Fingerprint Dive into the research topics of Stent thrombosis with bioabsorbable polymer drug-eluting stents: insights from the Food and Drug Administration database. Together they form a unique fingerprint. ...

The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity. However, the first generation of these devices had no positive impact on the mortality after PCI (compared to bare metal stents), which was greatly attributed to a somewhat increased incidence of late and very late stent thrombosis. Concerns about the role of durable polymers as a potential trigger of inflammation and finally adverse events also led to the development of DES with biodegradable coatings, which leave after degradation of the coating only a bare metal stent in the vessel wall that does not induce an inflammatory response. While such biodegradable polymer DES are increasingly used in clinical practice, there is no data available from head-to-head comparisons between biodegradable and contemporary third generation durable polymer DES ...

The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity. However, the first generation of these devices had no positive impact on the mortality after PCI (compared to bare metal stents), which was greatly attributed to a somewhat increased incidence of late and very late stent thrombosis. Concerns about the role of durable polymers as a potential trigger of inflammation and finally adverse events also led to the development of DES with biodegradable coatings, which leave after degradation of the coating only a bare metal stent in the vessel wall that does not induce an inflammatory response. While such biodegradable polymer DES are increasingly used in clinical practice, there is no data available from head-to-head comparisons between biodegradable and contemporary third generation durable polymer DES ...

There was an increased risk of stent thrombosis with first-generation DES that led to the development of DES with biocompatible polymers and more recently biodegradable polymers and bioabsorbable vascular scaffolds. We have shown compelling data for safety and efficacy of second-generation DES with biocompatible polymers in a large spectrum of patients including those at high risk for stent thrombosis (3). The newer DES with bioabsorbable/biodegradable polymers and stents that allow for complete dissolution of polymer or bioscaffold leaving either a residual metal platform or native vessel would, in theory, reduce the rates of stent thrombosis. Biodegradable polymer biolimus-eluting stents were perceived to be safer than first-generation sirolimus-eluting stents on the basis of the results of individual trials that were powered for only composite endpoints of safety and efficacy. However, in the largest mixed comparison meta-analysis of ,61 trials involving 63,242 patients, there was a ...

The completion of a randomized clinical trial (RCT) requires extensive effort and resources. Like Schuberts eighth Unfinished Symphony, which had an expansive first movement that was evidently unsustainable for 3 additional movements (1), RCTs often have a great start but sometimes struggle to get completed.. In this issue of JACC: Cardiovascular Interventions, Nakamura et al. (2) report the results of the NIPPON (Nobori Dual Antiplatelet Therapy as Appropriate Duration) trial, which was stopped prematurely because of poor enrollment. The NIPPON trial tested the hypothesis that 6 months of dual antiplatelet therapy (DAPT) was noninferior to 18 months after implantation of biodegradable polymer drug-eluting stents (DES). The primary composite endpoint of all-cause mortality, myocardial infarction, stroke, and major bleeding occurred in 2.1% of patients receiving short-term DAPT and in 1.5% receiving long-term DAPT (difference 0.6%; 95% confidence interval [CI]: 1.5% to 0.3%). Because the lower ...

News and information on minimally invasive coronary disease therapies, covering valvular, structural, radial access, chronic total occlusion, and imaging issues.

Background: It is important to determine the best drug-eluting stent (DES) for acute myocardial infarction (AMI) in patients with renal impairment. In this studythe outcomes of everolimus-eluting stents (EESs), zotarolimus-eluting stents (ZESs) and biolimus-eluting stents (BESs) were evaluated.. Methods: From the Korea Acute Myocardial Infarction-National Institutes of Health registry, a total of 1,470 AMI patients with renal impairment undergoing percutaneous coronary intervention (PCI) were enrolled (816 with EES, 345 with ZES, and 309 with BES). Renal impairment was defined as creatinine clearance , 60 mL/min/1.73 m2 estimated by the Cockcroft-Gault method. Major adverse cardiac and cerebrovascular events were determined as the composite of all-cause death, non-fatal myocardial infarction (MI), cerebrovascular accident, any revascularization, rehospitalization and stent thrombosis. All clinical outcomes were analyzed.. Results: The baseline characteristics of the patients revealed no ...

As a leader in domestic plastics industry, Kingfa Sci & Tech Co., Ltd. mainly produces modified plastics, specialty engineering plastics, completely biodegradable plastics, carbon fiber and composite materials, of which, the 30 kt/a PBS and polybutylene succinate adipate (PBSA) has been put into operation in Zhuhai in 2011, the Phase II 90 kt/a PBSA expansion project will be launched. Meanwhile, Kingfa is also increasing intensity of downstream demand expansion. The company has signed biodegradable plastic mulch demonstrative application agreements with Xinjiang Production and Construction Corps, Guizhou, Shandong and other provinces and cities in early 2014 ...

