Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Symptoms of bipolar disorder are severe. They are different from the normal ups and downs that everyone goes through from time to time. Bipolar disorder symptoms can result in damaged relationships, poor job or school performance, and even suicide. But bipolar disorder can be treated, and people with this illness can lead full and productive lives.. Causes. Scientists are studying the possible causes of bipolar disorder. Most scientists agree that there is no single cause. Rather, many factors likely act together to produce the illness or increase risk.. Genetics. Bipolar disorder tends to run in families. Some research has suggested that people with certain genes are more likely to develop bipolar disorder than others. Children with a parent or sibling who has bipolar disorder are much more likely to develop the ...
After reviewing numerous clinical trials, the American Heart Association issued a scientific statement that mentioned children and adolescents with major depressive disorder or bipolar disorder are at increased risk for cardiovascular diseases later in life. The statement was published online in Circulation on Aug. 10.
Appropriate medication depends on the stage of the bipolar disorder, or manic-depressive illness (MDI), the patient is experiencing. Thus, a number of drugs are indicated for an acute manic episode, p... more
Both Schizophrenia and bipolar disorders are problems in the thought processes of a human being. They are both very distressing conditions, with a degree of difference in symptoms and treatments. While it is very difficult for non medical people to differentiate between the two conditions, there are some differences that are evident to observers.. The most obvious differences between Schizophrenia and bipolar disorder are evident during the initial onset of the condition. Almost 30% of people who are diagnosed with bipolar disorder report that their condition started off with depression. A similar number of people also report that they had manic symptoms when their disease first started off. Only 9% of those surveyed remember psychotic experiences at the start of the disease ...
OBJECTIVE: The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) is designed to evaluate the longitudinal outcome of patients with bipolar disorder. The STEP-BD disease-management model is built on evidence-based practices and a collaborative care approach designed to maximize specific and nonspecific treatment mechanisms. This prospective study examined the longitudinal relationships between patients satisfaction with care, levels of hope, and life functioning in the first 1000 patients to enter STEP-BD. METHODS: The study used scores from the Care Satisfaction Questionnaire, Beck Hopelessness Scale, Range of Impaired Functioning Tool, Young Mania Rating Scale, and Montgomery-Asberg Depression Rating Scale at 5 time points during a 1-year interval. Analyses tested mediational pathways between care satisfaction, hope, and life functioning, depression, and mania using mixed-effects (random and fixed) regression models. RESULTS: Increases in care satisfaction were associated with
Definition of Mixed States Sack in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Mixed States Sack? Meaning of Mixed States Sack as a finance term. What does Mixed States Sack mean in finance?
A number of reasons exist for obtaining selected laboratory studies in patients with bipolar disorder, or manic-depressive illness (MDI). An extensive range of tests is indicated, because bipolar diso... more
OBJECTIVES: Conventional descriptions of bipolar disorder tend to treat the mixed state as something of an afterthought. There is no scale that specifically measures the phenomena of the mixed state. This study aimed to test a novel scale for mixed state in a clinical and community population of bipolar patients. METHODS: The scale included clinically relevant symptoms of both mania and depression in a bivariate scale. Recovered respondents were asked to recall their last manic episode. The scale allowed endorsement of one or more of the manic and depressive symptoms. Internal consistency analyses were carried out using Cronbach alpha. Factor analysis was carried out using a standard Principal Components Analysis followed by Varimax Rotation. A confirmatory factor analytic method was used to validate the scale structure in a representative clinical sample. RESULTS: The reliability analysis gave a Cronbach alpha value of 0.950, with a range of corrected-item-total-scale correlations from 0.546 (weight
We aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and research uses of the biobank, along with demographics and clinical features of the first participants enrolled. Patients were recruited for the Mayo Clinic Bipolar Biobank beginning in July 2009. The Structured Clinical Interview for DSM-IV was used to confirm bipolar diagnosis. The Bipolar Biobank Clinical Questionnaire and Participant Questionnaire were designed to collect detailed demographic and clinical data, including clinical course of illness measures that would delineate differential phenotypes for subsequent analyses. Blood specimens were obtained from participants, and various aliquots were stored for future research. As of September 2014, 1363 participants have been enrolled in the bipolar biobank. Among these first participants, 69.0 % had a diagnosis of bipolar disorder type I. The group
Bipolar disorder dates back to the time of Hippocrates (Healy). Hippocrates was the first to put mania and melancholia on our cultural radar (Healy). The symptoms he used to diagnose mania were that of nausea, shivering, insomnia, and lack of thirst (Healy). Until recently, bipolar II disorder has been virtually unknown and highly underdiagnosed. DSM-IV has separated bipolar disorders into two types, bipolar II and I. (Chengappa, Levine, Gershon, Kupfer). These two disorders may have differing genetic, biological, phenomenological attributes and course of illness characteristics (Chengappa, Levine, Gershon, Kupfer). There are many reasons for this. A lack of education regarding the disorder, misdiagnosis, and improper treatments are the number one reason for misdiagnosis. Physicians and mental health clinicians are just now learning the symptoms of bipolar II disorder. During a 2005 chart review, 37% of 90 bipolar II disorder patients were misdiagnosed as having unipolar depression. Bipolar II ...
Bipolar disorder not otherwise specified (BD-NOS) is a diagnosis for bipolar disorder (BD) when it does not fall within the other established sub-types. Bipolar disorder NOS is sometimes referred to as subthreshold bipolar disorder. BD-NOS is a mood disorder and one of three subtypes on the bipolar spectrum, which also includes bipolar I disorder and bipolar II disorder. BD-NOS was a classification in the DSM-IV and has since been changed to Bipolar "Other Specified" and "Unspecified" in the 2013 released DSM-5 (American Psychiatric Association, 2013). Bipolar disorder is difficult to diagnose. If a person displays some symptoms of bipolar disorder but not others, the clinician may diagnose bipolar NOS. The diagnosis of bipolar NOS is indicated when there is a rapid change (days) between manic and depressive symptoms and can also include recurring episodes of hypomania. Bipolar NOS may be diagnosed when it is difficult to tell whether bipolar is the primary disorder due to another general ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a persons mood, energy, and ability to function. Different from the normal ups and downs that everyone goes through, the symptoms of bipolar disorder are severe. They can result in damaged relationships, poor job or school performance, and suicide. Bipolar disorder causes dramatic mood swings-from overly high and/or irritable to sad and hopeless, and then back again, often with periods of normal mood in between. Severe changes in energy and behavior go along with these changes in mood.. The precise neural basis of BD is unknown. In CIBSR, we are endeavoring to uncover some of the functional differences in brains of individuals with BD compared with normal individuals.. For ongoing research at Stanford click here.. For publications on this research click here.. ...
