Parameter optimization is an important aspect for achieving highest accurate results. This paper investigates different parameters of the one dimensional Log-Gabor filter approach to produce optimal recognition rates. ROC curves are adopted to measure the recognition accuracy. More than 20 million matches have been performed in our experiment. Our experimental results show that optimal wavelength is linear change with the normalized length in angular direction in the polar coordinates. This paper also finds the optimal phase number for pattern encoding, and the optimal radial length ...
Abstract: Recent years have witnessed extensive research activity in modeling biological phenomena as well as in developing intervention strategies for such phenomena. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena. In this paper, two different intervention strategies, namely direct and indirect, are proposed for the S-system model. In the indirect approach, the prespecified desired values for the target variables are used to compute the reference values for the control inputs, and two control algorithms, namely simple sampled-data control and model predictive control (MPC), are developed for transferring the control variables from their initial values to the computed reference ones. In the direct approach, a MPC algorithm is developed that directly guides the target variables to their desired values. The proposed intervention strategies are applied to the ...
EONS modeling platform is a resourceful learning and research tool to study the mechanisms underlying the non-linear dynamics of synaptic transmission with the aid of mathematical models. Mathematical modeling of information processing in CNS pathways, in particular modeling of molecular events and synaptic dynamics, have not been extensively developed owing to the complex computations involved in integrating a multitude of parameters. In this paper, we discuss the development of a strategy to adapt the EONS synaptic modeling platform to a multi-node environment using a parallel computational framework to compute data intensive long simulations in a shorter time frame. We describe how this strategy can be applied to (i) determine the optimal values of the numerous parameters required for fitting experimental data, (ii) determine the impact of all parameters on various aspects of synaptic transmission (under normal conditions or conditions mimicking pathological conditions) and (iii) study the ...
A sequence of measured quantities is determined for a chemical reactor and a data generator generates a curve in normal coordinates from a respective predetermined normal form that describes a type of critical state. Each normal form is imaged onto the sequence of measured quantities by neural networks whereby a respective neural network is allocated to a data generator. The imaging is optimized by applying parameter optimization methods. The neural network that converges best through use of parameter optimization method describes the critical state that lies closest to the actual state of the chemical reactor.
In object-based image analysis (OBIA), the appropriate parametrization of segmentation algorithms is crucial for obtaining satisfactory image classification results. One of the ways this can be done is by unsupervised segmentation parameter optimi...
Abstract. As one of the drinking water sources for Xuzhou city, Yuquan River has been polluted seriously in recent years. In this paper, enhanced coagulation t
The formation of filaments from naturally occurring protein molecules is a process at the core of a range of functional and aberrant biological phenomena, such as the assembly of the cytoskeleton or the appearance of aggregates in Alzheimers disease. The macroscopic behaviour associated with such processes
In order to study a complex biological phenomenon such as tumor cell metastasis, one must focus on examining discrete aspects of the process which are amenable to experimentation. In this thesis, I made use of xenograft ...
Aging process is a biological phenomenon, which everyone has to undergo at a certain point of life. It is accentuated by a few factors, details of which are explained in the article below.
012492543X: Biochemistry, 2 Vol. Set, Metzler D.E. - |p align=justify|Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Bioche
JC just returned from two back-to-back meetings in Snowmass, CO. He presented work on small-helix partitioning in membranes at the first meeting on Free Energy Methods and structures of BamA and a new complex between SecY and a nascent chain at the second meeting on Membrane Proteins. Not all the time was spent in front of a screen though, as the picture to the right clearly shows!. ...
Fit biologically meaningful distribution functions to time-sequence data (phenology), estimate parameters to draw the cumulative distribution function and probability density function and calculate standard statistical moments and percentiles.
The work presented has highlighted the many disadvantages of parameter optimisation. Whilst significant improvements in the r.m.s.e were achieved in some areas, this was only after extensive testing and regeneration of the same model. The large number of strategy parameters used in OrthoMAX means that to test every parameter combination would be an enormous undertaking and clearly impracticable in normal circumstances. The data and results from the study prove the extreme variability of the software in certain areas, and the importance and criticality of the strategy parameters. Whilst the parameters have proved to have a significant effect in certain areas, the data has shown that manipulation of the parameters has little if any effect in areas well suited to the matching algorithm. Improvements in the accuracy of these areas are likely to be marginal through manipulation of the strategy parameters. The tests in this study were all carried out on data with checkpoint information. If this data ...
Despite recent advances in the field of image-guided interventions (IGI), the bottleneck for Angiography/X-ray guided procedures in particular is accurate and robust 2D-3D image alignment. The conventional, straight-forward parameter optimisation approach is known to be ill-posed and less efficient. Retrieval-based approaches may be of superior choice here. However, this requires salient and robust image features, which can handle the difficulties of Angiographic images such as high level of noise and contrast variance. In this paper, we investigate state-of-the-art features of the field of computer vision regarding the applicability and reliability in the challenging scenario of Angiography ...
Polymeric thin films coated on non-wettable substrates undergo film-instabilities, which are usually manifested as surface deformation in the form of dewetting or wrinkling. The former takes place in fluidic films, whereas the latter occurs in solid films. Therefore, there have rarely been reports of systems
The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena.Papers should either provide biological insight as a ...
Cocoa is a dense annotator for biological text. It annotates macromolecules, chemicals, protein/DNA parts, organisms, processes, anatomical parts, locations, physiological terms, parameters, values, experimental techniques, and foods. It should be noted that Cocoas coverage of general biological phenomena (i.e. evolution) tends to be poor. Cocoa provides a RESTful API that returns information in JSON.
At the onset of our experiments with gemcitabine in pancreatic cancer cells, we were surprised to find that there was a large inconsistency in the published results (Fig. 1B and SI Appendix, Table S1). The same cell lines in different studies were reported as sensitive or resistant, and this was true in all 15 cell lines tested. We found that differences in sensitivity depended very strongly on the cell density (Fig. 1D), and this stands as the most likely explanation for these findings and perhaps for others in drug-profiling efforts (6). Discrepancy in experimental findings is often blamed on sloppiness and has been excoriated as part of an epidemic of irreproducible scientific experiments (51). A fairer lesson is that inconsistency may reflect the extreme sensitivity of some biological phenomena to experimental conditions. History has shown that trying to resolve these can inspire discovery, as we believe has happened here. The resolution to the discrepant findings with gemcitabine is in ...
