Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a computer model was developed to integrate the biophysical processes of oxidative phosphorylation and ROS generation. The model was calibrated with experimental data obtained from isolated rat heart mitochondria subjected to physiological conditions and workloads. Model simulations show that changes in the quinone pool redox state are responsible for the apparent inorganic phosphate activation of complex III. Model simulations predict that complex III is responsible for more ROS production during physiological working conditions relative to complex I. However, this relationship is reversed under pathological conditions. Finally, model analysis reveals how a highly reduced quinone pool caused by elevated levels of succinate is likely responsible for the ...

Proceedings of the symposium held on 11-14 September 2001 at the University of Sheffield, UK. This Symposium provided a snapshot of where we currently stand in exploiting SAR data to understand geophysical and biophysical processes. It identified important areas for future research, in terms of specific problems and general trends: in total, 80 papers were presented on Forestry, Agriculture and Land Cover, Hazards and DTM, Soils and Hydrology, Snow and Ice, Process Modelling.. ...

Proceedings of the symposium held on 11-14 September 2001 at the University of Sheffield, UK. This Symposium provided a snapshot of where we currently stand in exploiting SAR data to understand geophysical and biophysical processes. It identified important areas for future research, in terms of specific problems and general trends: in total, 80 papers were presented on Forestry, Agriculture and Land Cover, Hazards and DTM, Soils and Hydrology, Snow and Ice, Process Modelling.. ...

Two limitations of Dynamic clamp are entirely technical: it has to be fast and temporally consistent. The time required for reading the membrane potential and calculating the current to inject has to be faster than the fastest time constant in the real neuron. This becomes problematic when the model is computationally intensive (as with stochastic Markov models). With ever increasing computer processor speeds, the speed limitation of dynamic clamp is constantly being pushed back. The update interval of the dynamic clamp has to be reliable and reproducible. Modern operating systems (OS) such as Linux, Mac OS, and Windows suffer from the inability of a program running on the OS to be guaranteed a requested operation will be performed precisely when it is requested. Operating systems that can guarantee a request is performed within a well defined time window are Linux with the RTLinux kernel extension, LabView with the real time module, and DOS. A version of dynamic clamp developed by R. Pinto ...

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We aimed at providing an accurate estimation of human brain tissue electrical conductivity in clinico, using local, low-intensity pulsed stimulation. Methods: Using the quasi-static approximation of Maxwell equations, we derived an analytical model of the electric field generated by intracerebral stereotactic-EEG (SEEG) electrodes. We coupled this electric field model with a model of the electrode-electrolyte interface to provide an explicit, analytical expression of brain tissue conductivity based on the recorded brain tissue response to pulse stimulation. Results: We validated our biophysical model using: i) saline solutions calibrated in electrical conductivity, ii) rat brain tissue, and iii) electrophysiological data recorded in clinico from two epileptic patients during SEEG. Conclusion: This new model-based method offers a fast and reliable estimation of brain tissue electrical conductivity by accounting for contributions from the electrode-electrolyte interface. Significance: This method

Bioengineering research at the University of Vermont focuses on the application of quantitative engineering analysis to the study of biological systems.. The goal of this program is the development and implementation of computational and experimental engineering approaches for describing, analyzing, and predicting the behavior of complex biological systems at multiple scales. We consider scales ranging from the molecular level to the cell, tissue, organ, organism, and population levels. Emphasis is placed on understanding how biochemical, biomechanical and/or other biophysical processes interact and influence emergent properties at these different levels.. Areas of expertise in the program are:. Regenerative Medicine. Tissue ...

I am a Research Geologist for the USGS Southwest Biological Science Center (SBSC), and the Grand Canyon Monitoring and Research Center (GCMRC), in Flagstaff, Arizona. I am also an adjunct professor of the School of Earth and Sustainability (SES) at Northern Arizona University. Previously, I was a Mendenhall Fellow with the USGS Western Geographic Science Center located at the University of Arizona in Tucson. I have a Ph.D. in Engineering and Applied Science from the Geosciences Department at Idaho State University.. Overall, my research focus is on geomorphic and ecosystem processes and function of rivers and upland environments. I characterize and interpret physical and biological land surface change that occurs contemporarily at intra-annual to decadal time scales. I study changes that occur as a function of soil erosion and sediment transport. I also study biophysical processes that change the distribution and composition of vegetation. Many of the land surface changes I study are driven by ...

