Mark Davis, ND. Fecal microbiota transplantation (FMT) is also known as human probiotic infusion, fecal transplant, fecal bacteriotherapy, fecal slurry, and gut flora rehabilitation and has been humorously referred to as "transpoosion." The procedure consists of collecting stool from a healthy donor; suspending it in water, normal saline, or 4% milk; and administering it to the patient (most frequently via enema but also via colonoscope, nasogastric or nasoduodenal tube, rectal tube, or even [anecdotally] orally as a milkshake1). This massive infusion of healthy colonic bacteria has been used as far back as the 17th century in veterinary medicine to treat digestive disturbances2 and as early as 1958 in humans to treat pseudomembranous colitis.3. Fecal microbiota transplantation has a 90% success rate in curing Clostridium difficile-associated chronic diarrhea, colitis, and pseudomembranous colitis,4 which affect half a million and kill 15 000 to 20 000 Americans per year.5 Fecal microbiota ...
The investigators propose to use autologous fecal microbiota transplantation (AFMT) to acute myeloid leukemia (AML) patients treated with intensive chemotherapy and antibiotics in order to restore the balance of their intestinal microbiome and thereby eradicate treatment-induced multidrug resistant bacteria (MDRB), infection-related complications, as well as sequelae to the gastrointestinal tract. Therefore, the investigators propose to perform a single-arm multicentre prospective fecal microbiota transplantation (FMT) trial in AML patients receiving intensive chemotherapy, and who are usually heavily treated with broad-spectrum antibiotics during aplasia that generate a profound status of dysbiosis. For this purpose, at the time of admission and AML diagnosis, patients will be requested to donate stools that will be comprehensively screened, and if deemed appropriate according to protocol criteria, conditioned and stored frozen until future processing and transplantation after aplasia completion ...
Dysbiosis plays a major role in the etiology of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) is a new promising option for IBD treatment. We aimed to assess the effectivene
Phys.org Science News Wire : Largest Planned Fecal Microbiota Transplantation (FMT) study enrolls first patient -- a press release is provided to you ìas isî with little or no review from Phys.org staff.
We established a standard bacteria isolation from donated fresh stool in lab.Then the bacteria is transplanted to mid-gut (at least below the second part of duodenum ) through regular gastroscope. Participants in this study will be randomly assigned to receive fecal microbiota transplantation only once or traditional therapy, and accept follow-up for at least one year. Blood tests,OGTT and magnetic resonance spectroscopy will be used to assess participants at study start and at study completion ...
Biological therapies in the systemic management of psoriasis; International Consensus Conference. Br J Dermatol, 151 (2004), pp. 3-17. Medline. 4. D. Thaci. Cosentyx is the only biologic that can be used as first-line systemic therapy in the treatment of psoriasis and as an alternative to treatments that have significant side effects 1; all other biologics are recommended for second-line therapy 2-4. Currently, all biologic treatments for psoriasis, including anti-tumor necrosis factor therapies (anti-TNFs) and Stelara (ustekinumab) are recommended for second-line systemic therapy in Europe 2-4. Biological therapies in the systemic management of psoriasis: International Consensus Conference. Biological therapies in the systemic management of psoriasis: International Consensus Conference. Article September 2004 British Journal of Dermatology. Biological therapies in the systemic management of psoriasis: International Consensus Conference. Br J Dermatol. 2004;151 Suppl 69:3-17. Biologic agents ...
Biological therapy is a treatment that uses your bodys immune system to fight cancer cells rather than attacking those cells directly. For carefully selected people, biological therapy may target cancer cells to avoid damage to normal cells, prevent or slow tumor growth, and prevent the spread of cancer cells. Although it can have side effects, typically this type of therapy is less invasive and less toxic than conventional cancer treatments are. Biological therapy for cancer includes immunotherapy, targeted therapy and therapy that inhibits the growth of blood vessels (anti-angiogenesis).
Biological therapy is used treat certain types of non-Hodgkin lymphoma. Learn how and when biological therapy is used and side effects of biological therapy.
