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LEMUS, DAVID et al. Antiangiogenic effect of betamethasone on the chick cam stimulated by TA3 tumor supernatant. Biol. Res. [online]. 2001, vol.34, n.3-4, pp.227-236. ISSN 0716-9760. http://dx.doi.org/10.4067/S0716-97602001000300010.. Tumor growth is the result of combined cell proliferation overwhelming cell death and neoangiogenesis. This report shows CAM angiogenesis promoted by TA3 tumor supernatant with or without low dosis of betamethasone (Minimal antiangiogenic concentration: ß-MAAC). Methylcellulose discs instilled with 10 µl of ß-MAAC (0.08 µg/ml),10 µl of tumor supernatant(TA3ts),5 µl ß-MAAC + 5 µl TA3ts, and 10 µl of PBS as control were implanted in host chick eggs. On day 12, the grafts were removed, photographed and fixed. Sections were stained in parallel, one and three with hematoxylin-eosin, and section two by the Tunel method. The number of vessels was evaluated in a microscopic field of the CAM (2250 µm2 ). The results show that ß-MAAC produced a significant ...
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Chang, Y-Lung.; Chang, S-Dyh.; Chao, A-Shine.; Hsieh, P.C.C.; Wang, C-Nin.; Wang, T-Hao., 2012: Placenta share discordance and umbilical artery Doppler change after antenatal betamethasone administration in monochorionic twins with selective intrauterine growth restriction: is there a link?
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POEM: Antenatal betamethasone beneficial to late preterm newborns Clinical Question: Does antenatal betamethasone given at 34 to 36 6/7 weeks of gestation improve outcomes for late preterm newborns? Bottom Line: Betamethasone administered to women at risk for late preterm birth reduces newborn respiratory complications, but with an increase in neonatal hypoglycemia. There was no evidence for…
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A simple RP HPLC method for quantification of betamethasone dipropionate (BDP) in gingival crevicular fluid (GCF) has been developed and validated. GCF represents a valuable matrix for therapeutic monitoring of drugs used in the treatment of periodontal disease. The proposed method involves single step extraction for sample preparation. The calibration curve for BDP was linear over the concentration range of 0.10-2.00 μg mL-1 (R2 = 0.9971). RSD values of intra- and inter-day precision ranged 2.2-4.5 and 1.6-5.7 %, while accuracy values were higher than 96.6 and 97.0 %, respectively. The described method can be successfully applied for determination of betamethasone concentrations in GCF obtained from patients with chronic periodontitis after local treatment with BDP cream 0.5 mg g-1. ...
PURPOSE: The aim of the study was to evaluate the effect of perioperatively systemically administered betamethasone on nerve recovery (within or outside a confined space) after induced nerve crush injury. MATERIALS AND METHODS: The sciatic nerve of 40 adult Wistar rats was crushed. In half of the animals, the injured nerve was entrapped in a silicone tube to simulate the environment of a closed space, and in the other half the nerve was left to heal. Half of the rats in each group were treated with subcutaneous betamethasone (2 mg/kg body weight/day) during the first 24 hours, starting preoperatively, whereas the other half, the control animals, were given the same amount of physiological saline. All animals underwent preoperative and postoperative walking track analysis (toe spread [TS] and intermediate toe spread [ITS]) twice weekly for 6 weeks. RESULTS: For nonconfined space groups, there was no significant difference between the 2 groups (P = .052 for ITS and P = .315 for TS) during the ...
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This study will compare efficacy and safety of once daily treatment of calcipotriol plus betamethasone dipropionate gel (LEO 80185) with tacalcitol ointment and LEO 80185 vehicle alone in subjects with psoriasis vulgaris. Subjects will be treated for up to 8 weeks followed by an observation period of up to 8 weeks to investigate the occurence and the time to relapse and occurence of rebound after discontinuation of the investigational products. Only subjects with controlled disease will be considered for this observation phase of the study. Controlled disease is defined as Clear or Almost Clear severity category based on Investigators global assessment (IGA ...
This study will compare efficacy and safety of once daily treatment of calcipotriol plus betamethasone dipropionate gel (LEO 80185) with tacalcitol ointment and LEO 80185 vehicle alone in subjects with psoriasis vulgaris. Subjects will be treated for up to 8 weeks followed by an observation period of up to 8 weeks to investigate the occurence and the time to relapse and occurence of rebound after discontinuation of the investigational products. Only subjects with controlled disease will be considered for this observation phase of the study. Controlled disease is defined as Clear or Almost Clear severity category based on Investigators global assessment (IGA ...
Betamethasone: Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin ...
