The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods.

The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods.

Biomaterials †Khademhosseini Laboratory. The Journal mainly promotes the novel emerging Biomaterial applications to Medical Sciences like Biomaterials, Tissue Engineering Biomaterials Applications,, Buy Biomaterials for Tissue Engineering Applications from Dymocks online BookStore. Find latest reader reviews and much more at Dymocks. Biomaterials and Tissue Engineering MSc UCL Mechanical Engineering. Application and next steps. Applications. Students are advised Application fee: Biomaterials and scaffolds for tissue engineering OBrien F. Biomaterials and scaffolds for tissue the art of scaffolds for tissue engineering applications.. With advancements in biological and engineering sciences, the definition of an ideal biomaterial has evolved over the past 50 years from a substance that is inert to Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications Chengdong Jia, Ali Khademhosseinib,c,d, Fariba Dehghania,*. Interdisciplinary research into ...

Wearable medical devices such as continuous heart rate monitors, insulin pumps, and neural stimulators usually need access to an electric power source in order to function. While theres a great deal of wasted energy that our body emits that can be harvested to power such devices, making it actually happen using biocompatible materials has proven to be challenging. Now, a team of engineers at Purdue University has shown that polyvinyl alcohol (PVA), one of the most common polymers used in biomedicine, can be used to produce efficient triboelectric nanogenerators (TENGs) that can also act as cardiac activity monitors.. The PVA-based TENGs show great potential for self-powered biomedical devices and open doors to new technologies that use widely deployed biocompatible materials for economically feasible and ecologically friendly production of functional devices in energy, electronics and sensor applications, said Wenzhuo Wu, the leader of the research team. We transform PVA, one of the most ...

Biomaterials are further evolving. Biomaterials for hearing implants depend on components, structural polymers, and electrodes. Biomaterials have transformed the medical treatment of hearing loss. The ear dysfunction, hearing loss is able to be addressed and repaired via a device implant that leverages biomaterials. Alloplastic and homograft biomaterials have been used to restore hearing with ossicular replacement prostheses, cochlear implants, and implantable middle ear devices. Biomaterials are used in implantable middle ear devices and inner ear implants. Biomaterials for middle ear applications of implantable devices are significant. The site of implantation and the mass of the implant dictate the choice of biomaterials. Hermetic sealing of an implant is best achieved by the use of metals, not polymers. The Osteocompatibility of an ossicular implant can be enhanced by the incorporation of calcium phosphates such as hydroxyapatite coatings. The market research study provides insight into market

Mechanical performance and biocompatibility study of methacrylated Gellan gum hydrogels with potential for nucleus pulposus regeneration ...

This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and

Polyimide (PI) is a commonly used polymer in microelectronics. Recently, numerous PI-based flexible neural interfaces have been developed for reducing mechanical mismatch between rigid implant and soft neural tissue. Most approaches employ non-photosensitive PI, which has been proven earlier to be biocompatible. However, photosensitive polyimide (PSPI) would simplify device fabrication remarkably, but its biocompatibility has been only sparsely reported. In this study, cytotoxicity of spin-coated PSPI (HD Microsystems PI-2771) and conventional PI (HD Microsystems PI-2525) films were evaluated in vitro using BHK-21 fibroblasts according to the ISO-10993-5 standard. PSPIs were tested as cured at a temperature of 200 degrees C (PI-2771-200) and 350 degrees C (PI-2771-350). The PI film surfaces were characterized in terms of their roughness, energy and zeta potential which are hypothesized to affect cell-material interactions. The values of the total surface free energy (SFE), and its polar and ...

The term bioprinting refers to processes that bring biological materials such as cells, biomolecules and tissue preparations or biocompatible materials into a three-dimensional structure in order to fulfil a biological function.. While the Fraunhofer Institutes ILT, IFAM and IPA are working on the generative construction of improved orthopaedic implants and orthoses made of metal powders and synthetic materials, Fraunhofer IGB develops so-called biotools from biocompatible polymers, biological molecules from the natural tissue matrix and cells for the reconstruction of biological tissues.. In the future, natural, human tissue models should enable meaningful and individual diagnostic and pharmacological tests, avoid animal experiments and eventually also be available as implantable biological tissue sets. ...

F3088-14 Standard Test Method for Use of a Centrifugation Method to Quantify/Study Cell-Material Adhesive Interactions cell adhesion~ cell-to-material interaction~

TY - CONF. T1 - Nanodiamond-dotma Complexes As Effective Non-viral Vectors For Gene Therapy. AU - Paredes, Alejandro. AU - AL Qtaish Hasan, Nuseibah AU - Sainz-Ramos, Myriam AU - Lopez-Mendez, Tania AU - Villate-Beitia, Ilia. AU - Gallego, Idoia AU - Puras, Gustavo AU - Pedraz, Jose Luis. PY - 2020/7. Y1 - 2020/7. N2 - Introduction: Gene therapies are rapidly becoming a critical component of the therapeutic armamentaria for a variety of inherited and acquired human diseases (1). Nevertheless, the development of safer and more efficient vectors for gene delivery remains an area of great potential for improvement. Nanodiamonds (ND) are a highly biocompatible material with unique physicochemical features that make them an attractive platform for the development of novel non-viral vectors (2). In this work, we describe for the first time the combination of a cationic lipid (DOTMA) and ND to gene delivery purposes.Methods: ND-DOTMA vectors were obtained by an o/w emulsification method. The oil phase, ...

TY - JOUR. T1 - Monocyclic β-lactams loaded on hydroxyapatite: new biomaterials with enhanced antibacterial activity against resistant strains.. AU - Giacomini, Daria. AU - Torricelli, Paola. AU - Gentilomi, G.. AU - Boanini, Elisa. AU - Gazzano, Massimo. AU - Bonvicini, F.. AU - Benetti, E. AU - Soldati, R. AU - Martelli, Giulia. AU - Rubini, K.. AU - Bigi, A.. PY - 2017/6/2. Y1 - 2017/6/2. N2 - The development of biomaterials able to act against a wide range of bacteria, including antibiotic resistant bacteria, is of great importance since bacterial colonization is one of the main causes of implant failure. In this work, we explored the possibility to functionalize hydroxyapatite (HA) nanocrystals with some monocyclic N-thio-substituted β-lactams. To this aim, a series of non-polar azetidinones have been synthesized and characterized. The amount of azetidinones loaded on HA could be properly controlled on changing the polarity of the loading solution and it can reach values up to 17 wt%. ...