Programmed cell death or apoptosis is a widespread biological phenomenon. Apoptosis is characterized by typical cell features such as membrane blebbing, chromatin condensation, and DNA fragmentation....
Calpain represents a family of Ca(2+)-dependent cytosolic cysteine proteases found in almost all eukaryotes and some bacteria, and is involved in a variety of biological phenomena, including brain function. Several substrates of calpain are aggressively proteolyzed under pathological conditions, e.g …
Malvern MicroCal microcalorimeters enable characterization of biomolecular interactions in solution measurements of binding affinity thermodynamics and stability.
!%Plexera LLC%! has launched the PlexArray HT system, a high-throughput, label-free, surface plasmon resonance-based biomolecular interaction detecti
Pterygium is a common ocular surface disease characterized by fibrovascular invasion of the cornea and is sight-threatening due to astigmatism, tear film disturbance, or occlusion of the visual axis. However, the mechanisms for formation and post-surgical recurrence of pterygium are not understood, and a valid animal model does not exist. Here, we investigated the possible mechanisms of pterygium pathogenesis and recurrence. First we performed a genome wide expression analysis (human Affymetrix Genechip, >22000 genes) with principal component analysis and clustering techniques, and validated expression of key molecules with PCR. The controls for this study were the un-involved conjunctival tissue of the same eye obtained during the surgical resection of the lesions. Interesting molecules were further investigated with immunohistochemistry, Western blots, and comparison with tear proteins from pterygium patients. Principal component analysis in pterygium indicated a signature of matrix-related structural
Just about everyone on this planet would dearly love to honor any research scientist who can find a cure for cancer. Despite all the money and time already poured into extensive research efforts in labs and hospitals, the goal of curing this devastating clinical disease still remains elusive; about 589,000 cancer patients are expected to die from cancer in 2015 [1]. A big question thus arises, "What good is all the research and money spent on trying to conquer cancer, if a cure still has not been found after all these years?" The more you know about cancer as a biological phenomenon, the better will you be able to understand why attaining a general cure is so very, very difficult. This brief essay will teach you about the reasons for this frustrating situation that seems to damn the efforts of dedicated researchers in both basic and clinical science.. A brief background of essentials about cancer. At its most fundamental level, the biological phenomenon of cancer takes place in our cells. All ...
Just about everyone on this planet would dearly love to honor any research scientist who can find a cure for cancer. Despite all the money and time already poured into extensive research efforts in labs and hospitals, the goal of curing this devastating clinical disease still remains elusive; about 589,000 cancer patients are expected to die from cancer in 2015 [1]. A big question thus arises, "What good is all the research and money spent on trying to conquer cancer, if a cure still has not been found after all these years?" The more you know about cancer as a biological phenomenon, the better will you be able to understand why attaining a general cure is so very, very difficult. This brief essay will teach you about the reasons for this frustrating situation that seems to damn the efforts of dedicated researchers in both basic and clinical science.. A brief background of essentials about cancer. At its most fundamental level, the biological phenomenon of cancer takes place in our cells. All ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cad Dynamic Freeware - Free Software Listing (Page3). Companion Software for the Dynamic Modeling and Control of Engineering Systems, 2e book by J. This book starts with a review of parameter optimization and then treats dynamic optimization, first with fixed final time and no constraints, next with terminal contraints, and finally with terminal constraints and open final time.
CHANG Hung-Jen , FREEMAN Walter J. , BURKE Brian C. Neural networks : the official journal of the International Neural Network Society 11(3), 449-466, 1998-04-01 参考文献21件 被引用文献1件 ...
Recent advances in the use of plasmonic metamaterials to improve absorption of light in thin-film solar photovoltaic devices has created a demand for a scalable method of patterning large areas with metal nanostructures deposited in an ordered array. This article describes two methods of fabricating ordered 2D nanosphere colloidal films: spin coating and interface coating. The two methods are compared and parameter optimization discussed. The study reveals that: ...
Lipids are a different and ubiquitous cluster of compounds having key biological functions like structural constituents of cell membranes, aiding as energy storage bases and play a part in cell signaling pathways. Compound research in structural diversity of lipids benefits developments in the field of membrane lipids which in turn explains biological phenomena at the nanoscale sphere. Multiple roles can be performed by Phospholipids in cells by creating the permeability blockade for cells and cell organelles and by providing the matrix for the association and utility of a wide diversity of catalytic developments, also by substitute as donors in the production of macromolecules, and by keenly inducing the functional properties of membrane-associated developments.. ...
If you have a question about this talk, please contact Lorena Escudero.. Location matters in biology. Both the inner workings of tissues and organs and their dysregulation, which leads to disease, depend on the tight web of relationships between different cell populations, and on the concerted regulation of their function mediated by genetic and environmental effects. In the last 10 years and more, it has become clear that many biological phenomena cannot be studied by analyzing cells in bulk and outside of their natural environment, but their underlying mechanisms can only be mechanistically investigated if observed both at the single-cell level and in situ. While technologies allowing either the former or the latter of these features are now available, combining both is extremely challenging, at least with the throughput necessary to obtain reliable results. In our laboratory, we have recently launched a project, named IMAXT (Imaging and Molecular Annotation of Xenografts and Tumours), that ...
Location matters in biology. Both the inner workings of tissues and organs and their dysregulation, which leads to disease, depend on the tight web of relationships between different cell populations, and on the concerted regulation of their function mediated by genetic and environmental effects. In the last 10 years and more, it has become clear that many biological phenomena cannot be studied by analyzing cells in bulk and outside of their natural environment, but their underlying mechanisms can only be mechanistically investigated if observed both at the single-cell level and in situ. While technologies allowing either the former or the latter of these features are now available, combining both is extremely challenging, at least with the throughput necessary to obtain reliable results. In our laboratory, we have recently launched a project, named IMAXT (Imaging and Molecular Annotation of Xenografts and Tumours), that aims to produce a comprehensive tri-dimensional map of breast tumours in ...
