The objective of this article is to report our first experience of CT guided percutaneous thoracic biopsy and to demonstrate the accuracy and safety of this procedure. This was a retrospective study of 28 CT-Guided Percutaneous Needle Biopsies of the Chest performed on 24 patients between November 2014 and April 2015. Diagnosis was achieved in 18 patients (75%), negative results were found in 3 patients (12,5%). Biopsy was repeated in these cases with two positive results. Complications were seen in 7 patients (29%), Hemoptysis in 5 patients (20%), Pneumothorax in 1 patient (4,1%) and vaso-vagal shock in 1 patient (4,1%). CT Guided Percutaneous Needle Biopsy of the Chest is a safe, minimally invasive procedure with high sensitivity, specificity and accuracy for diagnosis of lung lesions.

Objective:To evaluate the diagnostic value and the safety of CT-guided percutaneous lung biopsy of lung nodules. Methods:Datas of 119 cases lung nodules who underwent CT-guided percutaneous lung biopsy were studied. The sensitivity with diagnositic accuracy and complications were analyzed. Results:There were total 84 case of malignant tumor and 35 cases of benign lesion.79 cases of malignant tumor and 35 cases with benign lesion were diagnosed by CT-guided purcutaneous lung biopsy. 5 cases were diagnosed through clinical observation or operatioa The diagnositic sensitivity and accuracy were 94. 0%(79/84) and 100% (35/35) respectively. False negative rate and false positive rate were 4.2% and 0% respectively. The overall accurate rate was 95. 8%(114/119). Incidence of post-biopsy pneumothorax, hymoptysis, thoracic cavity bleeding and cerebral infarction were 16. 0%(19/119), 20.2%(24/119), 1.7%(2/119) and 1.7%(2/119) respectively. Conclusion: CT-guided percutaneous lung biopsy is relatively safe and has

To evaluate the value of CT-guided percutaneous needle biopsy of bone in the diagnosis of lymphomas based on PET/CT results. A retrospective analysis of the records of all patients with percutaneous bone biopsies based on PET/CT results and a final diagnosis of lymphoma between January 2012 and August 2017 was performed. Thirty-one patients were included in this study. The success and complication rates were assessed. The mean age of the 31 patients was 46.6 ± 21.2 years, and there were 16 men and 15 women. A definite diagnosis and accurate histological subtype were obtained in 26 patients, for a success rate of 84%. The most common subtype was diffuse large B cell lymphoma (n = 18). The remaining subtypes included three cases of marginal-zone lymphoma, two cases of follicular lymphoma, one case of Hodgkins lymphoma, one case of peripheral T cell lymphoma, and one case of B cell lymphoblastic lymphoma. No serious complications occurred in any of the patients. CT-guided needle biopsy based on PET/CT

Background. Current recommendations for spinal tuberculosis (TB) not requiring open surgery include core needle biopsy to confirm TB and determine drug sensitivity. International figures show the positive culture yield from core needle biopsies is 50 - 83%. Objectives. To (i) assess the yield of percutaneous needle biopsies; (ii) identify factors that may lead to a negative result; and (iii) determine whether, TB being suspected, needle biopsy is justified. Methods. We conducted a multicentre retrospective review of 44 patients treated for suspected spinal TB between January 2009 and April 2012, who did not require open surgery. Data captured included demographics, relevant history, outcome of investigations and histopathological findings in patients. Results. The overall positive TB culture rate was 59%. Age, duration of symptoms, HIV and neurological status, erythrocyte sedimentation rate and core size had no statistical influence. Of the 7 patients receiving TB treatment at the time of biopsy, 3 were

Tissue sampling is a problematic issue for inflammatory breast carcinoma, and immediate evaluation following core needle biopsy is needed to evaluate specimen adequacy. We sought to determine if confocal fluorescence microscopy provides sufficient resolution to evaluate specimen adequacy by comparing invasive tumor cellularity estimated from standard histologic images to invasive tumor cellularity estimated from confocal images of breast core needle biopsy specimens. Grayscale confocal fluorescence images of breast core needle biopsy specimens were acquired following proflavine application. A breast-dedicated pathologist evaluated invasive tumor cellularity in histologic images with hematoxylin and eosin staining and in grayscale and false-colored confocal images of cores. Agreement between cellularity estimates was quantified using a kappa coefficient. 23 cores from 23 patients with suspected inflammatory breast carcinoma were imaged. Confocal images were acquired in an average of less than 2 ...

