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Background Vestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether these effects persist after treatment cessation. Methods VIRTUOSO was a prospective, multinational, non-comparative, post-marketing observational programme investigating the effectiveness of betahistine (48 mg/day) and the course of vertigo after the discontinuation of treatment. Patients with vestibular vertigo who were prescribed 48 mg/day betahistine were enrolled in Russia and Ukraine. Treatment duration was up to 2 months, and patients were followed up for 2 months after discontinuation of betahistine. Efficacy endpoints included clinical response (assessed by change in vertigo severity), monthly attack frequency, and physician and patient grading of overall clinical response and improvement of vertigo-associated symptoms. Results Overall, 309
Second generation antipsychotic drugs (SGAs) cause substantial body weight gain/obesity and other metabolic side-effects such as dyslipidaemia. Their antagonistic affinity to the histaminergic H1 receptor (H1R) has been identified as one of the main contributors to weight gain/obesity side-effects. The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. It has been demonstrated that co-treatment with betahistine is effective in reducing weight gain, associated with olanzapine in drug-naïve patients with schizophrenia, as well as in the animal models of both drug-naïve rats and rats with chronic, repeated exposure to olanzapine. Betahistine co-treatment can reduce food intake and increase the effect of thermogenesis in brown adipose tissue by modulating hypothalamic H1R-NPY-AMPKα (NPY: neuropeptide Y; AMPKα: AMP-activated protein kinase α)
Although betahistine does not closely resemble histamine (see above), in the body it is a histamine agonist. There are 4 histamine receptors, namely H1-4. The rationale for its use is somewhat difficult to understand as H1 blocking antihistamines (such as meclizine, also an anticholinergic drug) are also used quite commonly to treat vertigo. Explanations commonly given are that the drug is a vasodilator, or that it acts on subreceptors of histamine. H1 and H2 are post-synaptic receptors and H3 is a pre-synaptic receptor. H4 is exitatory to the peripheral vestibular neurons (Wersinger et al, 2013). All four types of histamine receptors are found in the mouse ear as well (Takumida et al, 2016). Betahistine is a potent H3 receptor antagonist. (Lacour and Sterkers, 2001). Stimulation of the H3 receptor reduces histamine release, so antagonism of H3 increases histamine release. H3 receptors control the synthesis and release of histamine via a Gs protein (de Waele et al, 1995). Betahistines H4 action ...
Consumer information about the medication BETAHISTINE - ORAL , includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug BETAHISTINE - ORAL.
Betahistine 2HCl Biogened is a medicine available in a number of countries worldwide. A list of US medications equivalent to Betahistine 2HCl Biogened is available on the Drugs.com website.
Buy Betavert 48mg Tablet online (Betahistine) at cheap rate from India in USA, UK, China, Australia to cure Vertigo and Menieres disease. Betavert 48 mg is a manufactured by Sun Pharmaceutical Industries Ltd. and you can purchase it by using PayPal or Credit card.
By-Vertin information about active ingredients, pharmaceutical forms and doses by Helsinn, By-Vertin indications, usages and related health products lists
Question - Suffering from objective vertigo. Missed betahistine 16 mg tablets. What to do?. Ask a Doctor about diagnosis, treatment and medication for Vertigo, Ask a General & Family Physician
Auris Medical will develop betahistine dihydrochloride in a spray formulation for the intranasal treatment of Ménières disease and vestibular vertigo.
Question - I had been suffering with constant dizziness, head ache. There is no improvement with Betahistine Dihydorchloride tablets. Ask a Doctor about diagnosis, treatment and medication for Initially hearing loss, Ask a Neurologist
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Hello ronim, First, if youll allow me the usual medical disclaimer that none of us here at Google Answers are physicians, etc. How satisfying it would be if we could cure people but the only folks we cure are the terminally curious. I do hope the following information will make you a fully informed healthcare consumer though. The good news, thankfully, is that this condition isnt life-threatening, but it can one of the most frustrating and debilitating syndromes, both for the patients and the doctors treating them. Im sure it was a relief to get a negative MRI but youre probably asking now what? The ciproxin (or Cipro) your doctor prescribed is an antibiotic used to treat upper respiratory tract infections or possibly a sinus infection. Sometimes there may be a bacterial illness at work, so the first order of business is to nip that in the bud. The Stemetil is used to treat motion sickness and is also an anti-nausea drug. The betahistine hydrochloride is typically given to patients with ...
