Global Perfusion Bioreactors Sales Market Report 2017 1 Perfusion Bioreactors Market Overview 1.1 Product Overview and Scope of Perfusion Bioreactors 1.2 Classification of Perfusion Bioreactors by Product Category 1.2.1 Global Perfusion Bioreactors Market Size (Sales) Comparison by Type (2012-2022) 1.2.2 Global Perfusion Bioreactors Market Size (Sales) Market Share by Type (Product Category) in 2016 1.2.3 Small Scale(50 Liters to 1,000 Liters) 1.2.4 Large Scale(>1,000 Liters) 1.3 Global Perfusion Bioreactors Market by Application/End Users 1.3.1 Global Perfusion Bioreactors Sales (Volume) and Market Share Comparison by Application (2012-2022) 1.3.2 Biopharmaceutical Companies 1.3.3 Biotechnology Companies 1.3.4 Others 1.4 Global Perfusion Bioreactors Market by Region 1.4.1 Global Perfusion Bioreactors Market Size (Value) Comparison by Region (2012-2022) 1.4.2 United States Perfusion Bioreactors Status and Prospect (2012-2022) 1.4.3 China Perfusion Bioreactors Status and Prospect (2012-2022) ...
The report on the Global Membrane Bioreactor Systems market offers complete data on the Membrane Bioreactor Systems market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the Membrane Bioreactor Systems market. The top contenders GE Water, Veolia Water Solutions & Technologies, Koch Membrane Systems, Hitachi Aqua-Tech Engineering, Mitsubishi Rayon, Wehrle Umwelt GmbH, Degremont(SUEZ), Kubota, United Envirotech, WesTech Engineering, Bio-Microbics, Ovivo, Aqua-Aerobic Systems, Evac, Toray, Evoqua Water Technologies, Beijing Grant Membrane Separation Equipment of the global Membrane Bioreactor Systems market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20111. The report also segments the global ...
Title:In Vitro Osteogenesis of Human Stem Cells by Using a Three-Dimensional Perfusion Bioreactor Culture System: A Review. VOLUME: 7 ISSUE: 1. Author(s):Gabriele Ceccarelli, Nora Bloise, Marco Vercellino, Rosalia Battaglia, Lucia Morgante, Maria Gabriella Cusella De Angelis, Marcello Imbriani and Livia Visai. Affiliation:Dep. of Molecular Medicine, University of Pavia, Viale Taramelli 3/B, 27100 Pavia, Italy.. Keywords:Biomaterials, extracellular matrix, induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSC), osteogenesis, perfusion bioreactor, scaffolds, tissue engineering. Abstract:Tissue engineering (by culturing cells on appropriate scaffolds, and using bioreactors to drive the correct bone structure formation) is an attractive alternative to bone grafting or implantation of bone substitutes. Osteogenesis is a biological process that involves many molecular intracellular pathways organized to optimize bone modeling. The use of bioreactor systems and especially the perfusion ...
Fixed thin film, gas/vapor phase bioreactors were assessed relative to their potential for the bioprocessing of methane, trichloroethylene (TCE), and p-xylene. Methanotrophic bacteria were used to process the methane and TCE while a xylene resistant strain of Pseudomonas putida was used to process the p-xylene. Comparisons between the gas phase bioreactors and conventional shaken cultures and sparged liquid bioreactors showed that the gas phase bioreactors offer advantages over the other two systems for the degradation of methane in air. Rates of methane removal with the gas phase bioreactors were 2.1 and 1.6 fold greater than those exhibited by the shaken cultures and sparged liquid bioreactors, respectively. The gas phase bioreactors were shown to have application for the removal of TCE vapors from air with a removal rate of approximately 9 μg TCE d-1 bioreactor-1. Xylene vapors were also scrubbed from air using gas phase bioreactors. At a feed rate of 140 μg of xylene min-1, approximately ...