Percutaneous needle biopsy refers to the technique of acquiring sample cells or tissue by inserting a needle into the targeted area or organ in the...

Abstract. Background: The optimal treatment of flat epithelial atypia (FEA) found on breast core needle biopsy (CNB) is controversial. We performed a retrospective review of our institutional experience with FEA to determine if excisional biopsy may be deferred.. Methods: Surgical records from 2009 to 2012 were reviewed for FEA diagnosis. After exclusion for concomitant lesions, CNBs of pure FEA were classified using a previously agreed upon descriptor of focal versus prominent. Data was analyzed with the Fishers Exact and Student-t test as appropriate.. Results: Of 71 CNBs evaluated, pure FEA was identified on 27 CNBs. Final excisional biopsy was benign in 24 of 27 cases (88%) with associated ductal carcinoma in-situ (DCIS) in 3 of 27 cases (11%). Eighteen of 27 (67%) CNBs were classified as focal while 9 (33%) were described as prominent. Zero of the 18 focal patients had a malignancy compared to 3 of the 9 in the prominent group (0% vs 33%, p=0.02). Of the 27 pure FEA CNBs, 6 patients ...

Lung needle biopsy - MedHelps Lung needle biopsy Center for Information, Symptoms, Resources, Treatments and Tools for Lung needle biopsy. Find Lung needle biopsy information, treatments for Lung needle biopsy and Lung needle biopsy symptoms.

Lung needle biopsy culture - MedHelps Lung needle biopsy culture Center for Information, Symptoms, Resources, Treatments and Tools for Lung needle biopsy culture. Find Lung needle biopsy culture information, treatments for Lung needle biopsy culture and Lung needle biopsy culture symptoms.

Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. Is the best needle yet to come?

Percutaneous needle core biopsy may be the definitive procedure where important diagnostic and prognostic information in acute and persistent renal allograft dysfunction is normally obtained. the promise of improving diagnostic precision and developing fresh, processed molecular pathways for restorative treatment will also be offered. Intro Renal biopsy remains the platinum standard by which essential diagnostic and prognostic info is definitely acquired after kidney transplantation.1,2 Biopsy methodologies have been devised to assess the acceptability of an organ before transplantation and to assess and forecast renal allograft overall performance after implantation. Renal transplant biopsy samples are analyzed from the same traditional and modern techniques as are used to assess samples from native kidneys (Package 1). With this Review, we describe the practical part D-106669 of renal biopsy in the management of renal allograft recipients and spotlight the changes that take place in renal ...

Global Core Needle Biopsy Devices Market by Manufacturers, Types, Regions and Application & Forecast to 2025(Shopping-NewsWire.com, January 13, 2018 ) Global Core Needle Biopsy Devices Market report is replete with detailed analysis from a thorough research, especially on questions that border on

The optimum technique for biopsy assessment of the nature of a major salivary gland mass remains controversial. Fine needle aspiration cytology (FNAC) has been the traditional and popular choice, but sampling of cellular clusters is largely associated with high non-diagnostic and false-negative rates, even under optimised circumstances. Ultrasound-guided core biopsy (USCB) provides a core of tissue that allows preservation of tissue architecture and that can be histologically and immunohistochemically examined, thereby improving the chances of a meaningful diagnosis. Although relatively recently applied in the pre-operative investigation of salivary lesions, USCB shows higher levels of accuracy and reduced non-diagnostic rates when compared with FNAC, in addition to good patient tolerability. A degree of caution should, however, be exercised because of the potential for tumour seeding, and time delays inherent to histological processing are also unavoidable. Where available, USCB may be given preference

Price of a print issue: €25.00 AIM: The aim of this study is to compare the diagnostic accuracy in detecting axillary node metastases between preoperative ultrasound with percutaneous core biopsy or fine needle aspiration cytology, in patients with breast cancer. MATERIAL AND METHODS: All cases with newly diagnosed ipsilateral primary breast cancer that underwent axillary ultrasound guided biopsies in a 2 year period were reviewed and the biopsy outcome was compared to the final histopathology from sentinel lymph node biopsy or axillary node dissection. Comparison was also attempted in a subgroup including only patients who underwent one method and in a second subgroup of patients who had both techniques performed. RESULTS: Within the total population results are in favor of core biopsy which correlates statistically significantly with the final histology after excluding neoadjuvant related false negatives. Within the single modality subgroup results are again in favor of core biopsy which ...

