephalad to the fused segments, and the femoral neck. The group 0 represents the treated group and group 1 represents the untreated group. The table 1 shows the data about the description of demographic and surgery information of treated group and untreated group. Additionally, the table 2 shows the information about cephalad adjacent vertebral and femoral neck BMD value change. The conclusion shows that perioperative zoledronic acid
Fingerprint Dive into the research topics of Trait anxiety and tamoxifen effects on bone mineral density and sex hormone-binding globulin. Together they form a unique fingerprint. ...
TY - JOUR. T1 - LONG-TERM EFFECTS ON BONE MINERAL DENSITY AFTER FOUR YEARS OF TREATMENT WITH TWO INTENSIVE COMBINATION STRATEGIES, INCLUDING INITIALLY HIGH DOSE PREDNISOLONE, IN EARLY RHEUMATOID ARTHRITIS PATIENTS: THE COBRA-LIGHT TRIAL. AU - Lucassen, M. J.. AU - ter Wee, M. M.. AU - den Uyl, D.. AU - Konijn, N. P.. AU - Nurmohamed, M. T.. AU - van Schaardenburg, D.. AU - Kerstens, P. J.. AU - Bultink, I. E.. AU - Van Tuyl, L. H.. AU - Boers, M.. AU - Lems, W. F.. PY - 2018/6. Y1 - 2018/6. U2 - 10.1136/annrheumdis-2018-eular.2826. DO - 10.1136/annrheumdis-2018-eular.2826. M3 - Meeting Abstract. VL - 77. SP - 290. EP - 291. JO - Annals of the Rheumatic Diseases. JF - Annals of the Rheumatic Diseases. SN - 0003-4967. ER - ...
Kemmler, W., von Stengel, S., Engelke, K., Haberle, L. and Kalender, W.A. (2010) Exercise Effects on Bone Mineral Density, Falls, Coronary Risk Factors, and Health Care Costs in Older Women The Randomized Controlled Senior Fitness and Prevention (SEFIP) Study. Archives of Internal Medicine, 170, 179-185.
2014 American Society for Bone and Mineral Research. The goal of our study was to estimate the prevalence of osteoporosis and low bone mass based on bone mineral density (BMD) at the femoral neck and the lumbar spine in adults 50 years and older in the United States (US). We applied prevalence estimates of osteoporosis or low bone mass at the femoral neck or lumbar spine (adjusted by age, sex, and race/ethnicity to the 2010 Census) for the noninstitutionalized population aged 50 years and older from the National Health and Nutrition Examination Survey 2005-2010 to 2010 US Census population counts to determine the total number of older US residents with osteoporosis and low bone mass. There were more than 99 million adults aged 50 years and older in the US in 2010. Based on an overall 10.3% prevalence of osteoporosis, we estimated that in 2010, 10.2 million older adults had osteoporosis. The overall low bone mass prevalence was 43.9%, from which we estimated that 43.4 million older adults had low ...
As the population is becoming more aged, osteoporosis is becoming more prevalent and the number of fragility fractures that are occurring is increasing. One of the main predictors of developing osteoporosis in later life is a bone mineral density that is greater than 2.5 standard deviations below the young adult sex-matched mean, though studies have only been able to explain 5% of the variance seen in bone mineral densities between individuals. There is now increasing evidence that the development of osteoporosis can begin in utero and that epigenetic processes, such as DNA methylation, may be central to the mechanism by which early development influences bone mineral density and later bone health. Previous work within the group has identified associations of a 300bp differentially methylated region within the CDKN2A locus with bone mineral content, bone area and areal bone mineral density in offspring from the Southampton Womens Survey(SWS) cohort. As methylation of CDKN2A increases, bone ...
Hakim, O, Darling, A, Hart, K, Berry, J and Lanham-New, S (2011) VITAMIN D STATUS AND VOLUMETRIC BONE MINERAL DENSITY (VBMD) AT THE RADIUS AND TIBIA IN PREMENOPAUSAL CAUCASIAN AND ASIAN WOMEN Full text not available from this repository ...
Introduction: We investigated the impact of long-term levothyroxine (LT4) treatment on bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal women with differentiated thyroid cancer (DTC) after thyroidectomy.. Material and methods: Sixty-five premenopausal women who received LT4 therapy at least one year (range, 1.5-9.0 years) after thyroidectomy for DTC and 50 premenopausal women without thyroid diseases were enrolled in this study. We measured the Z-scores of lumbar and hip BMD, serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), intact parathyroid hormone (iPTH), N-terminal propeptide of type 1 N procollagen (P1NP), C terminal telopeptide of type 1 collagen (CTX-1), calcium (Ca), phosphorus (P), vitamin D3, and alkaline phosphatase (ALP) in all participants.. Results: In DTC subjects, serum TSH levels were lower, and serum FT4, P1NP, CTX-1, and ALP levels were higher compared with controls. The prevalence of low BMD was higher in ...
Chronic use of systemic glucocorticoids results in progressive bone loss and pathologic fractures. This study identified the predictive variables for bone loss and used peripheral quantitative computed tomography (pQCT) to measure changes in cortical and trabecular bone in patients receiving systemic glucocorticoid therapy of prednisone 15.4 g. Eighty-four asthmatic patients were included in the study. Vertebral fractures were diagnosed via plain spinal radiograms. pQCT was used to measure cortical and trabecular bone mineral density. Multiple regression analysis identified variables with predictive value. The cumulative dose of glucocorticoid correlated with the bone mineral density (p,0.05) and the trabecular bone density (p,0.01). Among patients , or = 65 yrs of age, the cumulative dose of glucocorticoid correlated with the occurrence of vertebral fractures (p,0.05), total bone mineral density (p,0.01) and cortical bone mineral density (p,0.01). Bone mineral density in the distal radius ...
Dual-energy X-ray absorptiometry (DXA) devices from the three main manufacturers provide different bone mineral density (BMD) values, due in part to technical differences in the algorithms for bone mineral content (BMC) and area measurements and in part to the use of different manufacturer-derived reference databases. As a result, significant differences exist between Hologic, Lunar and Norland systems in the reported young normal standard deviation scores or T-scores. In a number of European countries, including Belgium, a T-score below −2.5 is one of the key criteria for reimbursement of osteoporosis treatments. This paper addresses the first attempt to implement a nationwide, uniform expression of BMD in patients, in order to harmonize drug reimbursement. To this end, measures were taken to implement a uniform expression of BMD in Belgian patients, by converting each manufacturers absolute BMD to standardized BMD (sBMD) values and by establishing a single national reference range.
Market Research Future adds new report of Bone Densitometers Market Research Report- Global Forecast to 2022 it contains Company information, geographical data and Table of Content. Market Highlight:. Bone densitometry is a sort of non-meddlesome development which is used to evaluate bone mass. This development measures the measure of loss of bone mass in a patients body. Bone mass is the greatness of the skeleton, general or specifically regions. Nowadays, bone densitometry is used as a set up standard to gage the bone material thickness. The market for bone densitometer is creating at a generally conventional rate. Creating senior masses which are exposed to bone related sicknesses has fueled the advancement of bone densitometer market.. The global market for bone densitometers is required to stretch around USD 1.2 billion before the finish of the conjecture time frame and is relied upon to develop at a CAGR of ~5.3%.. Get a Sample Report @ ...
Although widely used for its anti-estrogen properties tamoxifen has estrogen like effects on a number of tissues including bone and liver. Previous studies suggest a preservation of lumbar spine density in postmenopausal women but the effect on the hip had not been addressed. To determine whether tamoxifen prevents bone loss in the early postmenopausal period bone mineral density at the lumbar spine and femoral neck was measured using dual energy X-ray absorptiometry at presentation and 6 monthly thereafter for 1 year in a prospective controlled study. Also indices of bone turnover, serum osteocalcin and urinary hydroxyproline excretion, were assessed. Fifteen early postmenopausal women with Stage I or II breast cancer treated with tamoxifen and 21 normal postmenopausal women were studied. Sex hormone binding globulin and antithrombin III levels in serum were also measured as indices of the hepatic estrogenic activity. Tamoxifen (20 mg daily) prevented bone loss at the femoral neck and lumbar spine.
