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Bisoprolol in patients with heart failure and moderate to severe chronic obstructive pulmonary disease: a randomized controlled trial.

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Hello John,. I tried Digoxin together with Flecainide for AF a few years ago. I didnt like it at all and it seemed to make my AF and heart rate even worse. The heart rate went exceedingly high at times. My EP thought it would hold down my heart rates without dropping my blood pressure too much as might a beta blocker. Digoxin is I believe an old med and quite a heavy weight one and levels of the drug can build in the blood stream causing toxicity if periodic checks of Digoxin levels are not carried out. I had to have frequent checks of my Digoxin levels due to poor kidney clearance.. I am now however on Bisoprolol a beta blocker, low dose, which is preventing my heart rates from going so high. It has proved most effective. My EP felt it was a safer option for me because Bisoprolol is a cardio selective beta blocker (targets mainly heart tissue) whereas some beta blockers will target tissue outside of the heart too, for example the lungs, which would not be helpful for those suffering from lung ...

A randomized, placebo-controlled, double-blind crossover investigation in 12 patients with non-asthmatic chronic obstructive lung disease and co-existing stable angina pectoris was done to compare...

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Dear DoctorMy husband is 64 years old and was diagnosed with Chronic Kidney Disease (CKD) about 2-3 years ago. He lost one kidney due to a rugby injury many years ago. He has had a lot of downward swings in his GFR this year for various reasons but the average has been about 27. It is currently on 30. His BP is difficult to control. At the moment he is averaging about 158/87. He is on four medications (2 x 8mg Cardura XL (Doxazosin - Alpha Blocker), 1 x Zanidip 20mg (Lercanidipine Hydrochloride - Calcium Channel Blocker) 1 x Bilocor 10mg (Bisoprolol Fumarate - Beta Blocker) and 1 x Physiotens 0.4mgs (Moxonodine - Central Acting Hypertensive) and has just had a diuretic added (Daptril 2.5mg (Indapamide). He was previously on a potassium sparing diuretic (Spiractalone) and Ramipril and his Potassium went up to 7.8 and so these medications were withdrawn. My question is, he has, for at least the last year, been very breathless after hardly any activity i.e. after having a shower. He has now started ...

Studies reviewed that provide primary data regarding the efficacy and safety of beta-blocker therapy in noncardiac surgery are summarized in Appendix 3. A more detailed discussion of these studies and of systematic reviews and meta-analyses incorporating these data is provided in the sections that follow. Several randomized trials examined the effect of perioperative beta blockers on cardiac events surrounding surgery. Poldermans et al5 examined the effect of bisoprolol on patients undergoing vascular surgery and in patients at high risk for perioperative cardiac complications who were scheduled for vascular surgery. Of 846 patients with risk factors for cardiac disease, 173 were found to have new regional wall-motion abnormalities with stress on dobutamine stress echocardiography. Of these patients, 61 were excluded from further study owing to large areas (5 or more segments) of regional wall-motion abnormalities on dobutamine stress echocardiography or because they were already taking beta ...

in Annals of Thoracic Surgery (2006), 81(3), 958-66. BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ... [more ▼]. BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ventricular septal defect in infancy was different compared with normal children and influenced by the preoperative condition of hypoxemia or cardiac insufficiency. METHODS: Forty unselected children, 20 with tetralogy of Fallot and hypoxemia and 20 with ventricular septal defect and cardiac insufficiency, operated on with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass at a mean age of 0.7 +/- 0.3 years (mean +/- SD), underwent, at mean age 7.4 +/- 1.6 years, standardized evaluation of neurologic status, ...

in Annals of Thoracic Surgery (2006), 81(3), 958-66. BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ... [more ▼]. BACKGROUND: The purpose of this prospective study was to assess whether neurodevelopmental status and exercise capacity of children 5 to 10 years after corrective surgery for tetralogy of Fallot or ventricular septal defect in infancy was different compared with normal children and influenced by the preoperative condition of hypoxemia or cardiac insufficiency. METHODS: Forty unselected children, 20 with tetralogy of Fallot and hypoxemia and 20 with ventricular septal defect and cardiac insufficiency, operated on with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass at a mean age of 0.7 +/- 0.3 years (mean +/- SD), underwent, at mean age 7.4 +/- 1.6 years, standardized evaluation of neurologic status, ...

