TY - JOUR. T1 - Bioprosthetic mitral valve thrombosis complicating antiphospholipid antibody syndrome, successfully treated with thrombolysis. AU - Chamsi-Pasha, Mohammed A.. AU - Alyousef, Tareq. AU - Sayyed, Samer H. PY - 2014/1/1. Y1 - 2014/1/1. N2 - The incidence of bioprosthetic valve thrombosis and related embolic complications is extremely rare, obviating the need for long-term anticoagulation. As a result, experience in the diagnosis and treatment of bioprosthetic valve thrombosis is fairly limited. We report the first case of antiphospholipid antibody syndrome presenting as bioprosthetic mitral valve thrombosis, 15 months after valve replacement, and successfully treated with thrombolytic therapy. (Echocardiography 2014;31:E278-E281).. AB - The incidence of bioprosthetic valve thrombosis and related embolic complications is extremely rare, obviating the need for long-term anticoagulation. As a result, experience in the diagnosis and treatment of bioprosthetic valve thrombosis is fairly ...

TY - JOUR. T1 - Detection, localization, and quantitation of bioprosthetic mitral valve regurgitation. An in vitro two-dimensional color-Doppler flow-mapping study. AU - Vandenberg, B. F.. AU - Dellsperger, K. C.. AU - Chandran, K. B.. AU - Kerber, R. E.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1988. Y1 - 1988. N2 - The usefulness of two-dimensional color-Doppler flow-imaging (2D Doppler) in the detection, localization, and quantitation of bioprosthetic mitral valve regurgitation is uncertain. Mitral bioprostheses, before and after the creation of transvalvular (n = 33), paravalvular (n = 17), or combined (n = 23) defects, were mounted in a pulsed duplication system (flow rates, 2.5-6.5 l/min; pulse rate, 70 beats/min). An Aloka 880 2D Doppler system (Japan) was used to image the regurgitant jets in the simulated left atrial chamber, analogous to images obtained with transesophageal echocardiography. Jet area was corrected to an estimate of stroke volume: 2D ...

The perfect heart valve substitute has not yet been developed and matching the patient to existing options to optimize survival and reduce valve-related complications remains challenging. The choices for aortic valve replacement (AVR) are mechanical valves, bioprosthetic valves, and biological valves such as aortic valve homograft and the Ross procedure (pulmonary autograft). The latter is a complex operation because it transfers the patients own pulmonary valve into the aortic position and uses a biological valve to replace the pulmonary valve, transforming a single-valve disease into a 2-valve disease. These considerations are not important to most North American patients who undergo AVR because they are older and the durability of bioprosthetic valves in this age group is excellent (1,2). The risk of bioprosthetic valve failure 20 years after AVR is ,10% in patients 70 years of age and older (1,2). A report based on the Society of Thoracic Surgeons Database from January 1997 to December 2006 ...

The Edwards SAPIEN 3 and SAPIEN 3 Ultra Transcatheter Heart Valve system is indicated for relief of aortic stenosis in patients with symptomatic heart disease due to severe native calcific aortic stenosis who are judged by a Heart Team, including a cardiac surgeon, to be appropriate for the transcatheter heart valve replacement therapy.. The Edwards SAPIEN 3 and SAPIEN 3 Ultra Transcatheter Heart Valve system is indicated for patients with symptomatic heart disease due to failing (stenosed, insufficient, or combined) of a surgical or transcatheter bioprosthetic aortic valve or surgical bioprosthetic mitral valve who are judged by a heart team, including a cardiac surgeon, to be at high or greater risk for open surgical therapy (i.e., predicted risk of surgical mortality ≥ 8% at 30 days, based on the Society of Thoracic Surgeons (STS) risk score and other clinical co-morbidities unmeasured by the STS risk calculator).. Contraindications (Who should not use): ...

TY - JOUR. T1 - Do differences in early hemodynamic performance of current generation biologic aortic valves predict outcomes 1 year following surgery?. AU - Thalji, Nassir M.. AU - Suri, Rakesh M.. AU - Michelena, Hector I. AU - Greason, Kevin L.. AU - Dearani, Joseph A.. AU - Daly, Richard C.. AU - Joyce, Lyle D.. AU - Stulak, John M.. AU - Burkhart, Harold M.. AU - Li, Zhuo. AU - Schaff, Hartzell V. PY - 2015. Y1 - 2015. N2 - Objective: Small early postoperative hemodynamic differences were noted in a randomized comparison of 3 current-generation bioprosthetic aortic valves. Whether these differences persist and influence clinical outcomes 1 year following implantation is unknown. Methods: Three hundred adults with severe aortic stenosis undergoing valve replacement were randomized to receive the Epic (St Jude, St Paul, Minn) (n = 99), Magna (Edwards LifeSciences Inc, Irvine, Calif) (n = 100), or Mitroflow (Sorin Biomedica Spa, Saluggio, Italy) (n = 101) bioprostheses. Hemodynamic valve ...

