US demand for biocompatible materials is forecast to increase 4.9 percent annually to $5.6 billion in 2018. Ceramic materials will grow the fastest based on improved nanotechnology compounds for orthopedic implants, spinal fixation devices and dental products. Natural polymers will be the second fastest growing segment, paced by hyaluronic acid.This study analyzes the $4.4 billion US biocompatible materials industry. It presents historical demand data (2003, 2008 and 2013) and forecasts (2018 and 2023) by product (e.g., synthetic polymers, natural polymers, ceramics, metals) and application (e.g., surgical and medical instruments, surgical appliances and supplies, dental products and materials, drug delivery products, electromedical equipment, diagnostic products, ophthalmic goods).The study also considers market environment factors, details industry structure, evaluates company market share and profiles 31 industry players, including Dow Chemical, BASF and PolyOne.
A method of permanently modifying the surface of a substrate material so as to develop a microscopically smooth, biocompatible surface thereon comprises covalently grafting at least a first biocompatible material, preferably having pendant terminal carboxylic acid or amine groups, to the surface of the substrate material by radio frequency plasma-induced grafting. In addition, a method of permanently modifying the surface of the substrate material comprises cross-linking a second biocompatible material to the first biocompatible material grafted to the substrate material using a cross-linking agent. Further, a prosthesis used in mammals, including an intraocular lens, comprises a polymer core and at least a first biocompatible material, preferably having pendant terminal carboxylic acid or amine groups, covalently grafted to the polymer core by radio frequency plasma induction. The prosthesis used in mammals may further comprise a second biocompatible material cross-linked to the grafted first
A flexible covered stent includes a stent covered on a first surface by a first layer of biocompatible material and on a second surface by a second layer of biocompatible material, the first and second layers of biocompatible material being bonded to one another through a wall in the stent. The first layer of biocompatible material is longer than the second layer of biocompatible material such that at least a portion of the second surface of the stent is left uncovered, imparting flexibility to the stent. A mid portion of the second surface of the stent can be left uncovered to impart flexibility to the stent similar to that enjoyed by a bare stent.
We present in this category the monomers used for biomaterials research classified according to their chemical structures such as acrylic monomers, lactone monomers, dithiol monomers, and diisocyanate monomers. Among them acrylic monomers contain largest number of products and are often utilized for biomaterials or biocompatible materials research, using conventional radical polymerization or controlled radical polymerization. In addition to the common monomers for biomaterials research including 2-hydroxyethyl methacrylate (HEMA) [M0085]1) and N-isopropylacrylamide (NIPAAm) [I0401]2), TCI has zwitterionic monomers or monomers with reactive functional groups useful for conjugation with proteins or peptides present in our catalog. Zwitterionic monomers contain both cationic and anionic groups in the same molecule. Common zwitterionic monomer structures include phosphobetaines, sulfobetaines, and carboxybetaines.3,4) One of the phosphobetaine zwitterionic monomers, 2-(methacryloyloxy)ethyl 2-
A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated material. The cell adhesion stimulating protein can be a structural protein or a polypeptide growth factor, such as vascular endothelial growth factor. Viable cells can be adhered in vivo or in vitro to the biocompatible material with the cell adhesion stimulating protein.
Cell-material adhesions are fundamental in cell biology. Not only the chemical identity of the material, but also the spatial and temporal presentation of the adhesion molecules determine how different cell types interact with a material and activate signaling. Hence, the design of cell-instructive materials for studying cell biology and applications in tissue engineering, medical implants and cell-based screening all require independent spatiotemporal control of cell-material interactions, not just for one but for multiple cell types. By using photoswitchable proteins that respond to different colors of light, we want to photochemically control the cell-material interactions for multiple cell types. Manipulating cell-material interactions photochemically will give us control over cell adhesion with high spatial and temporal resolution, making it possible to study and manipulate intercellular processes such as collective cell migration and differentiation, and intracellular processes such as ...
|p|Silicon Carbide (SiC) is a wide-band-gap semiconductor biocompatible material that has the potential to advance advanced biomedical applications. SiC devices offer higher power densities and lower energy losses, enabling lighter, more compact and higher efficiency products for biocompatible and long-term in vivo applications ranging from heart stent coatings and bone implant scaffolds to neurological implants and sensors.|/p| |p|The main problem facing the medical community today is the lack of biocompatible materials that are also capable of electronic operation. Such devices are currently implemented using silicon technology, which either has to be hermetically sealed so it cannot interact with the body or the material is only stable in vivo for short periods of time. |/p| |p|For long term use (permanent implanted devices such as glucose sensors, brain-machine-interface devices, smart bone and organ implants) a more robust material that the body does not recognize and reject as a foreign (i.e., not
This thesis deals with novel aspects through Nanotechnologyofbottom-upandtop-downstrategies in combination with Biotechnology as aninterdisciplinary study. The feasibility of chemically tailoredsuperparamagnetic iron oxide nanoparticles (SPION) forin-vivobiomedical applications has beendemonstrated.. The main objects of the present thesis are to design thesurface modified SPION with biocompatible agents, varying fromorganic to polymer and biocompatible materials such asproteins. The particles have been applied to intact organs ofliving animals (rat brain) to examine how they interactpreferentially in the brain tissue and to confirm thefeasibility of the SPION for biomedical applications using MRimaging as an exogenous contrast media.. Several different types of materials including SPION (firstgeneration), immobilization of biocompatible materials on SPION(second generation), forin-vivobiomedical applications and nanowires andnanotubes have been approached from the aspect ofNanotechnology. ...
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organisms reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organisms reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
Commercial sunscreens contain two types of compounds to block both longwave UV-A light that may cause cancer and shortwave UV-B light that causes sunburn. Some fish, algae, and cyanobacteria produce amino acids called mycosporines that absorb both UV-A and UV-B light. To develop more effective, biocompatible sunscreens, some manufacturers have added mycosporines to their formulations. But free mycosporine molecules can diffuse through a smear of sunscreen, making it difficult for the UV-blocking agents to stay where they are applied.. ...
