EL-KARIB, Abbas O et al. Pre-Diabetes Induces Ultrastructural Alterations in the Large Blood Vessel Aorta in Rats. Int. J. Morphol. [online]. 2019, vol.37, n.2, pp.647-653. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022019000200647.. Excessive consumption of carbohydrate and fat increases the risk of cardiovascular disease. We sought to determine the potential ultrastructural alterations in large blood vessels induced by a high fat and fructose diet (HFD) in a rat model of prediabetes. Rats were either fed with HFD (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. The harvested thoracic aorta tissues were examined using transmission electron microscopy (TEM), and blood samples were assayed for biomarkers of pre-diabetes.TEM images showed that HFD induced profound pathological changes to the aortic wall layers, tunica intima and tunica media ultrastructures in the pre-diabetic rats as shown by apoptotic endothelial cells with pyknotic nuclei, ...
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We have utilized the zebrafish to study arterial and venous differentiation during embryonic blood vessel formation. As in mouse and Xenopus, we find molecular differences between arteries and veins can be demonstrated before circulation in zebrafish embryos by the expression of the transmembrane ligand EphrinB2 and the EphB4 homolog rtk5 (Cooke et al., 1997), respectively. We find that notch3 is also expressed specifically within the vasculature in the DA beginning at the 18-somite stage, similar to the temporal expression pattern of ephrinB2. This artery-restricted pattern of expression and the known role of Notch signaling in cell fate decisions led us to investigate the role of this pathway during arterio-venous differentiation.. We determined the effect on vascular development of both loss and gain of Notch activity during embryonic development. We are able to effectively inhibit the Notch pathway using a dominant negative form of Su(H) that fails to bind DNA (Wettstein et al., 1997). In ...
In this study we describe a model system that allows continuous in vivo observation of the vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis. We demonstrate …
Abstract: A brief overview of mathematical models of contemporary applied hemodynamics is given. The special attention is paid to questions of development of effective computational algorithms implementing one-dimensional model. For this purpose TVD-monotonized schemes having the second order accuracy both in time and space are used. A number of test problems with analytical solutions are proposed. Questions of convergence and a choice of grid parameters for various schemes are investigated. The approaches using multiscale hemodynamics models are considered. An embedding of one-dimensional model of a single vessel into 0-dimensional model of vascular system is implemented. The possibility of using linear model for considered class problems of hemodynamics is analyzed ...
The radius of the pulmonary arteries and of the descending thoracic aorta in man was measured by angiographic techniques. Simultaneously with angiocardiography, pressure measurements were carried out, permitting calculation of radius-pressure (ΔR/ΔP) relationships. The results obtained by this method are similar to those obtained by other methods in which the vessel radius was measured more directly.. ...
To understand what happens when the heart stops, it is first important to understand the function of the heart. After all, when the heart stops its function ceases. The heart is a hollow organ that is made up of four chambers - right atrium, right ventricle, left atrium and left ventricle. Large blood vessels lead to and away from these chambers. Valves control blood flow between chambers and between the chambers and the large blood vessels.. The heart is a pump that receives low oxygen blood from the rest of the body (in the right atrium) and pushes this blood to the lungs (from the right ventricle). The blood is then oxygenated by the lungs and carbon dioxide is expelled. Then the blood returns to the heart (in the left atrium). From here, the oxygen-rich blood is pumped to the rest of the body (from the left ventricle). Therefore the heart is responsible for ensuring that there is sufficient oxygen available for all the cells in the body but blood also carries nutrients and other essential ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Angiogenesis is an essential process whereby new blood vessels are formed from pre-existing vessels and occurs under both normal and pathophysiological conditions. growth element receptor 1 (sVEGFR-1). Therefore, FoxC1 appears to control angiogenesis by regulating two unique and opposing mechanisms; if so, vascular development could be identified, at least in part, Elvitegravir by a competitive balance between pro-angiogenic and anti-angiogenic FoxC1-controlled pathways. With this review, we describe the mechanisms by which FoxC1 regulates vessel growth and discuss how these observations could contribute to a more total understanding of the part of FoxC1 in pathological angiogenesis. Intro Under both physiological and pathological conditions, new blood vessels are created from pre-existing vessels through a process called angiogenesis, which is definitely exactly controlled by the balance between pro-angiogenic and anti-angiogenic factors. Vascular endothelial growth element (VEGF)-A is perhaps ...
