TY - JOUR. T1 - Ventriculoperitoneal shunt infection due to listeria monocytogenes. AU - Dominguez, Edward A.. AU - Patil, Aron A.. AU - Johnson, William M.. PY - 1994/7. Y1 - 1994/7. UR - http://www.scopus.com/inward/record.url?scp=0028291853&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0028291853&partnerID=8YFLogxK. U2 - 10.1093/clinids/19.1.223. DO - 10.1093/clinids/19.1.223. M3 - Article. C2 - 7677812. AN - SCOPUS:0028291853. VL - 19. SP - 223. EP - 224. JO - Clinical Infectious Diseases. JF - Clinical Infectious Diseases. SN - 1058-4838. IS - 1. ER - ...

TY - JOUR. T1 - Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections. AU - Hooton, Thomas M.. AU - Stapleton, Ann E.. AU - Roberts, Pacita L.. AU - Winter, Carol. AU - Scholes, Delia. AU - Bavendam, Tamara. AU - Stamm, Walter E.. PY - 1999/12/1. Y1 - 1999/12/1. UR - http://www.scopus.com/inward/record.url?scp=0033371663&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0033371663&partnerID=8YFLogxK. U2 - 10.1086/313528. DO - 10.1086/313528. M3 - Article. C2 - 10585838. AN - SCOPUS:0033371663. VL - 29. SP - 1600. EP - 1601. JO - Clinical Infectious Diseases. JF - Clinical Infectious Diseases. SN - 1058-4838. IS - 6. ER - ...

TY - JOUR. T1 - Vancomycin telephone. AU - Drekonja, Dimitri M.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/7/15. Y1 - 2011/7/15. UR - http://www.scopus.com/inward/record.url?scp=79959742278&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79959742278&partnerID=8YFLogxK. U2 - 10.1093/cid/cir311. DO - 10.1093/cid/cir311. M3 - Letter. C2 - 21690636. AN - SCOPUS:79959742278. VL - 53. SP - 211. EP - 212. JO - Clinical Infectious Diseases. JF - Clinical Infectious Diseases. SN - 1058-4838. IS - 2. ER - ...

TY - JOUR. T1 - Safety, censoring, and intent-to-treat analysis. T2 - Dangers to generalizability. AU - Boulware, David R.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010/10/15. Y1 - 2010/10/15. UR - http://www.scopus.com/inward/record.url?scp=77957824492&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=77957824492&partnerID=8YFLogxK. U2 - 10.1086/656436. DO - 10.1086/656436. M3 - Letter. C2 - 20858076. AN - SCOPUS:77957824492. VL - 51. SP - 985. EP - 986. JO - Clinical Infectious Diseases. JF - Clinical Infectious Diseases. SN - 1058-4838. IS - 8. ER - ...

To assess the mortality and resource utilization that results from acute renal failure associated with amphotericin B therapy, 707 adult admissions in which parenteral amphotericin B therapy was given were studied at a tertiary-care hospital. Main outcome measures were mortality, length of stay, and costs; we controlled for potential confounders, including age, sex, insurance status, baseline creatinine level, length of stay before beginning amphotericin B therapy, and severity of illness. Among 707 admissions, there were 212 episodes (30%) of acute renal failure. When renal failure developed, the mortality rate was much higher: 54% versus 16% (adjusted odds of death, 6.6). When acute renal failure occurred, the mean adjusted increase in length of stay was 8.2 days, and the adjusted total cost was $29,823. Although residual confounding exists despite adjustment, the increases in resource utilization that we found are large and the associated mortality is high when acute renal failure occurs ...

Background. Because antiretrovirals are becoming increasingly available in developing countries, we reviewed the findings of studies that have documented highly active antiretroviral therapy (HAART) use in Africa to identify lessons learned. With the World Health Organization (WHO) guidelines used as a frame of reference, we assessed the feasibility of implementing such programs in Africa. Moreover, clinical and laboratory outcomes were compiled to determine the effectiveness of HAART programs.. Methods. We searched academic databases and recent conference abstracts for studies, and we included all studies that documented patients receiving HAART in Africa. In particular, we examined studies for such program features as type of regimen and frequency of monitoring, in addition to evaluations of patient outcomes.. Results. Twenty-eight articles and abstracts involving studies from 14 African countries were reviewed. Overall, 6052 patients (96.4%) were receiving HAART, mainly consisting of 2 ...