A flexible stent having a waveform pattern formed from a sheet of biocompatible material and into a tubular shape for maintaining the patency of a lumen such as in a coronary vessel. The waveform pattern of the stent is formed from a flat sheet of malleable, biocompatible material by, for example, photochemically etching the sheet and leaving a framework or plurality of closed cells. The waveform pattern is formed into a tubular shape around a deflated, delivery catheter balloon with segments of the closed cells being interposed only overlapping a reinforcing member extending longitudinally along the stent. The stent material is treated to reduce the coefficient of friction of the material and to aid in the radial expansion of the stent with the balloon. Radiopaque markers are positioned at the ends of the stent to aid the physician in positioning the stent at an occlusion site.
Background The cell-material interaction is a complex bi-directional and dynamic process that mimics to a certain extent the natural interactions of cells with the extracellular matrix. Cells tend to adhere and rearrange adsorbed extracellular matrix (ECM) proteins on the material surface in a fibril-like pattern. Afterwards, the ECM undergoes proteolytic degradation, which is a mechanism for the removal of the excess ECM usually approximated with remodeling. ECM remodeling is a dynamic process that consists of two opposite events: assembly and degradation. Methodology/Principal Findings This work investigates matrix protein dynamics on mixed self-assembled monolayers (SAMs) of -OH and -CH3 terminated alkanethiols. SAMs assembled on gold are highly ordered organic surfaces able to provide different chemical functionalities and well-controlled surface properties. Fibronectin (FN) was adsorbed on the different surfaces and quantified in terms of the adsorbed surface density, distribution and
An apparatus and method for making an occlusion device for occluding a body vessel. The apparatus and method include providing a frame and a mandrel. The frame has a hub extending along a longitudinal axis from a proximal end to a distal end. A plurality of arcuate legs are attached to the hub and extend distally. The arcuate legs are flexible and have inner surfaces defining an inner profile in an unconstrained state. The mandrel has an outer surface corresponding to the inner profile of the occlusion device. A base layer of a biocompatible material is disposed on the outer surface of the mandrel. The frame is placed on the outer surface with the base layer between the frame and the mandrel. The frame is attached to the base layer such that the biocompatible material forms a membrane extending along and between the arcuate legs.
Ver más] Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product. Cell-biomaterial interaction is referred to here as the phenomenon involved in adherent cells attachment to the biomaterial surface, and their related cell functions such as growth, differentiation, migration or apoptosis. This process is inherently complex in nature involving many physico-chemical events which take place at different scales ranging from molecular to cell body (organelle) levels. Moreover, it has been demonstrated that the mechanical environment at the cell-biomaterial location may play an important role in the subsequent cell function, which remains to be elucidated. In this paper, the state-of-the-art research in the physics and mechanics ...
Despite extensive preventative efforts, the problem of controlling infections associated with biomedical materials persists. Bacteria tend to colonize on biocompatible materials and form biofilms; thus, novel biomaterials with antibacterial properties are of great interest. In this thesis, titanium dioxide (TiO2)-associated photocatalysis under ultraviolet (UV) irradiation was investigated as a strategy for developing bioactivity and antibacterial properties on biomaterials. Although much of the work was specifically directed towards dental materials, the results presented are applicable to a wide range of biomaterial applications.. Most of the experimental work in the thesis was based on a resin-TiO2 nanocomposite that was prepared by adding 20 wt% TiO2 nanoparticles to a resin-based polymer material. Tests showed that the addition of the nanoparticles endowed the adhesive material with photocatalytic activity without affecting the functional bonding strength. Subsequent studies indicated a ...
AbstractOptical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a
Center for Hierarchical Manufacturing: Diseases and disorders of cartilage tissue are one of the leading causes of disability in the US. However, many biocompatible materials do not have sufficient mechanical strength and elasticity to serve as scaffolds for cartilage repair. University of Massachusetts Amherst researchers Surita Bhatia and Gregory Tew have developed techniques to disperse nanosized discs within biocompatible polymer matrices, resulting in biocompatible gels with superior control over mechanical properties. By varying the loading and surface chemistry of the nanodiscs, the elasticity of these materials can be tuned to match the mechanical properties of several soft tissues, including cartilage. Initial results also suggest that the presence of the nanodiscs result in improved cell viability.. ...
Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bioincompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bioincompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.
Edited by: Prof Jeong-Yeol Yoon. The well-studied tissue interaction with biomaterials has inspired a blossoming field of alternative uses for these substrates. Current methods for scaffold fabrication include hydrogels, 3D printed biocompatible materials, and other bio-inspired tissue engineered implants. Traditional study of such biomaterials has primarily focused on the implants used in vivo. The recent surge in alternative uses for biomaterials has pushed for the investigation of intravenous drug and gene delivery carriers and the use of biomaterials for lab-on-a-chip (LOC) applications, particularly stem cell differentiation and cancer studies. This thematic series highlights these exciting new trends in biomaterials.. If you are interested in submitting a manuscript for this thematic series, please contact the series editor, Jeong-Yeol Yoon, with a title and an abstract. The series will run throughout 2015.. This collection of articles has not been sponsored and articles have undergone the ...
Mansoor Amiji, Ph.D., Associate Professor of Pharmaceutical Sciences in the School of Pharmacy, Bouve College of Health Sciences and Associate Director of the Nanomedicine Consortium, Northeastern University in Boston, MA. Dr. Amiji received his undergraduate degree in pharmacy from Northeastern University in 1988 and his Ph.D. in pharmaceutics/biomaterial science from Purdue University in 1992. His areas of specialization include polymeric biomaterials, drug delivery systems, and nanomedical technologies. Dr. Amiji s research interests include synthesis of novel polymeric materials for medical and pharmaceutical applications; surface modification of cationic polymers by the complexation-interpenetration method to develop biocompatible materials; preparation and characterization of polymeric membranes and microcapsules with controlled permeability properties for medical and pharmaceutical applications; target-specific drug and vaccine delivery systems for gastrointestinal tract infections; ...