Small Blood Vessel Problems: when your blood sugars stay too high for a long time, your small blood vessels may be harmed. This can cause problems with your eyes and kidneys. It can also cause problems with blood circulation to your feet and skin. High levels of sugar in your blood make it harder for the red blood cells to squeeze into very small blood vessels in your body. Sugar also makes the walls of your blood vessels less strong. When the red blood cells try to squeeze into the small blood vessels, they damage the vessels even more. This can make your blood vessels so weak they burst. If this happens, your eyes may be harmed and further problems, if not detected or treated, can lead to blindness (Diabetic Retinopathy). Your kidneys may also be damaged (Diabetic Nephropathy) and, if not looked after, may end up not working at all ...
Peripheral artery disease (PAD) is a complex, often underdiagnosed illness with rising prevalence in western world countries. During the past decade there has been a rapid advance especially in the field of endovascular treatment of PAD. Here we present for the first time a case reporting on the placement of coronary stent graft in a peripheral vessel for the management of a peripheral side branch perforation. Interventional angiologists or radiologists may consider such an option for complication management after injury of smaller vessels during peripheral percutaneous interventions. Further specialization and novel options of complication management as described in our case may shift the treatment from surgical to even more endovascular treatment procedures in the future.
The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. [GOC:dsf, PMID:16740480]
Diabetes mellitus significantly increases the risk for both small and large blood vessel complications e.g. diabetic eye problems and coronary heart disease. Vital organs such as the eye, kidney, heart and brain represent well− recognized preferential targets in patients with diabetes mellitus. The presence of such end−organ damage powerfully influences cardiovascular risk and the benefits of therapeutic interventions. Unfortunately, by the time symptoms develop or events occur as manifestations of target−organ damage, the disease process is already at an advanced stage. Although not traditionally viewed as an end−organ, it is altered structure and function of arterial small blood vessels that acts as the substrate for accelerated disease development and the increased occurrence of vascular events in patients with diabetes mellitus. The ability to detect and monitor sub−clinical damage, representing the cumulative and integrated influence of all risk factors in impairing arterial wall ...
High and low blood sugars can cause a variety of complications in the short term or the long-term. The primary cause of complications is that higher levels of blood sugar cause your blood to become more acidic. Over time, this causes a variety of complications related to your small blood vessels (microvascular) and your large blood vessels (macrovascular). The major long-term studies of diabetes, particularly the DCCT and EDIC, have found that people with diabetes who can keep their HbA1c below 7% experience significantly fewer complications. Most importantly, even a few years of better blood sugars can pay off with fewer complications even decades later. Increasingly, studies are using continuous glucose meters to measure not just average blood sugars, but also how often you spend in the normal range. There is some evidence and many suspect that time spent in this range may be more important than your HbA1c in
Macrovascular disease is related with large blood vessels like arteries, coronary and the sizable arteries in the brain and in the limbs. Diabetes and hyperglycemia are causes of development of microvascular disease. Mostly type 2 diabetes increases the risk of microvascular disease of kidneys, eyes and nerves. Microvascular disease can result into kidney failure, blindness, impotence (in men) and foot ulcers. Usually microvascular complications occur due to high level of sugar over time that is it happens after many years of diabetes.. Macrovascular complications of diabetes directly affect on the blood vessels. Because of high diabetes linings of the blood vessels get damaged and become narrow, as a result of this the blood supply decreases in the affected area. When blood vessels of the brain and heart get affected it results in heart attack or stroke. Problems of blood circulation, decreased sensation, and leg cramps happen due to affected blood vessels in the legs. For diabetes treatment ...
Diabetic macrovascular complications result from changes in the medium to large blood vessels. Blood vessel walls thicken, sclerose, and become occluded by plaque that adheres to the vessel walls. Eventually, blood flow is blocked. These atherosclerotic changes are indistinguishable from atherosclerotic changes in people without diabetes, but they tend to occur more often and at an earlier age in diabetes. Coronary artery disease, cerebrovascular disease, and peripheral vascular disease are the three main types of macrovascular complications that occur more frequently in the diabetic population. Myocardial infarction is twice as common in diabetic men and three times as common in diabetic women. There is also an increased risk for complications resulting from myocardial infarction and an increased likelihood of a second myocardial infarction. Coronary artery disease may account for 50% to 60% of all deaths in patients with diabetes. One unique feature of coronary artery disease in patients with ...
