TY - JOUR. T1 - Fatal cerebral hemorrhage in a patient with CD19-positive Igm-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. AU - Alatoom, Adnan. AU - Elsabrouty, Rania. AU - Willis, Jason. AU - Boils, Christie. AU - Sarode, Ravindra. AU - Hashim, Ibrahim. AU - Wang, Huan You. PY - 2009. Y1 - 2009. N2 - IgM plasma cell myeloma (PCM) is a rare entity, and CD19 positivity is found in only 1-4% of PCM. Here we report a unique case of IgM PCM, in which the plasma cells are positive for CD19. Clinically, the patient presented with hyperviscosity syndrome, mimicking the clinical manifestation of Waldenstroms macroglobulinemia. In addition, the IgM para-protein from the patient behaved like cryoglobulins, which interfered with some of the laboratory measurements and resulted in erroneous platelet count, mean platelet volume, and serum IgM level. Despite chemotherapy, the PCM persisted and progressed to plasma cell leukemia, and the patient died of a left ...
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Two patients had Sjögrens syndrome and chronic polysynovitis that had caused neither deformity nor bony erosions. Both patients had increased serum viscosity, and one patient had the hyperviscosity syndrome. Increased serum viscosity correlated with the presence of intermediate complexes that seem to be formed by interactions between IgG antigen and IgG rheumatoid factor. Neither the occurrence of the hyperviscosity syndrome in Sjögrens syndrome nor the association of hyperviscosity with circulating serum IgG-IgG rheumatoid factor complexes has been previously reported. ...
Hyperviscosity syndrome (HVS) refers to the clinical sequelae of increased blood viscosity. Increased serum viscosity usually results from increased circulating serum immunoglobulins and can be seen in such diseases as Waldenström macroglobulinemia and multiple myeloma.
Rheology - the study of the flow of matter and accompanying phenomena of real bodies deformation - in relation to blood - hemorheology. Blood viscosity - the main rheological parameter - has been studied in many research centers and among many different group of patients. The main disorders related to the hemorheological properties are: coronary insufficiency, vascular congestion, myocardial infarction, cerebral circulation disorder, Reynaud disease, ischemic limbs, diabetes, anemia, tumors. The following parameters are the main blood viscosity determinants: plasma viscosity, hematocrit, red cell deformability and erythrocytes aggregation. In hemorheological studies we used mathematical rheological models. The measurements of blood and plasma viscosity are performed by means of oscillating-rotary rheometers in order to determine the dependence of blood viscosity on the shear rate and the two components of the complex blood viscosity. Determination of blood cells aggregability and deformability ...
TY - JOUR. T1 - Hemorheological parameters in coronary artery disease. AU - Kesmarky, G.. AU - Toth, K.. AU - Habon, L.. AU - Vajda, G.. AU - Juricskay, I.. PY - 1998/7/1. Y1 - 1998/7/1. N2 - Hemorheological parameters are primary risk factors in ischemic heart disease (IHD). In the present study the relation of these parameters to the severity of coronary artery disease (CAD) was examined. The data of 109 patients (mean age: 55 ± 9 years) undergoing coronary angiography and 59 healthy controls (mean age: 35 ± 10 years) were analyzed. Hemorheological parameters (hematocrit, fibrinogen level, plasma viscosity (PV) and apparent whole blood Viscosity (WBV)) were determined and the circulatory index (CRI) was calculated. Patients were classified into three groups according to their coronary vessel state based on the coronary angiogram: Group 1 (n = 19, mean age: 53 ± 8 years) without significant CAD, Group 2 (n = 19, mean age: 51 ± 11 years) with single vessel disease, Group 3 (n = 71, mean age: ...
50% of patients had 1 α-gene deleted (−α3.7 deletion). In agreement with previous studies,1,9 they exhibited lower mean cell volume, higher hematocrit and hemoglobin, increased RBC deformability, decreased RBC aggregates strength (P,0.05 for all parameters) and similar blood viscosity compared to patients without α-thalassemia (data not shown). The magnitude of the hematological/hemorheological responses under HU treatment was similar in the two groups, except for hemoglobin (+16 vs. +8%, P,0.05), hematocrit (+23 vs. +11%, P,0.05), the hematocrit/blood viscosity ratio (+34 vs. +8%, P,0.05) and RBC deformability (at 30 Pa: +65 vs. +26%, P,0.05), which increased more in patients without α-thalassemia than in patients with it. The effect of HU on the decrease of the number of VOC/STA events was similar in the two subgroups.. In agreement with previous studies, HU significantly decreased the rates of hospitalization for VOC and ACS in SCA patients who frequently exhibited these ...