Bioengineering applies engineering principles and methodologies to biological and medical sciences to better understand biological phenomena, to devel...
A STRESSFUL life in the womb is known to affect adult behaviour in both animals and humans. But stress is a complex biological phenomenon, so scientists have found it hard to pin down the mechanism for this link. Now a team of researchers in France says that the stress hormone corticosterone is to blame. They …
Transcription factor NF-κB: Nuclear factor κB (NF-κB) was initially identified as a transcription factor that binds to the κ-light-chain-enhancer of immunoglobulins expressed selectively in B cells, but it has since been shown to be expressed by almost all cells, including the cells of invertebrates, such as urchins and fruit flies, as well as higher animals. In mammals in particular, five molecules that belong to the NF-κB family, also called as the Rel family, are known. Members of the NF-κB family are involved in various biological phenomena, such as the immune response and cell viability, through induction of expression of inflammatory cytokines, antiapoptotic factors, etc. In addition, NF-κB activation is dysregulated in various diseases, including inflammatory and autoimmune diseases, and cancer, and attention is therefore being given to NF-κB as target molecules for treatment of various diseases ...
We use the tools of Structural Biology to investigate the key biomolecular interactions that underpin the molecular mechanisms of life and disease.. Read More ». ...
Mathematical Problems in Engineering is a peer-reviewed, Open Access journal that publishes results of rigorous engineering research carried out using mathematical tools. Contributions containing formulations or results related to applications are also encouraged. The primary aim of Mathematical Problems in Engineering is rapid publication and dissemination of important mathematical work which has relevance to engineering. All areas of engineering are within the scope of the journal. In particular, aerospace engineering, bioengineering, chemical engineering, computer engineering, electrical engineering, industrial engineering and manufacturing systems, and mechanical engineering are of interest. Mathematical work of interest includes, but is not limited to, ordinary and partial differential equations, stochastic processes, calculus of variations, and nonlinear analysis.
Most loaches will eat these snails. Whilst the Clown Loach is the most often quoted as doing this function it can grow quite large. If you want a smaller fish there are several species of loaches (like the Zebra Loach, Pakistan loach (Yo Yo)) that remain under 4" in length and will eat the snails when small. Puffers like the Ceylon Puffer will eat any type of snail once it grows bigger enough ...
In collaboration with the Theoretical and Computational Biophysics Group at the University of Illinois, we will be hosting a workshop on using computational techniques to simulate and analyze biological systems. The focus of the workshop is on the programs NAMD and VMD, developed by the TCB Group. The workshop will be from Nov. 3 - 7 on the Georgia Tech campus. More information can be found here: http://www.ks.uiuc.edu/Training/Workshop/Atlanta2014/. ...
Purpose : The development of stem cell-derived retinal organoid systems has opened previously unimaginable possibilities for the study and potential treatment of retinal degenerative diseases. However their variability and the lack of high throughput platforms for their analysis pose severe limitations for their use in drug development applications. Hence, the purpose of this work was to develop a platform (3D- ARQ) that enables fluorescence quantification-based large-scale drug screening in complex human iPSC-derived retinal organoids, while providing the speed, sensitivity and reproducibility necessary for this kind of assays. Methods : Transgenic hiPSC lines harboring GFP or YFP fluorescent reporters were generated and induced to differentiate into retinal organoids. Wild type retinal organoids were stained with various fluorescent dyes and used for parameter optimization purposes. Non-stained organoids were used as controls in all experiments. Organoids were seeded into v-bottom 96 well ...
Offered as CHEM 408 and BCBP 408.) This advanced seminar will focus on the ways in which chemical approaches have been used to study and engineer biological systems. We will explore a series of case studies in which the tools of chemistry have been brought to bear on biological questions and seek to answer the following: Did the application of small molecules that were designed and synthesized by chemists allow the researchers to elucidate biological phenomena that would have remained opaque using genetic and biochemical approaches? Do the findings suggest further experiments? If so, could follow-up experiments be carried out with known techniques, or would development of further chemical tools be required? Topics will include: the design and synthesis of chemical modulators of gene expression, signal transduction, and protein-protein interactions; chemical approaches to protein engineering and drug-target validation; activity-based proteomics; and chemical tagging of biomolecular targets. ...
Compugen discovers novel drug targets through a unique, predictive, computational process. We call this process "Predictive Discovery" because our in silico findings predict the biological function and therapeutic relevance of novel proteins which were not previously considered as drug target candidates. For over a decade, we have been developing predictive platforms for a variety of biological processes and phenomena, that are continuously being improved and diversified to address the need for novel targets in areas of interest to the industry.. Biological knowledge: For each biological phenomenon or process, we first screen the available biological literature on the topic. Our scientists study and critically evaluate the publically available information to discern the key components from a computational perspective.. Genome and proteome analysis: The genome is the most complex encryption system known to mankind, and Compugens discovery team has made exceptional progress in understanding and ...
Climate Model Problems: III. Deserts: Whereas climate models based solely on physical and chemical phenomena predict that earths deserts will expand as the airs CO2 content rises, it is found that including the effects of two biological phenomena reverses the predicted trend and suggests that the total area of earths deserts will actually decline as CO2 accumulates in the atmosphere.. Medieval Warm Period Record of the Week ...
If you have a question about this talk, please contact Fiona Roby.. Sentient creatures are ones that have a capacity for feeling; they have the potential to suffer and it is valid to be concerned about their well-being. But the problem with sentience is that it is difficult and problematic to make assumptions about. If we assume that a particular species is sentient, we can be accused of being unparsimonious in our explanations of its behaviour and anthropomorphic in our inferences. If we assume that it isnt, we may find ourselves denying the moral status of an ethically relevant being. In this talk I argue that one pragmatic assumption can and should be made about sentience - that it evolved. Taking this simple step allows us to think about sentience as a biological phenomenon that is present in humans and is likely to have antecedents in other animal species. Even if a completely human-like sentience is not a part of the biological make up of many animals, facets of sentience may be present, ...
