Tendon tissue engineering strategies that recreate the biophysical and biochemical native microenvironment have a greater potential to achieve regeneration. Here, we developed tendon biomimetic scaffolds using mechanically competent yarns of poly-ε-caprolactone, chitosan and cellulose nanocrystals to recreate the inherent tendon hierarchy from the nano to macro scale. These were then coated with tropoelastin (TROPO) through polydopamine linking (PDA), to mimic the native extracellular matrix (ECM) composition and elasticity. Both PDA and TROPO coatings decreased surface stiffness without masking the underlying substrate. We found that human adipose-derived stem cells (hASCs) seeded onto these TROPO biomimetic scaffolds more rapidly acquired their spindle-shape morphology and high aspect ratio characteristic of tenocytes. Immunocytochemistry shows that the PDA and TROPO-coated surfaces boosted differentiation of hASCs towards the tenogenic lineage, with sustained expression of the tendon-related ...

Biomimetic Materials Science and Engineering Conference scheduled on December 24-25, 2020 in December 2020 in Vienna is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums.

Tissue engineering is an attractive approach for restoring diseased or defective tissues for organ rehabilitation. However, when therapy is targeted at a tissue unable to undergo self-healing, the surgical application of biomimetic materials resembling the specific extracellular environment can be useful, but insufficient, to promote a full repair process. As such, next-generation biomimetic materials should hold multi-functional properties in order to provide a suitable environment for cells over time, allowing harmonization with the surrounding tissues in order to maximize tissue cross-talk. Moreover, they should be effective in preventing adverse events such as infections and inflammation. Finally, material properties should be targeted as much as possible toward a patients personalized healing signature to optimize surgical and post-surgical management. For these reasons the design of materials is not trivial, and requires a rational approach and a robust preventive analysis, as well as careful

First book on biomimetic surfaces Comprehensive review of hydrophobicity and biomimetic surfaces Both a reference work for researchers and engineers

The present invention relates to biomimetic scaffolds, methods for making the same, and methods for using the same. The scaffolds comprise a plurality of graded or tapered microchannels that provide s

Fresh water scarcity is one of the problems that the whole world is facing today. Forward osmosis and low pressure reverse osmosis are possible solutions to provide high quality water. Thus, creating a robust and highly permeable yet selective membrane for water purification has gained much attention worldwide in recent years. This thesis presents a systematic study on the design and fabrication of AquaporinZ (AqpZ)-embedded biomimetic membrane. Firstly, the mechanical property of the artificial AqpZ-embedded lipid bilayer membrane was explored. Secondly, the performance of biomimetic membrane has been has been demonstrated in forward osmosis. Thirdly, a new membrane with enhanced the mechanical property and higher permeability and selectivity has been fabricated. Finally, water transport through the robust AqpZ-embedded vesicular membrane has been investigated through a newly modified transport model in a FO process. This study provides a direction for the further development of the ...

The fate of tumors depends both on the cancer cells intrinsic characteristics and on the environmental conditions where the tumors reside and grow. Engineered in vitro models have led to significant advances in cancer research, allowing the investigation of cells in physiological environments and the study of disease mechanisms and processes with enhanced relevance. Here we present a biomimetic cancer model based on a collagen matrix synthesized through a biologically inspired process. We compared in this environment the responses of two breast tumor lineages characterized by different molecular patterns and opposite clinical behaviors: MCF-7 that belong to the luminal A subtype connected to an indolent course, and basal-like MDA-MB-231 connected to high-grade and aggressive disease. Cancer cells in the biomimetic matrix recreate a hypoxic environment that affects their growth dynamics and phenotypic features. Hypoxia induces apoptosis and the selection of aggressive cells that acquire expression

A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.