Babesia microti causes babesiosis-a zoonosis acquired chiefly in the coastal areas and islands off the northeastern coast of the United States (e.g., Nantucket Island). The sporozoan organism is endemic in rodents and is transmitted by the bite of the tick Ixodes dammini (renamed I. scapularis), the same species of tick that transmits Borrelia burgdorferi, the agent of Lyme disease. Babesia infects red blood cells, causing them to lyse, but unlike plasmodia, it has no exoerythrocytic phase. Asplenic patients and patients being treated with rituximab are affected more severely. ...

Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A. Jähn, Roger James, Roland Krause, Stanley J.F. Laulederkind, Hanns Lochmüller, Gholson J. Lyon, Soichi Ogishima, Annie Olry, Willem H. Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H. Scott, Michael Segal, Panagiotis I. Sergouniotis, Richard Sever, Cynthia L. Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W.M. Veltman, Tom Vulliamy, Jing Yu, Julie Von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O.B. Jacobsen, Tudor Groza, Damian Smedley, Christopher J. Mungall, Melissa Haendel, Peter N. Robinson ...

POSTER 8 - 3-D VISUALIZATION OF MOUSE EMBRYOS WITH OPTICAL PROJECTION TOMOGRAPHY Walls JR 1, Sled JG 1, Bruneau BG 2, Sharpe J 3, Henkelman RM 1 1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada, 2 Hospital for Sick Children, Toronto, Canada, 3 Human Genetics Unit, Medical Research Council, Edinburgh, United Kingdom The ability to visualize the 3D organization of biological tissue is essential to unravelling its complexities. A new imaging technique called Optical Projection Tomography (OPT), essentially an optical version of X-Ray computed tomography (CT), fills a gap among current imaging modalities by creating molecularly specific, cellular resolution images of specimens up to 1 cc in size. The visualization of a specific genes pattern of expression is essential to gain an understanding of its role. Mutant comparisons performed with OPT are more sensitive to spatial complexity than comparisons performed with serial sectioning techniques that might alter subtle morphology. ...

Church DM, Agarwala R, Chen H-C, Chetvernin S, Ermolaeva O, Geer R, Hlavina W, Jang W, Johnson P, Kans J, Katz K, Kitts P, Lipman D, Meric P, Ostell J, Pruitt K, Resenchuk S, Sapojnikov V, Schuler G, Sherry S, Shkeda A, Wagner L, Tatusova T, Maglott D. 136. THE MOUSE GENOME INFORMATICS DATABASE: A COMPREHENSIVE ONLINE RESOURCE FOR THE MAMMALIAN GENOMICS RESEARCH COMMUNITY ...

Most of the classes in the pre-composed phenotype ontologies are gross anatomy phenotypes - they can be defined in terms of a quality of some part of the body. For example: MP:decreased diameter of femur*; MP:hypothalamus hypoplasia; MP:large lymphoid organs; MP:muscular atrophy; MP:truncated notochord*; MP:motor neuron degeneration*; MP:axon degeneration*; HP:narrow pelvis*; TO:leaf area*; WP:shrunken intestine*; MP:situs inversus* (examples marked with an asterisk are shown in Table 4).. The first step to creating mappings for these pre-composed phenotypes is selection of the appropriate anatomical ontology. For worm and plant phenotypes, there is a single unified gross anatomy ontology covering each. For human phenotypes from HP, we use the FMA, and although the FMA does not include developing structures, this is not currently a limitation because the HP does not include many phenotypes for developing structures such as neural tube.. The MP is intended as a mammalian phenotype ontology. ...

Historically, IFOMIS originated in April 2002 utilizing the Wolfgang Paul Award of the Alexander von Humboldt Foundation to Prof. Barry Smith. Substantial funding was provided also by the Volkswagen Foundation and by the European Commission. IFOMIS comprehends an interdisciplinary research group, with members from Philosophy, Computer and Information Science, Logic, Medicine, and Medical Informatics. Inquiries regarding long- and short-term research visits are welcome. ...