Does someone you care about have bipolar disorder? Symptoms of bipolar disorder - whether associated with a manic, depressive, or mixed state - can cause concern. With some basic information about bipolar disorder, knowledge of resources and interpersonal strategies, and compassion for yourself and others, you can provide meaningful support to a person with bipolar disorder. Keeping lines of communication open and planning ahead as much as possible help immeasurably in living with bipolar disorder.. Follow the buttons below for educational resources about bipolar disorder and the role of a caregiver to an adult living with bipolar disorder. We hope they help you and your family work together toward wellness.. ...
Bipolar II disorder: Find the most comprehensive real-world symptom and treatment data on bipolar II disorder at PatientsLikeMe. 8829 patients with bipolar II disorder experience irritability, fatigue, flight of ideas, grandiose thinking, and anxious mood and use Lamotrigine, Individual Therapy, Quetiapine, Lithium Carbonate, and Lurasidone to treat their bipolar II disorder and its symptoms.
Manic-depressive illnesses (Manic-depressive psychoses). These disorders are marked by severe mood swings and a tendency to remission and recurrence. Patients may be given this diagnosis in the absence of a previous history of affective psychosis if there is no obvious precipitating event. This disorder is divided into three major subtypes: manic type, depressed type, and circular type.. 296.1 Manic-depressive illness, manic type ((Manic-depressive psychosis, manic type)). This disorder consists exclusively of manic episodes. These episodes are characterized by excessive elation, irritability, talkativeness, flight of ideas, and accelerated speech and motor activity. Brief periods of depression sometimes occur, but they are never true depressive epi- sodes.. 296.2 Manic-depressive illness, depressed type ((Manic-depressive psychosis, depressed type)). This disorder consists exclusively of depressive episodes. These episodes are characterized by severely depressed mood and by mental and motor ...
Introduction. Bipolar disorder is a recurrent and chronic disorder with significant morbidity and mortality. It is characterized by a long-term episodic cyclical course of extreme fluctuations in mood that manifest as repeated manic, depressed, or mixed episodes with complete inter-episode recovery but high rates of chronicity that impact social and occupational development (Angst & Sellaro, 2000). According to the Systematic Treatment Enhancement Program for Bipolar Disorder, 5% of patients who fulfill the criteria for recovery suffer relapses each month (Baldassano, 2006). Although some rare individuals may experience only a single episode of mania and depression in their lifetime, ,95% of people with bipolar disorder have recurrent episodes of mania and depression throughout their lives (Goodwin & Jamison, 1990).. Bipolar disorder is a common disorder that affects 1% of the population. This prevalence may increase according to the diagnostic criteria used in each study (Judd & Akiskal, 2003). ...
Bipolar affective disorder is a severe, heritable condition affecting about one percent of. the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed. ...
Bipolar affective disorder is a severe, heritable condition affecting about one percent of. the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed. ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in a persons mood, energy, and ability to function.. The mood episodes associated with the disorder persist from days to weeks or longer, and can be dramatic, with periods of being overly high and/or irritable to periods of persistent sadness and hopelessness.. Severe changes in behavior go along with the mood changes. These periods of highs and lows, called episodes of mania and depression, can be distinct episodes often recurring over time, or they may occur together in a so-called mixed state. Often people with bipolar disorder experience periods of normal mood in between mood episodes.. A manic episode is diagnosed if an elevated mood occurs with three or more primary symptoms most of the day, nearly every day, for at least one week. With an irritable mood, four additional symptoms must be present for a diagnosis.. Signs and symptoms of a manic episode can include the following:. ...
In 2017 the US Food and Drug Administration approved a monthly injectable form of the atypical antipsychotic drug aripiprazole, Abilify Maintena, for the prevention of manic and mixed episodes in bipolar I disorder. The intramuscular injections are available for monotherapy in preparations of 300 mg or 400 mg. Maintena did not prevent depressive episodes.. Maintena is already FDA-approved for the treatment of schizophrenia and Tourettes syndrome in adults.. The approval for bipolar I disorder follows a 52-week phase 3, double-blind, placebo-controlled randomized trial. Participants were experiencing a manic episode during screening for the study, met the criteria for bipolar I disorder, and had had at least one prior manic or mixed episode severe enough to require treatment.. Compared to placebo, Maintena in once-a-month injections delayed the recurrence of any mood episode following the initial manic episode at screening. When the researchers separated their analysis based on type of episode, ...
Children who have a parent with bipolar disorder are at risk for bipolar illness, but it may first present as depression. Treating these children with antidepressants has the risk of bringing on manic episodes. Researchers are looking for treatment options for youth at risk for bipolar disorder.. Robert McNamara and colleagues found that 12 weeks of omega-3 fatty acids (2,100 mg/day) significantly improved response rates in medication-free youth ages 9-20 years compared to placebo (64% versus 36%). Omega-3 fatty acids but not placebo also reduced the activation of limbic structures in the brain (the left parahippocampal gyrus) in response to emotional stimuli.. Editors Note: These data add to the literature on the positive effects of 1-2 grams of omega-3 fatty acids in depression. Given the safety of omega-3 fatty acids and the ambiguous effects of antidepressants in bipolar depression, omega-3 fatty acids would appear to a good alternative, especially since the FDA-approved atypical ...
Levy B. Autonomic nervous system arousal and cognitive functioning in bipolar disorder. Bipolar Disord 2012: 00: 000-000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd.. Objective: Previous theories about the etiology of cognitive dysfunction in bipolar disorder (BD) emphasized trait factors such as neurological impairment. State factors, other than mood symptoms, that may exacerbate functional deficits have not yet been considered. The purpose of this study was to examine autonomic nervous system (ANS) arousal following cognitive challenge. The study compared patients with BD and healthy controls (HC) in physiological measures and neuropsychological test scores.. Methods: Thirty euthymic patients with BD and 22 HC completed the study. Participants completed mood [Beck Depression Inventory-II (BDI-II) and Young Mania Rating Scale (YMRS)], anxiety (State-Trait Anxiety Inventory), and substance abuse (Drug Abuse Screening Test-20 item and Alcohol Use Disorders Identification ...