TY - JOUR. T1 - Bioreactor design for protein enrichment of agricultural residues by solid state fermentation. AU - Robinson, T. AU - Singh - Nee Nigam, Poonam. PY - 2003/3. Y1 - 2003/3. N2 - This paper reviews bioreactor designs and their use for protein production under solid state fermentation (SSF) conditions using various agricultural by-products. The advantages and disadvantages of various bioreactors and their potential for scale-up are described. SSF is proposed as a suitable low-tech strategy for protein enrichment for animal feed by converting a previously low value substance into a more nutritionally valuable one. The use of various substrates and microorganisms for protein enrichment are also listed. (C) 2002 Elsevier Science B.V. All rights reserved.. AB - This paper reviews bioreactor designs and their use for protein production under solid state fermentation (SSF) conditions using various agricultural by-products. The advantages and disadvantages of various bioreactors and their ...
During the past decade, single-use bioreactors have become widely accepted as an alternative to conventional stainless steel or glass bioreactors for clinical manufacturing and process development. In the biopharmaceutical industry, glass bioreactors are used mainly for process development and optimization, but also scale-down models for process characterization. So it is of significant importance that such vessels replicate the design of production-scale bioreactors for both reusable and single-use applications. Stirred-tank bioreactors with 2-L, 5-L, and 10-L working volumes have proven to…. ...
The amblr® 250 modular bioreactor system is an expandable benchtop workstation, which offers a simple approach to process development for fermentation and cell culture.. Sartorius Stedim Biotech (SSB) introduced the ambr® 250 modular to offer bioprocess scientists access to advanced benchtop bioreactor technology for process development. This system combines a unique single-use bioreactor vessel and consists of a workstation with 2, 4, 6, or 8 single-use bioreactors, with a working volume range of 100mL to 250mL.. These mini bioreactors are based on the same stirred tank bioreactors in the well-established ambr® 250 high-throughput system and contain impellers suitable for fermentation or cell culture. They are also fully integrated with liquid reservoirs and syringe pumps, allowing rapid experimental set up and turn around, significantly increasing lab efficiency.. The system brings simplicity to the lab bench. By following three easy steps, a bioreactor and all required accessories can be ...
Biological treatment of dairy wastewater was investigated using a laboratory scale aerobic sequencing batch flexible fibre biofilm reactor (SBFFBR). The SBFFBR system was modified from a typical sequencing batch reactor system by using eight flexible fibre bundles with a very high specific surface area, which served as support for microorganisms. The reactor was operated under different influent chemical oxygen demand (COD) concentrations (610, 2041 and 4382 mg l-1) and constant hydraulic retention times of 1.6 days. The results have shown successful applicability of the SBFFBR system to treat this dairy wastewater. High COD removal efficiencies between 89.7 and 97% were achieved at average organic loading rates of 0.4 and 2.74 kg COD m-3 d-1, respectively ...
Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer rate. In this study, a Chinese hamster ovary cell line producing a recombinant antibody was cultivated in a 5L OSR and a 3L STR, both operated with or without pH control. Effects of bioreactor type and pH control on cell growth and metabolism and on recombinant protein production and glycosylation were determined. In pH-controlled bioreactors, the glucose consumption and lactate production rates were higher relative to cultures grown in bioreactors without pH control. The cell density and viability were higher in the OSRs than in the STRs, either with or without pH control. Volumetric recombinant antibody yields were not affected by the process conditions, and a glycan analysis of the antibody by mass spectrometry did not reveal major ...
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Membrane Bioreactor Systems Market - by Types [Hollow Fiber, Flat Sheet, Multi Tubular], Configuration [Internal (Submerged/Immersed) & External (Sidestream)] & Applications [Municipal & Industrial Wastewater Treatment] - Trends & Forecasts to 2017" new market research report added to ReportsnReports.com store.. Dallas, Texas (PRWEB) December 30, 2012 This report "Membrane Bioreactor (MBR) Systems Market, By Application (Municipal & Industrial), Type (Hollow Fiber, Flat Sheet & Multi Tubular) & Configuration (Submerged & Sidestream) - Global Trends & Forecasts to 2017" analyses the Membrane bioreactor (MBR) market by geography, applications, configurations, and types of MBR. By geography, the report is segmented into Asia-Pacific, Europe, North America, and Rest of the World. The MBR type segment included in this report is based on design of the membrane, i.e. hollow fiber, flat sheet, and multi tubular. The end-users of this technology are spread across various industries - food & beverage, ...