Dr. Amiji received his undergraduate degree in pharmacy from Northeastern University in 1988 and his PhD in pharmaceutics from Purdue University in 1992. His areas of specialization include polymeric biomaterials, advanced drug delivery systems, and nanomedical technologies.. Dr. Amijis research interests include synthesis of novel polymeric materials for medical and pharmaceutical applications; surface modification of cationic polymers by the complexation-interpenetration method to develop biocompatible materials; preparation and characterization of polymeric membranes and microcapsules with controlled permeability properties for medical and pharmaceutical applications; target-specific drug and vaccine delivery systems for gastrointestinal tract infections; localized delivery of cytotoxic and anti-angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles intracellular delivery systems for drugs and genes using target-specific, long-circulating, biodegradable polymeric ...
Dr. Amiji received his undergraduate degree in pharmacy from Northeastern University in 1988 and his PhD in pharmaceutics from Purdue University in 1992. His areas of specialization include polymeric biomaterials, advanced drug delivery systems, and nanomedical technologies.Dr. Amijis research interests include synthesis of novel polymeric materials for medical and pharmaceutical applications; surface modification of cationic polymers by the complexation-interpenetration method to develop biocompatible materials; preparation and characterization of polymeric membranes and microcapsules with controlled permeability properties for medical and pharmaceutical applications; target-specific drug and vaccine delivery systems for gastrointestinal tract infections; localized delivery of cytotoxic and anti-angiogenic drugs for solid tumors in novel biodegradable polymeric nanoparticles intracellular delivery systems for drugs and genes using target-specific, long-circulating, biodegradable polymeric
Natural biopolymer nanoparticles (NPs), including nanocrystalline cellulose (CNC) and lignin, have shown potential as scaffolds for targeted drug delivery syste...
Description. Biomaterials are substances that have been designed to direct the course of any therapeutic or diagnostic procedure by controlling interactions with biological systems. A large toolbox of non-biological materials has been engineered to study cell behavior at the cell-material interface. In this course, we will examine how this interface can be leveraged to study cellular systems and generate novel therapeutics. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong int Biomaterials are substances that have been designed to direct the course of any therapeutic or diagnostic procedure by controlling interactions with biological systems. A large toolbox of ...
A continuous glucose sensor employing radio frequency (RF) signals is presented using the biocompatible material Silicon Carbide (SiC). Unlike biosensors that require direct contact with interstitial fluids to trigger chemical reactions to operate, this biocompatible SiC sensor does not require a direct interface. The sensing mechanism for this SiC sensor is based upon a shift in resonant frequency, as a function of change in glucose levels, which electrically manifests itself as a change in blood permittivity and conductivity. For in vivo applications the antenna sensor needs to operate inside the body environment, and it has been found that the best operational location of this biocompatible SiC sensor is within fatty tissue in close proximity to blood vessels. To test glucose levels, measurements using synthetic body fluid (SBF), which is electrically equivalent to blood plasma, were performed. Changes in sensor performance to varying glucose levels were measured and a shift in resonant frequency to
Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery Jae Yeon Joo, GilYong Park, SeongSoo A An Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam-si, Republic of Korea Abstract: In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine–glycine–aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow
You are planning to produce an implant that consists of an alloy or coating that has not been used yet? We test the biocompatibility of your products according to ISO 10993 and check if the material is biological inert. Moreover, we make sure, that there will be no damage to the surrounding tissue.. An important safety issue while developing medical products is biocompatibility. senetics offers you to perform different tests to ensure that your materials are biocompatible!. Biocompatible materials do not have a toxic or hazardous effect on biological systems. As medical devices and implants are in direct contact with the surrounding tissue for a long time, they must not cause defense reactions of the immune system. After the German Medical Devices Act, medical devices must be tested extensively before being placed to protect the patients. We offer the following services:. ...
Author: Tan, I. et al.; Genre: Journal Article; Published in Print: 2009-09; Keywords: thermoresponsive chromatography; bioseparation; thermoresponsive polymers; ATRP; grafting; HPLC; Title: PEGylated Chromatography: Efficient Bioseparation on Silica Monoliths Grafted with Smart Biocompatible Polymers
Fingerprint Dive into the research topics of Studies on molecular structure of biocompatible polymers by vibrational spectroscopy [17] sorption of small molecules. Together they form a unique fingerprint. ...
Rising Usage of Natural & Synthetic Biomaterials for Cardiac Repair to Aid Growth Cardiovascular diseases are considered to be one of the major causes of death worldwide. Even though there are multiple pharmacological and surgical interventions that can be applied to enhance the quality of life of the patients affected by such diseases, less-invasive and cost-effective procedures are always more preferable. Both synthetic and natural biomaterials showcase high potential in cardiac regeneration and repair. Nowadays injectable biomaterials are used the most as they preserve cardiac functions, increase angiogenesis, and reduce left ventricular dilatation. However, there are numerous strict regulatory and clinical processes that the biomaterial-based devices have to go through to ensure their quality and efficacy. It may hamper the implantable biomaterials market growth. The emergence of COVID-19 has brought the world to a standstill. We understand that this health crisis has brought an ...
Biomaterials in blood-contacting devices by Meng-Jiy Wang; 1 edition; First published in 2009; Subjects: Blood Coagulation, Platelet Adhesiveness, Biocompatible Materials, Polymers in medicine, Thrombosis, Biocompatibility, Adverse effects, Prevention & control, Physiology
The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device.
Autori: zaharia c., moreau m.f., zecheru t., marculescu b., filmon r., cincu c., basle m.f., chappard d. Editorial: 34th european symposium on calcified tissues, copenhagen, 2007.. Rezumat:. Poly(methyl methacrylate -pMMA) is used as dental or bone cement. A major drawback of the polymeric biomaterials is that they are radiolucent since they hardly absorb X-ray radiation due to the absence of heavy elements within their structure ...