Synonyms for viscous resistance in Free Thesaurus. Antonyms for viscous resistance. 46 synonyms for resistance: opposition, hostility, aversion, refusal to accept, lack of enthusiasm for, reluctance to accept, fighting, fight, battle, struggle. What are synonyms for viscous resistance?
There is still considerable controversy regarding the influence of blood viscosity upon CBF. We have measured CBF with microspheres in 23 cats. Autoregulation was disturbed in the left caudate nucleus by microsurgical occlusion of the left middle cerebral artery. Induced hypertension or hypotension was used and i.v. mannitol (1 g/kg) administered. In all cats blood viscosity decreased an average of 16% at 15 minutes and, in 16 cats, increased 10% at 75 minutes post-mannitol. CBF in the right caudate was 79 +/- 6 ml/100g/min, in the left 38 +/- 6 (p less than 0.001). Only minor changes of CBF occurred in areas with presumed normal autoregulation, including the right caudate, in conjunction with pressure or viscosity changes. In the left caudate CBF decreased 21% with hypotension and 18% with higher viscosity, more than on the right (p less than 0.01 and p less than 0.2, respectively). CBF increased in the left caudate 56% with hypertension and 47% with lower viscosity, again much more than on the ...
TY - JOUR. T1 - Determination of the blood viscosity and yield stress with a pressure- scanning capillary hemorheometer using constitutive models. AU - Lee, Byung Kwon. AU - Xue, Shubin. AU - Nam, Jeonghun. AU - Lim, Hyunjung. AU - Shin, Sehyun. PY - 2011/3/1. Y1 - 2011/3/1. N2 - We investigated the applicability of two non-Newtonian constitutive models (Casson and Herschel-Bulkley models) in the determination of the blood viscosity and yield stress using a pressure-scanning microfluidic hemorheometer. The present results were compared with the measurements through a precision rheometer (ARES2). For a Newtonian fluid (standard oil), the two constitutive models showed excellent agreement with a reference value and the measurement of ARES2. For human blood as a non-Newtonian fluid, both the Casson and Herschel-Bulkley models exhibited similar viscosity results over a range of shear rates and showed excellent agreement with the ARES2 results. The Herschel-Bulkley model yielded a slightly higher ...
Abstract. Rheologic properties of blood were studied in 8 patients with dilated cardiomyopathy (DCM) and in 10 healthy subjects. Whole-blood viscosity was measured at four different shear rates, by means of a computer-controlled rotational viscometer. The patients had significantly higher blood viscosity at all shear rates, both at their natural hematocrits and after an in vitro adjustment of sample hematocrits to 45%. Erythrocyte filterability (5 μm pore size) was significantly lower, fibrinogen concentration significantly higher, and HDLcholesterol concentration significantly lower in the patient group. No significant differences were found regarding hematocrit, mean corpuscular volume, haemoglobin concentration, leukocyte count and filterability (8 μm pore size), plasma viscosity, and total cholesterol concentration.. The measured hemorheologic abnormalities may contribute to the previously reported reduction of coronary blood flow reserve in DCM patients and to myocardial microcirculatory ...
We tested the effects of submaximal exercise on blood viscosity (ηb), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The ηb was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP, ηb and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in ηb and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease
Authors: Vayá, Amparo , Murado, Julián , Santaolaria, Marisa , Simó, María , Micó, Luisa , Calvo, Javier , Todolí, José , Ricart, Jose M. Article Type: Research Article Abstract: Atherothrombotic events are significant factors of mortality and morbidity in patients with systemic lupus erythematosus (SLE). The extent that rheological factors may be involved in these events in these patients has not been established. We measured the following rheological parameters in 86 patients with SLE, of whom 16 had suffered venous and/or arterial thrombotic events, and in 86 healthy controls: fibrinogen (Fbg), plasma viscosity (PV), blood viscosity at 230 s−1 both at native haematocrit (BVn 230 s−1 ) and corrected to 45% (BVc 230 s−1 ), erythrocyte aggregation at stasis (AE0 ) and at 3 s−1 (AE1 ), …aggregation time (Ta), aggregation index at 10 s (AI10 ), disaggregation threshold (γD), and erythrocyte deformability (ED). In addition glucose, total cholesterol (T-Chol), triglycerides (TG), ...
