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TY - JOUR. T1 - Quantitative examination of mechanophysical tumor cell enrichment in fine-needle aspiration specimens. AU - Ernst, Linda M.. AU - Rimm, David L.. PY - 2002/10/25. Y1 - 2002/10/25. N2 - BACKGROUND. The advent of cDNA microarrays and other molecular technologies necessitates the acquisition of tumor cell-enriched material because nonmalignant cells often decrease the sensitivity of the assays. Fine-needle aspiration (FNA) specimens from carcinoma have long been noted to be enriched in malignant cells. The current study quantitated the relative representation of tumor versus nontumor cells in FNA specimens compared with tissue sections using breast carcinoma as a model. METHODS. Five patients who had undergone both a diagnostic FNA and a surgical excision for breast carcinoma between January and July of 1996 were selected. Five random cellular fields from representative slides of the FNA (using the ThinPrep preparation of the wash) and surgical excision specimens were photographed ...
TY - JOUR. T1 - Anaplastic thyroid cancer. T2 - Ultrasonographic findings and the role of ultrasonography-guided fine needle aspiration biopsy. AU - Suh, Hee Jung. AU - Moon, Hee Jung. AU - Kwak, Jin Young. AU - Choi, Ji Soo. AU - Kim, Eun Kyung. PY - 2013. Y1 - 2013. N2 - Purpose: To investigate the ultrasonographic (US) features of anaplastic thyroid cancer (ATC) and the diagnostic performance of US-guided fine needle aspiration biopsy (FNAB) therein. Materials and Methods: Eighteen cases of ATC diagnosed between January 2001 and May 2011 were included. FNAB was performed in all cases. Initial FNAB results were divided into three groups: 1) the cytological ATC group, cytological diagnosis of ATC; 2) the underestimated group, cytological diagnoses of malignancy other than ATC; and 3) the false negative group, cytological diagnoses of atypical, benign and non-diagnostic lesions. We retrospectively reviewed US findings and compared treatment modalities between each group. Results: Among the 18 ...
Evaluation of the effectivity of the new thyroid fine needle aspiration biopsy (FNAB) apparatus of which patented from Turkish Patent Institute.
The aim of this study was to compare the results of palpation-versus ultrasound-guided thyroid fine-needle aspiration (FNA) biopsies. Clinical data, cytology and histopathology results were retrospectively analyzed on all patients who underwent thyroid FNA biopsy in our outpatient endocrinology clinic between January 1998 and April 2003. The same investigators performed all thyroid FNAs (ASC) and cytological evaluations (KP). Subjects in the ultrasound-guided group were older, otherwise there were no differences in baseline characteristics (gender, thyroid function, the frequency of multinodular goiter, nodule diameter and nodule location) between groups. Cytology results in nodules aspirated by palpation (n = 202) versus ultrasound guidance (n = 184) were as follows: malignant 2.0% versus 2.7% (p = 0.74), benign 69.8% versus 79.9% (p = 0.02), indeterminate 1.0% versus 4.9% (p = 0.02), inadequate 27.2% versus 12.5% (p | 0.01). Malignant results were compared with Fishers exact test. Other cytology
Fine-needle aspiration biopsy of lymph nodes. Fine-needle aspiration biopsy (FNAB), when performed by trained operators, and for the correct indications, is a safe and minimally invasive procedure, with an excellent diagnostic ...
TY - JOUR. T1 - Complications of ultrasound-guided fine-needle biopsy of the spleen. T2 - Report on 110 patients and review of the literature. AU - Di Stasi, M.. AU - Buscarini, L.. AU - Cavanna, L.. AU - Rossi, S.. AU - Buscarini, E.. AU - Silva, M.. PY - 1996. Y1 - 1996. N2 - The data on 110 patients who underwent ultrasound-guided fine-needle biopsies of the spleen (either with focal lesions or with a homogeneous echo pattern) were reviewed. Aspiration needles were employed in 41% of the biopsies and cutting needles in 59%. All patients were assessed 24 h after the biopsy by clinical examination, abdominal ultrasound and a full blood count. Only one minor complication occurred, that of a spontaneously resolving subcapsular haematoma undetected at the assessment 24-h post-FNB, which was subsequently diagnosed 1 week post biopsy. Eight other similar series were found in the literature. In these series, five non-fatal complications were reported out of a total of 364 patients (morbidity rate ...
TY - JOUR. T1 - Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management. AU - Faulkner-Jones, Beverly E.. AU - Foster, William J.. AU - Harbour, J. William. AU - Smith, Morton E.. AU - Dávila, Rosa M.. PY - 2005/1/1. Y1 - 2005/1/1. N2 - Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96% with and 93% without adjunct IHC. The sensitivity and specificity of FNAB for ...
A total of 113 fine needle aspirates of the breast masses were evaluated in which the subsequent biopsy or mastectomy specimen were also available for histological examination. The age ranged from 16 to 80 years with a mean of 42 years. In benign conditions the mean age was 34.7 years while in malignant cases it was 48 years. The cytological diagnoses were compared with the histological results which revealed that the specificity and sensitivity of fine needle aspiration cytology in the palpable breast lesions was 86.1% and 89.2% respectively with a positive predictive value of 93% and efficiency of 88.2%. Similar statistics from other series in which the cytological results of breast lesions were compared with histological results, revealed almost same results which suggest that fine needle aspiration cytology is an effective and accurate technique for the diagnosis and management of palpable breast lumps.
Fingerprint Dive into the research topics of Ultrasound-guided fine-needle aspiration biopsy of internal mammary nodes: Technique and preliminary results in breast cancer patients. Together they form a unique fingerprint. ...
Fine needle aspiration cytology and flow cytometry immunophenotyping of non-Hodgkin lymphoma: can we do better?. Objective: To evaluate the diagnostic efficiency of fine needle aspiration cytology/flow cytometry (FNAC/FC) in the diagnosis and classification of non-Hodgkin lymphoma (NHL) in a series of 446 cases and to compare the results with those of previous experiences to evaluate whether there had been an improvement in FNAC/FC diagnostic accuracy.. Methods: FNAC/FC was used to analyse 446 cases of benign reactive hyperplasia (BRH), NHL and NHL relapse (rNHL) in 362 lymph nodes and 84 extranodal lesions. When a diagnosis of NHL was reached, a classification was attempted combining FC data and cytological features. Sensitivity, specificity and positive and negative predictive values (PPV and NPV) of FNAC/FC in the diagnosis and classification of NHL were calculated and compared with those available in the literature.. Results: FNAC/FC provided a diagnosis of NHL and rNHL in 245 cases and of ...
Fine needle aspiration cytology (FNAC) and open biopsy of same enlarged lymph nodes were performed in 59 patients with lymphadenopathy. When histopathological and cytological examinations were compared, an accuracy of 91.5% was achieved with FNAC in the cases of lymphadenopathy of various etiologies. Thus, fine needle aspiration cytology being reliable, safe, rapid and economical procedure, is useful as an outdoor diagnostic procedure for diagnosing lymphadenopathy of various etiologies.
