The tick-tock of your biological clock may have just gotten a little louder.. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important. "This new finding may help to explain why the clock is so far-reaching in its effects on the organism," said Jonathan Arnold, a professor in the UGA department of genetics and director of the research project. "We found that some 25 percent of the genes in our model organism appear to be under clock control. I wasnt suspecting anything remotely like that.". The new research, just published in the Public Library of Science One, also shows how Arnolds team used a new methodology called Computing Life to yield these new discoveries about biological clocks. And this tool of systems biology was the key to showing ...
December 31, 2008. Science Daily/Hebrew University of Jerusalem. Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyones 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.. The biological clock regulates the expression and/or activity of enzymes and hormones involved in metabolism, and disturbance of the clock can lead to such phenomena as hormone imbalance, obesity, psychological and sleep disorders and cancer.. While light is the strongest factor affecting the circadian clock, Dr. Oren Froy and his colleagues of the Institute of Biochemistry, Food Science and Nutrition at the Hebrew Universitys Robert H. Smith Faculty of Agriculture, Food and Environment in Rehovot, have demonstrated in their experiments with laboratory mice that there is a cause-and-effect relation between diet and biological clock imbalance.. To examine this thesis, Froy and his ...
Ivanhoe Newswire) -- If you regularly experience the pangs of jet lag or a crazy work schedule, then you may not be the biggest fan of your bodys biological clock. Fortunately, a new molecular compound dubbed "longdaysin" has recently shown the ability to trick it into slowing down or speeding up to potentially meet different needs.. Researchers at the University of California San Diego and three other research centers found longdaysin by conducting an automated screening of over 120,000 compounds using a robot designed to test the effects of the compounds on a series of human bone cancer cells. These cells were genetically altered with two genes: an attached clock gene, which stimulates the cells circadian rhythm, and a luciferase gene, which lights up when the biological clock was triggered (also seen in the glow of fireflies). The robot was programmed to isolate the molecules that showed the greatest effects on the cells biological clocks. After discovering longdaysin to be the most ...
NYU (US) - Biologists have uncovered one way that biological clocks control neuronal activity-a discovery that sheds new light on sleep-wake cycles. "The findings answer a significant question-how biological clocks drive the activity of clock neurons, which, in turn, regulate behavioral rhythms," explains Justin Blau, an associate professor in New York Universitys department of biology and the studys senior author.. Their findings, which also offer potential new directions for research into ways to address sleep disorders and jetlag, appear in the Journal of Biological Rhythms.. [sources]. Scientists have known that our biological clocks control neuronal activity. But not previously understood is how this process occurs-that is, how does information from biological clocks drive rhythms in the electrical activity of pacemaker neurons that, in turn, drives daily rhythms?. To understand this mechanism, the researchers examined the biological, or circadian, clocks of Drosophila fruit flies, which ...
2010. 26cm. Pp.280. Hardbound.Biological Clock in Fish reviews the state of knowledge in sufficient detail and presents the latest contributions to the field, showing fish provide a unique model of the circadian biological clock. 1578086752
Cellular and Molecular Bases of Biological Clocks: Models and Mechanisms for Circadian Timekeeping by Leland N. Jr. Edmunds and a great selection of similar Used, New and Collectible Books available now at AbeBooks.com.
Published in the journal BMC Biology, these results show for the first time that directly targeting the biological clock in a cancerous tumour has an impact on its development.. Most of the cells in the human body have an internal clock that sets a rhythm for the activities of our organs according to the time of the day. Cancer cells, however, often have a non-functioning or malfunctioning clock.. "There were indications suggesting that the malfunctioning clock contributed to rapid tumour growth, but this had never been demonstrated. Thanks to the use of a chemical or a thermic treatment, we succeeded in repairing these cells clock and restoring it to its normal functioning. In these conditions, tumour growth drops nearly in half," explains Cermakian, who is also Director of the Laboratory of Molecular Chronobiology at the Douglas Mental Health University Institute, one of the research centres of the CIUSSS de lOuest-de-lÎle-de-Montréal.. Although this preclinical demonstration was done ...