A multi-density polymeric interbody spacer formed from biocompatible material for osteoconductivity includes multiple density regions of different porosity to provide both strength and osteoconductivity. An interface region is formed between the density regions to provide both direct adhesion and mechanical interlocking between the different density regions to increase the strength of the multi-density polymeric interbody spacer. A method for forming the multi-density polymeric interbody spacer includes curing a first density region to achieve a first target porosity. A second density region may then be molded to the first density region to achieve a second target porosity. A portion of the second density region partially flows into pores of the first density region, providing direct adhesion and mechanical interlocking between the first and second density regions.

Indigo Microfiber Applicator - Indigo microfiber takes on a new shape! The Indigo Microfiber Applicator is made of the same outstanding microfiber as the Indigo Edgeless Microfiber Polishing Cloth. This 70/30 microfiber is woven from threads ...

In recent years, the development and application of decellularized extracellular matrices (ECMs) for use as biomaterials have grown rapidly. These cell-derived matrices (CDMs) represent highly bioactive and biocompatible materials consisting of a complex assembly of biomolecules. Even though CDMs mimic the natural microenvironment of cells in vivo very closely, they still lack specifically addressable functional groups, which are often required to tailor a biomaterial functionality by bioconjugation. To overcome this limitation, metabolic glycoengineering has emerged as a powerful tool to equip CDMs with chemical groups such as azides. These small chemical handles are known for their ability to undergo bioorthogonal click reactions, which represent a desirable reaction type for bioconjugation. However, ECM insolubility makes its processing very challenging. In this contribution, we isolated both the unmodified ECM and azide-modified clickECM by osmotic lysis. In a first step, these matrices were ...

The hereditary hemophilias are the most common inherited severe bleeding disorders and are characterized by lifelong bleeding, both spontaneous, internal bleeding as well external bleeding due to injury, most commonly from surgical procedures. The current research grant proposes to develop a new biocompatible matrix employing nanotechnology that is hemostatic by incorporating a peptide that accelerates blood coagulation and will therefore stop bleeding. This peptide was discovered in my laboratory and reduces bleeding in animal models of hemorrhage. Therefore, attaching this peptide to „nanotechnology‟ based materials has great promise as a novel agent to reduce bleeding from external hemorrhagic injuries. The methodology will include utilizing standard biochemical techniques to characterize the material followed by the testing of the biocompatible material in animal models. The development of this product is especially relevant to the goals of the Canadian Hemophilia Society by discovering ...

Jorge Almodovar. Jorge Almodóvar earned his B.S. in Chemical Engineering from Iowa State University in 2007. He then enrolled in Colorado State University where he earned his Ph.D. in Chemical Engineering in 2011. At CSU he investigated the delivery and stability of growth factors using polysaccharide-based biomaterials. After CSU, he worked as a Post-Doctoral Fellow at the Grenoble Institute of Technology in Grenoble, France investigating the formation of gradients on polyelectrolyte multilayer films, funded by the Whitaker International Program. Currently he is an assistant professor in the Chemical Engineering Department at the University of Puerto Rico-Mayagüez. His research interests include extracellular matrix mimetic biomaterials, cell-material interactions, and growth factor delivery. His research focus is on the engineering of biomimetic materials-inspired by the native cell environment-for fundamental studies, therapeutics, and regenerative medicine.. ...

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

Lawrence Stanton joined the Genome Institute of Singapore in 2002, where he serves as an Associate Director. He holds Adjunct Professorships at the Department of Biological Sciences, National University of Singapore, and School of Biological Sciences, Nanyang Technological University. His current research is focused on the molecular characterization of transcriptional regulatory networks in stem cells and disease-specific iPSC cells with the aim to direct the growth, differentiation, and reprogramming of these cells into therapeutically useful tissues and models of human diseases. Recently, the lab has been generating induced pluripotent stem cells (iPSC) from patients with neurological disorders. These patient-specific iPSC are then converted into various neural cell types, which provides us the opportunity to study diseased neural tissue in vitro. By generating micro-tissues of neural origin by bioengineering multiple cell types in 3-D on biocompatible materials his group is collaborating ...

0056]In some embodiments, tissue contacting members 102 are coupled with support member 104. Support member 104 may be made of any suitable biocompatible material, such as titanium, stainless steel, nickel titanium alloy (Nitinol) or the like. Support member 104 may be coupled with tissue contacting members 102 by any suitable means, such as but not limited to one or more adhesive substances, placement of a portion of support member 104 within a sleeve on tissue contacting members 102 or a combination of both. Like tissue contacting members 102, support member 104 may also be malleable or deformable to allow for insertion of ablation device 100 through a minimally invasive sheath 124 and/or for enhancing conformability of device 100 to a surface of heart 140. Support member 104 typically includes at least one support arm 106 or similar protrusion or multiple protrusions for removably coupling ablation device 100 with positioner 114 or one or more other positioning devices. Positioner 114, for ...

Heterostructures of wide bandgap semiconductors such as silicon carbide (SiC) or group-III nitrides are attracting increasing interest for applications in the field of chemical and biological sensing. These biocompatible materials are particularly promising due to the possibility of bandgap engineering using the different SiC polytypes or AlxGa1-xN alloys, which could allow to optimize the charge transfer between the semiconductor device and the functional layer. A basic requirement for semiconductor biosensors based on organic-semiconductor hybrid structures is the direct covalent attachment of functional organic layers to the semiconductor surface. In my Ph.D. thesis, I systematically study different routes to obtain such functional layers on SiC and AlGaN alloys, including the silanization and hydrosilylation processes ...

Free Online Courses In Biomedical Engineering Kelsey DeFrates is a rising senior at Rowan University in the biomedical engineering program and dreams of creating biocompatible materials to regenerate lost or damaged tissues or develop biosensors. She was awarded the. Stanfords Introduction to Robotics (CS223A) - and other popular computer science and engineering courses - are now available free online. The robotics. Interested residents must submit an application, which is available in print and.. Besides offering a community service for parents of toddlers, the preschool has been a training ground for Penn-Trafford students who are interested in becoming teachers. Students work with the toddlers in two semester-long classes and.. Helpful online courses and information for the physical education teacher who wants to continue to develop and grow! View all 79 Resources!. Bicycle Repair Online Classes A technical training school offering information and classes in bicycle mechanics, ...

Proplast: Polymer of polytetrafluoroethylene and carbon filaments; porous biocompatible material used in orofacial and middle ear reconstruction and as coating for metal implants.

A lattice for the fixation of bone parts or for the bridging of bone defects, particularly in the region of the skull and jaw, is made of biocompatible material with a reticular structure and with recesses for receiving bone screws, with which the lattice can be secured on the bone. The lattice does not have circular rings for receiving bone screws, but instead each lattice recess (32) can be used for receiving a bone screw. The bridges form meandering, continuous, regular bridge rows along the main axes of the lattice.