Woodchip bioreactors are recognized as an effective best management practice in the Iowa Nutrient Reduction Strategy. This edge-of-field practice intercepts and removes NO₃-N, thereby reducing the NO₃-N concentration in tile drainage before being discharged into surface water. Actual NO₃-N load reductions realized by woodchip bioreactors are impacted by bioreactor size, hydraulic retention time (H ...
TY - JOUR. T1 - Optimizing the medium perfusion rate in bone tissue engineering bioreactors. AU - Grayson, Warren L. AU - Marolt, Darja. AU - Bhumiratana, Sarindr. AU - Fröhlich, Mirjam. AU - Guo, X. Edward. AU - Vunjak-Novakovic, Gordana. PY - 2011/5. Y1 - 2011/5. N2 - There is a critical need to increase the size of bone grafts that can be cultured in vitro for use in regenerative medicine. Perfusion bioreactors have been used to improve the nutrient and gas transfer capabilities and reduce the size limitations inherent to static culture, as well as to modulate cellular responses by hydrodynamic shear. Our aim was to understand the effects of medium flow velocity on cellular phenotype and the formation of bone-like tissues in three-dimensional engineered constructs. We utilized custom-designed perfusion bioreactors to culture bone constructs for 5 weeks using a wide range of superficial flow velocities (80, 400, 800, 1,200, and 1,800μm/s), corresponding to estimated initial shear stresses ...
The worldwide Bioreactors Market is anticipated to generate revenues over USD 550 million by 2024. It will grow at a CAGR above 18% in the forecast period (2016-2024). The industry is driven by the demand for biologics and adoption of single-use bioreactors (SUBs) & hybrid bioreactors. Rising popularity of SUBs in pharmaceutical manufacturing companies is yet another key driver.. SUBs or disposable bioreactors contain disposable bags instead of cultural vessels. They face high demand from the medical sector. These reactors are adopted by pharmaceutical companies to manufacture drugs without any negotiations on their quality. These systems differ in view of flexibility and cultural medium. Commercial bioreactors include CellMarket Regular from Cellexus and HyClone SUB from Thermo Fisher Scientific.. Browse Details of Report @ https://www.hexaresearch.com/research-report/bioreactors-market. Low functional costs of SUBs and low maintenance required for them can propel market demand from 2016 to ...
The worldwide Bioreactors Market is anticipated to generate revenues over USD 550 million by 2024. It will grow at a CAGR above 18% in the forecast period (2016-2024). The industry is driven by the demand for biologics and adoption of single-use bioreactors (SUBs) & hybrid bioreactors. Rising popularity of SUBs in pharmaceutical manufacturing companies is yet another key driver.. SUBs or disposable bioreactors contain disposable bags instead of cultural vessels. They face high demand from the medical sector. These reactors are adopted by pharmaceutical companies to manufacture drugs without any negotiations on their quality. These systems differ in view of flexibility and cultural medium. Commercial bioreactors include CellMarket Regular from Cellexus and HyClone SUB from Thermo Fisher Scientific.. Browse Details of Report @ https://www.hexaresearch.com/research-report/bioreactors-market. Low functional costs of SUBs and low maintenance required for them can propel market demand from 2016 to ...
Reactor systems are provided for the catalytic conversion of liquid feedstocks to synthesis gases and other noncondensable gaseous products. The reactor systems include a heat exchange reactor configured to allow the liquid feedstock and gas product to flow concurrently in a downflow direction. The reactor systems are particularly useful for producing hydrogen and light hydrocarbons from biomass-derived oxygenated hydrocarbons using aqueous phase reforming. The generated gases may find used as a fuel source for energy generation via PEM fuel cells, solid-oxide fuel cells, internal combustion engines, or gas turbine gensets, or used in other chemical processes to produce additional products. The gaseous products may also be collected for later use or distribution.