Comment: Histologic changes are consistent with left- and right-sided cardiac insufficiency. Histiologic changes were particularly severe in the right ventricle, although I suspect there were left ventricle lesions that were also present but not represented in the sections based on the changes in the lung. Cardiac insufficiency also accounts for the effusions noted in the abdominal cavity and thoracic cavity. This animal also had advanced nephrosclerosis, particularly for its age. I suspect that previous episodes of hypoxia and infraction contributed significantly to these degenerative disease processes. The changes are not characteristic of congenital renal dysplasia or primary infectious process in the kidney. The renal insufficiency may also have contributed to the effusions. An interesting feature in this case is the parasite migration in one of the lymph nodes. This is a rare lesion for a cavy. Parasites are degenerative and could not be positively identified, although they most closely ...

Background: Beta-blockers are widely used for rate control in atrial fibrillation (AF). On the other hand, there is evidence that oxidative stress and inflammation contribute to the pathophysiology of AF. Effects of beta-blockers on atrial remodeling and its underling mechanisms are yet elucidated. Thus, we evaluated the effects of comparable beta-blockers, carvedilol (CAR), known to have antioxidant and anti-inflammatory properties beyond its beta-blocking action, and a selective beta-blocker, bisoprolol (BISO).. Methods: Dogs underwent atrial tachypacing (ATP) at 400 bpm for 2 weeks to induce atrial remodeling and divided into 4 groups; non-paced controls (NP, n=8), ATP-only (n=8), and ATP with either CAR (50 mg/day, n=6) or BISO (12.5 mg/day, n=3), begun 3 days prior to ATP onset. Serial EP studies were performed at baseline, 1- and 2-week of ATP. We also measured the value of serum derivatives of reactive oxidative metabolites (DROMs) as an oxidative stress marker and CRP levels at the end ...

Metoprolol (Lopresor®);Bisoprolol (Monocor®); Carvedilol (Coreg®); Atenolol (Tenormin®); Acebutolol (Sectral®, Monitan®); Propranolol (Inderal®) What are beta-blockers used for? • To prevent chest pain (angina) • To treat high blood pressure • To treat heart failure • To prevent irregular heart rhythms (arrhythmias) • To prevent heart attacks • To treat some symptoms of anxiety In patients with irregular heart rhythms, beta blockers are used as rate control agents, which prevent the heart from beating too fast. Although beta blockers do not make the heart beat at a regular pace, they may help reduce symptoms patients experience with irregular heartbeats. In heart failure, beta-blockers are used to strengthen the heart muscle and help the heart pump more effectively. Why should I take this medication? How do beta-blockers work? What should I expect? How do I take beta-blockers? What should I watch for? (English) Colour ...

The percentage of patients 18 years of age and older during the measurement year who were hospitalized and discharged from July 1 of the year prior to the measurement year to June 30 of the measurement year with a diagnosis of acute myocardial infarction (AMI) and who were prescribed persistent beta-blocker treatment for six months after discharge

Do β-blockers improve morbidity and mortality in patients with heart failure? 3 large trials have shown the benefits of bisoprolol (1), carvedilol (2), and metoprolol (3) on morbidity and mortality among patients with NYHA class II or III heart failure and have had important implications for how patients with mild-to-moderate heart failure are treated. On the basis of these studies, it has now become standard practice to treat such patients with one of these β-blockers. Whether patients with severe heart failure would also benefit from β-blockade has been unanswered. Patients with severe heart failure have the highest sympathetic outflow and theoretically may benefit most from β-blockade. These patients also have the least inotropic reserve and thus are most susceptible to decompensation when treated with β-blockade. These 2 studies (BEST and COPERNICUS) have provided important data that allow us to assess the benefit of β-blockers in patients with severe heart failure. What is certain is ...

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In this article, we will discuss the NYHA (New York Heart Association) functional classification of Heart Failure. So, lets get started.. Classification. Class I (Asymptomatic): No limitation on physical activity. Ordinary physical activity does not cause symptoms of Heart Failure (Patient with cardiac disease but no symptoms).. Class II (Symptomatic with moderate activity): Patients with cardiac disease are comfortable at rest and after mild activity, but moderate activity results in dyspnea, palpitation, and fatigue.. Class III (Symptomatic with mild activity): Patients with cardiac disease have marked limitation of physical activity. Comfortable at rest, but less than normal activity results in fatigue, dyspnea, and palpitation.. Class IV (Symptomatic at rest): Patients have symptoms of cardiac insufficiency at rest, and any physical activity further increases the discomfort. They are unable to carry out any physical activity without discomfort.. ...