Limb bone lengths and bone mineral density (BMD) have been used to assess the bone growth and the risk of bone fractures in pigs, respectively. It has been suggested that limb bone lengths and BMD are under genetic control. However, the knowledge about the genetic basis of the limb bone lengths and mineralisatinon is limited in pigs. The aim of this study was to identify quantitative trait loci (QTL) affecting limb bone lengths and BMD of the distal femur in a White Duroc × Erhualian resource population. Limb bone lengths and femoral bone mineral density (fBMD) were measured in a total of 1021 and 116 F2 animals, respectively. There were strong positive correlations among the lengths of limb bones and medium positive correlations between the lengths of limb bones and fBMD. A whole-genome scan involving 183 microsatellite markers across the pig genome revealed 35 QTL for the limb bone lengths and 2 for femoral BMD. The most significant QTL for the lengths of five limb bones were mapped on two
BACKGROUND: We have previously demonstrated that maternal body build and lifestyle factors predict neonatal bone mineral accrual. However, the paternal determinants of neonatal bone mass are not known. In this study we explored the relationship between a fathers bone mass and that of his offspring. METHODS: A total of 278 pregnancies (142 male and 136 female neonates) were recruited from the Southampton Womens Survey, a unique, well-established cohort of women, aged 20-34 yr, who had been assessed before and during pregnancy. The neonates and their fathers underwent whole body dual-x-ray absorptiometry (DXA) within 2 wk of birth using a Lunar DPX (General Electric Corp., Madison, WI) and Hologic Discovery instrument (Hologic Inc., Bedford, MA), respectively; correlation and regression methods were used to explore the parental determinants of neonatal bone mass. RESULTS: After adjusting the paternal DXA indices for fathers age and the neonatal for babys gestational age and age at DXA scan, there were
TY - JOUR. T1 - Bone mineral density changes in lactating adolescent mothers during the first postpartum year. AU - Méndez, Rosa Olivia. AU - Gallegos, Ana Cristina. AU - Cabrera, Rosa María. AU - Quihui, Luis. AU - Zozaya, Ramón. AU - Morales, Gloria G.. AU - Valencia, Mauro E.. AU - Méndez, Marcela. PY - 2013/1/1. Y1 - 2013/1/1. U2 - 10.1002/ajhb.22366. DO - 10.1002/ajhb.22366. M3 - Article. SP - 222. EP - 224. JO - American Journal of Human Biology. JF - American Journal of Human Biology. SN - 1042-0533. ER - ...
TY - JOUR. T1 - Estimating lumbar bone mineral density from routine radiographs of the lumbar spine. AU - Michel, B. A.. AU - Bjorkengren, A. G.. AU - Lambert, E.. AU - Lane, Nancy E. AU - Fries, J. F.. AU - Bloch, D. A.. PY - 1993/3. Y1 - 1993/3. N2 - To evaluate the information content of lateral lumbar films with respect to bone mineral content, we compared reading criteria with values obtained by quantitative computed tomography (CT) of L1 at baseline and after 5 years. The highest correlations with mineral content were found for the criteria overall assessment of the vertebra, vertebral body density versus soft tissue, and amount of trabeculations. These three reading criteria yielded higher correlations with CT scores in subjects with lower body mass index. Changes in mineral content over the 5-year period could not be read adequately, the average difference representing only a loss of about 10% in the study subjects. We conclude that a rough estimate of bone density can be obtained ...
Researchers assessed the effect of hyperuricemia with and without psoriasis on bone microstructure and volumetric bone mineral density.
TY - GEN. T1 - The effects of exercise on Bone Mineral Density in Men. T2 - a protocol for a systematic review and meta-analysis of randomised controlled trials. AU - Hamilton, Blair Ross. AU - Staines, Katherine. AU - Kelley, George. AU - Kelley, Kristi. AU - Kohrt, Wendy. AU - Pitsiladis, Yannis. AU - Guppy, Fergus Michael. PY - 2020/5/19. Y1 - 2020/5/19. KW - Bone. KW - Exercise. KW - Men. KW - Meta-analysis. KW - Osteoporosis. U2 - 10.31236/osf.io/y8nue. DO - 10.31236/osf.io/y8nue. M3 - Other contribution. PB - SportRχiv ER - ...
PTH is the first Food and Drug Administration-approved agent that stimulates bone formation. According to Crandalls review, many small trials showed that daily subcutaneous PTH increases bone mass and 1 large RCT showed that it reduces fracture risk. The substantial risk reduction with 21 months of PTH resembles that seen with 1 to 2 years of alendronate or risedronate in patients who have osteoporosis (1−4). Treatment with PTH involves daily self-injections and is expensive. Thus, use of PTH should be limited to patients at high risk for fractures who have ≥ 1 vertebral fracture. The currently approved single 18- to 24-month course of daily PTH may not optimize use of PTH. Less frequent administration and shorter, longer, or repeated courses should be tested in trials to find ways to restore the architecture of bone and, perhaps, reach the previously elusive goal of curing patients with severe osteoporosis. As Crandall points out, the effect of combining antiresorptives and PTH needs ...
The use of antidepressants was also associated with lower bone mineral density (BMD), but this association was dependent on the persons weight and site of bone measurement.. Osteoporosis is a common disorder and an underlying factor in fragility fractures. Especially in women, the menopause increases the risk of osteoporosis. Other risk factors include low levels of physical activity, smoking, low intake of calcium and vitamin D, as well as some medications and diseases. In the elderly, susceptibility to fracture and serious hip fractures can result in long-term hospitalization and decreased state of health.. Previous studies have shown that also depression is associated with lower bone density. This might be due to the effects of depression-induced long-term stress and increased secretion of inflammatory markers. Furthermore, selective serotonin reuptake inhibitors (SSRIs) used to treat depression have been shown to weaken bone health. However, the majority of studies has focused on ...
To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by both a semiquantitative food frequency questionnaire and by four 1-week dietary records. Dual energy X-ray absorptiometry was performed at five sites: total body, L2-L4 region of the lumbar spine, and three regions of the proximal femur. Serum concentrations of osteocalcin (an osteoblast-specific protein reflecting bone turnover) were measured by a radioimmunoassay. Linear regression models, with adjustment for possible confounding factors were used for statistical analyses. A weak positive association was found between dietary calcium intake as calculated from the semiquantitative food frequency questionnaire and total body bone mineral density (BMD) among premenopausal women. No ...
Age- and disease (osteoporotic fractured and osteoarthritic tissue)-related changes in the distribution of cortical bone were examined, using a multimodality approach, including measurement of local density, geometry and mechanical properties, where changes in these properties can give rise to instability and increasing probability of fracture. In contrast to the majority of previously reported research, this study also focuses on the characteristic non-circular femoral neck cross-sectional geometry and variation in bone mineral density (BMD) around the femoral neck. Twenty-two osteoarthritic and 7 osteoporotic femoral neck slices, collected from elective and trauma-related arthroplasty, and 16 cadaveric donor tissue controls were tested mechanically using Reference Point Indentation (BioDent™, Active Life Technologies®, Santa Barbara, CA) and then scanned with in vitro-based radiography intended to replicate the dual-energy X-ray absorptiometry technique. All parameters were measured regionally
Author(s): Heilmeier, U; Carpenter, DR; Patsch, JM; Harnish, R; Joseph, GB; Burghardt, AJ; Baum, T; Schwartz, AV; Lang, TF; Link, TM | Abstract: © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: While type 2 diabetes (T2D) is associated with higher skeletal fragility, specific risk stratification remains incompletely understood. We found volumetric bone mineral density, geometry, and serum sclerostin differences between low-fracture risk and high-fracture risk T2D women. These features might help identify T2D individuals at high fracture risk in the future. Introduction: Diabetic bone disease, an increasingly recognized complication of type 2 diabetes mellitus (T2D), is associated with high skeletal fragility. Exactly which T2D individuals are at higher risk for fracture, however, remains incompletely understood. Here, we analyzed volumetric bone mineral density (vBMD), geometry, and serum sclerostin levels in two specific T2D subsets with different fracture
In this study, we focused on vBMD, bone microarchitecture and estimated bone strength of young male adult with CO AGHD and compared with age-matched controls. Our results showed that (1) vBMD of both distal tibia and non-dominant radius were significantly decreased in AGHD patients; (2) CO AGHD patients had significantly decreased cortical area and cortical thickness, as well as trabecular thickness and trabecular bone volume fraction of both tibia and distal radius; (3) CO AGHD patients had lower estimated bone strength; (4) after adjusting for age, BMI and serum levels of testosterone and free T4, serum IGF-1 level was a positive predictor for total vBMD, cortical vBMD, cortical area, trabecular vBMD, bone stiffness and failure load. In our series of CO AGHD patients, the average time course since cessation of rhGH replacement was 6.6 ± 3.3 years and all patients sustained testosterone replacement since 18 years old. We thus conclude that young adult male patients with CO AGHD who are no ...