Improving efficiency of disease diagnosis based on phenotype ontology is a critical yet challenging research area. Recently, Human Phenotype Ontology (HPO)-based semantic similarity has been affectively and widely used to identify causative genes and diseases. However, current phenotype similarity measurements just consider the annotations and hierarchy structure of HPO, neglecting the definition description of phenotype terms. In this paper, we propose a novel phenotype similarity measurement, termed as DisPheno, which adequately incorporates the definition of phenotype terms in addition to HPO structure and annotations to measure the similarity between phenotype terms. DisPheno also integrates phenotype term associations into phenotype-set similarity measurement using gene and disease annotations of phenotype terms. Compared with five existing state-of-the-art methods, DisPheno shows great performance in HPO-based phenotype semantic similarity measurement and improves the efficiency of disease

Unsere breite Palette Geheimratskäse diagnostischen Spielbank Esplanade und Lösungen bieten wertvolle Unterstützung für die klinische Entscheidungsfindung. The severity of the flu season, which varies from year to year, and any spread of Ebola in Las Vegas Essen United States, will be critical factors in how strained hospital resources may become. Edward T. Flu season typically begins in November and peaks in January or February. Clinical Infectious Diseases ;57(S3):S-70 and Chief, Division of Infectious Disease Diagnostics, North Shore-Long Island Jewish Health System. North Shore-Long Island Jewish Research Institute; Original Assignee: North Shore-Long Island Jewish claims description 3; Candida infections Diseases claims description 3 heat treatment Methods description 1; heteroatoms Chemical ID=​ The woman had been to South Africa, more than 3, miles (5, km) from the Dr. Bruce Hirsch, an infectious diseases specialist at North Shore University. North Shore-Long Island Jewish Research ...

Faden, R.R., Taylor, H.A., Seiler, N.K. (2003). Consent and compensation: A social compact for smallpox vaccine policy in the event of an attack. Clinical Infectious Diseases, 36(12), 1547-1551.. ...

Shulman, ST; Bisno, AL; Clegg, HW; Gerber, MA; Kaplan, EL; Lee, G; Martin, JM; Van Beneden, C (Sep 9, 2012). Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 55 (10): e86-102. doi:10.1093/cid/cis629. PMID 22965026. ...

h1,HIV Drug Appears to Prevent Infection Even in High-Risk Settings,/h1, ,p class=byline,by Hannah Guzik, California Health Report ,br /,September 2, 2015,/p, ,p,An HIV drug appears to prevent infection, even in high-risk settings, according to the results of a new study.,/p, ,p,Despite often not using condoms, none of the 657 patients taking the medication in the study had a new HIV infection during two-and-a-half years of observation by researchers at Kaiser Permanente San Francisco Medical Center. The results were ,a href=http://cid.oxfordjournals.org/content/early/2015/09/01/cid.civ778.full.pdf+html,published online,/a, Tuesday by the peer-reviewed journal Clinical Infectious Diseases.,/p, ,p,Nearly all - 99 percent - of the patients in the study were men who have sex with men.,/p, ,p,The results of the study also suggest that patients taking the drug, commercially called Truvada, may be less likely to use condoms than they were before, potentially making them more vulnerable to other ...

ORCID: https://orcid.org/0000-0002-9109-350X (2018) Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis. BMC Infectious Diseases, Vol 18, Issue 1. Thomas, J. E., Bunn, J., Kleanthous, H., Monath, T. P., Harding, M., Coward, W. A. and Weaver, L. T. (2004) Specific immunoglobulin A antibodies in maternal milk and delayed Helicobacter pylori colonization in Gambian infants. Clinical Infectious Diseases, Vol 39, Issue 8, pp. 1155-1160. Thomas, Jennifer Dolan, Hatcher, Cynthia P, Satterfield, Dara A, Theodore, M Jordan, Bach, Michelle C, Linscott, Kristin B, Zhao, Xin, Wang, Zin, Mair, Raydel, Schmink, Susanna, Arnold, Kathryn E, Stephens, David S, Harrison, Lee H, Hollick, Rosemary A, Andrade, Ana Lucia, Lamaro-Cardosa, Juliana, de Lemos, Ana Paula S, Gritzfeld, Jenna, Gordon, Stephen ...