Research Interests: Understanding ecosystems and landscapes as complex systems in which human and biophysical processes are coupled across multiple scales of space and time; incorporating complexity into natural resource management approaches; regional-scale landscape modelling; social-ecological networks; agent and individual-based modelling approaches; landscape science and scenario building ...

The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

The early extraction is important, since the active ingredient is at the peak then.. • Only released after control of possible residues (e.g. antibiotics). • Freed from all undesired components (fat, large-molecule proteins, germs and others) by means of newly-developed gentle and biophysical processes. • After degreasing, it is de-caseinated. This way, a clearing of the liquid and a high active ingredient in the final product is secured. The ingredients are found in free form. That is a huge advantage since the gut absorbs the ingredients directly without the stomach having to digest it. The consequence: a clearly quicker perception of the desired effect.*. • During the entire production, chemical substances and preservatives are dispensed with so that the colostral agents remain bioactive. • Preservation according to pharmaceutical standards by cold sterile filtration. It is thus free of all kinds of germs.. • Turned into powder by a gentle lyophilisation process. The ...

apr/05_0213.htm.. Robert Burton, an English Anglican priest, was one of the most educated and widely read men of his day. He lived from 1577 to 1640 and is remembered for his influential treatise, The Anatomy of Melancholy (1). Lacking knowledge of biophysical processes, early healers sought to develop models for the treatment of mental illness. In Anatomy, Burton reviews this history as well as the most modern theories of the 17th century. At that time, melancholy referred to all mental diseases and conditions and was considered one of four humours that controlled body systems: blood was a hot, sweet, red humour; phlegm was cold and moist; and choler was hot and dry. But melancholy was cold and dry, thick, black, and sour, begotten of the more feculent part of nourishment, and purged from the spleen. In the 17th century, treatment for an imbalance in melancholy might have included teas, infusions, or broths of laurel, white hellebore, bugloss, marigold, or pennyroyal - or even bloodletting ...

TY - GEN. T1 - Robustness and optimality of decision making under norepinephrine modulation: A biophysical model of the neural substrate. AU - Eckhoff, Philip. AU - Wong-Lin, KongFatt. AU - Holmes, Philip. PY - 2008. Y1 - 2008. M3 - Conference contribution. BT - Unknown Host Publication. PB - Society for Neuroscience. T2 - Society for Neuroscience meeting 2008. Y2 - 1 January 2008. ER - ...

Rioting historically has been known to cause changes in individual cognition, with heightened emotionality, increased excitement and reduced reflective thought. A cross-disciplinary literature review hypothesises emotional states generate corresponding metabolic bio magnetic fields that radiate in patterns reflecting these emotional states. The oscillatory phase of these waves is advanced as being more significant than the power of signal, permitting stochastic effects to magnify signals by appropriating ambient noise. Possible transmission and detection structures in the body are discussed, induced paramagnetic sensitivity in crowd participants in a phase transition process is hypothesised, the effect may be proportional to crowd numbers. It is suspected that positive effects seen in Transcranial Magnetic Therapy used to treat depression may be operating on this mechanism, acting on natural receptors in the limbic system which also capture light and are implicated in mood transitions. A number of

New interdisciplinary facility will house 38 researchers across a variety of disciplines and aims to become a world-leading institute in understanding biophysical mechanisms of disease.

Zeng, Y. [曾毅博]. (2009). Biophysical characterization hpn-like (HPNL), a histidine- and glutamine-rich protein. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_ ...