The physical and biochemical characteristics of the biomass in three lab-scale sequencing batch reactors (SBR) treating a synthetic wastewater at a 20-day target solids retention time (SRT) were investigated. The synthetic wastewater feed contained biogenic compounds and 22 organic priming compounds, chosen to represent a wide variety of chemical structures with different N, P and S functional groups. At a two-day hydraulic retention time (HRT), the oxidation-reduction potential (ORP) cycled between -100 (anoxic) and 100 mV (aerobic) in the anoxic/aerobic SBR, while it remained in a range of 126+/-18 and 249+/-18 mV in the aerobic sequencing batch biofilm reactor (SBBR) and the aerobic SBR reactor, respectively. A granular activated sludge with excellent settleability (SVI=98+/-31 L mg(-1)) developed only in the anoxic/aerobic SBR, compared to a bulky sludge with poor settling characteristics in the aerobic SBR and SBBR. While all reactors had very good COD removal (|90%) and displayed nitrification,
Bioreactors are integral to development of high value products and reducing reliance on existing chemical based commodity processes. The design of bioreactors for large scale production is complex process. Hydrodynamic condition in bioreactor plays a very important role in process performance and it is very important to get detailed insight into hydrodynamics for successful scale-up. Experimental testing at lab and pilot scale is both time consuming and expensive and does not always help to understand the underlying influence of reactor hardware and operating protocols on process yields.. This webinar discusses how MixIT - An Enterprise Mixing Analysis Solutions developed by Tridiagonal Solutions helps the process engineers to get more insights into hydrodynamics in bioreactors using advanced CFD based analysis.. Case studies will be demonstrated involving scale-up and troubleshooting of the bioreactors.. Who Should Attend? ...
Cell culture process development requires the screening of large numbers of cell lines and process conditions. The development of miniature bioreactor systems has increased the throughput of such studies; however, there are limitations with their use. One important constraint is the limited number of offline samples that can be taken compared to those taken for monitoring cultures in large-scale bioreactors. The small volume of miniature bioreactor cultures (15 mL) is incompatible with the large sample volume (600 µL) required for bioanalysers routinely used. Spectroscopy technologies may be used to resolve this limitation. The purpose of this study was to compare the use of NIR, Raman, and 2D-fluorescence to measure multiple analytes simultaneously in volumes suitable for daily monitoring of a miniature bioreactor system. A novel design-of-experiment approach is described that utilizes previously analyzed cell culture supernatant to assess metabolite concentrations under various conditions ...
Myozyme Produced at the 2000 L Bioreactor Scale to Receive Accelerated Approval Myozyme Produced at the 2000 L Bioreactor Scale to Receive Accelerated Approval Date: November 17, 2008 New PDUFA Date Set for February 28, 2009 Genzyme Corporation (Nasdaq: GENZ) today announced that the FDA plans an Accelerated Approval f
Validation of a model for process development and scale-up of packed-bed solid-state bioreactors | Frans J. Weber; Jaap Oostra; Johannes Tramper; Arjen Rinzema | download | BookSC. Download books for free. Find books
Validation of a model for process development and scale-up of packed-bed solid-state bioreactors | Frans J. Weber; Jaap Oostra; Johannes Tramper; Arjen Rinzema | download | BookSC. Download books for free. Find books
This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types.. In order to take advantage of recent advances in stem cell culture, biomaterials, and tissue engineering techniques, Resodyn Corporation proposes to develop, design, fabricate, and test a multi-functional bioreactor platform system. As a starting point for this multi-functional system, Resodyn Corporation will use its highly scalable (50-1,500ml) and successful (>1x108 cells/ml) hypoxia perfusion bioreactor. The focus of the proposed work will be to design additional culture modules that can be plugged into an advanced platform system developed by Resodyn Corporation. Modules that allow the culture of cellular monolayers, encapsulated cells, ...
Organic matter is the dominant pool of reduced carbon in marine and freshwater systems. Mineralization of organic matter is largely attributed to complex and diverse microbial communities that mediate degradation and ultimately yield the terminal respiratory product, carbon dioxide (CO2). The factors that constrain the lability and degradation of organic matter remain unclear, but they involve a complex interplay between structural and chemical properties of the compounds, physical properties of the matrices, and the functional potential of the microorganisms that are present. To investigate these relationships, we developed a novel bioreactor system-called Isotopic Carbon Respirometer-Bioreactor (IsoCaRB)-that permits real-time monitoring of microbial CO2 production rates and collects sequential samples of this CO2 for off-line isotopic analyses (C-13, C-14). Application of this system to organic-rich sediments from Salt Pond, MA reveals that organic matter is oxidized both abiotically and ...