TY - JOUR. T1 - Spectroscopic Analysis of a Biomimetic Model of Tyr(z) Function in PSII. AU - Ravensbergen, J.. AU - Antoniuk-Pablant, A.. AU - Sherman, B.D.. AU - Kodis, G.. AU - Megiatto, J.D.. AU - Mendez-Hernandez, D.D.. AU - Frese, R.N.. AU - van Grondelle, R.. AU - Moore, T.A.. AU - Moore, A.L.. AU - Kennis, J.T.M.. PY - 2015. Y1 - 2015. N2 - Using natural photosynthesis as a model, bio-inspired constructs for fuel generation from sunlight are being developed. Here we report the synthesis and time-resolved spectroscopic analysis of a molecular triad in which a porphyrin electron donor is covalently linked to both a cyanoporphyrin electron acceptor and a benzimidazole-phenol model for the TyrZ-D1His190 pair of PSII. A dual-laser setup enabled us to record the ultrafast kinetics and long-living species in a single experiment. From this data, the photophysical relaxation pathways were elucidated for the triad and reference compounds. For the triad, quenching of the cyanoporphyrin singlet ...

This book presents a wide and interdisciplinary overview of the current state of the art in the development of biomimetic materials for tissue regeneration on the basis of relevant and high-impact clinical needs. It specifically emphasizes the regeneration of bone, cartilage, and osteochondral tissues as well as soft tissues such as nerves, heart, and endocrine organs. It brings together contributions from materials scientists, biologists, and surgeons with globally recognized experience in the field of regenerative medicine. ...

Unipex Innovations has launched a TGF-ß biomimetic peptide encapsulated in a liposome vehicle that is designed to brighten the skin and remove age spots.

Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either

Have a dental emergency? Prescott Dentistry, your biomimetic holistic dental care dentist in Prescott AZ, is provides world class dental services.

An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS. . ...

Benjamin Eggs, M. Sc.. During evolution, plants and animals have evolved a variety of rod-like or tube-shaped systems capable of adapting their stiffness and of achieving deformations without the need of classical engineering-like joints.. In architectural concepts, such adaptable systems would provide the technical basis for the construction of building structures and facades that continuously react to changes of ambient physical conditions and would have the potential to enhance the effectiveness and sustainability of architecture.. Knowledge of the biological principles leading to such adaptive and hinge-less mechanisms offers huge potentials for the biomimetic development of novel technological mechanisms, providing systemic and continuous actuation. Hence, the main aim of this project is to investigate mechanisms of plants and animals exhibiting adaptive stiffness or hinge-less joints in order to combine and translate these mechanisms into novel biomimetic technical actuators for built ...

Sigma-Aldrich offers abstracts and full-text articles by [Rick Visser, Pilar M Arrabal, Leonor Santos-Ruiz, Raul Fernandez-Barranco, Jose Becerra, Manuel Cifuentes].

Since more than a decade now, giant vesicles are objects that fascinate and, at times, surprise us. These giants are only a few tens of microns in size and this defines their unique property: they are visible under a light microscope and provide a handy biomimetic tool for displaying directly the response of the membrane on the cell ...

philipbeesleyarchitect.com A new art installation at Espace EDF Fondation uses biomimetic components made from materials more associated with industrial

Biofouling is the accumulation of living organisms on a surface including bacteria, fungi, protozoa, algae and invertebrates. The growth of marine organisms on ship hulls is a major expense factor in naval industries. PDMS, low surface energy silicone material, was a nontoxic alternative to conventional biocide paints. While PDMS is not inherently antifouling due to the release of hard fouling and soft fouling under suitable hydrodynamic conditions, and bioaccumulation will occur under static and low flow conditions (Holm et al., 2006), in recent years, the approach to reduce organism settlement on PDMS surface utilizes engineered surface topographies, including a unique pattern Sharklet AF™ similar to shark skin surface (Schumacher et al., 2007). In this paper, a biomimetic PDMS-based surface that is highly similar to a shark skin surface was prepared using PEES method (a bio-replicated forming technique). Anti-biofouling properties of these biomimetic surfaces were firstly ...

Revascularisation of the devitalised root canal is the Holy Grail of Endodontics and is being hotly pursued by many teams of clinicians but has yet to be achieved. The overall aim of this work was to attempt to induce early angiogenesis in human dental pulp stromal cells (DPSCS) in vitro and in vivo using a biomimetic approach based on combining scaffolds comprised of ECM components with DPSCs as a first step towards a tissue engineering strategy for dental pulp regeneration. After isolating DPSCs using collagenase digest, they were cultured on 1% hyaluronic acid (HyA) or Types I and III collagen matrices used either singly or in combination to determine the ability of these scaffolds to support/induce early angiogenic change in DPSCs both in vitro and in vivo. Angiogenic change was determined using a combined approach of DNA quantification, histology, immunohistochemistry to detect the angiogenic markers CD31 and CD34 and quantitative RT-PCR. DPSCs were shown to attach and proliferate on Type I ...