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The study by Zevallos et al., aimed to determine if the increased thyroid cancer incidence observed corresponded with a similar increase in the use of diagnostic investigations. Thyroid ultrasound and fine needle aspiration. This was achieved by examining the Veterans Affairs health system records. The number of cases of thyroid cancer and the numbers of diagnostic investigations performed in the period between the years 2000 and 2012 were compared. At the commencement of the study in 2000, the incidence of thyroid cancer was 10.3 cases per 100,000 people. In comparison, at the studys conclusion in 2012, the incidence of thyroid cancer was 21.5 cases per 100,000 people.. As with the incidence of thyroid cancer during the study period, the use of ultrasound and fine needle aspiration biopsy also exhibited an increase. In 2000, the rate of thyroid ultrasound was 125.6 per 100,000 people, which had increased to 572.1 per 100,000 people in 2012. Similarly, in 2000 the rate of fine needle ...
South Korea has experienced rapid modernization both socially and economically, leading to the improved health status of South Koreans but an
SUMMARY: The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of thyroid cancer, 7 with mucosal squamous cell carcinoma, 1 with renal cell carcinoma, 1 with parotid acinic cell cancer, 1 with metastatic colon adenocarcinoma, and 2 with no history of cancer. Intraoperative transoral sonography was performed using a commercially available endovaginal transducer. A transoral sonography-guided fine-needle aspiration was performed with a 25-cm-long 20-ga Chiba needle through a needle guide attached to the transducer shaft. Cytopathologic results were categorized as malignant, benign, or nondiagnostic. Transoral sonography ...
Results The final diagnosis was adenocarcinoma in 156 patients (67%), neuroendocrine tumor in 27 (12%), lymphoma in 6 (3%), metastatic malignancy in 8 (4%), and benign etiologies in 35 (15%). CP was identified in 44/234 (19%) patients. The overall diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for EUS-FNA were 92.9%, 97.1%, 99.5%, 70.8%, and 93.5%, respectively. The sensitivity (80% vs. 95%, P=0.020) and accuracy (86% vs. 95%, P=0.043) were significantly lower in patients with CP compared to those without CP. ...
In a great majority of cases, uveal tumours are diagnosed and treated based solely upon clinical examination and ancillary diagnostic studies such as ultrasonography and angiography.1 In general, diagnostic fine needle aspiration biopsy (FNAB) is limited to situations presenting as a diagnostic dilemma such as differentiation between an amelanotic uveal melanoma and a metastatic uveal tumour.2-5 The other major indication for ophthalmic FNAB is for prognostication purposes of uveal melanoma being treated with radiation therapy.6. Most ophthalmic surgeons have used available needles without customisation ranging in size from 22 gauge (G) to 30G, with the 25G needle being the most commonly used.2 7 8 … ...
A fine needle aspiration biopsy (FNAB)) device was designed to utilize a steel spring located between the syringe and its plunger which exerts a constant negative pressure (auto-vacuum). In 43 rats inoculated with breast tumor cells the technique was compared with the standard procedure of FNAB (21 Sp1 and 22 Walker 256 carcinosarcoma). Malignant cells were cytologically confirmed in all cases. Sufficient material was obtained in 95% of FNAB by auto-vacuum system versus 86% by standard technique. The superior results obtained with the auto-vacuum system was seen for both soft and hard tumours ...
In this blog, Neighborhood Radiology Services in metro New York explain more about fine needle aspiration biopsy, including how long the procedure takes:
Learn all about the thyroid Fine Needle Aspiration Biopsy (FNAB) from preparing for the procedure to what to expect after it is finished.
Fine-needle aspiration biopsy (FNAB) of the breast is a minimally invasive yet maximally diagnostic method. However, the clinical use of FNAB has been questioned. The purpose of our study was to establish the overall value of FNAC in the diagnosis of breast lesions. After a review and quality assessment of 46 studies, sensitivity, specificity and other measures of accuracy of FNAB for evaluating breast lesions were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize overall accuracy. The sensitivity and specificity for the studies data (included unsatisfactory samples) and underestimation rate of unsatisfactory samples were also calculated. The summary estimates for FNAB in diagnosis of breast carcinoma were as follows (unsatisfactory samples was temporarily exluded): sensitivity, 0.927 (95% confidence interval [CI], 0.921 to 0.933); specificity, 0.948 (95% CI, 0.943 to 0.952); positive likelihood ratio, 25.72 (95% CI, 17.35 to 28.13); negative
TY - JOUR. T1 - Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential. AU - Gleeson, Ferga C.. AU - Kipp, Benjamin R.. AU - Kerr, Sarah E.. AU - Voss, Jesse S.. AU - Lazaridis, Konstantinos N.. AU - Katzka, David A.. AU - Levy, Michael J.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Determination of tumor genetic architecture based on tissue analysis yields important information on signaling pathways involved in cancer pathogenesis and plays a growing role in choosing the optimal medical management of malignancies. Specifically, the advent of next-generation sequencing has led to a rapidly evolving era of relatively inexpensive, high-throughput DNA sequencing of tumors. One such example is multiplexed tumor genotyping (ie, panel testing) of more than 2800 mutations across 50 commonly mutated cancer-associated genes. This resulting mutational landscape shows medically actionable pathogenic alterations to optimize ...
By Dr Rishu Agarwal, MD (Pathology)Fine needle aspiration cytology (FNAC) is a diagnostic procedure where a needle is inserted into your body, and a small amount of tissue is sucked out for examin
TY - JOUR. T1 - Fine-needle biopsy of chest lesions. AU - Samuelsson, L.. AU - Albrechtsson, U.. AU - Tylen, Ulf. PY - 1982. Y1 - 1982. UR - http://www.scopus.com/inward/record.url?scp=0020412864&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0020412864&partnerID=8YFLogxK. M3 - Article. C2 - 7178480. AN - SCOPUS:0020412864. VL - 22. SP - 493. EP - 496. JO - Der Radiologe. JF - Der Radiologe. SN - 0033-832X. IS - 11. ER - ...
By Liang-Che Tao. The target of this booklet is to proportion authors mixed 30 years event within the fine-needle aspiration biopsy analysis of organs underneath the diaphragm with normal pathologists. ranging from the fundamentals, this publication progresses to in-depth cytomorphologic research with histologic and immunohistochemical affirmation of particular entities. Cytohistological correlation is emphasised by utilizing composite photos from both resected tumor or the mobilephone block each time attainable. ...
HTGFN : An adjunct to cytologic examination of fine-needle aspiration specimens in athyrotic individuals treated for differentiated thyroid cancer, to confirm or exclude metastases in enlarged or ultrasonographically suspicious lymph nodes   This test is not useful for screening asymptomatic individuals for neoplastic disease.
This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provide
Read The coherence between fine needle aspiration cytology and histopathology of palpable neck nodes in lower lip carcinoma patients, European Journal of Plastic Surgery on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Optimizing the development of targeted agents in pancreatic cancer: Tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays Academic Article ...