Nano-Hydroxyapatite (nHAP) is a very valuable mineral that is widely used in tissueengineering as well as bone and dental repair. Moreover, it is a major component of bone, enamel and dentin that can interact effectively with healing tissues due to its high biocompatibility. It is important to note that the purpose of its medical application can be identified based on the structure and synthesis of HAP. This study aimed to efficiently review all the previously conducted studies on synthesis and application of nHAP over the years of researchers efforts and present the results for optimizing biocompatible material synthesis.
TY - JOUR. T1 - Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial. AU - Caplan, Michael. AU - Schwartzfarb, Elissa M.. AU - Zhang, Shuguang. AU - Kamm, Roger D.. AU - Lauffenburger, Douglas A.. PY - 2002. Y1 - 2002. N2 - In order to elucidate design principles for biocompatible materials that can be created by in situ transformation from self-assembling oligopeptides, we investigate a class of oligopeptides that can self-assemble in salt solutions to form three-dimensional matrices. This class of peptides possesses a repeated sequence of amino acid residues with the type: hydrophobic/negatively-charged/hydrophobic/positively-charged. We systematically vary three chief aspects of this sequence type: (1) the hydrophobic side chains; (2) the charged side chains; and (3) the number of repeats. Each of these has been previously shown to influence the self-assembly properties of these materials. Employing a rheometric ...
An important challenge in many applications is the prevention of unwanted nonspecific biomolecular and microorganism attachment on surfaces. To address this challenge, our goals are twofold. First, we strive to provide a fundamental understanding of nonfouling mechanisms at the molecular level. Second, we aim to develop biocompatible materials based on the molecular principles learned. As a result, we have shown that zwitterionic materials and surfaces are highly resistant to nonspecific protein adsorption and microorganism attachment from complex media.. In this talk, in addition to design principles, I will discuss the application of zwitterionic material to implants, stem cell cultures for controlled preservation/expansion/differentiation, medical devices and drug delivery carriers. With zwitterionic coatings, hydrogels or nanoparticles, results show no capsule formation upon subcutaneous implantation in mice for one year, expansion of hematopoietic stem and progenitor cells (HSPCs) without ...
Research in the biomedical and life sciences is a robust part of the intellectual activity at IEN. Nanoscale approaches to the development of new biocompatible materials and medical devices play a vital role in technical advancement and innovation for applications as diverse as diagnostics, imaging, biosensors, drug delivery and therapeutics, and biomaterials and surface modification for implantable devices.. ...
Biocompatible materials with nano-scale structure hold great promise for controlled and targeted delivery and half-life extension of both small-molecule drugs and various classes of biologics, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Promising delivery systems include microcapsules, liposomes, macromolecular conjugates, nanoparticles, dendrimers, and biological stuctures such polypeptides, benign viruses and bacteriophages. This symposium will focus on commercially promising new materials and approaches. ...
Restorative Sciences & Biomaterials is at the forefront of developing materials for computerized fabrication of restorations. Our faculty have developed new concepts and techniques for analyzing the interaction between biomaterials and cells at the molecular and genetic levels. We have strategically positioned ourselves to create, analyze, and test novel synthetic materials for tissue replacement and prosthetic therapy.. The primary functions of Restorative Sciences & Biomaterials are:. ...
Shuhei Furukawa(古川修平) Address: Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, iCeMS Research Bldg, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan Tel: +81-75-753-9868 E-mail: [email protected] [Academic Career] 2017/Apr.-present: Associate Professor (PI): Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan 准教授(研究室主宰者):京都大学高等研究院物質ー細胞統合システム拠点 2010/Oct.-2017/Mar: Associate Professor: Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan 准教授:京都大学物質ー細胞統合システム拠点 2008/Jan.-2013/Mar: Group Leader, Hybrid…
A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner. The...
A wide range of cellular, macromolecular and particulate carriers of different sizes, which are made of diverse range of biodegradable/ biocompatible materials have been exploited as potential drug delivery systems with the aim of improving cancer chemo-therapy.
3. After the space is cleaned and shaped, the endodontist fills the root canals with a biocompatible material, usually a rubber-like material called gutta-percha. The gutta-percha is placed with an adhesive cement to ensure complete sealing of the root canals. In most cases, a temporary filling is placed to close the opening. The temporary filling will be removed by your dentist before the tooth is restored.. ...
The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods.
The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods.
Biomaterials †Khademhosseini Laboratory. The Journal mainly promotes the novel emerging Biomaterial applications to Medical Sciences like Biomaterials, Tissue Engineering Biomaterials Applications,, Buy Biomaterials for Tissue Engineering Applications from Dymocks online BookStore. Find latest reader reviews and much more at Dymocks. Biomaterials and Tissue Engineering MSc UCL Mechanical Engineering. Application and next steps. Applications. Students are advised Application fee: Biomaterials and scaffolds for tissue engineering OBrien F. Biomaterials and scaffolds for tissue the art of scaffolds for tissue engineering applications.. With advancements in biological and engineering sciences, the definition of an ideal biomaterial has evolved over the past 50 years from a substance that is inert to Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications Chengdong Jia, Ali Khademhosseinib,c,d, Fariba Dehghania,*. Interdisciplinary research into ...
Wearable medical devices such as continuous heart rate monitors, insulin pumps, and neural stimulators usually need access to an electric power source in order to function. While theres a great deal of wasted energy that our body emits that can be harvested to power such devices, making it actually happen using biocompatible materials has proven to be challenging. Now, a team of engineers at Purdue University has shown that polyvinyl alcohol (PVA), one of the most common polymers used in biomedicine, can be used to produce efficient triboelectric nanogenerators (TENGs) that can also act as cardiac activity monitors.. The PVA-based TENGs show great potential for self-powered biomedical devices and open doors to new technologies that use widely deployed biocompatible materials for economically feasible and ecologically friendly production of functional devices in energy, electronics and sensor applications, said Wenzhuo Wu, the leader of the research team. We transform PVA, one of the most ...