THURSDAY, March 3, 2016 (HealthDay News) -- Children on medications for attention deficit hyperactivity disorder (ADHD) may have lower bone density than their peers, a new U.S. study suggests.. Using data from a government health survey, researchers found that children taking ADHD medications had, on average, lower bone density in the hip and lumbar spine (lower back) than kids not on the drugs.. These prescription medications included stimulants such as Ritalin and Adderall, and nonstimulants, like Strattera.. Experts said its not clear that the medications themselves actually thin kids bones, as the study only showed an association, and there could be other explanations for the connection.. Im in no way saying that kids shouldnt be on these medications, said Dr. Jessica Rivera, the senior researcher on the study and an orthopedic surgeon with the U.S. Army Institute of Surgical Research, at Fort Sam Houston, Texas.. Studies like this dont give answers -- they raise questions for further ...
Hydrogen peroxide is a common reactive oxygen species involved in the catalytic mechanism though it is toxic to cells due to its oxidative nature. This work investigates the effects of hydrogen peroxide induced oxidative damage on bone mineral density and mechanical properties of bone which is primarily a composite material composed primarily of collagen fibers and biominerals. Sheep leg bones were exposed to hydrogen peroxide for a week. Bone mineral density was measured by using dual energy X-ray absorptiometry. Compressive modulus tests were applied to bone in order to determine mechanical properties. Our study shows that the hydrogen peroxide induced oxidative stress has negative effects on bone mineral density and stiffness. We observed higher control curve slopes than that of hydrogen peroxide curves which account for lesser stiffness values in the exposed tissue ( ...
Osteoporosis, a disease characterized by low bone mineral density (BMD), increases the risk for fractures. Conventional risk factors alone do not completely explain measured BMD or osteoporotic fracture risk. Metabolomics may provide additional information. We aim to identify BMD-associated metabolomic markers that are predictive of fracture risk. We assessed 209 plasma metabolites by LC-MS/MS in 1,552 Framingham Offspring Study participants, and measured femoral neck (FN) and lumbar spine (LS) BMD 2-10 years later using dual energy x-ray absorptiometry. We assessed osteoporotic fractures up to 27-year follow-up after metabolomic profiling. We identified twenty-seven metabolites associated with FN-BMD or LS-BMD by LASSO regression with internal validation. Incorporating selected metabolites significantly improved the prediction and the classification of osteoporotic fracture risk beyond conventional risk factors (AUC=0.74 for the model with identified metabolites and risk factors vs AUC=0.70 ...
TY - JOUR. T1 - Utility of biochemical markers of bone turnover and bone mineral density in management of osteoporosis. AU - Vasikaran, Samuel. PY - 2008. Y1 - 2008. N2 - Biochemical markers of bone turnover (bone-turnover markers) are released during bone formation or resorption and can be measured in blood and/or urine. The concentration of bone-turnover markers in serum or urine reflect bone remodeling activity and can potentially be used as surrogate markers of the rate of bone formation or bone resorption. While the diagnosis of osteoporosis is based on bone mineral density (BMD), the absolute fracture risk for a particular BMD measurement varies several fold depending on age and is also influenced by other clinical risk factors. The measurement of bone-turnover markers may be of additional value to BMD and clinical risk factors in fracture risk assessment by improving the sensitivity and specificity of prediction of future fractures. In clinical practice, bone-turnover markers may help ...
Humans are unique, compared with our closest living relatives (chimpanzees) and early fossil hominins, in having an enlarged body size and lower limb joint surfaces in combination with a relatively gracile skeleton (i.e., lower bone mass for our body size). Some analyses have observed that in at least a few anatomical regions modern humans today appear to have relatively low trabecular density, but little is known about how that density varies throughout the human skeleton and across species or how and when the present trabecular patterns emerged over the course of human evolution. Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the upper and lower limbs compared with other primate taxa and (ii) the reduction in trabecular density first occurred in early Homo erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in concert with diaphyseal gracilization in Holocene humans. We used peripheral quantitative CT and
Osteoporosis is a major cause of morbidity and mortality through its association with age-related fractures. Although most effort in fracture prevention has been directed at retarding the rate of age-related bone loss, and reducing the frequency and severity of trauma among elderly people, evidence is growing that peak bone mass is an important contributor to bone strength during later life. The normal patterns of skeletal growth have been well characterized in cross-sectional and longitudinal studies. It has been confirmed that boys have higher bone mineral content, but not volumetric bone density, than girls. Furthermore, in both genders there is a dissociation between the peak velocities for height gain and bone mineral accrual. Puberty is the period during which volumetric density appears to increase in both axial and appendicular sites. Many factors influence the accumulation of bone mineral during childhood and adolescence, including heredity, gender, diet, physical activity, endocrine status and
Bone Densitometers Market (Technology - Axial Bone Densitometry (Dual Energy X-Ray Absorptiometry and Quantitative Computed Tomography) and Peripheral Bone Densitometry (Single Energy X-Ray Absorptiometry, Peripheral Dual Energy X-Ray Absorptiometry, Radiographic Absorptiometry, Quantitative Ultrasound, and Peripheral Quantitative Computed Tomography); End User - Hospitals, Diagnostic Centers, and Specialty Clinics) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2016 - ...
The purpose of this study is to determine if low bone mineral density (a measurement of how thick and strong bones are) improves in adults with HIV infection who switch their HIV medication tenofovir to another HIV medication raltegravir.. Hypothesis:That Bone Mineral Density (BMD) will improve in osteopenic or osteoporotic patients switching from ART including tenofovir disoproxil fumarate (TDF) and a ritonavir-boosted protease inhibitor (r/PI) to ART including RAL+r/PI. ...
OBJECTIVE : Patients with chronic liver disease (CLD) have an increased prevalence of osteoporosis. The aim of this study was to evaluate prospectively the rate of bone loss and potential predictors of increased bone loss in a cohort of patients with CLD. DESIGN : Bone mineral density (BMD) was measured at baseline and at follow-up by dual-energy X-ray absorptiometry at the lumbar spine and the femoral neck. RESULTS : Forty-three patients (31 female, 12 male) were available for a second measurement of BMD, with a median of 25 months (range 18-41) between the measurements. Mean annual bone loss at the lumbar spine and the femoral neck, respectively, was 0.6 +/- 2.0% and 1.5 +/- 2.4% in females and 0.8 +/- 1.9% and 2.9 +/- 2.0% in males. The BMD Z score decreased significantly over time at the femoral neck (P = 0.005 and P = 0.02 for females and males, respectively). Bone loss was increased significantly at the lumbar spine in patients classified as Child-Pugh B + C compared with those classified ...
Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders. We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin. High-resolution peripheral quantitative computed tomography (HR-pQCT) was additionally performed in a subgroup of 67 patients with T-Score below − 1.5 or history of vertebral fracture. Among 144 patients, 126 patients (87.5%) were older than 60 years. Mean age was 70.1 years. 42 patients (29.1%) had suffered from a vertebral compression fracture. 12 previously undiagnosed vertebral deformities were detected in 12 patients by vertebral fracture
Your doctor will tell you when your child should be checked for low bone density. In general, your child should be checked for low bone density if they have low levels of vitamin D, limited mobility or poor muscle tone, had 2 or more broken bones (fractures) before age 10, had 3 or more broken bones before age 19, had a vertebral or spine fracture, rett syndrome or other conditions that increase the risk of low bone density
[101 Pages Report] Check for Discount on United States Peripheral Bone Densitometer Market Report 2017 report by QYResearch Group. In this report, the United States Peripheral Bone Densitometer market...