Tissue engineering is an emerging field with the aim to produce artificial organs and tissues for transplant treatments. Cultivating cells on scaffolds by means of bioreactors is a critical step to forming the organ or tissue substitutes prior to transplantation. Among various bioreactors, the perfusion bioreactor is known for its enhanced convection through the cell-scaffold constructs. The enhanced convection will significantly increase the mass transport and at the same time, will increase the shear stress acting on the cells and scaffolds. To manipulate the scaffold-based cell culture process, knowledge of the mass transport and fluid flow (featured by flow velocity and shear stress) in bioreactors is required. Due to the complicated microstructure and multiphase flow involved in this process, the development of models for capturing the aforementioned knowledge has proven to be a challenging task. In this research, the mass transport and fluid flow in scaffolds cultivated in perfusion ...
DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive data management. Configurable solutions address the unique requirements of microbial, phototrophic, mammalian and human cells, stem cell applications, as well as biofuel and biopolymer processes.. ...
Each bioreactor is equipped with a process stand for ensuring the automated fermentation, cleaning, sterilization, heating and cooling processes. Each bioreactor container and process stand is equipped with pneumatic elements, mixer, circulation pump and peristaltic pumps. The bioreactors have in-built рН, рО2, temperature, maximum liquid level, foam level and pressure sensors. All sensors and control elements are connected to a corresponding bioreactor control local system, where the local control is performed from a color touch screen display (with a 7" or 9.6"). In the given example, the bioreactor control systems have Siemens Simatic controllers.. Thus the local control of each particular bioreactor was ensured independently from the rest bioreactors. The central cascade control system (CCCS) ensured interconnection between different bioreactors and the CIP/SIP system, as well as with the computerized SCADA system. For this purpose a more powerful Siemens Simatic controller was used in ...
Fine bubble oxygen transfer efficiencies fluctuated throughout the study. A nitrifying aeration system, operated at an 8-day sludge age, exhibited significantly higher αF values compared with a nonnitrifying system operated at a 2-day sludge age. Differences in organic loading, over the range investigated (0.50 to 1.2 kg biochemical oxygen demand [BOD]5/m3·d), did not show an effect on fine bubble αF performance. At a short sludge age (2 days) and a high volumetric organic loading rate, a pilot system operated at a higher recycle rate (100% versus 33%) exhibited improved aF values. The addition of either an aerobic or an anoxic upstream biological selector (13-minute hydraulic retention time) improved ceramic diffuser oxygen transfer performance at high volumetric organic loading rates ...
http://www.marketsandmarkets.com/Market-Reports/membrane-bioreactor-market-484.html. This market research report categorizes the MBR into submarkets on the basis of types, configurations, and application sectors. The report covers all the major types of MBR, i.e. hollow fiber, flat sheet, and multi tubular. The membrane bioreactor system combines filtration technology with biological treatment for municipal and industrial waste water treatment and water reuse applications. The system incorporates reinforced hollow fiber, flat sheet or multi tubular membranes specifically designed to meet the requirements of wastewater treatment.. The report  defines and segments the global MBR demand market with analysis and forecasting of the global volume (000 cubic meter/day for main regions) and revenue ($million for all segments) for MBRs. The market is segmented and forecasted on the basis of major regions such as North America, Europe, Asia-Pacific, and Rest of the World. The key countries are ...
How is Sequencing Batch Biofilm Reactor abbreviated? SBBR stands for Sequencing Batch Biofilm Reactor. SBBR is defined as Sequencing Batch Biofilm Reactor somewhat frequently.