This registry-based cohort study compared outcomes of percutaneous coronary intervention patients who received biodegradable-polymer biolimus-eluting stents

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Plastics that decompose in the nature by the action of microorganisms are generally referred as biodegradable plastics. These plastics are divided into different categories such as bio-based and petro-based biodegradable plastics.

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Methods: The COMPARE II trial was an investigator-initiated, multicenter, open-label, randomized, all-comers trial which assigned patients undergoing percutaneous coronary intervention (PCI) in a 2:1 fashion to either BES or EES.We analyzed the safety and efficacy outcomes in diabetic patients at 5 year follow-up. The primary pre-specified composite endpoint major adverse cardiac event (MACE) was defined as cardiac death, non-fatal target-vessel myocardial infarction (TV-MI), or clinically indicated target vessel revascularization (CD-TVR ...

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How to manufacture biodegradable plastic? It can be manufactured by incorporating EPIs biodegradable additive, Totally Degradable Plastic Additives (TDPA), into plastic resins. The process is simple and cost effective.

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Shrilk Biodegradable Plastic on Wyss Institute | Wyss Institute researchers have developed a fully degradable bioplastic by isolating a material called…

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The Global Biodegradable Plastics market is valued at $1.8 billion in 2014 and is expected to reach $4.2 billion by 2022 growing at a CAGR of 11.2% during...

MIT chemists have determined the structure of a bacterial enzyme that can produce biodegradable plastics, an advance that could help chemi

The present study highlights the noninferiority of the biodegradable polymer BES compared with the durable polymer SES and, although not powered for superiority, demonstrated a trend toward clinical superiority (p = 0.069) (Fig. 2A). In addition, the findings of the study of a significant reduction in the more robust and unequivocal POCE of all-cause death, all MI, or all-cause revascularization, in subjects implanted with biodegradable polymer BES, lends further support to its increased safety compared with the durable polymer SES.. The other most notable finding of the study was the increased safety of the biodegradable polymer BES, compared with the durable polymer SES, secondary to a significant reduction in very late (,1 year) ST and its associated clinical outcomes. A finding that continued out to 5 years, with the curves continuing to separate (Fig. 4). In addition, the incidence of ST associated with the biodegradable polymer BES appeared to have almost plateaued.. Despite the findings ...

New Age Garden ecoFLEX Living Wall Planter. Crafted from strong and durable ecoFLEX.. Made of recycled polymers and reclaimed wood fibers. Resistant to all any and all natural causes. Moisture-proof, wont dry rot, insect-resistant. Ideal for yards with limited space. Ideal for anyone with limited yard space or living in an apartment. The New Age Garden ecoConcepts Living Wall Planter allows you to grow up instead of out.. With several shelves for planting, this living wall provides almost 20-feet of growing space and can be mixed and matched with other living wall sizes and orientations (not included) to create a living work of art in your own backyard. Crafted from strong and durable ecoFLEX, which is comprised of recycled polymers and reclaimed wood fibers, this living wall is resistant to anything mother nature can throw at it. Moisture proof, this living wall will not warp, split, crack, dry rot, or be infested by insects. Its also non-toxic and naturally antimicrobial. Made mostly of ...

Thomas W. Federle, Ph.D., Research Fellow at Procter & Gamble, is the recipient of the 2015 INDA Lifetime Technical Achievement Award. His career involvement and commitment to bringing science-based approaches to issues in the nonwovens industry is a critical factor in earning him this award. Federle led research to modify existing aerobic and anaerobic biodegradation tests to assess flushable substrates and pioneered the early use of the shake flask to evaluate dispersibility of flushable products. These tests became part of the WERF Protocols to Assess the Breakdown of Flushable Consumer Products published in 2003 and formed the basis for development of the Flushability Assessment Test Guidelines, Editions 1, 2, and 3, and now under development, Edition 4. This market category has become one of the faster growing wipes categories, and Federles work has been instrumental in providing an effective means of measuring behavioral and disintegration properties for proper disposal of these ...

The Promus ELITE Stent System builds on the proven outcomes of almost 10,000 patients in 11 clinical trials of permanent polymer coronary stents

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Editors note: The best way to prevent liver cancer may be to avoid consumption of meat and dairy products, according to some earlier studies. Viral hepatitis and fungal toxins from grains are two major risk factors for liver cancer. However, if you do not eat meat and dairy products, liver damage by fungal toxins and hepatitis viruses can be reduced to minimal. Of course, its understandable that drinking mandarin orange juice or eating mandarin oranges helps prevent the deadly disease. ...

