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Exertional hypotension in thoracic spinal cord injury: case report.: Exertional hypotension is well described in quadraplegics, but there are few descriptions o

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Acrylamide, 2,5-hexanedione, Tri-o-tolyl phosphate and leptophos belong to three fundamentally different chemical classes but all four chemicals cause central-peripheral distal axonopathy. Some of these compounds have been shown to alter brain steady state levels of neurotransmitters or to inhibit the activities of adenosine triphosphatases which are involved in the uptake and storage of biogenic amines. Tests were performed to determine alterations in steady state levels of rat brain norepinephrine and dopamine in response to doses of the above chemicals and of the central nervous system toxin, methyl mercuric chloride sufficient to cause ataxia. Catecholamine synthesis rate constant estimations were performed. Specific activities of tyrosine in brains of control and treatment groups following intravenous injection of labelled tyrosine were compared to determine if passage of tyrosine across the blood-brain barrier were affected by treatments. Levels of the dopamine metabolite, dihydroxyphenylacetic

glutamate oxaloacelate transarninase [GOT] , glutamate. pyruvate transminase [GPT] - in to the culture medium. Cytotoxicity was also assessed by applying cell viability test, where dead cells aquired staining while living cells remained unstained. This study showed that methyldopa produced a damaging effect on cultured rat hepatocytecs and increasing the number of dead cells. The inclusion of albumin in the culture system provided a good protection to s against the damaging effect of methyldopa. Its probably advisable to provide a maximum availability of albumin ...

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ERS -Early repolarisation syndrome is known as a benign ECG finding for many decades .Now it is beginning to look dangerous as evidence is accumulating it may have a link with ventricular arrhythmias. ERS represents complex changes in ionic movements during cardiac repolarisation . (To be specific , it is due to a functional…

Methyldopa is an alpha 2 agonist. Methyldopa is useful in treating hypertension mostly in pregnant woman. The duration of action of methyldopa is 24 hours.

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The stress of foot shock in rats induces large decreases in the level of brain norepinephrine but does not greatly alter the concentration of serotonin or dopamine in brain. These decrements in norepinephrine are not limited to any region and occur uniformly throughout the brain. However, absolute levels of these amines are not a true indicator of their dynamic state. By various techniques it could be demonstrated that the stress of foot shock accelerates the metabolism of dopamine and serotonin to the same degree as norepinephrine; the only difference being that dopamine and serotonin are rapidly resynthesized, whereas norepinephrine in the brain cannot be regenerated at the same rate. Furthermore, the increased catabolism of brain norepinephrine with stress is blocked by monoamine oxidase inhibitors, whereas catechol-O-methyltransferase inhibitors do not impede accelerated degradation.. ...

d-Amphetamine is markedly more potent an inhibitor of catecholamine uptake by norepinephrine neurons in the brain than is 1-amphetamine, whereas the two isomers are equally active in inhibiting catecholamine uptake by the dopamine neurons of the corpus striatum. In behavioral studies, d-amphetamine is ten times as potent as 1-amphetamine in enhancing locomotor activity, while it is only twice as potent in eliciting a compulsive gnawing syndrome. This suggests that the locomotor stimulation induced by amphetamine involves central norepinephrine, while dopamine neurons play an important role in the induced compulsive gnawing behavior. Assessment of differential actions of d- and 1-amphetamine may be an efficient method to differentiate behaviors involving norepinephrine or dopamine in the brain. ...

After bilateral olfactory bulbectomy in rats a significant increase of norepinephrine (NE) level in the hypothalamus was found. However, no difference was observed between hypothalamic NE turnover of bulbectomized and sham operated animals. In the amygdaloid cortex the NE level was not affected by bulbectomy. In this area, however, the ... read more NE turnover appeared to be decreased after bulbectomy. The latter finding may be related to the deficits in passive avoidance behaviour as found in bulbectomized rats. show less ...

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The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP) ...

The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP) ...

repolarisation definition - the restoration of the usual electrical polarity of a nerve or muscle cell membrane after reversal of its polarity while a nerve impulse or muscle contraction ...