A person with pain often asks whether or not pain can be measured and whether pain should be discussed with a physician. To answer this question, its very important to understand that although pain is a natural, biological phenomenon without which a person could not survive, when pain is acute and severe or pain becomes chronic, theres no biological advantage.
We begin from reviewing two concepts, motility in living systems, and active matter (also known as active materials). The main part of the talk is concerned with PDE models of two specific types of active matter: (i) suspensions of swimming bacteria and (ii) active gels that are networks of cross linked filaments subjected to action of energy transducing molecular motors. First we present a brief review of our past work on bacteria swimming in Newtonian fluids and current work in progress of bacteria swimming in liquid crystals. These has been preformed in a close collaboration with experimental group of I. Aronson, who will present a talk on this subject. Next we consider PDE models of motility of eukaryotic cells on a substrate. Our goal is to capture mathematically the key biological phenomena such as steady motion with no external stimuli and spontaneous breaking of symmetry. To this end we study two models of the cells cytoskeleton (active gel): the phase-field model and the free boundary ...
Background Bistability underlies basic biological phenomena, such as cell division, differentiation, cancer onset, and apoptosis. So far biologists identified two necessary conditions for bistability:...
What are the molecular principles of recognition and regulation that underlie such complex biological phenomena? Our attention currently focuses on a pair of molecular adapters - the signal recognition particle (SRP) and the SRP receptor (SR) - that deliver newly synthesized proteins to particular membrane systems within the cell. This process is responsible for the sorting of all the ER resident and secretory proteins within the cell (accounting for roughly one third of cellular proteins) and is essential to establish and maintain the amazing degree of order and organization required to sustain life. ...
NYU School of Medicines Molecular Biophysics PhD Training Program focuses on the molecular mechanisms of a wide array of biological phenomena.
Microfluidic, Devices, Microfluidic Devices, Cell, Cells, Lead, Adsorption, Biotechnology, Concentration, Concentrations, Dyes, Fluorescent Dyes, Glass, Hydrophobicity, Polymer, Polystyrene, Porosity, Time, Antibodies, Biological Phenomena
Surely once you publish a DNA sequence it becomes part of the public domain, and anybody can use it in a manner they see fit (eg. phylogenetic analysis), as long as they cite their source - otherwise there appears to be no point in publishing sequences in the first place. DNA sequence data are no different in this regard from descriptions of morphological characters, being simply observations of tangible biological phenomena. ******************************************************************************* Andrew Mitchell Department of Entomology E-MAIL: moths at phelix.umd.edu University of Maryland College Park, MD 20742 U.S.A ...
According to the beliefs of some scientists (I. S. Shklovsky), life on our planet began approximately 4-4,5 billion years ago. Due to a number of features of development of the Land during the period of its existence has created favorable conditions for the formation of complex organic belkooptorg and other high-molecular compounds in the primary atmosphere (under the influence of electric discharges) and in the water that covered much of the planet (ultraviolet rays). These organic substances, consisting mainly of carbon, hydrogen, oxygen, nitrogen, and many other chemical elements contained in the oceans in large numbers (their concentration in some settlements reached 1%). Their main feature was the ability to retain their chemical composition and physical properties when interacting with countless different chemicals with which they come into contact. This ability was provided education at first very primitive systems - koatservatov it. "The emergence of such systems is not something ...
Howle LE, Weber PW, Vann RD, Campbell MC. Marginal DCS events: their relation to decompression and use in DCS models. J Appl Physiol 107: 1539-1547, 2009. First published August 20, 2009; doi: 10.1152/japplphysiol.00185.2009.-We consider the nature and utility of marginal decompression sickness (DCS) events in fitting probabilistic decompression models to experimental dive trial data. Previous works have assigned various fractional weights to marginal DCS events, so that they contributed to probabilistic model parameter optimization, but less so than did full DCS events. Inclusion of fractional weight for marginal DCS events resulted in more conservative model predictions. We explore whether marginal DCS events are correlated with exposure to decompression or are randomly occurring events. Three null models are developed and compared with a known decompression model that is tuned on dive trial data containing only marginal DCS and non-DCS events. We further investigate the technique by which ...
NAMD is a production molecular dynamics application for biomolecular simulations that include assemblages of proteins, cell-membranes and water molecules. NAMD has demonstrated its performance on several parallel computer architectures. In a biomolecular simulation, the problem-size is fixed and a large number of iterations need to be executed to understand interesting biological phenomenon. Hence we need MD applications to scale to thousands of processors, even though the individual time step available for parallelization is quite small. The Blue Gene/L machine has tens of thousands of embedded Power PC 440 processors. In this paper, we present the challenges we had to overcome to get good sequential performance on the embedded 440 core, by the use of various compiler optimization techniques that use SIMD instructions. We also present several techniques to scale NAMD to 20,480 nodes of Blue Gene/L. These include topology specific optimizations to localize communication, new messaging protocols ...
Trait" is a ubiquitous term in biology, but its precise meaning and theoretical foundations remain opaque. After distinguishing between "trait" and "character," I argue for the value of adopting Theodosius Dobzhanskys 1956 definition and framework for understanding "trait," which holds that traits are just "semantic devices" that artificially impose order on continuous biological phenomena. I elaborate on this definition to distinguish between trait validity (compliance with Dobzhanskys trait definition) and trait utility (usefulness of a trait). As a consequence of this elaboration of the meaning of "trait," it becomes clear that considerations of adaptation, function, homogeneity and natural kinds have clouded discussions of the meaning of "trait" per se. Combining this account with work by David Hull and examples from contemporary biology, I demonstrate that even broad or heterogeneous traits (including multiple sub-traits) can qualify as valid and useful. As a test case for this ...
Molecular Life Sciences: An Encyclopedic Reference will focus on understanding biological phenomena at the level of molecules and their interactions that govern life processes.