To the editor: In their evaluation of fine-needle aspiration biopsies of lymph nodes in patients with the acquired immunodeficiency syndrome (AIDS)-related conditions, Bottles and colleagues (1) emphasize the usefulness of this method for diagnosing malignancy, Kaposi sarcoma, and mycobacterial infection. We report a case in which the diagnosis of disseminated cryptococcosis was made on the basis of a routine May-Grünwald-Giemsa-stained lymph node specimen from fine-needle aspiration biopsy.. A 33-year-old black patient from Angola had lost weight and had night sweats and fever. Physical examination showed cervical, nontender small lymph nodes (0.5 to 1 cm). Mild splenomegaly was present. ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
PURPOSE: To report on the heterogeneity of monosomy 3 in a fine needle aspiration biopsy obtained transsclerally from choroidal melanoma for prognosis. METHODS: All clinical records for patients who had been diagnosed with choroidal melanoma and underwent iodine-125 plaque brachytherapy with intraoperative transscleral fine needle aspiration biopsy from January 2005 to August 20, 2011, and who had a positive result for monosomy 3 according to fluorescence in situ hybridization as reported by clinical cytogenetics testing were collected. Patient age and sex, total number of cells evaluated and number of cells positive for monosomy 3, tumor size, and metastatic outcome were recorded for each patient. RESULTS: A positive result for monosomy 3 was reported in 93 patients who underwent transscleral fine needle aspiration biopsy. Two patients were lost to follow-up immediately post-operatively, and the remaining 91 patients were included in this study. The mean number of cells evaluated in the biopsy ...
To date several published series have documented the difficulty in diagnosing follicular patterned lesions of the thyroid in cytology preparations 513-15]. The histologic follow-up of cases diagnosed as follicular lesions of neoplasm includes hyperplastic/adenomatoid nodules, follicular adenoma, follicular carcinoma and follicular variant of papillary carcinoma 615]. An earlier study published by Schlinkert et al from Mayo clinic showed that only 12% cases diagnosed as suspicious for follicular neoplasm on FNA were malignant on histologic follow-up. Interestingly, 27% were papillary carcinomas (majority were follicular variant) 4. Tuttle et al reported malignancy rate of 21% in their series of 149 patients diagnosed as follicular neoplasm on cytology 8. In our previous study the malignancy rate was 31% in 122 patients diagnosed as follicular neoplasm and almost half of these cases were follicular variant of papillary carcinoma.. In view of these above-mentioned studies we retrospectively ...
Most of pancreatic masses are represented by neoplastic processes, primarily ductal adenocarcinoma and less frequently neuroendocrine tumor, lymphoma and metastasis. On the contrary, non neoplastic lesions are represented by chronic, autoimmune pancreatitis and cysts [1, 2]. Pancreatic cancer is the fourth and fifth most common cancer in men and women respectively [3]. Due to local invasion or distant metastasis, only 15-20% of patients are surgical candidates at presentation. Among them, the 5-year survival rate is only 10-15% [4]. About 70% of pancreatic cancers develop in the head while 10-20% in the body and tail [5]. In many cases, pancreatic cancer is diagnosed in the advanced stage of the disease and at this point the tumor cannot be submitted to surgical resection. In fact, at the moment of diagnosis, 52% patients show distant disease and 26% have regional spread [6]. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a rapid, safe, cost-effective and accurate technique to evaluate
Purpose To study cytomorphology and cytologic diagnostic criteria of bone malignant lymphoma(MLB) by fine needle aspiration cytology(FNAC). Methods To use multiform stainings to observe the cytologic samples and compared with histologic results of same patients to analyse the morphologic appearances. Results Of eight cases of bone non Hodgkins lymphoma, seven were accurately diagnosed by FNAC, they showed monotypic immatare lymphocytes in cytomorphology. Conclusion The cytologic result to diagnose MLB by FNAC is dependable. The diagnostic basis of cytomorphology is consistent with cytologic diagnostic criteria of lymphoma.
TY - JOUR. T1 - Use of monoclonal antibodies to human breast-tumor-associated antigens in the diagnosis of fine-needle aspirates of breast nodules. T2 - Results of a multicenter study. AU - Natali, P. G.. AU - Mottolese, M.. AU - Perrone Donnorso, R.. AU - Buffa, R.. AU - Bussolati, G.. AU - Coggi, G.. AU - Corradi, G.. AU - Coscia-Porrazzi, L.. AU - Ferretti, M.. AU - Rondanelli, E.. AU - Castagna, M.. AU - Vecchione, A.. AU - Siccardi, G. A.. PY - 1990. Y1 - 1990. N2 - Fine-needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre-surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% ...
Boland MR, Prichard RS;Daskalova I;Lowery AJ;Evoy D;Geraghty J;Rothwell J;Quinn CM;ODoherty A;McDermott EW (2015) Axillary nodal burden in primary breast cancer patients with positive pre-operative ultrasound guided fine needle aspiration cytology: management in the era of ACOSOG Z011. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 41 (4):559-565. [DOI] [Details] ...
TY - JOUR. T1 - Stability of DNA, RNA, cytomorphology, and immunoantigenicity in residual thinprep® specimens. AU - Kim, Younghye. AU - Choi, Kap Ro. AU - Chae, Moon Jung. AU - Shin, Bong Kyung. AU - Kim, Han Kyeom. AU - Kim, Aeree. AU - Kim, Baek hui. PY - 2013/11. Y1 - 2013/11. N2 - The aim of this study was to evaluate the quality of residual liquid-based preparation (LBP) sample after cytopathologic diagnosis. Cervical swab, body fluid, and thyroid fine-needle aspiration (FNA) samples preserved in ThinPrep PreservCyt® solution were tested. Samples kept frozen at -80 °C and stored at room temperature were tested 12 months after the initial sample collection. Gel electrophotography of GAPDH multiplex PCR, RNA integrity number (RIN) values obtained from Agilent bioanalyzer, cytomorphologic changes, and immunohistochemical staining (cytokeratin, thyroid transcription factor-1 (TTF-1), and D2-40) were used for the evaluation of sample quality. All available samples showed successful ...
1. Mukhopadhyay S, Katzenstein AL. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011 Jan; 35(1):15-25. 2. Tacha D, et al. A Six Antibody Panel for the Classification of Lung Adenocarcinoma versus Squamous Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2012 May; 20(3):201-7. 3. Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):415-20. 4. Khayyata S, et al. Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. Diagn Cytopathol. 2009 Mar; 37:178-83. 5. Terry J, et al. Optimal immunohistochemical markers for distinguishing lung adenocarcinomas from squamous cell carcinomas in small tumor samples. Am J Surg Pathol. 2010 Dec; ...