MarketResearchReports.Biz presents this most up-to-date research on Global Membrane Bioreactor Systems Market Professional Survey Report 2017 Description
McFetridge, P. S., Abe, K., Horrocks, M. and Chaudhuri, J. B., 2007. Vascular tissue engineering: Bioreactor design considerations for extended culture of primary human vascular smooth muscle cells. Asaio Journal, 53 Sep-Oct (5), pp. 623-630.. ...
DASGIP Parallel Bioreactor Systems for R&D and process development in both cell culture and microbiology allow for advanced bioprocess control and automation. Parallel processing, precise control of all relevant parameters, user-defined profiles and innumerable automation features result in accelerated and highly efficient process development. Our DASware software solutions support DoE, process historians and comprehensive data management. Configurable solutions address the unique requirements of microbial, phototrophic, mammalian and human cells, stem cell applications, as well as biofuel and biopolymer processes.. ...
This study investigated the use of biological powdered activated carbon (PAC) for the removal of natural organic matter (NOM) and ammonia from drinking water. The impact of solids retention time (SRT), hydraulic retention time (HRT), PAC diameter and PAC concentration on the process efficiency was evaluated. Five bioreactors were filled with a slurry using two PAC concentrations (5 or 25 g l−1), two PAC mean diameters (25 or 200 μm) and two SRTs (30 or 100-160 days). The bioreactors were operated during 161 days using post-ozonated water as influent. It was determined that the PAC concentration in the bioreactors was a key parameter for the improvement of biological removal. The higher PAC concentration (25 g l−1) was more efficient for the removal of ammonia, dissolved organic carbon (DOC) and biodegradable dissolved organic carbon (BDOC). Full nitrification was observed after 90 days in bioreactors with 25 g l− of PAC. The PAC diameter (25 vs. 200 μm) did not significantly influence ...
Anaerobic reactors with ferric iron addition have been experimentally demonstrated to be able to simultaneously improve sulfate reduction and organic matter degradation during sulfate-containing wastewater treatment. In this work, a mathematical model is developed to evaluate the impact of ferric iron addition on sulfate reduction and organic carbon removal as well as the volatile fatty acids (VFA) composition in anaerobic reactor. The model is successfully calibrated and validated using independent long-term experimental data sets from the anaerobic reactor with Fe (III) addition under different operational conditions. The model satisfactorily describes the sulfate reduction, organic carbon removal and VFA production. Results show Fe (III) addition induces the microbial reduction of Fe (III) by iron reducing bacteria (IRB), which significantly enhances sulfate reduction by sulfate reducing bacteria (SRB) and subsequently changes the VFA composition to acetate-dominating effluent. ...
Human mesenchymal stem cells (hMSC) are a promising cell source for the manufacturing of cell therapeutic or tissue engineered implants. In part A of this publication a fixed-bed bioreactor system based on non-porous borosilicate glass spheres and procedures for the automated expansion of hMSC with high yield and vitality has been introduced. Part B of this study deals with the modeling of the process in order to transfer the bioreactors system from the laboratory to the production scale. Relevant model parameters have been obtained by fitting them to the experimental data of hMSC-TERT cultivations in scales up to 300 cm3. Scale-up calculations were carried out exemplarily for a target cell number of twenty billion cells ...
The new Corning Mini Bioreactors are ideal for high throughput process optimization for suspension cell culture. Consisting of a 50mL centrifuge polyprene tube with a vented cap, Corning Mini Bioreactors are sterile, nonpyrogenic, RNase-/DNase-free and are suitable for cell line development, clone selection, media optimization and recombinant protein development.
Wood chip bioreactors are simple trenches that can be constructed on farms to clean the water that flows out of tile drains. Although the bioreactors are already a proven practice, more work remains to be done.
Described in this poster is how to convert existing glass benchtop bioreactors to single use bioreactors with minimal capital investment.