The purpose of this study is to determine if women with chest pain and clean heart blood vessels have impaired blood flow to the heart due to problems with the small blood vessels that provide blood and oxygen to the heart. Impairment in the small blood vessels will be tested using ultrasound pictures of the heart, called myocardial contrast echocardiography. Since these small blood vessels are not seen in a coronary angiogram, which is an x-ray of the heart vessels using a dye containing iodine injected in the heart vessels, the problem may remain undiagnosed in women until the heart muscle becomes severely damaged.. A second purpose is to identify if there is a common trait in the population of women with this tiny blood vessel dysfunction, which will be investigated by checking blood levels of certain chemical and hormones related to heart disease. Finally, we would like to investigate the relationship between depression and stress, and heart disease. We will do this by measuring cortisol ...
Find liposuctioned fat cells turned into small blood vessels. Mississsippi Stem Cell Therapy Center promotes stem cell therapy and regenerative medicine.
Dear Penny Pritzker, Secretary of Commerce:. We urge you to intervene and to stop all orca experiments that involve satellite tagging and skin biopsies. Both of these barbaric methods can cause infections and deaths.. The death of orca L95 in March 2016 led the US responsible parties to halt all barbaric satellite tags pending a review. The tags are actually sharp barb-like blades that penetrate the skin. On October 4th a press conference was held by NOAA Fisheries. At that meeting the following information was given:. 1. The death of orca L95 was due to a fungal infection. The first dart attempt failed and due to human error it was not properly sterilized as per protocol. It was also done in waters that were known to have this fungus. The dart was shot into the area of the dorsal fin where large blood vessels are located.. 2. Unlike Canada that is not using satellite tags since it is deemed too invasive and alternatives are available, NOAA will only suspend the experiments on the endangered ...
There is a growing body of evidence on the importance of hemodynamic forces (i.e. blood flow and pressure) in regulating endothelial cell behavior and blood vessel formation. I was part of a recent discovery published in Nature Cell Biology that identified a new type of membrane protrusion-called inverse blebbing-at the apical membrane of endothelial cells. These inverse blebs drive the expansion of the lumen, which is a structure that allows blood to flow through the vessels. This process is therefore important in the formation of functional blood vessels ...
Aortobifemoral bypass surgery is used to bypass a narrowed or blocked part of the large blood vessels in the abdomen and groin. To bypass the diseased part of the blood vessel, blood is redirected through a graft. The graft is made of man-made material. This graft is sewn above and below the diseased vessel so that...
The most common symptom of internal hemroids is bright red bleeding on underwear, toilet paper, stool or in toilet water.. Internal hemroids are incredibly prone to easy bleeding for a number of reasons. The first reason is that an internal hemroid is a protrusion into the anal canal, which is supposed to be rather smooth. Of course, any protrusion is going to get hit more than smooth muscle wall.. In addition, the mucus membrane is thinner and more delicate than skin to begin with. When it swells outwards, as with a hemroid, the overlying tissue gets even thinner.. Most internal hemroids are also inflamed to some degree, which means that there is more blood collecting in the hemroid than in other areas of the anal canal, which means that more blood comes out.. Last, an internal hemroid is a varicosity, or swelling, of a relatively large blood vessel. Therefore a hemroid brings its blood vessel much closer to the surface of the mucus membrane than normal, which vastly increases the chance of ...
Biological Process: artery morphogenesis; atrial cardiac muscle morphogenesis; BMP signaling pathway; branching involved in blood vessel morphogenesis; cell adhesion; central nervous system vasculogenesis; chronological cell aging; heart looping; negative regulation of cell migration; negative regulation of protein autophosphorylation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of collagen biosynthetic process; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; response to corticosteroid stimulus; response to drug; smooth muscle development; sprouting angiogenesis; vasculogenesis; venous blood vessel morphogenesis ...
g. Go to the energency department)- the next cough could break a large blood vessel. Otherwise, blood-tinged sputum can occur with forceful coughing with some smaller blood vessels breaking. In the latter scenario, as long as a person can breath fine, then schedue a visit with your doctor. Would you like to video or text chat with me? ...