Econintersect: Needle biopsies have been a common diagnostic technique for prostate cancer and there is now data that indicates the procedure may have more than incidental risk. Based on research in a news article from Bloomberg, there is a risk of mortality from needle biopsies. A study in Toronto has found that nine of 10,000 patients died from antibiotic resistant bacteria within a month of undergoing a needle biopsy. Extrapolating that result to the more than 1 million precedures per year in the U.S., the implication is that more than 900 deaths could be occurring annually.. Follow up:. From Bloomberg:. Studies emerging during the past year have uncovered that a small, yet growing percentage of those undergoing routine needle biopsy tests are becoming critically ill and dying from bacterial infections. Infectious complications including sepsis, the condition Greenstein had, from prostate biopsies have more than doubled in less than a decade, studies from three countries show. Nine out of ...

Needle biopsy is a way of determining whether a lung mass is cancerous or benign. Its accuracy was established by research in which patients underwent f

Core needle biopsies for lymphoma diagnosis seriously affect diagnostics, treatment development and research Core needle biopsies (CNBs) are widely used in clinical diagnostic labs to aid in the diagnosis of malignant lymphomas and in latter years their use is increasing. CNBs provide a rapid method for obtaining tumour material and may be beneficial when the affected lymph nodes are located deep in the abdominal cavity or mediastinum and surgical excisional biopsies may be difficult to perform. However, according to the Swedish Haematopathology Quality and Standardization Committee, CNBs are insufficient for lymphoma diagnostic purposes and the guidelines state that material from surgical excisional biopsies are mandatory in order to obtain a robust histopathological evaluation of the lymph node architecture, cellular composition and growth pattern. Surgical excision biopsies also ensure that adequate material is available if additional molecular analyses should be required and also to ...

Biopsy-the removal of cells or tissue for microscopic examination-has a long history in medicine. The first percutaneous needle biopsy of the liver was reported in 1923, and the technique developed into an invaluable diagnostic tool in many organ systems.. The development of computed tomography (CT), ultrasound and magnetic resonance imaging (MRI), allowed physicians to use advanced imaging guidance with biopsies. Imaging-guided percutaneous needle biopsies achieve greater precision in targeting lesions, resulting in high sensitivities and low complication rates.. For the study, researchers looked for biopsy trends in Medicare claims data from 1997 through 2008 for 10 anatomical regions. Biopsy procedures increased from 1,380 per 100,000 Medicare enrollees in 1997 to 1,945 biopsies in 2008, representing a compound annual growth rate of 3 percent. In 2008, 67 percent of all biopsies were performed percutaneously, compared to 59 percent in 1997.. We also found that the use of imaging guidance ...

Semantic Scholar extracted view of [Diagnostic challenges on needle core biopsies of breast tumors. Pre-test answers]. by Marie-Pierre Chenard

Prostate needle biopsy is a test to look for prostate cancer. During the test, a thin, hollow needle is used to take small samples of tissue from the prostate. The samples are then tested in a lab.

For instance, let us consider a 55 year old non-smoking woman who presents with a 10 mm spiculated nodule located in the right upper lobe. Her past medical history includes a mastectomy for breast cancer six years previously. From table 3 the pre-test probability of malignancy is 44%. A TNAB is performed and a diagnosis of malignancy is obtained, which corresponds from the meta-analysis to a likelihood ratio of 72. From the nomogram of Fagan the post-test probability of malignancy reaches more than 98%. Had the pathologist responded suspicious for malignancy the post-test probability would have been around 92%. On the other hand, if the pathologist had diagnosed a benign lesion without being more specific, the post-test probability of malignancy is 5%. Finally, had the pathologist reported a finding of hamartoma the post-test probability of malignancy would have been less than 1%.. We restricted this analysis to studies that met methodological criteria for assessing diagnostic ...

Other experts noted that needle biopsies should almost always be the preferred procedure.. The take-home message for women is that needle biopsy has surpassed surgical biopsy as the initial tool to diagnose breast cancer, says Richard Shapiro, M.D., at the NYU Cancer Institute in New York City. The majority of women almost always have a needle biopsy before requiring the surgical removal of any lesion.. There is also cost to consider: The study estimates that $37.2 million in health care expenditures could be saved if needle biopsies were always the procedure of choice.. This is an important study which shows overzealous excision of breast lesions where the diagnosis could be made through minimally invasive interventional methods, says Deborah Axelrod, M.D., at the NYU Cancer Institute. If they can be diagnosed without a trip to the operating room, then so much the better.EXT. Always talk with your health care provider to find out more information.. ...