CONTEXT: Treatment of osteoporotic women with PTH increases biochemical markers of bone turnover, increases axial bone mineral density (BMD), and reduces fracture risk. OBJECTIVE: Our objective was to determine the relationship between levels of baseline turnover before PTH therapy and short-term changes in turnover during PTH therapy and subsequent changes in areal and volumetric BMD. DESIGN AND SETTING: We conducted a randomized, placebo-controlled trial at four academic centers. PATIENTS: Patients included 238 postmenopausal women with low hip or spine BMD. INTERVENTION: Subjects were randomized to sc PTH (1-84), 100 mug/d (119 women), for 1 yr. MAIN OUTCOME MEASURE: Bone turnover markers were measured in fasting blood samples collected before therapy and after 1 and 3 months. Areal and volumetric BMD at the spine and hip were assessed by dual-energy x-ray absorptiometry and quantitative computed tomography (QCT) after 1 yr of therapy. RESULTS: Among women treated with PTH alone, the
Dear Editor,. We read with much interest the recently published article, Effects of Raloxifene on Bone Metabolism in Hemodialysis Patients With Type 2 Diabetes, by Saito et al (1). First, we would like to congratulate the authors. We wish to share a few scientific facts related to this interesting article.. It was a pleasure to inform from this article that no difference was observed in BMD (bone mineral density) changes between patients with diabetes and nondiabetics after using raloxifene one year long.. We have previously shown that the effects of low dose HRT and raloxifene on BMD at the lumbar spine and hip sites and biochemical markers of bone turnover in a randomized trial (2). In our study, the bone mineral density measurements with dual energy Xray absorptiometry (DEXA) method is accepted by the WHO as the gold standard for the diagnosis of osteoporosis. Satoi et al. proposed the SOS value has been shown to be significantly and positively correlated with lumbar BMD in the general ...
Background: Women with type 2 diabetes mellitus (T2DM) have a higher risk of fractures despite increased bone mineral density (BMD). In experimental studies a potential role of plasminogen activator inhibitor-1 (PAI-1) in bone remodeling is suggested but studies in humans are lacking. This is a first study in humans investigating whether circulated levels of PAI-1 in postmenopausal women with T2DM are related to BMD and adiposity. Methods: Anthropometric variables, PAI-1 and insulin levels, serum lipids and bone turnover markers were measured in 127 postmenopausal women with T2DM. A total of 117 female patients were divided according to lumbar spine BMD measurements via dual-energy x-ray absorptiometry in three groups: 47 with osteopenia, 21 with osteoporosis and 49 with normal BMD. Results: Diabetic patients with normal BMD had significantly higher BMI, greater waist circumference and lower bone turnover markers than diabetics with osteopenia and osteoporosis. PAI-1 was lower in diabetics with ...
The findings could have implications for the prevention of osteoporosis.. Osteoporosis, or porous bone, is a disease in which there is a loss of bone mass and destruction of bone tissue. This process causes weakening of the bones and makes them more likely to break. The bones most often affected are the hips, spine, and wrists.. Osteoporosis affects over 10 million Americans, with women four times more likely to develop osteoporosis than men.. Another 34 million people have low bone mass and therefore have an increased risk for osteoporosis. Estrogen deficiency is one of the main causes of bone loss in women during and after menopause. Women may lose up to 20 percent of their bone mass in the five to seven years following menopause.. Premenopausal women with depression should be screened for low bone mass, says Dr. Giovanni Cizza, senior author of the study who conducted the research while at the National Institute of Mental Health (NIMH).. They should do a bone mineral density measurement, ...
Introduction:There is considerable amount of controversy about the long term effects of multiparity and duration of breast-feeding on maternal bone mineral density after menopause. This study was conducted to determine whether multiple pregnancy and prolonged duration of breast-feeding are independent predictors of low bone mass in post-menopausal Kurdish women. Methods: In a retrospective study, we evaluated 991 post-menopausal women with mean age of 58.9 years screened for osteoporosis by dual energy X-ray absorptiometry (DXA). According to the parity (1-2, 3-4, 5-7, |7 children) and total duration of breast-feeding (1-24, 25-60, 61-96, |96 months) they were classified. Bone mineral density (BMD) results for femoral neck and lumbar spine were classified into three groups (normal, osteopenia, and osteoporosis) according to the WHO criteria. Binary logistic regression was used to assess the independent associations of low femur or spine BMD with parity and total duration of breast-feeding. Results: We
Bone Density Test Some women are at greater risk for osteoporosis - the decrease of bone mass and density as a result of the depletion of bone calcium and protein - than others. Your physician can help you determine your risk of developing osteoporosis by taking your personal and family medical history, and by performing a bone density test or bone mass measurement. What is a bone density test? A bone density test, also known as bone mass measurement or bone mineral density test, measures the strength a...
01 February 2012 February 2012 - A new study has found that a drug shown to be highly effective in preventing breast cancer in women who are at high risk for the disease appears to worsen age-related bone loss, although the clinical implications of the findings are unclear.. In June 2011, the results of a Canadian-led clinical trial showed that, for postmenopausal women at increased risk of developing breast cancer, the drug exemestane reduced the risk by 65 %, compared with placebo. The new study found that exemestane worsens age-related bone loss by about three-fold compared to placebo.. The new study involved 351 postmenopausal women, with a median age of 61 years, who were not previously diagnosed with osteoporosis, were not on bone medications and were taking calcium and vitamin D supplements. The research team measured bone mineral density using high-resolution CT scans to assess the density or bone strength. After two years, the researchers found a 7.9 % loss of bone density in the ...
HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density. We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucleoside reverse transcriptase inhibitors in combination with either a protease inhibitor (PI) or a non-nucleosidic reverse transcriptase inhibitor (NNRTI), to evaluate early changes in body composition, bone mineral density and metabolic markers as differentially induced by antiretroviral therapies. We measured changes in markers of carbohydrate, of fat and bone metabolism, and, using dual-emission X-ray absorptiometry (DXA), body composition and bone mineral density (BMD). Complete data on changes between baseline and after 21 months treatment were available for 35 patients (16 in the PI group and 19 in the NNRTI group). A significant gain in BMI and in total and lower limb fat mass was recorded only in
TY - JOUR. T1 - The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. AU - Slemenda, C. W.. AU - Turner, C. H.. AU - Peacock, M.. AU - Christian, J. C.. AU - Sorbel, J.. AU - Hui, S. L.. AU - Johnston, C. C.. PY - 1996/4/12. Y1 - 1996/4/12. N2 - To estimate genetic effects on femoral neck geometry and the distribution of bone mineral within the proximal femur a cross-sectional twin analysis was carried out at a university hospital that compared correlations in these traits in pairs of mono- and dizygotic female twins. Monozygotic (MZ, n = 51 pairs, age 49.1 ± 9.3 years) and dizygotic (DZ, n = 26 pairs, age 45.7 ± 11.3 years) twins were randomly selected from a larger sample of twins previously studied. Measurements of bone mineral density (BMD), femoral neck angles and length, cross-sectional area and moment of interia, the center of mass of the narrowest cross-section of the femoral neck, and BMDs of regions within the femoral neck were made. A summary ...
Osteoporosis is a serious health concern, especially for older people. There could be nutritional deficiencies that your family members have, and that should be addressed with your doctor. Once you determine the cause of low bone density, your doctor may recommend certain supplements, such as Vitamin D, Vitamin K, and/or Calcium. A diet rich in these vitamins could potentially prevent future bone density loss and osteoporosis. Foods such as eggs, oily fish (salmon, sardines, tuna), and fortified dairy products are high in Vitamin D. For Calcium-rich foods, try adding broccoli, kale, low-fat dairy, and oily fish to your diet. Exercise has been proven to increase bone density, particularly strength training (squats, lunges, pushups), and weight lifting. Also, cardio exercises such as running/jogging, fast walking, stair climbing, jumping rope, and jump training are great bone density building sports.. ...
The IAEA assists its Member States in their efforts to develop effective, evidence based interventions to combat malnutrition in all its forms using nuclear techniques. This publication was developed as an integral part of the IAEAs efforts to contribute to the transfer of technology and knowledge in the application of a widely used nuclear technique in nutrition, dual energy X ray absorptiometry (DXA). It provides information on the theoretical background as well as on the practical application of DXA to measure bone mineral density and to assess body composition.. ...
TY - JOUR. T1 - Volumetric bone mineral density and bone structure in childhood chronic kidney disease. AU - Wetzsteon, Rachel J.. AU - Kalkwarf, Heidi J.. AU - Shults, Justine. AU - Zemel, Babette S.. AU - Foster, Bethany J.. AU - Griffin, Lindsay. AU - Strife, C. Frederic. AU - Foerster, Debbie L.. AU - Jean-Pierre, Darlene K.. AU - Leonard, Mary B.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2011/9. Y1 - 2011/9. N2 - Chronic kidney disease (CKD) is associated with increased fracture risk and skeletal deformities. The impact of CKD on volumetric bone mineral density (vBMD) and cortical dimensions during growth is unknown. Tibia quantitative computed tomographic scans were obtained in 156 children with CKD [69 stages 2 to 3, 51 stages 4 to 5, and 36 stage 5D (dialysis)] and 831 healthy participants aged 5 to 21 years. Sex-, race-, and age- or tibia length-specific Z-scores were generated for trabecular BMD (TrabBMD), cortical BMD (CortBMD), cortical area (CortArea) ...