Here's what you should know regarding fine needle aspiration biopsies of thyroid nodules to diagnose or rule out thyroid cancer.
title:Fine Needle Aspiration Cytology of Neck Lesion- An Experience at Tertiary Care Hospital in Central Gujarat. Author:Chauhan Savitri, Darad Dimple, Dholakia Aditi. Keywords:Aspiration, Lymphnode, Histologically, FNAC. Type:Original Article. Abstract:Introduction: Fine needle aspiration cytology has become a rapid, cost effective investigative method for obtaining reliable tissue diagnosis especially for the sites like neck where considerable overlapping of various structures makes it difficult to reach to exact diagnosis. Objective: Present study was taken up to evaluate role of FNA in management and diagnosis of various neck lesions and to compare FNA with conventional biopsy for providing correct tissue diagnosis. Method: Total 641 cases of neck lesions were subjected to FNA and out of these, 71 were further subjected to conventional surgical biopsy and results were correlated histologically. FNACs were performed in outpatient department of a tertiary care hospital by 23-24 gauge needle ...
What is the effect of ultrasound-guided needle dye injection in localization of intraoperative tumors? Background: Locating and surgically excising non-palpable neck tumors in an accurate, efficient and safe manner, particularly in previously operated areas, can be a challenge. Preoperative imaging with computed tomography, magnetic resonance, positron emission tomography, or ultrasound-guided fine-needle aspiration biopsy are tools typically […]. ...
A 40-year-old Caucasian female presented with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1-month period. There was no personal or family history of malignancy or diabetes mellitus. On examination, she was jaundiced with pale mucous membranes and capillary glucose was 23.1 mmol/L. Initial investigations showed iron deficiency anaemia and obstructive pattern of liver function tests. HbA1c was diagnostic of diabetes mellitus at 79 mmol/mol. Malignancy was suspected and CT chest, abdomen and pelvis showed significant dilatation of intra- and extra-hepatic biliary tree including pancreatic duct, with periampullary 30 mm mass lesion projecting into lumen of duodenum. Enlarged nodes were seen around the superior mesenteric artery. This was confirmed on MRI liver. Fasting gut hormones were normal except for a mildly elevated somatostatin level. Chromogranin A was elevated at 78 pmol/L with normal chromogranin B. Duodenoscopy and biopsy showed possible tubovillous adenoma with ...
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UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Womens Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
PUBLICATIONS, RESEARCH PROJECTS, ACHIEVEMENTS & AWARDS. 1) Toshniwal H P, Chada P K. Evaluation of Male Infertility and Physiological Role of Zinc. International Journal of Scientific Research. March 2016, 5 (3): 44-46. ISSN No. 2277-8179. 2) Chada P K, Toshniwal H P. Evaluation of Glycated Haemoglobin and Risk of Microalbuminuria in Patient with type II Diabetes Mellitus International Journal of Scientific Research. May 2016, 5 (3): 73-76. ISSN No. 2277-8179. 3) Toshniwal H P, Chada P K. Evaluation of serum Iron and Copper status in Pregnant Women with Iron Deficiency Anaemia. Global Journal for Research Analysis. April 2016, 5 (3): 75-78. ISSN No. 2277-8160.. 4) Toshniwal H P, Chada P K. Study on Sensitivity and Specificity of Thyroid lesion on Fine Needle Aspiration Cytology: A Hospital Based Study Global Journal for Research Analysis. March 2016, 5 (3): 65-68. ISSN No. 2277-8160.. 5) Toshniwal S H, Toshniwal H P. Evaluation of Incidental Findings of tumour in Cholecystectomy cases in ...
Background and Aim: A recently carried out randomized controlled trial showed the benefit of a novel 20-G fine-needle biopsy (FNB) over a 25-G fine-needle aspiration (FNA) needle. The current study evaluated the reproducibility of these findings among expert academic and non-academic pathologists. Methods: This study was a side-study of the ASPRO (ASpiration versus PROcore) study. Five centers retrieved 74 (59%) consecutive FNB and 51 (41%) FNA samples from the ASPRO study according to randomization; 64 (51%) pancreatic and 61 (49%) lymph node specimens. Samples were re-reviewed by five expert academic and five non-academic pathologists and rated in terms of sample quality and diagnosis. Ratings were compared between needles, expert academic and non-academic pathologists, target lesions, and cytology versus histological specimens. Results: Besides a higher diagnostic accuracy, FNB also provided for a better agreement on diagnosing malignancy (ĸ = 0.59 vs ĸ = 0.76, P , 0.001) and classification ...
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click Selective Export button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
TY - JOUR. T1 - Predictive factors for inaccurate diagnosis of swollen lymph nodes in endoscopic ultrasound-guided fine needle aspiration. AU - Fujii, Yuki. AU - Kanno, Yoshihide. AU - Koshita, Shinsuke. AU - Ogawa, Takahisa. AU - Kusunose, Hiroaki. AU - Masu, Kaori. AU - Sakai, Toshitaka. AU - Yonamine, Keisuke. AU - Kawakami, Yujiro. AU - Murabayashi, Toji. AU - Kozakai, Fumisato. AU - Noda, Yutaka. AU - Okada, Hiroyuki. AU - Ito, Kei. N1 - Publisher Copyright: © 2019 Korean Society of Gastrointestinal Endoscopy.. PY - 2019. Y1 - 2019. N2 - Background/Aims: This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation. Methods: Eighty-three consecutive patients who underwent EUS-FNA for abdominal or mediastinal lymph nodes from January 2008 to June 2017 were included from a prospectively maintained EUS-FNA database and retrospectively reviewed. ...
TY - JOUR. T1 - Is pancreatitis a complication of endoscopic ultrasound guided fine needle aspiration of the pancreas?. AU - Gress, F.. AU - Ikenberry, S.. AU - Ciaccia, D.. AU - Kiel, J.. AU - Lehman, Glen. PY - 1997. Y1 - 1997. N2 - Introduction: Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the pancreas is increasingly being utilized to diagnose pancreatic masses. We have previously reported 2 cases of clinical pancreatitis following EUS guided FNA of the pancreas. Aim of Study: To determine the frequency of chemical and clinical pancreatitis following EUS guided FNA of the pancreas. Methods: All patients having EUS guided FNA biopsy of the pancreas were eligible. Exclusion criteria included: All patients with acute pancreatitis or having ERCP within 48 hours of the EUS FNA. Serum amylase and lipase levels were measured immediately prior to and 2 hours post EUS FNA. Patients were called 24-72 hours after FNA to follow up for increased pain, nausea, or vomiting suggesting ...
The aspiration smear revealed low cellularity with a clean background devoid of mucin. A few small collections of cuboidal epithelial cells with uniform round nuclei and pale cytoplasm were observed (Fig. 2A). The nuclear membranes were smooth, the chromatin was finely granular, and the nucleoli were small. The nuclear-cytoplasmic ratio was low. In a liquid-based preparation, two different cell populations were identified. The first population was composed of loose cell clusters of cuboidal cells with small, round nuclei and undefined cell borders (Fig. 2B). Sheets of atypical cells with disorderly arranged nuclei, occasional nuclear overlapping and nuclear grooves comprised the second cell population (Fig 2C). The cell borders were relatively well defined. These atypical cells were regarded as low-grade adenocarcinoma cells during the initial cytological diagnosis, but they were identified as gastric epithelial cells with degenerating atypia during retrospective review. Epithelial sheets with ...