Other experts noted that needle biopsies should almost always be the preferred procedure.. The take-home message for women is that needle biopsy has surpassed surgical biopsy as the initial tool to diagnose breast cancer, says Richard Shapiro, M.D., at the NYU Cancer Institute in New York City. The majority of women almost always have a needle biopsy before requiring the surgical removal of any lesion.. There is also cost to consider: The study estimates that $37.2 million in health care expenditures could be saved if needle biopsies were always the procedure of choice.. This is an important study which shows overzealous excision of breast lesions where the diagnosis could be made through minimally invasive interventional methods, says Deborah Axelrod, M.D., at the NYU Cancer Institute. If they can be diagnosed without a trip to the operating room, then so much the better.EXT. Always talk with your health care provider to find out more information.. ...

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We reviewed 101 consecutive biopsy specimens of nonpalpable breast lesions obtained by needle localization. Forty-six biopsies were done on outpatients under lo

The Acquire Pulmonary EBUS-FNB Device is designed to be used with EBUS scopes for fine needle biopsy (FNB) of submucosal and extramural lesions of the tracheobronchial tree and the gastrointestinal tract.

Doctors give unbiased, helpful information on indications, contra-indications, benefits, and complications: Dr. Gliksman on percutaneous liver biopsy procedure: The suspicious density, seen in x-ray but can not be felt , this area is located in two or more planes, marked, computer guided needle enters, at the marked site and takes biopsy, radio opaque, marker is placed for future reference, that biopsy was taken from correct location , then simple small dressing will be applied.

A core needle biopsy is performed to rule out cancer in an abnormal area of breast tissue. A thin, hollow needle is used to remove a small amount of tissue from the breast. At SJRA, we perform core needle biopsies using imaging technology. The radiologist or breast imaging specialist will locate the abnormal area of the breast using mammography, MRI, or ultrasound technology. The images help guide the biopsy equipment to the suspicious area of the breast - hence, the terms MRI-guided biopsy, ultrasound-guided biopsy, and stereotactic (mammography-guided) core needle biopsy. Core biopsies are minimally invasive procedures; therefore, the risk of developing any complication is very low. After the biopsy has been completed, a small metallic marker (called a clip) is placed at the biopsy site to mark the area for future imaging. Core biopsies can be performed at one of our comfortable Womens Centers in Voorhees and Turnersville. (Many other healthcare providers offer core needle biopsy only in ...

Learn more about Fine Needle Biopsy at LewisGale Regional Health System DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...

Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...

Learn more about Fine Needle Biopsy at St. Davids HealthCare DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...

Olympus has introduced PeriView FLEX needle, which will enable improved access to peripheral pulmonary lesions during transbronchial needle aspiration (TBNA) procedures that are conducted in the diagnosis of lung diseases. The device features Olympus FLEX-cut technology, an innovation leveraging a spiral pattern of laser cuts on the needle, for unprecedented flexibility. The flexibility of the needle is a major advantage as it does not limit articulation of the bronchoscope making it difficult to reach certain target locations.. Furthermore, the PeriView FLEX TBNA needle is the only TBNA needle that can be used with the Olympus 2.0 mm guide sheath. This smaller guide sheath provides an extension of the bronchoscopes working channel, which creates an extended reach and when combined with the PeriView FLEX, enables better access when compared to other TBNA needles on the market.. Currently, CT Guided needle aspiration, a form of transthoracic needle aspiration (TTNA) is the typical approach for ...

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(A) Bone marrow needle biopsy specimen, showing grade 3 fibrosis (H&E stain, ×100). (B) Reticulin staining showing grade 3 fibrosis (Reticulin stain, ×200

PurposeTo assess the scope and determining risk factors related to the development of pneumothorax throughout CT-guided biopsy of pulmonary lesions in coaxial and non-coaxial techniques and the outcome of its management.Materials and MethodsThe study included CT-guided percutaneous lung biopsies in 650 consecutive patients (407 males, 243 females; mean age 54.6 years, SD 5.2) from November 2008 to June 2013 in a retrospective design. Patients were classified according to lung biopsy technique into coaxial group (318 lesions) and non-coaxial group (332 lesions). Exclusion criteria for biopsy were lesions ,5 mm in diameter, uncorrectable coagulopathy, positive-pressure ventilation, severe respiratory compromise, pulmonary arterial hypertension, or refusal of the procedure. Risk factors related to the occurrence of pneumothorax were classified into: (a) Technical risk factors, (b) patient-related risk factors, and (c) lesion-associated risk factors. Radiological assessments were performed by two ...