Object: The gold standard for reconstructing large nerve defects, the nerve autograft, results in donor-site morbidity. This detrimental consequence drives the search for alternatives. We used a vein filled with a small piece of fresh muscle to prevent the vein from collapsing and with bone marrow stromal cells (BMSCs) to enhance regeneration. Methods: In 60 rats, a 15-mm sciatic nerve defect was bridged with a nerve autograft, a vein filled with muscle or a vein filled with muscle and BMSCs. Toe spread and pinprick were used to evaluate motor and sensory function. Compound muscle action potentials (CMAPs) and the gastrocnemius muscle index (GMI) were recorded to assess conduction properties and denervation atrophy. Extensive histology was performed to confirm presence of BMSCs and to evaluate regeneration by staining neural tissue for Schwann cells and neural growth factor. Results: After 12 weeks, all animals responded with toe spread and pinprick reaction; significant differences were found ...

Right now, 8% of the worlds oil is used to make plastics - and oil has to be extracted from the belly of the earth using extremely energy and cost-intensive processes. At the same time, the worlds cities are constantly growing and producing more waste, which is usually dehydrated and trucked off to be dumped. In a planet-positive double-whammy, Micromidas has figured out how to transform raw sewage into a versatile form of plastic that biodegrades in 6-12 months. The new company (theyve only been around since mid-2008) accomplished the feat by harnessing microbes - specifically, bacteria - to produce a bioplastic resin, which can be processed into a malleable plastic ...

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Microbial Biopolyester Production, Performance and Processing: Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production ...

Because of this shifting production trend, European Bioplastics is calling European policy makers to do something about it and make biobased product markets as key priority in their industrial policy highlights.. In other recent bioplastic market reports, Transparency Market Research also released its new study stating that the global synthetic and bio-based biodegradable plastics market was worth $2.3bn in 2011 and is expected to reach $7.8bn in 2018, growing at an aggregate growth rate of 19.5% within the period.. Europe is said to continue leading the market in terms of revenue, and will account for 37% of the global market revenue share in 2018. Asia Pacific, meanwhile is expected to grow at 26% from 2011 to 2018 in terms of market share.. I guess this next study will dampen bioplastics good news as according to Germanys Federal Environment Agency (UBA), the overall ecological benefits of renewable-based biodegradable plastics used in packaging is no better than traditional petroleum-based ...

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Leeb, Christine ; Leitner, Rita ; Pichler, Verena ; Huber-Gries, Carina ; Rünzler, Dominik ; Jesenberger, Veronika (2016) Einführung und Optimierung eines praxisorientierten Problem-based-Learning-Moduls im Life-Science-Bereich ZFHE, Zeitschrift für Hochschulentwicklung, Jg.11 / Nr.3 (Mai 2016): S. 107-121. - https://www.zfhe.at/index.php/zfhe/article/view/897) Teuschl, Andreas Herbert ; Schuh, Christina Maria Anna Pia ; Halbweis, Robert ; Pajer, Krisztian ; Marton, Gabor ; Hopf, Rudolf ; Mosia, Shorena ; Rünzler, Dominik ; Redl, Heinz ; Nogradi, Antal ; Hausner, Thomas (2015) A new preparation method for anisotropic silk fibroin nerve guidance conduits and its evaluation in vitro and in a rat sciatic nerve defect model Tissue Engineering Part C: Methods / 2015 / vol. 21 / no. 9 / p. 150328090920000 / ISSN 1937-3384 / DOI 10.1089/ten.TEC.2014.0606. Heher, Philipp ; Maleiner, Babette ; Prüller, Johanna ; Teuschl, Andreas Herbert ; Kollmitzer, Josef ; Monforte, Xavier ; Wolbank, Susanne ; ...

October 30, 2016 -- Dublin and Washington -- Investigators today unveiled clinical data from the independent BIO-RESORT study, representing the first all-comers analysis to compare the safety and efficacy of biodegradable polymer stents (BP-DES) to durable polymer Resolute™ Integrity™ drug-eluting stent (DP-DES) from Medtronic plc (NYSE: MDT). At one year, patients with coronary artery disease who were treated with a biodegradable polymer stent showed no clinical benefits over patients treated with Resolute Integrity. The highly-anticipated results were presented today during a Late-Breaking Clinical Trial session at the Transcatheter Cardiovascular Therapeutics (TCT) Annual Meeting and simultaneously published in The Lancet. As authors write in The Lancet manuscript, Neither of these [biodegradable] stents have [previously] been compared with the new-generation thin-strut durable polymer zotarolimus-eluting stent (Resolute Integrity, Medtronic, Santa Rosa, CA, USA) - an established device ...