NADH oxidases at the external surface of plant and animal cells (ECTO-NOX proteins) exhibit stable and recurring patterns of oscillations with potentially clock-related, entrainable, and temperature-compensated period lengths of 24 min. To determine if ECTO-NOX proteins might represent the ultradian time keepers (pacemakers) of the biological clock, COS cells were transfected with cDNAs encoding tNOX proteins having a period length of 22 min or with C575A or C558A cysteine to alanine replacements having period lengths of 36 or 42 min. Here we demonstrate that such transfectants exhibited 22, 36, or 40 to 42 h circadian patterns in the activity of glyceraldehyde-3-phosphate dehydrogenase, a common clock-regulated protein, in addition to the endogenous 24 h circadian period length. The fact that the expression of a single oscillatory ECTO-NOX protein determines the period length of a circadian biochemical marker (60 X the ECTO-NOX period length) provides compelling evidence that ECTO-NOX proteins ...
A new study of molecular interactions central to the functioning of biological clocks explains how certain mutations can shorten clock timing, making some people extreme morning larks because their internal clocks operate on a 20-hour cycle instead of being synchronized with the 24-hour cycle of day and night.
The day and night cycle influences the body function in health and disease through the modulation of the biological clock in via the suprachiasmatic nucleus (SCN) which i..
The influence of noise is unavoidable in all living systems. Its impact on a model of a biological clock, normally running in regular oscillating modes, is examined. It is shown that in a specific system in which endogenous rhythmicity is produced by a beat oscillator acting on a feedback coupled metabolic pool system, noise can act coherently to produce unexpected dynamic behaviour, running from regular over pseudo-regular to irregular time-structures. If the biological system consists of a set of identical weakly coupled cells, stochasticity may lead to phase decoupling producing irregular spatio-temporal patterns. Synchronization via phase resetting can be achieved by external short-time temperature pulses. Explicit results are obtained for the well-studied circadian photosynthesis oscillations in plants performing crassulacean acid metabolism. Because of the generic structure of the underlying nonlinear dynamics they can, however, be regarded as a general property of the influence of noise ...
Alarm Clock Gene KDM5A Explains Wake-up Function of Biological Clock. Ever wondered why you wake up in the morning-even when the alarm clock isnt making jarring noises? Wonder no more.
Women in their 30s and early 40s who want to know whether their biological clocks are running out should skip fertility testing, a new study suggests.
Tricking algaes biological clock to remain in its daytime setting can dramatically boost the amount of valuable compounds these simple marine plants can produce when grown in constant light.
Washington, Aug 16 (ANI): Eyes use light to regulate the biological clock through a mechanism that is different from the ability to see, according to researchers at the University of Virginia. The finding
Researchers from the Vanderbilt University say that constant exposure to artificial light may interfere with the normal development of premature babies biological clocks.
Today I am grateful to science - it is som amazing, discovering and verifying the most amazing things! I was listening to the lecture of this Soviet scientist, Simon Shnoll, and he was telling about biological clocks that run in every living organism, and how they are aligned with the movements of earth, moon, and the…
Does the biological clock in cancer cells influence tumour growth? Yes, according to a study conducted by Nicolas Cermakian, a professor in McGill Universitys Department of Psychiatry.
Jennifer L. Fleissner; The Biological Clock: Edith Wharton, Naturalism, and the Temporality of Womanhood. American Literature 1 September 2006; 78 (3): 519-548. doi: https://doi.org/10.1215/00029831-2006-024. Download citation file:. ...
The homodimeric, growth-related and time-keeping constitutive hydroquinone oxidase ENOX1 of the eukaryotic cell surface capable of oxidizing extracellular NAD(P)H and intracellular hydroquinones...
In modern societies, the risk of developing metabolic disorders such as obesity or type-2 diabetes is associated with the prevalence of psychosocial stress. Therefore, an improved understanding of adaptive stress responses and their underlying molecular mechanisms is of high clinical interest. In response to an acute stressor, animals activate the sympathetic nervous system and the hypothalamus pituitary adrenal (HPA) axis releasing catecholamines and glucocorticoids (GCs) into the circulation. Recent data suggest that stress responses are also regulated by the endogenous circadian clock adapting physiology and behavior to the environmental changes brought about by the Earth s rotation around its axis. Thus, the timing of stress may critically affect adaptive responses to and the pathological effects of repetitive stressor exposure. We have studied the role of different tissue clocks on the regulation of HPA axis activity in mice. We further characterized the impact of predictable social defeat ...