Shlaes, D.M., Gerding, D.N., John Jr., J.F., et al. (1997) Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance Guidelines for the prevention of antimicrobial resistance in hospitals. Clinical Infectious Diseases, 25, 584-599.

Clinical Infectious Disease Specialists 2435 Fire Mesa St., Ste 120 • Las Vegas, NV 89128 702-968-2437 2610 W. Horizon Ridge, Ste. 103 • Henderson, NV 89052 702-586-0202. Dr. Rajat Sood MD, ...

Simon Collins, HIV i-Base. Experience of PrEP use outside a clinical trial in a high incidence population were presented from a retrospective analysis of people accessing care at the Kaiser Permanente Medical Centre in San Francisco, California.. This analysis described all patients at the centre who were evaluated for and started on PrEP from July 2012 (when PrEP was approved in the US) to February 2015. The results were reported by Jonathan Volk and colleagues and are available as an open access paper in the 1 September edition of Clinical Infectious Diseases. [1]. Use was low during the first year (less than 5 to 10 people starting PrEP each month), steadily increasing to approximately 40 people a month at the end of the second year and reaching 50 to 60 for the last six months. Approximately 80% of the 1045 referrals led to an evaluation with at least one clinic visit (n=908) and of these, 657 individuals started PrEP. This cohort was 99% gay men, with one heterosexual women and one ...

1.98% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased red blood cell distribution width (43/2177) 1.30% females (28/2150) 1.79% males (39/2173) ...

Bakker, O. J., Van Santvoort, H. C., Van Brunschot, S., Geskus, R. B., Besselink, M. G., Bollen, T. L., … Timmer, R. (2012). Endoscopic Transgastric vs Surgical Necrosectomy for Infected Necrotizing Pancreatitis: A Randomized Trial. JAMA, 307(10), 1053-1061. doi:10.1001/jama.2012.276. Baron, T.H., & Morgan, D.E. (1999). Acute necrotizing pancreatitis The New England journal of medicine, 340 (18), 1412-1417. Beger, H.G. (1986). Bacterial contamination of pancreatic necrosis. A prospective clinical study. Gastroenterology, 91 (2), 433-438. Bradley, E. L. (1993). A Clinically Based Classification System for Acute Pancreatitis: Summary of the International Symposium on Acute Pancreatitis. Archive Surgery, 128(5), 586590. doi:10.1001/archsurg.1993.01420170122019. Chiu, C. H., Lin, T.Y., & Wu, J. L. (1996). Acute Pancreatitis Associated with Streptococcal Toxic Shock Syndrome, Clinical Infectious Diseases, 22(4), 724-726. doi:/10.1093/clinids/22.4.724. Cusack, T. P., Ashley, E. A., Ling, C. L., ...

In addition to the history and physical examination, clinical diagnosis of CNS infections requires a spinal fluid analysis combined with neuroimaging using either magnetic resonance imaging (MRI) or computed tomography (CT) scan. Microbiologic diagnosis of bacterial infections frequently is made using Gram stain and culture of spinal fluid and blood. Polymerase chain reaction (PCR) assays and serologic tests are also useful. Antimicrobial therapy requires that the antibiotics be bactericidal and that they penetrate the blood-brain barrier. Some CNS infections, such as a brain abscess, often require surgical drainage. ...

aDepartment of Infectious Disease Epidemiology, TB Modelling Group, TB Centre, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine bDepartment of Infection and Population Health, Centre for Infectious Disease Epidemiology, University College London, London, UK cDepartment of Medicine, Institute of Infectious Disease and Molecular Medicine, University of Cape Town dDivision of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa eTuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA fCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa gDepartment of Medicine, Imperial College London hThe Francis Crick Institute Mill Hill Laboratory, London, UK iInstitute of Infectious Diseases and ...

Adachi K, Xu J, Ank B, Watts HD, Mofenson LM, Pilotto JH, Joao E, Santos B, Fonseca R, Kreitchmann R et al.. 2017. Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Abstract ...