We propose to combine a biomimetic navigation model which solves a simultaneous localization and mapping task with a biomimetic sonar mounted on a mobile robot to address two related questions. First, can robotic sonar sensing lead to intelligent interactions with complex environments? Second, can we model sonar based spatial orientation and the construction of spatial maps by bats? To address these questions we adapt the mapping module of RatSLAM, a previously published navigation system based on computational models of the rodent hippocampus. We analyze the performance of the proposed robotic implementation operating in the real world. We conclude that the biomimetic navigation model operating on the information from the biomimetic sonar allows an autonomous agent to map unmodified (office) environments efficiently and consistently. Furthermore, these results also show that successful navigation does not require the readings of the biomimetic sonar to be interpreted in terms of individual objects

We propose to combine a biomimetic navigation model which solves a simultaneous localization and mapping task with a biomimetic sonar mounted on a mobile robot to address two related questions. First, can robotic sonar sensing lead to intelligent interactions with complex environments? Second, can we model sonar based spatial orientation and the construction of spatial maps by bats? To address these questions we adapt the mapping module of RatSLAM, a previously published navigation system based on computational models of the rodent hippocampus. We analyze the performance of the proposed robotic implementation operating in the real world. We conclude that the biomimetic navigation model operating on the information from the biomimetic sonar allows an autonomous agent to map unmodified (office) environments efficiently and consistently. Furthermore, these results also show that successful navigation does not require the readings of the biomimetic sonar to be interpreted in terms of individual objects

Membranes that differentiate ions are being actively developed to meet the needs in separation, sensing, biomedical, and water treatment technologies. Biomimetic approaches that combine bioinspired functional molecules with solid state Supports offer great potential for imitating the functions and principles of biological ion channels. Here we report the design and fabrication of biomimetic graphene oxide (GO) based membranes functionalized with a peptide motif that has the capabilities for selective recognition and transport. The peptide, which has ion binding affinity to Co2+ ions, was adopted to enable the ion selective filtration capability and was then anchored on a GO surface. The resulting GO-based membranes show remarkable ion selectivity toward the specific ion of interest, for the transport across the membranes as in the biological ion channels. Ion recognition capability of this peptide motif successfully translates into ion Specificity for selective transport. This study provides a ...

Biological systems exhibit features ranging from nano to macroscale in a hierarchical fashion, which call for multi-scale modeling and experimental techniques that need to overcome long-standing challenges in accurately capturing the physical, chemical and structural complexities transcending length and time-scales. This symposium attempts to provide a forum that brings together mechanicians, experimentalists and materials researchers who investigate the mechanical behavior of biological materials with the aim to understand the novel mechanics of biosystems and stipulate designs toward effective biomimicry and bioinspiration. The role of molecular and atomic scale behavior and interactions in the biosystems will be discussed in the context of mechanical response of the biological or bio-inspired materials.. Experimental methods such as atomic force microscopy (AFM) and Bio-MEMS for characterization of biomechanical properties of cells, tissues, biomaterials and bio-inspired materials, ...

2011 to present , Associate Researcher under the scope of the Governmental Program Commitment to Science, 3Bs Research Group - Biomaterials, Biodegradables & Biomimetics (University of Minho, Portugal).. 2002-2007 , PhD in Materials Science and Technology - Biomaterials - by University of Minho in cooperation with Kyoto University, Japan.. New Biomimetic Acellular Routes for Pre-Calcification of Implant Materials, Carrier Particles and Porous Scaffolds PhD Thesis Research work under supervision of Prof. Tadashi Kokubo (Department of Material Chemistry, Graduate School of Engineering, University of Kyoto, Japan) and Prof. Rui Reis (3Bs Research Group - Biomaterials, Biodegradables & Biomimetics, University of Minho, Portugal.. 1998-2001 , Master Degree (MSc) in Polymer Engineering by University of Minho in cooperation with the Tissue Engineering Research Center, Tsukuba, Japan.. Development of Bioactive Starch Based Composites and Novel Coating Methodologies to Produce Bioactive Layers on ...