Biophysics is the study of the interaction of biological systems and physical forces with which they come in contact. There are only 3 types of general forces that can affect biology and they effect it in only one of two ways. Beneficial/Nourishment or Detrimental/Poison. 1) Biochemical- Man made chemicals, foods,

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Representative input-output curves between P1 and P9.A: P2 cell: example individual traces and input-output curve in the VCN-LSO pathway. As shown here, input-o

INTRODUCTION: Multi-Regional Input-Output (MRIO) analysis makes it possible to track how an impact on any of the 546 IMPLAN Industries in...

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Purpose: : To search for proteins that bind to the Usher syndrome type 3 protein Clarin-1. Methods: : Yeast two-hybrid screening (Fields method) was performed using three baits representing the two predicted extra-cellular loops and the intracellular C-terminal region of the mouse Clarin-1 protein. The expression of recombinant GAL4-baits was confirmed by Western blot analysis. Suitability of the baits for screening was additionally confirmed by transactivation activity tests. Each of the baits was used to screen approximately 1.5 million mouse brain cDNAs for interaction. Isolated positive clones were identified by DNA sequencing and database searching. Potential interaction partners of Clarin-1 were subjected to the mating assay. Results: : Screening the mouse cDNA library with three GAL4-Clarin-1 baits identified 125 positive clones that potentially bind to Clarin-1. 110 of the clones were sequenced, of which 41 were in the correct reading frame with GAL4. Most of those 41 clones were ...

Capturing patient- or condition-specific intervertebral disk (IVD) properties in finite element models is outmost important in order to explore how biomechanical and biophysical processes may interact in spine diseases. However, disk degenerative changes are often modeled through equations similar to those employed for healthy organs, which might not be valid. As for the simulated effects of degenerative changes, they likely depend on specific disk geometries. Accordingly, we explored the ability of continuum tissue models to simulate disk degenerative changes. We further used the results in order to assess the interplay between these simulated changes and particular IVD morphologies, in relation to disk cell nutrition, a potentially important factor in disk tissue regulation. A protocol to derive patient-specific computational models from clinical images was applied to different spine specimens. In vitro, IVD creep tests were used to optimize poro-hyperelastic input material parameters in these ...

Dead sporulating female fly cadavers infected by the house fly-pathogenic fungus Entomophthora muscae are attractive to healthy male flies, which by their physical inspection may mechanically trigger spore release and by their movement create whirlwind airflows that covers them in infectious conidia. The fungal artillery of E. muscae protrudes outward from the fly cadaver, and consists of a plethora of micrometric stalks that each uses a liquid-based turgor pressure build-up to eject a jet of protoplasm and the initially attached spore. The biophysical processes that regulate the release and range of spores, however, are unknown. To study the physics of ejection, we design a biomimetic soft cannon that consists of a millimetric elastomeric barrel filled with fluid and plugged with a projectile. We precisely control the maximum pressure leading up to the ejection, and study the cannon efficiency as a function of its geometry and wall elasticity. In particular, we predict that ejection velocity ...

Downloadable (with restrictions)! Â Crop-livestock farms are complex systems. The interactions operating in such systems involve decisional, biophysical, structural, and environmental factors. Moreover, as farmers face a large range of management options, tools are needed to support their decision-making to enable them to reach production levels meeting their objectives and compatible with their human and physical resources, while controlling their effects on the environment. Gamede, a whole-dairy-farm model, has been developed to explore this complexity and to represent dynamically the effect of management decisions on biomass and nitrogen flows and on numerous sustainability indicators, such as milk and forage crop productivity, labour requirements, nitrogen balance, and nitrogen efficiency. This article describes the integration of six modules accounting for biophysical processes in a dairy farm (forage production; forage conditioning; herd demography; milk, excreta and animal biomass productions;

Joachim Frank (Columbia University, New York, USA) is a pioneer of single particle reconstruction, which is the most used reconstruction method for 3DEM structures in EMDB and EM entries in PDB. And also, he is a develper of Spider, which is one of the most famous software in this field, and is used for some EM Navigor data (e.g. map projection/slice images ...

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Biophysics or biological physics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems.

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Det medisinske fakultet (UiO), ble grunnlagt i 1814 og er landets eldste medisinske fakultet. Fakultetets kjernevirksomhet er forskning, utdanning og formidling til pasientens og samfunnets beste.