Histaminergic drugs, Histamine receptors agonists, , This medication is used to treat dizziness (vertigo) in those who have Menieres disease.
Has a clinically significant history or presence of any disease or unstable medical condition that might be affected by enrollment to this trial, as judged by the Investigator, including; Cardiovascular or cerebrovascular disease Diabetes mellitus (type 1 or 2); Malignant disease within 5 years of screening; Polycystic ovary disease; Hypertension (sitting blood pressure ,140/90 mmHg at screening or randomization), History of asthma symptoms in the past 5 years; History of peptic ulcers in the past 5 years; History of HIV, Hepatitis B or Hepatitis ...
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An H3 receptor antagonist is a classification of drugs used to block the action of histamine at the H3 receptor. Unlike the H1 and H2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1 receptors in the cerebral cortex. Consequently, unlike the H1 antagonist antihistamines which are sedating, H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimers disease. Examples of selective H3 antagonists include clobenpropit, ABT-239, ciproxifan, conessine, A-349,821,, betahistine, and pitolisant. The histamine H3 receptor (H3R) was discovered ...
[video]The Brain 013: Histamine boosts memory recall, Bottled water doubles Green Tea benefits, And More Nootropics News - posted in Brain Health: Histamine boosts memory recall, Bottled water doubles Green Tea benefits, And More Nootropics News https://youtu.be/td9X1_MavyQ 00:45 Betahistine, Histamine, for memory: Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories https://www.biologic...2021-3/fulltext https://medicalxpres......
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The primary conclusion of the trial will be based on the results of the primary outcome. If the result of the primary outcome is not statistically significant, the conclusion will be that there is no significant difference between the interventions. The results on all other types of outcomes will be reported for hypothesis-generating purposes. However, we will inspect the confidence interval (CI) to asses if the CI for the group difference contains values of importance, so that we cannot rule out interesting differences.. The primary analysis will include a modified intention-to-treat population, which is defined as all randomized patients, except patients who did not receive CPB-dependent cardiac surgery [9]. A secondary analysis will include the per-protocol population excluding patients with major protocol violations defined as: 1) patients who were randomized to an intervention but did not receive any intervention; and 2) patients who received an incorrect intervention. The dependent ...
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Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patients amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patients energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patients stimulation therapy parameters.
In this article we extend previous BMOM results by showing how information about a variance parameter and its relation to regression coefficients produces a rich class of postdata densities for regression parameters. Prediction and model selection techniques are also described. We also discuss the well-documented link between cross-entropy and the average log odds and then use this criterion in an experiment to compare results obtained from BMOM and Bayes approaches using data generated from known models.
In this fully revised and expanded edition of Smooth Tests of Goodness of Fit, the latest powerful techniques for assessing statistical and probabilistic models using this proven class of procedures are presented in a practical and easily accessible manner. Emphasis is placed on modern developments such as data-driven tests, diagnostic properties, and model selection techniques. Applicable to most statistical distributions, the methodology described in this book is optimal for deriving tests of fit for new distributions and complex probabilistic models, and is a standard against which new procedures should be compared. New features of the second edition include: Expansion of the methodology to cover virtually any statistical distribution, including exponential families. Discussion and application of data-driven smooth tests. Techniques for the selection of the best model for the data, with a guide to acceptable alternatives. Numerous new, revised, and expanded examples, generated using R code. ...
This paper looks at the patterns of causation between income, export, import, and investment growth for 25 developing countries. Our approach differs from previous efforts in a number of ways. First, we examine each country individually in order to allow for complete heterogeneity and properly account for the stochastic trending properties of the data. Second, we apply novel model selection techniques which are based on in-sample goodness-of-fit criteria and ex-ante predictive ability criteria to identify the best model for each country. Finally, we propose a rather novel device based on simple contingency tables which allows us to assess whether our models are capable of accurately predicting turning points in GDP growth. We find that countries with high trade exposure fare poorly in this dimension and posit that the GDP growth in such countries is best modeled using an index of global business cycle conditions, in addition to the above variables. Overall, we find that in around two thirds of ...