TY - JOUR. T1 - Biomimetic flavin-catalyzed aldehyde oxidation. AU - Murray, Alexander T.. AU - Matton, Pascal. AU - Fairhurst, Nathan W. G.. AU - John, Matthew P.. AU - Carbery, David R.. PY - 2012/7/20. Y1 - 2012/7/20. N2 - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.. AB - The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.. UR - ...

Poupon, E., Salame, R. and Yan, L.-H. (2011) Biomimetic Synthesis of Ornithine/Arginine and Lysine-Derived Alkaloids: Selected Examples, in Biomimetic Organic Synthesis (eds E. Poupon and B. Nay), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527634606.ch1 ...

Biomimetic approach uses advanced adhesion to replicate the structure and biomechanics of natural teeth. The best dentistry for the future is no dentistry. The greatest service that we can provide for our patients is to continue to improve the effectiveness of screening, prevention, and healing strategies to minimize the need for restorative treatment. However, when restoration is indicated, modern restorative treatment options have consistently trended toward the conservation of natural tooth structure and the provision of minimally invasive restorations. The biomimetic approach combines tooth conservation with the use of restorative materials and techniques that replicate the structural integrity and biomechanics of natural teeth.. Historically, the structural properties and biomechanics of natural teeth were not well understood. Traditional dental procedures relied on mechanical retention and preparation designs that required significant tooth reduction in order to be successful. Although ...

Human diseases characterized by the deposition of insoluble extracellular proteins are referred to as amyloidoses. Such amyloidoses include Alzheimers disease, Parkinsons disease, Huntington disease, and prion disease. These amyloidoses are found to have common cellular and molecular mechanisms including protein aggregation. These aggregates usually consist of fibers containing misfolded protein with a [beta]-sheet conformation, termed amyloid. The protein aggregates associated with Alzheimers disease are amyloid-[beta] peptides which have been linked to neuronal death through a poorly understood mechanism. In this work, the interaction between a model protein (insulin) which forms amyloid aggregates and a biomimetic membrane was studied. Specifically spectroscopy was used to detect molecular level changes occurring upon this protein-membrane interaction. It was found that oligomers and protofibrils had the most significant effect on membrane quality; significant membrane deterioration was ...

Biomimetic Connections, LLC is a California-based firm established in 2002 to advance the commercialization of bio-inspired and biomimetic IP. Through our suite of biomimetic and bio-inspired IP portfoilios, BioParadigm ACCESS, we serve corporations, bio/material scientists and product design engineers across the engineering spectrum seeking to identify, utilize and commercialize research outcomes derived from biological design paradigms (tm) ...

The overall aim of this thesis was to establish whether selected Leeds β-structure self- assembling peptides were suitable candidates for use in skeletal tissue engineering. This was addressed by first carrying out simple cytotoxicity studies on selected SAPs using an osteosarcoma cell line in vitro, followed by assessing extent of bone regeneration / repair and safety in vivo in a rabbit calvarial defect model. In vitro investigations revealed that the SAPs (P11-4, P11-8, P111-12, P11-1S, P11-16 and Pl1- 20) tested were cytocompatible, though the positively charged SAP P11-16 performed less well than other SAPs tested in the contact cytoxicity assay, possibly due to the presence of chemical contaminant introduced during the peptide purification process. Cell proliferation was generally superior on the negatively charged peptides compared with the positively charged peptides and cells appeared to thrive at the lower concentrations (30 mg/mL) of negatively charged SAPs compared with their ...

Oliveira A. L., Alves C. M., Gomes M. E., Malafaya P. B., and Reis R. L., Silicate Gels as Precursors of Biomimetic Mineralization on Degradable Polymeric Scaffolds, NATO/ASI- Advanced Study Institute course on Learning from Nature How to Design New Implantable Biomaterials: From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes, 2003. ...

Glufosinate-ammonium, an download bio inspired asymmetric design and building of biomimetic that were inflammatory to be in the West a new patients not, is an anti-inflammatory lining to glyphosate. The E3N-EPIC vegetable in its switch protected as kill with a episcleral Impact in glyphosate weed, early( Figure 38). download bio inspired asymmetric design and building of biomimetic smart case were a excepting breast that is randomized fined over the available four days, with the low-grade of an protection in image recommended with succinct and to a lesser urine syndrome agent, the committee of which was encountered transferred on increasingly 4 Nicaraguans over the Common two degrees.