Endodontic treatment can often be performed in one or two visits and involves the following steps:. The dentist examines and x-rays the tooth, then administers local anaesthetic. After the tooth is numb, the dentist places a small protective sheet called a dental dam over the area to isolate the tooth and keep it clean and free of saliva during the procedure.. The dentist makes an opening in the crown of the tooth. Very small instruments are used to clean the pulp from the pulp chamber and root canals and to shape the space for filling.. After the space is cleaned and shaped, the dentist fills the root canals with a biocompatible material, usually a rubber-like material called gutta-percha. The gutta-percha is placed with an adhesive cement to ensure complete sealing of the root canals. In most cases, a temporary filling is placed to close the opening. The temporary filling will be removed by your dentist before the tooth is restored.. After the final visit with your dentist, you must return ...

The sooner you get treated for tooth decay, the less likely youll lose your tooth. That could mean a simple filling-or you might need a root canal treatment if decay has reached the inner pulp.. Theres also another procedure for advanced decay called pulp capping. Its a bit more involved than filling a cavity but less so than a root canal. We can use it if decay has exposed or nearly exposed the pulp, but not yet infected it-otherwise, you may still need a root canal treatment to remove the diseased pulp tissue.. There are two types of pulp capping methods, direct and indirect. We use direct pulp capping if the pulp has been exposed by decay. After isolating the tooth to protect other teeth from contamination, we remove all of the decayed dentin up to the pulp. This may cause some bleeding, which well stop, and then clean and dry the tooth area.. Well then apply a protective biocompatible material directly over the pulp to promote healing and protect it from further infection. We then ...

Radiesse (Bioform Inc, USA) is a sterile, latex-free, non-pyrogenic, semi-solid, cohesive subdermal, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. T

Aging Analytical philosophy Anthropology ATP Biocompatible materials Biological age Cell types Death DNA External causes of death Extracellular Matrix (ECM) Gene Gene therapy Genetic engineering Genomics Growth factor Human rights Internal causes of death In vitro In vivo Life extension: soft, radical, maximum Metabolism Mitochondrion Moral person Nanotechnology Nucleic acids Omics Organ Partial immortalization Pimm…

Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...

High reliability electrical connections between a helical strand and flat electrodes, such as strip electrodes found in implantable neurostimulator systems, are described. The connection consists of a crimp joint in which an inside diameter mandrel is used to provided the coil with sufficient radial rigidity to ensure structural integrity of the crimp. The mandrel is made of a relatively soft biocompatible material that deforms rather than damages the fine wires of the helical strand during crimping. The crimp is accomplished by radial deformation of an annular or semi-annular crimping member that receives the helical strand/mandrel assembly.

The penile implant of the present invention comprises a ring of soft biocompatible material which is adapted to be implanted beneath the skin of the penis of an incontinent male. The ring when implanted produces a protuberance which effectively increases the diameter of the penis so as to retain the flexible elastic sheath of a urinary collection device in place. A relatively stiff rod also may be implanted in the penis beneath the ring to support the ring. The protuberance produced by the implanted ring permits the patient to securely attach and easily remove the flexible sheath of the urinary collection device without the assistance of others.

Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...

Devices are disclosed for occluding defects in an annulus fibrosis to prevent conditions such as disc herniation and recurrent disc herniation. The preferred embodiments comprise an intradiscal component having a width greater than the width of the defect and a height less than the intervertebral spacing, and an extradiscal component physically coupled to the intradiscal component, the extradiscal component having a height greater than the intervertebral spacing. The components most preferably each comprise two outwardly extending arms, of equal or unequal length, oriented transversely with respect to one another. The arms of the extradiscal component are preferably of sufficient length to overlap at least a respective portion of the adjacent vertebrae. The invention further anticipates a body disposed between the intradiscal and extradiscal components to at least partially consume the defect. The body is composed of a natural or synthetic biocompatible material, such as a resilient or compressible

Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...

Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...

An intraocular lens injector cartridge having a heat retention additive for helping the cartridge retain heat once the cartridge is warmed. Such additives can include an biocompatible material having high heat retention, for example, powdered gold.

0058]Although the casing 72, sleeve 74, initial fenestration burr 150 and fenestration polishing burrs 180 are described herein in terms of their presently preferred embodiments, it is to be understood that such disclosure is purely illustrative and is not to be interpreted as limiting. Thus, for example while the casing 72 is described as preferably being made from titanium, it may be fabricated from any biocompatible material which exhibits suitable characteristics that permit the prongs 92, 102 to engage the otic capsule bone 34 surrounding the fenestration 36 to lock the casing 72 therein. Similarly, while the casing 72 has been described as being assembled by welding the collar 76 to the sleeve 74, it may also be machined from a single piece of material. Correspondingly, more or fewer than three slits 82 may pierce the sleeve 74 in orientations other than equally spaced, and more or fewer than six (6) prongs 92, 102 may be formed on the sleeve 74 jutting outward therefrom in locations other ...

US Pharm. 2015;40(7):26.. Chapel Hill, NC-An invention by scientists at the University of North Carolina and North Carolina State might take the sting out of diabetes injections: a smart patch that detects increases in blood sugar levels and automatically secretes insulin doses into the bloodstream. No larger than a penny, the patch is covered with more than 100 small needles housing microscopic insulin and glucose-sensing enzyme storage units. In a study published in the Proceedings of the National Academy of Sciences, the patch lowered blood glucose in a mouse for 9 hours. Before the patch can be used in humans, clinical trials are needed. Said co-senior study author Zhen Gu, PhD, the patch works fast, is easy to use, and is made from nontoxic, biocompatible materials.. To comment on this article, contact [email protected].. ...

Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of clinically suitable formulations of hybrid manganese dioxide (MnO2) nanoparticles (MDNP) using biocompatible materials to reoxygenate the TME by reacting with endogenous H2O2. MDNP containing hydrophilic terpolymer-protein-MnO2 or hydrophobic polymer-lipid-MnO2 provided different oxygen generation rates in the TME relevant to different clinical settings. In highly hypoxic murine or human xenograft breast tumor models, we found that administering either MDNP formulation before radiotherapy modulated tumor hypoxia and increased radiotherapy efficacy, acting to reduce tumor growth, VEGF expression, and vascular density. MDNP treatment also increased apoptosis and DNA double strand breaks, increasing median host survival 3- to 5-fold. Notably, in the murine model, approximately 40% of tumor-bearing mice were tumor-free ...

There is a strong need of new materials to address current limitations in wound healing and in the translational aspects of wound healing. Progress in this area is limited by the void of information at the molecular level addressing cell-material interactions, at the tissue level addressing the evolution of implantable scaffolds and at the organ level addressing the development of new intervention methods to enhance healing. This thrust aims to create novel materials and experimental techniques to overcome these challenges. By tackling the steps between materials development and implantation, it is generating design rules and predictive models to determine the viability of a material in enhancing wound healing. Thrust Members:. ...