No survival difference was observed between use of mechanical and bioprosthetic mitral valves in patients aged 50-69 years matched by propensity score (actuarial 15-year survival 57.5% [95% confidence interval (CI) 50.5-64.4%] vs. 59.9% [95% CI 54.8-65.0%], hazard ratio [HR] 0.95 [95% CI 0.79-1.15]), or in a subgroup analysis of age by decade. Among patients matched by propensity score, mechanical versus bioprosthetic mitral valve replacement was associated with higher 15-year incidence of stroke (14.0% [95% CI 9.5-18.6%] vs. 6.8% [95% CI 4.5-8.8%], HR 1.62 [95% CI 1.10-2.39]) and bleeding events (14.9% [95% CI 11.0-18.8%] vs. 9.0% [95% CI 6.4-11.5%], HR 1.50 [95% CI 1.05-2.16]), but a lower incidence of reoperation (5.0% [95% CI 3.1-6.9%] vs. 11.1% [95% CI 7.6-14.6%], HR 0.59 [95% CI 0.37-0.94]).. ...

Subclinical leaflet thrombosis occurred frequently in bioprosthetic aortic valves, more commonly in transcatheter than in surgical valves. Anticoagulation (both NOACs and warfarin), but not dual antiplatelet therapy, was effective in prevention or treatment of subclinical leaflet thrombosis. Subclinical leaflet thrombosis was associated with increased rates of TIAs and strokes or TIAs. Despite excellent outcomes after TAVR with the new-generation valves, prevention and treatment of subclinical leaflet thrombosis might offer a potential opportunity for further improvement in valve haemodynamics and clinical outcomes.. ...

A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

PhD Student Position in Mechanisms of Laminar-Turbulent Transition Past Bioprosthetic Aortic Valves The ARTORG Center for Biomedical Engineering Research is th

LivaNova PLC (NASDAQ:LIVN) a market-leading medical technology and innovation company, today announced that the advanced Perceval® Plus sutureless surgical aortic heart valve is now available for commercial release in Europe, having successfully completed a one-year limited launch with initial real-world clinical data gathering. Perceval Plus is positioned to become an essential component to any comprehensive heart program. Building on the clinically proven experience with Perceval®, this next-generation valve facilitates minimally invasive cardiac surgery (MICS) and makes sutureless aortic valve replacement available to a wide patient population. Key innovations with Perceval Plus include the anticalcification treatment, FREE, for valve durability, along with design changes intended to improve patient outcomes.

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Betsy Evans of Leeds General Infirmary in the United Kingdom presents a discussion on TAVI and surgery for prosthetic valve failure. She discusses the background of biological valve implant rate, rate of TAVI, and structural valve deterioration and treatment options. She focuses on two treatment techniques: redo AVR surgery and the TAVI valve-in-valve procedure.. ...

0067] In the embodiments described above relative to FIGS. 7 and 8, the tubular valve segments of stented valves of the invention have a ring of pericardial material that is thicker at one or both of its ends where the material is rolled or folded back on itself. This rolled-back material can overlap or cover the edge of the stent, such as to cover the edge of the stent wires, thereby making the edge or edges of the stented valve smoother. Alternatively, the material may be rolled or folded back in such a way that it does not cover the edge of the stent. For example, a folded portion of material can be positioned so that it is adjacent to an end of a stent and/or the folded portion of material can be positioned to face the interior opening or portion of the stent. In any case, the extra thickness of the material can be beneficial to prevent the stented valve from leaking around its perimeter when implanted in a patient. That is, the rolled or folded areas can help to stabilize the stented valve ...

The Edwards SAPIEN™ THV is a biological heart valve manufactured with treated bovine pericardial tissue that is mounted into a balloon expandable stainless steel open cell stent. The Edwards SAPIEN™ THV is available in two sizes (23 and 26mm) and is designed for transcatheter implantation in patients with regurgitant pulmonary valved conduit with or without stenosis. This device is commercially available and is used according the current IFU ...

