The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity. However, the first generation of these devices had no positive impact on the mortality after PCI (compared to bare metal stents), which was greatly attributed to a somewhat increased incidence of late and very late stent thrombosis. Concerns about the role of durable polymers as a potential trigger of inflammation and finally adverse events also led to the development of DES with biodegradable coatings, which leave after degradation of the coating only a bare metal stent in the vessel wall that does not induce an inflammatory response. While such biodegradable polymer DES are increasingly used in clinical practice, there is no data available from head-to-head comparisons between biodegradable and contemporary third generation durable polymer DES ...
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity. However, the first generation of these devices had no positive impact on the mortality after PCI (compared to bare metal stents), which was greatly attributed to a somewhat increased incidence of late and very late stent thrombosis. Concerns about the role of durable polymers as a potential trigger of inflammation and finally adverse events also led to the development of DES with biodegradable coatings, which leave after degradation of the coating only a bare metal stent in the vessel wall that does not induce an inflammatory response. While such biodegradable polymer DES are increasingly used in clinical practice, there is no data available from head-to-head comparisons between biodegradable and contemporary third generation durable polymer DES ...
There was an increased risk of stent thrombosis with first-generation DES that led to the development of DES with biocompatible polymers and more recently biodegradable polymers and bioabsorbable vascular scaffolds. We have shown compelling data for safety and efficacy of second-generation DES with biocompatible polymers in a large spectrum of patients including those at high risk for stent thrombosis (3). The newer DES with bioabsorbable/biodegradable polymers and stents that allow for complete dissolution of polymer or bioscaffold leaving either a residual metal platform or native vessel would, in theory, reduce the rates of stent thrombosis. Biodegradable polymer biolimus-eluting stents were perceived to be safer than first-generation sirolimus-eluting stents on the basis of the results of individual trials that were powered for only composite endpoints of safety and efficacy. However, in the largest mixed comparison meta-analysis of ,61 trials involving 63,242 patients, there was a ...
The completion of a randomized clinical trial (RCT) requires extensive effort and resources. Like Schuberts eighth "Unfinished Symphony," which had an expansive first movement that was evidently unsustainable for 3 additional movements (1), RCTs often have a great start but sometimes struggle to get completed.. In this issue of JACC: Cardiovascular Interventions, Nakamura et al. (2) report the results of the NIPPON (Nobori Dual Antiplatelet Therapy as Appropriate Duration) trial, which was stopped prematurely because of poor enrollment. The NIPPON trial tested the hypothesis that 6 months of dual antiplatelet therapy (DAPT) was noninferior to 18 months after implantation of biodegradable polymer drug-eluting stents (DES). The primary composite endpoint of all-cause mortality, myocardial infarction, stroke, and major bleeding occurred in 2.1% of patients receiving short-term DAPT and in 1.5% receiving long-term DAPT (difference 0.6%; 95% confidence interval [CI]: 1.5% to 0.3%). Because the lower ...
News and information on minimally invasive coronary disease therapies, covering valvular, structural, radial access, chronic total occlusion, and imaging issues.
As a leader in domestic plastics industry, Kingfa Sci & Tech Co., Ltd. mainly produces modified plastics, specialty engineering plastics, completely biodegradable plastics, carbon fiber and composite materials, of which, the 30 kt/a PBS and polybutylene succinate adipate (PBSA) has been put into operation in Zhuhai in 2011, the Phase II 90 kt/a PBSA expansion project will be launched. Meanwhile, Kingfa is also increasing intensity of downstream demand expansion. The company has signed biodegradable plastic mulch demonstrative application agreements with Xinjiang Production and Construction Corps, Guizhou, Shandong and other provinces and cities in early 2014 ...
This registry-based cohort study compared outcomes of percutaneous coronary intervention patients who received biodegradable-polymer biolimus-eluting stents
Plastics that decompose in the nature by the action of microorganisms are generally referred as biodegradable plastics. These plastics are divided into different categories such as bio-based and petro-based biodegradable plastics.