Congratulations to Tri Pham and Clemens Cabernard for their recent publication in iScience!. The paper describes cellular and biophysical mechanisms underlying the formation of sibling cell size asymmetry. They show how during cell division a big and small cell are being formed simultaneously. Sibling cell size asymmetry occurs across animal cells but the underlying mechanisms are not clear. Summary:. Metazoan cells can generate unequal sized sibling cells during cell division. This form of asymmetric cell division depends on spindle geometry and Myosin distribution, but the underlying mechanics are unclear. Here, we use atomic force microscopy and live cell imaging to elucidate the biophysical forces involved in the establishment of physical asymmetry in Drosophila neural stem cells. We show that initial apical cortical expansion is driven by hydrostatic pressure, peaking shortly after anaphase onset, and enabled by a relief of actomyosin contractile tension on the apical cell cortex. An ...

Our interests lie in constructing minimal systems, or artificial cells, as a tool to understand and recreate certain cellular behaviors. We are specifically interested in designing mechanically responsive systems that can optically or enzymatically report membrane stress in biological and polymeric environments. By using emerging engineering methods in material science and synthetic biology, we aim to construct macromolecular assemblies that can coordinate both membrane biophysical processes and RNA-regulated chemical processes in order to continuously sense and respond to designed stimuli for medicinal and technological applications. ...

Through the study of foundation sciences in biology, chemistry and landscape process, you will gain extensive knowledge of the interrelatedness of biophysical processes within Australian climate, water and landscape systems, soil formation, the physical, chemical and biological properties of soils and how these affect the availability of nutrients, toxins and plant growth.. You will examine physiological processes, using a whole plant approach, and their response to environmental variables and their dynamics in relation to canopies and root profiles. Using the interrelationships of plant genetics and environment, you will explore the role of plant breeding in sustainable cropping systems and devise integrated strategies for managing factors influencing plant and environmental health.. Soil and Plant Bioscience is available as a single or extended major ...

Background/Purpose: Circulating multipotential stromal cells (MSCs) also termed mesenchymal stem cells have previously been implicated in fibroblast mediated polyarticular joint destruction in rheumatoid arthritis (RA). We hypothesized that skeletal trauma (a biophysical process) rather than a biological basis related to RA may account for any MSC circulation. Methods: Deep (femoral) and matched peripheral (antecubital) vein blood was collected from 36 patients undergoing lower limb orthopaedic procedures. Peripheral blood was also taken from 15 early and 11 established RA patients as well as 12 healthy controls. Colony-forming unit-fibroblast (CFU-F) assays and cytometric phenotyping of cells were performed. Molecular characterisation of genes related to MSC function was undertaken in comparison to MSCs from iliac crest and femoral marrows, bone, periosteum, adipose tissue and dermal fibroblasts.. Results: 17/36 femoral vein samples contained CFU-Fs, but only 7/74 peripheral vein samples almost ...

Description: The Akosombo Dam on the Volta River in Ghana was built in 1963 to provide cheap energy to fuel industry and to accelerate the economic growth of the country. It provides hydroelectric power, enhanced fishing and water transportation upstream, and improved opportunities for irrigated farming, especially in the lower reaches, and their attendant economic multiplier effects. A few years after the construction of this major dam, a rapid expansion of industrialization took place in Ghana. This brought about an exponential increase in demand for more electrical power. This led to the construction of a smaller dam at Akuse, downstream of the Akosomho Dam in 1981 and the formation of a headpond at Kpong. The impoundment of the river at the two sites (Akosombo and Kpong) caused an alteration in the existing ecological and biophysical processes in the river basin, including a slowing of the flow of the river, upstream and downstream. Changes in the natural processes, such as a reduction in ...

Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the lack of methods for quantitatively characterizing the interactions that occur at specific promoters and enhancers in living cells. Here we show how such biophysical information can be revealed by a simple experiment in which a library of partially mutated regulatory sequences are partitioned according to their in vivo transcriptional activities and then sequenced en masse. Computational analysis of the sequence data produced by this experiment can provide precise quantitative information about how the regulatory proteins at a specific arrangement of binding sites work together to regulate transcription. This ability to reliably extract precise information about regulatory biophysics in the face of experimental noise is made possible by a recently identified relationship between likelihood and mutual information. Applying our experimental ...