Adachi K, Xu J, Ank B, Watts HD, Mofenson LM, Pilotto JH, Joao E, Santos B, Fonseca R, Kreitchmann R et al.. 2017. Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Abstract ...

by Physicians Weekly , Dec 13, 2012. Recent estimates suggest that the direct annual costs of sinusitis are approximately $5.8 billion in the United States, and nearly one in seven Americans is diagnosed with a sinus infection every year. Rhinosinusitis is one of the most common reasons patients seek medical help. It ranks among the top five reasons for antibiotic prescriptions for adults. However, 90% to 98% of patients presenting with symptoms of sinusitis have viral causes and will not benefit from antibiotics. The overuse of antibiotics among this population has contributed largely to the emergence of antimicrobial resistance. The Need for Guidance Clinicians need clear guidance on how to treat patients with rhinosinusitis and on how to differentiate viral from bacterial infections, says Thomas M. File, Jr., MD. In the April 15, 2012 issue of Clinical Infectious Diseases, Dr. File coauthored guidelines from the Infectious Disease Society of America (IDSA) on acute bacterial rhinosinusitis ...

The devastation of the last two years of the Ebola crisis in West Africa was made all the more daunting by a predictable aspect of its toll. The health workers who represented the best hope of controlling the outbreak were also at the greatest risk of illness and death. By the dwindling days of the epidemic across Guinea, Sierra Leone and Liberia, at least 500 of the more than 11,300 people who had lost their lives to virus were health workers.. That illness is an occupational hazard on the front lines of health care is not new, a Clinical Infectious Diseases supplement on tuberculosis control in health settings notes, but it continues to be neglected at every level. And, as authors of one article note, while the death toll of the 2014-2015 Ebola outbreak is replicated by tuberculosis every three days worldwide, health workers in high burden and low-resource settings face risks at least three times those of the general population. They include doctors, nurses, counselors, administrative staff, ...

After an airline passenger vomited on a plane, almost half of flight attendants who subsequently worked on the same plane developed gastrointestinal symptoms, and two who submitted stool samples were infected with norovirus, according to a study in Clinical Infectious Diseases. Researchers analyzed data from nine flights over 6 days of a Boeing 777-200 after a passenger vomited on the plane and flight attendants subsequently began getting sick. Eight of the flights were international legs that lasted longer than 10 hours. Of the 77 attendants who worked those flights, 63 provided information, and, of those, 27 (43%) met the case definition for gastroenteritis. The attack rate rose to 79% for crew supervisors and declined over time. Two patients who worked different flights provided stool samples, both of which tested positive for norovirus. The authors write, Findings from our investigation suggest that flight attendants were infected through their work on the airplane, with transmission ...

Source: Donald A. Henderson, etal, Smallpox Vaccination in 2003: Key Information for Clinicians, Clinical Infectious Diseases, Vol. 36: 883-902, (2003).. Now, four months after the campaign has commenced, impediments to participation have brought it to a virtual standstill. The program has proven to be less popular, medically riskier and more expensive than anticipated. Many health care professionals maintain the benefits of the program do not justify the risks and recommend it be delayed until there is clear evidence a smallpox attack is imminent.[3] Furthermore, more than a dozen states have suspended vaccination until more is learned about its recent link to myocarditis and heart attacks.[4]. What measures can be taken to bolster this policys waning success, and should they be taken? Initiating a large-scale vaccination effort against a disease that is no longer a natural threat presents many challenges for the medical community. A look at the history of smallpox in the U.S. and the ...

The Holy Grail of neurosyphilis is a specific and sensitive diagnostic test that can be done on cerebrospinal fluid (CSF) to diagnosis this disease. The goal of the study by Vanhaecke et al, reported in this issue of Clinical Infectious Diseases, was to study the utility of polymerase chain reaction (PCR) for the tpp47 gene of Treponema pallidum in 40 patients with well-documented neurosyphilis [1]. But, as the authors themselves state, Neurosyphilis has multiple clinical presentations, and there is no consensus concerning its definition. For reasons that I will explore below, confusion over the diagnosis of neurosyphilis leaves this reader uncertain as to which patients in Vanhaecke et als series of 40 cases actually had neurosyphilis. In this context, the addition of PCR does not look to be very helpful. During the incubation period leading up to the appearance of a chancre, and while the chancre is present, T. pallidum disseminates widely throughout the body. Organisms may be found in ...