For the study, researchers used lasers to create a clean split with two broken ends in the small blood vessels of the zebrafish brain. Then, through a specialized microscope, they observed what happened after the blood vessels were ruptured. The researchers noticed an unexpected repair process that started about a half hour after they induced the vessel damage. A macrophage showed up, and extended two arms from its body toward the ends of a broken blood vessel, using a variety of adhesion molecules to attach itself to the vessel. Then, it pulled the two broken ends together to mediate their repair. The macrophage left the scene after the blood vessel was repaired. The whole process took about three hours.. In addition, the researchers noted that usually only one macrophage arrived at the laser-wound site to mend the broken ends. Rarely, two macrophages arrived at the injury on their own-in these instances, each macrophage grabbed one of the broken ends of the blood vessel. However, the ...
While BOLD contrast reflects hemodynamic changes within capillaries serving neural tissue, it also has a venous component. Studies that have determined the relation of large blood vessels to the activation map indicate that veins are the source of the largest response, and the most delayed in time. It would be informative if the location of these large veins could be extracted from the properties of the functional responses, since vessels are not visible in BOLD contrast images. The present study describes a method for investigating whether measures taken from the functional response can reliably predict vein location, or at least be useful in down-weighting the venous contribution to the activation response, and illustrates this method using data from one subject. We combined fMRI at 3 Tesla with high-resolution anatomic imaging and MR venography to test whether the intrinsic properties of activation time courses corresponded to tissue type. Measures were taken from a gamma fit to the functional
The chemokine CXCL12/SDF1a has first been described in the immune system where it functions include chemotaxis for lymphocytes and macrophages, migration of hematopoietic cells from fetal liver to bone marrow and the formation of large blood vessels. Among other chemokines, CXCL12 has recently attracted much attention in the brain as it has been shown that it can be produced not only by glial cells but also by neurons. In addition, its receptors CXCR4 and CXCR7, which are belonging to the G-protein coupled receptors family, are abundantly expressed in diverse brain area, CXCR4 being a major co-receptor for human immunodeficiency virus (HIV)-1 entry. This chemokine system has been shown to play important roles in brain plasticity processes occurring during development but also in the physiology of the brain in normal and pathological conditions. For example, in neurons, CXCR4 stimulation has been shown regulate the synaptic release of glutamate and GABA. It can also act post-synaptically by activating a
An abdominal aortic aneurysm (AAA) is described by doctors as a pathological dilation of the main abdominal artery (aorta). Its diameter varies depending on age and sex; an abdominal aorta with a diameter of 3 cm or more is called an AAA. The risk increases with age, whereby women are markedly less often affected than men.Most AAAs cause no problems, that is, they are asymptomatic. However, the larger the size of the AAA, the greater the danger that this large blood vessel will rupture. Without treatment such a rupture quickly results in death. But even if patients reach a hospital on time and emergency surgery is still possible, about 40% of patients receiving open surgery and about 20% receiving endovascular surgery die.Screening aims to lower risk of death. In contrast, if an AAA is detected in time and a patient can undergo elective surgery, the chance of survival is considerably higher: Depending on the type of surgery (endovascular or open) in Germany between 1.3% and 3.6% of patients die ...
Abdominal ultrasound is often used to check large blood vessel known as the abdominal aorta that passes from the back of the chest and abdomen. Learn on facts, procedure & more.
The heart has four chambers. Each chamber fills with blood and empties the blood into another chamber or a large blood vessel. Each of the four chambers has a heart valve which opens and closes when the blood fills or is expelled from the chamber. Unfortunately, either by an accident of birth or certain disease and degenerative conditions, the leaflets of these valves can be damaged, malformed or scarred leading to inability of the valve to open (stenosis) or to close correctly,(insufficiency or regurgitation, the leaky valve).. ...
When the child fever does not make calm. Children become fussy and a little inconvenient. Fever also makes the child difficult to sleep, because they feel uncomfortable. There are many causes of fever such as flu, immunization, and teething. There are many ways to reduce fever, one of them by way of compressing. If mom during this time to compress the child with cold water should immediately stop this habit. Compressing the right child is with warm water. Warm water effectively lower body temperature in children. By compressing warm water, then the center of body temperature will receive information that she around the body is warm. Then the body will automatically lower its temperature.. Compressing the right is in the folds of the body rather than on the forehead. So put the compress on the armpit and groin. This is because the body folds are bypassed by large blood vessels, which function to inform the brain to lower the bodys sushi. So the fever was gone. After the compress, dry the wet ...