Our history and philosophy - ECM BioFilms is an Ohio Corporation founded in 1998 to develop and market a new technology to produce biodegradable* plastic products which can be priced competitively.
Methods: The COMPARE II trial was an investigator-initiated, multicenter, open-label, randomized, all-comers trial which assigned patients undergoing percutaneous coronary intervention (PCI) in a 2:1 fashion to either BES or EES.We analyzed the safety and efficacy outcomes in diabetic patients at 5 year follow-up. The primary pre-specified composite endpoint major adverse cardiac event (MACE) was defined as cardiac death, non-fatal target-vessel myocardial infarction (TV-MI), or clinically indicated target vessel revascularization (CD-TVR ...
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How to manufacture biodegradable plastic? It can be manufactured by incorporating EPIs biodegradable additive, Totally Degradable Plastic Additives (TDPA), into plastic resins. The process is simple and cost effective.
The Report Synthetic And Bio-Based Biodegradable Plastics - Global Industry Analysis, Market Size, Applications, Share, Growth And Forecast, 2011 - 2018 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz
... on Wyss Institute | Wyss Institute researchers have developed a fully degradable bioplastic by isolating a material called…
The Global Biodegradable Plastics market is valued at $1.8 billion in 2014 and is expected to reach $4.2 billion by 2022 growing at a CAGR of 11.2% during...
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MIT chemists have determined the structure of a bacterial enzyme that can produce biodegradable plastics, an advance that could help chemi
The present study highlights the noninferiority of the biodegradable polymer BES compared with the durable polymer SES and, although not powered for superiority, demonstrated a trend toward clinical superiority (p = 0.069) (Fig. 2A). In addition, the findings of the study of a significant reduction in the more robust and unequivocal POCE of all-cause death, all MI, or all-cause revascularization, in subjects implanted with biodegradable polymer BES, lends further support to its increased safety compared with the durable polymer SES.. The other most notable finding of the study was the increased safety of the biodegradable polymer BES, compared with the durable polymer SES, secondary to a significant reduction in very late (,1 year) ST and its associated clinical outcomes. A finding that continued out to 5 years, with the curves continuing to separate (Fig. 4). In addition, the incidence of ST associated with the biodegradable polymer BES appeared to have almost plateaued.. Despite the findings ...
... , Ph.D., Research Fellow at Procter & Gamble, is the recipient of the 2015 INDA Lifetime Technical Achievement Award. His career involvement and commitment to bringing science-based approaches to issues in the nonwovens industry is a critical factor in earning him this award. Federle led research to modify existing aerobic and anaerobic biodegradation tests to assess flushable substrates and pioneered the early use of the shake flask to evaluate dispersibility of flushable products. These tests became part of the WERF Protocols to Assess the Breakdown of Flushable Consumer Products published in 2003 and formed the basis for development of the Flushability Assessment Test Guidelines, Editions 1, 2, and 3, and now under development, Edition 4. This market category has become one of the faster growing wipes categories, and Federles work has been instrumental in providing an effective means of measuring behavioral and disintegration properties for proper disposal of these ...
The Promus ELITE Stent System builds on the proven outcomes of almost 10,000 patients in 11 clinical trials of permanent polymer coronary stents
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Right now, 8% of the worlds oil is used to make plastics - and oil has to be extracted from the belly of the earth using extremely energy and cost-intensive processes. At the same time, the worlds cities are constantly growing and producing more waste, which is usually dehydrated and trucked off to be dumped. In a planet-positive double-whammy, Micromidas has figured out how to transform raw sewage into a versatile form of plastic that biodegrades in 6-12 months. The new company (theyve only been around since mid-2008) accomplished the feat by harnessing microbes - specifically, bacteria - to produce a bioplastic resin, which can be processed into a malleable plastic ...
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... : Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production ...
