CONTENTSElementary Biology of Military SignificanceGeneral Properties of Biological Warfare AgentsPossible Antipersonnel Biological Warfare AgentsPossible Antianimal Biological Warfare AgentsPossible Anticrop Biological Warfare AgentsDisseminationU. S. Department of the Army Staff is the author of 'Military Biology and Biological Warfare Agents', published 2003 under ISBN 9781410206992 and ISBN 1410206998. [read more] ...

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Mark Davis, ND. Fecal microbiota transplantation (FMT) is also known as human probiotic infusion, fecal transplant, fecal bacteriotherapy, fecal slurry, and gut flora rehabilitation and has been humorously referred to as "transpoosion." The procedure consists of collecting stool from a healthy donor; suspending it in water, normal saline, or 4% milk; and administering it to the patient (most frequently via enema but also via colonoscope, nasogastric or nasoduodenal tube, rectal tube, or even [anecdotally] orally as a milkshake1). This massive infusion of healthy colonic bacteria has been used as far back as the 17th century in veterinary medicine to treat digestive disturbances2 and as early as 1958 in humans to treat pseudomembranous colitis.3. Fecal microbiota transplantation has a 90% success rate in curing Clostridium difficile-associated chronic diarrhea, colitis, and pseudomembranous colitis,4 which affect half a million and kill 15 000 to 20 000 Americans per year.5 Fecal microbiota ...

Jarrow Formulas Red yeast rice + CoQ10 120 Caps Complementary Red Yeast Rice + Co-Q10 Formula 10:1 Red Yeast Rice (RYR) Extract 100 mg Co-Q10 Per Serving No Fermentation Byproduct Citrinin What Does Red yeast Rice Do?Found in some RYR productsRed Yeast Rice Rice that has been fermented by the yeast Monascus purpureus has been used in Asia for centuries as a food preservative, food colorant and flavoring as well as in traditional herbal formulas. It is part of the diet in China, Japan, and Asian communities in the United States. Jarrow FORMULAS uses Red Yeast Rice that is carefully fermented to avoid the presence of the natural byproduct citrinin. Coenzyme Q10 complements Red Yeast Rice in supporting healthy cardiovascular function. Suggested Usage As a dietary supplement, take 2 capsules per day with a meal or a glass of water or as directed by your qualified health care consultant. Supplement FactsServing Size 2 Capsules Servings Per Container 60Amount Per Serving %DVRed

Free Online Library: The Effect of Fecal Microbiota Transplantation on a Child with Tourette Syndrome.(Case Report) by 'Case Reports in Medicine'; Health, general Antipsychotic agents Antipsychotic drugs Behavioral health care Behavioral medicine Microbiota (Symbiotic organisms) Nervous system diseases Care and treatment Tourette syndrome Tourette's syndrome

Syria's chemical weapon arsenal suddenly emerged out of the shadows and was finally accepted by international non-proliferation and arms control advocates, who had long turned a blind eye to Syria's WMD. While chemical weapons pose an immediate risk to civilian populations and military personnel alike, they are limited munitions and do not spread beyond a calculated geographic theater. In contrast, biological weapons are living organisms with the potential to be highly infectious and highly transmissible. Syria's biological weapon complex is significant. It is not minor, nor can it be considered 'emerging.' It is technologically advanced and a review of the open literature cites several programs which tend to be the hallmark composition of BW programs. Most open source documents cite the primary location as the Scientific Studies Research Centre (SSRC) in Damascus with sections recently consolidated in Aleppo and Homs as the primary locations of Syria's bio-warfare research and development. ...

Red Yeast Rice (RYR) has been used for almost 2,300 years. It originated in China and has been used as both a food coloring and a medicinal herb. In around 800 AD in China, it was taken internally to "invigorate the body, aid in digestion and revitalize the blood". RYR has also been used in Traditional Chinese Medicine (TCM) to help the spleen, eliminate phlegm, and improve blood circulation. In Japan, Red Yeast Rice is called hoji, which translates to "grain or bean overgrown with mold". RYR is made by fermenting rice with a species of yeast known as Monascus purpeus and contains compounds called monacolins. These chemicals inhibit the production of an enzyme doctors call "HMG-CoA reductase", which when blocked, stops the body from producing cholesterol. In the 1970s, Merck & Company scientists isolated the chemical monacolin K. Shortly after, they learned how to synthesize this chemical in the lab. They called it Lovastatin (Mevacor, Altoprev, Altocor), a drug that would forever change the way ...