What makes a living system a living system? What kind of biological phenomenon is the phenomenon of cognition? These two questions have been frequently considered, but, in this volume, the authors, Humberto Maturana and Francisco Varela, consider them as concrete biological questions. Their analysis is bold and provocative, for the authors have constructed a systematic…
Author Summary Recent technology has made it possible to do experiments that show hundreds or even thousands of genes that play a role in a disease or other biological phenomena. Interpreting these experimental results in the light of everything that has ever been published about any of those genes is often overwhelming, and the failure to take advantage of all prior knowledge may impede biomedical research. The computer program described in this paper
Among vertebrate species of the major vertebrate classes in the wild, a seasonal rhythm of whole body fuel metabolism, oscillating from lean to obese condition, is a common biological phenomenon. This annual cycle is driven in part by annual changes in the circadian dopaminergic signaling at the suprachiasmatic nuclei (SCN), with diminution of circadian peak dopaminergic activity at the SCN facilitating development of the seasonal obese insulin resistant condition. The present study investigated whether such an ancient circadian dopamine-SCN activity system for expression of the seasonal obese, insulin resistant phenotype may be operative in animals made obese, insulin resistant by high fat feeding and if so whether reinstatement of the circadian dopaminergic peak at the SCN would be sufficient to reverse the adverse metabolic impact of the high fat diet without alteration of caloric intake ...
What doesnt kill a bug sometimes makes it stronger…or bigger, or longer lived, or able to lay lots and lots of eggs. This biological phenomenon is ca...
The MicroCal PEAQ-ITC is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10µg sample. Semi-automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal PEAQ-ITC Automated, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.. ...
Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.
Thin films play an important role in nature and many areas of technological applications. In particular on micro- and nanoscales technological processes such as dewetting or epitaxial growth are used to design surfaces with specific material properties. Apart from the need to derive mathematical decriptions, analyis and numerical simulation, that serve to accelerate the development of new technologies, it is also exciting to understand material behaviour on these small scales.. ...
Computational Intelligence and Neuroscience is a forum for the interdisciplinary field of neural computing, neural engineering and artificial intelligence, where neuroscientists, cognitive scientists, engineers, psychologists, physicists, computer scientists, and artificial intelligence investigators among others can publish their work in one periodical that bridges the gap between neuroscience, artificial intelligence and engineering.
We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide-protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. Their utility as a tool for detecting specific biomolecular interactions has not been explored. Using the well characterized p53-Mdm2 interaction as a model system, we designed a 9-(2-carboxy-2-cyanovinyl) julolidine-based p53 peptide reporter, JP1-R, which fluoresces conditionally only upon Mdm2 binding. The reporter was used in a rapid, homogeneous assay to screen a fragment library for antagonists of the p53-Mdm2 interaction, and several inhibitors were identified. Subsequent validation of these hits using established secondary assays suggests increased sensitivity afforded by JP1-R. The fluorescence of molecular rotors contingent upon target binding makes them ...
We demonstrate the use of fluorescent molecular rotors as probes for detecting biomolecular interactions, specifically peptide-protein interactions. Molecular rotors undergo twisted intramolecular charge transfer upon irradiation, relax via the nonradiative torsional relaxation pathway, and have been typically used as viscosity probes. Their utility as a tool for detecting specific biomolecular interactions has not been explored. Using the well characterized p53-Mdm2 interaction as a model system, we designed a 9-(2-carboxy-2-cyanovinyl) julolidine-based p53 peptide reporter, JP1-R, which fluoresces conditionally only upon Mdm2 binding. The reporter was used in a rapid, homogeneous assay to screen a fragment library for antagonists of the p53-Mdm2 interaction, and several inhibitors were identified. Subsequent validation of these hits using established secondary assays suggests increased sensitivity afforded by JP1-R. The fluorescence of molecular rotors contingent upon target binding makes them ...
The work described in this thesis involves the application of direct real-time biomolecular interaction analysis using existing SPR-based biosensors and the development of novel alternative SPR-based technologies. These systems were applied to the investigation of whole cell binding to an immobilised ligand. Solid-phase blood typing was demonstrated by employing monoclonal anti- A IgG and anti-B IgM as affinity ligands for the capture of washed whole red blood cells (RBC). Protein A affinity-capture of anti-A IgG was used as an alternative to direct immobilisation thereby facilitating surface regeneration. A new non-real-time fibre optic-based system (BIACORE Probe) was evaluated using the same affinity-capture format and was successfully applied to direct whole blood typing. Non-real time analysis limited the data quality. Therefore, a similar real-time fibre optic device was constructed. In addition, a miniature SPR-based biosensor employing a single platform optical configuration was ...
Super-resolution optical fluctuation imaging (SOFI) allows one to perform sub-diffraction fluorescence microscopy of living cells. By analyzing the acquired image sequence with an advanced correlation method, i.e. a high-order cross-cumulant analysis, super-resolution in all three spatial dimensions can be achieved. Here we introduce a software tool for a simple qualitative comparison of SOFI images under simulated conditions considering parameters of the microscope setup and essential properties of the biological sample. This tool incorporates SOFI and STORM algorithms, displays and describes the SOFI image processing steps in a tutorial-like fashion. Fast testing of various parameters simplifies the parameter optimization prior to experimental work. The performance of the simulation tool is demonstrated by comparing simulated results with experimentally acquired data.. ...
http://cran.r-project.org/web/packages/aphid. Designed for the development and application of hidden Markov models and profile HMMs for biological sequence analysis. Contains functions for multiple and pairwise sequence alignment, model construction and parameter optimization, file import/export, implementation of the forward, backward and Viterbi algorithms for conditional sequence probabilities, tree-based sequence weighting, and sequence simulation. Features a wide variety of potential applications including database searching, gene-finding and annotation, phylogenetic analysis and sequence classification.. Maintainer: Shaun Wilkinson ...
Advances in such fields as proteomics and genomics place new demands on students and professionals to be able to apply quantitative concepts to the biological phenomena that they are studying. Spectroscopy for the Biological Sciences provides students and professionals with a working knowledge of the physical chemical aspects of spectroscopy, along with their applications to important biological problems ...