Because of this shifting production trend, European Bioplastics is calling European policy makers to do something about it and make biobased product markets as key priority in their industrial policy highlights.. In other recent bioplastic market reports, Transparency Market Research also released its new study stating that the global synthetic and bio-based biodegradable plastics market was worth $2.3bn in 2011 and is expected to reach $7.8bn in 2018, growing at an aggregate growth rate of 19.5% within the period.. Europe is said to continue leading the market in terms of revenue, and will account for 37% of the global market revenue share in 2018. Asia Pacific, meanwhile is expected to grow at 26% from 2011 to 2018 in terms of market share.. I guess this next study will dampen bioplastics good news as according to Germanys Federal Environment Agency (UBA), the overall ecological benefits of renewable-based biodegradable plastics used in packaging is no better than traditional petroleum-based ...
Brazilian jiu jitsu teaches confidence, boosts self-confidence and teaches effective self-defense moves. For those who are not interested to take up bjj class Scarborough for ...
Leeb, Christine ; Leitner, Rita ; Pichler, Verena ; Huber-Gries, Carina ; Rünzler, Dominik ; Jesenberger, Veronika (2016) Einführung und Optimierung eines praxisorientierten Problem-based-Learning-Moduls im Life-Science-Bereich ZFHE, Zeitschrift für Hochschulentwicklung, Jg.11 / Nr.3 (Mai 2016): S. 107-121. - https://www.zfhe.at/index.php/zfhe/article/view/897) Teuschl, Andreas Herbert ; Schuh, Christina Maria Anna Pia ; Halbweis, Robert ; Pajer, Krisztian ; Marton, Gabor ; Hopf, Rudolf ; Mosia, Shorena ; Rünzler, Dominik ; Redl, Heinz ; Nogradi, Antal ; Hausner, Thomas (2015) A new preparation method for anisotropic silk fibroin nerve guidance conduits and its evaluation in vitro and in a rat sciatic nerve defect model Tissue Engineering Part C: Methods / 2015 / vol. 21 / no. 9 / p. 150328090920000 / ISSN 1937-3384 / DOI 10.1089/ten.TEC.2014.0606. Heher, Philipp ; Maleiner, Babette ; Prüller, Johanna ; Teuschl, Andreas Herbert ; Kollmitzer, Josef ; Monforte, Xavier ; Wolbank, Susanne ; ...
October 30, 2016 -- Dublin and Washington -- Investigators today unveiled clinical data from the independent BIO-RESORT study, representing the first all-comers analysis to compare the safety and efficacy of biodegradable polymer stents (BP-DES) to durable polymer Resolute™ Integrity™ drug-eluting stent (DP-DES) from Medtronic plc (NYSE: MDT). At one year, patients with coronary artery disease who were treated with a biodegradable polymer stent showed no clinical benefits over patients treated with Resolute Integrity. The highly-anticipated results were presented today during a Late-Breaking Clinical Trial session at the Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting and simultaneously published in The Lancet. As authors write in The Lancet manuscript, "Neither of these [biodegradable] stents have [previously] been compared with the new-generation thin-strut durable polymer zotarolimus-eluting stent (Resolute Integrity, Medtronic, Santa Rosa, CA, USA) - an established device ...
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The management of fishery residues and plastics is considered to be a vital strategy for conserving resources and maintaining the quality of the environment. Poly(l-lactic acid) (PLA) is a commercially promising, renewable, and biodegradable plastic. In this study, a PLA depolymerase was produced in a squid pen powder (SPP) and recycled plastic waste (PLA powder)-containing medium by Pseudomonas tamsuii TKU015, a bacterial strain isolated from Taiwanese soil. This PLA depolymerase had a molecular weight of 58 kDa and was purified to homogeneity from the supernatant of a TKU015 culture. The optimum pH of TKU015 PLA depolymerase is 10, and the optimal temperature of the enzyme is 60 °C. In addition to PLA, TKU015 PLA depolymerase degraded fibrinogen and tributyrin, but did not hydrolyze casein, triolein, and poly(β-hydroxybutyrate). Taken together, these data demonstrate that P. tamsuii TKU015 produces a PLA depolymerase to utilize SPP and polylactide as carbon/nitrogen sources.