The procedure of egg collection is practically painless as it is done under intravenous analgesia (sedation) administered by the anaesthetist. Another reason why the egg collection should be done under sedation is to avoid any involuntary movement by the patient that could momentarily move the egg collection needle and cause damage to the ovary or other structures close to the ovary (uterus, intestine, a large blood vessel etc.). An egg collection is usually a quick procedure, lasting about 10-30 minutes, depending on the number of the follicles, the degree of difficulty of the aspiration etc. The patient usually needs to stay in the recovery room for a further 30 minutes to 1 hour to rest and allow the staff to ensure that they are well enough to leave the Unit.. Before leaving the Unit, the patient is informed about the number of the eggs retrieved and will receive further instructions for the continuation of the treatment.. ...
|br/|Three-dimensional visualizations of cerebral vessel structures are helpful for diagnosing diseases. However, when viewing several overlapping cerebral
For validation, we first use synthetically generated airways and vessels produced by the proposed generative model to compute the relative error and directly evaluate the accuracy of CNR in comparison with traditional methods. Then, in-vivo validation is performed by analyzing the association between the percentage of the predicted forced expiratory volume in one second (FEV1\%) and the value of the Pi10 parameter, two well-known measures of lung function and airway disease, for airways. For vessels, we assess the correlation between our estimate of the small-vessel blood volume and the lungs diffusing capacity for carbon monoxide (DLCO ...
During the development of the vascular network, blood vessels are constantly formed but many of them are only required temporarily. Just like a disused arm of a highly branched river, the flow of fresh blood through these vessels is interrupted and the organism begins to prune this side arm. In this way the vascular system regulates itself, optimizing its blood circulation by pruning and recycling the unnecessary vessels with reduced blood flow and blood pressure.. This newly uncovered process is important for the understanding of blood vessel formation and regression on the cellular level, as this can also explain the extraordinary plasticity and changeability of the vascular system, says Anna Lenard, the first author of this publication. These investigations were performed on the zebrafish, as in this almost transparent fish the development of blood vessels can be observed in the living animal using modern microscopy techniques.. Relevance of self-fusion for cancer?. How the cell recognizes ...
blood vessel a vessel in which blood circulates The blood vessels are the part of the circulatory system that transport blood throughout the body. There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the…
On September 19, 2017, Posted by Birgit Rogell , In Press Releases, With Kommentare deaktiviert für Heidelberg University: How Blood Vessels Are Formed ...
Blood vessels. Coloured scanning electron micrograph (SEM) of a resin cast of blood vessels in a lymph node. The fine network of smaller vessels branching off from the main vessel infiltrates the tissue, supplying it with blood. Gases and nutrients are exchanged between the blood and surrounding tissues through the permeable walls of capillaries, the smallest blood vessels. Connective tissues provide structural support and cohesion throughout the body. The cast was made by injecting resin into the blood vessels, followed by chemical digestion of the surrounding tissues. Magnification: x36 at 6x7cm size. - Stock Image P206/0248
In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers have targeted a sugar that supports blood vessel growth in the tumor.
The skin is highly vascularized meaning that it has an extensive network of blood vessels just under the outer layer of the skin. Apart from nourishing the skin with oxygen and nutrients, and removing wastes and carbon dioxide, blood vessels also play a role in thermoregulation. Here it can widen (dilate) to allow heat within the body to pass out into the body thereby preventing the internal temperature from rising to dangerous levels. Conversely, when the environment is cold or the internal temperature is lower than normal, these blood vessels become narrow (constrict) thereby reducing the blood flow to the skin. Therefore less heat from within the body is lost to the environment.. Arteries carry oxygen rich blood from the heart to the skin and veins take away blood laden with wastes and carbon dioxide away from the skin. However, these blood vessels are large and slowly become smaller to be able to lie closely to the skin tissue. Arteries become smaller arterioles and eventually blood from ...