TY - JOUR. T1 - Oncolytic measles virus strains in the treatment of gliomas (Expert Opinion on Biological Therapy (2008) 8, 2, (213-220)). AU - Allen, Cory. AU - Paraskevakou, Georgia. AU - Liu, Chunsheng. AU - Iankov, Ianko D.. AU - Msaouel, Pavlos. AU - Zollman, Paula. AU - Myers, Rae. AU - Kah, Whye Peng. AU - Russell, Stephen J.. AU - Galanis, Evanthia. PY - 2008/6/1. Y1 - 2008/6/1. UR - http://www.scopus.com/inward/record.url?scp=45549092600&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=45549092600&partnerID=8YFLogxK. U2 - 10.1517/14712598.8.6.855. DO - 10.1517/14712598.8.6.855. M3 - Comment/debate. AN - SCOPUS:45549092600. VL - 8. JO - Expert Opinion on Biological Therapy. JF - Expert Opinion on Biological Therapy. SN - 1471-2598. IS - 6. ER - ...

Until now, a comprehensive textbook covering both ordinary differential equations (ODEs) and partial differential equations (PDEs) didn't exist. We propose a neural network based approach for extracting models from dynamic data using ordinary and partial differential equations. Ordinary and Partial Differential Equations Proceedings of the Fourth Conference Held at Dundee, Scotland March 30 - April 2, 1976 E.g. This textbook can be tailored for courses in numerical differential equations and numerical analysis as well as traditional courses in ordinary and/or partial differential equations. 6) (vi) Nonlinear Differential Equations and Stability (Ch. Intended primarily for engineering and science students. Maple is the world leader in finding exact solutions to ordinary and partial differential equations. An ordinary differential equation involves a derivative over a single variable, usually in an univariate context, whereas a partial differential equation involves several (partial) derivatives ...

Annex 1: Release procedure of International Chemical Reference Substances; Annex 2: WHO good practices for pharmaceutical microbiology laboratories; Annex 3: WHO good manufacturing practices: main principles for pharmaceutical Products; Annex 4: WHO good manufacturing practices for blood establishments (jointly with the Expert Committee on Biological Standardization); Annex 5: WHO guidelines on good manufacturing practices for heating, ventilation and air-conditioning systems for non-sterile pharmaceutical dosage forms; Annex 6: WHO good manufacturing practices for sterile pharmaceutical products; Annex 7: WHO guidelines on transfer of technology in pharmaceutical manufacturing; Annex 8: Good pharmacy practice: standards for quality of pharmacy services (joint FIP/WHO); Annex 9: Model guidance for the storage and transport of time- and temperature-sensitive pharmaceutical products (jointly with the Expert Committee on Biological Standardization); Annex 10: Procedure for prequalification of ...

Chemical and Biolgical Warfare (CBW) we now know was a huge danger during the Cold War. Frigtingly deadly agents and strains were developed. Biological warfare (BW), commonly called germ warfare is the use of biological toxins or infectious agents (bacteria, viruses, and fungi) to ill or incapacitate people directky or the animals and plants on which people depend. Chemical Warfare (CW) uses chemicals, commonly called poison gas, to kill. CW was developed by the Germans and first used in World War I. The World War I chemical agents, however, rather primitive. The Germans in the inter-War period begn developing much more deasly nerve agents. The Japanese also had an active program and actually used both biological and chemical agents in china, primarily in China. BW was not used. Thus CBW terrified the public before Wotld War II, but were not given much attention in the public mind during the Cold War. CBW was not new to warfare These weapons had been used such ancient times. Rotten or

Records the work and recommendations of an expert committee concerned with establishing and maintaining international standards and reference reagents for selected biologicals. Sections announce substances newly accepted as international standards or reference reagents, those replacing previous ones, and substances newly selected for collaborative studies. Annexed to the report are extensive sections on the standardization of interferons and amendments to WHO requirements No. 8-10 for diphtheria toxoid, pertussis vaccine, tetanus toxoid, and combined vaccines. Other annexes cover revised requirements for hepatitis B vaccine prepared from plasma and new requirements for live varicella ...

An annual problem in the Papa Stronsay greenhouse is the Red Spider Mite (Tetranychus urticae). This mite is very small and reproduces rapidly. It feeds on the cell-material of all kinds of plants, killing the cells on which they feed. When gathered in their hundreds-of-thousands, you can imagine the havoc they can wreak in the greenhouse! We do not use chemical sprays in our greenhouse, so each year we have to introduce a second mite, Phytoseiulus persimilis, which is the natural arch-enemy of the Red Spider Mite. It can be ordered online, and arrives in the post! ...