Patients are not at increased risk of Guillain-Barre syndrome in the six-week period after vaccination with any vaccine, including influenza, according to a Kaiser Permanente study published in Clinical Infectious Diseases.. The retrospective study by researchers at the Kaiser Permanente Vaccine Study Center spanned 13 years and was controlled for seasonality.. If there is a risk of Guillain-Barré syndrome following any vaccine, including influenza vaccines, it is extremely low, said Roger Baxter, MD, co-director of the Kaiser Permanente Vaccine Study Center.. During the 13-year period (1994-2006), 415 confirmed cases of Guillain-Barré syndrome were observed. Within this group, the researchers found only 25 patients had received any vaccine in the six weeks prior to the onset of the disease. The study also found that 277 patients had a respiratory or gastrointestinal illness in the 90 days preceding the onset.. Guillain-Barré syndrome is an acute disease thought to be an autoimmune disorder ...

For a number of years it was widely felt that the first of the new so-called 5th Generation, or anti-MRSA cephalosporins would be ceftobiprole. This drug, a joint venture by the Swiss company Basilea and Johnson & Johnson had come under some fire from the FDA (see my blog entry from Dec 31, 2009) and now looks like it has pretty much been abandoned, at least here in the US. Even in Canada, where it had been approved for complicated skin and skin structure infections (cSSSI), as of April 2010 sales have been discontinued.. While all of the hoopla surrounded ceftobiprole, another drug was pretty quietly making its way through the clinical trial process; ceftaroline. Ceftaroline is being developed by Cerexa Inc., a wholly owned subsidiary of New Yorks Forest Pharmaceuticals under license from Takeda in Japan. This month has proven to be an important one for this antibiotic. In the September 15 issue of Clinical Infectious Diseases the results of their cSSSI trial, named the CANVAS study have ...

Originally published by CIDRAP News May 31. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) appears to be spreading further into the community and healthcare settings in Denmark, researchers reported yesterday in Clinical Infectious Diseases.. In the study, researchers evaluated data on all Danish patients who were registered as having had an episode of MRSA bloodstream infection (BSI) or skin and soft tissue infection (SSTI) from 2010 through 2015. Using molecular sequencing tests, they set out to determine how many were caused by LA-MRSA clonal complex 398 (CC398), which has been causing an increasing number of human infections in Denmark and other European countries with industrial pig production. While SSTIs caused by LA-MRSA CC398 have been studied and are mainly associated with livestock workers, less is known about the strains impact on BSIs.. The researchers also wanted to compare LA-MRSA CC398 BSI cases to SSTI cases caused by the strain and to BSI cases ...

PubMedID: 25995207 | Clinical Features of Patients With Ebola Virus Disease in Sierra Leone. | Clinical Infectious Diseases | 8/15/2015

Zanger, P., Nurjadi, D., Gaile, M., Gabrysch, S. and Kremsner, P.G. (2012) Hormonal Contraceptive Use and Persistent Staphylococcus aureus Nasal Carriage. Clinical Infectious Diseases, 55, 1625-1632.

The Src family kinase (SFK) member SRC is a major target in drug development because it is activated in many human cancers, yet deleterious SRC germline mutations have not been reported. We used genome sequencing and Human Phenotype Ontology patient coding to identify a gain-of-function mutation in SRC causing thrombocytopenia, myelofibrosis, bleeding, and bone pathologies in nine cases. Modeling of the E527K substitution predicts loss of SRCs self-inhibitory capacity, which we confirmed with in vitro studies showing increased SRC kinase activity and enhanced Tyr419 phosphorylation in COS-7 cells overexpressing E527K SRC. The active form of SRC predominates in patients platelets, resulting in enhanced overall tyrosine phosphorylation. Patients with myelofibrosis have hypercellular bone marrow with trilineage dysplasia, and their stem cells grown in vitro form more myeloid and megakaryocyte (MK) colonies than control cells. These MKs generate platelets that are dysmorphic, low in number, highly ...