Theres a lot of interest in soft materials, particularly biomaterials, explains Guenther of the materials that help create functional tissue cultures, but until now no one has demonstrated a simple and scalable one-step process to go from microns to centimeters. How exactly does a machine grow a large patch of living tissue?. Scientists manipulate biomaterials into the micro-device through several channels. The biomaterials are then mixed, causing a chemical reaction that forms a mosaic hydrogel-a sheet-like substance compatible with the growth of cells into living tissues, into which different types of cells can be seeded in very precise and controlled placements.. Unique to this new approach to tissue engineering, however, and unlike more typical methods for tissue engineering (for instance, scaffolding, the seeding of cells onto an artificial structure capable of supporting three-dimensional tissue formation) cells planted onto the mosaic hydrogel sheets are precisely incorporated into ...

Cadee JA, Brouwer LA, den OW, Hennink WE, and van Luyn MJ. (2001). A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats. J Biomed Mater Res 56: 600-9. PubMed. De Groot CJ, van Luyn MJ, Van Dijk-Wolthuis WN, Cadee JA, Plantinga JA, den OW, and Hennink WE. (2001). In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts. Biomaterials 22: 1197-203. PubMed. Geertsema AA, Schutte HK, Rakhorst G, van Luyn MJ, Mahieu HF, and Verkerke GJ. (2001). A novel tracheal tissue connector for fixation of laryngeal prostheses. Biomaterials 22: 1571-8. PubMed. Greijer AE, Verschuuren EA, Harmsen MC, Dekkers CA, Adriaanse HM, The TH, and Middeldorp JM. (2001). Direct quantification of human cytomegalovirus immediate-early and late mRNA levels in blood of lung transplant recipients by competitive nucleic acid sequence-based amplification. J Clin Microbiol 39: 251-9. ...

Dr. Guvendirens research focuses on designing novel polymeric biomaterials for tissue engineering applications and regenerative medicine. In particular, he is interested in spatiotemporal control of hydrogel properties, cell-biomaterial interactions, 3D bioprinting, biofabrication, surface pattering and photopolymerization. Applications of his research include regeneration of bone, cartilage and osteochondral interface as well as engineered in vitro disease models. Prior to joining NJIT, Dr. Guvendiren was an Assistant Research Professor at Rutgers University, at the New Jersey Center for Biomaterials. Dr. Guvendiren did a postdoc in Bioengineering and Materials Science and Engineering Departments at the University of Pennsylvania. He received his Ph.D. in Materials Science and Engineering at Northwestern University. ...

In 2010 I received my Bachelor in Biotechnology and in 2012 my Master degree in Biomedical Biotechnology from Universitat Politecnica de Valencia in Spain. Between 2012 and 2017 I pursued a PhD in Biomedical Biotechnology at the Universitat Politecnica de Valencia, obtained with European mention and honors. During my PhD my research activity was complemented by several internships, at the Centre for Cell Engineering at the University of Glasgow, 2012; a Marie-Curie-IAPP Program Secodment in Germany, 2013; and The Biomaterial Immuno-Engineering Lab at the University of Florida, 2014. I worked on investigating the role of fibronectin and growth factors on mediating cell-material interactions towards bone differentiation.. In 2017, I started as a Research Assistant in Professor Matthew Dalby reseach group where I have been working on growth factors and material-based strategies to engineer tissue repair and regeneration and with my own side project in 2019 on the discovery of metabolites involved ...

We report a highly biocompatible and practical protocol to create alginate microgels for bioactive encapsulation. Double-emulsion drops composed of dual cores enclosed by an ultrathin shell are prepared in a capillary microfluidic device, which exhibit selective coalescence between the cores. When the cores are laden with alginate precursors and divalent ions, respectively, coalescence leads to the formation of alginate microgels in the fused core of double-emulsion drops. The microgel can be rapidly released into a continuous water phase by rupturing the liquid shell. This method neither involves any toxic chemical cues for gelation nor long-term exposure to oil, thereby providing highly biocompatible encapsulation. ...

This report studies the global biomaterial market over the forecast period of 2012-2017. The global market for biomaterials is estimated at $44.0 billion in 2012 and is poised to grow at a CAGR of 15% from 2012 to 2017 to reach $88.4 billion by 2017.. The global biomaterial market is broadly segmented into two categories, by type and by application. The global biomaterial market, by type, is broadly categorized into metals, ceramics, polymers, and natural biomaterials. The biomaterial applications market is broadly segmented into orthopedic, cardiovascular, neurological, dental, tissue engineering, wound healing, plastic surgery, ophthalmology and other applications such as gastrointestinal, urinary, bariatric surgery, and drug delivery system. In 2012, the cardiovascular biomaterial segment contributed 34.5% to the global biomaterial market, followed by the orthopedic segment. Plastic surgery and wound healing applications are expected to witness the highest growth in the coming ...

In addition to a material being certified as biocompatible, it is important that biomaterials are engineered specifically to their target application within a medical device. This is especially important in terms of mechanical properties which govern the way that a given biomaterial behaves. One of the most relevant material parameters is the Youngs Modulus, E, which describes a materials elastic response to stresses. The Youngs Moduli of the tissue and the device that is being coupled to it must closely match for optimal compatibility between device and body, whether the device is implanted or mounted externally. Matching the elastic modulus makes it possible to limit movement and delamination at the biointerface between implant and tissue as well as avoiding stress concentration that can lead to mechanical failure. Other important properties are the tensile and compressive strengths which quantify the maximum stresses a material can withstand before breaking and may be used to set stress ...

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Admira® Flow is highly biocompatible flowable ormocer composite in unit dose caps or syringes used for Repair of fillings, veneers and temporary crowns and bridge. Admira® Flow can also be utilized for luting of translucent prosthetic pieces ...

TY - JOUR. T1 - Synthesis, mechanical properties, and in vitro biocompatibility with osteoblasts of calcium silicate-reduced graphene oxide composites. AU - Mehrali, Mehdi. AU - Moghaddam, Ehsan. AU - Shirazi, Seyed Farid Seyed. AU - Baradaran, Saeid. AU - Mehrali, Mohammad. AU - Latibari, Sara Tahan. AU - Metselaar, Hendrik Simon Cornelis. AU - Kadri, Nahrizul Adib. AU - Zandi, Keivan. AU - Osman, Noor Azuan Abu. PY - 2014/3/26. Y1 - 2014/3/26. N2 - Calcium silicate (CaSiO3, CS) ceramics are promising bioactive materials for bone tissue engineering, particularly for bone repair. However, the low toughness of CS limits its application in load-bearing conditions. Recent findings indicating the promising biocompatibility of graphene imply that graphene can be used as an additive to improve the mechanical properties of composites. Here, we report a simple method for the synthesis of calcium silicate/reduced graphene oxide (CS/rGO) composites using a hydrothermal approach followed by hot isostatic ...