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Calcipotriol/Betamethasone Dipropionate Cutaneous Foam Treatment for Psoriasis in Patients With Bsa 5-15% and PGA ≥3: Post-Hoc Analysis From Three Randomized Controlled Trials
Glucocorticoids appear to play an integral role in stimulating surfactant synthesis by activating the rate-regulatory enzyme for phosphatidylcholine synthesis, CTP:cholinephosphate cytidylyltransferase (CT). The activity of liver CT, in vitro, has been shown to be inhibited by the sphingomyelin hydrolysis product, sphingosine. In order to investigate the mechanisms by which glucocorticoids alter CT activity, in vivo, we administered betamethasone (1 mg/kg intraperitoneally) sequentially to adult male rats for 5 days. Betamethasone increased CT activity 2-fold relative to control in whole lung. The hormone also increased membrane-bound activity, but did not affect cytosolic enzyme activity. Betamethasone modestly increased CT mRNA as determined by the reverse-transcription PCR and Southern analysis of PCR products, but did not alter the levels of immunoreactive enzyme in lung membranes as demonstrated by Western blotting. The hormone did, however, produce a nearly 3-fold increase in ...
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View drug interactions between betamethasone and betamethasone topical. These medicines may also interact with certain foods or diseases.
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other minor skin conditions such as eczema.
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Betamethasone Dipropionate (bay-ta-METH-a-sone dye-PROE-pee-oh-nate) Treats skin pain, swelling, and itching. This medicine is a corticosteroid.
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Betamethasone dipropionate adalah steroid glucocorticoid dengan kebolehan anti-radang dan imunosupresif. Ia digunakan sebagai krim topikal, salap, losyen atau gel (Diprolene) untuk merawat gatal-gatal dan lain-lain keadaan kulit yang kecil seperti ekzema.
Also known as diprosone or diprolene, betamethasone dipropionate is a topical glucocorticoid used as an anti-inflammatory drug. It is used to treat skin conditions and allergies as it helps to suppress the immune responses. Learn more here.
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This part of the eMedTV site offers some basic information on calcipotriene/betamethasone dipropionate, a drug used to treat plaque psoriasis. This Web page takes a quick look at this medication and provides a link to more details.
FDA approval history for Enstilar (betamethasone dipropionate and calcipotriene) used to treat Plaque Psoriasis. Supplied by LEO Pharma
Indications for ENSTILAR (calcipotriene and betamethasone dipropionate aerosol, foam) refers to the medical reasons for why ENSTILAR is used and recommended as a treatment.
As this eMedTV page explains, it is not possible to know if you will have side effects with calcipotriene/betamethasone dipropionate before starting treatment, so you need to report anything unusual. A list of commonly reported problems is also included.
LEO Pharma Inc., a wholly owned U.S. subsidiary of LEO Pharma A/S, today announced a new Taclonex® (calcipotriene and betamethasone dipropionate) Topi
Learn about Betamethasone Dipropionate (Alphatrex, Maxivate and Diprosone), dosing, proper use and what to know before beginning treatment
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Preterm birth is associated with increased risk of type 2 diabetes (T2D) in adulthood; however, the underlying mechanisms are poorly understood. We therefore investigated the effect of preterm birth at ~0.9 of term after antenatal maternal betamethasone on insulin sensitivity, secretion and key determinants in adulthood, in a clinically relevant animal model. Glucose tolerance and insulin secretion (intravenous glucose tolerance test) and whole-body insulin sensitivity (hyperinsulinaemic euglycaemic clamp) were measured and tissue collected in young adult sheep (14 months old) after epostane-induced preterm (9M, 7F) or term delivery (11M, 6F). Glucose tolerance and disposition, insulin secretion, β-cell mass and insulin sensitivity did not differ between term and preterm sheep. Hepatic PRKAG2 expression was greater in preterm than in term males (P = 0.028), but did not differ between preterm and term females. In skeletal muscle, SLC2A4 (P = 0.019), PRKAA2 (P = 0.021) and PRKAG2 (P = 0.049) ...
Title: Understanding the effects of betamethasone on the extensor digitorum longus in fetal guinea pigs. Description: Glucocorticoids are steroid hormones that trigger cellular differentiation during animal development. Pregnant women at risk for preterm births are commonly administered synthetic glucocorticoids, such as betamethasone, in order to accelerate tissue maturation, and consequently increase the survival rate of premature newborns. A great deal of research shows the effects of prenatal steroids on lung tissue; however, the effects on breathing muscles remain unexplored. My research focused on studying the extensor digitorum longus muscle of fetal guinea pigs when exposed to betamethasone. In particular, I examined changes in protein expression of different myosin heavy chain isoforms by running SDS polyacrylamide gels.. ...
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushings syndrome, hyperglycemia, and glucosuria in some patients.. Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Use of more than one corticosteriod-containing product at the same time may increase total systemic glucocorticoid exposure. (See DOSAGE AND ADMINISTRATION.). Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.. Recovery of HPA axis function is generally prompt and ...
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