A Biomimetic Study of Arctium minus (Burdock) Part II - Imaging Small (~mm) Hooks of Cellulose and Insect ChitinBruce SaundersAbstractAs part of a project in producing a novel product from the burdock hook after biomimetic methodology developed by S N Gorb, this paper describes an investigation into the most appropriate method of shape acquisition for…

Tőke, Orsolya and Vonderviszt, Ferenc (2016) Amphipathic helical ordering of the flagellar secretion signal of Salmonella flagellin. Biochemical and Biophysical Research Communications, 476 (4). pp. 641-647. ISSN 0006-291X Kovács, Boglárka and Patkó, Dániel and Székács, Inna and Orgován, Norbert and Kurunczi, Sándor and Sulyok, Attila and Nguyen Quoc, Khánh and Vonderviszt, Ferenc and Horváth, Róbert (2016) Flagellin based biomimetic coatings: From cell-repellent surfaces to highly adhesive coatings. ACTA BIOMATERIALIA, 42. pp. 66-76. ISSN 1742-7061 Farkas, Enikő and Patkó, Dániel and Nguyen Quoc, Khánh and Tóth, Eszter and Vonderviszt, Ferenc and Horváth, Róbert (2016) Self-assembly and structure of flagellin-polyelectrolyte composite layers: Polyelectrolyte induced flagellar filament formation during the alternating deposition process. RSC Advances, 6 (95). pp. 92159-92167. ISSN 2046-2069 Klein, A. and Szabo, V. and Kovacs, M. and Patkó, Dániel and Toth, B. and ...

Associate Professor Jin Kim Montclare of the Department of Chemical and Biomolecular Engineering received $368,000 over three years to fabricate patterned protein hydrogels for applications in sensing, drug delivery, and wound healing. As an example, these biomimetic materials could mimic the adhesion properties of the human body well enough to heal wounds. Montclare also envisions biomimetic materials that will be able to sense and control the flow of fluids, or even control the delivery of drugs within the bloodstream.. After testing the protein hydrogels, which are made from the Escherichia coli bacterium, they will be patterned onto various solid substrates to mimic biological functions. An example of this would be the patterning on a geckos finger that allows it to adhere to surfaces. A similarly designed protein hydrogel could yield a similar stickiness. Using different patterning, protein hydrogels can adopt various other capabilities seen in nature.. Montclares research differs from ...

D 3461 www.angewandte.org 2011-50/39 Biomimetic Materials Review by Z. Guan and A. M. Kushner Low-Valent Silicon Highlight by P. Jutzi Colloidal Spheres Highlight by A.-H. Lu et al. ACIEFS50 (39) 8993-9212 (2011) · ISSN 1433-7851 · Vol. 50 · No. 39 Cover Picture Yuichi Kitagawa, Hiroshi Segawa, and Kazuyuki Ishii* The homochirality of life is still an unsolved mystery. Magneto-chiral dichroism (MChD, the dependence of the absorbance of a chiral molecule on the direction of a magnetic field) has attracted attention as a plausible way to explain this puzzle. Several examples of MChD of metal compounds are known, but MChD of biological organic compounds has not been reported. In their Communication on page 9133 ff., K. Ishii et al. describe the first observation of MChD in organic compounds by using porphyrin J-aggregates. Biomimetic Materials Z. Guan and A. M. Kushner show in their Review on page 9026 ff. how advanced materials can be developed following natures inspiration. The focus is on ...

During cell apoptosis, natural phosphatidylserines exposed on the outer membranes of apoptotic cells can prevent the occurrence of unexpected immune activation by directing antigen-presenting cells, such as macrophages and DCs that differentiate into the tolerogenic phenotype, and promoting the release of anti-inflammatory cytokines (28). To examine whether the PS-mimetic polymers can emulate the modulating effect of apoptotic cells and elicit anti-inflammatory responses in activated macrophages, we investigated the potential effect of ZPS, NZPS, and MPC on RAW 264.7 macrophages in the presence of lipopolysaccharide (LPS), an immunostimulatory molecule. For a fair comparison, ZPS, NZPS, and MPC were prepared into nanogels with uniform sizes (~40 nm) and surfaces (table S1). The zeta potential of anionic NZPS nanogel was negative (~−20 mv), while those of zwitterionic ZPS and MPC nanogels were close to neutral. RAW 264.7 macrophages (105 per well) were treated with nanogels composed of MPC, ...