Bruyere, Olivier ; Devogelaer, Jean-Pierre ; Delmas, Pierre D. ; Slosman, Daniel O. ; Albanese, Carlina ; et. al. Increase in femoral neck bone mineral density is associated with decrease in hip fracture incidence during treatment with strontium ranelate..70th Annual Scientific Meeting of the American-College-of-Rheumatology/41st Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals (Washington (Dc), Nov 10-15, 2006). In: Arthritis & Rheumatism, Vol. 54, no. 9, p. S586-S586 (2006 ...
TY - JOUR. T1 - Point-of-Care Phalangeal Bone Mineral Density Measurement Can Reduce the Need of Dual-Energy X-Ray Absorptiometry Scanning in Danish Women at Risk of Fracture. AU - Holmberg, Teresa. AU - Bech, Mickael. AU - Gram, Jeppe. AU - Hermann, Anne Pernille. AU - Rubin, Katrine Hass. AU - Brixen, Kim. PY - 2016/3. Y1 - 2016/3. N2 - Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral density (BMD), and to define triage thresholds for pre-selection. Total hip and lumbar spine BMD was measured by dual-energy X-ray absorptiometry and phalangeal BMD by radiographic absorptiometry in 121 Danish women with intermediate or high 10-year fracture probability (aged 61-81 years). Correlation between the two methods was estimated using ...
TY - JOUR. T1 - Increases in hip and spine bone mineral density are predictive for vertebral antifracture efficacy with ibandronate. AU - Miller, Paul D.. AU - Delmas, Pierre D.. AU - Huss, Hermann. AU - Patel, Katie M.. AU - Schimmer, Ralph C.. AU - Adami, Silvano. AU - Recker, Robert R.. PY - 2010/10/1. Y1 - 2010/10/1. N2 - The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandronate. Outcome measures included moving averages plots and logistic regression analyses of the relationship between BMD change and vertebral fracture rate. In moving averages plots, ibandronate-induced BMD gains were consistently associated with decreased fracture rates. In the oral study, total-hip BMD increases at years 2 and 3 and lumbar spine BMD increases ...
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TY - CONF. T1 - Liver disease severity and low bone mineral density in HIV mono-infected and HIV/HCV co-infected patients. AU - Rini, Giovam Battista. AU - Titone Lanza Di Scalea, Lucina. AU - Di Carlo, Paola. AU - Giannitrapani, Lydia. AU - Montalto, Giuseppe. AU - Tramuto, Fabio. AU - Soresi, Maurizio. AU - Midiri, Massimo. AU - Li Vecchi, Valentina. PY - 2014. Y1 - 2014. N2 - Background: In this study we assess: prevalence of osteopenia, osteoporosis and reduced bone mineral density in HIV infection and HIV / HCV co-infection;risk factors associated with reduced bone mineral density(BMD); relationship between bone mineral density and reduced liver fibrosis (FE) measured as liver stiffness (LS), by FibroScan ® in patients co-infected with HIV / HCV; relationship between reduced bone mineral density and cardiovascular risk assessed with the 10-year Framingham risk score (FRS) in HIV / HCV co-infected Patients And Methods: One hundred and ninety-four HIV-infected subjects (121 males =62% and ...
OBJECTIVES: To investigate the possible association between vitamin D receptor genotype and bone mineral density in a large group of postmenopausal twins. DESIGN: Cross sectional twin study. SETTING: Twin population based in Britain. SUBJECTS: 95 dizygotic (non-identical) pairs of twins and 87 monozygotic (identical) pairs of twins aged 50-69 years, postmenopausal, and free of diseases affecting bone, recruited from a national register of twins and with a media campaign. MAIN OUTCOME MEASURES: Bone mineral density measured at the hip, lumbar spine, forearm, and for the whole body by dual energy x ray absorptiometry in relation to differences in the vitamin D receptor genotype. RESULTS: At all sites the values of bone density among dizygotic twins were more similar in those of the same vitamin D receptor genotype than in those of differing genotype, and the values in the former were closer to the correlations seen in monozygotic twins. Women with the genotype that made them at risk of osteoporotic
Choice of normative database and number of skeletal sites considered had a substantial effect on the estimated prevalence of osteoporosis in older men in this study; a fourfold increase in the prevalence occurred when we defined osteoporosis by using NOF (male normative database, three skeletal sites) instead of WHO (female normative database, one skeletal site) criteria. These findings are in agreement with most,12 35 39 40 but not all,11 previous studies. Use of a female derived bone mineral density T score threshold to define osteoporosis in men is supported by a meta-analysis that reported similar relative risks of fracture per unit decrease in femoral neck bone mineral density in men and women and similar age adjusted hip fracture rates in men and women for any given absolute value of femoral neck bone mineral density.41 Both the NOF and the Endocrine Society in the United States recommend use of male derived bone mineral density T score thresholds.7 8 9 In contrast, the International ...
One of the main determinants of who will develop osteoporosis is the amount of bone accumulated at peak bone density. There is poor agreement, however, on when peak bone density occurs. Ethnic differences were observed in age at peak bone density and their correlates. Since the diagnosis of osteoporosis and osteopaenia is based on the comparison between patients bone mineral density (BMD) and optimal peak bone density in healthy young people (T-score), it is of great importance that each country should provide its own reference peak bone density data.. This review article presents our published results on peak bone density in Croatia and compares them with findings in other populations. Our research included 18 to 25-year-old students from Zagreb University and their parents. The results showed that peak bone mass in young Croatian women was achieved before the age of twenty, but BMD continued to increase after the mid-twenties in the long-bone cortical skeleton. BMD was comparable to the ...
TY - JOUR. T1 - Randomized controlled trial of alendronate in airways disease and low bone mineral density. AU - Smith, B. J.. AU - Laslett, L. L.. AU - Pile, K. D.. AU - Phillips, P. J.. AU - Phillipov, G.. AU - Evans, S. M.. AU - Esterman, A. J.. AU - Berry, J. G.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background:Patients with airways disease have been demonstrated to be at risk of osteoporosis, and this is likely to be multifactorial. Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. Method:Subjects with hip or lumbar spine baseline T-scores ,-2.5, or Z-score ,-1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. BMD by dual emission X-ray absorptiometry (lumbar vertebrae 2-4, neck of femur, total femur) was repeated after 12 months, with adverse events recorded. Results: 145 subjects (74 male, 71 female, mean age 67, median FEV, ...
Dalla Via, J., Daly, R. and Fraser, S. 2018, The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis, Osteoporosis international, vol. 29, no. 2, pp. 287-303, doi: 10.1007/s00198-017-4237-3. ...
Low bone mineral density has been identified as a risk factor for osteoporotic fracture1 and fracture in childhood.2 Vitamin D supplementation in childhood may be a clinical strategy to maximise peak bone mass in children and, in turn, improve bone mineral density and reduce fracture risk in adulthood. However, the effectiveness of vitamin D supplementation for improving bone density in children is unclear. Therefore, Winzenberg and colleagues performed a systematic review and meta-analysis to evaluate the efficacy of vitamin D supplementation for improving paediatric bone mineral density, including how supplement dose and baseline vitamin D status may impact the outcome.. ...
TY - JOUR. T1 - Continuous antiretroviral therapy decreases bone mineral density. AU - Grund, Birgit. AU - Peng, Grace. AU - Gibert, Cynthia L.. AU - Hoy, Jennifer F.. AU - Isaksson, Rachel L.. AU - Shlay, Judith C.. AU - Martinez, Esteban. AU - Reiss, Peter. AU - Visnegarwala, Fehmida. AU - Carr, Andrew D.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2009/7. Y1 - 2009/7. N2 - OBJECTIVES: To assess the effects of antiretroviral therapy (ART) on bone mineral density (BMD) DESIGN: Randomized comparison of continuous ART (viral suppression group; VS) with intermittent ART (drug conservation group; DC) SETTING: Outpatient clinics in the United States, Australia, and Spain. PARTICIPANTS: Participants in the Strategies for Management of Antiretroviral Therapy (SMART) Body Composition substudy. MAIN OUTCOME MEASURES: Annual hip and spine BMD by dual-energy radiographic absorptiometry (DXA) and spine BMD by quantitative computed tomography (qCT). METHODS: Comparisons were by ...