TY - JOUR. T1 - Ultrasound-guided fine needle aspiration versus core needle biopsy. T2 - comparison of post-biopsy hematoma rates and risk factors. AU - Chae, In Hye. AU - Kim, Eun Kyung. AU - Moon, Hee Jung. AU - Yoon, Jung Hyun. AU - Park, Vivian Y.. AU - Kwak, Jin Young. N1 - Publisher Copyright: © 2017, Springer Science+Business Media New York.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - Purpose: To compare post-biopsy hematoma rates between ultrasound guided-fine needle aspiration and ultrasound guided-core needle biopsy, and to investigate risk factors for post-biopsy hematoma. Methods: A total of 5304 thyroid nodules which underwent ultrasound guided biopsy were included in this retrospective study. We compared clinical and US features between patients with and without post-biopsy hematoma. Associations between these features and post-biopsy hematoma were analyzed. Results: Post-biopsy hematoma rate was 0.8% (43/5121) for ultrasound guided-fine needle aspiration and 4.9% (9/183) for ultrasound ...
Castlemans disease (CD) is an uncommon lymphoproliferative disorder typically presenting as Mediastinal lymph node swelling. Clinical presentation can range from asymptomatic to generalised lymphadenopathy and hepatosplenomegaly. Two histological variants are hyaline vascular type and plasma cell type. Hyaline vascular type CD presents as unicentric mass mimicking various infectious and malignant causes of lymphadenopathy. Cytological features vary depending upon the extent of the lesion, thus, fine needle aspiration cytology (FNAC) is not always conclusive and histopathology is required to reach a definitive diagnosis. Here we present a case of unicentric castlemans disease (UCD) diagnosed on FNAC with histological correlation.. ...
Objectives To evaluate the effectiveness of fine-needle aspiration cytology (FNAC) & ultrasound scanning (US) in the diagnosis and management of solitary thyroid nodules.. Materials & Methods A retrospective study was carried out on 63 patients who were euthyroid and had a clinically palpable solitary thyroid nodule, who underwent either total or hemi-thyroidectomy, during a period of two years (January 2018 to December 2019) in the ENT unit of a tertiary care hospital in Sri Lanka. All patients with FNAC of Bethesda ≥5 underwent total thyroidectomy. Diagnostic hemi-thyroidectomy was performed only in patients with a FNAC of Bethesda ≤4, irrespective of US suspicious features.. Results Mean age was 46.9 years (±13.2). 53(84.1%) patients were females and 10 (15.9%) of them were male. 28(44.4%) patients had histologically proven malignancy while the other 35(55.6%) had benign histology. Sensitivity, specificity, positive predictive values and negative predictive values for FNAC and ultrasound ...
article{b4dd06dd-ccd1-448e-9856-ef0297979410, abstract = {,p,For preoperative localization of enlarged parathyroid glands, several imaging techniques have been used. In this study we demonstrate the feasibility of using ultrasonography with fine needle aspiration for parathyroid hormone assay as a preoperative localization procedure in 21 patients with primary hyperparathyroidism. A single adenoma was found in 18 patients while 3 patients had multiglandular disease. Ultrasonically guided fine needle biopsy was possible in 11 cases. In 8 of these aspirates, a high parathyroid hormone content was found. In all 8 cases the localization was confirmed at surgery. We conclude that the efficiency to preoperatively localize enlarged parathyroid glands is enhanced by fine needle aspiration.,/p,}, author = {Bergenfelz, A and Forsberg, L and Hederström, Esbjörn and Ahrén, B}, issn = {0284-1851}, keyword = {Adult,Aged,Aged, 80 and over,Biopsy, Needle,Female,Humans,Hyperparathyroidism,Male,Middle ...
Objective: We aimed to investigate the ultrasound (US) features and malignancy rates of thyroid nodules, below and above 1 centimeter diameter, according to fine needle aspiration biopsy (FNAB) results.. Materials and Methods: Total 157 nodular goiter patients, 60 patients nodules were below 1 cm and 97 patients nodules were above 1 cm, analyzed retrospectively. The nodules with pure cystic, peripheral calcification and inadequate cytological result were excluded. As a malignancy criterion at US, including hypo echoic pattern, solid structure, micro calcification features of nodule and not having peripheral halo feature of nodule were used. In statistical analyze, P,0.05 was accepted as significant.. Results: The malignancy or suspicions cytology rate was found 5% in nodules with below 1 cm, 17.5% in nodules with above 1 cm (total malignancy or suspicions cytology rate: 12.7%) and statistically it was not observed significant difference (P=0.548). The statistical significant differences was not ...
Fine-needle aspiration biopsy (FNAB) of the thyroid gland is the most cost-effective examination in the evaluation of thyroid nodules. The aim of this study was to present our experience from all patients who underwent thyroid FNA in the University Hospital of Ioannina, Greece, in the period 1993-2003, and its value in the diagnostic management of patients with thyroid nodules. FNA was performed in 900 patients of whom 753 were females and 147 males. The cases were classified according to diagnosis into five groups: benign/negative 628, primary carcinoma 28, metastatic carcinoma 5, suspicious/indeterminate 60 and non-diagnostic 179. Cytological findings were compared with histopathological findings and the statistical analysis in our data yielded the following results: sensitivity 92.1%, specificity 93.2%. These results are in accordance with the already published data in the international literature. In cases of differential diagnosis between adenomatoid hyperplasia and follicular neoplasia, ...
TY - JOUR. T1 - Fine needle aspiration cytology of a male breast carcinoma exhibiting neuroendocrine differentiation. T2 - Report of a case with immunohistochemical, flow cytometric and ultrastructural analysis. AU - Feczko, J. D.. AU - Rosales, R. N.. AU - Cramer, H. M.. AU - Goulet, R. J.. AU - Tao, L. C.. PY - 1995. Y1 - 1995. N2 - We present the cytologic, immunohistochemical, flow cytometric and ultrastructural findings of a case of invasive ductal carcinoma of the breast with features of neuroendocrine differentiation occurring in an 83-year-old male. Fine needle aspiration (FNA) cytology of the patients tumor demonstrated a markedly cellular specimen of discohesive tumor cells, present primarily singly, with occasional loose groups. The cells were relatively large, with pleomorphic, eccentrically placed, round to oval nuclei. The cytoplasm was abundant and contained prominent red granules (Papanicolaou stain) that were also argyrophilic. Immunohistochemical studies performed on the ...
Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. Is the best needle yet to come?
MRI depicts a 3 cm submucosal lesion on the anterior wall of the rectum, located 8.5 cm from the anal verge. The lesion has circumscribed smooth margins with intermediate signal intensity on T1-weighted images (Figure 1), low signal on T2-weighted images (Figure 2a, 2b) and low signal intensity on Diffusion Weighted Imaging with high b-value (Figure 3). Intravenous Gadolinium post contrast study revealed no contrast uptake (Figure 5). An endoscopic ultrasound-guided fine needle aspiration biopsy was suggested (Figure 6). There was also a small nodular focus, deep on the recto-uterine pouch, of high sinal intensity on T1-weighted fat-saturated images (Figure 4 ...