Vitiligo is a chronic disease that causes loss of melanocyte and pigment of the skin. Traditional treatments for vitiligo including topical corticosteroids and phototherapy lead to limited clinical effects. Autologous melanocyte transplantation is another way to treat vitiligo. However, the effect is largely affected by whether cultivated melanocytes are successfully uptaken by vitiliginous skin. The aim of this study is to survey the self-assembly on biomaterials and functional analysis. In the long run, this study may provide a better way for treatment of vitiligo ...

Biofabrication and biomaterials for urinary tract reconstruction Moustafa M Elsawy,1-3 Achala de Mel1 1Division of Surgery and Interventional Science, Royal Free Hospital, NHS Trust, University College London (UCL), 2Division of Reconstructive Urology, University College London Hospitals (uclh), London, UK Abstract: Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patients autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials.

The thermal degradation behavior of indium tin oxide (ITO) thin films coated on glass substrates using radio frequency (rf) magnetron sputtering was invest

A biodegradable polymer with surface properties that promotes cell attachment and host integration is widely recognized as a useful three-dimensional construct for bone tissue engineering applications. In this work, studies were carried out to correlate surface properties of modified polycaprolactone (PCL) films with cell-material interactions. PCL film substrates were subjected to various degrees of chemical hydrolysis using different pretreatment solutions to introduce different densities of carboxylate groups onto the surfaces. The extent of hydrolysis on the films was optimized to allow the deposition of a dense and uniform bone-like apatite layer by an alternate soak treatment, followed by subsequent incubation in simulated body fluid (SBF). The hydrolyzed and apatite-coated PCL films were investigated using scanning electron microscopy, thin film X-ray diffractometer (TF-XRD), water contact angle, and Alizarin red staining. Surface wettability, roughness, and chemistry of various PCL ...

Large-scaled composite hydrogels (several. centimeters) have been prepared for use in biomedical applications such as cartilage and bone. However, few preparation methods of nanocomposites of PVA and Hap have been reported. In this study, the nano-, microparticles of PVA, HAp and DNA were obtained by using high hydrostatic pressure technology. It is thought that this is achieved by the pressure-induced Inhibitors,research,lifescience,medical quick formation of PVA particles that could incorporate secondary and third substrates, such as DNA and HAp, without phase separation [15, 31]. 3.2. Cytotoxicity Test Figure 4 shows the result of the cytotoxicity test of PVA/DNA and PVA/HAp/DNA complexes. Inhibitors,research,lifescience,medical The high viability of COS-7 cells incubated with them is shown, irrespective of the concentration of PVA and HAp. PVA and HAp are biocompatible materials [32, 33]. The PVA/DNA complex is nontoxic. because of the composite formation of PVA and DNA via hydrogen bonding ...

Find Experts in contact lenses for media, speaking, business opportunities, expert witness and more. Get insights into other topics affecting contact lenses with expertise from Myopia Experts, Optometry Experts, Biocompatible Materials Experts, Biodegradable Materials Experts, Biomolecular Engineering Experts

This review detailed the most commonly used biomaterial scaffolds for engineering tissues from stem cells by covering the types of materials available and their unique properties. This information allows readers to determine which material best suits their specific application. As mentioned in earlier in this review, many of these materials have not been fully optimized for specific tissue engineering applications and further work will continue to optimize these formulations for translation to the clinic for targeted applications. For example, optimized scaffolds could enhance the survival and differentiation of neural stem cells being transplanted into the diseased or damaged nervous system, which could lead to improved function. The type of material and the cues that are incorporated in the scaffold play a large role in directing the fate of the stem cells seeded inside as detailed in this review. The ability to further functionalize the materials discussed in this review in terms of their ...

Title: Modeling the fatigue behavior of thermomechanical shape memory alloys: Application to the optimization of biocompatible actuators for cardiac implants.. Subject: The aim of this project is the development of a thermomechanical modeling tool, robust and able to capture the different inelastic mechanisms that occur under cyclic loading in shape memory alloys (phase transformation, martensitic reorientation, plasticity, damage). This tool will be implemented in the finite element program ABAQUS in order to predict the fatigue of actuators for biomedical engineering applications. The developed model will be operated for the prediction and optimization of the fatigue strength of an innovative cardiac assist actuator equipped with SMA biocompatible material (NiTi and TiNb) under non-isothermal, cyclic and multiaxial, non-proportional loading conditions. The cardiac implant is a lamellar system consisting of a superelastic SMA and it has been designed in collaboration with the Nancy School of ...

Expandable devices and methods for treating and enlarging a tissue, an organ or a cavity. The device is composed of a hollow expanding pouch made of a resorbable material or a perforated material that can be attached to a filling element. The pouch can be filled with a biocompatible materials, one or more times in few days interval, after the insertion of the device. While filling the pouch every few days the tissue expands and the filling material if it is bioactive start to function. The devices allow immediate direct contact between the filling material and the tissue. These devices and methods can be used for example for: horizontal and vertical bone augmentation in the jaws, soft tissue augmentation, fixating bone fractures etc.

Dr. Paige Woods and her team at Brighton Dental in San Diego believe only high-quality, durable, biocompatible materials should be used for any kind of medical application. The mouth is the portal to the body, making biocompatible dentistry especially important.. Patients who have had silver fillings in their mouth often wonder what the importance of replacing their silver fillings really is. Truth is, amalgam contains an element known as mercury, which is very toxic to humans. It is believed that amalgam fillings release trace amounts of mercury vapor during chewing, which are then inhaled or absorbed into the body leading to issues over time.. There is much controversy looking around the issue of whether or not amalgam fillings belong in the mouth, but no matter whose side you are on we know one thing to be true: its better to be safe than sorry.. Main reasons people have their silver, amalgam fillings replaced:. ...

BioBots is a recent graduate of DreamIt Health Phillys 2014 accelerator. I spoke with Cabrera, the CEO.. Q: How did you come up with the idea for the biz?. A: There are devices that can build 3-D structures out of human tissue, but theyre big, expensive and difficult to use. So Ricardo began working on a different model in his dorm room while he was an engineering student Penn. I was a student in biology and computer science and we met up and formed BioBots.. Q: Startup money?. A: Weve been bootstrapping but have $150,000 invested in the company, including $50,000 from DreamIt. Other investors are Ben Franklin Technology Partners, Wharton and Penn.. Q: Whats the biz do?. A: Weve built a high-resolution, desktop bioprinter that builds functional 3-D tissue. Eventually the goal is to get these 3-D tissues implanted into people and achieve re-creation of an artificial organ.. Q: The value prop?. A: Our device builds 3-D structures out of biocompatible materials. Theyre polymers, like ...