FMT as a treatment modality has also been tested in a range of other diseases, such as inflammatory bowel disease (IBD), irritable bowel syndrome, obesity and metabolic syndrome, as well as neurological and psychological disorders, although most reports of the latter category are merely anecdotal. Yet, the results so far are not convincing. Reports about using FMT to treat IBD patients show considerable heterogeneity in terms of clinical effect (Moayyedi et al, 2015), whereas efficacy in patients with metabolic syndrome was transient. Insulin resistance improved 6 weeks after the FMT, but at 12 weeks, no significant effect was observed anymore on metabolic parameters and fecal microbiota composition (Vrieze et al, 2012).. The reason why FMT has such variable efficacy is probably due to the stability and resilience of the gut microbiota. CDI patients who have been treated multiple times with antibiotics have most of their bacterial diversity wiped out; FMT effectively repopulates this vacated ...
Clin Gastroenterol Hepatol. 2011 Dec;9(12):1044-9. doi: 10.1016/j.cgh.2011.08.014. Epub 2011 Aug 24. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Review
Key takeaways from Randi Lundbergs review of the pros and cons of using antibiotic-treated or germ-free mice in fecal microbiota transplant studies.
Introduction. There is a growing body of evidence highlighting the possible interactions between the microbiota and cancer. However, little is known about the consequence on the microbiota of the intensive chemotherapy in patients with AML. Indeed, intensive treatments of AML are known to negatively impact gut microbiota composition; it is measured by a deep shutdown of diversity indices (eg. Simpson), also called dysbiosis. Decrease in microbiota diversity may impact the immune system and may have consequences on the outcome of AML patients. Therefore, development of strategies to manipulate the gut microbiota may minimize treatment-related complications and potentially improve outcomes. With this background, we developed a single arm prospective phase I/II multicenter trial (ClinicalTrials.gov Identifier: NCT02928523) aiming to evaluate use of auto-FMT in AML patients treated with intensive chemotherapy and antibiotics. Patients and methods. For this purpose, at the time of admission and AML ...
Key Points. Bacterial diversity was restored after FMT with oral frozen capsules, with improvement of diarrhea.Oral FMT for steroid-refractory acute gGVHD is f
Professor Borody is most famous for his ground-breaking work developing the triple therapy cure for peptic ulcers in 1987, which has saved hundreds of thousands…
Gastroenterology & Hepatology. January 2015, Volume 11, Issue 1. Woo Jung Lee, MD, Lakshmi D. N. Lattimer, MD, Sindu Stephen, MD, Marie L. Borum, MD, and David B. Doman, MD. Dr Lee and Dr Lattimer are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Stephen is a gastroenterologist in Silver Spring, Maryland. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC and the director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; she is also affiliated with Medical Faculty Associates. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine.. Address correspondence to: Dr David B. Doman, 12012 Veirs Mill Road, Silver Spring, MD 20906, Tel: 301-942-3550, E-mail: [email protected] Abstract: The symbiotic ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Excision BioTherapeutics, a life science company focused on the development and commercialization of advanced gene editing therapeutics for the treatment of life-threatening disease caused by neurotropic viruses, recently announced it has completed a $10 million seed round of financing, led by ARTIS Ventures. The investment will enable the company to enter into human clinical trials with its HIV-1 targeted CRISPR platform, giving Excision BioTherapeutics the first effort to fully remove/excise the HIV-1 genome from all human cells and tissues. In addition, Excision BioTherapeutics is extending this approach to other viruses by targeting their genetic elements, and eliminating them permanently from the patient. Regarding this development, Thomas Malcolm, Ph.D, Excision BioTherapeutics founder, president and CEO, stated "Excisions mission has always been to advance gene editing therapeutics into safe and efficacious medicines that will eradicate or disrupt viral genes in human patients. The ...
Biological therapy (also called immunotherapy, biological response modifier therapy, or biotherapy) uses the bodys immune system to fight cancer. The cells, antibodies, and organs of the immune system work to protect and defend the body against foreign invaders, such as bacteria or viruses. Doctors and researchers have found that the immune system might also be able to both determine the difference between healthy cells and cancer cells in the body, and to eliminate the cancer cells. (By itself, the immune system is not always good at destroying cancer cells; if it were, people would not get cancer.). Biological therapies are designed to boost the immune system, either directly or indirectly, by assisting in the following:. ...