The optimum technique for biopsy assessment of the nature of a major salivary gland mass remains controversial. Fine needle aspiration cytology (FNAC) has been the traditional and popular choice, but sampling of cellular clusters is largely associated with high non-diagnostic and false-negative rates, even under optimised circumstances. Ultrasound-guided core biopsy (USCB) provides a core of tissue that allows preservation of tissue architecture and that can be histologically and immunohistochemically examined, thereby improving the chances of a meaningful diagnosis. Although relatively recently applied in the pre-operative investigation of salivary lesions, USCB shows higher levels of accuracy and reduced non-diagnostic rates when compared with FNAC, in addition to good patient tolerability. A degree of caution should, however, be exercised because of the potential for tumour seeding, and time delays inherent to histological processing are also unavoidable. Where available, USCB may be given preference
Indeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As approximately 25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a pre-operative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques. Addressed diagnostics include gene mutation analysis, microRNA, immunocytochemistry, ultrasonography, elastosonography, CT, sestamibi scintigraphy, FDG-PET and diffusion-weighted MRI.The best rule-out tests for malignancy were the Afirma® GEC and FDG-PET. The most accurate rule-in test was sole BRAF mutation analysis. No diagnostic had both near-perfect sensitivity and specificity, and ...
Before the 1980s, the application of diagnostic cytology in Taiwan was limited to exfoliative cytology, such as sputum, body fluid, and Pap test. The utilization of interventional cytology began with thyroid FNA. Prof. Tien-Chun Chang, an endocrinologist at National Taiwan University Hospital, is considered to be the pioneer of thyroid FNA in Taiwan. In 1979, he performed the first thyroid FNA on a patient with follicular thyroid carcinoma. After this initial attempt, which demonstrated promising diagnostic value, he began an on-site aspiration and cytologic diagnosis service at bedsides and in his thyroid clinic. Instead of using standard May-Grünwald-Giemsa staining, which usually takes less than 10 minutes, he applied Liu staining on cytologic smears, which produced similar staining quality for rapid diagnosis [3]. The Liu stain is a modified Romanowsky stain invented by Prof. Chen-Hui Liu in 1953 for hematologic smears. The entire staining procedure is simple and takes only 2 minutes [3]. ...
Price of a print issue: €25.00 AIM: The aim of this study is to compare the diagnostic accuracy in detecting axillary node metastases between preoperative ultrasound with percutaneous core biopsy or fine needle aspiration cytology, in patients with breast cancer. MATERIAL AND METHODS: All cases with newly diagnosed ipsilateral primary breast cancer that underwent axillary ultrasound guided biopsies in a 2 year period were reviewed and the biopsy outcome was compared to the final histopathology from sentinel lymph node biopsy or axillary node dissection. Comparison was also attempted in a subgroup including only patients who underwent one method and in a second subgroup of patients who had both techniques performed. RESULTS: Within the total population results are in favor of core biopsy which correlates statistically significantly with the final histology after excluding neoadjuvant related false negatives. Within the single modality subgroup results are again in favor of core biopsy which ...
TY - JOUR. T1 - Early detection of occult thyroid cancer metastases in small cervical lymph node by genetic analysis of fine-needle aspiration specimens. AU - Lee, M. T.. AU - Lin, S. Y.. AU - Yang, H. J.. AU - Lee, T. I.. AU - Lin, H. D.. AU - Tang, K. T.. PY - 2000. Y1 - 2000. UR - http://www.scopus.com/inward/record.url?scp=0033672041&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033672041&partnerID=8YFLogxK. M3 - Article. C2 - 11108495. AN - SCOPUS:0033672041. VL - 29. SP - 322. EP - 326. JO - Journal of Otolaryngology - Head and Neck Surgery. JF - Journal of Otolaryngology - Head and Neck Surgery. SN - 1916-0208. IS - 5. ER - ...
Background: Differentiating potentially malignant thyroid nodules among those undetermined by cytology avoid unnecessary surgical procedures. Aberrant DNA methylation is ubiquitous in human cancers, including thyroid tumors. Biomarkers based on methylation profiles have been successfully used to diagnose early stage malignancy in many human cancers.. Objective and hypotheses: To determine the genome-wide promoter methylation status of cytologically indeterminate thyroid nodules.. Methods: We obtained genomic DNA from frozen samples of three classical (CV PTC) and three follicular variant papillary (FV PTC), two follicular adenomas (FA) and three adenomatous goiter (AG) removed from 11 unrelated patients. The DNA methylation fraction was enriched using methyl-DNA immunoprecipitation and interrogated on Affymetrix human promoter 1.0 array. For control, DNA from normal thyroid tissue patients were also extracted and pooled in a single reaction. All array data analysis were performed using ...
Author: Prakash H MuddeGowda , Jyothi B Lingegowda , Shankar S Hiremath , Kishanprasad HL , Dr.Ramaswamy AS , Aravinda P. Category: Pathology. [Download PDF]. Abstract:. Background :. Fine needle aspiration cytology is a diagnostic tool used in the clinical workup of solitary thyroid nodules, to triage them into operative and non-operative lesions, as they have higher incidence of malignancy.. Methods :. Prospective study to find the utility of fine needle aspiration cytology (FNAC) in solitary thyroid nodules,. conducted at JJM Medical College, Davanagere. Fine needle aspiration specimens from 162 patients with solitary thyroid nodule were analyzed. In 70 patients histopathological study was made and cytohistopathological correlationwas done.. Results:. Out of 162 cases, female sex was found predominant (87.65%) and mean age of the patients was 35.67 yrs. Sensitivity, specificity and efficacy of the study for malignancy were 66.66%, 98.4% and 95.71% respectively.. Conclusions:. Although FNAC is ...
Background: Lymphadenopathy is a common clinical problem in our country among all age groups and in both sexes. In this study an attempt has been made to evaluate the clinical presentation and diagnosis of peripheral lymphadenopathy, which is commonly encountered in medical wards and diagnostic value of FNAC has been evaluated.. Methodology: This hospital-based descriptive study was done in thirty adult cases, of clinically apparent peripheral lymphadenopathy of at least more than two weeks of duration. Study was conducted over a period of 6 months from July, 2005 to December, 2005 in inpatients and outpatients of Rajshahi Medical College Hospital. After thorough examination, fine needle aspiration from several accessible enlarged lymph node groups were taken and sent for cytopathological examination and later biopsy of the significantly enlarged lymph node from the same anatomical region was performed and was sent for histopathological examination.. Results: Cytopathological study was ...
TY - JOUR. T1 - Comparison of differential diagnostic capabilities of 201Tl scintigraphy and fine-needle aspiration of thyroid nodules. AU - Okumura, Yoshihiro. AU - Takeda, Yoshihiro. AU - Sato, Shuhei. AU - Komatsu, Megumi. AU - Nakagawa, Tomio. AU - Akaki, Shiro. AU - Kuroda, Masahiro. AU - Joja, Ikuo. AU - Hiraki, Yoshio. PY - 1999/12/1. Y1 - 1999/12/1. N2 - We assessed the ability of 201Tl planar scintigraphy and fine-needle aspiration (FNA) biopsy to differentiate malignant from benign lesions by comparing the findings of these techniques with those of surgical histopathology for 107 patients with 109 thyroid nodules. Methods: 201Tl (74 MBq) was injected intravenously, and an early image and a delayed image were acquired after 10 and 120 min, respectively, for 10 min each. For 201Tl planar scintigraphy, accumulation of the tracer in the nodules was visually scored and the nodules were grouped. Group A showed high activity in both early and delayed images. Group B revealed high activity in ...