Biomaterials are further evolving. Biomaterials for hearing implants depend on components, structural polymers, and electrodes. Biomaterials have transformed the medical treatment of hearing loss. The ear dysfunction, hearing loss is able to be addressed and repaired via a device implant that leverages biomaterials. Alloplastic and homograft biomaterials have been used to restore hearing with ossicular replacement prostheses, cochlear implants, and implantable middle ear devices. Biomaterials are used in implantable middle ear devices and inner ear implants. Biomaterials for middle ear applications of implantable devices are significant. The site of implantation and the mass of the implant dictate the choice of biomaterials. Hermetic sealing of an implant is best achieved by the use of metals, not polymers. The Osteocompatibility of an ossicular implant can be enhanced by the incorporation of calcium phosphates such as hydroxyapatite coatings. The market research study provides insight into market
Mechanical performance and biocompatibility study of methacrylated Gellan gum hydrogels with potential for nucleus pulposus regeneration ...
This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and
Polyimide (PI) is a commonly used polymer in microelectronics. Recently, numerous PI-based flexible neural interfaces have been developed for reducing mechanical mismatch between rigid implant and soft neural tissue. Most approaches employ non-photosensitive PI, which has been proven earlier to be biocompatible. However, photosensitive polyimide (PSPI) would simplify device fabrication remarkably, but its biocompatibility has been only sparsely reported. In this study, cytotoxicity of spin-coated PSPI (HD Microsystems PI-2771) and conventional PI (HD Microsystems PI-2525) films were evaluated in vitro using BHK-21 fibroblasts according to the ISO-10993-5 standard. PSPIs were tested as cured at a temperature of 200 degrees C (PI-2771-200) and 350 degrees C (PI-2771-350). The PI film surfaces were characterized in terms of their roughness, energy and zeta potential which are hypothesized to affect cell-material interactions. The values of the total surface free energy (SFE), and its polar and ...
The term bioprinting refers to processes that bring biological materials such as cells, biomolecules and tissue preparations or biocompatible materials into a three-dimensional structure in order to fulfil a biological function.. While the Fraunhofer Institutes ILT, IFAM and IPA are working on the generative construction of improved orthopaedic implants and orthoses made of metal powders and synthetic materials, Fraunhofer IGB develops so-called biotools from biocompatible polymers, biological molecules from the natural tissue matrix and cells for the reconstruction of biological tissues.. In the future, natural, human tissue models should enable meaningful and individual diagnostic and pharmacological tests, avoid animal experiments and eventually also be available as implantable biological tissue sets. ...
F3088-14 Standard Test Method for Use of a Centrifugation Method to Quantify/Study Cell-Material Adhesive Interactions cell adhesion~ cell-to-material interaction~
TY - CONF. T1 - Nanodiamond-dotma Complexes As Effective Non-viral Vectors For Gene Therapy. AU - Paredes, Alejandro. AU - AL Qtaish Hasan, Nuseibah AU - Sainz-Ramos, Myriam AU - Lopez-Mendez, Tania AU - Villate-Beitia, Ilia. AU - Gallego, Idoia AU - Puras, Gustavo AU - Pedraz, Jose Luis. PY - 2020/7. Y1 - 2020/7. N2 - Introduction: Gene therapies are rapidly becoming a critical component of the therapeutic armamentaria for a variety of inherited and acquired human diseases (1). Nevertheless, the development of safer and more efficient vectors for gene delivery remains an area of great potential for improvement. Nanodiamonds (ND) are a highly biocompatible material with unique physicochemical features that make them an attractive platform for the development of novel non-viral vectors (2). In this work, we describe for the first time the combination of a cationic lipid (DOTMA) and ND to gene delivery purposes.Methods: ND-DOTMA vectors were obtained by an o/w emulsification method. The oil phase, ...
TY - JOUR. T1 - Monocyclic β-lactams loaded on hydroxyapatite: new biomaterials with enhanced antibacterial activity against resistant strains.. AU - Giacomini, Daria. AU - Torricelli, Paola. AU - Gentilomi, G.. AU - Boanini, Elisa. AU - Gazzano, Massimo. AU - Bonvicini, F.. AU - Benetti, E. AU - Soldati, R. AU - Martelli, Giulia. AU - Rubini, K.. AU - Bigi, A.. PY - 2017/6/2. Y1 - 2017/6/2. N2 - The development of biomaterials able to act against a wide range of bacteria, including antibiotic resistant bacteria, is of great importance since bacterial colonization is one of the main causes of implant failure. In this work, we explored the possibility to functionalize hydroxyapatite (HA) nanocrystals with some monocyclic N-thio-substituted β-lactams. To this aim, a series of non-polar azetidinones have been synthesized and characterized. The amount of azetidinones loaded on HA could be properly controlled on changing the polarity of the loading solution and it can reach values up to 17 wt%. ...
A multi-density polymeric interbody spacer formed from biocompatible material for osteoconductivity includes multiple density regions of different porosity to provide both strength and osteoconductivity. An interface region is formed between the density regions to provide both direct adhesion and mechanical interlocking between the different density regions to increase the strength of the multi-density polymeric interbody spacer. A method for forming the multi-density polymeric interbody spacer includes curing a first density region to achieve a first target porosity. A second density region may then be molded to the first density region to achieve a second target porosity. A portion of the second density region partially flows into pores of the first density region, providing direct adhesion and mechanical interlocking between the first and second density regions.
Indigo Microfiber Applicator - Indigo microfiber takes on a new shape! The Indigo Microfiber Applicator is made of the same outstanding microfiber as the Indigo Edgeless Microfiber Polishing Cloth. This 70/30 microfiber is woven from threads ...