PubMed journal article Blood viscosity and erythrocyte filterability: their evaluation in diabetes mellitu were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
A patient with Sjögrens syndrome who developed hyperviscosity is described. A polyclonal increase in all immunoglobulins was present, and ultracentrifuge studies showed the presence of intermediate complexes. Very high titers of rheumatoid factors were present. The detailed course of treatment for a 1-year period is presented and correlated with clinical and laboratory variables, such as serum viscosity, protein electrophoresis, levels of gamma globulin, rheumatoid factors, and ultracentrifuge patterns. The remarkable recovery of this patient after a 3-year period is documented. ...
This article discusses the fundamentals for measuring the viscosity of whole blood, serum, and plasma and its application to the diagnosis of hyperviscosity syndrome. We describe some of the terminology in the field, including relevant definitions, t
PubMed journal article Increased blood viscosity in diabetic proliferative retinopath were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
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Multiple Myeloma + Altered Mental Status=Hyperviscosity Syndrome. Although the differential diagnosis of altered mental status is quite extensive, a patient with multiple myeloma and altered mental status should prompt consideration of one important, albeit not too common, condition.....hyperviscosity syndrome.. Some important pearls:. ...
Hyperviscosity Syndrome Presenting as Exercise Induced Pulmonary Hypertension in a Heart Transplant Patient We report an unusual case of exertional dyspnea and exe..
Warnings and Precautions. Severe hypersensitivity reactions may occur with IGIV products, including ASCENIV. In case of hypersensitivity, discontinue ASCENIV infusion immediately and institute appropriate treatment. Patients with known antibodies to IgA may have a greater risk of developing potentially severe hypersensitivity and anaphylactic reactions.. Thrombosis may occur following treatment with immunoglobulin products and in the absence of known risk factors. Consider baseline assessment of blood viscosity in patients at risk for hyperviscosity and ensure adequate hydration before administration. For patients at risk of thrombosis, administer ASCENIV at the minimum dose and infusion rate practicable. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk for hyperviscosity.. Acute renal dysfunction/failure, osmotic nephrosis, and death may occur upon use of human IGIV products. Ensure that patients are not volume depleted before administering ASCENIV. ...
Plasma viscosity estimation is a reflection of changes in plasma proteins within the blood. The values from normal subjects are within a narrowly defined range and change when protein fractions are altered. The major influence on plasma viscosity is exerted by fibrinogen and immunoglobulins. The Viscometer determines viscosity by measuring the resistance of the plasma flow through a capillary under a constant vacuum ...
Evaluation of plasma viscosity has been underutilized in the clinical practice. Plasma viscosity is determined by water-content and macromolecular components. Plasma is a highly concentrated protein solution, therefore weak protein-protein interactions can play a role that is not characterized by el …
BACKGROUND: Hypertension in pregnancy is one of the causes of maternal morbidity and mortality is high in addition to cases of bleeding and infection. In Indonesia hypertension in pregnancy is the cause of 30-40% of perinatal deaths. Hemokonsentrasi state is related to blood viscosity and hematocrit is an important determinant of the blood viscosity. Blood viscosity and peripheral vascular resistance affect the blood flow resistance, which has increased in primary hypertension. Careful observation of the several indicators prediction of preeclampsia, such as hematocrit levels can prevent from unwanted circumstances. METHODS: This research is to design interventions penelitiaan pre test - post to determine the relationship between hematocrit levels in preeclampsia before and after childbirth. All data collected old and new patients were evaluated. Pre and post test data is performed using the t test (t-test) and the test data to find the relationship of hematocrit levels with the degree of ...
This paper describes a procedure, based on Tikhonov regularization, for obtaining the shear rate function or equivalently the viscosity function of blood from Couette viscometry data. For data sets that include points where the sample in the annulus is partially sheared the yield stress of blood will also be obtained. For data sets that do not contain partially sheared points, provided the shear stress is sufficiently low, a different method of estimating the yield stress is proposed. Both the shear rate function and yield stress obtained in this investigation are independent of any rheological model of blood. This procedure is applied to a large set of Couette viscometer data taken from the literature. Results in the form of shear rate and viscosity functions and yield stress are presented for a wide range of hematocrits and are compared against those reported by the originators of the data and against independently measured shear properties of blood.. ...