The anesthetic ketamine (sometimes illicitly-used as a recreational drug) produced rapid alleviation of severe depression in patients with treatment-resistant bipolar illness in a small clinic trial.
The results of the meta-analysis suggest that individuals with bipolar disorder are 2.6 times more likely to experience childhood adversity when compared with a non-clinical control group. This effect did not appear to be the result of study design or bias, and remained robust and significant even after controlling for hypothetically missing studies. The findings should be interpreted in the context of relatively few longitudinal studies and none with a prospective cohort design, limiting the ability to make causal inferences. Nevertheless, there appears to be a strong and significant association between childhood adversity and bipolar disorder.. We found some variances in this association when specific types of exposure were analysed separately. Emotional abuse was four times more likely to have occurred in bipolar disorder groups than in healthy controls, an effect seemingly larger than for other types of adversity. This is in contrast to a recent meta-analysis that observed roughly equivalent ...
In the present study we leveraged the power of GWAS data from two independent schizophrenia and bipolar disorder samples, and demonstrate how GWAS from associated psychiatric disorders can improve discovery of novel susceptibility loci. Using standard GWAS analytical methods, we identified only one significant locus. By applying traditional FDR methods in the separate GWAS samples, we found an additional 6 loci (2 in bipolar disorder, 4 in schizophrenia). Combining the independent schizophrenia and bipolar disorder GWAS samples, we identified a total of 58 loci in schizophrenia and 35 in bipolar disorders, with conditional FDR,0.05 as a threshold. Nine of the current loci have been identified earlier in larger samples using standard GWAS analytical methods (7 in schizophrenia, 5 in bipolar disorder, and 3 in combined samples), while 10 other loci have been reported to show borderline association with bipolar disorder or schizophrenia (Table S1). These results demonstrate the feasibility of using ...
Post a Comment for Manifest Psychopathology and Urine Biochemical Measures (Multivariate Analysis in Manic-Depressive Illness) ...
The specificities of the RNA transcripts which we found to be present at elevated levels in the frontal cortex of individuals with bipolar disorder are of interest in terms of possible pathophysiological mechanisms of this disease. Previous research data suggest that serotonin plays a central role in neural communication within the central nervous system. Furthermore, levels of serotonin can affect mood, appetite, sleep, pain perception and several aspects of human behaviour (Kanner & Schuldiner, 1987; Amara & Kuhar, 1993; Young et al, 1996). The emerging understanding of the biological properties of serotonin has led to considerable interest in the possible role of the serotonin transporter gene in determining susceptibility to bipolar disorder. While mutations in the coding region have not been found, several studies have documented an association between the variable number of tandem repeats in the transcriptional control region of the gene and the occurrence of bipolar disorder (Battersby et ...
Although the concept of mixed states had been well accepted by many of his contemporaries, including Bleger ("Outline of Psychiatry", 1924), not all of them recognized the concept at the time the premises of his formulas were published. "Breaking" the manic-depressive illness into the affective, intellectual and cognitive spheres seemed unacceptable to Jaspers. Jaspers stated: "The procedure is ambiguous since the meaningful connections are approached as objective components of psychic life (capable of being separated and mechanically joined)".13 Schneider14 was even more emphatic: "We no longer believe in mixed states. ( ) What may give the appearance of mixed states consists of the change from one state to another, in a way that we may simply call them cyclothymia" ("cyclothymia" was the term used by Schneider for the manic-depressive illness as a whole). On the other hand, Leonhard,15 a disciple of Kleist, not only accepted but emphasized the importance of the "mixed" characteristics in the ...
Bipolar disorder - What are the symptoms of bipolar disorder like? Varied. The symptoms vary depending on the type of bipolar disorder. There is bipolar i, bipolar ii, cyclothymia and bipolar disorder nos. Manic symptoms can include a marked increase in energy and decreased need for sleep, racing thought, rapid speech, euphoric mood, hypersexual, hyper religious, grandiose delusion, etc. Depression in bipolar disorder often looks like unipolar depression.
BACKGROUND: Bipolar disorder is a common recurrent illness with high levels of chronicity. Treatment resistance persists despite the use of established medications, such as lithium and valproate. New medications are required for the treatment of refractory cases. Retrospective and open-label trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. There is a need to clarify the evidence available in the form of randomised controlled trials for its use in bipolar disorder. OBJECTIVES: To review the evidence for the efficacy and acceptability of topiramate in the treatment of acute mood episodes in bipolar disorder. SEARCH STRATEGY: The Cochrane Collaboration Depression, Anxiety and Neurosis (CCDAN) group search strategy was used. The following databases were searched:The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register (CCDANCTR), September 2003;The Cochrane Controlled Clinical Trials Register (CCCTR), September 2003;EMBASE (1980
Background. Evidence suggests that a positive family history of bipolar affective disorder is associated with response to lithium and the course of the illness, in people suffering from this disorder. This may indicate a subgroup of patients with unique characteristics and treatment responses.. Aims. To explore associations between a positive family history of bipolar disorder and the risk of violence, in patients hospitalized for treatment of mania.. Methods. Adults receiving inpatient treatment for a manic relapse of bipolar affective disorder, at two tertiary care hospitals in Kandy, Sri Lanka were studied as a cohort. For each participant with a positive family history of bipolar disorder, an age and gender matched adult, also suffering from a manic relapse of bipolar affective disorder but without a family history, was included as a control. A second researcher, who was blind to the participants family history, assessed the risk of violence among all participants, at baseline, and at ...
Both schizophrenia and bipolar disorder are characterized as psychiatric disorders in the Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5). Schizophrenia is a primary psychotic disorder, and bipolar disorder is a primary mood disorder but can also involve psychosis. However, because of some similar symptoms, differentiating between the two can sometimes be difficult; indeed, there is an intermediate diagnosis schizoaffective disorder. While reported and observed symptoms are a main way to diagnose either disorder, recent research studies are allowing psychiatrists to use magnetic resonance imaging (MRI) scans to try to find better, definite markers. Through MRIs, the psychiatrists can see specific structural differences in the brain that psychiatric medicines have made in the patient. These differences include volume of gray matter, neuropathological size differences variations, and cortical thickness, which then associated with cognitive differences on tests. These ...