Background. Sex differences in LV mechanics exist at rest and during acute physiological stress. Differences in cardiac autonomic and adrenergic control may contribute to sex differences in LV mechanics and LV hemodynamics. Accordingly, this study aimed to investigate sex differences in LV mechanics with altered adrenergic stimulation achieved through post handgrip exercise ischemia (PEI) and ß1-adrenergic receptor (AR) blockade. Methods and Results. 20 males (23±5 yr) and 20 females (22±3 yr) were specifically matched for LV length (males: 8.5±0.5 cm, females: 8.2±0.6 cm, p=0.163), and 2-dimensional speckle-tracking echocardiography was used to assess LV structure and function at baseline, during PEI and following administration of 5mg bisoprolol (ß1-AR antagonist). During PEI, LV end-diastolic volume and stroke volume were increased in both groups (p,0.001), as was end-systolic wall stress (p,0.001). LV twist and apical rotation werent altered from baseline or different between the ...

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Cardiovascular research belongs to the most rapidly growing biomedical disciplines as it deals predominantly with diseases that are the leading cause of death in industrial countries. These include, but are not limited to coronary heart disease, cardiomyopathy, hypertension and arterial disease, heart hypertrophy, heart failure, arteriosclerosis, stroke, peripheral arterial disease and varicosis. The focus of my group is on the investigation of biomechanically triggered mechanisms which either promote cardiovascular diseases or at least partially compensate their harmful effects. Therefore, we are especially interested in the analysis of cardiac insufficiency, development of arteriosclerotic lesions, hypertension-induced arterial remodeling, varicose vein formation as well as arteriogenesis, the formation of collateral arteries from preexisting arterioles to compensate the occlusion of a conduit artery. All of these pathophysiological processes are basically associated with the adaptive or ...

Furosemide is a diuretic used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. Promotes the rapid removal of abnormally retained extracellular fluids.

To analyze the impact of multimorbidity (MM) on health care costs taking into account data heterogeneity. Data come from a multicenter prospective cohort study of 1,050 randomly selected primary care patients aged 65 to 85 years suffering from MM in Germany. MM was defined as co-occurrence of ≥3 conditions from a list of 29 chronic diseases. A conditional inference tree (CTREE) algorithm was used to detect the underlying structure and most influential variables on costs of inpatient care, outpatient care, medications as well as formal and informal nursing care. Irrespective of the number and combination of co-morbidities, a limited number of factors influential on costs were detected. Parkinsons disease (PD) and cardiac insufficiency (CI) were the most influential variables for total costs. Compared to patients not suffering from any of the two conditions, PD increases predicted mean total costs 3.5-fold to approximately € 11,000 per 6 months, and CI two-fold to approximately € 6,100. The high

To analyze the impact of multimorbidity (MM) on health care costs taking into account data heterogeneity. Data come from a multicenter prospective cohort study of 1,050 randomly selected primary care patients aged 65 to 85 years suffering from MM in Germany. MM was defined as co-occurrence of ≥3 conditions from a list of 29 chronic diseases. A conditional inference tree (CTREE) algorithm was used to detect the underlying structure and most influential variables on costs of inpatient care, outpatient care, medications as well as formal and informal nursing care. Irrespective of the number and combination of co-morbidities, a limited number of factors influential on costs were detected. Parkinsons disease (PD) and cardiac insufficiency (CI) were the most influential variables for total costs. Compared to patients not suffering from any of the two conditions, PD increases predicted mean total costs 3.5-fold to approximately € 11,000 per 6 months, and CI two-fold to approximately € 6,100. The high

Care is provided for patients with the complete range of congenital heart defects which have been surgically or catheter-interventionally corrected, partially corrected or have not been corrected. Special attention is given to the timely planning of initial procedures or repeated procedures (operations or catheter intervention) through extensive diagnosis as well as their ultimate execution. In addition, all chronic complications (cardiac insufficiency, arrhythmia, pulmonary hypertension, etc.) as well as acute complications are clarified and treated (arrhythmia, endocarditis, various vascular complications, etc.) The spectrum includes the following symptoms: ...

