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High-level prescribing trends for Other Lipid-Regulating Preps (BNF code 021200000) across all GP practices in NHS England for the last five years. You can see which CCGs prescribe most of this chemical relative to its class, or learn more about this site.. View all matching dm+d items.. ...

Human antioxidant-response element (hARE) containing two copies of the AP1/AP1-like elements arranged as inverse repeat is known to mediate basal and beta-naphthoflavone-induced transcription of the type 1 NAD(P)H:quinone oxidoreductase (NQO1) gene. Band-shift assays revealed that beta-naphthoflavon …

Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that offers antitumor activity against mammary carcinomas (4C6); nevertheless, its system of actions continues to be uncertain. of advancement, defenses, circadian tempo and tumor biology (7,9,10). The part of AhR in breasts tumor biology offers been thoroughly looked into, and remarkably raising proof shows that the best response of breasts tumor to AhR is definitely reliant upon estrogen receptor (Emergency room) position, ligand existence and cell type (11C13). Deregulation of Emergency room expression is buy TAPI-0 definitely important in the development of breasts tumor, and estrogen-mediated ER alpha dog (ER) activation promotes breasts tumor growth (14). Under particular conditions, agonist-activated AhR requests Emergency room protein ubiquitination and degradation, and upregulation of enzymes that metabolize estrogen, which inhibits estrogen-induced ER-positive ...

High-level prescribing trends for Aspirin Combined Preparations (BNF code 0407010W0) across all GP practices in NHS England for the last five years. You can see which CCGs prescribe most of this chemical relative to its class, or learn more about this site.. View all matching dm+d items.. ...

Buy BNF: Incoloy DS standards, CAS number: , from Bureau of Analysed Samples Ltd.; ideal for industrial analysis and testing. Available online at LGC Standards.

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We have analyzed the possible role of the aryl-hydrocarbon receptor (AHR) in the aging process of mice using a homozygous null mouse (Ahr-/-) line as a model. We studied 52 male and female Ahr-/- mice aged from 6-13 months. Forty-six percent died or were ill by 13 months of age. Ahr-/- mice developed age-related lesions in several organs, some of which were apparent after only 9 months of age. Cardiovascular alterations included cardiomyopathy (100%) with hypertrophy and focal fibrosis. Vascular hypertrophy and mild fibrosis were found in the portal areas of the liver (81%), and vascular hypertrophy and mineralization were common in the uterus (70%). Gastric hyperplasia that progressed with age into polyps was evident in the pylorus of 71% of the mice over 9 months of age. Ahr-/- mice had T-cell deficiency in their spleens but not in other lymphoid organs. The immune system deficiency described previously could be the origin for the rectal prolapse found in 48% of the null mice, associated

a Highest concentrations in test (30-50 mM) are 6-10 fold above current guideline recommendations for non-toxic chemicals. In addition, based on cytotoxicity data in other tests, significant cytotoxicity above 50% would have occurred b Phenobarbital and beta-Naphthoflavone Based on other findings of that study, the authors conclude that this effect is due to clastogenic effects rather than gene mutations. EMA has been tested in CHO cells in the presence and absence of metabolic activation (NTP, 2002). The test concentrations are up to the limit of cytotoxicity, but above the current guideline recommendation (5 mg/ml or 10 mM, whichever is the lowest). Apart from the high concentrations the study protocol is comparable to current guideline recommendations with acceptable restrictions. Although not necessary from a technical perspective, but in order to put the results into perspective in the category, two tests from the adjacent members of the category of lower alkyl (C1-C8) methacrylates, methyl ...

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There is an increased risk of bleeding when enoxaparin is administered to patients with low body weight. Refer to the BNF or the Shared Care Guideline for dosage adjustments required ...

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The present investigation was undertaken to more precisely establish where xenobiotics can be oxidatively metabolized and bioactivated within the lung. To accomplish this, antibodies raised against NADPH-cytochrome P-450 reductase (EC 1.6.2.4) and cytochromes P-450 BNF-B, PB-B, and PCN-E (the major forms of cytochrome P-450 induced by beta-naphthoflavone, phenobarbital, and pregnenolone-16 alpha-carbonitrile, respectively) that had been purified to apparent homogeneity from rat liver microsomes were used to determine the localizations and distributions of these enzymes immunohistochemically at the light microscopic level within lungs of untreated rats. Additionally, the intrapulmonary sites at which benzo(alpha)pyrene undergoes hydroxylation were identified in situ by means of fluorescence histochemistry. Immunohistochemical staining for NADPH-cytochrome P-450 reductase and cytochromes P-450 BNF-B, PB-B, and PCN-E was detected in bronchial epithelial cells, both ciliated and nonciliated (Clara) ...