In recent years, the development and application of decellularized extracellular matrices (ECMs) for use as biomaterials have grown rapidly. These cell-derived matrices (CDMs) represent highly bioactive and biocompatible materials consisting of a complex assembly of biomolecules. Even though CDMs mimic the natural microenvironment of cells in vivo very closely, they still lack specifically addressable functional groups, which are often required to tailor a biomaterial functionality by bioconjugation. To overcome this limitation, metabolic glycoengineering has emerged as a powerful tool to equip CDMs with chemical groups such as azides. These small chemical handles are known for their ability to undergo bioorthogonal click reactions, which represent a desirable reaction type for bioconjugation. However, ECM insolubility makes its processing very challenging. In this contribution, we isolated both the unmodified ECM and azide-modified clickECM by osmotic lysis. In a first step, these matrices were ...
The hereditary hemophilias are the most common inherited severe bleeding disorders and are characterized by lifelong bleeding, both spontaneous, internal bleeding as well external bleeding due to injury, most commonly from surgical procedures. The current research grant proposes to develop a new biocompatible matrix employing nanotechnology that is hemostatic by incorporating a peptide that accelerates blood coagulation and will therefore stop bleeding. This peptide was discovered in my laboratory and reduces bleeding in animal models of hemorrhage. Therefore, attaching this peptide to „nanotechnology‟ based materials has great promise as a novel agent to reduce bleeding from external hemorrhagic injuries. The methodology will include utilizing standard biochemical techniques to characterize the material followed by the testing of the biocompatible material in animal models. The development of this product is especially relevant to the goals of the Canadian Hemophilia Society by discovering ...
Jorge Almodovar. Jorge Almodóvar earned his B.S. in Chemical Engineering from Iowa State University in 2007. He then enrolled in Colorado State University where he earned his Ph.D. in Chemical Engineering in 2011. At CSU he investigated the delivery and stability of growth factors using polysaccharide-based biomaterials. After CSU, he worked as a Post-Doctoral Fellow at the Grenoble Institute of Technology in Grenoble, France investigating the formation of gradients on polyelectrolyte multilayer films, funded by the Whitaker International Program. Currently he is an assistant professor in the Chemical Engineering Department at the University of Puerto Rico-Mayagüez. His research interests include extracellular matrix mimetic biomaterials, cell-material interactions, and growth factor delivery. His research focus is on the engineering of biomimetic materials-inspired by the native cell environment-for fundamental studies, therapeutics, and regenerative medicine.. ...
Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
Lawrence Stanton joined the Genome Institute of Singapore in 2002, where he serves as an Associate Director. He holds Adjunct Professorships at the Department of Biological Sciences, National University of Singapore, and School of Biological Sciences, Nanyang Technological University. His current research is focused on the molecular characterization of transcriptional regulatory networks in stem cells and disease-specific iPSC cells with the aim to direct the growth, differentiation, and reprogramming of these cells into therapeutically useful tissues and models of human diseases. Recently, the lab has been generating induced pluripotent stem cells (iPSC) from patients with neurological disorders. These patient-specific iPSC are then converted into various neural cell types, which provides us the opportunity to study diseased neural tissue in vitro. By generating micro-tissues of neural origin by bioengineering multiple cell types in 3-D on biocompatible materials his group is collaborating ...
0056]In some embodiments, tissue contacting members 102 are coupled with support member 104. Support member 104 may be made of any suitable biocompatible material, such as titanium, stainless steel, nickel titanium alloy (Nitinol) or the like. Support member 104 may be coupled with tissue contacting members 102 by any suitable means, such as but not limited to one or more adhesive substances, placement of a portion of support member 104 within a sleeve on tissue contacting members 102 or a combination of both. Like tissue contacting members 102, support member 104 may also be malleable or deformable to allow for insertion of ablation device 100 through a minimally invasive sheath 124 and/or for enhancing conformability of device 100 to a surface of heart 140. Support member 104 typically includes at least one support arm 106 or similar protrusion or multiple protrusions for removably coupling ablation device 100 with positioner 114 or one or more other positioning devices. Positioner 114, for ...
Heterostructures of wide bandgap semiconductors such as silicon carbide (SiC) or group-III nitrides are attracting increasing interest for applications in the field of chemical and biological sensing. These biocompatible materials are particularly promising due to the possibility of bandgap engineering using the different SiC polytypes or AlxGa1-xN alloys, which could allow to optimize the charge transfer between the semiconductor device and the functional layer. A basic requirement for semiconductor biosensors based on organic-semiconductor hybrid structures is the direct covalent attachment of functional organic layers to the semiconductor surface. In my Ph.D. thesis, I systematically study different routes to obtain such functional layers on SiC and AlGaN alloys, including the silanization and hydrosilylation processes ...
Free Online Courses In Biomedical Engineering Kelsey DeFrates is a rising senior at Rowan University in the biomedical engineering program and dreams of creating biocompatible materials to regenerate lost or damaged tissues or develop biosensors. She was awarded the. Stanfords Introduction to Robotics (CS223A) - and other popular computer science and engineering courses - are now available free online. The robotics. Interested residents must submit an application, which is available in print and.. Besides offering a community service for parents of toddlers, the preschool has been a training ground for Penn-Trafford students who are interested in becoming teachers. Students work with the toddlers in two semester-long classes and.. Helpful online courses and information for the physical education teacher who wants to continue to develop and grow! View all 79 Resources!. Bicycle Repair Online Classes A technical training school offering information and classes in bicycle mechanics, ...
Proplast: Polymer of polytetrafluoroethylene and carbon filaments; porous biocompatible material used in orofacial and middle ear reconstruction and as coating for metal implants.
Endodontic treatment can often be performed in one or two visits and involves the following steps:. The dentist examines and x-rays the tooth, then administers local anaesthetic. After the tooth is numb, the dentist places a small protective sheet called a dental dam over the area to isolate the tooth and keep it clean and free of saliva during the procedure.. The dentist makes an opening in the crown of the tooth. Very small instruments are used to clean the pulp from the pulp chamber and root canals and to shape the space for filling.. After the space is cleaned and shaped, the dentist fills the root canals with a biocompatible material, usually a rubber-like material called gutta-percha. The gutta-percha is placed with an adhesive cement to ensure complete sealing of the root canals. In most cases, a temporary filling is placed to close the opening. The temporary filling will be removed by your dentist before the tooth is restored.. After the final visit with your dentist, you must return ...