Photoacoustic images of a brain tumor after nanoparticle injection. The grey ultrasound image shows the skin and the skull margin, and the green signal indicates the nanoparticle distribution. Image adapted from Guo et al., Mater. Horiz., 2017, Advance Article with permission from The Royal Society of Chemistry. Nanoparticles were made from benzodithiophene-benzobithiadiazole donor-acceptor pairs co-polymerized and nanoprecipitated using biocompatible materials. When these imaging nanoparticles were applied to mice with orthotopic brain tumors, tumors 3.4 nm below the skull were resolved with a nearly 100-fold increase in photoacoustic signal compared to before intravenous administration of nanoparticles. The stable, high contrast photoacoustic imaging nanoparticle presented in this work offers a versatile platform for simple chemical modifications such as ligand targeting or drug loading.. Future work remains on the horizon to advance these materials for imaging through the ~5 mm thickness of ...

TY - JOUR. T1 - Amine-Functionalized Electrically Conductive Core-Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell-Biomaterial Interactions. AU - Borah, Rajiv. AU - Ingavle, Ganesh C.. AU - Sandeman, Susan R.. AU - Kumar, Ashok. AU - Mikhalovsky, Sergey V.. N1 - Funding Information: The authors cordially acknowledge British Council, U.K., and Department of Biotechnology (DBT), Government of India for the financial support through Newton-Bhabha scheme to carry out this work at University of Brighton, U.K. This research work was also partially supported by Department of Science & Technology (DST), Government of India, through Inspire Fellowship Scheme. The authors are thankful to Dr. Santanu Ray, School of Environment and Technology, University of Brighton, U.K., for his help during XPS measurement. The authors also gratefully acknowledge the help extended by Dr. Andrew Flint, Image and Analysis unit, University of Brighton, during SEM and confocal microscopy. Publisher Copyright: © ...

A customized dental prosthesis for periodontal or osseointegration is disclosed having a manufactured implant portion shaped to substantially conform to the three-dimensional surface of a root of a tooth to be replaced. Furthermore a CAD/CAM based method of and a system for manufacturing a customized dental prosthesis replacing an extracted tooth is disclosed, where the extracted tooth is scanned regarding its three-dimensional shape and substantially copied using (a) an imaging system in-vitro like a 3D scanner or in-vivo like a cone beam CT system, (b) CNC machinery and (c) biocompatible material that is suitable to be integrated into the extraction socket and at least partially adopted by the existing tissue forming the socket.

The same Ohio State research team is also developing magnetic particles to enhance medical imaging of cancer, and it may be possible to combine magnetism with the quantum dot technology for different kinds of imaging. But before the particles would be safe to use in the body, they would have to be made of biocompatible materials. Carbon-based nanomaterials are one possible option ...

One of the issues with microfluidic devices in life sciences is that most platforms rely on materials or chemicals that are outside the biological breadth as building blocks, scaffolds, or coatings for the devices. In a game-changing approach, researchers are developing a transformative way to fabricate microfluidic devices, where solid walls are replaced by transparent, morphing fluid walls using only biocompatible materials. This novel method can generate cell-friendly microfluidic devices on demand with features below 50 microns in size.

Chicago, IL , Posted on February 7th, 2012. At the heart of the NanoFabrication Systems contract services program is its DPN nanofabrication instruments capable of constructing complex multiplexed patterns of biocompatible materials at sub- cellular scales. This capability can be utilized to construct defined microenvironments for attaching live single cells and subsequently investigating cellular responses. Single cells (up to 5,000 individual cells on a single NanoInk chip) can be exposed to different external stimuli (including biological, chemical and topographical stimuli) and the downstream effects of these stimuli can be monitored at the cellular, proteomic or genomic levels. Additionally, studies on limited or rare cells harvested from a patient can potentially be exposed to many conditions, making theranostic applications possible. This new contract services program will enable researchers to engage NanoInk to design, develop and construct custom single cell assays ...

Your endodontist will examine and x-ray your tooth and then administer a local anesthetic. Once the tooth is numbed, the dentist will place a protective sheet over the area, which allows them to isolate the tooth with the problems. This also keeps the area clean and free from saliva while the procedure is done.. The dentist then makes an opening in the crown of the tooth. Tiny instruments will be used to clean the pulp from the pulp chamber and the root canals. They are also used to shape the space for proper filling.. Once space is shaped and clean, the endodontist will fill the root canal with a biocompatible material, sometimes a material that is rubber-like and called gutta-percha. This material is placed with an adhesive cement to ensure that there is a complete sealing of the root canals. In many cases, the dentist will use a temporary filling to close the opening. That will be removed later before the tooth is restored.. After your last visit with the endodontist, you will return to the ...

TY - JOUR. T1 - Thermo-debonding mechanisms in dentin bonding systems using finite element analysis. AU - Lee, Sheng Yang. AU - Chiang, Hsin Chih. AU - Huang, Haw Ming. AU - Shih, Yung Hsun. AU - Chen, Hsin Chung. AU - Dong, De Rei. AU - Lin, Che Tong. N1 - 被引用次數：24 Export Date: 9 August 2016 CODEN: BIMAD 通訊地址: Lee, S.-Y.; Grad. Inst. Oral Rehabilitation Sci., Taipei Medical College, 250 Wu-Hsing Street, Taipei, Taiwan; 電子郵件： [email protected] 化學物質/CAS: Biocompatible Materials; Dentin-Bonding Agents; Optibond; Resin Cements; Scotchbond Multi-Purpose 商標： Clearfil Protect liner, Kuraray, Japan; Dentin; Hybrid layer; Optibond; Scotchbond MP; Tenure; Z100 製造商： Kuraray, Japan 參考文獻: Van Noort, R., Cardew, G.E., Howard, I.C., A study of the interfacial shear and tensile stresses in a restored molar tooth (1988) J Dent, 16, pp. 286-293; Van Noort, R., Noroozi, S., Howard, I.C., Cardew, G.E., A critique of bond strength measurements (1989) J ...

Review A Review of Endoscopic Treatment of Hydrocephalus in Paediatric and Adult Patients Ji Min Ling, MB.ChB (UK), MMed Surgery (NUS), Rajendra Tiruchelvarayan, MBBS, FRCS (Neurosurgery) (Ireland) Department of Neurosurgery, National Neuroscience Institute, Singapore Abstract Endoscopic treatment for hydrocephalus started in the early 20th century, but could not thrive due to poor illumination and magnification of the scope. In the 1950s, ventriculoperitoneal (VP) shunt became widely acceptable as standard treatment for hydrocephalus owing to the invention of well-designed valves and discovery of silicone, a biocompatible material for manufacturing shunt catheters. However, shunting is still far from being an ideal treatment because of its associated complications such as catheter malposition, blockage, and over- or under-drainage of cerebrospinal fluid. The shunt revision rates remained high in recent series. At the same time, endoscopy has undergone tremendous improvement in the latter half ...