BACKGROUND: Infliximab has been shown to have beneficial effects on bone metabolism in patients with Crohns disease (CD) although as yet the exact mechanisms have not been fully elucidated. AIM: To evaluate the impact of adalimumab therapy on bone metabolism using a combined in vivo and in vitro model. METHODS: Parathyroid hormone, vitamin D, bone formation markers, bone resorption marker, pro-inflammatory cytokines, anti-inflammatory cytokines, osteoprotegerin, and sRANKL were measured in control patients and pre- and post-treatment with adalimumab in CD patients. The effect of control patients and pre- and post-treatment CD patients sera on human osteoblasts (hFOB 1.19) in vitro cell viability and differentiation was also analyzed. RESULTS: There was a significant increase in bone formation markers osteocalcin (P | 0.05) and procollagen type 1 N-terminal propeptide (P | 0.01) at 1 and 3 months post-treatment. Moreover, there was a sustained but not significant fall in serum CTx, a bone resorption
TY - JOUR. T1 - Dual-energy X-ray absorptiometry in the lumbar spine, proximal femur and distal radius in children. AU - Tsukahara, Hirokazu. AU - Sudo, M.. AU - Umezaki, M.. AU - Hiraoka, M.. AU - Yamamoto, K.. AU - Ishii, Y.. AU - Haruki, S.. PY - 1992/12. Y1 - 1992/12. N2 - Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) in the lumbar spine, proximal femur and distal radius in 48 Japanese children aged 3-18 years. In the normal children (n=32), BMD increased with age in all locations, with a nearly twofold increase from preschool age to adolescence. Most of the children with chronic diseases known to affect vone metabolism (e.g., steroid osteoporosis) (n=16) had low BMD in every region, indicating that these disease states probably affect multiple sites of the skeleton in children.. AB - Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) in the lumbar spine, proximal femur and distal radius in 48 Japanese children aged 3-18 years. ...
Puberty is a time when the foundation is laid for healthy bone mass. Over the course of puberty, 26% of bone mass is established in the 4-year period of peak height velocity and up to 60% of adult peak bone mass is established. Factors that affect normal bone mineralization include calcium intake, vitamin D status, degree of physical and weight bearing activities, hormones, genetics, body weight, and general health and nutrition status. HIV-infected children, youth, and adults have lower bone mineral density (BMD) than would be expected for healthy people of similar age, weight, and race. As the majority of perinatally HIV-infected U.S. children are entering or in adolescence, the potential for HIV-related impaired BMD during the adolescent peak of bone mass acquisition is of particular concern. The purpose of this study was to compare changes in BMD of the lumbar spine from pre-treatment levels to 24 and 48 weeks after alendronate treatment or placebo in HIV-infected children and ...
TY - JOUR. T1 - Sequential changes in bone density before and after parathyroidectomy in primary hyprparathyroidism. AU - Leppla, D. C.. AU - Snyder, W.. AU - Pak, C. Y C. PY - 1982/1/1. Y1 - 1982/1/1. N2 - Bone density (bone mineral content/bone width) was determined by iodine-125 (12SI)-photon absorptiometry in the distal third of the radius before and after successful parathyroidectomy in 37 patients with primary hyperparathyroidism. Bone density progressively declined during the two years immediately preceding surgery. It rose by 6.4% during the first year following surgery but remained stable thereafter. The results suggest that photon absorptiometry analysis of bone density may disclose continuing bone loss before surgery and may show a partial recovery of bone loss that may ensue after successful parathyroidectomy.. AB - Bone density (bone mineral content/bone width) was determined by iodine-125 (12SI)-photon absorptiometry in the distal third of the radius before and after successful ...
Introduction Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely affect bone. Our a priori hypothesis was that bone mineral density was lower in sleepdeprived (6.5-10 h/night) individuals. Methods Cross-sectional analysis of sleep and bone data on 1,146 individuals (652 women) was performed. Measurements were obtained at the distal radius by pQCT, and the spine and hip by DXA. Bone differences between sleepdeprived and sleep-adequate groups were compared after stratifying by sex and controlling for covariates. Results Overall, 19% of the population was sleep deprived. Sleep-deprived women had lower cortical volumetric BMD (1, 208±4 vs. 1, 219±2 mg/cm3, P=0.03) than sleep-adequate women. Sleep-deprived men had lower pSSI, an estimate of torsional bending strength, than sleep-adequate men (358± 10 vs. 382±5 mm3, P=0.04), due to a slightly smaller periosteal circumference (43.9±0.4 vs. 44.8±0.2 mm, P=0.07) and cortical area
Bone densitometry is used to measure the bone mineral content and density. This measurement can indicate decreased bone mass, a condition in which bones are more brittle and more prone to break or fracture easily. Bone densitometry is used primarily to diagnose osteoporosis and to determine fracture risk. The testing procedure measures the bone density of the bones of the spine, pelvis, lower arm, and thigh.. Bone densitometry testing may be done using X-rays, dual-energy X-ray absorptiometry, (DEXA or DXA), or by quantitative CT scanning using special software to determine bone density of the hip or spine. These procedures are generally done in a clinic, hospital, or free-standing radiology facility.. However, for mass screening purposes, there are portable types of bone densitometry testing. The portable testing is done using either a DEXA (or DXA) X-ray device or a quantitative ultrasound unit. Both types of portable testing may use the radius (one of the two bones of the lower arm), wrist, ...
TY - JOUR. T1 - Oral contraceptive use and bone density change in adolescent and young adult women. T2 - A prospective study of age, hormone dose, and discontinuation. AU - Scholes, Delia. AU - Hubbard, Rebecca A.. AU - Ichikawa, Laura E.. AU - LaCroix, Andrea Z.. AU - Spangler, Leslie. AU - Beasley, Jeannette M.. AU - Reed, Susan. AU - Ott, Susan M.. PY - 2011/9/1. Y1 - 2011/9/1. N2 - Context: Oral contraceptive (OC) use is common, but bone changes associated with use of contemporary OC remain unclear. Objective: The objective of the study was to compare bone mineral density (BMD) change in adolescent and young adultOCusers and discontinuers of two estrogen doses, relative to nonusers. Design and Setting: This was a prospective cohort study, Group Health Cooperative. Participants: Participants included 606 women aged 14-30 yr (50% adolescents aged 14-18 yr): 389 OC users [62% 30-35 μg ethinyl estradiol (EE)] and 217 age-similar nonusers; there were 172 OC discontinuers. The 24-month retention ...
URL: https://www.mdpi.com/2411-5142/3/4/62. Journal: Journal of Functional Morphology and Kinesiology. Publication Date: 12/2018. Summary: Exercise-trained female subjects that consume a diet that is approximately three times greater than the RDA for protein experience no harmful effects on bone mineral density or content. Nor were there any harmful effects on renal function.. ...
TY - JOUR. T1 - Comparison of the male osteoporosis risk estimation score (MORES) with frax in identifying men at risk for osteoporosis. AU - Cass, Alvah R.. AU - Shepherd, Angela. AU - Asirot, Rechelle. AU - Mahajan, Manju. AU - Nizami, Maimoona. PY - 2016/7/1. Y1 - 2016/7/1. N2 - PURPOSE We wanted to compare the male osteoporosis risk estimation score (MORES) with the fracture risk assessment tool (FRAX) in screening men for osteoporosis. METHODS This study reports analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of the US population, comparing the operating characteristics of FRAX and MORES to identify men at risk for osteoporosis using a subset of 1,498 men, aged 50 years and older, with a valid dual-energy x-ray absorptiometry (DXA) scan. DXA-derived bone mineral density using a T score of -2.5 or lower at either the femoral neck or total hip defined the diagnosis of osteoporosis. Outcomes included the ...