The sooner you get treated for tooth decay, the less likely youll lose your tooth. That could mean a simple filling-or you might need a root canal treatment if decay has reached the inner pulp.. Theres also another procedure for advanced decay called pulp capping. Its a bit more involved than filling a cavity but less so than a root canal. We can use it if decay has exposed or nearly exposed the pulp, but not yet infected it-otherwise, you may still need a root canal treatment to remove the diseased pulp tissue.. There are two types of pulp capping methods, direct and indirect. We use direct pulp capping if the pulp has been exposed by decay. After isolating the tooth to protect other teeth from contamination, we remove all of the decayed dentin up to the pulp. This may cause some bleeding, which well stop, and then clean and dry the tooth area.. Well then apply a protective biocompatible material directly over the pulp to promote healing and protect it from further infection. We then ...
Radiesse (Bioform Inc, USA) is a sterile, latex-free, non-pyrogenic, semi-solid, cohesive subdermal, injectable implant, whose principal component is synthetic calcium hydroxylapatite, a biocompatible material with over 20 years of use in medicine. T
Aging Analytical philosophy Anthropology ATP Biocompatible materials Biological age Cell types Death DNA External causes of death Extracellular Matrix (ECM) Gene Gene therapy Genetic engineering Genomics Growth factor Human rights Internal causes of death In vitro In vivo Life extension: soft, radical, maximum Metabolism Mitochondrion Moral person Nanotechnology Nucleic acids Omics Organ Partial immortalization Pimm…
Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...
Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...
Devices are disclosed for occluding defects in an annulus fibrosis to prevent conditions such as disc herniation and recurrent disc herniation. The preferred embodiments comprise an intradiscal component having a width greater than the width of the defect and a height less than the intervertebral spacing, and an extradiscal component physically coupled to the intradiscal component, the extradiscal component having a height greater than the intervertebral spacing. The components most preferably each comprise two outwardly extending arms, of equal or unequal length, oriented transversely with respect to one another. The arms of the extradiscal component are preferably of sufficient length to overlap at least a respective portion of the adjacent vertebrae. The invention further anticipates a body disposed between the intradiscal and extradiscal components to at least partially consume the defect. The body is composed of a natural or synthetic biocompatible material, such as a resilient or compressible
Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...
Next, a small opening is made in the surface of the affected tooth to give access to the pulp chamber and root canals. Tiny instruments are used, sometimes with the aid of a microscope, to remove the dead and dying pulp tissue from inside these narrow passageways. The chamber and empty canals are then cleaned, disinfected, and prepared to receive a filling of inert, biocompatible material. Finally, adhesive cement is used to seal the opening in the tooth, preventing future infection.. Following root canal treatment, your tooth may feel some sensitivity or tenderness for a few days. Over-the-counter pain relievers like ibuprofen are generally effective in relieving discomfort, but prescription medications may also be given if needed. During this period, it may help to avoid biting hard on the affected tooth. All of these symptoms, however, should be temporary.. To further protect the tooth and restore it to full function, its usually necessary to have a crown or other restoration placed on it. ...
An intraocular lens injector cartridge having a heat retention additive for helping the cartridge retain heat once the cartridge is warmed. Such additives can include an biocompatible material having high heat retention, for example, powdered gold.
0058]Although the casing 72, sleeve 74, initial fenestration burr 150 and fenestration polishing burrs 180 are described herein in terms of their presently preferred embodiments, it is to be understood that such disclosure is purely illustrative and is not to be interpreted as limiting. Thus, for example while the casing 72 is described as preferably being made from titanium, it may be fabricated from any biocompatible material which exhibits suitable characteristics that permit the prongs 92, 102 to engage the otic capsule bone 34 surrounding the fenestration 36 to lock the casing 72 therein. Similarly, while the casing 72 has been described as being assembled by welding the collar 76 to the sleeve 74, it may also be machined from a single piece of material. Correspondingly, more or fewer than three slits 82 may pierce the sleeve 74 in orientations other than equally spaced, and more or fewer than six (6) prongs 92, 102 may be formed on the sleeve 74 jutting outward therefrom in locations other ...
US Pharm. 2015;40(7):26.. Chapel Hill, NC-An invention by scientists at the University of North Carolina and North Carolina State might take the sting out of diabetes injections: a smart patch that detects increases in blood sugar levels and automatically secretes insulin doses into the bloodstream. No larger than a penny, the patch is covered with more than 100 small needles housing microscopic insulin and glucose-sensing enzyme storage units. In a study published in the Proceedings of the National Academy of Sciences, the patch lowered blood glucose in a mouse for 9 hours. Before the patch can be used in humans, clinical trials are needed. Said co-senior study author Zhen Gu, PhD, the patch works fast, is easy to use, and is made from nontoxic, biocompatible materials.. To comment on this article, contact [email protected] ...
Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of clinically suitable formulations of hybrid manganese dioxide (MnO2) nanoparticles (MDNP) using biocompatible materials to reoxygenate the TME by reacting with endogenous H2O2. MDNP containing hydrophilic terpolymer-protein-MnO2 or hydrophobic polymer-lipid-MnO2 provided different oxygen generation rates in the TME relevant to different clinical settings. In highly hypoxic murine or human xenograft breast tumor models, we found that administering either MDNP formulation before radiotherapy modulated tumor hypoxia and increased radiotherapy efficacy, acting to reduce tumor growth, VEGF expression, and vascular density. MDNP treatment also increased apoptosis and DNA double strand breaks, increasing median host survival 3- to 5-fold. Notably, in the murine model, approximately 40% of tumor-bearing mice were tumor-free ...