These examples vividly illustrate how technology has brought beneficial change to entertainment, retailing and education, so the question is why cant we use technology to change the body politic?. As the founder of Social Revolution, I am trying to do just that. Social Revolution aims to harness innovative ideas through crowdsourcing, and distill them into a Business Plan for U.S.A. to help propel the country forward.. Were going to crowdsource ideas in five key areas - education, healthcare, business, finance and government. All these sectors are clearly ripe for a major disruption.. To manage the idea stream, were relying on an innovative crowdsourcing platform from Pleasanton, Calif.-based Spigit. If youre a company or individual that wants real change, and have a cogent idea about how to implement it, we want to hear from you. If youre using technology to make things better, we need to hear from you.. At Social Revolution, we believe that applying the new technologies offered by ...

Windows SharePoint Services manages what a user account can do with permissions. There is a large list of set permissions that are available at the web application level. These permissions, when applied to a user account, govern what it can do. Permissions are generally grouped together in what are called permission levels, to be applied to users based on the type of role they will play, or tasks they will perform in Windows SharePoint Services. There are a few default permission levels, such as full control (which usually is applied to administrators who require all permissions to be enabled), or contribute (which is usually applied to users who will be viewing content, adding content, editing content, etc.). Individual permissions cant be applied to users directly, but permission levels can. For the convenience of administrators, in addition to permission levels putting together useful permissions into role based combinations, Windows SharePoint Services uses another convention; the ...

TY - JOUR. T1 - Beyond knockouts: cre resources for conditional mutagenesis. AU - Murray, Stephen A. AU - Eppig, Janan. AU - Smedley, Damian. AU - Simpson, Elizabeth M. AU - Rosenthal, Nadia Alicia. PY - 2012. Y1 - 2012. N2 - With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best ...

Bio-ontologies provide terminologies for the scientific community to describe biomedical entities in a standardized manner. There are multiple initiatives that are developing biomedical terminologies for the purpose of providing better annotation, data integration and mining capabilities. Terminology resources devised for multiple purposes inherently diverge in content and structure. A major issue of biomedical data integration is the development of overlapping terms, ambiguous classifications and inconsistencies represented across databases and publications. The disease ontology (DO) was developed over the past decade to address data integration, standardization and annotation issues for human disease data. We have established a DO cancer project to be a focused view of cancer terms within the DO. The DO cancer project mapped 386 cancer terms from the Catalogue of Somatic Mutations in Cancer (COSMIC), The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium, Therapeutically Applicable

Medical ontologies are expected to contribute to the effective use of medical information resources that store considerable amount of data. In this study, we focused on disease ontology because the complicated mechanisms of diseases are related to concepts across various medical domains. The authors developed a River Flow Model (RFM) of diseases, which captures diseases as the causal chains of abnormal states. It represents causes of diseases, disease progression, and downstream consequences of diseases, which is compliant with the intuition of medical experts. In this paper, we discuss a fact repository for causal chains of disease based on the disease ontology. It could be a valuable knowledge base for advanced medical information systems. We developed the fact repository for causal chains of diseases based on our disease ontology and abnormality ontology. This section summarizes these two ontologies. It is developed as linked data so that information scientists can access it using SPARQL queries

A free online platform is being developed that uses a crowdsourcing approach to make public gene expression data more accessible to biomedical researchers.

The trend of open collaboration has led to innovation across multiple industries. For decades, big pharma has been known as conservative and slow to change. Today however, there is a growing movement toward open access and crowdsourcing scientific information to accelerate research and development.

The trend of open collaboration has led to innovation across multiple industries. For decades, big pharma has been known as conservative and slow to change. Today however, there is a growing movement toward open access and crowdsourcing scientific information to accelerate research and development.

Are there additional ways that biochemists could benefit from crowdsourcing? What if there was a website for biochemists to compare notes in their roles as customers regarding their experiences with journals and with vendors. For example, 2011 has been a good year for my research group in terms of paper publishing. Four original research articles made it through the evaluation process, and two more are about to be submitted. Each of these will appear in a different journal, and my experience with each journal was distinct. The manuscript-submission websites varied in terms of ease of use, clarity and time required to complete the submission; the time for review varied significantly; the quality of the reviews differed; and each paper was subject to a different level of academic editor oversight. Scientists gossip about such differences, but what if there were a Biochemadvisor.com website with reviews of our experiences as customers of different journals? Whenever I am planning a trip to a new ...