Bioengineering combines the analytical and experimental methods of the engineering profession with the biological and medical sciences to achieve a more detailed understanding of biological phenomena and to develop new techniques and devices. The engineers quantitative and analytical approach; traditional competence in the processing and control of information, energy, and materials; and ability to design and analyze systems are powerful tools when applied to biology, medicine; and …
My name is Clemente Aguilar and I love science. I am a postdoctoral fellow at the National Institute for Mathematical and Biological Synthesis (NIMBioS) and my way to understand biological phenomena is by mixing knowledge from the areas of biology, statistics, and computer programming. In the past I have worked in the development of computational methods for mass spectrometry data analysis, particularly in the identification of glycolipids and proteins. Most recently I have become interested in anything related with the immune system; specifically my current research is focused on developing efficient algorithms for epitope prediction ...
This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including ... More. This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including humans). The scope extends beyond the target organism to consider the ecosystem-level dynamics of migration. Rather than simply reviewing the field of migration as it stands today, the book highlights the lacunae in our knowledge and understanding. The emphasis is on exciting new research avenues that are now opening up, whether because of advances in our understanding of migration as a biological phenomenon or through the availability of a range of new technologies. Broad themes that emerge include smoothly integrating migration into the broad spectrum of movement behaviour; the need for a comparative ...
This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including ... More. This book takes a comparative, integrated view of migration, linking evolution with ecology and management, theory with empirical research, and embracing all the major migratory taxa (including humans). The scope extends beyond the target organism to consider the ecosystem-level dynamics of migration. Rather than simply reviewing the field of migration as it stands today, the book highlights the lacunae in our knowledge and understanding. The emphasis is on exciting new research avenues that are now opening up, whether because of advances in our understanding of migration as a biological phenomenon or through the availability of a range of new technologies. Broad themes that emerge include smoothly integrating migration into the broad spectrum of movement behaviour; the need for a comparative ...
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.[138] Model organisms are in vivo models and are widely used to research human disease when human experimentation would be unfeasible or unethical.[139] This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution.[140] Studying model organisms can be informative, but care must be taken when extrapolating from one organism to another.[141]. In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming a human. The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resembles human ...
Chai, J., Shiozaki, E., Srinivasula, S. M., Wu, Q., Datta, P., Alnemri, E. S., Shi, Y., Dataa, P. (2001). Structural basis of caspases-7 inhibition by XIAP. Cell. 104:769-780 El-Deiry, W. S., Jin, Z. (2005). Overview of cell death signalling pathways. Cancer biology and therapy. 4(2):139-163 Fadeel, B., Orrenius, S. (2005). Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. Journal of internal medicine. 258:479-517 Fischer, U., Schulze-Osthoff, K. (2005). Apoptosis-based therapies and drug targets. Cell death and differentiation. 12:942-961 Gewies, A. (2003). Introduction to apoptosis. Aporeview. 1-26 Mazumder, S., Plesca, D., Almasan, A. (2005). Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods in molecular biology. 414:13-21 Ranger, A. M., Malynn, B. A., Korsmeyer, S. J. (2001). Mouse models of cell death. Nat genet. 28:113-118 Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., ...
This course will explore a diverse collection of striking biological phenomena associated with the X chromosome. We will examine the genetic basis and
Unique coherent compendium of the theoretical underpinnings of thin film dynamics, in particular their instabilities Presents a large range of
A method for processing image data includes estimating initial factor images from image data, transforming the estimated initial factor images by a transformation variable to obtain transformed factor images, providing an objective function that is a function of the transformed factor images, and minimizing the objective function to obtain unique factor images from the estimated initial factor images.
The paper presents simulation studies targeting high-power narrow-linewidth emission from semiconductor distributed feedback (DFB) lasers. The studies contain analytic and numerical calculations of emission linewidth, side mode suppression ratio and output power for DFB lasers without phase shifts and with 1 × λ/ 4 and 2 × λ/ 8 phase shifts, taking into account the grating and facets reflectivities, the randomness of the spontaneous emission and the longitudinal photon and carrier density distributions in the laser cavity. Single device structural parameter optimization is generally associated with a trade-off between achieving a narrow linewidth and a high output power. Correlated optimization of multiple structural parameters enables the evaluation of achievable ranges of narrow linewidth and high power combinations. Devices with long cavities and low grating coupling coefficients, κ (keeping κL values below the levels that promote re-broadening), with AR-coated facets and with a ...
M. Amin, Sri Yulis and Jamaludin, Khairur Rijal and Muhamad, Norhamidi (2009) Rheological properties of SS316l MIM feedstock prepared with different particle sizes and powder loadings. The Journal of the Institution of Engineers, Malaysia, 7 (2). pp. 59-63. ISSN 0126-513X Mazlan, Khalid (Penyelenggara) (2009) Gaya & panduan penerbitan book chapters. Penerbit UTM, Skudai, Johor Bahru. ISBN 978-983-52-0703-7 Md. Zain, Ahmad Rifqi (2009) One - dimensional photonic crystal/photonic wire cavities based on silicon - on - insulator (SOL). PhD thesis, University of Glasgow. Mohamad, Khairul Azmi and Othman, Nooraini (2009) Nilai yang mendasari integriti dan amalan masyarakat hadhari. In: Ke Arah Umat Hadhari. Yayasan Ilmuwan, Kuala Lumpur, Malaysia. ISBN 978-983-44372-1-3 Mohamad Nor, Nor Hafiez and Muhamad, Norhamidi and Ismail, M. H. and Jamaludin, Khairur Rijal and Ahmad, S. and Ibrahim, M. H. I. (2009) Injection molding parameter optimization of titanium alloy powder mix with palm stearin and ...
As a graduate student in physics, I recognized the immense opportunities offered by using physical methods and physics-based approaches to study biological function. At the time, I became intrigued by the complexity of biological phenomena, and was captivated by the challenges of reducing this complexity to basic physical principles at the molecular level. I was impressed by advances in structural and computational biology, based largely on physical techniques, that enabled us to look intimately into three-dimensional structures of biological molecules and study forces that keep structures together, influence biomolecular dynamics, and drive biomolecular interactions. As time passed, I developed an appreciation for pathways and networks within and between cells, tissues, organs, and organisms, as well as for bioengineering applications based on biophysical studies.. Why did you decide to get involved with publishing?. Scientific research and publication are interweaved. Publication is the only ...