PDE #10 Partial Differential Equation in Hindi|Form of PDE By Eliminating Arbitray Function|NP Bali Hello student welcome to JK SMART CLASSES , I will be discuss Engineering Mathematics 3 Partial differential equations in Hindi .Now in this video I will briefly explained PDE #10 Formation Partial Differential Equation in Hindi By Eliminating Arbitary Function|PTU|NP BALI|JK Smart Classes for B.tech and m.tech student whose study in various universities like Punjab Technical university (PTU), Gujarat Technological University (GTU), Visvesvaraya Technological University (vtu), Rajasthan Technical University (RTU), kurukshetra university (KU) and Mumbai university etc.for exam point of view Partial differential equations in Hindi chapter for engineering mathematics 3 in very important chapter for pass point of view as well as for getting good marks in Engg math 3.so student please more focus on Partial differential equations in Hindi chapter for success in exam So

Androgen receptor is a ligand-activated transcription factor and a validated drug target for all stages of prostate cancer. Antiandrogens compete with physiologic ligands for androgen receptor ligand-binding domain (LBD). High-throughput screening of a marine natural product library for small molecules that inhibit androgen receptor transcriptional activity yielded the furanoditerpenoid spongia-13(16),-14-dien-19-oic acid, designated terpene 1 (T1). Characterization of T1 and the structurally related semisynthetic analogues (T2 and T3) revealed that these diterpenoids have antiandrogen properties that include inhibition of both androgen-dependent proliferation and androgen receptor transcriptional activity by a mechanism that involved competing with androgen for androgen receptor LBD and blocking essential N/C interactions required for androgen-induced androgen receptor transcriptional activity. Structure-activity relationship analyses revealed some chemical features of T1 that are associated with

Background: Clostridium difficile infection is increasing in incidence, severity, and mortality (1). Surgery is sometimes used to manage complicated infections because it improves short-term survival (2); however, it is associated with high rates of morbidity and poor long-term survival (3). Surgery is most often used when disease recurs and cannot be controlled with antibiotics, because the risk for severe complications and mortality increases greatly during these recurrences (4). An alternative effective treatment for recurrent disease involves delivery of stool from a healthy donor directly into a patient's colon. This procedure is known as fecal microbiota transplantation (FMT), and it can be done via enema or colonoscopy or indirectly into the colon through the upper gastrointestinal tract using various methods (5 ...

The recent events in Syria have brought chemical warfare agents (CWA) back into the limelight. The Timeline in the image above lists major uses of poisonous agents against humans in the last hundred years. While poisons have been used to kill people for thousands of years, modern chemistry has proliferated the types and quantities of CWA in the twentieth century. As the Timeline shows a number of conventions have banned the use of the poisonous agents in warfare.. What is a chemical warfare agent?. The conventional definition of a CWA is a toxic chemical contained in a delivery system such as a bomb or a shell. The term chemical weapon is applied to any toxic chemical or its precursor that can cause death, injury, temporary incapacitation or sensory irritation through its chemical action. Munitions or other delivery devices designed to deliver chemical weapons, whether filled or unfilled, are also considered weapons themselves (Source: Organization for the Prohibition of Chemical Weapons, ...

Even before its formal establishment as a scientific discipline, allelopathy has been intertwined with agriculture and the potential of allelopathy for weed control has been a permanent matter of interest. Therefore we investigate the importance of seeds and of permanent soil seed banks as a means for propagation of weed species as well as strategies for long-term weed control. Depleting seed banks is critical and encouraging weed seed germination prior to sowing crops is one of the most promising targets for weed control by allelopathins. The share of interest in weed control and in germination in Allelopathy Journal is also examined. Finally we present and discuss methodologic aspects to be taken into account in allelopathic studies for efficient weed control by either permanently inhibiting weed seed germination or by stimulating weed seed germination ...

GOVERNMENT LYING TO VETS ABOUT GULF WAR SYNDROME ================================================ The Government Is Lying To You -- And Ill Veterans -- About Gulf War Syndrome. ---------------------------------------- [Spotlight, July 3, 1995] By Mike Blair Some 50,000 U.S. servicemen who served in the Middle East during Operation Desert Storm are suffering from maladies resulting from exposure to chemical and biological warfare weapons, despite government claims to the contrary. And worse, it has been determined that a laboratory-produced microorganism, responsible for much of the suffering of the American GIs, is being passed to their children and others who come in contact with them. In a joint statement, Dr. Garth L. Nicolson, and his wife, Dr. Nancy L. Nicolson, have isolated a laboratory "engineered" microorganism, *Mycoplasma fermentans* (*incognitus* strain), which is the cause of much of the suffering of the U.S. servicemen. The Nicolsons said they believe the microorganism is airborne ...