Background. Cardiac insufficiency is one of the main causes of morbidity and mortality in the world. Objective. The aim of the study was to determine the content of interleukins in male rats with adrenaline-calcium model of myocardial injury (ACM) and under correction by quercetin. Methods. 143 Wistar male-rats aged 5-6 months were used in the experiments. The changes of interleukins (IL-1beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha) content in blood serum in the development of heart injury by adrenaline and calcium (AC) and use of quercetin for protection were studied. The period of investigation was in 1, 2, 24 hours, 3, 7, 14, 21, 28 days. Results. In ACM model of myocardial injury TNF-alpha increased, IL-2, IL-4 decreased at each period of investigation. IL-1beta increased in 2 and 3 days after the injury, at all other periods (except in 1 hour and 21 days) those indices were decreased. Also we observed similar wave changes of IL-6 and IL-10 content. Injections of quercetin for 7 days caused a

Increased susceptibility to bacterial infection is common in patients with multiple myeloma and infections can be life-threatening if not addressed. Immunodeficiency can be secondary to myelophthisis (which results in leukopenia), decreased production of functional immunoglobulin, and compromised B cell function.. Clinical signs and symptoms may be present for up to 1 year before a definitive diagnosis of multiple myeloma is made. Patients can also present with recurrent infections, non-regenerative anemia, pathologic bone fractures, and/or seizures. Complications secondary to multiple myeloma may include renal failure, infections secondary to immunosuppression, clotting disorders, chronic anemia, cardiac insufficiency, and neurologic dysfunctions such as senility.. A diagnosis of multiple myeloma may be made if there is radiographic evidence of osteolysis, there is a population of greater than 20% plasma cells in bone marrow aspirates or biopsies, a monoclonal gammopathy on serum ...

Precise regulation of microvascular tone and barrier function is essential for proper coronary perfusion and performance. Agonist-induced alterations in either or both of these functions ultimately lead to microcirculatory dysfunction and cardiac insufficiency. Two important pathways involved in r...

The material in intelligent wound dressings is a mixture of agarose and synthetic lipid vesicles that contain a self-quenching fluorescent dye. When present at high concentrations inside the vesicles, the dye is quenched and does not fluoresce. The lipid vesicles holding the dye are sensitive to cytotoxic virulence factors produced by major wound pathogens. When virulence factors from bacteria in an infected wound reach clinically relevant levels, the vesicles are lysed and the dye is dispersed. Once released, the dye is no longer at a high enough concentration to self-quench, and a fluorescence color change becomes visible. This color change can be detected through vision alone and thus is a simple yet powerful indication of clinical colonization and the need for immediate treatment. At left, the detergent Triton is used to fully lyse the vesicles, and the activated dye is visible under UV light.. The virulence factors that interact with the wound dressing occur in bacterial biofilms. ...

Hindsight is always 20/20, especially in the field of science. Given what we know now, it seems crazy that people used to think the world was flat. The realm of toxicology is filled with similar stories (see pregnancy-boosting DES and super-insecticide DDT). In the mid-twentieth century America, realization of the harmful effects of chemicals like DES and DDT contributed to rising concern about potential risks to human and environmental health associated with chemicals. Consequently, in efforts to better monitor and understand what chemicals may be harmful to humans and the environment, Congress enacted the Toxic Substance Control Act in 1976, enabling the US Environmental Protection Agency (EPA) to inventory and regulate chemicals being sold or manufactured in the US. As of 2014, 84,000 chemicals are in use in the United States (EPA TSCA).. However, even 39 years later, we know very little about the potentially harmful effects on human health and the environment of a majority of these ...

United States District Court, D. Maryland,Dec. 12, 2019,RICKEY B. TIBBS, #4410-362/166-9140, Plaintiff v. WARDEN PHILIP J. MORGAN, THE WEXFORD UM, EMMANUEL NWOSU, R.N., YETUNDE P. ROTIMI, N.P., DOCTOR YONAS SISAY, DOCTOR ATANFU, Defendants

Edward Tibbs work is very well known especially in the North East of England but also Worldwide. A versatile artist, with a wicked sense of humour, which shows through strongly in his humorous paintings of North East characters and dogs. His work...