This dataset contains the digitized treatments in Plazi based on the original journal article Pérez-González, Abel, Sharma, Prashant P., Proud, Daniel N. (2016): Morphological tricks and blessed genitalia: rectifying the family placement of Fijicolana tuberculata (Opiliones: Laniatores: Zalmoxidae). Zootaxa 4061 (3): 253-260, DOI: http://doi.org/10.11646/zootaxa.4061.3.3 ...
The new theoretical physics and statistical mechanics group at Universite Montpellier II in Montpellier, France is seeking candidates for 1 PhD student position (3 years - start: September/October 2012) and 1 postdoctoral fellow position (1 year + possibilities for extension - start: Fall-Winter 2012-2013). Topics to be studied include: i) motor protein dynamics in intracellular phenomena; ii) non-equilibrium classical transport at molecular scales; iii) collective transport phenomena on complex networks; and iv) interface theory/experiments. Candidates profile: interest for analytical/numerical approaches in biophysics and theoretical physics inspired by biological phenomena, statistical mechanics, stochastic processes, nonlinear phenomena. Contact Prof. Andrea Parmeggiani at [email protected] ...
2016. Grulich M, Brezovsky J, Stepanek V, Palyzova A, Maresova H, Zahradnik J, Kyslikova E, Kyslik P, 2016: In-silico Driven Engineering of Enantioselectivity of a Penicillin G Acylase towards Active Pharmaceutical Ingredients. Journal of Molecular Catalysis B: Enzymatic 133: S53-S59. full text.. Brezovsky J,* Babkova P,* Degtjarik O, Fortova A, Gora A, Iermak I, Rezacova P, Dvorak P, Kuta Smatanova I, Prokop Z, Chaloupkova R, Damborsky J, 2016: Engineering a De Novo Transport Tunnel. ACS Catalysis 6: 7597-7610. full text Marques SM, Daniel L, Buryska T, Prokop Z, Brezovsky J, Damborsky J, 2016: Enzyme Tunnels and Gates as Relevant Targets in Drug Design. Medicinal Research Reviews 37: 1095-1139. full text. Bendl J, Musil M, Stourac J, Zendulka J, Damborsky J,# Brezovsky J,# 2016: PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions. PLoS Computational Biology 12: e1004962. full text. Bendl J, ...
This meeting united participants from the fields of experimental epigenetics, mathematics and computational biology, to discuss results and challenges in the endeavour to explore points of synergy between these fields. The design shown here expresses the idea of moving complex biological phenomena (left nucleosome) towards precise mathematical descriptions (right nucleosome). ...
Our group is interested in using computers to understand biological phenomena, via data analysis, modelling and prediction. Our main focus at present is on the area of quantitative proteomics: how can we measure the levels of all the individual proteins in cells and tissues, and understand how these levels change in different conditions, as well as under stress. We are working on methods to do this in collaboration with mass spectrometrists and protein chemists, developing software for experimental design and downstream analysis of results, using yeast and the fruit fly as model systems. In parallel, we are analysing experimental RNA sequencing data in yeast to understand how cells regulate the translation of mRNA in to proteins, a fundamental process of molecular biology which is now know to play a significant role in the regulation of gene expression, particularly under stress conditions.. ...
For our final project, we chose to help Quentin organize some information that he had been acquiring for his preliminary exam. At first, Emily and Kate had little idea what Quentins project was on. Quentin was quoted to say "Glycosyltransferase…it puts sugars on lots of stuff". To unravel the mystery surrounding this enzyme, the trio worked together with a few tools that were learned during this weeks workshop.. Wordle: Generation of the wordle showed key words and phrases that hinted at the functioning of this enzyme. We used the first paragraph from wikipedia to create this wordle. End-note: The main method that Quentin used to organize his literary resources was End-Note. Emily and Kate created accounts so they could have access to the journal articles. We found that EndNote was a great tool to not only organize resources but to create in-text citations and bibliographies. Some of the journal articles listed above pointed out how glycolsylation is a pivotal biological phenomena that allows ...
Adenosine, Forebrain, Sleep, Eeg, Rats, Sleep Deprivation, Neurons, ATP, Brain, Eye, Eye Movement, Movement, Rapid Eye Movement, Membrane, Nitric Oxide, Wakefulness, Time, AMP, Amp-activated Protein Kinase, Biological Phenomena
In life, timing is everything. There is a new buzzword in cancer therapy, Chronobiology. Simply put, this means the study of clocklike stuff in living things. Or you can use the brainier definition, Chronobiology is the quantitative study of rhythmic temporal relationships in biological phenomena. Our bodies go through a day as if multiple clocks were hardwired into our brains, organs, and very cells telling us what to do and when to do it. In recent years scientists have just begun to understand these multiple rhythms of activity and rest that different systems in the body go through on a daily basis. These daily, or circadian, cycles repeat themselves every 24 hours. Cells dont grow at a constant rate; rather there are bursts of frantic cell division followed by rest spells. Hormones are not generated at a steady flow rate but have high points when they are dumped into the blood and low points throughout the day. All animals have built in clocks in not just their bodies but in their ...
As if that werent enough, from time to time I get an email with a photo of some biological oddity or other (usually something I cant myself identify). This photo in particular caught my eye. One, because it is truly strange, and 2) because it represents one of the coolest and weirdest biological phenomena I know.. The strange plant part in the photo is called a gall. A gall is a structure that a plant creates, not of its own accord, but after being induced to do so, usually by an insect or a mite. The animal injects a particular chemical into the plant, and the plant responds by growing a very distinctive, protective structure that provides shelter to the animal. Often, the galls are also filled with nutritious starch, feeding the growing larvae as well as housing it.. This particular gall was found on a Sitka spruce, and is known as a Cooley spruce gall. In it lives the larvae of a spruce adelgid, and insect much like an aphid. The galls are induced generally on the new growth of the trees, ...