Cardiovascular risk factors in men, such as cigarette smoking, hypercholesterolemia, and hypertension, also increase risk in women, but the relative susceptibility to risk factors between the sexes is not established. Our aim was to investigate a wide range of possible etiologic factors in a single population study and identify those that were more strongly related to peripheral atherosclerosis in men or women. We studied personal factors (age and social class), lifestyle factors (smoking, exercise, alcohol intake, and dietary nutrients), and intermediary factors (obesity, diabetes, serum lipids, coagulation, and rheological factors). In the Edinburgh Artery Study in 1988 we measured cardiovascular risk factors in a random population sample of 1592 men and women aged 55 to 74 years. The ankle-brachial pressure index (ABPI), which is inversely related to the degree of peripheral atherosclerosis, was assessed in each subject. Lifetime cigarette smoking was correlated with a lower ABPI equally in men and
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The study was carried out to evaluate deformable and aggregative erythrocyte properties in humans under normal and pathological states and in rats exposed to various stressors. A strong correlation between the erythrocyte rheological determinants, i.e. deformability index and aggregation rate, was found under pathological and stress-induced states. The physiological significance of this phenomenon is to maintain the native structure of blood flow.
I understand the other factors affecting BP are blood volume, blood viscosity, resistance, and elasticity of fibres, and those affecting flow are size of blood vessel lumen, blood viscosity, and total blood vessel length ...
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Tropical myeloneuropathies were described initially in tropical countries and are classified into 2 clinical syndromes that can have overlapping features-tropical ataxic neuropathy (TAN) and tropical spastic paraparesis (TSP). TAN and TSP are 2 separate diseases that are grouped together because they both occur predominantly in tropical count...
Semantic Scholar extracted view of Erythrocyte velocity and fluorescein transit time in the cerebral microcirculation of macroglobulinemic mice: differential effect of a hyperviscosity syndrome on the passage of erythrocytes and plasma. by William I . Rosenblum
Question - What are the causes for thick blood? . Ask a Doctor about diagnosis, treatment and medication for Hyperviscosity syndrome, Ask a Hematologist
The Edinburgh Artery Study recruited 1,592 people (809 men and 783 women) ages 55-74 years in 1988 from a general northern European white population sample. Full details of recruitment, data collection at baseline in 1988-1989, methods of follow-up, and definitions of outcomes have been previously described (19,20). The study population was selected to provide a population-based sample by random identification of eligible individuals in 5-year age bands from 11 general practices across the city of Edinburgh that provide primary care for populations of varying socioeconomic status. The response rate was 65%. Respondents were found to be representative of the wider population, as comparisons with a random sample of 20% of nonrespondents did not detect substantial bias (19). Baseline data were collected during participants attendance at a research clinic using a combination of questionnaire and examination data. Complete mortality follow-up was achieved by flagging for deaths at the National ...
Looking for capillary viscometer? Find out information about capillary viscometer. A long, narrow tube that is used to measure the laminar flow of fluids Explanation of capillary viscometer
This video demostration explains how to use the BV1 Single Sample Viscometer and explains the key features that make it perfect for remote sample analysis. The capilliary viscometer can analyze plasma samples stored in EDTA without removing the cap, even if the sample has been previously used for other analyses. The viscometer utilizes only 50-80 µl of plasma per analyses, allowing repeat testing for pediatric and adult samples.
If you have a question about this talk, please contact Ms Helen Gardner.. When red blood cells (RBCs) move through narrow capillaries in the microcirculation, they deform as they flow. In pathophysiological processes such as sickle cell disease and malaria, RBC motion and flow are severely restricted. To understand this threshold of occlusion, we used a combination of experiments and theory to study the motion of a single swollen RBC through a narrow glass capillary of varying inner diameter. By tracking the movement of the squeezed cell as it is driven by a controlled pressure drop, we measured the RBC velocity as a function of the pressure gradient as well as the local capillary diameter, and found that the effective blood viscosity in this regime increases with both decreasing RBC velocity and tube radius by following a power-law that depends upon the length of the confined cell. Our observations are consistent with a simple elasto-hydrodynamic model and highlight the role of lateral ...