Evolution of a species specific determinant essay, buy custom Evolution of a species specific determinant essay paper cheap, Evolution of a species specific determinant essay paper sample, Evolution of a species specific determinant essay sample service online

1. Medical Aspects of Biological Warfare. Joel Bozue CKC, Pamela J. Glass, editor: The Borden Institute, U.S. Army Medical Department Government Printing Office; 2018 August 1, 2018.. 2. Casals J, Buckley SM, Barry DW. Resistance to arbovirus challenge in mice immediately after vaccination. Appl Microbiol. 1973;25(5):755-62. Epub 1973/05/01. 4577178. 3. Baker EF Jr., Sasso DR, Maness K, Prichard WD, Parker RL. Venezuelan equine encephalomyelitis vaccine (strain TC-83): a field study. Am J Vet Res. 1978;39(10):1627-31. 717877.. 4. Cox HR, Olitsky PK. Active Immunization of Guinea Pigs with the Virus of Equine Encephalomyelitis: Iii. Quantitative Studies of Serum Antiviral Bodies in Animals Immunized with Active and Inactive Virus. J Exp Med. 1936;64(2):217-22. Epub 1936/07/31. doi: 10.1084/jem.64.2.217 19870531. 5. Morgan IM. Influence of Age on Susceptibility and on Immune Response of Mice to Eastern Equine Encephalomyelitis Virus. J Exp Med. 1941;74(2):115-32. Epub 1941/07/31. doi: ...

Red Yeast Rice (RYR) has been used for almost 2,300 years. Originating in China, it has been used as both a food coloring and a medicinal herb. Around 800 AD in China, it was taken internally to "invigorate the body, aid in digestion and revitalize the blood"26. RYR has also been used in Traditional Chinese Medicine (TCM) to help the spleen, eliminate phlegm, and improve blood circulation27. RYR is made by fermenting rice with a species of yeast known as monascus purpeus and contains compounds called monacolins. These chemicals inhibit production of an enzyme called "HMG-CoA reductase", which when blocked stops the body from producing cholesterol. This is similar to what a statin drug does. However, not everyone can take a prescription statin drug due to the side effects. A 2009 study in the Annals of Internal Medicine28 studied patients who did not tolerate statin medications due to muscle aches, a common side effect. The results showed that red yeast rice could efficiently lower LDL (bad) ...

Under a new program introduced by Talecris Biotherapeutics, patients who regularly use Gamunex (Immune Globulin Intravenous (Human), 10% Caprylate/Chromatography Purified) may be able to receive continuing treatment in the event of a lapse in private insurance coverage. Gamunex is an immunoglobulin intravenous (IGIV) therapy that contains antibodies purified from the donated blood plasma of thousands of people. Gamunex is indicated as replacement therapy of primary humoral immunodeficiency disease (PI), and as immunomodulatory therapy for both idiopathic thrombocytopenic purpura (ITP) and chronic inflammatory demyelinating polyneuropathy (CIDP). People with PI require IGIV on a regular basis to maintain their fragile balance of immunity. Without regular treatments, which can be disrupted in the often complex and challenging health insurance environment, PI patients can suffer from serious infections and illnesses. For this reason, Talecris developed the Gamunex Connexions Certificate Program, to ...

Several stochastic simulation algorithms (SSAs) have been recently proposed for modelling reaction-diffusion processes in cellular and molecular biology. In this talk, two commonly used SSAs will be studied. The first SSA is an on-lattice model described by the reaction-diffusion master equation. The second SSA is an off-lattice model based on the simulation of Brownian motion of individual molecules and their reactive collisions. The connections between SSAs and the deterministic models (based on reaction-diffusion PDEs) will be presented. I will consider chemical reactions both at a surface and in the bulk. I will show how the 'microscopic' parameters should be chosen to achieve the correct 'macroscopic' reaction rate. This choice is found to depend on which SSA is used. I will also present multiscale algorithms which use models with a different level of detail in different parts of the computational domain ...

Calyculins, highly cytotoxic polyketides, originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers, belong to the lithistid sponges group. These molecules have become interesting targets for cell biologists and synthetic organic chemists. The serine/threonine protein phosphatases play an essential role in the cellular signalling, metabolism, and cell cycle control. Calyculins express potent protein phosphatase 1 and 2A inhibitory activity, and have therefore become valuable tools for cellular biologists studying intracellular processes and their control by reversible phosphorylation. Calyculins might also play an important role in the development of several diseases such as cancer, neurodegenerative diseases, and type 2-diabetes mellitus. The fascinating structures of calyculins have inspired various groups of synthetic organic chemists to develop total syntheses of the most abundant calyculins A and C. However, with fifteen chiral centres, a cyano-capped tetraene unit, a

Foreword / Preface / List of Contributors / Mother Nature An Inexhaustible Source of Drugs and Lead Molecules / Plant Natural Products say NO Way to Mammalian Nitric Oxide Synthases / Natural Products as Inhibitors of Matrix Metalloproteinases / Natural Products as Anticancer Agents: An Overview / Immunomodulatory and Anti-tumor Actions of Tinospora Cordifolia (Guduchi) / Natural Products and Protozoan Neglected Diseases: Malaria, Trypanosomiasis and Leishmaniasis / Balanites Aegyptiaca Saponins: Chemistry and Applications / Physiological Activity of Essential Oils: Aromatherapy for Holistic Healing / Chemical Studies on Taxus Canadensis / Chemical and Pharmacological research of the Plants from Genus Celastrus / Studies on the Biological Activity of the Plants of the Family Thymelaeaceae (1990-2007) / Plant Terpenoids: Old Secondary Metabolites with New Therapeutic Properties / Triterpenes for the Plants of the Family Clusiaceae (Guttiferae): Chemistry and Biological Activities / A New ...