Based on the concept of Kolmogorov complexity, algorithmic statistics in a form of a computer program is proposed as an unified way of computing unknown probabilistic or non-probabilistic dynamic structures of high frequency time series data. Popular model selection techniques, such as AIC, BIC and MDL, all are shown not algorithmic statistics due to their computational infeasibility. We then address a fundamental question: Is there an algorithmic statistic that can extract more computable information of dynamic structure than maximum likelihood approach can? We address this question by comparing two algorithmic statistics: Viterbi and Hierarchical Factor Segmentation (HFS) algorithms, for decoding state-space vector under Hidden Markov Model and beyond. We discuss how to apply HFS algorithm to resolve parametric/non-parametric change-point problems without prior knowledge of number of changes as an example of non-probabilistic dynamic structure. We present applications of HFS algorithm on ...
A modified intent-to-treat (ITT) population was defined as all To determine a reasonable relative risk size for which to randomized participants who received at least one dose of study power this clinical efficacy endpoint, we estimated the annual exacerbation event rate using data on over 40,000 person-yearsrepresented in the CFF National Patient Registry during 1985- 3.11. Statistical analysis plan 2000 All patients born in 1985 or later and who werebetween the ages of 1 and 12 were classified into three mutually By design, the primary study endpoint for which the study exclusive groups at each calendar year: (i) patients with no is powered is the clinical efficacy endpoint, time to first positive Pa culture since birth; (ii) patients who had the first protocol-defined pulmonary exacerbation requiring intrave- positive culture during that year, and (iii) patients with at least nous antibiotics and/or hospitalization. The censored failure one positive culture in previous years. Based on ...
The statistical analysis plan for the randomised trial was finalised prior to unblinding and the nested diagnostic evaluation prior to analysis, performed by independent statisticians.. The primary analysis was by repeated measures analysis of covariance using a mixed model which took account of the within-subject variability, using scores at all three postrandomisation time points and adjusting for baseline anxiety and randomisation factors. The adjusted mean group differences between baseline and each time point with 95% CIs were calculated. Missing data in the STAI were imputed if one or two questions were unanswered in each form as per the test manual; with larger numbers of missing data, the questionnaire was excluded. To avoid bias, maximise the power of the study and allow analysis by intention-to-treat, the missing-indicator method was used.19 20 Estimates of sample size based on an expected mean STAI total of 47, SD of 12 and correlation between follow-up measurements of 0.2 showed that ...
Data from this study may be requested by qualified researchers six months after product approval in the US and/or Europe, or global development is discontinued, and 18 months after trial completion. Investigators may request access to anonymized IPD and redacted study documents which may include: raw datasets, analysis-ready datasets, study protocol, blank case report form, annotated case report form, statistical analysis plan, dataset specifications, and clinical study report. Prior to use of the data, proposals need to be approved by an independent review panel at www.clinicalstudydatarequest.com and a signed data sharing agreement will need to be executed. All documents are available in English only, for a pre-specified time, typically 12 months, on a password protected portal. This plan may change if a determination is made that the data cannot be adequately anonymized ...
BACKGROUND: Ménières disease is an incapacitating disease in which recurrent attacks of vertigo are accompanied by hearing loss, tinnitus and/or aural fullness, all of which are discontinuous and variable in intensity. A number of different therapies have been identified for patients with this disease, ranging from dietary measures (e.g. a low-salt diet) and medication (e.g. betahistine (Serc®), diuretics) to extensive surgery (e.g. endolymphatic sac surgery). The Meniett® low-pressure pulse generator (Medtronic ENT, 1999) is a device that is designed to generate a computer-controlled sequence of low-pressure (micro-pressure) pulses, which are thought to be transmitted to the vestibular system of the inner ear ...
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A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering of blood pressure (BP) and/or lipids. This paper summarises the baseline characteristics, statistical analysis plan and feasibility of a randomised control trial of blood pressure and lipid lowering in patients post-stroke with the primary objective of reducing cognitive impairment and dementia. The Prevention Of Decline in Cognition After Stroke Trial (PODCAST) was a multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial internal pilot trial running in secondary and primary care. Participants without dementia were enrolled 3-7 months post ischaemic stroke or spontaneous intracerebral haemorrhage, and randomised to intensive versus guideline BP lowering (target systolic BP |125 mmHg versus |140 mmHg); patients with ischaemic stroke
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The Penicillin for the Emergency Department Outpatient treatment of CELLulitis (PEDOCELL) trial: update to the study protocol and detailed statistical analysis plan (SAP).
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