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Background: Assessing propensity to torsades de pointes (TdP) when exposed to QT-prolonging drug is challenging because baseline QT-prolongation has limited predictive value for identifying risk of TdP. The aim of this study was to determine whether computer-based repolarization morphology parameters could identify individuals who developed drug-induced TdP.. Method: Five-minute standard digital 12-lead ECGs were acquired at baseline and after a controlled sotalol challenge (2 mg/kg BW, i.v.) in 34 cardiac patients of whom 17 had a history of TdP (+TdPs) in the context of a QT prolonging drug and 17 had no history of TdP (-TdPs).Computerized ECG parameters including QT, TpTe (T peak to T end interval) and a morphological measure of the duration of the early part of the repolarization interval (ERD) were implemented. All parameters were corrected for the effect of heart rate (HR).. Results: There were 9 females among the + TdP patients and 12 females in the -TdP group (p = 0.8). The drugs ...

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Type 1 Diabetes is an autoimmune condition in which segments of the immune system cause the destruction of insulin producing cells in the pancreas, leaving individuals with an impaired ability to control blood glucose levels. Currently there is no cure for Type 1 Diabetes and the treatments involve lifelong insulin administration and careful monitoring of blood glucose levels. Long-term complications like cardiovascular disease, nerve damage, and retina damage, may result. Previous studies have shown that improvement in the control of blood glucose can reduce the risks from these long-term complications. Residual insulin production, typically within the first few years following diagnosis, helps to reduce an individuals need to supplement insulin by injection or pump. This effect helps in maintaining the bodys ability to regulate blood glucose levels and reducing the needs of external insulin.. Methyldopa, or Aldomet, has been approved by the Food and Drug Administration and is commonly used ...

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Abnormally rapid repolarisation of the infarcted muscle (accelerated opening of K+ channels). Current flow out of infarct (normal region negative relative to infarct). Occurs within seconds of infarction and last a few minutes ...

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If you have a fever and there seems to be no reason for it, check with your doctor. This is especially important during the first few weeks you take methyldopa, since fever may be a sign of a serious reaction to this medicine.. Before having any kind of surgery (including dental surgery) or emergency treatment, make sure the medical doctor or dentist in charge knows that you are taking this medicine.. Methyldopa may cause some people to become drowsy or less alert than they are normally. This is more likely to happen when you begin to take it or when you increase the amount of medicine you are taking. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.. Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help, but if the problem continues or gets worse, check with your doctor.. Methyldopa may cause dryness of the mouth. ...

In this paper, Freis evaluated the newly developed ganglion-blocking agent, methyldopa. He reported that it exhibited fewer side effects than a similar drug, guanethidine, yet it was not favored by patients since it required them to take a larger number of tablets at a greater frequency ...

TY - JOUR. T1 - Opiate antagonist facilitation of time-dependent memory processes. T2 - Dependence upon intact norepinephrine function. AU - Gallagher, Michela. AU - Rapp, Peter R.. AU - Fanelli, Richard J.. PY - 1985/11/18. Y1 - 1985/11/18. N2 - Post-training administration of opiate antagonists improves retention of recent learning in laboratory animals tested on a variety of tasks. We examined the possibility that this effect of opiate antagonist treatment might be due to release of brain norepinephrine (NE) function from opioid peptide inhibition. The behavioral testing procedure in these experiments consisted of one-trial passive avoidance conditioning. Rats received post-training treatments immediately after the training trial and retention was tested 24 h later. Lesions of the dorsal noradrenergic bundle (DNB) that were induced by 6-hydroxydopamine (6-OHDA) were found to prevent the memory enhancing effect of post-training naloxone administration. The memory enhancing effect of naloxone ...

It is important to recognize that a positive Coombs test, hemolytic anemia, and liver disorders may occur with methyldopa therapy.The rare occurrences of hemolytic anemia or liver disorders could lead to potentially fatal complications unless properly recognized and managed. Read this section carefully to understand these reactions. With prolonged methyldopa therapy, 10% to 20% of patients develop a positive direct Coombs test which usually occurs between 6 and 12 months of methyldopa therapy. Lowest incidence is at daily dosage of 1 g or less. This on rare occasions may be associated with hemolytic anemia, which could lead to potentially fatal complications. One cannot predict which patients with a positive direct Coombs test may develop hemolytic anemia.. Prior existence or development of a positive direct Coombs test is not in itself a contraindication to use of methyldopa. If a positive Coombs test develops during methyldopa therapy, the physician should determine whether hemolytic anemia ...

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