The mechanisms by which influenza A virus (IAV) overcomes extracellular biological barriers in the respiratory tract, such as the mucus gel and periciliary laye...

Duties: To support, develop and execute research in sensory biophysics, as part of the research team. The research planned is aimed at elucidating the biophysical mechanisms of electroreception in honeybees and bumblebees. As research progresses, electroreception in other arthropod species will also be investigated. The successful candidate will have a track record in the field of sensory biophysics and/or insect electrophysiology. A key asset will be the capacity to identify and solve problems ... | Requirements: Experience in electrophysiology. Experience in sensory ecological research. Flexible, rigorous, innovative and conscientious approach to work, attention to details in data acquisition and analysis. PhD in Life Sciences. Record of oral and poster presentations at international conference. Publications in peer reviewed journals. Evidence of capability to work in multidisciplinary team...

Communications in Computational Physics (CiCP) publishes original research and survey papers of high scientific value in computational modeling of physical problems. Results in multi-physics and multi-scale innovative computational methods and modeling in all physical sciences will be featured. CiCP is a refereed, interdisciplinary journal edited by a group of world-wide leading scientists in diverse fields to guarantee its highest standard. The journal is published in a timely fashion in printed and electronic forms.

HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biol-ogy, medical, engineering, mathematics, and physical-science students or researchers can learn fun¬damental concepts and the application of new techniqu.... Full description. ...

HANDBOOK OF MODERN BIOPHYSICS Series Editor Thomas Jue, PhD Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-

Work involves the development of a biophysical model that can be used to adjust site index estimates for stands within the Mackenzie TSA. This project is proposed to run through two phases. Phase 1 will be completed in fiscal 2004 and involves the development of a biophysical model to predict site series based on environmental attributes of forest stands in the Mackenzie TSA and the construction of a sampling plan that will be used to calibrate initial site index estimates generated by the model. Phase 2, to be completed in fiscal 2005, involves the implementation of the sampling plan, calibration of the model, and final reporting. Refer to accompanying work plan for a detailed description of the project.

Correlations in sensory neural networks have both extrinsic and intrinsic origins. Extrinsic or stimulus correlations arise from shared inputs to the network and, thus, depend strongly on the stimulus ensemble. Intrinsic or noise correlations reflect biophysical mechanisms of interactions between neurons, which are expected to be robust to changes in the stimulus ensemble. Despite the importance of this distinction for understanding how sensory networks encode information collectively, no method exists to reliably separate intrinsic interactions from extrinsic correlations in neural activity data, limiting our ability to build predictive models of the network response. In this paper we introduce a general strategy to infer population models of interacting neurons that collectively encode stimulus information. The key to disentangling intrinsic from extrinsic correlations is to infer the couplings between neurons separately from the encoding model and to combine the two using corrections ...

My research focuses on the physical ecology of microorganisms and on microscale transport phenomena. With specific expertise in fluid mechanics, I use carefully controlled microfluidic experiments to understand how physical forces and chemical signals shape the behavior of microorganisms, particuarly in the ocean. My vision is that understanding microscale biophysical mechanisms is paramount to predicting ecosystem-level dynamics.. ...

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At the University of Notre Dame, molecular biophysics research focuses on molecular-level behavior and interactions of biological systems, with the aim of advancing progress in understanding, preventing, and curing diseases and understanding the sensitivities of organisms to various environmental stressors.

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Oncology and Biophysics: A Need for Integration The mainstream view of cancer as a mutated cell that has become dysfunctional and multiplies out of control (the somatic ..

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The Encyclopedia of Biophysics is envisioned both as an easily accessible source of information and as an introductory guide to the scientific literature. It includes entries describing both Technique

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Read about the specialisation in Biophysics at the Master of Science (MSc) Programme in Physics at Faculty of Science, University of Copenhagen.

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