Objective: To study the efficacy of adjunctive levetiracetam therapy compared with placebo in the treatment of subjects with depression with bipolar disorder.. Method: This double-blind, placebo-controlled clinical trial randomly assigned outpatients with bipolar disorder type I and type II who were experiencing a major depressive episode (Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version criteria) to treatment with either placebo or adjunctive levetiracetam (up to 2,500 mg/d flexibly dosed) for 6 weeks. The subjects were recruited from October 2005 to June 2008. The primary efficacy measure was mean change from baseline to week 6 in the Hamilton Depression Rating Scale (21-item). Secondary efficacy assessments included the Montgomery-Åsberg Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impressions-Bipolar Version scale, the Hamilton Anxiety Rating Scale, and the Young Mania Rating Scale.. Results: Of 42 subjects randomly assigned to ...
Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks.. There are four basic types of bipolar disorder; all of them involve clear changes in mood, energy, and activity levels. These moods range from periods of extremely "up," elated, and energized behavior (known as manic episodes) to very sad, "down," or hopeless periods (known as depressive episodes). Less severe manic periods are known as hypomanic episodes.. ...
Comorbidity is the rule, not the exception, in bipolar disorder. The most common mental disorders that co-occur with bipolar disorder in community studies include anxiety, substance use, and conduct disorders. Disorders of eating, sexual behavior, attention-deficit/hyperactivity, and impulse control, as well as autism spectrum disorders and Tourettes disorder, co-occur with bipolar disorder in clinical samples. The most common general medical comorbidities are migraine, thyroid illness, obesity, type II diabetes, and cardiovascular disease. Bipolarity is a marker for comorbidity, and comorbid disorders, especially multiple conditions occurring when a patient is young, may be a marker for bipolarity. Relatively few controlled clinical studies have examined the treatment of bipolar disorder in the context of comorbid conditions (i.e., complicated or comorbid bipolar disorder). However, the first step in treating any type of complicated bipolar disorder-stabilizing a patients mood-may be ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Bipolar Disorder Pipeline Review, H2 2016, latest research study provides in depth analysis on Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13) targeted pipeline therapeutics.. Bipolar Disorder therapeutics industry report provides comprehensive information on the therapeutics under development for Bipolar Disorder, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Bipolar Disorder and features dormant and discontinued projects.. Bipolar disorder was formerly called manic depression. It is a form of major affective disorder, or mood disorder, ...
Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry. 2003 Feb;64(2):161-74. PubMed PMID: 12633125.. McElroy SL, Altshuler LL, Suppes T, Keck PE Jr, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001 Mar;158(3):420-6. PubMed PMID: 11229983.. Simon NM, Otto MW, Weiss RD, Bauer MS, Miyahara S, Wisniewski SR, Thase ME, Kogan J, Frank E, Nierenberg AA, Calabrese JR, Sachs GS, Pollack MH; STEP-BD Investigators. Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD. J Clin Psychopharmacol. 2004 Oct;24(5):512-20. PubMed PMID: 15349007.. ...
Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. This condition is a serious lifelong struggle and challenge.
This study aims to characterize the atypical developmental trajectory of functional brain circuitry and neurocognitive function in adolescent bipolar disorder (...
Bipolar disorder is regarded as a disorder of mood and initial studies have focused on structural abnormalities in limbic networks, known to subserve mood. More recently, functional imaging studies allude to affect processing deficits, which may involve frontostriatal networks. This study sought to explore disturbances in networks involved in the processing of negative affect in euthymic bipolar patients. We used simultaneous functional magnetic resonance imaging and galvanic skin responsivity to explore disturbances in these networks. When processing negative affect, controls recruited a distributed subcortical-prefrontal network. In contrast, patients could only activate a subcortical network that included the amygdala and hippocampus. This study provides evidence for a disconnection in the transfer of information within frontostriatal networks in bipolar disorder. © 2007 Lippincott Williams & Wilkins, Inc.
Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of approximately 80% indicating a substantial genetic component. Population genetics and genome-wide association studies suggest an overlap of genetic risk factors between these illnesses but it is unclear how this genetic component is divided between common gene polymorphisms, rare genomic copy number variants, and rare gene sequence mutations. We report evidence that the lipid transporter gene ABCA13 is a susceptibility factor for both schizophrenia and bipolar disorder. After the initial discovery of its disruption by a chromosome abnormality in a person with schizophrenia, we resequenced ABCA13 exons in 100 cases with schizophrenia and 100 controls. Multiple rare coding variants were identified including one nonsense and nine missense mutations and compound heterozygosity/homozygosity in six cases. Variants were genotyped in additional schizophrenia, bipolar, depression (n , ...
There is strong evidence that genetic factors make substantial contributions to the etiology of autism, schizophrenia and bipolar disorders, with heritability estimates being at least 80% for each. These illnesses have complex inheritance, with multiple genetic and environmental factors influencing disease risk; however, in psychiatry, complex genetics is further compounded by phenotypic complexity. Autism, schizophrenia and bipolar disorder are effectively syndromic constellations of symptoms that define groups of patients with broadly similar outcomes and responses to treatment. As such the diagnostic categories are likely to be heterogeneous and the boundaries between them somewhat arbitrary. Recent applications of whole-genome technologies have discovered rare copy number variants and common single-nucleotide polymorphisms that are associated with risk of developing these disorders. Furthermore, these studies have shown an overlap between the genetic loci and even alleles that predispose to the
Many people with undiagnosed bipolar disorder may end up in the hospital during a manic episode. Once the patient has stabilized, they may be sent to a psychologist for a diagnosis. The therapist will ask about symptoms the person has suffered, including how long symptoms last. In some cases, a person with bipolar disorder is initially misdiagnosed with depression or anxiety, which are common mood disorders, and begins to receive treatment for those issues. If treatment does not work or it triggers a manic episode, then the therapist will try a different approach. ...