INTRODUCTION: gonadal steroid hormones play a crucial role during skeletal growth and maturation in both men and women. The aim of this study is to evaluate the relationship of sex hormone levels, bone mineral density and biochemical markers of bone turnover in healthy Moroccan men. METHODS: 142 Moroccan men who had no previous diagnosis of osteoporosis were enrolled prospectively in this cross-sectional study between December 2009 and August 2010. Also, subjects were excluded from the study if they had conditions affecting bone metabolism. Different biochemical parameters were assayed: Testosterone, Estradiol, sex hormone binding globulin, Osteocalcin, vitamin D, crosslaps, intact parathyroid hormone and alkaline phosphatase. Dual-energy X-ray absorptiometry was used to measure the Bone mineral density (BMD) (g/cm2). RESULTS: in this study, among the 142 Moroccan men, 29 (20.1%) had densitometry osteoporosis and the prevalence of vitamin D insufficiency was 94%. No correlation was found between
PubMed journal article Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective stud were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
TY - JOUR. T1 - Effect of testosterone treatment on volumetric bone density and strength in older men with low testosterone a controlled clinical trial. AU - Snyder, Peter J.. AU - Kopperdahl, David L.. AU - Stephens-Shields, Alisa J.. AU - Ellenberg, Susan S.. AU - Cauley, Jane A.. AU - Ensrud, Kristine E.. AU - Lewis, Cora E.. AU - Barrett-Connor, Elizabeth. AU - Schwartz, Ann V.. AU - Lee, David C.. AU - Bhasin, Shalender. AU - Cunningham, Glenn R.. AU - Gill, Thomas M.. AU - Matsumoto, Alvin M.. AU - Swerdloff, Ronald S.. AU - Basaria, Shehzad. AU - Diem, Susan J.. AU - Wan, Christina. AU - Hou, Xiaoling. AU - Cifelli, Denise. AU - Dougar, Darlene. AU - Zeldow, Bret. AU - Bauer, Douglas C.. AU - Keaveny, Tony M.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - IMPORTANCE As men age, they experience decreased serum testosterone concentrations, decreased bone mineral density (BMD), and increased risk of fracture. OBJECTIVE To determine whether testosterone treatment of older men with low testosterone ...
We conducted a genome-wide association study of low bone mineral density (BMD) at the hip and spine utilizing sequence variants found through whole-genome sequencing of 2636 Icelanders. We found two rare missense mutations, p.Gly496Ala and p.Gly703Ser, in the COL1A2 gene that associate with measures of osteoporosis in Icelanders. Mutations in COL1A2 are known to cause the autosomal dominant disorder osteogenesis imperfecta. Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 x 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 x 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]). Association with fractures was p = 2.2 x 10(-5) , OR = 3.75 (95% CI 2.03, 6.93) and p = 0.0023, OR = 4.32 (95% CI 1.69, 11.1), respectively. The carriers of these variants do not have signs of
Design and methods. Part A of the Safe-D study is a cross-sectional study aiming to recruit 468 young females aged 16-25 years living in Victoria, Australia, through Facebook advertising. Participants are required to complete an extensive, online questionnaire, wear an ultra-violet dosimeter for 14 consecutive days and attend a study site visit. Outcome measures include areal bone mineral measures at the lumbar spine, total hip and whole body, as well as soft tissue composition using dual energy x-ray absorptiometry. Trabecular and cortical volumetric bone density at the tibia is measured using peripheral quantitative computed tomography. Other tests include serum 25-hydroxyvitamin D, serum biochemistry and a range of health markers. Details of mood disorder/s and depressive and anxiety symptoms are obtained by self-report. Cutaneous melanin density is measured by spectrophotometry ...
Background: It is not known whether the recently described break in the trend in hip fracture incidence in many settings applies in both women and men, depends on changes in bone mineral density (BMD) or changes in other risk factors, or whether it is apparent in both urban and rural settings. Methods: We evaluated changes in annual hip fracture incidence from 1987 to 2002 in Swedish men aged ≥60 years in one urban (n=25,491) and one rural population (n=16,432) and also secular differences in BMD, measured by single-photon absorptiometry at the distal radius and multiple other risk factors for hip fracture in a population-based sub-sample of the urban and the rural men aged 60-80 years in 1988/89 (n=202 vs. 121) and in 1998/99 (n=79 vs. 69). Results: No statistically significant changes in the annual age-adjusted hip fracture incidence per 10,000 were apparent from 1987 to 2002 in urban (0.38 per year, 95% CI-0.12 to 0.88) or rural men (-0.05 per year, 95% CI -0.63 to 0.53). BMD was similar in ...
As osteopenia and osteoporosis deteriorate physical functions, the person becomes less capable of walking and the risk of injuries from a fall increases. An injury from a fall may lead to fracture and hospitalization. As a result, deterioration of osteopenia and osteoporosis causes loss of physical functions even to the point of death. Thus, effective solutions are to be developed (Shahin et al., 2010). One way of preventing and controlling osteopenia and osteoporosis is an exercise therapy to improve the bone density. For example, a type of training that induces physical stress to osseous tissues such as weight or load bearing exercise is recommended. This type of training delays the reduction of bone density and even increases bone mass (Rittweger et al., 2000). Bone mass is an index that reflects the level of bone density. It is not only an important element for diagnosis of osteopenia and osteoporosis but also a predictive factor for the determine the risk of fracture. A bone density test is ...
The purpose of this study was to determine the relationships among hip geometry, bone mineral density, and the risk of hip fracture in premenopausal women. The participants in this case-control study were 16 premenopausal women with minimal-trauma hip fractures (fracture group) and 80 age-and BMI-adjusted controls. Subjects underwent dual-energy X-ray absorptiometry (DXA) to assess BMD at the proximal femur and to obtain DXA-derived hip geometry measurements. The fracture group had a lower mean femoral neck and total hip BMD than the control group (0.721 ± 0.123 vs. 0.899 ± 0.115, p |0.001 for the femoral neck BMD and 0.724 ± 0.120 vs. 0.923 ± 0.116, p |0.001 for the total hip BMD). In addition, participants in the fracture group had a longer hip axis length (HAL; p = 0.007), narrower neck shaft angle (NSA; p = 0.008), smaller cross sectional area (CSA; p | 0.001) and higher cross sectional moment of inertia (CSMI; p = 0.004) than those in control group. After adjusting for BMD, the fracture group
Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detect bone tissue property changes early after glucocorticoid treatment initiation. After initial laboratory and bone density measurements, patients were allocated into groups receiving calcium+vitamin D (Ca+D) supplements or anti-osteoporotic drugs (risedronate, denosumab, teriparatide). Reference point indentation was performed on the cortical bone layer of the tibia by a handheld device measuring bone material strength index (BMSi). Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA). Although Ca+D-treated patients exhibited substantial and significant deterioration, ...
The aim of this study was to establish, by means of peripheral quantitative computed tomography (pQCT) at the distal radius, the existence of cortical and/or trabecular osteopenia, and to assess the integrity of bone geometry in uremic patients undergoing maintenance hemodialysis. Our results show a clearcut selective reduction in volumetric cortical density, more evident in women (p = -0.0001) than men (p = 0.030), which appears to be independent of age and menopausal status. Trabecular density was not significantly changed in either sex. Cortical density of the patients correlated inversely with age (p = 0.003), duration of dialysis (p = 0.002) and parathyroid hormone (PTH) levels (p = 0.03). Trabecular density correlated only with age. Normally, cortical density is age-dependent and its reduction is accompanied by compensatory geometry changes. Compared with control subjects, in our female patients both cortical area and cortical thickness were reduced (p = 0.02 and 0.008), while ...
A FRAX model for Canada was constructed for prediction of osteoporotic and hip fracture risk using national hip fracture data with and without the use of femoral neck bone mineral density (BMD). Performance of this system was assessed independently in a large clinical cohort of 36,730 women and 2873 men from the Manitoba Bone Density Program database that tracks all clinical dual-energy X-ray absorptiometry (DXA) test results for the Province of Manitoba, Canada. Linkage with other provincial health databases allowed for the direct comparison of fracture risk estimates from the Canadian FRAX model with observed fracture rates to 10 years (549 individuals with incident hip fractures and 2543 with incident osteoporotic fractures). The 10-year Kaplan-Meier estimate for hip fractures in women was 2.7% [95% confidence interval (CI) 2.1-3.4%] with a predicted value of 2.8% for FRAX with BMD, and in men the observed risk was 3.5% (95% CI 0.8-6.2%) with predicted value of 2.9%. The 10-year estimate of
Patients with congenital adrenal hyperplasia attributable to 21-hydroxylase deficiency are treated with glucocorticoids. Glucocorticoid administration, even in substitution doses, may cause decreased bone mineral density (BMD) and obesity. The purpose of this study was to determine BMD, lean mass, a …
The Global Bone Density Test Market is expected to grow at a CAGR of 7.2% during the forecast period. Bone density test determines the density of bones and chances of the bone being broken. Central dual-energy X-ray absorptiometry (DXA) test is recommended for testing the bone density of hip and spine. Bone density test used in the diagnosis of osteoporosis, and osteopenia. The osteoporosis mostly occurs in women after the menopause but may also be present in males. The condition is less common in adults and children.. Read Exclusive Sample Report @ https://www.marketresearchfuture.com/sample_request/4766 .. Rising prevalence of osteoporosis, osteopenia, hyperthyroidism, and increasing demand for portable bone testing devices drive the market growth. Furthermore, the demand for diagnosis and treatment measures for osteoporosis also influence the market growth. Additionally, the demand for technologically advanced devices drives the market growth.. According to the International Osteoporosis ...