We present here a first-of-its-kind assay by which miRNA material is successfully extracted from routinely stained FNA cytology smears and classified as suspicious for malignancy by miRNA profiling or benign. In contrast to currently available tests,6 ,8 ,9 ,30 the test presented here does not require an additional FNA biopsy and can be performed on the same specimen as that initially used to categorise the sample as indeterminate. In addition, this test does not require specially designated preservation material, or unique shipment conditions. Instead, a single routinely prepared cytological slide, stained with Papanicolaou stain or Romanowsky type stains (Diff-Quik and Giemsa), can be used. The test does not require a large amount of cytological material, and the failure rate is quite low if there is minimal adequate cellularity, with 94% of the samples in the validation set being successfully processed.. The assays performance was evaluated based on a validation set composed of blinded, ...
These data suggest consideration of a more conservative approach for most patients with thyroid nodules that are cytologically indeterminate on fine-needle aspiration and benign according to gene-expression classifier results. (Funded by Veracyte.).
Of 8,936 endoscopic ultrasound examinations, 73 repeated procedures were identified, and 24 were excluded.. The 49 initial endoscopic ultrasound procedures were done in Indiana or another state, by one of 15 physicians in private practice, or at a teaching hospital.. The researchers performed an endoscopic ultrasound-guided fine-needle aspiration during an initial endoscopic ultrasound in 21 patients.. This method was not attempted in 14 patients.. The principle indication for a repeated endoscopic ultrasound in 35 patients was for an endoscopic ultrasound fine-needle aspiration after the initial tissue sampling was benign, nondiagnostic, or not done.. The researchers noted that a second endoscopic ultrasound had no clinical impact in 37% of patients.. The team found that in the remaining 63% of patients, a repeated endoscopic ultrasound provided a new or changed clinical diagnosis.. Dr DeWitts team commented, In this study, a repeated endoscopic ultrasound at a tertiary-referral center had a ...
Nodules in the thyroid are frequent. Preoperative investigations including fine-needle cytology and ultrasound cannot in all patients rule out malignancy. Thus, surgical excision for histopathologic examination is often needed. In this narrative review, we examine aspects of the surgical management of indeterminate thyroid nodules, using a comprehensive review of the available literature. The authors manually searched PubMed for relevant literature, including recently published guidelines. Hemithyroidectomy without lymph node dissection remains the recommended management in indeterminate thyroid nodules, i.e., the complete removal of one lobe of the thyroid, for indeterminate thyroid nodules, defined as nodules with fine-needle cytology fulfilling the criteria of Bethesda III or IV categories. At surgery, it is important to preserve the recurrent and superior laryngeal nerves, and intraoperative neuromonitoring is a useful adjunct. Recent data also suggest that parathyroid autofluorescent ...
© 2019 American Medical Association. All rights reserved. Importance: Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can be avoided for these patients if the nodules are reliably diagnosed as benign without surgery. Objective: To determine the diagnostic accuracy of a multigene classifier (GC) test (ThyroSeq v3) for cytologically indeterminate thyroid nodules. Design, Setting, and Participants: Prospective, blinded cohort study conducted at 10 medical centers, with 782 patients with 1013 nodules enrolled. Eligibility criteria were met in 256 patients with 286 nodules; central pathology review was performed on 274 nodules. Interventions: A total of 286 FNA samples from thyroid nodules underwent molecular analysis using the multigene GC (ThyroSeq v3). Main Outcomes and Measures: The primary outcome was diagnostic accuracy of the test for thyroid nodules with Bethesda III and IV cytology.
Accurate lymph node staging is essential for adequate prognostication and therapy planning in patients with non-small cell lung cancer (NSCLC). FDG-PET/CT is a sensitive tool for the detection of metastases, including non-palpable supraclavicular lymph node (SCLN) metastases. Histological proof of metastatic spread and mutation analysis is crucial for optimal staging and therapy. The aim of this study was to investigate the value of ultrasound-guided fine needle aspiration cytology (FNAC) and core biopsy (CB) of FDG active, non-palpable SCLNs in patients with suspicion for lung cancer. Twelve consecutive patients with suspected lung cancer and FDG-positive SCLN underwent FNAC (n = 11) and/or CB (n = 10) and were included and evaluated retrospectively in this study. Cytologic and/or histologic evaluation was performed to confirm initially suspected diagnosis (lung cancer), to confirm N3 stage, and to screen for driver mutations in lung adenocarcinoma. FNAC alone showed diagnostic success in 11/11 cases
Introduction: Thyroid nodules are a common clinical problem and Fine Needle Aspiration (FNA) is the principal method used for preoperative diagnosis. This study was designed to evaluate the diagnostic accuracy of FNA for detection of malignancy in thyroid nodules. Materials and Methods: In this retrospective study, 1016 patients with thyroid nodule ...
Recently Columbia oncologists diagnosed a toddler with acute myelogenous leukemia, and thanks to The Sohn Foundation for Precision Medicine, the entire family underwent genetic testing. Three of his siblings were found to have a gene linked to thyroid cancer. Their father was the carrier. Dr. Kuo found a suspicious thyroid nodule in his neck and with ultrasound-guided fine needle aspiration biopsy diagnosed medullary thyroid cancer, a rare and aggressive form of this disease. She operated the following week. With our early intervention, she says, there is a very good chance that the father has been completely cured and will remain cancer-free ...
Objectives Fine-needle aspiration (FNA) of thyroid lesions may result in infarction and diagnostic difficulties on subsequent thyroidectomy specimens. Next-generation sequencing (NGS) methods for detection of hallmark driver BRAF V600E mutations may help characterize such tumors in which histologic alterations preclude definitive tissue diagnosis. Methods Thyroidectomy specimens with both malignant FNA diagnoses and resultant infarction were identified from our institutional database. NGS methods were used to detect BRAF V600E mutations in the infarcted thyroid carcinomas. Results Nine thyroid carcinomas with infarction were characterized as BRAF-like papillary thyroid carcinoma based on molecular driver categorization and histologic diagnosis. BRAF V600E mutations were detected in the infarcted tissue in four (67%) of six lesions. Conclusions We demonstrate detection of hallmark BRAF V600E mutations by NGS within infarcted tissue of thyroid carcinomas after FNA. This suggests a potential ...
Several extrathoracic tumors metastasize to the mediastinum. Mediastinoscopy is the standard method to obtain tissue proof of mediastinal spread, but drawbacks are its invasiveness, requirement for general anesthesia and costs. Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is indicated in lung cancer staging guidelines as a minimally invasive alternative for surgical staging. The diagnostic values in patients with suspected mediastinal metastases and various (previous) extrathoracic malignancies were assessed. ...