We have developed an approach to classify toxicants based upon their influence on profiles of mRNA transcripts. Changes in liver gene expression were examined after exposure of mice to 24 model treatments that fall into five well-studied toxicological categories: peroxisome proliferators, aryl hydrocarbon receptor agonists, noncoplanar polychlorinated biphenyls, inflammatory agents, and hypoxia-inducing agents. Analysis of 1200 transcripts using both a correlation-based approach and a probabilistic approach resulted in a classification accuracy of between 50 and 70%. However, with the use of a forward parameter selection scheme, a diagnostic set of 12 transcripts was identified that provided an estimated 100% predictive accuracy based on leave-one-out cross-validation. Expansion of this approach to additional chemicals of regulatory concern could serve as an important screening step in a new era of toxicological testing.. ...

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in bone remodeling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts. While effects of AhR signaling in osteoblasts are well understood, the role and mech …

Amino acid analyses and peptide mapping were performed for the four main haemoglobins from the armoured catfish Pterygoplichthys pardalis; component I, which is functionally distinct from the others, is structurally unique, whereas components II, III and IV, functionally indistinguishable, are closely related in structure. Compositional difference indices are calculated for the four components and for the two major haemoglobins from the trout Salmo irideus, and the results are discussed in terms of structural relationships and evolutionary history of fish haemoglobins. ...

Synonyms: AH receptor-interacting protein, AIP, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, XAP-2, Immunophilin homolog ARA9, XAP2, ARA9, FKBP16, FKBP37, SMTPHN.. ...

Ceftriaxone has undergone substantial changes which are live in digital versions and will appear in print in BNF for Children 2016-2017 and BNF 72. These changes reflect the updated Summary of Product Characteristics (SPC) for Rocephin® and also advice and feedback from expert opinion and the BNF formulary committees. Indication and dose Indications and doses […]

POTASSIUM PERMANGANATE Prescribing Notes: Available as 0.1% solution, which should be diluted 1 in 10, and as Permitabs®, where 1 tablet dissolved in 4 litres of water provides a 0.01% solution. See BNF and product literature for further information.. BNF Link: http://www.medicinescomplete.com/mc/bnf/current/6289.htm. ...

Anita C. Rudy, Paula M. Knight, D. Craig Brater and Stephen D. Hall. Stereoselective metabolism of ibuprofen in humans: Administration of R-, S- and racemic ibuprofen JPET 259: 1133-1139, 1991.. The Editor and Publisher regret the errors which appear in two equations printed on page 1135. The corrected equations are: [SEE THE EQUATIONS IN SOURCE PDF].. ...

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Following reports of heart failure, caution is advised when prescribing itraconazole to patients at high risk of heart failure (BNF ...

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The cure can, often, be as bad as the problem. My adrenal glands have failed, to compensate for which I have to take hydrocortisone three times a day. There is not, Im told, and the BNF seems to bear this out, an enteric-coated version of hydrocortisone available (that would keep it from dissolving in my…

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TY - JOUR. T1 - Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a lacI mammary epithelial cell line. AU - Sun, Yuan Wan. AU - Guttenplan, Joseph B.. AU - Khmelnitsky, Michael. AU - Krzeminski, Jacek. AU - Boyiri, Telih. AU - Amin, Shantu. AU - El-Bayoumy, Karam. PY - 2009/12/21. Y1 - 2009/12/21. N2 - The environmental pollutant 6-nitrochrysene (6-NC) is a powerful mammary carcinogen and mutagen in rats. Our previous studies have shown that 6-NC is metabolized to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene (1,2-DHD-6-NC) in rats and in several in vitro systems, including human breast tissue, and the latter is the proximate carcinogenic form in the rat mammary gland. Because optically active enantiomers of numerous polynuclear aromatic hydrocarbon (PAH) metabolites including chrysene have different biological activities, ...

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

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The problem here is that if pharmacies receive prescriptions for 60g of the ointment, once its gone, they will be able to properly supply the 120g and be paid for it...but the clinical indication for this product is clear - it shouldnt be used in a casual manner. Indeed the BNF states apply once a day to a maximum of 30% of the body surface for 4 weeks (max of 15g daily); If necessary treatment may be continued beyond the 4 weeks or repeated on the advice of a specialist ...

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