Articles manufactured with a composition comprising a polymer of an unsaturated hydrocarbon, a C1-4 alkyl or hydroxyalkylether of starch having a degree of substitution of at least 0.25, and a polyhydric aliphatic alcohol having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; wherein the compatibilizing agent can be a vinyl copolymer, acrylic copolymer and mixtures thereof. The composition can be used in the preparation of biodegradable plastics.
A student from Englands University of Sussex has won about $40,000 for the invention of a translucent and biodegradable plastic made entirely from fish leftovers. Lucy Hughes hopes the grant from the James Dyson Award will help jumpstart her MarinaTex into large-scale production. Matthew Larotonda reports.
This will knock you out. Im sending you something Ive just found called Leaves.â„¢ Its a new product from Past Toyz in Shanghai featuring a giant biodegradable plastic bag containing real farm grown leaves that have been hygienically dried and treated with an anti-bacterial agent for safe outdoor fun â„¢ Can you believe it? Why didnt we think of that? I think the idea is that you empty the bag in your backyard and play with the leaves. Either that or you can drive that hygiene and order fixated neighbor or yours crazy by placing a single leaf on his plastic lawn every night for the next two years. I suppose the company did some research with Maverns and Connectors that said that people in urban areas arent getting as close to nature as they like. Back in my day leaves grew on trees but the colours werent manipulated and the bugs were kept in check by other bugs not chemicals. Anyway, it certainly made me laugh. You can always send it back if the joke is lost on you ...
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Local Darwin weather has been relatively quiet since the project was completed in November 2006, with the rain in the period up to late February relatively low, by local standards, and no major storm events. But, over the period March 1, 2007 through 6 March, that changed - with over 500 mm in this period with about 90% falling in the three days 3-5 March. The area flooded, with around 300mm across the road, although relatively slow moving, and the road was closed, except for large 4WD and trucks on Saturday and Sunday. ...
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An input evaluation system for evaluating an operation input of an operator, including: a drawing section which generates an image which seems to have a depth, a first moving object moving in an objec
The rapid scale up of the response has been accompanied by an increasing emphasis on measurable indicators and results. These include programme monitoring data, behavioural and biological trends data and evaluation of programmes. The increasing demands on country monitoring and evaluation systems can only be met if better systems are built and supported.
Microbial degradation: The primary purpose of biodegradable plastics is to replace traditional plastics that persist in landfills and harm the environment. Therefore, the ability of microorganisms to break down these plastics is an incredible environmental advantage. Microbial degradation is accomplished by 3 steps: colonization of the plastic surface, hydrolysis, and mineralization. First, microorganisms populate the exposed plastics. Next, the bacteria secrete enzymes that bind to the carbon source or polymer substrates and then split the hydrocarbon bonds. The process results in the production of H2O and CO2. Despite the release of CO2 into the environment, biodegradable plastics leave a smaller footprint than petroleum-based plastics that accumulate in landfills and cause heavy pollution, which is why they are explored as alternatives to traditional plastics.[19]. Municipal solid waste: According to a 2010 report of the United States Environmental Protection Agency (EPA) the US had 31 ...
COVID-19 Outbreak-Global Biodegradable Plastics Industry Market Report-Development Trends, Threats, Opportunities and Competitive Landscape in 2020 is a market research report available at US $3660 for a Single User PDF License from RnR Market Research Reports Library.