Though DARPA very well may reap this reward, the agency is getting something else which is perhaps even more valuable - its collecting the hundreds of design ideas being submitted via contest entries and comments. Unlike typical crowdsourcing contests which ask participants to submit and/or vote on entries, the DARPA contest allows contestants to revise and resubmit their entries as often as they like, encouraging frequent comments from fellow participants at several stages along the way. The DARPA contest does have a voting component, though this has little to do with selecting a winner; that will be done by DARPA and Local Motors around March 15th. Instead, the votes, like the ubiquitous comments, are just part of the feedback generated by the contestants. In essence, the contest has produced a storehouse of collective intelligence and know-how that DARPA can return to for future projects whenever it likes ...

Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are ...

Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are ...

Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants. However, the phenome or spectrum of all phenotypes associated with genetic variants in extracellular matrix genes is unknown. Here, we analyzed over two million recorded genotype-to-phenotype relationships across multiple species to define their extracellular matrix phenomes. By using the previously defined matrisomes of humans, mice, zebrafish, Drosophila, and C. elegans, we found that the extracellular matrix phenome comprises of 3-10% of the entire phenome. Collagens (COL1A1, COL2A1) and fibrillin (FBN1) are each associated with ,150 distinct phenotypes in humans, whereas collagen COL4A1, Wnt- and sonic hedgehog (shh) signaling are predominantly associated in other species. We determined the phenotypic fingerprints of matrisome genes and found that MSTN, CTSD, LAMB2, HSPG2, and ...

Description: Ontology alignment, the task of identifying mappings between ontologies, is a key task for knowledge sharing between applications that use different ontologies. Manual alignment is time-consuming and difficult when dealing with large ontologies, which are common in biomedical domain, while automatic alignment shows low coverage. We present a tool with user-friendly GUI for semi-automatic ontology alignment, called NViz. It helps human experts focus on pairs of ontology clusters that are likely to have missing mappings. NViz utilizes a state of-the-art system of ontology alignment, called BOAT, and a hierarchical clustering method. Institution: Nanyang Technological University Contacts: Watson W.K. Chua, Jung-jae Kim, Bui Duc Hieu Home Page: http://nlp.sce.ntu.edu.sg/wiki/projects/nviz/NViz.html ...

The following is a list of libraries from ProgrammableWebs Library Directory that matched your search term. Although there many different interpretations of the word library among software developers, ProgrammableWeb adheres to a specific definition so as to clearly distinguish libraries from SDKs and frameworks in a way that will facilitate clean search results. In ProgrammableWebs parlance, the term library is strictly used to describe a platform-specific software tool that, when installed, results in the provisioning a specific API. Conversely, SDKs are exclusively for consuming APIs and Frameworks are agnostic to specific APIs. If you think a library, SDK, API, or other asset is missing from our directory, be sure to check our guidelines for making contributions to ProgrammableWeb ...

The administrator can assign their permission. Roles Permissions- Go to System Settings > Roles Permissions here we can create different Roles for staff users and then assign different user permission to this Role. To add new role enter Role Name then click on Save button all existing roles can be see from right side of this page. By default in Iskool School you will get 6 user roles SuperAdmin, Admin, Teacher, Accountant, Librarian, Receptionist. You can edit name or permission of these roles except SuperAdmin. To assign permission click on Assign Permission button from Action column. At this page you can see Module wise different Features and their different Permissions. Carefully assign different permissions on roles. After assigning permission, check where it is effecting in system. There are 4 types of permissions present here View, Add, Edit and Delete. Here note that if you are assigning Add/Edit or Delete permission then View permission should be given obviously if you have not given ...

There are currently no human or mouse genes associated with this disease in the MGI database. Synonyms: Andermann syndrome; Charlevoix disease; corpus callosum agenesis-neuronopathy syndrome

There are currently no human or mouse genes associated with this disease in the MGI database. Synonyms: Band-shaped keratopathy