People with bipolar disorder are sometimes treated with antiepileptic drugs but there have been worries that these can increase peoples suicide risk. Researchers from the University of Illinois at Chicago studied 47,918 people with bipolar disorder, 13,385 of whom were taking antiepileptics. They found that those taking the antiepileptic drugs had similar rates of suicide attempts as those taking lithium or those people who were taking no medication at all. In fact after people started taking the antiepileptic drugs they had a significantly lower rate of suicide attempts than before they had started taking them. Relative to taking no medication at all taking antiepileptic medication led to a fivefold decrease in risk ...
... s are one of several medical conditions called depressive disorders that affect the way a persons brain functions. Find out more about bipolar disorder.
... s are one of several medical conditions called depressive disorders that affect the way a persons brain functions. Find out more about bipolar disorder.
In the bipolar disorder story success. The fees charged vary depending on the market achieved FDA approval for adult Attention Deficit are often uncomfortable in new or unfamiliar environments since they may seem normal when they talk and understand how to accept and live successfully with bipolar disorder need therapists who help them exercise cognitive control of emotions. Interpersonal therapy focuses on developing the bipolar disorder story success and resolve interpersonal conflicts, which frequently accompany bipolar disorder. Both of these conditions, it is probably determined by multiple factors. Family and adoption studies have been conducted to pin down its cause, but up to the bipolar disorder story success a change in fashion, and constantly checking their weight. Some social changes of a series of stressful events in a major cause of eating disorders. Singer Karen Carpenter was struggling with anorexia may also be mental retardation if it is unclear which came first, the bipolar ...
Bipolar affective disorder, or manic-depressive illness (MDI), is a common, severe, and persistent mental illness. This condition is a serious lifelong struggle and challenge.
Wednesday, 18 July 2012 20:09 A Solution for Treating Bipolar Disorder. The Merck Manual describes bipolar disorder as "a condition in which periods of depression alternate with periods of mania or lesser degrees of excitement." 1 Historically known as manic-depressive disorder, this psychiatric condition is typically defined by the presence of abnormally elevated energy levels affecting mood and awareness, with or without states of depression. Manic states are often accompanied by psychotic symptoms such as delusions and hallucinations.. Allopathic medicines solution generally involves one or more pharmaceuticals for a lifetime; it never offers a cure but rather, management of erratic behavior via medications that often need to be changed from time to time. Quite commonly, those suffering from bipolar disorder are very bright, creative and loving individuals. Sadly, when brain chemistry goes out of balance, the sufferer most often deals with chaos involving hallucinations, as well as extreme ...
Aims. To determine the prevalence of women of childbearing age with schizophrenia and bipolar disorder exposed to antipsychotic (AP) drugs and mood stabilizers (MS) in Lombardy, a European region of 10 million inhabitants and 1 752 285 women of childbearing age. Methods. The data concerning psychiatric care, drug treatments and pregnancy outcomes were retrieved from local administrative databases during a 12-month census period. Results. During a 12-month census period, 2893 women of childbearing age with schizophrenia (74.8% of all women of childbearing age with schizophrenia) and 918 with bipolar disorder (80.1% of all women of childbearing age with bipolar disorder) were exposed to AP drugs or MS, yielding a prevalence of exposure for women with schizophrenia of 1.65 (95% confidence interval (CI) 1.59-1.71) per 1000 female inhabitants, and for women with bipolar disorder of 0.52 (95% CI 0.49-0.55) per 1000 female inhabitants. Persistent exposure to potentially teratogenic medications accounted for
Professor Hugh Gurling, UCL Department of Mental Health Sciences, says: "The next step is to determine the role of the Slynar gene in the brain and how abnormalities in this gene may cause bipolar disorder. Using techniques such as animal models will help us to fully understand the mechanisms behind this gene and explore how we might be able to intervene in these mechanisms, to help people with the disorder. "We hope our discovery will eventually lead to new treatments for depression and bipolar disorder, including possible preventive strategies, for example with drugs or even through nutritional intervention." Around one in every 200 people in the UK develops bipolar and other related mood disorders. Signs of depression include losing weight, feeling totally negative about oneself, feel hopeless about the future and sometimes ending up in a depressive stupor in bed, unable to move, eat, drink or talk. People with bipolar disorder may also experience extreme mood highs, overactivity, increased ...
Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar susceptibility and pathogenesis are yet to be identified. Genetic linkage analysis has identified a bipolar disorder susceptibility locus on chromosome 4q35, and the interval harbouring this susceptibility gene has been narrowed to a size that is amenable to positional cloning. We have used the resources of the Human Genome Project (HGP) and Celera Genomics to identify overlapping sequenced BAC clones and sequence contigs that represent the region implicated by linkage analysis. A combination of bioinformatic tools and laboratory techniques have been applied to annotate this DNA sequence data and establish a comprehensive transcript map that spans approximately 5.5 Mb. This map encompasses the
Being bipolar and living with the illness means that you should have a bipolar disorder treatment plan in place. This usually begins to be formed from the time that a diagnosis of bipolar disorder is made. Often the bipolar disorder treatment is split into two types - one for treating manic episodes and one for treating depressive episodes.
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This page provides relevant content and local businesses that can help with your search for information on Bipolar Disorder Treatments. You will find informative articles about Bipolar Disorder Treatments, including Bipolar Disorder. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in North Pole, AK that can help answer your questions about Bipolar Disorder Treatments.
In this show Michael Pipich, MS,LMFT, therapist and national speaker on Bipolar Disorder, draws upon his new book, Owning Bipolar: How Patients and Families Can take Control of Bipolar Disorder to make owning and properly treating Bipolar Disorder a reality. | Owning Bipolar Disorder - A Guide for Patients and Family Thursday, October 4, 2018 on Psych Up Live | VoiceAmerica - The Leader in Internet Media
Transcript Bipolar illnesses comprise of depressive episodes, as well as, distinct manic episodes. And briefly in a manic episode it can be thought short hand
American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 147B:914 -917 (2008) Association of DAO and G72(DAOA)/G30 Genes With Bipolar Affective Disorder Diana Prata,1,2 Gerome Breen,1,2 Sarah Osborne,2 Janet Munro,2 David St. Clair,3 and David Collier1,2* 1 Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK Division of Psychological Medicine, Institute of Psychiatry, London, UK 3 Department of Mental Health, University of Aberdeen, Aberdeen, UK 2 There is growing evidence of partial aetiological overlap between schizophrenia and bipolar disorder (BP) from linkage analysis, genetic epidemiology and molecular genetics studies. In the present study we investigated whether individual polymorphisms or haplotypes of the DAO and G72(DAOA)/G30 genes, which have been previously implicated in schizophrenia, are also associated with bipolar disorder. For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: ...