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A 58-year-old man presented to the emergency department with sudden onset rapid palpitations and significant presyncope while walking on the flat. The previous day he had undergone DC cardioversion for atrial fibrillation (AF) which had been initially successful. However, 6 h after cardioversion he was aware of intermittently raised but regular heart rates. On arrival at the emergency department (ED) he was well with no haemodynamic compromise. The ECG showed an atrial tachycardia instead of AF. Medications consisted of propafenone 300 mg twice daily, bisoprolol 5 mg at night and warfain. Bisoprolol was increased to 5 mg twice daily and he was discharged with a plan for outpatient ablation. He collapsed in the hospital car park with rapid palpations, chest tightness and vagal symptoms. On return to the ED he was hypotensive with a heart rate of 200 bpm. The ECG showed 1:1 atrioventricular conduction (AV) of the atrial tachycardia which promptly improved after administering intravenous atenolol. ...

Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Zacharisen on clemastine fumarate: On review of the literature the two preparatio ns appear to deliver the same bisoprolol effect. It suggests that there should be no difference between the two with respect to bisoprolol effect.

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The invention is directed to nonpeptide substituted benzazepines of Formula (I), which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension, among others disclosed. Pharmaceutical compositions comprising a compound of Formula (I) and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.

Before the age of 9, Helen Tibbs Wilson knew she wanted to be a part of Alabama 4-H. It was the local Home Demonstration Club that caught her attention. At this time, Extension was two separate programs - one state office was housed at Tuskegee Institute and one was at Alabama Polytechnic Institute.. Wilson participated in 4-H at Toney Junior High School in Madison County. She won first place in the state 4-H fashion revue held at Tuskegee. Her outfit was a black corduroy skirt with a reversible vest of black corduroy and black.-and-white check fabric. She won a trip to Washington, D.C., where she won second place nationally.. Wilson also won a first-place state award in food preservation. Wilsons family grew a lot of their own produce, and she loved to preserve the fresh fruits and vegetables. She often gave demonstrations to the local Home Demonstration Club.. In addition to her 4-H project participation, Wilson attended a 4-H camp that was also held in Tuskegee. She attended camp for eight ...

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Hospital admission for congestive heart failure is extremely common and quite expensive, although it is frequently preventable. New drugs and therapies have been reported to reduce admissions, decrease morbidity and mortality, and improve the quality of life for these patients. Patients with an ejection fraction less than 40 percent (decreased systolic function) should be treated with medication to improve symptoms and prevent progression of heart failure. Angiotensin-converting enzyme (ACE) inhibitors are a mainstay of treatment in patients who can tolerate them; in patients who cannot take these drugs, angiotensin II receptor blocking agents offer an alternative. Patients with New York Heart Association class II or III heart failure should also receive a beta blocker (metoprolol, carvedilol or bisoprolol). Recent research has shown that treatment with spironolactone improves mortality and hospital readmission rates. An exercise program should also be recommended for all patients with heart failure

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Comparative Effects of Preoperative Angiotensin-converting Enzyme In-hibitor, Statin and Beta-blocker Treatment on Human Internal Mammary Artery Reactivity in Patients with Coronary Artery Disease: A Pilot Study

Takotsubo syndrome (TTS), also known as broken heart syndrome, is a severe and acute heart failure syndrome that often resolves spontaneously but can also be associated with significant mortality. TTS predominantly affects post-menopausal women and is usually triggered by identifiable physical or emotional stress. Considerable evidence suggests the precipitating factor to be the catecholamine surge from excess sympathetic activity that occurs during these events because it can be mimicked by exogenous catecholamine administration (1). TTS was first described in 1990 in Japan (2), when the shape formed by an akinetic left ventricular apex with hyperkinetic basal segments was compared to a Japanese Octopus pot, or takotsubo.. The importance of catecholamines in the induction of TTS has since been robustly demonstrated in vivo in preclinical rodent models. A number of groups have used these models to investigate the pathophysiology of TTS, including how the direct catecholaminergic myocardial ...