Our bodies run on an in-built 24-hour clock embedded in a part of the brain called the suprachiasmatic nucleus (SCN). Its 20,000 nerve cells sit in the middle of the brain above the back of the eyes and on top of a structure called the hypothalamus. These are the bodys master timekeepers, setting the rhythm…
The general behavior of coupled neural oscillators is very difficult to analyze, however limiting cases can be treated ([22]). We will describe one method, the method of averaging, that has been used successfully to study the dynamics of two or more neural oscillators that are weakly coupled (e.g., Hansel [16] and Ermentrout and Kopell [9]). In this limit the coupling is sufficiently weak that each oscillators trajectory remains close to its intrinsic limit cycle. The primary effect of the coupling is to perturb the relative phase between the oscillators much as we described above. However, since the perturbation per cycle is small (with weak coupling) the net effect occurs only over many cycles and the per cycle effect is seen as averaged. For illustration, we summarize the use of averaging to describe the phase-locking properties of two identical Morris-Lecar oscillators when coupled with identical mutually excitatory synapses. Detailed derivations of the equations can be found in the above ...
γ oscillations are observed in the local field potential (LFP), which emerges as a result of spatially organized, summed current flow largely due to synaptic activity within a neural network (Mitzdorf, 1985; Barth et al., 1989; Einevoll et al., 2013). γ is the result of rhythmic synaptic output from cohorts of neurons with precise temporal relationships. However, there are varied mechanisms by which these temporal patterns occur within local neural circuits.. In the hippocampus, extensive exploration of computational and experimental models has identified multiple network mechanisms by which γ oscillations can be generated. Experimental work using pharmacological manipulations of the in vitro hippocampal slice preparation found that the 40 Hz-range field potential oscillations evoked under different circumstances exhibited different reliance on synaptic excitation and inhibition. γ oscillations induced by activating mGluR (Whittington et al., 1995) or kainate (Fisahn et al., 2004) receptors ...
Hendricks, J. C., Lu, S. M., Kume, K., Yin, J. C. P., Yang, Z. H., Sehgal, A. (2003) Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. Journal of Biological Rhythms, 18 (1). pp. 12-25. ISSN 0748-7304 Hengartner, M. O. (1997) Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Experimental Gerontology, 32 (4-5). pp. 363-74. ISSN 0531-5565 (Print) ...
Using the clock, researchers can gauge the age of diverse human organs and tissues. Unexpectedly, they found some parts of the anatomy, like womens breast ...
Numerous processes in our body fluctuate in a regular pattern during the day. These circadian (or daily) variations can be driven by local oscillators present within our cells or by systemic signals controlled by the master ...
division and reproduction of all cells from the single-celled amoeba to cells in the human body. The complexity and coordination of this cycle is staggering. The cell cycle is divided into four primary phases: G1, S, G2, and M.. G1, or the Gap 1 phase, is the time in which cells carry out all of the normal processes of the cell. Some cells remain in this phase for very long periods of time. But, when appropriate stimuli are encountered by a cell, a round of cell division is triggered. This point of no return is known as the restriction point. Once a cell passes this point, it must complete the entire cell cycle and return once more to G1. After a cell reproduces, it must prepare for the next phase of the cell cycle: S-phase or DNA synthesis phase. This preparation requires activating countless genes and making many new proteins that are used only during this one phase of the cell cycle. Once every component is ready, S-phase may begin.. During the DNA synthesis phase, the cell must make an exact ...
division and reproduction of all cells from the single-celled amoeba to cells in the human body. The complexity and coordination of this cycle is staggering. The cell cycle is divided into four primary phases: G1, S, G2, and M.. G1, or the Gap 1 phase, is the time in which cells carry out all of the normal processes of the cell. Some cells remain in this phase for very long periods of time. But, when appropriate stimuli are encountered by a cell, a round of cell division is triggered. This point of no return is known as the restriction point. Once a cell passes this point, it must complete the entire cell cycle and return once more to G1. After a cell reproduces, it must prepare for the next phase of the cell cycle: S-phase or DNA synthesis phase. This preparation requires activating countless genes and making many new proteins that are used only during this one phase of the cell cycle. Once every component is ready, S-phase may begin.. During the DNA synthesis phase, the cell must make an exact ...