There is a strong need of new materials to address current limitations in wound healing and in the translational aspects of wound healing. Progress in this area is limited by the void of information at the molecular level addressing cell-material interactions, at the tissue level addressing the evolution of implantable scaffolds and at the organ level addressing the development of new intervention methods to enhance healing. This thrust aims to create novel materials and experimental techniques to overcome these challenges. By tackling the steps between materials development and implantation, it is generating design rules and predictive models to determine the viability of a material in enhancing wound healing. Thrust Members:. ...
Theres a lot of interest in soft materials, particularly biomaterials, explains Guenther of the materials that help create functional tissue cultures, but until now no one has demonstrated a simple and scalable one-step process to go from microns to centimeters. How exactly does a machine grow a large patch of living tissue?. Scientists manipulate biomaterials into the micro-device through several channels. The biomaterials are then mixed, causing a chemical reaction that forms a mosaic hydrogel-a sheet-like substance compatible with the growth of cells into living tissues, into which different types of cells can be seeded in very precise and controlled placements.. Unique to this new approach to tissue engineering, however, and unlike more typical methods for tissue engineering (for instance, scaffolding, the seeding of cells onto an artificial structure capable of supporting three-dimensional tissue formation) cells planted onto the mosaic hydrogel sheets are precisely incorporated into ...
Cadee JA, Brouwer LA, den OW, Hennink WE, and van Luyn MJ. (2001). A comparative biocompatibility study of microspheres based on crosslinked dextran or poly(lactic-co-glycolic)acid after subcutaneous injection in rats. J Biomed Mater Res 56: 600-9. PubMed. De Groot CJ, van Luyn MJ, Van Dijk-Wolthuis WN, Cadee JA, Plantinga JA, den OW, and Hennink WE. (2001). In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts. Biomaterials 22: 1197-203. PubMed. Geertsema AA, Schutte HK, Rakhorst G, van Luyn MJ, Mahieu HF, and Verkerke GJ. (2001). A novel tracheal tissue connector for fixation of laryngeal prostheses. Biomaterials 22: 1571-8. PubMed. Greijer AE, Verschuuren EA, Harmsen MC, Dekkers CA, Adriaanse HM, The TH, and Middeldorp JM. (2001). Direct quantification of human cytomegalovirus immediate-early and late mRNA levels in blood of lung transplant recipients by competitive nucleic acid sequence-based amplification. J Clin Microbiol 39: 251-9. ...
Dr. Guvendirens research focuses on designing novel polymeric biomaterials for tissue engineering applications and regenerative medicine. In particular, he is interested in spatiotemporal control of hydrogel properties, cell-biomaterial interactions, 3D bioprinting, biofabrication, surface pattering and photopolymerization. Applications of his research include regeneration of bone, cartilage and osteochondral interface as well as engineered in vitro disease models. Prior to joining NJIT, Dr. Guvendiren was an Assistant Research Professor at Rutgers University, at the New Jersey Center for Biomaterials. Dr. Guvendiren did a postdoc in Bioengineering and Materials Science and Engineering Departments at the University of Pennsylvania. He received his Ph.D. in Materials Science and Engineering at Northwestern University. ...
In 2010 I received my Bachelor in Biotechnology and in 2012 my Master degree in Biomedical Biotechnology from Universitat Politecnica de Valencia in Spain. Between 2012 and 2017 I pursued a PhD in Biomedical Biotechnology at the Universitat Politecnica de Valencia, obtained with European mention and honors. During my PhD my research activity was complemented by several internships, at the Centre for Cell Engineering at the University of Glasgow, 2012; a Marie-Curie-IAPP Program Secodment in Germany, 2013; and The Biomaterial Immuno-Engineering Lab at the University of Florida, 2014. I worked on investigating the role of fibronectin and growth factors on mediating cell-material interactions towards bone differentiation.. In 2017, I started as a Research Assistant in Professor Matthew Dalby reseach group where I have been working on growth factors and material-based strategies to engineer tissue repair and regeneration and with my own side project in 2019 on the discovery of metabolites involved ...
We report a highly biocompatible and practical protocol to create alginate microgels for bioactive encapsulation. Double-emulsion drops composed of dual cores enclosed by an ultrathin shell are prepared in a capillary microfluidic device, which exhibit selective coalescence between the cores. When the cores are laden with alginate precursors and divalent ions, respectively, coalescence leads to the formation of alginate microgels in the fused core of double-emulsion drops. The microgel can be rapidly released into a continuous water phase by rupturing the liquid shell. This method neither involves any toxic chemical cues for gelation nor long-term exposure to oil, thereby providing highly biocompatible encapsulation. ...
This report studies the global biomaterial market over the forecast period of 2012-2017. The global market for biomaterials is estimated at $44.0 billion in 2012 and is poised to grow at a CAGR of 15% from 2012 to 2017 to reach $88.4 billion by 2017.. The global biomaterial market is broadly segmented into two categories, by type and by application. The global biomaterial market, by type, is broadly categorized into metals, ceramics, polymers, and natural biomaterials. The biomaterial applications market is broadly segmented into orthopedic, cardiovascular, neurological, dental, tissue engineering, wound healing, plastic surgery, ophthalmology and other applications such as gastrointestinal, urinary, bariatric surgery, and drug delivery system. In 2012, the cardiovascular biomaterial segment contributed 34.5% to the global biomaterial market, followed by the orthopedic segment. Plastic surgery and wound healing applications are expected to witness the highest growth in the coming ...
In addition to a material being certified as biocompatible, it is important that biomaterials are engineered specifically to their target application within a medical device. This is especially important in terms of mechanical properties which govern the way that a given biomaterial behaves. One of the most relevant material parameters is the Youngs Modulus, E, which describes a materials elastic response to stresses. The Youngs Moduli of the tissue and the device that is being coupled to it must closely match for optimal compatibility between device and body, whether the device is implanted or mounted externally. Matching the elastic modulus makes it possible to limit movement and delamination at the biointerface between implant and tissue as well as avoiding stress concentration that can lead to mechanical failure. Other important properties are the tensile and compressive strengths which quantify the maximum stresses a material can withstand before breaking and may be used to set stress ...
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