2019 Wiley Periodicals, Inc.Background: In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods: Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study. Results: There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5. The indication for RAI treatment was Graves in 5 (18.6%), toxic nodular or multinodular goiter in 16 (69.2%), and unknown in 6 (22.2%) patients. A total of 48 thyroid nodules were evaluated with FNAB and cytological diagnosis were benign in 24 (50.0%), nondiagnostic in 15 (31.2%), atypia of undetermined significance in 5 (10.4%), suspicous for malignancy in 2 (4.2%), and malignant in 2 (4.2%) nodules. Thyroidectomy was performed in 10 patients, 5 were benign (50.0%), and 5 (50.0%) were malignant ...
Discussion: Adenomyoepithelioma was first reported by Hamperl in 1970 as an uncommon biphasic tumor composed of epithelial and myoepithelial cells (3). Adenomyoepitheliomas usually present as a single circumscribed mammary nodule. The fine needle aspiration findings in adenomyoepitheliomas have been described in only a few reports (1, 2, 4-11). It is important to recognize this entity as the radiologic and cytologic features can mimic malignancy. On cytology single enlarged atypical epithelial cells, presumed to be of myoepithelial origin due to staining with S-100 protein have been noted and led to the erroneous diagnosis of carcinoma (6). Only rarely can this diagnosis be made definitively on fine-needle aspiration biopsy (7). Histologic patterns include the tubular, lobulated and spindle cell variants (12). Biphasic pattern consists of tubules lined by cuboidal or columnar shaped epithelial cells surrounded by myoepithelial cell layer, Malignant adenomyoepitheliomas are usually characterized ...
MPM Medical Supply offers a number of FNA needles used for fine needle aspiration including Chiba Needles, Franseen Needles, and Westcott Needles. Our high-quality aspiration needles can be used for fine needle biopsy procedures and are manufactured in the United States.
OBJECTIVE: Fine-needle aspiration cytology is the risk stratification device for thyroid nodules, and ultrasound elastography isnt useful for the differential diagnosis of thyroid cancer routinely. value elevated from harmless to malignant nodules, and the current presence of Rolapitant autoimmune thyroid illnesses did not influence the outcomes (fine-needle aspiration cytology for the differential medical diagnosis of thyroid nodules, by using surgical pathology being a guide standard. Components AND Strategies Ethics acceptance and consent to participant The initial process from the scholarly research (XPH/CL/15/19 dated Sept 4, 2019) was accepted by the review panel of Xingtai Individuals Hospital. The analysis adheres to the rules from the Building up the Confirming of Observational Research in Epidemiology for cross-sectional research as well as the V2008 Declaration of Helsinki (Chinese language edition). All individuals provided up to date consent for medical diagnosis, radiological ...
The Acquire Pulmonary EBUS-FNB Device is designed to be used with EBUS scopes for fine needle biopsy (FNB) of submucosal and extramural lesions of the tracheobronchial tree and the gastrointestinal tract.
For years, thyroid nodules have been evaluated using fine needle aspiration (FNA). For most patients, this approach works reasonably well. But what about the roughly 30 percent of thyroid nodules characterized as having indeterminate cytology?. ...
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Study methods: To establish FNA biopsy requirements for gene expression-based subtype classification of NSCLC, patients with presumed newly diagnosed NSCLC, where radiographic studies and clinical description favor a probable diagnosis of NSCLC, will undergo FNA biopsy according to current standard techniques . For this part of the study, approximately 40 biopsies of confirmed NSCLC will be collected for analysis.. To define a fixed statistical model of histologic subtype prediction in NSCLC, we will prospectively collect 50 FNAs. These FNAs will represent Adenocarcinoma (AC) and Squamous Cell Carcinoma (SCC) cases at a ratio of approximately 1:1. Additional cases of not otherwise specified (NOS), should they be encountered, may also be collected for later analysis. FNA samples qualified based on cell number or ribonucleic acid (RNA) yield (depending on the findings of our primary objective)will be assayed on the QGS platform. ...
ObjectiveTo evaluate the diagnostic utility of image-guided fine-needle aspiration (FNA) in the head and neck.DesignAll image-guided FNAs of the head and neck p
Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed tomography (CT), 5-6% by magnetic resonance imaging (MRI) and 30-50% by positron emission tomography (PET). The final diagnosis depends on fine needle aspiration (FNA) findings and histopathology. The recent WHO classification (2017) is based on classic morphology, including assessment of invasion and nuclei. New entities are defined to designate tumours with doubtful invasion or controversial nuclear features. By immunohistochemistry, PC expresses HBME-1, TROP-2, CITED1 and CK19. Notably, PC can stain for CD20. MC is recognised by neuroendocrine differentiation. To distinguish FA vs. FC, evaluation of HBME-1, p27 and galectin
Conclusions.- Identifying factors that affect NGS success rates in cytology specimens is crucial for a better understanding of specimen adequacy requirements and for proper use of limited-volume tissue samples. In our practice, which uses direct smears as well as cell block sections, NGS success rates in core needle biopsy and fine-needle aspiration samples are comparable. The chance of successful testing is further increased by procuring concurrent fine-needle aspiration and core needle biopsy samples. The type of glass slides used for direct smears and the method of tissue extraction affect our DNA yield. Validating a DNA input for cytology samples that is lower than that recommended by the manufacturer has significantly increased our NGS success rate ...
This study will evaluate the technical feasibility of using fine needle aspiration (FNA) of liver tissue to obtain vaniprevir (MK-7009) liver pharmacokinetic (PK) data, working towards identifying a minimally invasive, reproducible platform to measure liver PK. The study will be done in 2 parts. In Part 1, participants will be randomized to one of five FNA/core needle biopsy (CNB) time-point collection sequences. In Part 2, participants will be randomized to one of two possible doses of vaniprevir and will be assigned to one of five FNA/CNB time-point collection sequences; participants in Part 2 will also receive background therapy with pegylated interferon alpha-2b (Peg-IFN alpha-2b) and ribavirin (RBV). The primary hypothesis is that there is a greater than 80% posterior probability that vaniprevir concentrations are successfully obtained at least 60% of the time from FNA liver samples collected at 2 of 3 specified timepoints ...
In this present study, we have shown that both RPFNA and DL are highly tolerable procedures (none of our subjects experienced bleeding, pain, or other complications with either procedure), and that once adequate samples are obtained, cytology was similar in DL and RPFNA samples. However, when the entire subject cohort was considered, the success rate of obtaining adequate samples was higher for the RPFNA versus the DL procedure.. Compared with long-term phase III breast cancer prevention trials, the advantage of short-term breast cancer prevention trials is that they do not require a large cohort of participants, are conducted over shorter periods of time, and are therefore more cost-effective. Cancer incidence is not the end point; instead, the aim of short-term prevention trials is to evaluate tissue surrogate end point biomarkers and the effect of potential preventive agents on such biomarkers over time (8). Besides, being used to monitor response to a preventive intervention, biological ...