T-cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8+ T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major endothelial cell-specific junctional protein that controls vascular integrity. A decrease in VE-cadherin expression is associated with tumor pathology. We developed an oligonucleotide-based inhibitor (CD5-2), which disrupted the interaction of VE-cadherin with its regulator miR-27a, resulting in increased VE-cadherin expression. Administration of CD5-2 in tumor-bearing mice enhanced expression of VE-cadherin in tumor endothelium, activating TIE-2 and tight junction pathways and normalizing vessel structure and function. CD5-2 administration also enhanced tumor-specific T-cell infiltration and spatially redistributed CD8+ T cells within the tumor parenchyma. Finally, CD5-2 treatment ...
With intracoronary IVUS, a catheter is inserted into a coronary artery where high-frequency sound waves reflect off tissue or vessel walls. The reflected sound waves create a cross-sectional image from within the vessel to aid in visualising vessel structure. IVUS technology provides physicians with a better understanding of atherosclerotic vessels, supporting appropriate treatment strategy, stent selection, stent placement and adequate deployment to restore blood flow at the target site ...
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. [GOC:hjd, UBERON:0001981]
Arti kata dari arterial blood vessel. Definisi dari arterial blood vessel. Pengertian dari arterial blood vessel: a blood vessel that carries blood from the heart to the body;
1. Cell - structure, function of organelles, cell division. Tissues: epithelial, connective, muscle and nerve. 2. Skeletal system - the shape, surface, internal structure, growth and development, bone connections. skeleton of the torso (spine, chest), skull bone, upper and lower extremities skeleton. 3. Muscular system - structure, composition and properties of skeletal muscles. Description of major muscle groups. 4. Blood - quantity, composition and functions of blood. The heart - shape, structure and activity. Blood vessels - structure (arteries, capillaries, veins). The heart - greater and lesser blood circulation. 5. Lymphatic system. 6. Respiratory system - external and internal respiration, nose, nasal cavity, larynx, trachea, lungs. 7. Digestive system - oral cavity, pharynx, esophagus, stomach, small intestine, large intestine, pancreas, liver. 8. Excretory system - kidneys, urinary tract. 9. Cutaneous system - skin structure, additional skin formations, body temperature and its control. ...
1. Cell - structure, function of organelles, cell division. Tissues: epithelial, connective, muscle and nerve. 2. Skeletal system - the shape, surface, internal structure, growth and development, bone connections. skeleton of the torso (spine, chest), skull bone, upper and lower extremities skeleton. 3. Muscular system - structure, composition and properties of skeletal muscles. Description of major muscle groups. 4. Blood - quantity, composition and functions of blood. The heart - shape, structure and activity. Blood vessels - structure (arteries, capillaries, veins). The heart - greater and lesser blood circulation. 5. Lymphatic system. 6. Respiratory system - external and internal respiration, nose, nasal cavity, larynx, trachea, lungs. 7. Digestive system - oral cavity, pharynx, esophagus, stomach, small intestine, large intestine, pancreas, liver. 8. Excretory system - kidneys, urinary tract. 9. Cutaneous system - skin structure, additional skin formations, body temperature and its control. ...
Scientists estimate that over 70 percent of human deaths worldwide are ultimately caused by damaged or failing blood vessels. Stroke and myocardial infarction are the leading causes of death as a consequence of hypertension, atherosclerotic deposits in the vessel walls or of blood clotting problems. Even cancer or the devastating late effects of diabetes are also closely linked to regulatory defects or damage in the vascular system. The network of scientists in the Collaborative Research Centre (SFB) Transregio 23 is in its 12th year of studying the influences that regulate the cells of the vessel wall. It is undisputed by now that the blood vessels are much more than tubes for the blood and that the function of the vessel wall reaches far beyond that of a mere passive barrier, says SFB coordinator Hellmut Augustin from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim of Heidelberg University. We know now that vessels dynamically control their environment, thereby ...
: : My father just had a serious stroke. A doppler test found a blood clot behind the heart measuring some 6 inches from which the clot that caused the stroke must likely broke off from. The surgery ...
Having clots in periods doesnt necessarily indicate a disease and isnt necessarily normal. It has to be judged upon correct parameter by a doctor. However, knowledge is the key for better health and living.
Scientists have managed to grow perfect human blood vessels as organoids in a petri dish for the first time. The breakthrough engineering technology, outlined in a new study published today in Nature, dramatically advances research of vascular diseases like diabetes, identifying a key pathway to potentially prevent changes to blood vessels--a major cause of death and morbidity among those with diabetes.