Cell transplantation using bone marrow stromal cells (BMSCs) to alleviate neurological deficits has recently become the focus of research in regenerative medicine. Evidence suggests that secretion of various growth-promoting substances likely plays an important role in functional recovery against neurological diseases. In an attempt to identify a possible mechanism underlying the regenerative potential of BMSCs, this study investigated the production and possible contribution of neurotrophic factors by transected sciatic nerve defect in a rat model with a 15 mm gap. Cultured BMSCs became morphologically homogeneous with fibroblast-like shape after ex vivo expansion. We provided several pieces of evidence for the beneficial effects of implanted fibroblast-like BMSCs on sciatic nerve regeneration. When compared to silicone tube control animals, this treatment led to (i) improved walking behavior as measured by footprint analysis, (ii) reduced loss of gastrocnemius muscle weight and EMG magnitude, ...
Were privy to a wide selection of orange varieties grown locally here in Southern California. Everything from the pedestrian navel orange to the gourmet blood orange. And theyre all good. But the flavor from this Satsuma from Chaffin Family Orchards is unique. Pungent, explosive, fantastic.. And the juice. As I was pressing some juice for the Chinese Mandarin Orange Chicken recipe, I sampled some. Wow! Once youve had this juice, you can never go back to Tropicana.. Notes on This Recipe. This recipe is different from most recipes youll find for Chinese Orange Chicken. I used a healthy, traditional fat - lard. Unlike what you read in books like The China Study, lard, or pig fat, has traditionally been used in China for thousands of years (Source). I also used a traditional, unrefined sweetener - honey. And I used whole grain sprouted flour instead of refined white flour.. If you cant find lard, beef tallow would also be very good in this recipe. If you use coconut oil, make sure it is the ...
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There are 70 calories in 1 cup (8.1 fl.oz) of AriZona Mandarin Orange Green Tea. Youd need to walk 18 minutes to burn 70 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
Researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard and Harvard Medical School have engineered photosynthetic bacteria to produce simple sugars and lactic acid. This innovation could lead to new, environmentally friendly methods for producing commodity chemicals in bulk. Their research findings appear in the current issue of Applied and Environmental Biology.. This photosynthetic factory could also reduce the carbon dioxide emissions associated with transporting sugar globally from producing countries; lead to greater availability of biodegradable plastics; and allow capture of harmful CO2 emissions from power plants and industrial facilities.. In addition to its positive environmental impact, the technology offers potential economic advantages. Because the production methods use photosynthesis - the process by which living things are assembled using only CO2 and sunlight - the cost of making sugars, lactic acid, and other compounds would be significantly lower ...
The teams target molecule? Malic acid - one of the stars of the DOEs Top 12 Biobased Molecules list. Malate has many direct uses and can be used in the manufacture of materials such as biodegradable plastics, fiberglass, and fabrics. But its been relaatively overlooked - compared, say, to the interest shown on biosuccinic acid.. The one development to date of interest had been the news from August 2012 that Novozymes announced a fungus enabling production of malic acid from renewable raw materials instead of oil.. Malic acid is used as a flavor enhancer in the food industry and can be converted into other chemical derivatives used for a variety of plastic, polymer and resin products. Along with succinic acid and fumaric acid it belongs to the group of C4 dicarboxylic acids. C4 acids can be converted into 1.4-butanediol (BDO) that can be further converted into numerous chemicals, including plastics, polymers and resins for use in everything from golf balls and skateboard wheels to printing ...
Joint BioEnergy Institute researchers develop CAD-Type tools for engineering RNA control systems. The computer assisted design (CAD) tools that made it possible to fabricate integrated circuits with millions of transistors may soon be coming to the biological sciences. Researchers at the U.S. Department of Energy (DOE)s Joint BioEnergy Institute (JBEI) have developed CAD-type models and simulations for RNA molecules that make it possible to engineer biological components or "RNA devices" for controlling genetic expression in microbes. This holds enormous potential for microbial-based sustainable production of advanced biofuels, biodegradable plastics, therapeutic drugs and a host of other goods now derived from petrochemicals.. "Because biological systems exhibit functional complexity at multiple scales, a big question has been whether effective design tools can be created to increase the sizes and complexities of the microbial systems we engineer to meet specific needs," says Jay Keasling, ...