Prior to dying the cell creates an "offspring" which carries on the same cellular characteristics as the mother cell. Because of the cellular damage done by cancer cells, the biological clock is altered and cancer cells do not die but proliferate. So not only does the mother cancer cell not die, but the offspring inherit the same characteristics as the mother which includes a broken biological clock.. As a result of this cancer cell population explosion, tumors are formed.. Haelan repairs the cellular damage and as a by product of this repair restores the normal programmed cell death (apoptosis) and cells resume their normal biologically determined cell death cycle. Since all cells resume their death cycle, cancer cells cease to grow and consequently die off.. 4. Increases the cyto-toxic effect of the NK Killer cells - Natural Killer cells (or NK cells) constitute a major component of the innate immune system. They play a major role in the rejection of tumors and cells infected by viruses. The ...
The acceleration in genome sequencing capacity is just incredible. In May 2010, I posted on the sequencing of the complete genomes of two parents and two of their kids. Now in August of 2012 we have the results on the complete genomes of 78 parent children trios, along with 1,859 complete sequences from the same…
They dont really supply proper data for survivorship at 1 year, while at 2 years, a close analysis shows 13% and 9% increases in mean and max LS (vs. GFP), but ALL of these animals are well within the historical norm for C57Bl/6 LS. Again - husbandry is a huge, huge issue in these types of studies - if I can get to the same or greater max or mean LS through proper husbandry, then your entire study is invalidated, because whatever treatment you are giving might merely be alleviating bad husbandry, and not a true life extension (example, if the diet you give the animals, lacks in f.ex. a vital vitamin, and you supply that vitamin and now extend the life span of the supplemented animals vs the improperly fed ones, what kind of life extension is this - it certainly is not compared to animals properly fed... i.e. your vitamin supplement would fail to extend the lifespan of properly fed animals). This is why it is critical to show max or mean LS extension against lifespan records of a given line ...
A new method for egg freezing called vitrification-a technology that its architects say will revolutionize the world of assisted reproduction -- is making the process of in vitro fertilization (IVF) less costly and more efficient than ever before.
Japanese researchers have developed a compound that can speed up the flowering of plants, a finding that could be used to allow agriculture even in colder
For this study, AMH levels were measured in 144 healthy, fertile women and the data were used to determine an estimate of mean AMH as a function of age. This information was then used to estimate the distribution of the age of menopause in a sample of 3,384 women between the ages of 50 and 70. Researchers were then able to develop a model based on AMH level and age that could predict age at menopause for individual women ...
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MangaHelpers is a place where you can find translations and scanlations for Shonen Manga, Shoujo Manga, Jyousei Manga as well as downloads for all your favorite manga series. MangaHelpers also is a community resource that helps translators and scanlators get their work known to a wider audience and thus increasing the popularity of lesser known Manga.
Modern reproductive technologies can give older women the same chances of having a baby as younger women, researchers reported Wednesday. The new study
From a young age Ive preferred babies to animals. Babies laugh at things adults find unamusing. They coo freely as if cantillating inner satisfaction. They are squishy and snuggly and impressed by my singing voice.
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When Sarah Gardner was 34, she started getting really worried about whether she'd ever have kids. "I bought this kit online that said that they
Sustained molecular oscillations are ubiquitous in biology. The obtained oscillatory patterns provide vital functions as timekeepers, pacemakers and spacemarkers. Control-theory type models have been introduced to explain how specific oscillatory behaviors stem from protein interaction feedbacks, whereas the energy dissipation through the oscillating processes and its role in the regulatory function remain elusive. Here we developed a general framework to assess oscillators regulation performance at different dissipation levels. Using Escherichia coli MinCDE oscillator as model system, we showed that, unlike stationary regulators monotonic performance-to-cost relation, excess dissipation at certain steps in the oscillating process damages the oscillators regulatory performance. We further discovered that ATP hydrolysis energy has to be strategically assigned to the MinE-aided MinD release and the MinD immobilization steps for optimal performance, and higher energy budget improves the ...