Pleural needle biopsy with Abrams needle, which can be performed by all chest physicians, is a simple, safe and cheap method of obtaining tissue from pleura, but its diagnostic rate is between 7 % -72 %, ~ 50 %. Problems for Abrams needle are scattered tumoral involvement on pleura, blind performance, small tissue sampling, to tend to early and dense fibrosis and usually involvement of lower pleural surface and diaphragmatic pleura.. Pleural needle biopsy with Abrams needle, which can be performed by all chest physicians, if done with image guided and if this increase the diagnosis rate, the number of second procedure which is more expensive and hard will decrease.. The study aims the comparison of rigid thoracoscopy with CT-guided pleural needle biopsy by the diagnostic efficacy and safety in patients with pleural effusion.. It has been planned that a total of 120 patients accepted to the study who have pleural effusion at plain chest roentgenogram. All patients are being randomized after ...

How Often is a Breast Biopsy Positive?. In other countries where costs are restrictive for breast biopsy tests the detection of breast cancer tends to be later and positives can be as high as 80%, but in the USA where we have an early detection policy and are very proactive about checking for cancers even if there is a slim chance of them being there, only about 20% of biopsies are cancerous.. What is Involved in a Breast Biopsy?. So now that you have you breast biopsy booked in your next concern is will it be painful and will it leave a scar? It very much depends on the type of breast biopsy that your Doctor has recommended for you. There are three main types of breast biopsy procedures.. Fine Needle Aspiration Biopsies. A fine needle aspiration biopsy is carried out as you would imagine with a very fine needle attached to a syringe which extract a small amount of tissue or fluid from the area of the breast that your Doctor has concerns about. This method is usually chosen when the lump of ...

Percutaneous liver biopsy is a procedure to take a tiny sample (biopsy) of your liver tissue. Percutaneous (say per-kew-TAY-nee-us) means through the skin. The procedure is also called aspiration biopsy or fine-needle aspiration. The tissue sample is looked at under a microscope. Your doctor can look for infection or other liver problems.. You may have some pain where the biopsy needle entered your skin (the puncture site). You may also have pain in your shoulder. This is called referred pain. It is caused by pain travelling along a nerve near the biopsy site. The referred pain usually lasts less than 12 hours. You may have a small amount of bleeding from the puncture site.. You will need to take it easy at home for 1 or 2 days after the procedure. You will probably be able to return to work and most of your usual activities after that.. ...

A CT-guided biopsy is a procedure by which the physician uses a very thin needle and a syringe to withdraw a tissue or fluid specimen from an organ or suspected tumor mass. This video shows the CT guided lung biopsy procedure on a female patient who presented with history of dyspnea, cough and left sided chest pain. The national average cost of liver biopsy is roughly around $1,520 to $2,325. Cost-effectiveness of hydrogel plugs in CT-guided lung biopsies. Percutaneous image-guided musculoskeletal biopsy provides an accurate, rapid, and cost-effective method for helping clinicians diagnose benign and malignant musculoskeletal lesions. Other tests can suggest that cancer is present, but only a biopsy can make a definite diagnosis. Cost savings were assessed by using national Medicare reimbursement costs of +385 for US-guided core biopsy, +610 for stereotactic core biopsy, and +1,332 for needle localization and surgical biopsy. The mean adjusted direct cost saving per US-guided core biopsy was ...

TY - JOUR. T1 - Lobular neoplasia on core-needle biopsy - Clinical significance. AU - Arpino, Grazia. AU - Allred, D. Craig. AU - Mohsin, Syed Khalid. AU - Weiss, Heidi L.. AU - Conrow, David. AU - Elledge, Richard M.. PY - 2004/7/15. Y1 - 2004/7/15. N2 - BACKGROUND. Approximately 25% of all cases of atypical ductal hyperplasia (ADH) diagnosed on core biopsy of the breast are associated with ductal carcinoma in situ (DCIS) or invasive malignancy at the same site. As a result, surgical excision has become the standard of care for patients with ADH. In contrast, because data on the relation between breast malignancy and lobular neoplasia (LN) detected on core biopsy are limited, clinical management of patients with LN remains controversial. The goal of the current study was to determine the incidence of breast carcinoma at sites of core biopsy exhibiting LN compared with sites of core biopsy exhibiting ADH. METHODS. The results of 2053 core biopsies were reviewed to identify cases of LN and cases ...