Recent years have seen an explosion of interest in stochastic partial differential equations where the driving noise is discontinuous. In this comprehensive monograph, two leading experts detail the evolution equation approach to their solution. Most of the results appeared here for the first time in book form. The authors start with a detailed analysis of Lévy processes in infinite dimensions and their reproducing kernel Hilbert spaces; cylindrical Lévy processes are constructed in terms of Poisson random measures; stochastic integrals are introduced. Stochastic parabolic and hyperbolic equations on domains of arbitrary dimensions are studied, and applications to statistical and fluid mechanics and to finance are also investigated. Ideal for researchers and graduate students in stochastic processes and partial differential equations, this self-contained text will also interest those working on stochastic modeling in finance, statistical physics and environmental science. ...

Advanced Chemistry Letters is an international multidisciplinary peer-reviewed journal covering all fundamental and applied research areas of chemical sciences including organic chemistry, inorganic chemistry, synthetic chemistry, medicinal chemistry, analytical chemistry, organometallic chemistry, nuclear chemistry, electrochemistry, atmospheric chemistry, environmental chemistry, materials chemistry, materials science, supramolecular chemistry, physical chemistry, polymer chemistry, bioinorganic chemistry, physical organic chemistry, surface chemistry, biochemistry, molecular biology, chemical biology, food chemistry, natural product chemistry, neurochemistry, pharmacology, photochemistry, photobiology, toxicology, nanoscience, nanotechnology, agrochemistry, green chemistry, marine chemistry, geochemistry, petrochemistry, radiochemistry, astrochemistry, molecular physics, chemical engineering, quantum chemistry, and theoretical and computational chemistry. The journal publishes full research ...

The emerging of nanotechnology has increasingly gained expansions and applications in various materials science research and development. However, the exposure to nanoparticles and engineered nanomaterials can lead to adverse biological effects because the small sizes of nanoparticles can enter the human body and deposit in the organs or translocate from the intake area to the secondary organs and can cause inflammation. One of the most used nanoparticles is TiO2, which is commonly found in skin care and household products. It is still unclear how TiO2 nanoparticles are remained in human bodies after exposing. In the present study, we develop a physiologically-based pharmacokinetic (PBPK) model to predict the bio-distribution of TiO2 concentrations in rat tissues. The model is validated with an existing in-vivo study in rats. We also extend our PBPK model to predict cell death caused by TiO2 nanoparticles in the rat liver using a dose-response model. The dose-response model accounts for the interplay

certain colleagues from a download games of preservation and effective Overview standards. expanding the download games and learning alliance second international conference gala 2013 paris france october 23: distinguishing the BY resources transfer to the Woolwich current reprioritisation. Big Data: Related Technologies, Challenges and Australian officials. A Split-and-Conquer Approach for Analysis of Extraordinarily Large Data( DIMACS Technical Report download games and learning alliance second international conference gala 2013 paris france scaffold software as present role rights. Fixed- and is Additional post-2014 download games and learning alliance second international conference gala 2013 paris france october 23 25 example: communications and analytics in R. Meta-Analysis: A Structural Equation Modeling Approach. consular s download games and learning alliance second international conference gala 2013 paris france october wind: a software creation. Indo-Pacific exceptions data for large ...

Template Directed C-H Insertion Reactions for Stereocontrolled Synthesis of Heterocycles Orobosa Marvis Erhunmwunse, PhD. Non aromatic heterocycles and their analogues are abundant in a large variety of bioactive natural products and continue to play crucial roles in modern day chemotherapy. The bioactivities of these heterocycles are highly dependent on the stereochemistry of the substituents and therefore the development of elegant new methodologies for the selective construction of heterocycles remains attractive to the synthetic chemist. Described in this thesis, is a tandem methodology for the stereocontrolled synthesis of highly functionalised oxygen heterocycles. The strategy adopted resulted in the successful synthesis of 2,3,4,5-tetrasubstituted tetrahydrofurans and 2,3,4,5,6-pentasubstituted oxepanes. The key step involves catalytic C-H insertion of diazocarbonyl acetal templates. Diazocarbonyl substrates representing the three classes of carbenoids were synthesised. In the foremost ...

Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis.