We demonstrate the use of a THz penetration-enhancing agent (THz-PEA) to enhance the terahertz (THz) wave penetration depth in tissues. The THz-PEA is a biocompatible material having absorption lower than that of water, and it is easily absorbed into tissues. When using glycerol as a THz-PEA, the peak value of the THz signal which was transmitted through the fresh tissue and reflected by a metal target, was almost doubled compared to that of tissue without glycerol. THz time-of-flight imaging (B-scan) was used to display the sequential glycerol delivery images. Enhancement of the penetration depth was confirmed after an artificial tumor was located below fresh skin. We thus concluded that the THz-PEA technique can potentially be employed to enhance the image contrast of the abnormal lesions below the skin ...

The global biomaterials market is estimated at $66.12 Billion in 2015 and is poised to reach $125.152 Billion by 2020, growing at a CAGR of 14% during the forecast period. Biomaterials are the combination of elements, artificial or naturally derived, used in medical applications for instance replacement of tissue and organ transplantation.. Browse the report: http://www.orbisresearch.com/reports/index/biomaterials-market-by-material-type-by-application-and-by-region-global-industry-analysis-size-share-growth-trends-and-forecast-2016-2021. Advancements in medical technology have taken a hefty toll on plastic materials that are used in medical applications, which has been further worsened by developments in the fields of medical plastic, stainless steel /titanium metal replacement implant materials, being predominantly driven by concerns of biocompatibility, in addition to demand for superior implant mechanical performance.. Increased use of biomaterials is mainly attributed to the tremendous ...

Job description. The research activity will by focused on coating model substrates, such as, polymeric blood vessel prostheses currently used by cardiovascular surgery, scaffolds prepared by decellularization of biological blood vessels or heart valves, and neurovascular stents, with artificial fibrin gels containing various bioactive molecules capable of specific interactions with selected cells.. The coating should provide a graft with blood compatibility and support the creation of natural endothelium on its surface. As most current artificial grafts fail after some time in organism, the development of bioactive coatings is an essential objective for several interdisciplinary projects seeking to new generation of cardiovascular grafts.. The researchers activity will include the optimization of the coating structure and composition in response to experimental results provided continuously by collaborating teams of cell biologists (Institute of Physiology ASCR, Prague), designer of the grafts ...

TY - JOUR. T1 - Quantifying the interactions between biomimetic biomaterials - collagen I, collagen IV, laminin 521 and cellulose nanofibrils - by colloidal probe microscopy. AU - Nugroho, Robertus Wahyu N.. AU - Harjumäki, Riina. AU - Zhang, Xue. AU - Lou, Yan Ru. AU - Yliperttula, Marjo. AU - Valle-Delgado, Juan José. AU - Österberg, Monika. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Biomaterials of different nature have been and are widely studied for various biomedical applications. In many cases, biomaterial assemblies are designed to mimic biological systems. Although biomaterials have been thoroughly characterized in many aspects, not much quantitative information on the molecular level interactions between different biomaterials is available. That information is very important, on the one hand, to understand the properties of biological systems and, on the other hand, to develop new composite biomaterials for special applications. This work presents a systematic, quantitative analysis of ...

A schematic process flow of the synthesis of Ag@SiO2@mSiO2 nanocarrier: (a) Monodispersed silver nanoparticles. (b) Depositing thin SiO2 layer (~10 nm in thickness) on the surface of Ag nanoparticles using TEOS as silicon source. (c) Coating mesoporous SiO2 layer (~35 nm in thickness) on the basis of Ag@SiO2 nanospheres by introducing CTAB as template and followed by CTAB removal. A schematic diagram of the fabrication procedure for modified microfiber sensor with mesoporous nanostructures: (d) As-prepared microfiber device by tapering technique. (e) Cleaning microfiber with ethanol and piranha solution. (f) Amino groups with positive charges bonding to abundant hydroxyl groups on the surface of fresh microfiber with APTES. (g) Implementing the functionalized fiber device under the circumstances of nanospheres with negative charges. Top-view SEM image of dispersed Ag@SiO2 nanospheres and Ag@SiO2@mSiO2 with higher amplification factor are shown in panels (h) and (i), respectively. (j) Side-view ...

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Biomaterials Engineering and Technologies scheduled on February 10-11, 2020 in February 2020 in Kuala Lumpur is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums.

Biomaterials, Colloids and Nanomedicine scheduled on June 14-15, 2021 in June 2021 in Montreal is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums.

Cobra Quik Clenz Buffing Pad & Microfiber Cleaner (3 Pack) - Clean and restore foam and wool buffing pads! Cobra Quik Clenz Buffing Pad & Microfiber Cleaner is a concentrated degreaser and cleaner specially formulated for foam and wool buffing pads. Dissolve a packet in 2-3 gallons of water to create a powerful degreaser. Cobra Quik Clenz powers through caked-on polishes and waxes to leave pads feeling and performing like new. You can get more use out of your buffing pads with the right care. Cobra Quik Clenz dissolves product residues within the cells of foam pads, leaving the foam supple and clean. In wool pads, dried polish stiffens the wool fibers and mats the wool together. Quik Clenz releases caked-on polishes to restore the usable texture of both foam and wool pads. Cobra Quik Clenz is a biodegradable cleaner with natural citrus extracts that emulsify products caked within the foam, wool, and microfiber. This is an environmentally friendly, nonflammable product. We recommend mixing up a bucket

Acellular matrix obtained from homologous muscular tissue has been previously used to repair muscular defects. However, the implants, although not rejected, give rise to an intense inflammatory response and are rapidly replaced by fibrous tissue. In this study we examined the possibility that co-culture with autologous satellite cells can improve the efficiency of homologous acellular matrix as skeletal muscle substitute. Satellite cells, isolated from rat dorsal muscle, were cultured in vitro on homologous acellular matrix obtained by detergent-enzymatic treatment of abdominal muscle fragments. Scanning electron microscopy revealed that after 24 h of co-culture satellite cells were attached to the matrix, but still possessed a round shape. After 96 h, seeded cells began to flatten and to differentiate, originating few multinucleated myotubes. Patches of homologous matrix, seeded or not with autologous satellite cells, were implanted in the dorsal muscle of rats. At autopsy, the implants were ...