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Inclusion Criteria: The research subjects include a) patients after Myocardial Infarction between the ages 20 - 80 , who underwent percutaneous coronary interventions (PCI), and b) patients after a first Stroke between ages 20 - 80, up to two months after the stroke, with a NIH Stroke Score of 6 - 20 and who are able to cooperate and follow instructions.:. Exclusion Criteria:1) Unstable Angina Pectoris2) Valvular Heart disease 3) Cardiomyopathy4) uncontrolled Hypertension.5) Cardiac Insufficiency (uncontrolled)6) uncontrolled arrhythmia 7) Severe Skeletal problems, or other physical, mental or medical problems liable to limit the patient ability to participate.8) Incompliance.9) Patients who develop symptoms during the research, will be removed. ...

As we know various forms of disturbance of the rhythm of car-diac activity, causing disorders of haemodynamics, can lead to the development of a terminal state including cardiac arrest. In fact, wrote Lang, death as a result of cardiac insufficiency due to a prolonged attack of paroxysmal tachycardia is still not a rare occurrence. The most dangerous forms of arrhythmia, of course, are those leading to an immediate fatal outcome, namely ventricular fibrillation and asystolia. In that connection study of their pathogenesis and search for the most effective therapeutic measures permitting normalization of cardiac rhythm are some of the most important problems of reanimatology in recent years.. The most effective therapeutic measure when paroxysmal tachy-cardia of the ventricles develops has proved, as with ventricular fibrillation, to be that of defibrillation of the heart by means of a condenser discharge.. The possibility of treating certain forms of chronic disorders of cardiac rhythm by ...

Background: The electrical field (E-field) of the biventricular (BV) stimulation is important for the success of cardiac resynchronization therapy (CRT) in patients with cardiac insufficiency and widened QRS complex. The 3D modeling allows the simulation of CRT and high frequency (HF) ablation. Purpose: The aim of the study was to model different pacing and ablation electrodes and to integrate them into a heart model for the static and dynamic simulation of atrial and BV stimulation and high frequency (HF) ablation in atrial fibrillation (AF). Methods: The modeling and simulation was carried out using the electromagnetic simulation software CST (CST Darmstadt). Five multipolar left ventricular (LV) electrodes, one epicardial LV electrode, four bipolar right atrial (RA) electrodes, two right ventricular (RV) electrodes and one HF ablation catheter were modeled. Selected electrodes were integrated into the Offenburg heart rhythm model for the electrical field simulation. The simulation of an AV ...

A congenital malformation, in which the partition wall between the heart chambers is not perfect and blood passage through the septum is possible.. The defect can be located in the septum separating the upper compartments of the heart (atrial septal defect, ASD) or in the septum dividing the ventricles (ventricular septal defect, VSD).. The presence of such defect results in leakage of blood, predominantly from the left side, where pressure is higher, to the right. The right side will have to cope with greater load and this can result in Pulmonary Hypertension with subsequent cardiac insufficiency. If necessary, such defects can be surgically repaired.. ...

Clinical Trials - clinicaltrials.gov Infectious myocardities are frequent, most of the time viral and can evolve to cardiac insufficiency. The diagnostic is dif...

This trial investigated the efficacy and tolerability of carvedilol in Japanese patients with mild-to-moderate chronic heart failure. The primary endpoint was a

David A. Steinman; Yiemeng Hoi; Paul Fahy; Liam Morris; Michael T. Walsh; Nicolas Aristokleous; Andreas S. Anayiotos; Yannis Papaharilaou; Amirhossein Arzani; Shawn C. Shadden; Philipp Berg; Gábor Janiga; Joris Bols; Patrick Segers; Neil W. Bressloff; Merih Cibis; Frank H. Gijsen; Salvatore Cito; Jordi Pallarés; Leonard D. Browne; Jennifer A. Costelloe; Adrian G. Lynch; Joris Degroote; Jan Vierendeels; Wenyu Fu; Aike Qiao; Simona Hodis; David F. Kallmes; Hardeep Kalsi; Quan Long; Vitaly O. Kheyfets; Ender A. Finol; Kenichi Kono; Adel M. Malek; Alexandra Lauric; Prahlad G. Menon; Kerem Pekkan; Mahdi Esmaily Moghadam; Alison L. Marsden; Marie Oshima; Kengo Katagiri; Véronique Peiffer; Yumnah Mohamied; Spencer J. Sherwin; Jens Schaller; Leonid Goubergrits; Gabriel Usera; Mariana Mendina; Kristian Valen-Sendstad; Damiaan F. Habets; Jianping Xiang; Hui Meng; Yue Yu; George E. Karniadakis; Nicholas Shaffer; Francis ...

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