The offspring of individuals with bipolar disorder are at increased risk of mental illness, but our tools to predict which of these genetically at-risk young people will eventually develop disorder are very imprecise. Longitudinal studies that ascertain at-risk participants and monitor them prospectively are an effective approach for identifying early clinical and biological markers of future illness. In collaboration with the Black Dog Institute plus groups from four independent US-based sites, including: Johns Hopkins University; University of Michigan; Washington University in St. Louis; Indiana University; we are following a cohort of young kids and siblings of bipolar disorder patients with annual clinical, neurocognitive and lifestyle assessments; plus bi-annual brain imaging of the Australian participants. We are assessing the genetic load of multiple risk variants across the genome in these at-risk individuals to determine if we can use genetic information to help predict which ...
Bipolar Disorder is a common and complex mental disorder with a prevalence of 1-2 % and accounts as one of the most important causes of disability at age 15-44 years worldwide. The disorder is a long-term heterogeneous illness with a continued need for treatment and naturalistic follow-up studies suggest that the progressive development of bipolar disorder is not prevented with the present treatment options. Electronic versions of self-monitoring tools and symptom registration using computers, personal digital assistants (PDAs), text messages, and web interfaces have been described in the literature and a number of commercial Smartphone applications (e.g. Optimism, MoodRythm, iMoodJournal, eMoods Bipolar Disorder Tracker, Bipolar Bear, Moody Me etc.) for patients with bipolar disorder are available on the market.. ...
(Medical Xpress)-Adolescents with bipolar disorder are more likely to develop substance use disorders than adolescents without psychiatric disorders. Now, researchers at the University of Cincinnati (UC) have identified specific risk factors underlying this relationship.
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I am writing this because after being diagnosed with bipolar disorder, although I was surrounded by love and support from my family and friends, I never felt more alone.
How does the bipolar disorder affects girls. Teenagers with suicidal depression for several days before menstrual period. How to treat bipolar illness in girls and how it affects their sexual feelings.
Suicidal Behavior in Alcohol and Drug Abuse and Dependence. Hauppauge, New York: Nova Science Publishers, 2010, 540 pages. Background. Bipolar disorder is a frequent and chronic affective illness associated with significant global dysfunction and suicidal behavior. Bipolar patients frequently have other Axis I psychiatric disorders such as substance abuse or dependence affecting up to 60% of these individuals. Substance use disorders can independently lead to risk-taking behaviors and suicidality. Therefore, we gathered data about bipolar disorder and substance use disorders as single and as combined factors leading to suicidal behavior. We also discussed some neurobiological findings related to this comorbidity.. Methods. We reviewed the Medline database in search for studies published in English, Spanish or Portuguese until June 1st 2009, containing the following keywords: "bipolar disorder", "suicidal behavior", "suicide", "substance use disorders", "alcohol", "drugs", "cocaine", "cannabis", ...
It has been conventional for psychiatric research, including the search for predisposing genes, to proceed under the assumption that schizophrenia and bipolar disorder are separate disease entities with different underlying etiologies. These represent Emil Kraepelins traditional dichotomous classification of the so-called "functional" psychoses and form the basis of modern diagnostic practice. However, findings emerging from many fields of psychiatric research do not fit well with this model. In particular, the pattern of findings emerging from genetic studies shows increasing evidence for an overlap in genetic susceptibility across the traditional classification categories-including association findings at DAOA(G72), DTNBP1 (dysbindin), COMT, BDNF, DISC1, and NRG1. The emerging evidence suggests the possibility of relatively specific relationships between genotype and psychopathology. For example, DISC1 and NRG1 may confer susceptibility to a form of illness with mixed features of ...
In recent years the diagnostic status of people with depression who become hypomanic during antidepressant therapy has been a contentious issue. Many psychiatrists believe that in patients with no previous history of hypomania, brief periods of hypomania occurring within weeks of starting antidepressants should not necessarily lead to a diagnosis of bipolar illness. In DSM-III-R, antidepressant-associated hypomania was considered part of the bipolar spectrum, whereas in DSM-IV it is categorised as a substance-induced mood disorder. However, a consensus is re-emerging that people with depression who experience antidepressant-associated hypomania are truly bipolar.. This is a difficult area because many of the original descriptions of antidepressant-induced hypomania did not distinguish between patients with pre-existing diagnoses of unipolar or bipolar disorder. In addition, most treatment trials of antidepressants for depression do not systematically assess patients for hypomanic symptoms ...
Interpersonal and Social Rhythm Therapy (IPSRT) is an empirically-supported individual psychotherapy for the treatment of adults with bipolar disorder. This innovative approach to the management of bipolar disorder was developed by Ellen Frank and colleagues at the University of Pittsburgh and has now been shown to be efficacious in preventing relapse of mania and depression and in treating acute episodes of bipolar depression when used in combination with pharmacotherapy. Open studies suggest that it has utility as a monotherapy for adults with bipolar II disorder and for adolescents with bipolar I or II illness. IPSRT combines a behavioral approach to increasing the regularity of daily routines (social rhythms) with an interpersonal approach to coping with the stresses of the bipolar illness itself, as well as with common interpersonal stressors and social role problems. This approach has now been expanded to include group models for inpatient, intensive outpatient (day-hospital) and standard ...
Addiction and Bipolar Disorder are closely linked. Call 866.267.3273 to learn more about dual diagnosis treatment at Lakeview Health.
The original paper: Miura et al. Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: A systematic review and network meta-analysis. Lancet Psych 2014;1:351-359. The EBMH commentary by Charles Bowden will be freely available as soon as it is published online first. (We will post the link soon.). In many clinical guidelines, lithium is considered the established standard in the long-term treatment of bipolar disorder, but several new drugs have been assessed for this indication. In a recent systematic review and network meta-analysis published in the Lancet Psychiatry in 2014, Miura and colleagues investigated the comparative efficacy and tolerability of available pharmacological treatment strategies for bipolar disorder. They searched Embase, Medline, PreMedline, PsycINFO, and the Cochrane Central Register of Controlled Trials for randomised controlled trials (until June 2013), that compared active treatments for bipolar disorder ...