This paper aims to discuss and review developments in plasma surface modification techniques which have been seen over the past few years, with particular emphasis on low energy or soft plasma assisted surface polymerisation processes. While early work focussed mainly on protective coatings and surface activation, the advancements in microtechnology in the 1980s followed by those in nanotechnology in the 1990s and 2000s have resulted in new challenges for surface processing and surface modification processes. The latest advancements in plasma polymer chemistry have shown tremendous potential for the synthesis of reasonably well defined molecular structures with a high retention of functional groups. Some of the latest achievements and newest insights into the behaviour of such deposits in a liquid environment will be discussed, with a particular focus on bionanotechnological applications. Utilising novel approaches in surface and interface analysis, it will be shown that plasma polymers can be ...

1996 (English)In: 3: rd Meeting and Seminar on : Ceramics,Cells and Tissues, (Ed. Ravaglioli,A. and Krajewski,A.). Gruppo editoriale faenza editrice s.p.a., 1996, 171-178 p.Conference paper, Published paper (Other scientific) ...

Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...

TY - JOUR. T1 - Scale-up study of high osmotic pressure chromatography for separation of poly(ε-caprolactone). AU - Lee, Dean. AU - Teraoka, Iwao. PY - 2003/5/9. Y1 - 2003/5/9. N2 - Methods to prepare fractions of poly(ε-caprolactone) with a narrow molecular mass distribution in large quantities have been examined using high osmotic pressure chromatography under the theta condition. Effects of column dimension and coupling columns in series on the separation resolution were studied. We found that use of a thicker column can improve the resolution if adverse effects of viscous fingering are avoided. We also demonstrated that coupling the columns results in a better separation if the second column does not adsorb high-molecular-mass components purified in the first column.. AB - Methods to prepare fractions of poly(ε-caprolactone) with a narrow molecular mass distribution in large quantities have been examined using high osmotic pressure chromatography under the theta condition. Effects of ...

Degradable polymers with a tailorable degradation rate might be promising candidate materials for biomaterial-based cartilage repair. In view of the poor intrinsic healing capability of cartilage, implantation of autologous chondrocytes seeded on a biocompatible slow degrading polymer might be an encouraging approach to improve cartilage repair in the future. This study was undertaken to test if the fiber orientation (random versus aligned) of two different degradable polymers and a polymer intended for long term applications could influence primary articular chondrocytes growth and ultrastructure. A degradable copoly(ether) esterurethane (PDC) was synthesized via co-condensation of poly(p-dioxanone) diol and poly(epsilon-caprolactone) diol using an aliphatic diisocyanate as linker. Poly(p-dioxanone) (PPDO) was applied as commercially available degradable polymer, while polyetherimide (PEI) was chosen as biomaterial enabling surface functionalization. The fibrous scaffolds of PDC and PPDO were ...

Optimized electrospinning conditions were applied to produce single and multilayered (ML) scaffolds composed of polycaprolactone, collagen and elastin. The ML scaffold was cross-linked with glutaraldehyde to increase the stability. Morphological and structural characteristics of the scaffolds were measured by SEM and FTIR analyses. Results revealed that polymers combined to each other well and uniform fibers were obtained with the diameters ranging from 156 +/- 53 to 1536 +/- 293 nm. Contact angle measurements were performed to investigate the hydrophilic character of each structure. It was observed that incorporation of the natural polymers into the blends increased the hydrophilicity. Mechanical tests proved that collagen contributed to fabricate stiffer structures while elastin provided more elasticity. Biocompatibility of the scaffolds was examined by SEM analysis and WST-1 test with mouse fibroblast cells (L929) in vitro. Results exhibited that the addition of natural polymers increased the ...

Develop Biosystem: Develop Biosystem is a technology based company whose main activity is focused on research, development and subsequent technology transfer of new biomaterials for tissue engineering.. Our areas of application, is currently in the RGO (bone regeneration) in dental/maxillofacial surgery and Traumatology, but with projects open in the field of the RGST (soft tissue regeneration) - RGC (Articular cartilage regeneration) and RGN (regeneration of nervous tissue). Develop Biosystem is willing to contribute to any project related to the development of new biomaterials and tissue engineering useful for innovative medical technologies.. ...

The aim of this work has been the preparation and characterization of novel hydrogels with polysaccharide-poly(amino acid) structure having suitable physicochemical properties for pharmaceutical applications. In the first step, hyaluronic acid (HA) and ?,?-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) have been derivatized with methacrylic anhydride (AMA), thus obtaining HA-AMA and PHM derivatives, respectively. In the second step, aqueous solutions of both these derivatives have been irradiated at 313 nm to obtain chemical hydrogels. The hydrogel obtained by irradiating for 15 min an aqueous solution containing 4% w/v of HA-AMA and 4% w/v of PHM resulted in the highest yield. Its swelling ability was dependent on the pH and nature of the external medium. Besides, this hydrogel undergoes a partial hydrolysis, especially in the presence of enzymes, such as esterase or hyaluronidase, but the entity of this degradation is lower than that observed for a hydrogel based on HA-AMA alone. The ability of ...

Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review ...

TY - JOUR. T1 - Immunomodulatory Potential of Chitosan-graft-poly(ϵ-caprolactone) Copolymers toward the Polarization of Bone-Marrow-Derived Macrophages. AU - Papadimitriou, Lina. AU - Kaliva, Maria. AU - Vamvakaki, Maria. AU - Chatzinikolaidou, Maria. N1 - Publisher Copyright: © 2016 American Chemical Society. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2017/7/10. Y1 - 2017/7/10. N2 - In tissue engineering, the use of biomaterials as templates or scaffolds to guide tissue development in vivo provokes the inevitable action of the immune system of the host. This induced immune response often determines the success of the scaffold, including angiogenesis and regeneration or failure causing inflammation and fibrosis. Therefore, it is crucial to predict or even better to promote the proper immune response following implantation. The aim of the present study was to evaluate the immunomodulatory potential of chitosan-graft-poly(ϵ-caprolactone) copolymers (CS-g-PCL) by ...

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Due to the increasing prevalence of resistance of bacteria to antibiotics and antiseptic methods, new strategies to prevent colonization of biomaterials are needed. Due to its high antimicrobial activity and relatively low toxicity to human cells, we are evaluating silver (Ag) releasing plasma polymers as a strategy to prevent bacterial colonization. Such Ag/plasma polymer nanocomposite materials, consisting of nano-scaled metal clusters embedded within a plasma-polymer matrix can be deposited using a mixed, plasma polymerization /sputtering process. For example, Ag containing plasma polymer nanocomposites are deposited employing an Ag cathode, an appropriate monomer to yield the desired material properties of the matrix (biocompatibility) and an asymmetric reactor design. The focus of this paper is a new development at Empa: a multi-functional Ag/amino-hydrocarbon (Ag/a-C:H:N) nanocomposite that can enhance cell growth and simultaneously prevent bacterial colonization at surfaces. Ag/a-C:H:N ...