Clinical introduction A man in his 50s presented with abscessed aortic valve methicillin-sensitive Staphylococcus aureus endocarditis, received intravenous antibiotics and underwent bioprosthetic aortic valve replacement with removal of all infected tissues. He returned 18 days later with severe dyspnoea, subjective fever and bilateral lower extremity oedema. Physical examination revealed tachypnoea and tachycardia without fever, prominent neck CV waves visible at 90°, left parasternal heave, 3/6 holosystolic murmur across the precordium, lung rales and severe peripheral oedema. C reactive protein was 211 mg/L (normal ,8 mg/L). Blood cultures were obtained. ECG showed sinus tachycardia and right axis deviation. Transthoracic echocardiogram (TTE) parasternal zoomed short-axis systolic frame (figure 1A, B), apical four-chamber systolic frame (figure 1C) and subcostal continuous wave (CW) Doppler (figure 1D), are shown. ...

For aortic root replacement in annuloaortic ectasia (AAE), an artificial prosthesis is commonly sutured to the aortic annulus (hemodynamic ventriculoaortic junction). We consecutively had 6 cases of aortic root replacement using anatomic ventriculoaortic junction suture. This anatomic ventriculoaortic junction suture is a simplified and practical method for aortic root replacement in the same way as using stentless bioprostheses or homografts ...

For the foreseeable future, bioprosthetic heart valves (BHV) fabricated from xenograft biomaterials will remain the dominant replacement prosthetic valve design...

Since the introduction of the sutureless Perceval® (Sorin Group, Saluggia, Italy) in Europe after CE mark in 2012, the sutureless approach is becoming more and more popular. Sutureless implantation in general is easy, fast and safe, but bears several potential pitfalls. This might result in inferior functional results affecting also clinical outcomes. In our center, more than 300 implant procedures have been performed up to date by mainly two senior surgeons. The technique is in the process of spreading to all surgeons performing aortic valve procedures. Proctored activities are completed at our and other institutions, and wetlab activities are conducted in collaboration with the manufacturers research and development laboratory. This article was written to give a step-by-step advice for surgeons who want to start a sutureless program or even have made limited experience with this approach wanting to reconfirm their technique. The focus is kept on surgical aspects regarding indication, ...

In terms of complications, Chhatriwalla said concerns have been raised about injuring the aorta or rupturing the annulus, though so far these have not been seen. Its also possible that BVF might increase the risk of thromboembolic events, though it might be hard to tease out the mechanism by which they occur, he said.. But there are ways to mitigate risks, Chhatriwalla stressed, such as by timing BVF differently.. Some operators favor doing BVF ahead of TAVR, he said. The thought behind this is that the size of the new TAVR valve is selected with the knowledge of whether or not the bioprosthetic valve can be fractured in the first place. So you fracture the valve first, you have success, and then put in maybe a larger-sized [TAVR] valve as a result, he explained.. But he and others at Saint Lukes prefer doing it after the TAVR device is implanted, Chhatriwalla added. Our mindset [is] were going to put in the valve size thats warranted, and were going to check the hemodynamics. Then if ...

The Carpentier-Edwards Bioprosthetic Valved Conduit (Model 4300) is made from a porcine (pig) aortic valve that has been preserved and mounted on a flexible frame. The flexible frame is composed of a corrosion resistant cobalt chromium metal alloy, silicone rubber, and is covered with polytetrafluoroethylene (PTFE) cloth. The valve is then mounted in a polyester tube. This device can be used to create an extra-cardiac pathway for blood flow in the pulmonic position. This conduit was introduced in the 1970s. ...

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AIM: Postoperative renal dysfunction after aortic valve replacement is a serious complication. To minimize its occurrence, risk factors have to be identified, and if possible eliminated. METHODS: Of 1000 consecutive patients, who underwent AVR, a file study was performed chi(2)nd logistic regression analysis were performed to study the effect of 24 preoperative, 7 peroperative and 7 postoperative factors on the occurrence of 30-day postoperative worsening of renal function. RESULTS: Fifty-three patients had a 30-day postoperative decrease of renal function. Nine of these patients died, which is significantly more than the mortality without this complication ( ...