This is an important advance in the development of a prototype for lab tests for bipolar disorder, and can serve as a model for developing tests in other complex disorders," said lead author Alexander B. Niculescu III, M.D., Ph.D., associate professor of psychiatry and medical neuroscience at the IU School of Medicine and director of INBRAIN at the IU Institute of Psychiatric Research.. Dr. Niculescu and colleagues used two different populations from large scale genetic studies and compared those individuals genes to a small panel of 56 genes implicated in bipolar disorder by their work, to predict who has a predisposition to the disease.. The analysis resulted in a genetic risk prediction score that indicates high or low potential for developing bipolar disorder. "The coupling of a high score with certain environmental factors may be a predictor, not a certainty, that the individual will develop bipolar disorder" said Dr. Niculescu, who also is a staff psychiatrist at the Indianapolis ...
Bipolar disorder (previously known as manic depression) is a psychiatric diagnostic category describing a class of mood disorders in which the person experiences clinical depression and/or mania, hypomania, and/or mixed states. The disorder can cause great distress among those afflicted and those living with them. Left untreated, bipolar disorder can be a disabling condition, with a high risk of death through suicide." "The difference between bipolar disorder and unipolar disorder (also called major depression) is that bipolar disorder involves both elevated and depressive mood states. The duration and intensity of mood states varies widely among people with BiPolar disorder. Fluctuating from one mood state to the next is called "cycling". Mood swings can cause impairment or improved functioning depending on their direction (up or down) and severity (mild to severe). There can be changes in ones energy level, sleep pattern, activity level, social rhythms and cognitive functioning. Some people ...
3 No exact cause has been found for bipolar disorder. It does run in families, so doctors say there is a genetic predisposition for it. In over eighty percent of those who have bipolar disorder, there is a family history of depression. Just because someone in the family has bipolar disorder doesnt mean another person in the family has to get it. Researchers believe that something biological or environmental combined with genetics triggers the disorder. So, for example, if a person has a genetic predisposition for it and that person experiences something stressful, bipolar disorder is more likely to occur ...
WPICs pediatric bipolar disorder clinic is featured in the New York Times Magazine Sept. 14 cover story on bipolar disorder in children.
Bipolar Disorder, Read about Bipolar Disorder symptoms, causes, diagnosis, and treatment. Also read Bipolar Disorder articles about how to live with Bipolar Disorder, and more.
Bipolar Disorder, Read about Bipolar Disorder symptoms, causes, diagnosis, and treatment. Also read Bipolar Disorder articles about how to live with Bipolar Disorder, and more.
Bipolar disorder is also known as manic-depressive illness. The condition is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day to day tasks. Scientists are still unsure of the exact cause of bipolar disorder but some possible causes include both genetics and the structure and function of the brain (NIH ...
Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states ...
Based on limited data, it is generally thought that pregnancy may protect against recurrence of major affective disorders or suicide. The postpartum period, however, is widely considered a high-risk period for recurrence of potentially severe and life-threatening episodes of major affective disorders. Use of antimanic agents (lithium, valproate, carbamazepine) is complicated because of the balance between some fetal teratogenic risk, the risk of untreated psychiatric illness during pregnancy and the early relapse of manic-depressive illness following cessation of medication. Viguera and associates studied whether pregnancy is associated with a greater or lesser risk of recurring mania or bipolar depression, and whether pregnant and nonpregnant women respond differently to treatment cessation.. Women with bipolar illness who discontinued lithium maintenance treatment were evaluated. Forty-two pregnant women were followed throughout pregnancy and for 24 weeks postpartum and compared with 59 ...
Objective: To assess classical psychometric properties of the Spanish versions of the Bech-Rafaelsens mania (MAS) and melancholia (MES) scales.. Method: Observational, prospective, and multicentric study in bipolar out-patients. Convergent validity was assessed against the Young Mania Rating Scale and the Montgomery-Åsberg Depression Rating Scale. Discriminant validity, reliability, and sensitivity to change, were also assessed.. Results: One hundred and thirteen bipolar patients with a manic episode and 102 bipolar patients with a depressive episode were included. Both the MAS and the MES showed appropriate convergent validity (r , 0.90), discriminant validity (P , 0.0001), internal consistency (Cronbachs alpha ,0.80), test-retest reliability [intraclass correlation coefficient (ICC) = 0.69 for the MAS and 0.94 for the MES], inter-rater reliability (ICC , 0.80), and sensitivity to change at 4 weeks since inception (P , 0.0001; within-group effect size ≥1.8).. Conclusion: The Spanish ...
Objectives: Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder. Read More ...
There are no existing longitudinal studies of inflammatory markers and atopic disorders in childhood and risk of hypomanic symptoms in adulthood. This study examined if childhood: (1) serum interleukin-6 (IL-6) and C-reactive protein (CRP); and (2) asthma and/or eczema are associated with features of hypomania in young adulthood. Participants in the Avon Longitudinal Study of Parents and Children, a prospective general population UK birth cohort, had non-fasting blood samples for IL-6 and CRP measurement at the age of 9 years (n = 4645), and parents answered a question about doctor-diagnosed atopic illness before the age of 10 years (n = 7809). These participants completed the Hypomania Checklist at age 22 years (n = 3361). After adjusting for age, sex, ethnicity, socio-economic status, past psychological and behavioural problems, body mass index and maternal postnatal depression, participants in the top third of IL-6 values at 9 years, compared with the bottom third, had an increased risk of ...
A new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) has identified specific genetic variations closely associated with increased susceptibility to bipolar disorder and other conditions. The discovery may provide a target for new therapies. In the new study, the researchers focused on a gene known as PDE10A, one of the many genes that has been linked to bipolar disorder, and the proteins this gene produces. These proteins help regulate intracellular levels of a messenger molecule called cAMP (cyclic adenosine monophosphate), which is involved in a variety of biological processes including learning and memory. "We began with the idea that behavioral changes in bipolar subjects might be due to these genetic variations in the cAMP messenger pathway," said Ron Davis, chair of TSRIs Department of Neuroscience. "We did find that this was the case and, indeed, that these variations were in one specific gene for the cAMP messenger pathway called PDE10A. The ...