AMHERST, Mass. -- Scoffing at or cutting funds for basic biological research on unusual animal adaptations from Gila monster venom to snail sex, though politically appealing to some, is short-sighted and only makes it more likely that important economic and social benefits will be missed in the long run, say a group of evolutionary biologists at the University of Massachusetts Amherst.. Writing in a recent issue of BioScience, researchers Patricia Brennan, Duncan Irschick, Norman Johnson and Craig Albertson argue that "innovations often arise from unlikely sources" and "reducing our ability to creatively examine unique biological phenomena will ultimately harm not only education and health but also the ability to innovate, a major driver of the global economy.". First author Brennan, known for her duck genitalia studies that could eventually aid human medical science points out, "Basic science has increasingly come under attack, and there is a growing perception that studying odd science ideas ...
The MAMBE curriculum is founded on the idea that interdisciplinary thinking enhances in-depth understanding of biological phenomena. For example, the complexity that are characteristic for many molecular processes can often only be understood by taking into account their evolutionary origin. Similarly, the evolution of particular trait functions may also often depend on the underlying molecular mechanisms. MAMBE will foster such interdisciplinary connections. In the first two semesters, you will learn about the basic mechanisms and processes of molecules and evolution. Additionally, you will enhance your skill set in scientific communication and management (e.g., preparation of seminar talks, or writing of grant applications, etc). During the third semester, the acquired competences will be applied to real research life in the laboratory and field. The fourth semester will consist of your Master thesis.. ...
Click here to receive the Jeff Zeig show guide! Stages of Love: Love is a biological phenomenon that has three different stages, each with their own neurobiology. The first is the Stage of Attraction; this is when we discover someone who we feel drawn to. The next is the Stage of Attachment; this is a stage of luminance, which is marked with high sexual activity, an intense desire to find similarities, and a sense that you cannot get enough of each other. This stage then evolves into the Bonding stage in which we choose our partner as our mate. At this stage the neurochemicals secreted naturally drive down sexual desire. This decrease in dopamine rich sexual activity can become a crisis for couples who do not understand that there is a biological context influencing this change and instead create stories of lost connection or attraction.. Shakespeare was right- love is blind. In the luminance stage we are nearly incapable of seeing our partner for who they truly are. In fact, we see them through ...
Author Summary Coevolution between hosts and parasites is believed to be central to a number of biological phenomena, most notably the observed patterns of biodiversity and the origins of sexual reproduction. However, classical mathematical models of host-parasite coevolution account neither for the hosts use of bacterial symbionts for protection from parasites, nor for the potential and observed complexity of genetic interactions between the coevolving species. In this article we address both challenges by simulating a large number of models of host-symbiont-parasite coevolution based on randomly generated genotype interaction patterns. We demonstrate that the degree of
Colorectal tumors originate and develop within intestinal crypts. Even though some of the essential phenomena that characterize crypt structure and dynamics have been effectively described in the past, the relation between the differentiation process and the overall crypt homeostasis is still partially understood. We here investigate this relation and other important biological phenomena by introducing a novel multiscale model that combines a morphological description of the crypt with a gene regulation model: the emergent dynamical behavior of the underlying gene regulatory network drives cell growth and differentiation processes, linking the two distinct spatio-temporal levels. The model relies on a few a priori assumptions, yet accounting for several key processes related to crypt functioning, such as: dynamic gene activation patterns, stochastic differentiation, signaling pathways ruling cell adhesion properties, cell displacement, cell growth, mitosis, apoptosis and the presence of ...
Its easy to brush Qi under the table as laughable prescientific vitalism, but one should keep it firmly in mind that this concept is actually one of the things that tends to attract people to alternative views. As its used in TCM, it is totally vitalism: I grant that without the slightest reservation or hesitation. But, there is an empirical phenomenon here that you shouldnt overlook, which has a very strong amount of sway on people. I know that statement will sound immediately woo-y, but please allow me to elaborate.. Qi comes out of a culture that made a series of observations about biological phenomena but lacked any sort of framework of names to grant to those observations or to explain how those observations related to one another. There was no theory of cells, no notion of hormones and certainly no practical concept of nerves or any microscopic structures, but they did have observations about their bodies that they needed to some catch-all term to identify. In China, you have Taoist and ...
Biological phenomena are so complex that they can be logically explained only in the light of evolution. Evolution therefore has to be brought into picture while studying any aspect of zoology, namely, anatomy, embryology, cytology or physiology. The fact that animals and plants change and do not remain static during the course of time is the backbone of evolutionary reasoning. Dobzhanskys view that nothing makes sense in biology except in the light of evolution outlines the importance of this branch of science. The word evolution simply means a change with time, and organic evolution means change in plants and animals from generation to generation, which Darwin called, "descent with modification".. Evolution is the outcome of interaction of organisms with their environment. As animals try to adapt to the changing environment, adaptive structures arise by gradual change in the existing organs, which over a period of time accumulate to form large anatomical changes that we call marvels of ...
The nano(bio)molecular technology covers both synthetic or natural systems with nanometric size or the functionality of the relevant components on the nanometer scale, which results in new and unique properties of the material. This branch of science occupies now a prosperous niche in medicine, known as nanomedicine, in particular in the field of transport and controlled release of therapeutic agents through the use of nano-engineered carriers. It is estimated that several hundred different nanocarriers are in pre-clinical and clinical development throughout the world. These nanometer-sized molecular entities have the primary function of transporting the active agent to the target site, protecting it from degradation and allowing his safe crossing through the biological barriers. To achieve these ambitious goals, however, the nanocarriers have to be carefully designed and manufactured and the thermodynamics that drives their relationship with the biological target amount is one of the ...
Wind speed forecasting plays a key role in wind-related engineering studies and is important in the management of wind farms. Current forecasting models based on different optimization algorithms can be adapted to various wind speed time series data. However, these methodologies cannot aggregate different hybrid forecasting methods and take advantage of the component models. To avoid these limitations, we propose a novel combined forecasting model called SSA-PSO-DWCM, i.e., particle swarm optimization (PSO) determined weight coefficients model. This model consisted of three main steps: one is the decomposition of the original wind speed signals to discard the noise, the second is the parameter optimization of the forecasting method, and the last is the combination of different models in a nonlinear way. The proposed combined model is examined by forecasting the wind speed (10-min intervals) of wind turbine 5 located in the Penglai region of China. The simulations reveal that the proposed combined model