Fine needle aspiration (FNA) or core needle biopsy. Your doctor may choose this type of biopsy if you have swollen lymph nodes in your neck or armpit. For FNA, the doctor uses a very thin, hollow needle. For a core needle biopsy, the doctor uses a slightly bigger needle. The needle is used to take a small sample of tissue from the lymph node. For tumors deeper in the body, ultrasound or CT scans may be used to help the doctor guide the needle into place. A needle biopsy may not remove enough tissue for the pathologist to see cancerous cells. Or the sample may also be too small to tell the type of lymphoma. Because of this, most doctors dont use a needle biopsy to try to diagnose Hodgkin lymphoma. But there are times when a needle biopsy may be helpful. If you have been diagnosed with Hodgkin lymphoma, your doctor may use this to see if swelling in another part of your body is also lymphoma.. ...

Core needle biopsy findings of a follicular neoplasm with a macrofollicular growth pattern. The images in the left column and the right column show the core nee

MPM Medical Supply offers a number of FNA needles used for fine needle aspiration including Chiba Needles, Franseen Needles, and Westcott Needles. Our high-quality aspiration needles can be used for fine needle biopsy procedures and are manufactured in the United States.

Learn more about Breast Needle Biopsy at Doctors Hospital of Augusta DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...

The pre-treatment blood sample and tumor biopsies will be the control for the post-PV-10 blood samples and resected tumor samples. Tumor core needle biopsies will be collected from the designated injected and uninjected lesions one week prior to intralesional PV-10 therapy. Biopsy samples will be fixed in formalin and embedded in paraffin for immunohistochemical (IHC) staining. On day 0, the injected lesion will be treated with up to 5 mL of PV-10. Seven to 14 days after intralesional PV-10 treatment, the injected and uninjected lesions will be resected. A portion of each tumor equivalent to a core needle biopsy specimen will be fixed in formalin and embedded in paraffin for IHC staining. Immune cell infiltration will be compared between untreated baseline lesions and post-treatment lesions (injected or uninjected) by a blinded pathologist at Moffitt Cancer Center. Measurement is the ordinal level of the T-cell infiltration into tumors with three levels: 0, no brisk, and brisk ...

Percutaneous Liver Biopsy On Cat ds The malic acid present in all fruits are an excellent sources of the bile passage nausea and t

Radiologists are performing an increasing share of biopsies across all anatomic regions, and there has been a shift away from invasive approaches and non-image-guided percutaneous approaches toward percutaneous needle biopsy and image-guided percutaneous biopsy over the past decade, found a study published online June 29 in Radiology.

Estrogen receptor (ER), progesterone receptor (PgR), HER2, and Ki67 have been increasingly evaluated by core needle biopsy (CNB) and are recommended for classifying breast cancer into molecular subtypes. However, the concordance rate between CNB and open excision biopsy (OEB) has not been well documented. Patients with paired CNB and OEB samples from Oct. 2009 to Feb. 2012 in Ruijin Hospital were included. ER, PgR, HER2, and Ki67 were determined by immunohistochemistry (IHC). Patients with HER2 IHC 2+ were further examined by FISH. Cutoff value for Ki67 high expression was 14%. Molecular subtypes were constructed as follows: Luminal A, Luminal B, Triple Negative, and HER2 positive. There were 298 invasive breast cancer patients analyzed. Concordance rates for ER, PgR, and HER2 were 93.6%, 85.9%, and 96.3%, respectively. Ki67 expression was slightly higher in OEB than in CNB samples (29.3% vs. 26.8%, P = 0.046). Good agreement (κ = 0.658) was demonstrated in evaluating molecular subtypes between CNB and

Results:. Although hemorrhage was rare, complicating 1.0% (95% CI, 0.9% to 1.2%) of biopsies, 17.8% (CI, 11.8% to 23.8%) of patients with hemorrhage required a blood transfusion. In contrast, the risk for any pneumothorax was 15.0% (CI, 14.0% to 16.0%), and 6.6% (CI, 6.0% to 7.2%) of all biopsies resulted in pneumothorax requiring a chest tube. Compared with patients without complications, those who experienced hemorrhage or pneumothorax requiring a chest tube had longer lengths of stay (P , 0.001) and were more likely to develop respiratory failure requiring mechanical ventilation (P = 0.020). Patients aged 60 to 69 years (as opposed to younger or older patients), smokers, and those with chronic obstructive pulmonary disease had higher risk for complications. ...