The physiological role of GH in the adult skeleton is unknown. In this study, 12 adults (10 males and 2 females) with isolated GH deficiency were treated with GH as a single daily sc injection (0.125 IU/kg.week for the first 4 weeks and subsequently at 0.25 IU/kg.week) for 1 yr in a double blind, placebo-controlled manner. Bone mineral density of the spine (T12-L3) was measured by quantitative computed tomography, and bone mineral content (BMC) of the forearm by single photon absorptiometry at entry into the study and subsequently at 6 monthly intervals. All baseline bone mineral measurements were reduced compared with those in an age- and sex-matched control population. In the treatment cohort, quantitative computed tomography spinal trabecular bone mineral density increased by 7.8 g/L after 6 months of GH replacement (mean +/- SEM, 151.7 +/- 6.0 vs. 159.5 +/- 5.9 g/L; n = 11; P , 0.01), and this increment was maintained at 1 yr (160.7 +/- 6.3 g/L). Proximal forearm (cortical) BMC showed no ...
2014 American Society for Bone and Mineral Research. The relationship between body mass index (BMI) and fracture risk is controversial. We sought to investigate the effect of collinearity between BMI and bone mineral density (BMD) on fracture risk, and to estimate the direct and indirect effect of BMI on fracture with BMD being the mediator. The study involved 2199 women and 1351 men aged 60 years or older. BMI was derived from baseline weight and height. Femoral neck BMD was measured by dual-energy X-ray absorptiometry (DXA; GE-LUNAR, Madison, WI, USA). The incidence of fragility fracture was ascertained by X-ray reports from 1991 through 2012. Causal mediation analysis was used to assess the mediated effect of BMD on the BMI-fracture relationship. Overall, 774 women (35% of total women) and 258 men (19%) had sustained a fracture. Approximately 21% of women and 20% of men were considered obese (BMI ≥ 30). In univariate analysis, greater BMI was associated with reduced fracture risk in women ...
TY - JOUR. T1 - Locally measured microstructural parameters are better associated with vertebral strength than whole bone density. AU - Hazrati Marangalou, J.. AU - Eckstein, F.. AU - Kuhn, V.. AU - Ito, K.. AU - Cataldi, M.. AU - Taddei, F.. AU - Van Rietbergen, B.. PY - 2014. Y1 - 2014. N2 - Summary: Whole vertebrae areal and volumetric bone mineral density (BMD) measurements are not ideal predictors of vertebral fractures. We introduce a technique which enables quantification of bone microstructural parameters at precisely defined anatomical locations. Results show that local assessment of bone volume fraction at the optimal location can substantially improve the prediction of vertebral strength. Introduction: Whole vertebrae areal and volumetric BMD measurements are not ideal predictors of vertebral osteoporotic fractures. Recent studies have shown that sampling bone microstructural parameters in smaller regions may permit better predictions. In such studies, however, the sampling location ...
The vitamin D receptor (VDR) was the first candidate gene to be studied in relation to osteoporosis, and most attention has focused on polymorphisms situated near the 3 flank of VDR. The aim of this study was to investigate the association about VDR gene Apa I polymorphism with bone mineral density (BMD) in postmenopausal women with osteoporosis. We studied a total of 136 postmenopausal women with a mean age of 56.36 +/- 10.29 years. Among them, a total of 75 had osteoporosis, 37 had osteopenia, and 24 had normal BMD. Venous blood samples were obtained for evaluation of bone metabolism and genotyping. The VDR Apa I genotype was determined by polymerase chain reaction-restriction fragment length polymorphism. BMDs at the lumbar spine and hip were measured by dual-energy X-ray absorptiometry. Postmenopausal women with aa genotype had significantly lower BMD values (grams per centimeter square) at lumbar spines compared to persons with AA genotype. Also, postmenopausal women with AA genotype had ...
Sclerostin is a secreted Wnt antagonist produced almost exclusively by osteocytes that regulates bone mass. However, there is currently limited information on the determinants of sclerostin in a large population-based study. The main objectives of the present study were to: (1) establish reference normative interval values for serum sclerostin in randomly selected healthy premenopausal women; (2) study the changes in serum sclerostin in relation to age in premenopausal and postmenopausal women and the factors that may influence bone turnover; and (3) determine the effect of menopausal status on serum sclerostin. A total of 1803 women were studied (including [n = 1235] premenopausal, and [n = 568] postmenopausal women, respectively, aged 20 to 79 years). A total of 443 healthy premenopausal women (aged 35 to 45 years) were used to establish reference normative intervals for serum sclerostin. All women studied were medically examined and had their bone mineral density values obtained for the ...
TY - JOUR. T1 - The Effects of Estrone (Ogen) on Spinal Bone Density of Postmenopausal Women. AU - Harris, Steven T.. AU - Genant, Harry K.. AU - Baylink, David J.. AU - Gallagher, J. Christopher. AU - Karp, Sherry Katz. AU - Mcconnell, Maureen A.. AU - Green, Elizabeth M.. AU - Stoll, Ralph W.. PY - 1991/10. Y1 - 1991/10. N2 - The effects of cyclical treatment with estrone sulfate (0.3, 0.625, or 1.25 mg), plus calcium carbonate, on spinal trabecular bone density were compared with placebo in 120 postmenopausal women in this 2-year, multicenter, doubleblind study. While the placebo and 0.3-mg treatment groups lost bone density (-3.6% and -5.1%), the 0.625- and 1.25-mg treatment groups experienced no significant change from baseline at 24 months (-0.8% and +0.7%). The 1.25-mg treatment group was significantly different from the placebo group at 12,18, and 24 months. Although the 0.625-mg treatment group was significantly different from the placebo group only at 18 months, the data suggest that ...
Dietary protein is theorized to hold both anabolic effects on bone and demineralizing effects mediated by the diet acid load of sulfate derived from methionine and cysteine. The relative importance of these effects is unknown but relevant to osteoporosis prevention. Postmenopausal women (n = 161, 67.9 +/- 6.0 y) were assessed for areal bone mineral density (aBMD) of lumbar spine (LS) and total hip (TH) using dual X-ray absorptiometry, and dietary intakes of protein, sulfur-containing amino acids, and minerals using a USDA multiple-pass 24-h recall. The acidifying influence of the diet was estimated using the ratio of protein:potassium intake, the potential renal acid load (PRAL), and intake of sulfate equivalents from protein. aBMD was regressed onto protein intake then protein was controlled for estimated dietary acid load. A step-down procedure assessed potential confounding influences (weight, age, physical activity, and calcium and vitamin D intakes). Protein alone did not predict LS aBMD (P ...
Background: Adult subjects with Prader-Willi Syndrome (PWS) have low Bone Mineral Density (BMD) and are at risk of osteoporosis. Several observations suggest that peak bone mass is usually achieved by late adolescence, in the presence of adequate gonadal hormone concentrations. Consequently, the altered bone characteristics of PWS patients may be related to inadequate sex steroid levels during pubertal development.. Aim: To investigate BMD in PWS females during the transition phase.. Methods: Thirty-two females with genetically confirmed PWS, aged 22.1±0.4 year (mean+SE) (range 17.9 25.0 year), were studied. Eleven subjects were undergoing sex steroids therapy (Group A), while the remaining 21 individuals were naïve to substitutive treatment (Group B). Twenty subjects had undergone GH treatment during childhood. In all patients dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy) was used to measure BMD in the lumbar spine L1-L4 (gr/cm2), BMD T-score, and BMD Z-score.. Results: Four PWS had ...