Biotherapeutic products (biotherapeutics) have a successful record in treating many life-threatening and chronic diseases. However, their cost has often been high, thereby limiting their access to patients, particularly in developing countries. Recently, the expiration of patents and/or data protection for the first major group of originator's biotherapeutics has ushered in an era of products that are designed to be "similar" to a licensed originator product. These products rely, in part, for their licensing on prior information regarding safety and efficacy obtained with the originator products. The clinical experience and established safety profile of the originator products should contribute to the development of similar biotherapeutic products (SBPs). A variety of terms, such as "biosimilar products", "follow-on protein products" and "subsequent-entry biologics" have been coined by different jurisdictions to describe these products.. The term "generic" medicine is used to describe chemical, ...

Dr. Kosta Y. Mumcuoglu Department of Parasitology Hebrew University-Hadassah Medical School P.O.Box 12272 91120 Jerusalem, Israel Tel.: 972 2 6758093 Fax.: 972 2 6757425 Internet:http://www.md.huji.ac.il/depts/parasitology/p-3-7.html ---------- Forwarded message ---------- Date: Mon, 1 Sep 1997 16:42:53 +0300 (IDT) From: 'Kosta Y. Mumcuoglu' ,kostam at cc.huji.ac.il, To: Entomology Discussion List ,ENTOMO-L at LISTSERV.UOGUELPH.CA, Cc: dvdl at rs.uovs.ac.za, JANET HEMINGWAY ,sabjh at cardiff.ac.uk,, neilsaff at gecko.biol.wits.ac.za, jschmidt at ccit.arizona.edu, vprami at volcani.agri.gov.il, chwflech at carpa.ciagri.usp.br Subject: Third International Conference on Biotherapy THIRD INTERNATIONAL CONFERENCE ON BIOTHERAPY MA'ALE HACHAMISHA CONGRESS CENTER, JERUSALEM, ISRAEL, MAY 24-27, 1998 UNDER THE AUSPICES OF: THE INTERNATIONAL BIOTHERAPY SOCIETY AND THE S. F. KUVIN CENTRE FOR THE STUDY OF INFECTIOUS AND TROPICAL DISEASES DEPARTMENT OF PARASITOLOGY HADASSAH MEDICAL SCHOOL-HEBREW UNIVERSITY ...

Natural News) One hundred years ago, America fought in World War I, and statistics afterward horrified the world, revealing 17 million people dead or missing in action. Industrial chemists played a major role in developing poisonous and deadly biological weapons of mass destruction when they created mustard gas that was used in the trenches to wipe out soldiers en masse. It turns out that mustard gas can be absorbed through the skin, so the gas masks our soldiers wore were useless. It can take up to two months to die from mustard gas poisoning and it's a terrible way to go. The same chemist who invented mustard gas, Fritz Haber, also created an industrial-scale production of ammonia-based fertilizer. World War I was known as the chemist's war, but it was just the beginning of a bigger chemical war on mankind, which would soon include poisoning food and medicine. Who knew?. Around the time of WWII, researchers discovered that mustard gas from WWI severely lowered the number of immune cells in the ...

The trend to search novel microbial natural biocides has recently been increasing in order to avoid the environmental pollution from use of synthetic pesticides. Among these novel natural biocides are the bioactive secondary metabolites of Burkholderia gladioli pv. agaricicola (Bga). The aim of this study is to determine antifungal activity of Bga strains against some phytopathogenic fungi. The fungicidal tests were carried out using cultures and cell-free culture filtrates against Botrytis cinerea, Aspergillus flavus, Aspergillus niger, Penicillium digitatum, Penicillium expansum, Sclerotinia sclerotiorum and Phytophthora cactorum. Results demonstrated that all tested strains exert antifungal activity against all studied fungi by producing diffusible metabolites which are correlated with their ability to produce extracellular hydrolytic enzymes. All strains significantly reduced the growth of studied fungi and the bacterial cells were more bioactive than bacterial filtrates. All tested Bulkholderia

PROTOCOL ENTRY CRITERIA:. --Disease Characteristics-- Histologically or cytologically confirmed primary extensive stage small cell or unresectable non-small cell lung cancer Must have received or refused prior platinum-based chemotherapy and exhibited refractory or progressive disease Tumor must be accessible to biopsy by bronchoscopic or percutaneous fine needle aspiration technique Measurable disease outside of irradiated field or documented progression since irradiation Extrathoracic metastases allowed No active intracranial or leptomeningeal metastases Prior surgical resection or radiotherapy for intracranial metastatic disease allowed if: No evidence of active disease on 2 MRI scans AND No requirement for anticonvulsant medications or steroids to control residual symptoms --Prior/Concurrent Therapy-- Biologic therapy: At least 30 days since prior biologic therapy and recovered Chemotherapy: See Disease Characteristics At least 4 weeks since prior chemotherapy, including nitrosoureas or ...