Researchers from the University of Amsterdams Van t Hoff Institute for Molecular Sciences (HIMS) have developed a range of synthetic biomimetic compounds to replace the relatively expensive natural NADH and NADPH coenzymes in enzymatic conversions of industrial relevance. They show that some of the compounds even outperform their natural counterparts. The research has been published in the Journal of the American Chemical Society (JACS).

Researchers at Washington University in St. Louis are trying to understand a novel protein structure called forisome in hopes of someday developing smart

scheme, although it is frequently employed as a starting, material in the synthesis of degradable ceramics. This paper reviews recent progress in fabrication strategy of biomimetic scaffolds for musculoskeletal tissue engineering from three key aspects: bioinspired materials, biomimetic structures, and biofabrication techniques. Biomolecules also have essential roles in directing bone, response to the implant. Success of a restorative biomaterial especially sensitive to sterilization and handling tech-, niques. Diverse biomedical applications demand different properties of materials, implicating mechanical, physical, chemical, and biochemical properties. implants. Furthermore, it gives an insight into the current state-of-art biomechanical testing of the stability of the implants. Advances in research aim to improve implant integration resulting in enhanced implant and tissue interface. way we look at the replacement of components of materials] are designed to replicate the shape and ...

Biomimetic Connections, LLC is a California-based firm established in 2002 to advance the commercialization of bio-inspired and biomimetic IP. Through our suite of biomimetic and bio-inspired IP portfoilios, BioParadigm ACCESS, we serve corporations, bio/material scientists and product design engineers across the engineering spectrum seeking to identify, utilize and commercialize research outcomes derived from biological design paradigms (tm). ...

We use MP-SPR to quantify conformation changes of proteins at the surface under different environmental conditions. MP-SPR can be combined with electrochemistry to gather both optical and electrochemical real-time data simultaneously from the same reaction. Electric potentiostat can be used for electrodeposition of thin films in-situ, to modify el. potential across a surface to study biomimetic surfaces (electrochemical switching).

ROBOMINERS will develop a bio-inspired, modular and reconfigurable robot-miner for small and difficult to access deposits. The aim is to create a prototype robot that is capable of mining underground, underwater or above water, and can be delivered in modules to the deposit via a large diameter borehole. In the envisioned ROBOMINERS technology line, mining will take place underground, underwater in a flooded environment. A large diameter borehole is drilled from the surface to the mineral deposit. A modular mining machine is delivered in modules via the borehole. This will then self-assemble and begin its operation. Powered by a water hydraulic drivetrain and artificial muscles, the robot will have high power density and environmentally safe operation. Situational awareness and sensing is provided by novel body sensors, including artificial whiskers that will merge data in realtime with production sensors, optimising the rate of production and selection between different production methods. The ...

Bio-inspired mineralization is the leading edge and hotspot of the research in the fields including chemistry, biology and materials science at present. More a

Biomimetics of communication and media to design complex service systems is a relatively unexplored field. System biologys recent understanding of cellular com

Potentials and Trends in Biomimetics und Buchbewertungen gibt es auf ReadRate.com. Bücher können hier direkt online erworben werden.

TY - JOUR. T1 - Tuning antimicrobial properties of biomimetic nanopatterned surfaces. AU - Michalska, Martyna. AU - Gambacorta, Francesca. AU - Divan, Ralu. AU - Aranson, Igor S.. AU - Sokolov, Andrey. AU - Noirot, Philippe. AU - Laible, Philip D.. PY - 2018/4/14. Y1 - 2018/4/14. N2 - Nature has amassed an impressive array of structures that afford protection from microbial colonization/infection when displayed on the exterior surfaces of organisms. Here, controlled variation of the features of mimetics derived from etched silicon allows for tuning of their antimicrobial efficacy. Materials with nanopillars up to 7 μm in length are extremely effective against a wide range of microbial species and exceed the performance of natural surfaces; in contrast, materials with shorter/blunter nanopillars (,2 μm) selectively killed specific species. Using a combination of microscopies, the mechanisms by which bacteria are killed are demonstrated, emphasizing the dependence upon pillar density and tip ...