Fatigue and Biodegradation in Engineered Tissue Devices: At present, about half of all heart valve replacements incorporate tissue-derived components: either transplanted human valves or so-called bioprostheses incorporating chemically-treated porcine or bovine tissues. While tissue valves offer more physiological blood flow and freedom for the patient from significant anti-clotting drugs, these valves typically fail in under 15 years. It has been estimated that more than 90% of all failed tissue valves show tears and perforations in the tissue leaflets; moreover, there is strong pathological evidence that host inflammatory cells are present at the margins of such damage. We are using a unique combination of mechanical fatigue simulation, proteolytic enzymes, and macrophage culture to look at the mechanisms by which engineered tissue valves fail. Weve shown a synergy between fatigue damage to collagen bundles and enzymatic cleavage (that is, the two acting together are more damaging than the ...

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Discover the best homework help resource for HUM SRVS at Allan Hancock College. Find HUM SRVS study guides, notes, and practice tests for Allan Hancock College.

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Turkeys Istanbul International Jazz Festival has landed a pair of firsts - Paul Simon will make his first appearance in the country when he closes the event next month (Jul11) and Herbie Hancock will debut his Tribute To Miles show.The...

The Hancock Inn in Hancock, New Hampshire, is one of the oldest inns in New England and home to the delicious Fox Tavern.  Whether you are skiing at Crotched Mountain or a history buff, this quaint bed and breakfast is a must-see. 

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Escucha las previsualizaciones de las canciones del álbum Orchestra - Single, y enterate de las ultimas novedades de tu artista Phil Hancock (2015) - 375 - freeiplus.com - Publicado: 2015-11-23 - ℗ 2015 Phil Hancock

TY - JOUR. T1 - Percutaneous implantation of a systemic-to-pulmonary shunt. AU - Butera, Gianfranco. AU - Piazza, Luciane. AU - Pomè, Giuseppe. AU - Chessa, Massimo. AU - Carminati, Mario. PY - 2006/11. Y1 - 2006/11. UR - http://www.scopus.com/inward/record.url?scp=33750976387&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33750976387&partnerID=8YFLogxK. U2 - 10.1161/CIRCULATIONAHA.106.624601. DO - 10.1161/CIRCULATIONAHA.106.624601. M3 - Article. C2 - 17101860. AN - SCOPUS:33750976387. VL - 114. JO - Circulation. JF - Circulation. SN - 0009-7322. IS - 20. ER - ...

Want an ad-free experience?Subscribe to Independent Premium. Inside Politics: All adults vaccinated by autumn, says Matt Hancock, Seven mass vaccination centres open across England, Populist propaganda is damaging the rollout of Covid vaccines, Unions urge public to back decent pay rise for NHS workers, Covid patients occupying more than 30,000 hospital beds in England, Increased restrictions would be tough - but the alternative is worse, Tony Blair advising Matt Hancock on pandemic response, Tougher lockdown not ruled out by Matt Hancock, UK ramps up vaccine rollout, targets every adult by autumn, Government pushes ahead with controversial rapid testing programme, UK to vaccinate out of pandemic by looking to local GPs, Inside Politics: Boris Johnson turns on completely wrong Trump, Covid vaccine will not stop hospitalisations, warns Hancock, Matt Hancock says he is not aiming for a zero-Covid Britain, Australian PM suggests UK cutting corners with Covid vaccine, Live: PM announces ...

METHODS AND RESULTS Between 1976 and February 1993, we performed 2871 operations for aortic stenosis. This study concerns 675 patients (278 men and 397 women) who were , or = 75 years old. Mean age was 78.5 +/- 3 years. Associated lesions were found in 226 patients. A bioprosthesis was implanted in 632 patients (93.6%). Concomitant surgical procedures were performed in 133 patients. Surgical mortality was 12.4% (84 deaths). A longitudinal analysis has been carried out over four successive time periods to evaluate population evolution during these 17 years. Statistical analysis was performed on 46 variables. Multivariate analysis found age (P , .0001), left ventricular failure (P , .0001), lack of sinus rhythm (P , .01), and emergency status (P , .02) to be presurgical independent predictive factors of mortality. ...

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Much has changed in the 21 years since Donna Zirkles physician found a lump during her annual breast exam.. The diagnostic mammogram that followed came back negative. Fortunately, Donnas doctor didnt stop there.. Bless my doctor, Donna said. She called me back and said, Donna, I know theres a lump there. Would you please go get an ultrasound? I actually thought about not doing that, but I trusted her. So, I went for the ultrasound, and I saw it on the screen-a little bitty thing.. Donna is one of a small number of patients - fewer than 10% - who receive a false negative from a mammogram. Her family physician sent her to see Cam Gabrielsen, then the breast surgeon at Hancock Health. Even Dr. Gabrielsen had his doubts about whether the 1.3cm tumor was cancerous.. I had a lumpectomy, Donna said. I hadnt signed off for a mastectomy, because they didnt think it was going to be cancer.. It was. And, three weeks later, she ended up having the mastectomy.. It turns out Donnas cancer was ...