Everyone is equipped with a biological clock, a region in the brain of the size of a corn kernel, which dictates our sleep-wake cycles. A research conducted by Kent State professor David Glass has shown that this clock can be re-set, reported science portal EurekAlert ...
How does the body know how old it is? Our metabolisms change as we get older, even though our DNA doesnt change. Different genes are activated at different times of life, and the timing of gene expression is what controls growth, development, sexual maturity, and perhaps aging as well. The body keeps accurate track of how old it is, though there has been no scientific agreement about where the clocks are, or how they work. Recently, some biologists have suggested that one such biological clock might reside in the epigenetic state of the DNA. If this is true, epigenetics will become an attractive, though challenging, target for anti-aging research. If we knew where the body kept its "clock", then perhaps we could target the clock itself with biochemical interventions. We would not just be able to slow the progress of aging, but reset the clock to an earlier age.. DNA is decorated with methyl groups, small molecular add-ons that act like "Do Not Disturb" signs for the underlying gene. A gene that ...
The circadian system, better known as our biological clock, is responsible for coordinating all the processes that take place in our organism.
Route to chaos (or periodicity) in dynamical systems is one of fundamental problems. Here, dynamical behaviors of coupled chaotic Rössler oscillators on complex networks are investigated and two different types of periodic windows with the variation of coupling strength are found. Under a moderate coupling, the periodic window is intermittent, and the attractors within the window extremely sensitively depend on the initial conditions, coupling parameter, and topology of the network. Therefore, after adding or removing one edge of network, the periodic attractor can be destroyed and substituted by a chaotic one, or vice versa. In contrast, under an extremely weak coupling, another type of periodic window appears, which insensitively depends on the initial conditions, coupling parameter, and network. It is sustained and unchanged for different types of network structure. It is also found that the phase differences of the oscillators are almost discrete and randomly distributed except that ...
They are the bodys natural steroid hormones that regulate blood sugar levels-their job is to make sure peoples blood sugar levels are lowered while they sleep and then raised when they wake; this allows people to maximize the efficiency their energy use. Glucocortids also interact with anti-inflammatory drugs and this has exposed the missing-link between cryptochromes and Glucocortids. Together, they regulate the blood sugar and the biological rhythms or what is often called the biological clock.. While scientists and doctors plan to harness this information for pharmaceutical purposes, it can also be used to help people understand their bodys natural rhythms. This way, people can be more conscious of both what they eat and how their body is using what they eat based on their sleep and rest patterns. Think about it. When are people most active during the day? When are they least active? It is important for people to take the time to get to know their activity levels and then find a way to eat ...
In this paper, under certain parametric conditions we are concerned with the first integrals of the Duffing-van der Pol-type oscillator system, which include the van der Pol oscillator and the damped Duffing oscillator etc as particular cases. After applying the method of differentiable dynamics to analyze the bifurcation set and bifurcations of equilibrium points, we use the Lie symmetry reduction method to find two nontrivial infinitesimal generators and use them to construct canonical variables. Through the inverse transformations we obtain the first integrals of the original oscillator system under the given parametric conditions, and some particular cases such as the damped Duffing equation and the van der Pol oscillator system are included accordingly.
Hello all - I hope you dont mind me joining your forum. I go by JMC, and will give you a little background before I launch into my questions. My DH and I are both 38yo and have been married for almost 3 years. We have a DD (20 months) conceived naturally 2 months after we got married. For our second, we tried for about 6-7 months when we were told to stop using KY jelly (we are freakin idiots). After we stopped, we were PG again in 2 months. We were so excited esp. since weve got biological clock issues. That one miscarried and we were devastated. We couldnt believe it. We had zero issues with our first. We went in for an IUI last month to speed things along and were SHOCKED to be told DH had very few good sperm. The reason this shocked us was because we got PG twice in very little time. It doesnt seem right that this would be possible if there was a sperm problem (maybe once, but not twice, and certainly not in 2 short cycles each time). But we redid the sperm test and it didnt look any ...
Shes not alone: Caroline Levines biological clock is ticking loudly. She is 57 years old and has no grandchildren. -- from The Wall Street Journal