TY - JOUR. T1 - Effect of NaCl on nitrate removal from ion-exchange spent brine in the membrane biofilm reactor (MBfR). AU - Van Ginkel, Steven W.. AU - Kim, Bi O.. AU - Yang, Ziming. AU - Sittmann, Robby. AU - Sholin, Mark. AU - Micelli, Joe. AU - Rittmann, Bruce. PY - 2012/1/20. Y1 - 2012/1/20. N2 - The H 2-based membrane biofilm reactor was used to remove nitrate from synthetic ion-exchange brine at NaCl concentrations from ∼3 to 30 g/L. NaCl concentrations below 20 g/L did not affect the nitrate removal flux as long as potassium was available to generate osmotic tolerance for high sodium, the H 2 pressure was adequate, and membrane fouling was eliminated. Operating pHs of 7-8 and periodic citric acid washes controlled membrane fouling and enabled reactor operation for 650 days. At 30 psig H 2 and high nitrate loading rates of 15 to 80 g/m 2 d, nitrate removal fluxes ranged from 2.5 to ∼6 g/m 2 d, which are the highest fluxes observed when treating 30 g/L IX brine. However, percent ...
The following chapter summarizes principles of fluid dynamics in bioreactor design with a focus on mammalian cell-culture systems.
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In early spring, there is a need to treat large volumes of cool tile water containing high nitrate concentrations. However, lower nitrate removal rates in denitrifying woodchip bioreactors have been observed when hydraulic retention time (HRT) and water temperature are low. One potential approach to improve woodchip bioreactor performance is to provide an alternative and readily available energy source to the denitrifying microorganisms through electrical stimulation. Previous work has demonstrated the capability of bio-electrochemical reactors (BER) to remove a variety of water contaminants, including nitrate, with the presence of a soluble carbon source. The objective of this study was to evaluate the denitrification rate of electrically augmented woodchip bioreactors and conduct a simple TEA to understand the possibilities and limitations for full-scale BER implementation for treatment of agricultural drainage. Three duplicated up-flow column woodchip bioreactors were studied: two controls (non
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The alternating processes applied in membrane bioreactors for municipal wastewater treatment may be an attractive option to reduce the energy consumptions and optimize carbon and nitrogen removal. However, the knowledge of these systems is often based on empirical results so to discourage the plant operators for its adoption. This paper discusses and compares the empirical evidence coming from two different alternating membrane bioreactors, a demonstration and a full-scale one. The two plants treat two real municipal wastewaters, rather different for both C:N ratio and degree of biodegradability of the influent organics. Nine steady-state runs have been carried out in the demonstration plant, while a one whole year operation has been considered for the full-scale system. Combining the results of the two MBRs, it was found that the alternating process was able to adjust automatically and adequately the aeration of the biological reactor with a nitrogen loading rate in the range 0.05-0.18 kgN m?3 ...
This thesis evaluates the performance of a deammonification system designed as a two-step tech-nology consisting of an initial partial nitritation followed by an Anammox process. Operation of a technical-scale pilot plant at the Himmerfjärden Wastewater Treatment Plant (Grödinge, Swe-den) has been assessed. Oxygen Uptake Rate (OUR) to evaluate the respiration activity of nitrifi-ers in the system and batch tests to assess reaction rates have also been applied in the study. It was found that the total inorganic nitrogen elimination strongly depended on the nitrite-to-ammonium ratio in the influent to the Anammox reactor, which was correlated with the per-formance of the partial nitritation phase. Therefore, a control strategy for oxidation of ammo-nium to nitrite has been proposed. Controlled oxygen supply to the partial nitritation reactor is obligatory to obtain a proper pH drop indicating oxidation of ammonia to nitrite at the adequate ratio. A very high nitrogen removal efficiency (an ...
Article Extremely fast increase in the organic loading rate during the co-digestion of rapeseed oil and sewage sludge in a CSTR - characterization of granules formed due to CaO addition to maintain process stability. In a co-digestion system running ...
Stirred-tank bioreactors are gaining more and more importance in the industrial production of pharmaceutical products, biofuels and food. When compared with 2D-cultivation systems, bioreactors are easy to handle, and multiple bioreactors can be controlled in parallel without a considerable increase of workload. In stirred-tank bioreactors cells can be cultivated as free cells in solution, cell aggregates or on microcarriers in batch, fed-batch or continuous cultivation modes ...
The Eppendorf DASbox Mini Bioreactor System is a premium tool that helps streamlining process development. Its innovative design in blocks of four makes it an ideal tool for parallel processing and De
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