Kaltsonoudis et al.9 conducted a prospective study in 77 patients with inflammatory rheumatic disease (36 patients with rheumatoid arthritis, 24 patients with psoriatic arthritis and 17 patients with ankylosing spondylitis) who began with anti-TNFα (infliximab, adalimumab, etanercept). All underwent a complete neurological examination, nuclear magnetic resonance of the brain and the entire spine, and a neurophysiology study before and more than 18 months after starting the biological therapy. In the initial scrutiny, they detected lesions compatible with demyelinating disease in magnetic resonance in 2 patients and, thus, decided against the biological treatment. At the end of the study, 4% of the patients (3/75) showed evidence of neurological involvement: peripheral demyelinating neuropathy (2 patients) and optic neuritis. In each case, the biological therapy was interrupted and the neurological disease was treated. The neurological symptoms remitted in all the patients.9 The authors stress ...
Patients with inflammatory bowel disease who required abdominal surgery while on biologics did not have more postoperative complications than those whose biologic regimens were interrupted.13-15. The first study of patients with psoriasis or psoriatic arthritis on biologics enrolled 42 patients undergoing 77 different procedures.16 While patients who continued biologic therapy did not have higher rates of postoperative complications, those who did interrupt treatment found their underlying disease worsened. Most rheumatology associations recommend interrupting biologic therapy for at least 4 half-lives before scheduled major surgery; that criterion would involve going 4 to 6 weeks without infliximab, 6 to 8 weeks off adalimumab, 2 to 3 weeks off etanercept, and 12 to 25 weeks off ustekinumab before operations.17-19 The evidence supporting that recommendation, however, is weak; in fact, it is supported only by expert opinion.. The 2013 consensus statement of the Spanish Academy of Dermatology and ...
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Global Cancer Biologic Therapy Market- Forecast to 2021 The report firstly introduced Global Cancer Biologic Therapy Market including classification, appli
Biological therapy may be used to treat chronic myelogenous leukemia in the chronic or accelerated phase. Learn about biological therapy for CML.
Phage therapy or viral phage therapy is the therapeutic use of bacteriophages to treat pathogenic bacterial infections. Phage therapy has many potential applications in human medicine as well as dentistry, veterinary science, and agriculture. If the target host of a phage therapy treatment is not an animal, the term "biocontrol" (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy". Bacteriophages are much more specific than antibiotics. They are typically harmless not only to the host organism, but also to other beneficial bacteria, such as the gut flora, reducing the chances of opportunistic infections. They have a high therapeutic index, that is, phage therapy would be expected to give rise to few side effects. Because phages replicate in vivo, a smaller effective dose can be used. On the other hand, this specificity is also a disadvantage: a phage will only kill a bacterium if it is a match to the specific strain. Consequently, phage mixtures are ...
...FORT WORTH Texas June 7 2011 /- Healthpoint Biotherape...The presentations will include updates on the Companys ongoing commer... About Healthpoint Biotherapeutics ...Healthpoint Biotherapeutics is a biopharmaceutical company focused on ...,Healthpoint,Biotherapeutics,to,Present,at,Upcoming,Investment,Conferences,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Title: Phage Therapy in Clinical Practice: Treatment of Human Infections. VOLUME: 11 ISSUE: 1. Author(s):Elizabeth Kutter, Daniel De Vos, Guram Gvasalia, Zemphira Alavidze, Lasha Gogokhia, Sarah Kuhl and Stephen T. Abedon. Affiliation:Lab 1, The Evergreen State College, Olympia, WA 98505, USA.. Keywords:Bacteriophages, burn care, Eliava Institute, Hirszfeld Institute, intestiphage, osteomyelitis treatment, phage therapy, purulent infections, pyophage, wound care. Abstract: Phage therapy is the application of bacteria-specific viruses with the goal of reducing or eliminating pathogenic or nuisance bacteria. While phage therapy has become a broadly relevant technology, including veterinary, agricultural, and food microbiology applications, it is for the treatment or prevention of human infections that phage therapy first caught the worlds imagination - see, especially, Arrowsmith by Sinclair Lewis (1925) - and which today is the primary motivator of the field. Nonetheless, though the first human ...
Bacteriotherapy is the use of transplanted bacteria inside of an organism. Fecal bacteriotherapy works due to bacterial interference, the process by which bacteria displace pathogens. Bioremediation Biodegradation Microbial biodegradation van Nood, E; Vrieze, A; Nieuwdorp, M; et al. (January 2013). "Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile". N. Engl. J. Med. 368 (5): 407-15. doi:10.1056/NEJMoa1205037. PMID 23323867. Huovinen, Pentti (18 August 2001). "Bacteriotherapy: the time has come". British Medical Journal. BMJ Group. 323 (7309): 353-354. doi:10.1136/bmj.323.7309.353. PMC 1120965 . PMID 11509411 ...