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The Office of Programs for Alcohol and Drug Problems is the designated Single State Authority for the planning and development of alcohol and drug programs. It is within the State Mental Health Division, and is the interface between the Division, the counties, and the federal government with regard to alcohol and drug programs. The Divisions Office of Management Support Services (MSS) is charged with the responsibility of developing an evaluation system for programs. This is being done in regard to the needs of programs and decision-makers concerned with programs. The Program Office is now providing input to MSS largely through this practicum paper, and through the involvement of the author with staff of MSS and the Divisions Task Force on Evaluation Systems. The goal of the practicum, and the involvement with MSS, which will continue, is to assist in the development of an evaluation system that will enable the Program Office to better perform the tasks of assessing programs, and planning for this

For dessert, I had the Mandarin Orange Frozen Timbale with Thai Basil - Raisin Jam, Deep-Fried Praline and Rose Syrup. To be honest, I was a bit hesitant to have this as Im not a fan of raisins and rose-flavored items. I was afraid that this one might just ruin the delicious flavor on my taste buds. However, as they say, a true foodie is not afraid to try new flavors and so after taking a deep breath, I took the plunge and was surprised that I actually liked it! The frozen timbale topped with mandarin orange was light and juicy. It was actually perfect to remove all savory notes on your taste buds and cleanse it with the sweet mandarin orange and cream. The praline was also very good too and definitely no yucky, overpowering taste from the raisins or rose. Yay ...

The management of fishery residues and plastics is considered to be a vital strategy for conserving resources and maintaining the quality of the environment. Poly(l-lactic acid) (PLA) is a commercially promising, renewable, and biodegradable plastic. In this study, a PLA depolymerase was produced in a squid pen powder (SPP) and recycled plastic waste (PLA powder)-containing medium by Pseudomonas tamsuii TKU015, a bacterial strain isolated from Taiwanese soil. This PLA depolymerase had a molecular weight of 58 kDa and was purified to homogeneity from the supernatant of a TKU015 culture. The optimum pH of TKU015 PLA depolymerase is 10, and the optimal temperature of the enzyme is 60 °C. In addition to PLA, TKU015 PLA depolymerase degraded fibrinogen and tributyrin, but did not hydrolyze casein, triolein, and poly(β-hydroxybutyrate). Taken together, these data demonstrate that P. tamsuii TKU015 produces a PLA depolymerase to utilize SPP and polylactide as carbon/nitrogen sources.

Articles manufactured with a composition comprising a polymer of an unsaturated hydrocarbon, a C1-4 alkyl or hydroxyalkylether of starch having a degree of substitution of at least 0.25, and a polyhydric aliphatic alcohol having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups; wherein the compatibilizing agent can be a vinyl copolymer, acrylic copolymer and mixtures thereof. The composition can be used in the preparation of biodegradable plastics.

A student from Englands University of Sussex has won about $40,000 for the invention of a translucent and biodegradable plastic made entirely from fish leftovers. Lucy Hughes hopes the grant from the James Dyson Award will help jumpstart her MarinaTex into large-scale production. Matthew Larotonda reports.

This will knock you out. Im sending you something Ive just found called Leaves.â„¢ Its a new product from Past Toyz in Shanghai featuring a giant biodegradable plastic bag containing real farm grown leaves that have been hygienically dried and treated with an anti-bacterial agent for safe outdoor fun â„¢ Can you believe it? Why didnt we think of that? I think the idea is that you empty the bag in your backyard and play with the leaves. Either that or you can drive that hygiene and order fixated neighbor or yours crazy by placing a single leaf on his plastic lawn every night for the next two years. I suppose the company did some research with Maverns and Connectors that said that people in urban areas arent getting as close to nature as they like. Back in my day leaves grew on trees but the colours werent manipulated and the bugs were kept in check by other bugs not chemicals. Anyway, it certainly made me laugh. You can always send it back if the joke is lost on you ...

A research team has developed a new process that utilizes meat and bone meal (MBM) as raw materials to produce partly biodegradable plastic.

Made from Australian approved food grade standard PLA which us a biodegradable plastic derived from renewable resources. Product should be hand washed only in warm soapy water and never in a dishwasher. Cutter and stamps should be kept away from heat ...

Biorefining allows manufacturers to create sustainable, renewable, high-value end products from biomass. The end products have applications in gasoline, diesel and jet engine fuel, specialty chemicals, chemical intermediates, biodegradable plastics, pharmaceuticals, and other consumer products.

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Local Darwin weather has been relatively quiet since the project was completed in November 2006, with the rain in the period up to late February relatively low, by local standards, and no major storm events. But, over the period March 1, 2007 through 6 March, that changed - with over 500 mm in this period with about 90% falling in the three days 3-5 March. The area flooded, with around 300mm across the road, although relatively slow moving, and the road was closed, except for large 4WD and trucks on Saturday and Sunday. ...