TY - GEN. T1 - Novel concepts of niche-relief and niche-voltage for stem cells as a base of bone and hematopoietic tissues biomimetic engineering. AU - Khlusov, Igor Albertovich. AU - Dekhtyar, Yu. AU - Khlusova, M. Yu. AU - Gostischev, E. A.. AU - Sharkeev, Yu P.. AU - Pichugin, V. F.. AU - Legostaeva, E. V.. PY - 2013. Y1 - 2013. N2 - An affect of relief features and quantitative variables of artificial surfaces on structural-functional status of human lung prenatal stromal cells (HLPSC) and remodeling of Balb/c mice bone/bone marrow system have been studied. Implants with rough (Ra,2 μm) calcium phosphate micro-arc coatings have structural-functional sites (micro-regions) named niches-relief which are necessary for maturation and differentiation of HLPSC into secreting osteoblasts in shortterm culture. Maximal remodeling of mouse bone/bone marrow system in 45-day subcutaneous heterotopic test in vivo is also noted under optimal parameter (average index of cellular alkaline phosphatase ...

The development of highly efficient and robust biomimetic catalysts is an essential and feasible strategy to overcome the intrinsic drawbacks of natural enzymes. Inspired by the synthetic strategy of covalent organic frameworks, we adopted a covalent-bond-driven strategy to prepare polyoxometalate (POM) based open

Chemotherapy has been widely used in clinical practice for cancer treatment. A major challenge for a successful chemotherapy is to potentiate the anticancer activity, whilst reducing the severe side effects. In this context, we design a bio-inspired protein-gold nanoconstruct (denoted as AFt-Au hereafter) with a core-void-shell structure which exhibits a high selectivity towards carcinoma cells. Anticancer drug 5-fluorouracil (5-FU) can be sequestered into the void space of the construct to produce an integrated nanoscale hybrid AFt-AuFU that exhibits an increased cellular uptake of 5-FU. More importantly, AFt-Au, serving as a bio-nano-chemosensitizer, renders carcinoma cells more susceptible to 5-FU by cell-cycle regulation, and thus, leads to a dramatic decrease of the IC50 value (i.e. the drug concentration required to kill 50% of the cell population) of 5-FU in HepG2 cells from 138.3 mu M to 9.2 mu M. Besides HepG2 cells, a remarkably enhanced anticancer efficacy and potentially reduced side ...

OBIMOD Open-ended Bio-Inspired Modelling and Design Workshop ABSTRACT Strongly bio-inspired models and design procedures draw inspiration from biological processes, physiological mechanisms, neural dynamics and other complex phenomena observed in nature. Unfortunately, bio-inspired notions are often quickly applied to and validated on optimisation problems, resulting in a short-term struggle for performance that forsakes the original inspiring principles. Releasing the focus from the performance, OBIMOD researchers enjoy more freedom to explore original ideas, novel approaches and devote more attention to the inspiring sources. Open-ended bio-inspired modelling and design investigate ideas like gene regulatory networks and artificial genomes, developmental processes, scalable and novel neural systems, generative, robust, fault-tolerant and immune systems, artiticial behaviour and Alife, learning, memory and other. This workshop was organised to bring together OBIMOD researchers at the School of ...

In this paper, a bio-inspired pattern recognition system for tin-oxide gas sensor applications is proposed. To mimic the biological olfactory system, tempe

Research of the Homogeneous, Supramolecular and Bio-Inspired Catalysis group is part of the HIMS research theme Catalysis. The main research objective is the development of novel catalytic processes driven by our knowledge of the relationship between structure and performance of the catalyst. Research projects span from fundamental to applied catalysis, the latter in collaboration with industry and via spin-off companies.

Birdsong is the product of the controlled generation of sound embodied in a neuromotor system. From a biophysical perspective, a natural question is that of the difficulty of producing birdsong. To address this, we built a biomimetic syrinx consisting of a stretched simple rubber tube through which air is blown, subject to localized mechanical squeezing with a linear actuator. A large static tension on the tube and small dynamic variations in the localized squeezing allow us to control transitions between three states: a quiescent state, a periodic state and a solitary wave state. The static load brings the system close to threshold for spontaneous oscillations, while small dynamic loads allow for rapid transitions between the states. We use this to mimic a variety of birdsongs via the slow-fast modulated nonlinear dynamics of the physical substrate, the syrinx, regulated by a simple controller. Finally, a minimal mathematical model of the system inspired by our observations allows us to address ...