Diagnosis Code R70 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Hemodynamic shear forces are intimately linked with cardiac development, during which trabeculae form a network of branching outgrowths from the myocardium. Mutations that alter Notch signaling also result in trabeculation defects. Here, we assessed whether shear stress modulates trabeculation to influence contractile function. Specifically, we acquired 4D (3D + time) images with light sheets by selective plane illumination microscopy (SPIM) for rapid scanning and deep axial penetration during zebrafish morphogenesis. Reduction of blood viscosity via ...
The exact mechanisms responsible for the increased restenosis rate after conventional balloon angioplasty in diabetic patients are unknown. It has been suggested that the prothrombotic milieu present in diabetic coronary vessels, including increased blood viscosity, increased fibrinogen and factor VIII levels, a decrease in the biological activity of antithrombin III, and enhanced platelet aggregation, could play a role in this phenomenon.27 28 29 Previous studies demonstrating that thrombus is both more frequently associated with coronary lesions in diabetic patients30 and is a predictor of late vessel occlusion after angioplasty,15 as well as a study by Rensing et al4 showing that diabetes was a risk factor for late vessel occlusion, are consistent with this hypothesis. Our results demonstrating a fourfold increase in the occlusion rate at follow-up in diabetic patients lend further support to this hypothesis. The analysis of restenosis rates performed after exclusion of the patients with ...
Reduce the serum cholesterol, triglyceride and blood viscosity. It is highly effective for high cholesterol, diabetes, arteriosclerosis and coronary heart disease,preventing the apoplectic seizure and other cardio-cerebral problems ...
1) The light quantum entering into the capillary vessels of the nasal mucosa could reduce the blood viscosity; accelerate the blood the circulation within the nasal tissues. Enhance local blood oxygen saturation, accelerate the absorption and metabolism of nasal tissue to inflammatory substances, eliminate and reduce the nasal obstruction caused by nasal swelling ...
Survival Technology - The need for a healthy diet is emphasized by the four blood viscosity samples in this pack. The samples show the exaggerated differences seen when analyzing blood serum for lipid and glucose concentrations.
Our study is the first to suggest that SCT could worsen the vascular dysfunction among patients with T2DM. In addition, we found elevated blood viscosity and oxidative stress in patients with T2DM-SCT, which, in association with the vascular dysfunction, could increase the risk for vascular disorders in this population.. The principal aim of this study was to test whether the presence of SCT could worsen the vascular dysfunction and the biological abnormalities observed in patients with T2DM. Despite the fact that individuals with T2DM were older than subjects with T2DM-SCT, their vascular function was less altered. PWV, FMD, and corrected FMD were blunted in subjects with T2DM-SCT compared with the three other groups, demonstrating increased arterial stiffness and a loss of vascular reactivity in these subjects, which, in other diseases, have been shown to increase the risks for cardiovascular morbidity and/or mortality (27,28). In agreement with this assumption, a higher number of participants ...
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This study describes how to establish a capillary viscometer (microviscometer) that uses an inline microflowmeter that can accurately measure whole blood e
Designed specifically to keep your costs to a minimum. Send your viscometers to us for cleaning and full UKAS re-calibration. Cleaning and full recalibration in accordance with ASTM D445/ D446 Issue of a UKAS ISO 17025 certificate of calibration Repa
Amalgamation of the space for gas flow around the bobbin to equate to a simple pathway reveals that at the bottom of the flowmeter the resulting dimensions lead to laminar flow but at the top of the tube produce turbulent flow. The physical characteristics of the gas that determine the resulting flow are therefore viscosity at the bottom and density at the top of the tube. The main implication of this is that calibration of rotameters is gas-specific and for accuracy its use must be restricted to that gas. Calibration is usually done to read the flow rate from the top of a bobbin but the centre of a ball.. The range of gas flow measurements can be increased by using two tubes (one for low and one for high flow rates), or by varying the taper so that a greatly increased diameter results at the top of the tube.. Inaccuracy results from anything that causes the bobbin to stick in the tube, including dirt or static electricity. To prevent build-up of static, the inside walls of a rotameter and its ...
The effects of Pluronic F68, a nonionic surface-active agent, on blood viscosity and platelet adhesiveness during extracorporeal circulation were investigated. Blood viscosity was significantly decreased. Platelet adhesiveness decreased markedly in six patients within ten minutes after intravenous injection. Pluronic F68 has many properties and actions which make it a useful additive to perfusion systems. Its potential in the treatment of diseases in which high viscosity or increased platelet adhesiveness are present deserves investigation.. ...