Fecal bacteriotherapy Fecal microbiota transplantation (FMT) also known as a stool transplant is the process of transplantation of fecal bacteria...
This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the worlds 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the worlds 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of ...
Rectal bacteriotherapy, fecal microbiota transplantation or oral vancomycin treatment of recurrent Clostridium difficile infections: A randomized controlled trial. ...
Our Biologic Therapy Program focuses on the treatment of advanced melanoma and kidney cancer. Physicians, including Drs. Michael Atkins, David McDermott, James Mier, Rupal Bhatt, and Dan Cho, investigate and use biologic agents, such as cytokines and vaccines, to treat solid tumors in patients with metastatic melanoma and kidney carcinoma.
Title:Recent Advances in Probiotics as Live Biotherapeutics Against Gastrointestinal Diseases. VOLUME: 24 ISSUE: 27. Author(s):Rohini Krishna Kota, Ranga Rao Ambati*, Aswani Kumar Y.V.V., Krupanidhi Srirama and Prakash Narayana Reddy*. Affiliation:Department of Biotechnology, Vignans Foundation for Science, Technology and Research, Vadlamudi, Guntur-522213, Andhra Pradesh, Department of Biotechnology, Vignans Foundation for Science, Technology and Research, Vadlamudi, Guntur-522213, Andhra Pradesh, Department of Biotechnology, Acharya Nagarjuna University Nagarjuna Nagar, Guntur- 522510, Andhra Pradesh, Department of Biotechnology, Vignans Foundation for Science, Technology and Research, Vadlamudi, Guntur-522213, Andhra Pradesh, Department of Biotechnology, Vignans Foundation for Science, Technology and Research, Vadlamudi, Guntur-522213, Andhra Pradesh. Keywords:Gastrointestinal diseases, therapy, probiotics, biotherapeutics, Fecal Microbial Transplants (FMTs), Gut microbiota ...
BETHESDA, MD, January 18, 2017 - Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ("NW Bio"), a U.S. biotechnology company developing DCVax® personalized immune therapies for operable and inoperable solid tumor cancers, announced today that Dr. Marnix Bosch, Chief Technical Officer of NW Bio, will present at the Phacilitate Immunotherapy World Conference on Thursday, January 19, 2017, at the Hyatt Regency Hotel in Miami, Florida.. Dr. Bosch will chair the session entitled "New Therapeutic Approaches - Expanding the Reach of Cancer Immunotherapy to All Patients In Need of Better Treatments," taking place from 4:30 p.m. to 5:35 p.m. on Thursday, January 19, and will make a presentation on the same subject. There will not be a webcast. The presentation was originally scheduled to be made by Ms. Linda Powers, CEO of NW Bio, but she was unable to do so due to illness.. The annual Phacilitate Immunotherapy World Forum is one of the worlds largest and fastest growing senior-level immuno-oncology ...
Funding Enables Existing Clinical Trials to Proceed as Company Joins Global Response with COVID-19 Program. PITTSBURGH - May 7, 2020 - Noveome Biotherapeutics, Inc., a clinical-stage biopharmaceutical company developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues, has received a $4 Million grant from the Commonwealth of Pennsylvania to continue clinical trials of its lead product candidate, ST266, in a wide range of diseases, including multiple ophthalmic indications. The funding will enable Noveome to shift its existing resources to support the companys recently launched COVID-19 program evaluating ST266 as a treatment for the "cytokine storm"-the severe inflammatory response often observed in COVID-19 infections.. "While researchers around the world race to deliver a vaccine that will address this COVID-19 pandemic head on, we need a range of new therapeutics and diagnostics to stem the tide. This very timely funding will ...
3 Cases Substantially Completed, 4th Case Pending Completion, No Monetary Damages Contemplated. Bethesda, MD, October 24, 2017 - Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ("NW Bio"), a U.S. biotechnology company developing DCVax® personalized immune therapies for operable and inoperable solid tumor cancers, is pleased to report meaningful progress in resolving four lawsuits that were brought against it as reported in the Companys periodic filings.. All four of the lawsuits have been or are being resolved without any negative findings against the Company or its management, despite allegations of misconduct and misrepresentation, and resolved without any monetary damages. One of the cases was dismissed outright, in its entirety, by the court. Two further cases were settled after NW Bio announced the Nasdaq remediation plan on September 6, 2016 and agreed to take certain future actions to enhance its corporate governance practices. The fourth case is in the process of being settled on similar ...