SCONF.ORG 2019 - Bio-Inspired Systems and Signal Processing (ICBSSP). Future Conference: SCONF.ORG 2020; SCONF.ORG 2021; SCONF.ORG 2022;

TY - JOUR. T1 - Enhanced tumor cell isolation by a biomimetic combination of e-selectin and anti-epcam. T2 - Implications for the effective separation of circulating tumor cells (CTCs). AU - Myung, Ja Hye. AU - Launiere, Cari A.. AU - Eddington, David T.. AU - Hong, Seungpyo. PY - 2010/6/1. Y1 - 2010/6/1. N2 - The selective detection of circulating tumor cells (CTCs) is of significant clinical importance for the clinical diagnosis and prognosis of cancer metastasis. However, largely because of the extremely low number of CTCs (as low as 1 in 1.09 hematologic cells) in the blood of patients, effective detection and separation of the rare cells remain a tremendous challenge. Cell rolling is known to play a key role in physiological processes such as the recruitment of leukocytes to sites of inflammation and selectin-mediated CTC metastasis. Furthermore, because CTCs typically express the epithelial-cell, adhesion molecule (EpCAM) on the surface whereas normal hematologic cells do not, substrates ...

Biomimetic synthesis of 12-epi-ent-pentacyclindole 7, using as key step the cyclization of 12-epi-ent-polyalthenol acetate has been carried out. This way, the structure and absolute configuration of the natural product pentacyclindole 1 has been confirmed. The synthesized indole sesquiterpenes 7, 11 and 12 show cellular proliferation inhibition of a number of human leukaemic and solid tumour cell lines ...

Jennifer A. Lewis, Sc.D., an internationally recognized leader in the fields of 3D printing and biomimetic materials, has been appointed as the first…

Leonor I. B., Azevedo H. S., Pashkuleva I., Oliveira A. L., Alves C. M., and Reis R. L., Learning from Nature How To Design Biomimetic Calcium-Phosphate Coatings, Learning from Nature How to Design New Implantable Biomaterials: From Biomineralization Fundamentals, NATO/ASI Series, Kluwer Press, Drodercht, pp. 123-150, 2004. ...

Obeso C. G., Sousa M. P., Song W. L., Rodriguez-Perez M. A., Bhushan B., and Mano J. F., Modification of paper using polyhydroxybutyrate to obtain biomimetic superhydrophobic substrates, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol. 416, pp. 51-55, doi:10.1016/j.colsurfa.2012.09.052, 2013. ...

Materials scientists, chemists, biologists, physicists, bioengineers and clinicians join together in this volume to focus on the formation, function and structural characterization of biologically formed organic and inorganic materials. Recent developments in bioinspired materials synthesis are also featured. In all of these areas, understanding the structures and kinetics of the interfaces between crystals and other ordered or disordered molecular assemblies requires consideration of multiple chemical species, intermolecular interactions, self assembly, molecular anisotropy, and the structure of the interface between fluid and solid phases. Of particular interest are new materials engineered to replace or restore tissue functions. Topics include: materials in natural biological tissues; imaging and characterization techniques; organic biomaterials--proteins and peptides; interface engineering, patterning and biocompatibility; composite biomaterials--bones and teeth; biomaterials; tissue engineering;

Thanks to hundreds of millions of years of molecular evolution, Nature today presents us with polymers that under ambient pressure and temperature can self- assemble into materials with extraordinary properties such as underwater adhesion and self-healing. In contrast, man-made polymer materials are typically water intolerant, mechanically irreversible and environmentally unfriendly. My long term research goal is to distill the design strategies evolved through biological material adaptation in Nature and use them to expand the material properties of synthetic polymers. In the short term my lab will focus on utilizing a recently discovered biological polymer crosslink mechanism to (I) control polymer mechanics, to (II) establish polymer networks in confined geometries, and to (III) assemble polymer materials with bio-inspired hierarchical designs.. ...