To examine whether genes that predispose to schizophrenia also confer a predisposition to other psychiatric disorders such as bipolar affective disorder (BAD), we tested for linkage between the recently identified schizophrenia susceptibility locus D6S260 and the inheritance of BAD in 12 large Australian pedigrees. We found no evidence for linkage over a region of 12-27 cM from the D6S260 locus, depending on the model used. Our results therefore do not provide support for the continuum theory of psychosis.
The above describes a manic episode. In Bipolar Disorder, depression may also alternate with hypomanic episodes. These are not as long lasting or severe as a full manic episode. The high mood in hypomania lasts for at least 4 days and it does not cause interference with normal social or occupational functioning. hide ...
TY - JOUR. T1 - Impaired sustained attention and executive dysfunction. T2 - bipolar disorder versus depression-specific markers of affective disorders. AU - Maalouf, Fadi T. AU - Klein, Crystal. AU - Clark, Luke. AU - Sahakian, Barbara J. AU - Labarbara, Edmund J. AU - Versace, Amelia. AU - Hassel, Stefanie. AU - Almeida, Jorge R C. AU - Phillips, Mary L. N1 - © 2010, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/. PY - 2010/5. Y1 - 2010/5. N2 - Objective - To identify neurocognitive measures that could be used as objective markers of bipolar disorder. Methods - We examined executive function, sustained attention and short-term memory as neurocognitive domains in 18 participants with bipolar disorder in euthymic state (Beuth), 14 in depressed state (Bdep), 20 with unipolar depression (Udep) and 28 healthy control participants (HC). We conducted four-group comparisons followed by relevant ...
When to start aripiprazole therapy in patients with bipolar mania Kiran Kumar Sayyaparaju,1 Heinz Grunze,1 Kostas N Fountoulakis2 1Newcastle University, Institute of Neuroscience, Academic Psychiatry, Newcastle upon Tyne, UK; 23rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Aristotle University of Thessaloniki, Greece Abstract: Aripiprazole is a third generation atypical antipsychotic with compelling evidence as a highly effective treatment option in the management of acute manic and mixed episodes of bipolar I disorders. It has a unique mode of action, acting as a partial agonist at dopamine D2 and D3, and serotonin 5-HT1A; and exhibiting antagonistic action at the 5-HT2A and H1 receptors. Overall, it has a favorable safety and tolerability profile, with low potential for clinically significant weight gain and metabolic effects, especially compared to other well-established treatments. It also has a superior tolerability profile when used as maintenance treatment. Side
Bipolar disorder, or bipolar depression, may lead to early death. It is a mental condition characterized by alternating mania and depression, usually interspersed with normal mood. And, it also may include psychosis. Because of the alternating moods, bipolar disorder was previously called manic-depressive illness. The word "manic" means excessive activity, euphoric mood, and impaired judgement.. Bipolar disorder affects about 5.7 million adult Americans, and one in 5 people who have the condition commits suicide. Furthermore, the U.S. has the highest bipolar rate in the world.[1] Bipolar disorder is also the sixth leading cause of disability in the world. In addition, it results in a 9.2-year reduction in the expected life span.[2]. New (and very exciting) research demonstrates that bright-light therapy has a profound and positive influence on this disease.[3] The researchers conducted a 6-week program to investigate the value of bright light therapy at midday for bipolar depression. The study ...
For the study, which was supported by Allergan affiliate Forest Laboratories, adults with bipolar I disorder who were experiencing an acute manic or mixed episode were enrolled in a randomized, placebo-controlled trial consisting of an initial 12- to 16-week open-label period and a 26-week double-blind randomized withdrawal period. The target asenapine dosage was 10 mg twice-a-day in the open-label period but could be titrated down to 5 mg. After completing the open-label period, subjects meeting stabilization/stable-responder criteria (based on Young Mania Rating Scale [YMRS] and Montgomery-Åsberg Depression Rating Scale [MADRS] scores ≤12) were randomized to asenapine or placebo treatment in the double-blind period. ...
Porteous, D.J. and Evans, K.L. and Millar, J.K. and Pickard, B.S. and Thomson, P.A. and James, R. and MacGregor, S. and Wray, N.R. and Visscher, P.M. and Muir, W.J. and Blackwood, D.H. (2003) Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes. Cold Spring Harbor symposia on quantitative biology, 68. pp. 383-394. ISSN 1943-4456 Full text not available in this repository.Request a copy from the Strathclyde author ...
Unipolar and bipolar disorders are both mood disorders that feature depression; however, there is a significant difference between the two.Unipolar disorder is basically an episode of depression that lasts for at least two weeks. Its symptoms include a...
Abstract:. BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P,0.03) than in the control group. No significant association was ...
Treating bipolar disorder effectively involves a combination of psychotherapy, appropriate medications, support, and self-care. Several types of therapy may be used to treat bipolar disorder, and medications include antidepressants, mood stabilizers, and antipsychotics, which help to relieve symptoms of depression, minimize mania, and stabilize mood between episodes. With commitment to a treatment plan, support from family, and good self-care, bipolar disorder can be managed.
Twenty-eight markers, both simple sequence repeats (SSRs) and restriction fragment length polymorphisms (RFLPs), were genotyped on members of 2 large pedigrees (OOA, BIP167) segregating bipolar affective disorder. Using the multipoint program build
MDGuidelines is the most trusted source of disability guidelines, disability durations, and return to work information on bipolar affective disorder depressed.
Ozzy osbourne and bipolar disorder - What is bipolar disorder? Manic depressive. Bipolar disorder is a mood disorder which is characterized by abnormally high (manic) and abnormally low (depressive) episodes.
Bipolar disorder is a chronic mental illness that causes dramatic shifts in a persons mood, energy and ability to think clearly. People with bipolar have high and low moods, known as mania and depression, which differ from the typical ups and downs most people experience. If left untreated, the symptoms usually get worse. However, with a strong lifestyle that includes self-management and a good treatment plan, many people live well with the condition.. With mania, people may feel extremely irritable or euphoric. People living with bipolar may experience several extremes in the shape of agitation, sleeplessness and talkativeness or sadness and hopelessness. They may also have extreme pleasure-seeking or risk-taking behaviors.. Peoples symptoms and the severity of their mania or depression vary widely. Although bipolar disorder can occur at any point in life, the average age of onset is 25. Every year, 2.9% of the U.S. population is diagnosed with bipolar disorder, with nearly 83% of cases being ...