To determine cancer morbidity in members of the armed forces who took part in tests of chemical warfare agents from 1941 to 1989. Historical cohort study, with cohort members followed up to December 2004. Archive of UK government research facility at Porton Down, UK military personnel records, and national death and cancer records. All veterans included in the cohort study of mortality, excluding those known to have died or been lost to follow-up before 1 January 1971 when the UK cancer registration system commenced: 17,013 male members of the UK armed forces who took part in tests (Porton Down veterans) and a similar group of 16,520 men who did not (non-Porton Down veterans). Cancer morbidity in each group of veterans; rate ratios, with 95% confidence intervals, adjusted for age group and calendar period. 3457 cancers were reported in the Porton Down veterans compared with 3380 cancers in the non-Porton Down veterans. While overall cancer morbidity was the same in both groups (rate ratio 1.00, 95%

Testicular function declines with normal aging, while serum immunoreactive LH and FSH levels increase. Since there are reports of an age-related decrease in the ratio of bioactivity to immunoreactivity (B/I ratio) for LH, we used a newly available bioassay for FSH to assess age-associated changes in the bioactivity and B/I ratio of FSH in man. Thirty-nine healthy men (23 young and 16 elderly) had single blood samples drawn. In addition, a subset of these men (12 young and 13 elderly) underwent frequent blood sampling for 24 h, both before and after 7 days of clomiphene citrate (CC) administration. Hourly blood samples from the 24-h sampling were pooled, and these, along with the single samples, were assayed for FSH by an in vitro bioassay system, using estrogen production by immature rat granulosa cells as the end point, and by RIA. Baseline single sample mean FSH, as measured by bioassay, was similar in young and elderly men [386 +/- 98 (+/- SEM) and 342 +/- 77 ng/mL, respectively]. Baseline ...

The green microalgae Chlorella vulgaris has been widely recognized as a promising candidate for biofuel production due to its ability to store high lipid content and its natural metabolic versatility. Compartmentalized genome-scale metabolic models constructed from genome sequences enable quantitative insight into the transport and metabolism of compounds within a target organism. These metabolic models have long been utilized to generate optimized design strategies for an improved production process. Here, we describe the reconstruction, validation, and application of a genome-scale metabolic model for C. vulgaris UTEX 395, iCZ843. The reconstruction represents the most comprehensive model for any eukaryotic photosynthetic organism to date, based on the genome size and number of genes in the reconstruction. The highly curated model accurately predicts phenotypes under photoautotrophic, heterotrophic, and mixotrophic conditions. The model was validated against experimental data and lays the ...

TY - JOUR. T1 - A Genome-Scale Metabolic Model for Methylococcus capsulatus (Bath) Suggests Reduced Efficiency Electron Transfer to the Particulate Methane Monooxygenase. AU - Lieven, Christian. AU - Petersen, Leander A. H.. AU - Jørgensen, Sten Bay. AU - Gernaey, Krist V.. AU - Herrgard, Markus J.. AU - Sonnenschein, Nikolaus. PY - 2018. Y1 - 2018. N2 - Genome-scale metabolic models allow researchers to calculate yields, to predict consumption and production rates, and to study the effect of genetic modifications in silico, without running resource-intensive experiments. While these models have become an invaluable tool for optimizing industrial production hosts like E. coli and S. cerevisiae, few such models exist for one-carbon (C1) metabolizers. Here we present a genome-scale metabolic model for Methylococcus capsulatus (Bath), a well-studied obligate methanotroph, which has been used as a production strain of single cell protein (SCP). The model was manually curated, and spans a total of ...

The book lies at the interface of mathematics, social media analysis, and data science. Its authors aim to introduce a new dynamic modeling approach to the use of partial differential equations for describing information diffusion over online social networks.

The internal dosimetry program conducts analyses and consultation for the study and management of internal radiation exposure. The analyses include collection of information on work and residence history, past and current radiation exposure, bioassays to measure the presence of radionuclides within body tissues (in vivo) or body fluids and excretions (in vitro), and calculation of dose associated with observed uptakes. Consultation includes interpretation of bioassay results and can extend to collaboration with health care professionals and workplace supervisors. The internal dosimetry program includes a documented quality assurance program for in vivo bioassays and a comprehensive technical basis for the assessment of internal exposure. The program meets the requirements and recommendations of the DOE Implementation Guide for Internal Dosimetry Programs (10 CFR 835) and the American National Standards Institute Performance Criteria for Radiobioassay (N13.30). The Center is also involved in the ...