Matt Hancock brings rare digital experience to running the NHS and social care systems, but can he overcome the legacy of past health service technology failures?

Dr. Michael Carter, MD is a Orthopedic Sports Medicine Surgery Specialist in Hancock, MI. He is affiliated with UP Health System - Portage. He is accepting new patients. Be sure to call ahead with Dr. Carter to book an appointment.

David F. DAlessandro was named president and chief operations officer of John Hancock Mutual Life Insurance. The promotion of the unconventional insurance executive signifies the industrys push to redefine itself.

Vanderbilt-Ingram Cancer Center and the Vanderbilt Institute of Chemical Biology developed out of the work of the Hancock Lab to merit national acclaim for cancer care and translational research that moves discovery from the lab to benefit patients. Today Vanderbilt-Ingram discoveries in cancer genetics are saving lives through precision cancer medicine that precisely targets therapy based on tumor characteristics for patients with melanoma and cancers of the lung, colon and breast. More potent cancer medicines are on the horizon as Vanderbilt-Ingram researchers identify promising candidates by designing novel molecules that effectively inhibit notoriously undruggable mutations found commonly in many cancers and drug-resistant tumors. This research could ultimately lead to treatment for many different types of cancer.. These groundbreaking innovations testify to the wonderful impact achieved by a remarkable family and friends working closely with Vanderbilt scientists. Their collective ...

IN THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF ALABAMA NORTHERN DIVISION DAVID HANCOCK, Plaintiff, v. JAMES HOOD, et al., Defendants. ) ) ) ) ) ) ) ) ) CIVIL ACTION 2:09-00026-KD-N JUDGMENT In accordance with the Order entered this date, it is ORDERED, ADJUDGED and DECREED that plaintiffs federal claims are DISMISSED with prejudice and that supplemental jurisdiction over the state-law claim under the Alabama Medical Liabilities Act, Ala. Code 6-5-484 (1975) asserted in Count Five of the Third Amended Complaint is hereby DECLINED and Count Five is DISMISSED without prejudice. Thus, it is ORDERED, ADJUDGED and DECREED that this action is DISMISSED in its entirety. DONE and ORDERED this 18th day of February, 2010. s/ Kristi K. DuBose KRISTI K. DuBOSE UNITED STATES DISTRICT JUDGE ...

278 ALLAN HANCOCK PACIFIC EXPEDITIONS VOL. 3 D. 138, dredged in 30 m., south of Tiburon Island, near Turners Island, Jan.; D. 347, in 22 m., off Punta Penasco, Feb. This species is distinct from Halymenia abyssicola of this paper in its thinner fronds (70-130 ft), outer cortex of only one or two layers of small cells, and absence of a thick surface jelly. Halymenia ? abyssicola sp. nov. Frondes planae membranaceae, minime 8 cm. latae, 300 [i crassae, marginibus integris, atro-roseae; glutino superficial! 25-35 p, crasso; corticibus stratis paucis cellularum minutarum dense aggregatarum, 5-7 u, diam. compositis; subcorticibus cellulis majoribus compositis; in medulla filamentis laxe intricatis et crabro con- junctiones stellae-formantes ostendentibus; (frondibus fructuosis nondum visis). Fronds plane, membranous, basal parts unknown, at least 8 cm. broad, with an entire margin, 300 ft thick, deep rose colored; cross section showing a thick surface jelly 25-35 ft thick, a cortical tissue of a few ...

I saw this piece by journalist and former Cameron-Levita speechwriter Ian Birrell, sometimes seen on the TV newspaper reviews: https://inews.co.uk/opinion/one-nation-toryism-has-died-a-brutal-death/ Ian Birrells view of Matt Hancock It would be a brave person who picked out the politician that has most debased themselves since the Brexit debacle exploded. But among the favourites in this crowded field…

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He was in Washington D.C. and inaugurated as Americas first president in 1789 when the Hancock Inn opened its doors. This room with a double bed and an inviting window seat alcove, overlooking the backyard, is a cozy retreat for a couple or single traveler. It is a perfect space for those who know how to travel light. There is a full bath with shower/tub combination.. ...

Five students from Allan Hancock College will travel to Louisville, Ky., to compete in the SkillsUSA National Championships, which aim to recognize st...

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