...DURHAM N.C. Dec. 14 /- Oxygen Biotherapeutics...Dr. Blanck began his military career in 1968 as a medical officer and ...After his military service and prior to joining Martin Blanck & A... I am very honored that an individual with Ron Blancks combination of...,Oxygen,Biotherapeutics,,Inc.,Expands,Board,of,Directors,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Results 22 women and 8 men mainly living in urban areas (73.3%) and most of them with at least 12 years of formal education (73.3%) have been included in the study. Mean age was 56.8 (sd: 12.7) years and mean duration on biological therapy was 49 (20.2) months. In 22 cases (73.3%) patients received a new treatment because of the lack of efficacy of the previous one, in two cases it was an allergic reaction and in 6 cases (20%) an administrative reason determined this change. The aspects our patients considered as being most important when select a 2nd biologic are: the efficacy of new drug compared with the previous one, treatment schedule, the impact of new treatment on previous comorbidities, the global efficacy of new drug. On the opposite side are: the route of administration, the potential role of a health worker in drug administration, the possible financial aid (co-reimbursement) schemes. We also evaluated how deep every of these 24 aspects have been discussed with the rheumatologists at ...
Results Of the total of patients, 24/37 (64.9%) were treated with Ifx and 13/37 (35.1%) with Ada, being female 23 (62.1%). The mean age was 55.1 ± 12.3 years and the mean disease duration was 14.4 ± 9.9 years. The average time on biological therapy was 4.4 ± 3.2 years. Most patients received concomitantly classical DMARDs [29/37 (78.3%) with DMARDs vs 8/37 (21.7%) in monotherapy]. At baseline, clinical activity (DAS28) was higher in patients who subsequently not developed ADA (5.1 ± 0.9 without ADA vs 13.4 ± 0.6 with ADA, p = 0.021). Clinical activity (DAS28) tended to be higher in patients with ADA at all studied time points (5.4 ± 1.2 with ADA vs 2.8 ± 1.3 without ADA at 6 months, p = 0.007; 4.0 ± 1.2 with ADA vs 3.0 ± 1.3 without ADA at 1 year, p = 0.144; 2.9 ± 1.3 with ADA vs 2.4 ± 0.4 without ADA a, 2nd year, p = 0.169). Clinical improvement (delta-DAS28) was lower in patients with ADA throughout the study (-1.0 ± 1.6 with ADA vs 2.0 ± 1.4 without ADA at 6 months, p = 0.006, ...
Black patients receiving Medicare are less likely to receive biologic therapies for the treatment of moderate to severe psoriasis than white patients.
An update on the use of biologic therapies in the management of uveitis in Behçets disease: a comprehensive review. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Immunotherapy, or biological therapy, uses the bodys immune system to fight cancer and other diseases. Learn more about immunotherapy treatment at Virtua.
Benefits of biologic therapy for inflammatory diseases such as psoriasis, psoriatic arthritis, etc outweigh the risk for developing infections like tuberculosis, shingles, pneumonia and listeriosis.
Common side effects of biological therapies are generally similar to flu symptoms. These include fever, chills, fatigue, headache, and muscle aches. Biological therapy may also cause rash or swelling where the injection is given. Symptoms may differ, depending on the person and the therapy. Medications may be given to prevent side effects of biological therapy. Side effects usually stop when treatment is finished.. Interferon alpha may affect the bone marrow or the liver. Interleukin-2 can cause a drop in blood pressure and a build-up of fluid in your body. Yervoy™ (ipilimumab) may cause immune system side effects. All biological therapies should be used with caution based on their potential toxicities.. ...
Cancer Monthly. Lung Cancer treatments. Biologic therapy. Chemotherapy. Mount Sinai Cancer Center, Miami Beach, FL, United States. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Cancer Monthly. Breast Cancer treatments. Biologic therapy. Chemotherapy. Monash University, Clayton, Australia. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
The major growth drivers for Biologic Therapy includes the increasing pharmaceuticals industries, increasing biologic products increasing government suppor
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining different types of biolo
RATIONALE: Biological therapy using a gene-modified virus that can make interleukin-12 may help the body build an effective immune response to kill tumo
This book offers psychiatry residents and other mental health professionals an introduction to the combined use of psychological and biological therapies in managing common psychiatric disorders.