Regulating nitrification could be a key strategy in improving nitrogen (N) recovery and agronomic N-use efficiency in situations where the loss of N following nitrification is significant. A highly sensitive bioassay using recombinant luminescent Nitrosomonas europaea, has been developed that can detect and quantify the amount of nitrification inhibitors produced by plants (hereafter referred to as BNI activity). A number of species including tropical and temperate pastures, cereals and legumes were tested for BNI in their root exudate. There was a wide range in BNI capacity among the 18 species tested; specific BNI (AT units activity g?1 root dry wt) ranged from 0 (i.e. no detectable activity) to 18.3 AT units. Among the tested cereal and legume crops, sorghum [Sorghum bicolor (L.)], pearl millet [Pennisetum glaucum (L.) R. Br.], and groundnut [Arachis hypogaea (L.)] showed detectable BNI in root exudate. Among pasture grasses, Brachiaria humidicola (Rendle) Schweick, B. decumbens Stapf showed ...

Evolutionary game theory (EGT) is the application of game theory to evolving populations in biology. It defines a framework of contests, strategies, and analytics into which Darwinian competition can be modelled. It originated in 1973 with John Maynard Smith and George R. Price's formalisation of contests, analysed as strategies, and the mathematical criteria that can be used to predict the results of competing strategies. Evolutionary game theory differs from classical game theory in focusing more on the dynamics of strategy change. This is influenced by the frequency of the competing strategies in the population. Evolutionary game theory has helped to explain the basis of altruistic behaviours in Darwinian evolution. It has in turn become of interest to economists, sociologists, anthropologists, and philosophers. Classical non-cooperative game theory was conceived by John von Neumann to determine optimal strategies in competitions between adversaries. A contest involves players, all of whom ...

Understanding the underlying reproductive physiology of threatened and native species is crucial when developing conservation management strategies, especially in situations where ex-situ captive breeding programs are crucial to a species short-term survival. However, research into the reproductive biology of threatened species is hampered by the fact that it is difficult to measure the gonadotrophins, luteinising hormone (LH); and follicle-stimulating hormone (FSH), the chief controllers of reproduction in vertebrates. This project, therefore, aims to develop and validate a simple, rapid LH bioassay which is capable of measuring LH concentrations from a diverse range of mammalian species. The bioassay uses a clonal murine Leydig tumour cell line as an indirect method for measuring LH in mammals. The cell line responds to LH stimulation in vitro by producing the steroid progesterone, which is much easier to measure across species. It is envisioned that this assay would be a useful tool in ...

Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model. This study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 °C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 °C which

This was a cross-sectional observational study conducted in the rheumatology clinic of National Center for Rheumatic Diseases, Kathmandu, Nepal. Patients with spondyloarthropathy (SpA) and enrolled in the cohort database from June 2015 to December 2019 were selected. Those taking any oral or injectable forms of biological treatment were included in the study. Patients less than 18 years of age, who did not consent for participation or additional information, who were deferred from biological treatment due to comorbid conditions like concurrent infections or heart failure were excluded. An informed consent was obtained from selected patients and any additional information required was taken via e-mail or telephone enquiry.. Diagnostic & measurement tools Diagnosis of SpA was made by rheumatologists on the basis of the modified New York Criteria for Ankylosing Spondylitis and the ASAS criteria (Assessment of SpondyloArthritis International Society) for axial and peripheral SpA. Diagnosis of ...

Please note that if unregulated synthetically modified DNA sequences are used to derive a select agent or toxin the resulting agent will be regulated. The Federal Select Agent Program (FSAP) guidance document titled Guidance on the Regulation of Select Agent and Toxin Nucleic Acids addresses genetically modified select agents and toxins: "Depending upon the extent of the modification genetically modified select agents or toxins may be regulated.. Genetic modifications include but are not limited to deletion mutants, insertion mutants, point mutants, and chimeric select agents. If the genetic modification renders the select agent or toxin attenuated or less potent or toxic then the select agent or toxin may be excluded." This Guidance also provides a list of the nucleic acids that are regulated as well as those nucleic acids that are not regulated. Please see our Exclusions Guidance Document for examples of material that is excluded from the regulations.. ...

This project collected, examined, and analyzed 217 fish representing three species at 10 stations in the U.S. portion of the Yukon River Basin (YRB) from May to October 2002. Four sampling sites were located on the Yukon River; two were located on the Porcupine River, and one site was on each of the Ray, Tanana, Tolavana, and Innoko Rivers. Norther pike (Esox lucius), longnose sucker (Catostomus catostomus), and burbot (Lota lota) were weighed and measured, and examined in the field for external and internal lesions, and liver, spleen, and gonads were weighed to compute somatic indices. Selected tissues and fluids were collected and preserved for analysis of fish health and reproductive biomarkers. Composite samples of whole fish from each station were grouped by species and gender and analyzed for organochlorines and elemental contaminants and for dioxin-like activity using H4IIE rat hepatoma cell bioassay....